Frontiers in Neurology最新文献

{"title":"Extracranial carotid plaque calcification and its association with risk factors for cerebrovascular events: insights from the ANTIQUE study.","authors":"David Pakizer, Dana Šalounová, David Školoudík","doi":"10.3389/fneur.2025.1532883","DOIUrl":"10.3389/fneur.2025.1532883","url":null,"abstract":"<p><strong>Introduction: </strong>Extracranial carotid calcification is a common marker of advanced atherosclerosis. However, its impact on stroke risk is not consistent across studies, and examining the type of calcification and the presence of systemic diseases might be helpful. We aimed to investigate extracranial carotid calcification and its association with risk factors for ischemic cerebrovascular diseases.</p><p><strong>Materials and methods: </strong>Among 1,863 consecutive patients in the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the Carotid Bifurcation Plaque Study (ANTIQUE), 132 symptomatic or asymptomatic patients (177 carotid plaques) with >30% carotid stenosis examined through computed tomography (CT) and magnetic resonance imaging (MRI) were included. Statistical data were assessed using the <i>χ</i> ²-test, Fisher's exact test, <i>t</i>-test, and Mann-Whitney test to investigate the calcification risk factors.</p><p><strong>Results: </strong>Compared to the absence of calcifications, spotty calcifications were associated with male sex [odds ratio (OR): 3.72, 95% confidence interval (CI): 1.06-13.05], while large calcifications were associated with older patients (OR: 1.60 per 5 years of age, 95% CI: 1.20-2.13). Large calcifications were also strongly associated with coronary heart disease (OR: 4.07, 95% CI: 1.15-14.44) and atrial fibrillation (<i>p</i> = 0.025). In comparison between only spotty and large calcifications, spotty calcifications were associated with male sex (OR: 3.72, 95% CI: 1.06-13.05), smoking (<i>p</i> = 0.020) in more significant quantities (<i>p</i> = 0.014), and lipid plaque (<i>p</i> < 0.001), while large calcifications with contralateral stenosis degree (<i>p</i> = 0.044). No significant relationship was found between cerebrovascular events and the type of calcification.</p><p><strong>Conclusion: </strong>Although the presence and type of extracranial carotid calcification were not related to ipsilateral ischemic events, large calcifications were strongly associated with coronary heart disease and atrial fibrillation.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, identifier NCT02360137.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1532883"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective dorsal rhizotomy long-term effects on functional motility in Jordanian children with spastic cerebral palsy.","authors":"Yazan E Al-Kharabsheh, Anas Said, Ismail A Ismaiel, Issam Khawaja, Marwan Altaher, Ali Bani-Ahmed, Carmen M Cirstea","doi":"10.3389/fneur.2025.1502451","DOIUrl":"10.3389/fneur.2025.1502451","url":null,"abstract":"<p><strong>Introduction: </strong>Spasticity management in children with cerebral palsy (CP) is a challenge for healthcare providers worldwide. In the US and Europe, treatment options include non-surgical and surgical (i.e., selective dorsal rhizotomy, SDR) procedures, with beneficial effects on functional motility. SDR was introduced in Jordan in 2019. We performed the first assessment of the long-term effects on motor function in Jordanian children with spastic CP (SCP) who underwent SDR.</p><p><strong>Methods: </strong>A retrospective cohort study of 43 patients (28 boys, 15 girls, mean ± SD age at surgery, 6.2 ± 2.5 years, 67.4% with diplegia, 30.2% quadriplegia, and 2.3% hemiplegia, 97.7% bilateral deficits) who received SDR (42 bilateral) was conducted between 01/01/2019 and 03/01/2023. Gross Motor Function Classification System (GMFCS) and Functional Mobility Scale (FMS) scores were compared before and 12 months after SDR. Sex, age and clinical scores at surgery, and post-SDR surgical treatment were included in the model (IBM SPSS Statistics 29.0).</p><p><strong>Results: </strong>Clinical scores improved 12 months after SDR: GMFCS decreased by at least one level (in 58.5% of patients), and FMS significantly increased (<i>p</i> < 0.001); GMFCS decreased in 77.7% of those with pre-SDR severe impairment vs. 43.5% in moderately to mildly impaired patients. An age sub-analysis demonstrated higher changes in GMFCS in younger children (GMFCS decreased in 46.9% of those aged <10 years old vs. none in those older than 10 years). These findings suggest that younger children (<10 years old) and more impaired (levels IV and V on GMFCS) are likely the best candidates for this procedure. Twelve-month functional improvement was similar in boys and girls (GMFCS decreased in 44.0% of boys vs. 37.5% of girls). Compared to pre-SDR management, all patients continued physiotherapy, less received Botox (by 97.7%), and more received adjunct orthopedic surgeries (32.6% vs. none) after SDR; out of those receiving post-SDR adjuvant surgeries, 50.0% improved GMFCS (compared to 64.0% of those without).</p><p><strong>Conclusion: </strong>Our data demonstrated SDR's beneficial long-term effects on functional mobility in SCP children, particularly those younger than 10 years and more severely impaired. These findings provide critical information that may aid in identifying \"the best\" therapeutic window and \"the best\" candidate for SDR in Jordan.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1502451"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional study on the association between neutrophil-percentage-to-albumin ratio (NPAR) and prevalence of stroke among US adults: NHANES 1999-2018.","authors":"Chenglin Ye, Yong Mo, Tiansheng Su, Guangxiang Huang, Jiachao Lu, Shuling Tang, Qianrong Huang, Qiuyun Li, Qian Jiang, Fangzhou Guo, Pinghua Wu, Guozhong Zhang, Jun Yan","doi":"10.3389/fneur.2025.1520298","DOIUrl":"10.3389/fneur.2025.1520298","url":null,"abstract":"<p><p>The neutrophil-to-albumin ratio (NPAR) is a relatively novel composite biomarker of inflammation, which has been used for prognostication in cardiovascular diseases and may also be associated with stroke. A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, including 48,734 individuals with complete NPAR and stroke data. The association between stroke prevalence and NPAR values was assessed through multivariate regression analysis. The relationship between these variables was further visualized using restricted cubic splines (RCS). Additionally, potential factors influencing this relationship were explored through subgroup analysis. The regression model revealed a significant association between NPAR and stroke prevalence, even after adjusting for other covariates [1.06 (1.04, 1.08)]. Stroke prevalence was 62% higher in the highest NPAR group compared to the lowest [1.62 (1.40, 1.89)]. The RCS analysis further confirmed this positive correlation. Subgroup analysis showed that this association was not significantly influenced by other factors. This study establishes a strong association between NPAR and stroke prevalence. However, further studies are needed to clarify the underlying mechanisms and establish a direct causal link.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1520298"},"PeriodicalIF":2.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases.","authors":"Ana Romero Garavito, Valery Díaz Martínez, Estherz Juárez Cortés, José Vicente Negrete Díaz, Liliana Marcela Montilla Rodríguez","doi":"10.3389/fneur.2024.1505879","DOIUrl":"10.3389/fneur.2024.1505879","url":null,"abstract":"<p><p>This review explores the impact of physical exercise on brain-derived neurotrophic factor (BDNF) and its relationship with neurodegenerative diseases. The key role of BDNF in maintaining brain health is highlighted, and recent studies are analyzed that indicate an increase in BDNF levels following physical activity, particularly in young adults. Additionally, the interaction between the BDNF Val66Met genetic polymorphism and exercise on cognitive function is examined. The review emphasizes the possibility of exercise as a complementary therapy for neurodegenerative diseases, although further research is required to fully understand its effects.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1505879"},"PeriodicalIF":2.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality-based vestibular rehabilitation therapy in patients with acute unilateral vestibulopathy: a randomized controlled trial.","authors":"Jae Woo Lee, Chul Young Yoon, Jae Ha Kim, Young Joon Seo, Tae Hoon Kong","doi":"10.3389/fneur.2025.1519470","DOIUrl":"10.3389/fneur.2025.1519470","url":null,"abstract":"<p><strong>Introduction: </strong>Conventional vestibular rehabilitation therapy (VRT) requires significant time and resources, especially for patients with low compliance, limiting its effectiveness and accurate assessment. Studies have shown VRT using virtual reality (VR) to be effective, with meta-analyses confirming its superiority over conventional methods. However, methodological variations in VR remain a limitation. This study aimed to assess the effects of VRT using head-mounted display (HMD) VR technology in patients with acute unilateral vestibulopathy (AUVP) and compare the outcomes with conventional VRT.</p><p><strong>Methods: </strong>We conducted a single-blinded randomized controlled trial with 60 AUVP patients randomly assigned to VR or control groups. The VR group received VRT via VR, while the control group underwent conventional VRT. Both groups followed individual home-based programs for 8 weeks and visited the clinic every 2 weeks. Subjective dizziness symptoms were evaluated using the visual analog scale (VAS), dizziness handicap inventory (DHI), and Activities-specific Balance Confidence (ABC) scale. Compliance with home-based programs was assessed on a 0-2-point scale based on responses in a booklet guide.</p><p><strong>Results: </strong>Seven patients were lost to follow-up, leaving 26 and 27 patients in the VR and control groups, respectively. The mean patient age was 56.91 ± 12.11 years; 22 men and 33 women were included. Two-way repeated measures analysis of variance showed significant improvement in both groups for DHI and ABC scores. However, changes in DHI, VAS, and compliance scores did not differ between groups. Improvement in the physical domain of the DHI and ABC scores was significantly faster in the VR group (<i>p</i> = 0.019 for DHI, <i>p</i> = 0.0020 for ABC).</p><p><strong>Discussion: </strong>VRT using VR technology showed comparable efficacy to conventional VRT in AUVP patients. The VR group demonstrated greater improvement in the physical domain of the DHI and ABC scales, indicating enhanced confidence in movement and reduced perception of physical handicap due to dizziness.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1519470"},"PeriodicalIF":2.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research hotspots and trends in the application of electroencephalography for assessment of disorders of consciousness: a bibliometric analysis.","authors":"Jiawen Chen, Yanhua Shi, Zhao Dong, Feng Xu, Mengyu Zhou, Jing Zhu, Jie Gao, Su Liu","doi":"10.3389/fneur.2024.1501947","DOIUrl":"10.3389/fneur.2024.1501947","url":null,"abstract":"<p><strong>Objective: </strong>Disorders of consciousness (DoC) result from severe traumatic brain injury and hypoxia or ischemia of brain tissues, leading to impaired perceptual abilities. Electroencephalography (EEG) is a non-invasive and widely applicable technology used for assessing DoC. We aimed to identify the research hotspots in this field through a systematic analysis.</p><p><strong>Methods: </strong>Relevant studies published from January 1, 2004 to December 31, 2023 were retrieved from the Web of Science Core Collection database. The data were analyzed and visualized using CiteSpace, VOSviewer, and SCImago Graphica.</p><p><strong>Results: </strong>In total, 1,639 relevant publications were retrieved. The country with the highest number of publications was the United States, the most productive institution was Harvard University, the journal with the highest output was <i>Clinical Neurophysiology</i>, and the journal with the highest total number of citations was <i>Neurology</i>. The author with the most publications was Steven Laureys and the most common keyword was \"vegetative state.\"</p><p><strong>Conclusion: </strong>The field is undergoing rapid development, characterized by a proliferation of advanced technologies and an increased emphasis on international collaboration. The document offers an impartial perspective on the advancements of the research study for the benefit of the researchers.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1501947"},"PeriodicalIF":2.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of SASP in ischemic stroke: a deep dive into cellular mechanisms.","authors":"Dong Xie, Yang Liu, Fang-Biao Xu, Jin-Sheng Zhang","doi":"10.3389/fneur.2024.1513357","DOIUrl":"10.3389/fneur.2024.1513357","url":null,"abstract":"<p><strong>Background: </strong>The escalating incidence of ischemic stroke (IS) exerts a heavy toll on global health. Aging, a prominent risk factor, implicates the senescence-associated secretory phenotype (SASP) in IS pathogenesis. We postulated that alterations in SASP-related factor expression during IS correlate with remodeling of intercellular interaction networks and disease advancement. The present study endeavored to preliminarily dissect the SASP-IS nexus via combined bulk and single-cell transcriptome analysis.</p><p><strong>Methods: </strong>Aggregated expression profiles from human peripheral blood bulk chips and MCAO mouse single-cell sequencing data, followed by SASP gene analysis. Executed protein interaction network and enrichment assays. Investigated immune infiltration in stroke patients, managed quality control and annotation of single-cell data, cherry-picked central cells based on SASP scores, unearthed essential genes via enrichment analysis, conducted pseudo-time and intercellular communication studies, and prognosticated drugs for hub genes. Finally, authenticated core gene expression in serum of MCAO and Sham rats using real-time fluorescent polymerase chain reaction (RT-qPCR).</p><p><strong>Results: </strong>Fourteen hub genes were discerned. Seven cell types were annotated in MCAO mouse peripheral blood single-cell data. Basophils exhibited the highest SASP scores, with Lcp1 upregulated and Ccl3 downregulated in basophils of the MCAO group. Enrichment analysis divulged a significant association of Ccl3 with the cell apoptosis pathway and Lcp1 with immune responses. The Ccl3 gene is pivotal in basophils and basophil-neutrophil crosstalk. Additionally, we forecasted nagrestipen's regulatory function on Ccl3. RT-qPCR demonstrated a marked elevation in Lcp1 mRNA and a pronounced reduction in Ccl3 in the MCAO group relative to the Sham group.</p><p><strong>Conclusion: </strong>The Ccl3 gene in basophils and its immune cell interaction is a linchpin in the IS immune microenvironment. Ccl3 and Lcp1 might potentially modulate IS progression by influencing SASP, proffering novel prospects for IS clinical diagnosis and treatment.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1513357"},"PeriodicalIF":2.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RT-ring: a small wearable device for tremulous Parkinson's disease diagnosis in primary care.","authors":"Jolanda Buonocore, Basilio Vescio, Marida De Maria, Marianna Crasà, Rita Nisticò, Pier P Arcuri, Giuseppe L Cascini, Anna Latorre, Aldo Quattrone, Andrea Quattrone","doi":"10.3389/fneur.2025.1534205","DOIUrl":"10.3389/fneur.2025.1534205","url":null,"abstract":"<p><strong>Introduction: </strong>Differential diagnosis of rest tremor (RT) disorders is challenging, often requiring 123I-ioflupane single-photon-emission-computed tomography (DaTscan), an expensive technique not available worldwide. In the current study, we investigated the performance of a new wearable mobile device termed \"RT-ring\" in predicting DaTscan result in patients presenting with RT based on rest tremor inertial features.</p><p><strong>Methods: </strong>Consecutive RT patients underwent RT-ring tremor analysis, surface electromyography (sEMG), and DaTscan. The RT-ring is a miniaturized mobile device that uses machine learning based on inertial tremor data to estimate the RT pattern. This electrophysiologic tremor feature has proven to accurately predict DaTscan result. The primary outcome was the RT-ring's performance in distinguishing patients with and without striatal dopaminergic deficit.</p><p><strong>Results: </strong>Sixty-seven RT patients were enrolled, including 42 patients with striatal dopaminergic deficit and 25 with normal DaTscan. The RT-ring showed 85.0% sensitivity, 90.9% specificity, and 87.9% balanced accuracy in predicting DaTscan result, and demonstrated 96.8% agreement with sEMG in RT pattern classification.</p><p><strong>Conclusion: </strong>The RT-ring is a promising, non-invasive, user-friendly, wearable mobile device for supporting the diagnosis of tremulous Parkinson's disease in primary care settings, especially in low-income countries with limited access to dopamine imaging.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1534205"},"PeriodicalIF":2.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis.","authors":"Zheng Li, Wen-Qi Xu, Jiao-Qi Wang, Jia-Hui Yang, Xiao-Hua Shi, Cheng-Bing Wang, Zhong-Xin Xu, Jin-Lan Jiang","doi":"10.3389/fneur.2025.1519818","DOIUrl":"10.3389/fneur.2025.1519818","url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis aimed to investigate the effect of statins on the prognosis of patients with intracerebral hemorrhage (ICH).</p><p><strong>Methods: </strong>We conducted a systematic search using the keywords \"statin\" and \"intracerebral hemorrhage\" across four electronic databases (PubMed, Cochrane Library, Web of Science, and Embase) from their inception to October 31, 2023, to identify studies comparing the effects of statins on the prognosis of patients with ICH. The primary outcome was total mortality after ICH. This meta-analysis was registered online (PROSPERO ID: CRD42023493063).</p><p><strong>Results: </strong>Our initial search identified 5,543 studies. After applying inclusion criteria, 30 studies with a total of 42,298 patients were included in the final analysis. Our meta-analysis showed that statins significantly reduced overall mortality in patients with ICH (OR: 0.61; 95% CI: 0.51-0.73; <i>I</i> ² = 87%; <i>p</i> < 0.01). Subgroup analyses further demonstrated lower mortality in ICH patients treated with statins compared to those not treated, including in the propensity score matching (PSM) group (OR: 0.59; 95% CI: 0.48-0.74; <i>I</i> ² = 90%; <i>p</i> < 0.01), the prospective cohort study (PCS) group (OR: 0.56; 95% CI: 0.40-0.77; <i>I</i> ² = 89%, <i>p</i> < 0.01), and the retrospective cohort study (RCS) group (OR: 0.64; 95% CI: 0.51-0.81; <i>I</i> ² = 87%, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Our meta-analysis of 30 studies suggests that statin use may be associated with improved mortality and functional outcomes in patients with intracerebral hemorrhage (ICH).</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/, CRD42023493063.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1519818"},"PeriodicalIF":2.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous push administration of anti-seizure medications.","authors":"Raniah Aljadeed, Brian W Gilbert, Tallib Karaze, Megan A Rech","doi":"10.3389/fneur.2024.1503025","DOIUrl":"10.3389/fneur.2024.1503025","url":null,"abstract":"<p><p>Intravenous push (IVP) administration of anti-seizure medications is becoming increasingly popular among emergency departments. IVP administration eliminates the need for compounding and preparation by the pharmacy department, as well as the need to gather infusion materials or set up a patient's tubing and pump, all of which translate to faster drug administration. This is important given the time-sensitive nature of status epilepticus treatment. This review will discuss several anti-seizure medications, including phenytoin, fosphenytoin, valproic acid, levetiracetam, brivaracetam and lacosamide, for which evidence supports the safe and efficacious use of IV push administration.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1503025"},"PeriodicalIF":2.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}