Georgian medical news最新文献

{"title":"PILOT STUDY ON THE CARDIOVASCULAR MORBIDITY IN OLDER PEOPLE IN THE REGION OF BURGAS IN BULGARIA.","authors":"D Gospodinov, S Pishev, B Parashkevova, N Gerasimov, G Petrova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiovascular morbidity is a leading cause of complaints in the older population.</p><p><strong>Objectives: </strong>The goal of this study is to present the results of a basic assessment of present cardiovascular diseases (CVD) in older people in the region of Burgas in Bulgaria.</p><p><strong>Methods: </strong>A six-month cross-sectional study was conducted in the municipality of Burgas. People aged 65 and older were interviewed at pensioners' clubs by a team of 4 physicians including cardiologists, and a pulmonologist. Clinical parameters were also measured.</p><p><strong>Results: </strong>A total 647 people participated in the study with a prevalent female cohort (84%). The average age was approximately 73 years. 426 (66%) of the people reported diagnosed diseases from 1 to 5 (1.7 on average per person). Blood pressure was elevated than the normal values of 140/90 mmHg with higher levels observed in the male group. All participants had glucose levels higher than the physiological norm of 5.6mmol/l. Total cholesterol in the male cohort was below the recommended values of 5.2mmol/l, while in the female cohort levels were higher (5.59mmol/l). HDL and LDL were found to be close to the values recommended for people without CVDs, and 85% reported hypertension.</p><p><strong>Conclusions: </strong>Hypertension is the most prevalent cardiovascular condition among the older population in Burgas. Almost all older individuals have comorbidities.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"142-147"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROTECTIVE EFFECTS OF CURCUMA LONGA IN A ROTENONE-INDUCED RAT MODEL OF PARKINSON'S DISEASE: ELECTROPHYSIOLOGICAL AND BEHAVIORAL EVIDENCE.","authors":"L Manukyan, L Darbinyan, K Simonyan, V Sargsyan, L Hambardzumyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration leading to motor deficits, yet effective neuroprotective therapies remain limited. Curcuma longa (turmeric), a traditionally cultivated spice in Southeast Asia, exhibits potent antioxidant properties that may counteract neurodegenerative processes. This study investigated the neuroprotective potential of orally administered turmeric extract (1100 mg/kg) in a rotenone-induced rat model of PD. Rats received rotenone (2.5 mg/kg) for 21 days to induce PD-like pathology, followed by concurrent turmeric treatment. Neuroprotective outcomes were assessed using in vivo electrophysiology and the Cylinder test to evaluate motor function and forelimb use asymmetry. Turmeric extract administration significantly prevented rotenone-induced degenerative changes and motor impairments, indicating preservation of neuronal integrity and function. These findings suggest that turmeric extract mitigates rotenone-induced neurotoxicity, supporting its potential as a therapeutic agent for PD. Further studies are warranted to elucidate the underlying molecular mechanisms and optimize dosing strategies.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"178-184"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF PEDIATRIC INTERNS' COMMITMENT TO PNEUMOCOCCAL VACCINATION: A CROSS-SECTIONAL STUDY IN MEDICAL UNIVERSITIES OF ALMATY, KAZAKHSTAN.","authors":"D Saussanova, M Baymuratova, A Amirzhanova, K Uspanova, T Slyambayev, Z Tobylbayeva, A Izbassarova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>According to the World Health Organization, pneumococcal infection (PI) is one of the leading causes of morbidity and mortality among children under the age of five worldwide, particularly in developing countries.</p><p><strong>Objective: </strong>To assess the awareness, attitudes, and adherence of pediatric interns toward pneumococcal vaccination. The study also aimed to identify specific knowledge gaps regarding vaccine characteristics, immunization schedules, and factors contributing to antibiotic resistance, in order to justify the need for improvements in immunoprophylaxis education within medical universities.</p><p><strong>Materials and methods: </strong>A total population cross-sectional sociological study was conducted among 6th- and 7th-year pediatric faculty interns from two medical universities in Almaty, Kazakhstan (n=50).</p><p><strong>Results and discussion: </strong>The findings revealed that most interns do not feel fully prepared to independently conduct pneumococcal vaccination, despite a high level of awareness regarding its importance. These results highlight the urgent need to implement targeted educational programs aimed at deepening future pediatricians' knowledge in the prevention of pneumococcal infections.</p><p><strong>Conclusion: </strong>The data obtained suggest the necessity of strengthening educational curricula in medical universities, focusing on in-depth study of immunoprophylaxis, clinical microbiology, and antibiotic therapy.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF HYPERBARIC, HYPEROXIA, PRESSURE AND HYPOXIA ON CD38 AND CD157 EXPRESSION IN ISOLATED PERIPHERAL BLOOD MONOCYTES: IN VITRO STUDY.","authors":"Z Al-Abady, N Jabbar, S Hamzah, M Al-Delfi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Oxygen therapy, utilizing both normal and elevated pressures, is a standard treatment for a range of medical conditions. Given that administered oxygen impacts the entire body, including blood constituents, this research examines how different oxygen and pressure environments influence gene expression in human peripheral blood monocytes.</p><p><strong>Methods: </strong>The treatment of isolated PBM with hyperbaric oxygen (HBO), hyperoxia, elevated pressure and hypoxia were performed. In addition, the expression of different Monocytes surface epitopes (CD38 and CD157 expression) were examined by qPCR technique. Normoxic culture media served as a positive control.</p><p><strong>Results: </strong>The impact of 90-minute exposures to hyperbaric oxygen, hyperoxia, and hypoxia on CD38 and CD157 expression in monocytes was investigated. Compared to normoxic controls, both hyperbaric oxygenation and hyperoxia significantly decreased (p < 0.05) CD38 and CD157 expression. Notably, CD157 expression exhibited a greater reduction under hyperbaric oxygenation than CD38. Conversely, hypoxia induced a significant increase in CD38 expression, while simultaneously reducing CD157 expression relative to normoxia.</p><p><strong>Conclusions: </strong>Changes in oxygen levels and pressure, specifically through hyperbaric oxygen, hyperoxia, and hypoxia treatments, demonstrably alter monocyte behavior and the expression of surface epitopes. These alterations could play a significant role in conditions where monocytes are implicated. The data aligns with existing research highlighting the influence of oxygen tension on cellular proliferation and protein production. Consequently, these findings underscore the potential importance of controlled oxygen administration, whether normobaric or hyperbaric, in clinical settings.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"148-154"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPACT OF EPILEPTIC FOCUS LATERALIZATION ON THE STRUCTURE OF DEPRESSIVE SYMPTOMATOLOGY IN FOCAL EPILEPSY.","authors":"A Velilyaeva, T Turayev, A Djurabekova, M Umarova, F Khalimova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Focal epilepsy commonly involves affective disturbances that compromise treatment adherence and exacerbate seizure frequency.</p><p><strong>Aim: </strong>To assess the impact of epileptic-focus lateralization on the severity of depressive symptoms in patients with focal epilepsy.</p><p><strong>Materials and methods: </strong>Sixty patients (30 left-hemisphere, 30 right-hemisphere) were evaluated with the Hamilton Depression Rating Scale (HAM-D), State-Trait Anxiety Inventory (STAI), Patient Health Questionnaire-15 (PHQ-15), Emotional Reactivity Index (ERI), a depression-awareness scale, and speech productivity measures. Data were analyzed using the Shapiro-Wilk test for normality, Student's t-test, and Mann-Whitney U-test (p<0.05).</p><p><strong>Results: </strong>Left-hemispheric group: Predominance of apathy, anhedonia, and heightened self-reflection; mean HAM-D 7.5±1.2, with 76.6% meeting the threshold for clinically significant depression (HAM-D≥8). Right-hemispheric group: Predominance of anxiety (STAI 9.0±1.0), somatiform complaints (PHQ-15 7.0±1.5), and emotional lability (ERI 8.0±1.2); 83.3% exhibited high anxiety, and 71% significant somatization (PHQ-15≥10). Speech productivity was markedly reduced (2.0±1.1), with monotony and low spontaneity.</p><p><strong>Conclusions: </strong>Epileptic-focus lateralization shapes affective disturbance profiles and should guide personalized psychopharmacological and psychotherapeutic strategies in focal epilepsy.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NITROSAMINES IN METFORMIN AND HYDROCHLOROTHIAZIDE: \"HUMAN SAFE PHOTOCARCINOGENS\" WITHIN THE POLYPHARMACY AS GENERATOR FOR PHOTOTOXICITY/ PHOTOCARCINOGENICITY AND THE SUBSEQUENT DEVELOPMENT OF MULTIPLE KERATINOCYTE CARCINOMAS. DOUBLE HATCHET FLAP AS OPTIMAL AND NECESSARY DERMATOSURGICAL DECISION IN TWO NEW PATIENTS.","authors":"G Tchernev, V Broshtilova, I Lozev, S Kordeva, I Pidakev, V Ivanova, KG Jr Tchernev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The issues that have been identified to date as potentially pivotal in relation to skin cancer in general, but also keratinocytic cancer in particular, mainly concern the permanent potentiation of concepts such as phototoxicity and hence its subsequent photocarcinogenicity over time. Studies by scientific teams dating back more than 50 years have defined the phototoxicity of nitrosamines as a rather non-specific property, regardless of whether the last mentioned have a carcinogenic effect or not. Recently or in 11/ 2024, hydrochlorothiazide was officially declared by the IARC/ International agency on cancer research as carcinogenic to humans due to its phototoxicity. Similar to sartans, metformin, beta blockers and calcium antagonists, hydrochlorothiazide are also associated with contamination from nitrosamines and all of them are scientifically and pathogenetically linked to phototoxicity and carcinogenicity in humans. The photocarcinogenic risk of those drugs in humans based on availability of nitrosamines in drugs seems to remain in all likelihood uncalculated by the regulators' tests, which are tailored to assess the purely carcinogenic risk, which in practice is also inaccurately calculated for a number of points. The cumulative phototoxicity and subsequent photocarcinogenicity in humans differ from pure carcinogenicity in bacteria and rodents. According to a number of international clinical observational studies, concomitant use of more than 1 antihypertensive drug is also associated with a significantly higher risk of developing skin cancer, and in patients with diabetes mellitus this risk is further increased. Polymedication of potentially contaminated drug production is logically associated pathogenetically with the intake of a larger amount of photocarcinogens and/or mutagens in parallel. The present article highlights and is indicative of the following facts: nitroso (photo)carcinogenesis is an undeniable fact that is integral to photocarcinogenesis and skin cancer pathogenesis. Nitrosogenesis of skin cancer is mediated and regulated most likely by the nitrosamine content of drugs. Drug-mediated Photo nitroso genesis/ Carcinogenesis of skin cancer accounts for the occurrence and progression of a significantly greater number of tumors compared to pure Photocarcinogenesis. Permanent intake of potentially contaminated polymedication leads to clinical manifestation of multiple skin tumors. We present two cases of patients who developed scalp tumors treated successfully with double hatchet flap. One of them developed a scalp tumor but also an additional auricular tumor in the context of a potential nitrosamine-contaminated polydrug regimen including 1) metformin, 2) bisoprolol, 3) amlodipine/valsartan/hydrochlorothiazide. The double hatchet flap technique and the role of drug-induced Nitroso Carcinogenesis/Photo Nitroso Carcinogenesis/Oncopharmacogenesis due to the permanent intake of phototoxic, genotoxic substances (within drugs), a","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"80-89"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NON-INVASIVE ESTHETIC TREATMENT OF INITIAL CARIES WITH RESIN INFILTRATION IN A PATIENT WITH AUTISM SPECTRUM DISORDER.","authors":"Z Yerkibayeva, G Yermukhanova, K Saduakassova, K Rakhimov, Z Abu, Y Menchisheva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report presents the case of an 11-year-old male patient diagnosed with Autism Spectrum Disorder (ASD), who was treated for mild dental fluorosis using the ICON® resin infiltration technique. The child's parents expressed concern about the esthetic appearance of the teeth, which was affecting his self-confidence in social situations. Clinical examination revealed carious lesions of the enamel on the central incisors corresponding to code 3 of the CAST system (distinct changes in enamel color due to demineralization, indicating a more advanced initial stage of caries). Vital staining was performed for diagnostic purposes and to assess the condition of the enamel, revealing significant demineralized areas. Additionally, light-induced fluorescence was used to confirm structural changes in the enamel. As part of the treatment protocol, remineralizing therapy was also administered using R.O.C.S. gel to enhance enamel structure. Considering the cooperative behavior of the patient and his mild sensory sensitivity, a non-invasive resin infiltration technique (ICON®) was selected. The procedure was carried out on the upper central incisors using a custom-designed device developed by our team for isolating the anterior tooth group, which served as an alternative to the conventional rubber dam. The infiltration protocol was followed step-by-step in accordance with the manufacturer's instructions. Immediately after the procedure, vital staining and light fluorescence methods revealed a marked improvement in tooth aesthetics, with white spots appearing less prominent and the enamel displaying a more uniform color. Resin infiltration provided good material integration with the enamel, significantly improving the appearance of the teeth. At the three-month follow-up, repeat examination using light-induced fluorescence and vital staining demonstrated stable results: the enamel remained uniform, the white spots had almost disappeared, and enamel color was preserved. The resin infiltrate exhibited durability with no signs of degradation or discoloration. The patient reported improved esthetic self-perception, which contributed to enhanced self-confidence. The treatment was performed without sedation and was well tolerated by the patient, resulting in satisfaction for both the child and his parents. Minimally invasive resin infiltration demonstrated high efficacy and esthetic benefit in the management of early caries on the central incisors in children with ASD, ensuring clinical success and patient comfort.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"121-126"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETERMINATION OF ROOT CANAL MICROBIOTA IN CHRONIC APICAL PERIODONTITIS AND EVALUATION OF THE MICROBIOLOGICAL ACTIVITY SPECTRUM OF POLYHEXANIDE AGAINST THE IDENTIFIED MICROBIAL FLORA.","authors":"Z Khabadze, A Vasilyev, Yu Generalova, O Avraamova, A Kulikova, A Generalova, L Vashurina, V Slonova, N Dolzhikov, A Umarov, A Wehbe, E Klochkovich","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic apical periodontitis is characterized by the formation of a stable mixed microbial flora within the root canal system. To improve the effectiveness of endodontic treatment, it is necessary not only to identify the microbiological composition of infected canals but also to select an irrigant with proven activity against key pathogens.</p><p><strong>Materials and methods: </strong>Microbiological samples were obtained from 35 patients with chronic apical periodontitis. The identification of microbiota was performed using cultural methods, MALDI-TOF MS, and 16S rRNA sequencing. The antibacterial activity of various irrigants, including Lavasept solution at concentrations of 0.1% and 0.2% (polyhexanide-based) sodium hypochlorite 3% and 2% chlorhexidine bigluconate, was evaluated against the most frequently isolated strains of primary microflora.</p><p><strong>Results: </strong>The most frequently detected microorganisms in the samples were Streptococcus mutans (42.86%), Streptococcus sanguinis (28.57%), Actinomyces israelii (34.29%), and Porphyromonas gingivalis (31.43%). Upon one-hour exposure, Lavasept solutions at concentrations of 0.1% and 0.2% completely inhibited the growth of these microorganisms, demonstrating equivalent effectiveness to 2% chlorhexidine bigluconate and 3% sodium hypochlorite.</p><p><strong>Conclusions: </strong>Polyhexanide-based solutions exhibit pronounced bactericidal activity against the main pathogens of chronic apical periodontitis. The obtained data support the feasibility of using polyhexanide-based solutions as an antiseptic irrigant in endodontic practice.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESULTS OF COMPREHENSIVE TREATMENT OF PATIENTS WITH ORTHODONTIC PATHOLOGY AND PATHOLOGICAL TOOTH WEAR.","authors":"S Dramaretska, O Udod, O Roman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>To analyze the treatment outcomes in patients with orthodontic pathology and pathological tooth wear under different approaches to correcting the position of the occlusal plane.</p><p><strong>Materials and methods: </strong>65 individuals with orthodontic pathology, impaired incisal guidance in the form of absence of the C. Christensen phenomenon, counterclockwise inclination of the occlusal plane, and pathological tooth wear were examined. Patients in Group I received treatment using bracket systems and micro-implants to correct the position of the occlusal plane, while patients in Group II were treated with bracket systems only, without any intervention regarding the occlusal plane. The jaw relationship was assessed according to E. Angle's classification, the level of incisal overlap, the presence of the C. Christensen phenomenon, and lateral cephalometric data were compared to evaluate the position of the occlusal plane relative to the Frankfurt horizontal (angle FH-OP) and the anterior cranial base (angle SN-OP). All patients underwent indirect tooth restorations using reinforced nano-hybrid composite material - 446 restorations in Group I and 489 restorations in Group II, the condition of which was evaluated using a number of criteria.</p><p><strong>Results: </strong>Before treatment, the FH-OP occlusal plane angle in Group I patients was 1.48±0.61, and the SN-OP angle was 8.92±0.78. In Group II patients, these values were 2.15±0.66 and 7.87±0.70, respectively - all values being below the normal range. After treatment, the FH-OP and SN-OP values in Group I approached the normal range, amounting to 8.55±0.61 and 13.82±0.54, respectively. Sagittal incisal guidance and the C. Christensen phenomenon were fully restored. Eight restorations (1.8%) exhibited marginal adaptation defects, 11 restorations (2.5%) had marginal discoloration, and 3 restorations (0.7%) had cracks; no chipping was observed. In Group II, FH-OP and SN-OP values improved to 2.41±0.67 and 8.12±0.48, respectively, but did not reach the normal range. Sagittal incisal guidance and the C. Christensen phenomenon were restored in only 6 patients (17.6%). Among the restorations, 43 (8.8%) exhibited marginal adaptation defects, 47 (9.6%) showed marginal discoloration, 57 (11.7%) had cracks, and 67 restorations (13.7%) had chipping.</p><p><strong>Conclusions: </strong>The results demonstrate the effectiveness of the applied treatment approaches for patients with orthodontic pathology and pathological tooth wear, which should be attributed to the normalization of the occlusal plane position, restoration of the C. Christensen phenomenon, the advantages of using orthodontic micro-implants, and the application of indirect tooth restorations.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOMATIC DYSFUNCTIONS IN THE MODELING OF OCCLUSAL AND EXTRAOCCLUSAL DISORDERS.","authors":"T Makichyan, E Gusakova, Z Khabadze, A Rylsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Due to the growing development of interdisciplinary collaboration between dentists and osteopaths, the study of somatic dysfunctions, as the primary target of osteopathic treatment, is becoming increasingly relevant. An increasing number of studies highlight the differing impacts of occlusal and extraocclusal disorders on the function of the temporomandibular joint and mandibular biomechanics. However, there is a lack of research analyzing the correlation between somatic dysfunctions and these disorders. Such analysis is essential for planning and evaluating the effectiveness of combined dental and osteopathic treatment. Therefore, this issue undoubtedly requires further investigation and analysis. This article continues previously initiated research, focusing on the impact of these disorders on the patterns of somatic dysfunction, as well as their potential clinical significance. The objective of the present study was to investigate the structure and severity of somatic dysfunctions associated with simulated occlusal and extraocclusal disturbances.</p><p><strong>Materials and methods: </strong>The study was conducted in three stages between November 2023 and January 2024. It included 20 healthy volunteers (10 men and 10 women) aged 20 to 40 years with no active somatic complaints. All participants underwent dental and osteopathic examinations, followed by simulation of occlusal and extraocclusal disorders. Occlusal disorders were simulated by placing temporary overlays on the 1st and 6th molars to increase vertical jaw separation. Extraocclusal disorders were modeled by placing a pad under the left ischial tuberosity to create pelvic asymmetry and induce an ascending extraocclusal disturbance.</p><p><strong>Results: </strong>The presence of occlusal and extraocclusal disorders significantly influenced the severity and manifestation of somatic dysfunctions: in volunteers, the somatic dysfunction scores increased significantly (p < 0.001). A clear association was also observed between the simulation of occlusal disorders and the development of global postural imbalances.</p><p><strong>Conclusion: </strong>The results indicate that both occlusal and extraocclusal disorders have a substantial impact on somatic dysfunctions, aggravating existing conditions and contributing to the development of new dysfunctions.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 361","pages":"90-93"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}