Georgian medical news最新文献

{"title":"GENETIC VARIANTS IN ANTIPSYCHOTIC METABOLISM: POLYMORPHISM PROFILES IN KAZAKH COHORT WITH PARANOID SCHIZOPHRENIA.","authors":"K Kovaleva, Z Kachiyeva, A Abetova, N Raspopova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Schizophrenia is a multifaceted psychiatric disorder characterized by hallucinations, delusions, cognitive impairments, and behavioral disturbances. Genetic factors significantly contribute to its pathogenesis, accounting for approximately 80% of the heritability. Globally, about 1% of the population is affected by schizophrenia, with 45,054 individuals in Kazakhstan receiving medical treatment for the condition, indicating a prevalence rate of 238,6 per 100,000 people. The rise in mental health disorders in Kazakhstan underscores the need for personalized treatment approaches to address these public health challenges. This study examines the influence of key polymorphisms - CYP2D6 (rs1135840), CYP3A5 (rs776746), COMT (rs4818, rs4680, rs9606186), CNR1 (rs1049353), HTR2A (rs6311, rs6313), and DRD2 (rs1799978, rs1800497) - on AP drug metabolism and therapeutic outcomes. The findings underscore the potential for genotype-guided AP dosage individualization in Kazakh individuals, laying a foundation for future research on optimizing AP therapy in this population.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF THE SECOND MESIOBUCCAL CANAL IN MAXILLARY FIRST MOLAR: A RETROSPECTIVE ANALYSIS.","authors":"Yu Fomenko, E Sukhostavets, N Hrechko, V Kuzina, N Mikhailenko, Yu Yaroslavska, S Skliar, Yu Mikulinska-Rudich, A Vlasov, V Smorodskyi, R Nazaryan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The first maxillary molar is one of the most difficult teeth for endodontical treatment; it presents the highest failure rates due to the impossibility of locating and treating the second mesiobuccal canal (MB2). The aim of our work was study of second mesiobuccal canal in maxillary first molar and compare obtained data with literature sources for increasing the efficiency of treatment.</p><p><strong>Materials and methods: </strong>The study involved 59 patients with exacerbation of chronic pulpitis or chronic periodontitis who were distributed according to age: 14-20 years, 21-30 years and 31-40 years. The average age was 31±2.98 years. Patients were investigated by operating dental microscope and computer tomograph with description of peculiarities of second mesiobuccal canal in maxillary first molar. A type of canal according to Vertucci was detected; general 76 teeth were described.</p><p><strong>Results: </strong>The second mesiobuccal canal was found in 65 (85.5%) of the 76 maxillary molars and in 29 (38.1%) of these MB2 canals it was accessible to the apex. We have detected that patients with chronic pulpitis or chronic periodontitis have significant different undetected MB2 canal in group 14-20 years (7.1%) and 31-40 years (19.4%), p<0.05. Such differences between groups could be explained by the development of pulpal calcification with long term inflammatory processes.</p><p><strong>Conclusion: </strong>First maxillary molar is possibly the most treated and least understood posterior tooth. Deep knowledge of anatomical and topological structure of the MB2 canal at the stage of diagnostics as well as during the course of endodontic treatment can help to decrease the percentage of unsuccessful treatment of the first molar. Clinicians need to be mindful of the possible presence of MB2 canal, which should motivate change in the routine practice of clinical endodontic treatment. Modifications in the endodontic access and detection techniques, as well as advancements in radiographic technique and magnification technology, aids in the location and treatment with the MB2 canal of the first maxillary molar.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHAGE-BACTERIA INTERACTIONS UNDER METAL STRESS: A STUDY OF THE NOVEL STENOTROPHOMONAS MALTOPHILIA PHAGE VB_STM18.","authors":"I Kusradze, O Rcheulishvili, N Karumidze, S Rigvava, A Rcheulishvili, R Goliadze, L Kamashidze, A Chipurupalli, N Metreveli, M Goderdzishvili","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stenotrophomonas maltophilia is a highly adaptable gram-negative bacteria, demonstrating resilience in metal-contaminated environment, which makes it a key subject for understanding microbial survival under heavy metal stress. This study investigates the effects of cadmium ions (Cd²⁺) on the growth dynamics, cadmium uptake, and bacteriophage vB_Stm18-host interactions, with implications for environmental microbiology and applied biotechnology. Growth analysis revealed that S. maltophilia tolerates Cd²⁺ at 0.01 g/L, although exposure prolonged the lag phase by 3 hours. Despite the initial growth inhibition, the bacterium adapted and achieved control-like growth levels by 18 hours. Bioaccumulation assays showed progressive cadmium uptake, reaching 1876 µg/g at 24 hours, highlighting its potential for bioremediation. The influence of Cd²⁺ on phage vB_Stm18's life cycle was assessed through adsorption efficiency and burst size measurements. Short-term exposure to Cd²⁺ caused minimal reductions in adsorption efficiency (97% vs. 98% in control) but significantly decreased the burst size to 17 particles per infected cell. Prolonged exposure exacerbated these effects, with adsorption efficiency decreasing to 58% and burst size dropping to 6 particles per infected cell, after 18 hours of pre-incubation. These findings suggest that cadmium alters bacterial surface structures, intracellular processes and disrupts phage replication and release. Therefore, this study sheds light on the molecular interplay between environmental pollutants and microbial systems providing valuable insights into microbial ecology in metal-contaminated habitats as well as informing strategies for optimizing phage therapy and bioremediation under heavy metal stress.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"117-122"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOCTURNAL ENURESIS SYMPTOMS AND RISK FACTORS AMONG CHILDREN AND ADOLESCENTS IN QASSIM REGION, SAUDI ARABIA.","authors":"E Alwashmi, A Alharbi, A Almadi, A Alhuraysi, M Almuhanna, B Alharbi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Nocturnal enuresis (NE), commonly referred to as nighttime bed wetting, is a common condition characterized by involuntary urination during sleep. This condition affects a significant number of children worldwide with a higher prevalence in boys than girls aged 6-12 years old. This study aims to evaluate the symptoms, assess the risk factors and address the response to different management types of this disorder among children and adolescents living in the Qassim region, Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional descriptive study was conducted among parents and caregivers of children and adolescents ranging from 5-18 years of age living in Qassim region, Saudi Arabia. Data collected by using an online survey, effectively disseminated through a multitude of online platforms, including popular websites and social media channels.</p><p><strong>Results: </strong>A total of 791 respondents participated in the study, with 173 (21.9%) completing the questionnaire, qualifying for inclusion due to having a child experiencing nocturnal enuresis. The participants had a mean age of 9.98 years. Significant gender differences were observed, with a higher frequency observed in boys (68.8%) compared to girls (31.2%). Participants reported positive family history and increased nighttime fluid intake associated factors. Comorbidities showed no significant associations, while lower parental educational status was identified as a contributing factor. The impact of nocturnal enuresis on families and individuals is substantial. Bladder muscle exercises were the most common treatment method, while pharmacological treatment was less frequently employed in our findings.</p><p><strong>Conclusion: </strong>We concluded that the impact and prevalence of nocturnal enuresis on children and adolescents in the region is significant. The higher incidence in boys, coupled with factors such as positive family history and lower parental educational status, emphasizes the multifaceted nature of this condition. The substantial effect on families underscores the importance of early intervention and support.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF VITAMIN D ON THE HISTOLOGICAL STRUCTURE OF LIVER AND LUNG IN MICE TREATED WITH AMPHOTERICIN B.","authors":"N Alkhafaji, M Ahmed, B Karem","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this work is to investigate the effects of L-AMB (Amphociene) on liver and lung tissues in adult mice, and the role of vitamin D3 in reducing its side effects. Amphotericin B (AMB), a polyene macrolide antibiotic, is used to treat serious fungal infections and leishmaniasis. It may cause increased serum aminotransferase and hyperbilirubinemia due to interference with hepatic cytochrome P450. This study aimed to determine whether vitamin D could improve liver and lung structural changes. We divided the twenty-four adult male mice into the following groups: The first group (G1) received normal saline orally for 28 days. In the second group (GII), Liposomal amphotericin B (L-AMB) (5 mg/kg body weight) was given for 28 days intravenously. In the group (GIII), vitamin D3 was given daily at a dose of 10000 IU. The fourth group received intravenously L-AMB at a dosage of 5 mg/kg body weight and vitamin D orally for 28 days. Liver sections of group II showed coagulative necrosis and vacuolar degeneration of hepatocytes, as well as Kupffer cell hyperplasia and inflammatory cell infiltration. Group IV showed a normal architecture of liver tissue with mild vacuolation and cloudy swelling of the hepatocytes. The lung sections of the treated group showed interstitial hemorrhages, hemosiderin pigmentation, inflammatory cell infiltration, and accumulation of serous exudate in alveoli. Group IV showed clear alveoli with a few red blood infiltrates. The study found that L-AMB causes structural changes in liver and lung tissue, and treatment with vitamin D3 reduced its deteriorating effects. Monitoring liver and lung function tests in patients with fungal infections who are taking L-AMB for a prolonged period is essential for preventing and treating liver and lung dysfunction.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"134-141"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MULTIPLE MUSHROOM-LIKE GROWING CYLINDROMAS OF THE SCALP (TURBAN TUMOR) IN A PATIENT WITH BROOKE-SPIEGLER SYNDROME: UNIQUE MANIFESTATION IN A BULGARIAN PATIENT.","authors":"G Tchernev, V Broshtilova, S Kordeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cutaneous cylindromas are rare, slow-growing adnexal tumors commonly found on the capillitium or face. When located on the capillitium, they can cluster together, forming a headgear-like structure that gives the characteristic \"turban\" appearance. Brooke-Spiegler syndrome, an autosomal dominant condition, is typically benign, though malignant transformation can occur. We present a 61-year-old male with a 30-year history of mushroom-like formations, clinically and histologically confirmed as cylindromas, affecting approximately half of the hairy part of the capillitium. In addition, an erythematous-livid plaque with ulceration and crusting was observed on both left and right lower legs. The patient was suspected of having a sporadic, non-inherited form of Brooke-Spiegler syndrome. Surgical excision of the mushroom-like lesions was recommended. In cases of non-inherited forms of Brooke-Spiegler syndrome, early detection and preventative measures are critical. A brief discussion focusing on the management of the condition is provided, emphasizing whether true sporadic cases of Brooke-Spiegler syndrome exist or if they represent another clinically \"silent\" form of the condition.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEEP LEARNING-BASED FRAMEWORK TO DETERMINE THE DEGREE OF COVID-19 INFECTIONS FROM CHEST X-RAY.","authors":"S Kummari, A Zope, P Juyal, P Sharma, S Das, S Varghese","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The corona virus disease-19 (COVID-19) epidemic, the whole globe is suffering from a medical condition catastrophe that is unprecedented in scale. As the coronavirus spreads, scientists are worried about offering or helping in the supply of remedies to preserve lives and end the epidemic. Artificial intelligence (AI), for example, has occurred altered to deal with the difficulties raised by pandemics. We provide an in-depth learning approach for locating and extracting attributes of COVID-19 from Chest X-rays. Hierarchical multilevel ResNet50 (HMResNet50) was adjusted to better COVID-19 data, which was collected to build this dataset with images of a typical chest X-ray from numerous public sources. We employed information enhancement methods such as randomized rotations with a ten-ten-degree slant, random noise, and horizontal flips to generate numerous images of chest X-ray. Outcome of the research is encouraging: the suggested models correctly identified COVID-19 chest X-rays or standard with an accuracy of 99.10 % for Resnet50 and 97.20 % for hierarchal Multilevel Resnet50. The findings suggest that the proposed is effective, with high performance and simple COVID-19 recognition methods.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"184-187"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTIVENESS OF COMBINED SURGICAL AND HORMONAL THERAPY IN TREATMENT OF ENDOMETRIOMAS.","authors":"E Chikhashvili, J Kristesashvili, M Urjumelashvili","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Endometrial cyst, or endometrioma, is a specific form of endometriosis that often reveals with severe symptoms and requires ongoing treatment. High rate of recurrence after surgical intervention presents a significant challenge in the management of this disease.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim of the study: &lt;/strong&gt;Aim of the study was to determine the effectiveness of combined therapy (surgical and hormonal) of endometrioma in terms of development of recurrences, the rate of pregnancy and change in pain intensity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;Study group consisted of 264 patients with endometrioma who underwent laparoscopic intervention with enucleation of endometrial cyst. The study group was divided into: Group I - patients who were treated with dienogest for 6 months continuously (n-58); Group II - patients treated with combined contraceptives (COC) for 6 months cyclically (n-62); Group III - patients treated with dydrogesterone for 6 months, cyclically (n-45); Group IV - control group, patients who did not undergo postoperative hormone treatment (n-99).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;At 5-year post-operative follow-up, the pregnancy rate was significantly higher in Gr.I (72.4% (n-21), P&lt;0.01) compared to control (34.8% (n-8)) and Gr.III (47.2% (n-17), P&lt;0.05). No significant difference in terms of pregnancy occurrence was found between Gr.III and the control group (P&gt;0.05). Assessment of pregnancy rate in Gr. II was not available as none in this group desired pregnancy. In Gr. I and Gr. III recurrence of endometrial cyst did not develop in any case, in Gr. II endometrioma recurrence was observed at 1.6%, which is significantly lower compared to control group (18.2%, P&lt;0.01). No significant difference between the groups of hormone therapy was detected (P&gt;0.05). After the hormone therapy, severe pain was not observed in any of the patients. Pain transformed from severe to moderate in Gr.I in 59.4% , in Gr. II - in 44.5% , in Gr. III - in 76.2%, in the control group -in 93.7% of cases and no longer experienced pain in Gr.I - 40.6%, in Gr.II -in 55.5%, in Gr.III - in 23.8%, in the control group - in 6.3 % . Treatment with dienogest and COC after surgery was found to be significantly more effective compared to the results obtained with Dydrogesterone (P&lt;0.05) or surgical treatment alone (P&lt;0.05). In patients with moderate pain, pain of moderate intensity did not remain in any patient in Gr.I, in Gr.II it remained at 3.8%, in Gr.III- in 16% and in the control group - in 46.9% (n-39). All forms of hormone therapy were found to be significantly more effective compared to treatment with surgical intervention alone (P&lt;0.05). No significant difference was found between the methods of hormone therapy in terms of moderate pain intensity (P&gt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;After surgical treatment of endometrioma, in cases of using different hormonal medications (Dienogest, COC, Dydrogesterone), the rate of r","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMALL BUT MIGHTY: CHARACTERIZATION OF VB_SPY_7, A LYTIC PHAGE TARGETING STREPTOCOCCUS PYOGENES.","authors":"S Rigvava, I Kusradze, N Karumidze, M Chichashvili, I Tchgkonia, M Goderdzishvili","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The emergence of antibiotic-resistant pathogens necessitates alternative therapies for treating microbial infections, especially in the oral cavity and upper respiratory tract. Our team has developed Phage Pastilles, a controlled-release formulation containing bacteriophages that target common pathogens, including Streptococcus pyogenes, Streptococcus salivarius, Staphylococcus aureus, Enterococcus faecalis, and E. coli. These pastilles incorporate eucalyptus oil and serve as a reservoir for gradually releasing bacteriophages, enhancing local therapeutic impact. This study focuses on the characterization of a novel lytic bacteriophage, vB_SPY_7, specifically targeting S. pyogenes which was incorporated into phage pastilles. Phage vB_SPY_7, isolated from wastewater, underwent host range analysis, plaque assays, adsorption kinetics, growth curve studies, electron microscopy, and whole-genome sequencing. Genomic analysis revealed that vB_SPY_7 is a member of the unclassified Caudoviricetes, with a 35,679 bp genome and 46 predicted ORFs, including essential structural and metabolic genes. Sequence analysis and biological characterization have demonstrated that vB_SPY_7 is a viable candidate for therapeutic use, and it is highly active when combined in a sustained-release format like Phage Pastilles.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"206-210"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATION BETWEEN EJECTION FRACTION AND CORONARY SINUS BLOOD FLOW DURING OFF-PUMP CORONARY ARTERY BYPASS GRAFTING SURGERY.","authors":"Ch Ejibishvili, M Kiladze, I Begashvili, G Grigolia","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Many studies have shown that coronary artery bypass grafting (CABG) increases the survival rate of patients, but the effect of bypass grafting on cardiac function is still a matter of debate.</p><p><strong>Objective: </strong>The objective of our study was to determine: a. To what extent can the change in coronary sinus flow be used as an intraoperative criterion for the assessment of adequate revascularization. b. Whether the functional improvement of the revascularized myocardium occurs. c. The existence of a correlation between the change in coronary sinus flow and changes in myocardial function.</p><p><strong>Material and methods: </strong>Our study included 435 adult patients of both sexes, aged 55-85 years, ASA -III or less, who underwent coronary artery bypass grafting on a functioning heart. For this part of the study, 70 patients were selected, in whom ejection fraction (EF) and coronary sinus blood flow (CSBF) were determined before and after bypass grafting by transesophageal echocardiography (TEE).</p><p><strong>Results: </strong>CSBF flow in the CS increases in 74% of cases after bypass surgery, does not change in 9% of cases, and decreases in 17% of cases. Based on the results obtained, ΔFlow and ΔEF - this distribution is not reliable (Сhi2=2.76, p=0.599, NS) There is no reliable correlation between intraoperative CSBF and EF.</p><p><strong>Conclusions: </strong>In off-pump CABG-surgery, CSBF increases in most cases when assessed shortly after revascularization. In cases where an increase in EF was observed, CSBF did not increase in most cases and vice versa, meaning that CSBF and cardiac EF did not correlate in the immediate post-revascularization period.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 355","pages":"163-166"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}