Frontiers in Neurology最新文献

{"title":"Gender differences in the use of an upper-extremity exoskeleton during physically and cognitively demanding tasks- a study protocol for a randomized experimental trial.","authors":"Bettina Wollesen, Julia Gräf, Lasse Hansen, Anna Gurevich, Shirley A Elprama, Andreas Argubi-Wollesen, Kevin De Pauw","doi":"10.3389/fneur.2024.1401937","DOIUrl":"10.3389/fneur.2024.1401937","url":null,"abstract":"<p><strong>Background: </strong>Upper limb exoskeletons are recommended to alleviate muscle fatigue, particularly in working conditions inducing musculoskeletal discomfort like overhead work. However, wearing an exoskeleton might introduce cognitive-motor interference, affecting performance. Understanding its neural impact and potential gender differences in design effects is crucial. Therefore, the aim of this study is to examine exoskeleton effects addressing cross-gender comparisons, and exploring the impact on cognitive and physical workload in real-world scenarios. The research questions address the impact of exoskeleton use on muscle synergies, upper body posture, cognitive resources, comfort/discomfort, acceptance and usability.</p><p><strong>Methods: </strong>The cross-sectional study integrates a multifactorial mixed-measure design. Participants are grouped by gender (female vs. male) and working condition (with vs. without exoskeleton). Motor performance and underlying neuronal correlates (fNIRS) will be analyzed. Based on an <i>a priori</i> sample size calculation, 80 participants (40 female/40 male) will be recruited. Working performance will be assessed by 1. Physical Performance Task (PILE task) and 2. Precision Task (following the Fitts paradigm), while body postures will be monitored with an Xsens motion capture system. Brain activation will be captured with an fNIRS system comprising 32 active optodes. Postural comfort/discomfort, acceptance, and usability will be reported via standardized questionnaires.</p><p><strong>Discussion: </strong>The study will gain insights into potential gender differences in exoskeleton use and will contribute to designing and optimizing the implementation of exoskeletons by considering muscle synergies, movement variability and cognitive resource allocation. Additionally, the study also highlights user discomfort, a crucial factor that could impede widespread adoption, particularly among females, in real-world scenarios.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1401937"},"PeriodicalIF":2.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of intraventricular hemorrhage risk in preterm infants using mathematically simulated cerebral blood flow.","authors":"Irina Sidorenko, Silke Brodkorb, Ursula Felderhoff-Müser, Esther Rieger-Fackeldey, Marcus Krüger, Nadia Feddahi, Andrey Kovtanyuk, Eva Lück, Renée Lampe","doi":"10.3389/fneur.2024.1465440","DOIUrl":"10.3389/fneur.2024.1465440","url":null,"abstract":"<p><p>Intraventricular hemorrhage (IVH)4 is one of the most threatening neurological complications associated with preterm birth which can lead to long-term sequela such as cerebral palsy. Early recognition of IVH risk may prevent its occurrence and/or reduce its severity. Using multivariate logistic regression analysis, risk factors significantly associated with IVH were identified and integrated into risk scales. A special aspect of this study was the inclusion of mathematically calculated cerebral blood flow (CBF) as an independent predictive variable in the risk score. Statistical analysis was based on clinical data from 254 preterm infants with gestational age between 23 and 30 weeks of pregnancy. Several risk scores were developed for different clinical situations. Their efficacy was tested using ROC analysis, and validation of the best scores was performed on an independent cohort of 63 preterm infants with equivalent gestational age. The inclusion of routinely measured clinical parameters significantly improved IVH prediction compared to models that included only obstetric parameters and medical diagnoses. In addition, risk assessment with numerically calculated CBF demonstrated higher predictive power than risk assessments based on standard clinical parameters alone. The best performance in the validation cohort (with AUC = 0.85 and TPR = 0.94 for severe IVH, AUC = 0.79 and TPR = 0.75 for all IVH grades and FPR = 0.48 for cases without IVH) was demonstrated by the risk score based on the MAP, pH, CRP, CBF and leukocytes count.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1465440"},"PeriodicalIF":2.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing dissemination, quality, and reliability of Chinese brain tumor-related short videos on TikTok and Bilibili: a cross-sectional study.","authors":"Ren Zhang, Zhiwei Zhang, Hui Jie, Yi Guo, Yi Liu, Yuan Yang, Chuan Li, Chenglin Guo","doi":"10.3389/fneur.2024.1404038","DOIUrl":"10.3389/fneur.2024.1404038","url":null,"abstract":"<p><strong>Background: </strong>As the Internet becomes an increasingly vital source of medical information, the quality and reliability of brain tumor-related short videos on platforms such as TikTok and Bilibili have not been adequately evaluated. Therefore, this study aims to assess these aspects and explore the factors influencing the dissemination of such videos.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted on the top 100 brain tumor-related short videos from TikTok and Bilibili. The videos were evaluated using the Global Quality Score and the DISCERN reliability instrument. An eXtreme Gradient Boosting algorithm was utilized to predict dissemination outcomes. The videos were also categorized by content type and uploader.</p><p><strong>Results: </strong>TikTok videos scored relatively higher on both the Global Quality Score (median 2, interquartile range [2, 3] on TikTok vs. median 2, interquartile range [1, 2] on Bilibili, <i>p</i> = 1.51E-04) and the DISCERN reliability instrument (median 15, interquartile range [13, 18.25] on TikTok vs. 13.5, interquartile range [11, 16] on Bilibili, <i>p</i> = 1.66E-04). Subgroup analysis revealed that videos uploaded by professional individuals and institutions had higher quality and reliability compared to those uploaded by non-professional entities. Videos focusing on disease knowledge exhibited the highest quality and reliability compared to other content types. The number of followers emerged as the most important variable in our dissemination prediction model.</p><p><strong>Conclusion: </strong>The overall quality and reliability of brain tumor-related short videos on TikTok and Bilibili were unsatisfactory and did not significantly influence video dissemination. Future research should expand the scope to better understand the factors driving the dissemination of medical-themed videos.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1404038"},"PeriodicalIF":2.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum calcium and in-hospital mortality in intensive care unit patients with cerebral infarction: a cohort study.","authors":"Kaiwu Meng, Xiaoyang Lei, Dian He","doi":"10.3389/fneur.2024.1428868","DOIUrl":"10.3389/fneur.2024.1428868","url":null,"abstract":"<p><strong>Background: </strong>The relationship between serum calcium levels and the prognosis of cerebral infarction remains controversial.</p><p><strong>Purpose: </strong>This study aims to investigate the correlation between serum calcium levels and in-hospital mortality in critically ill patients with ischemic stroke admitted to the intensive care unit (ICU).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using data from the MIMIC-IV database. Demographic and clinical data of all participants were collected including gender, age, hypertension, diabetes, myocardial infarction, heart failure, chronic obstructive pulmonary disease, hemoglobin, potassium, sodium, anion gap, platelets, white blood cells, glucose, creatinine, Glasgow coma score (GCS), IV-tPA administration (rt-PA), and mechanical thrombectomy (MT). The outcome measure was in-hospital death. Multivariable-adjusted logistic regression analysis, curve fitting, interaction analysis, and threshold effect analysis were employed to evaluate the relationship between serum calcium levels and in-hospital mortality among ICU patients with cerebral infarction.</p><p><strong>Results: </strong>A total of 2,680 critically ill patients with cerebral infarction were enrolled, with a mean serum calcium level of 8.6 ± 0.8 mg/dL. The overall in-hospital mortality rate was 19.5%, where Group 1 (serum calcium < 8.0 mg/dL) had a mortality rate of 27.7%, Group 2 (serum calcium 8-9 mg/dL) had a rate of 19.8%, and Group 3 (serum calcium ≥ 9 mg/dL) had a rate of 13.9%. There was a non-linear, S-shaped relationship between serum calcium levels and in-hospital mortality. Serum calcium levels within the range of 7.70-9.50 mg/dL were found to be independently associated with increased in-hospital mortality in ICU patients with cerebral infarction. No significant interactions were detected in subgroup analyses, and the results of sensitivity analyses remained stable.</p><p><strong>Conclusion: </strong>Serum calcium levels are independently associated with in-hospital mortality in critically ill patients with cerebral infarction in the ICU setting. Within the range of 7.70-9.50 mg/dL, lower serum calcium levels increase the risk of in-hospital death among these patients, emphasizing the importance of close monitoring by ICU physicians.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1428868"},"PeriodicalIF":2.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical differences between traumatic and NOS chronic subdural hematoma.","authors":"Yongxiang Yang, Xiansong Zhu, Tao Yang, Kexia Fan, Jingmin Cheng, Yuan Ma","doi":"10.3389/fneur.2024.1453629","DOIUrl":"10.3389/fneur.2024.1453629","url":null,"abstract":"<p><strong>Objective: </strong>Chronic subdural hematoma (CSDH) is a common neurologic disorder with increasing incidence, which can be preceded by head trauma or occur in the absence of trauma. In order to deeply understand the clinical characteristics of this disease, we conducted this retrospective study to explore the clinical differences between traumatic and not otherwise specified (NOS) CSDH.</p><p><strong>Methods: </strong>According to the inclusion and exclusion criteria, 168 traumatic CSDH patients and 133 NOS CSDH patients were recruited from January 2015 to October 2023 in our cohort. The collected data and compared parameters including baseline clinical features and radiological outcomes of hematoma within 24 h of hospital admission, as well as the treatment method and clinical outcome of traumatic and NOS CSDH patients.</p><p><strong>Results: </strong>Compared to NOS CSDH patients, the average age was younger, epilepsy was more frequent, asymptomatic cases were more common, and the taking of anticoagulants and antiplatelet drugs were rarer in traumatic CSDH patients (all <i>P</i> < 0.05). However, no differences were found in the radiological presentations of hematoma at admission, the treatment methods and clinical outcomes of traumatic and NOS CSDH patients (all <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Traumatic CSDH patients were more likely to be asymptomatic or have seizures, while NOS CSDH were more common in elder people and in individuals with the history of taking anticoagulants and antiplatelet drugs. The treatment methods and clinical outcomes were similar in traumatic and NOS CSDH patients.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1453629"},"PeriodicalIF":2.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of low frequency repetitive transcranial magnetic stimulation on motor recovery in subacute stroke patients with different motor evoked potential status: a randomized controlled trial.","authors":"Wenjun Qian, Xiaoyu Liao, Xiaowen Ju, Yaxin Gao, Miao Wu, Chen Xie, Yaoying Zhang, Xianming Long, Surong Qian, Yan Gong","doi":"10.3389/fneur.2024.1460925","DOIUrl":"10.3389/fneur.2024.1460925","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on motor function and cortical excitability in stroke patients with different motor evoked potential (MEP) status.</p><p><strong>Methods: </strong>A total of 80 stroke patients were enrolled in this randomized controlled trial and divided into two groups according to MEP status (- or +) of lesioned hemisphere. Then, each group was randomly assigned to receive either active or sham LF-rTMS. In addition to conventional rehabilitation, all participants received 20 sessions of rTMS at 1 Hz frequency through the active or the sham coil over 4 weeks. Fugl-Meyer Assessment (FMA), National Institutes of Health Stroke Scale (NIHSS), Shoulder Abduction Finger Extension (SAFE) and Barthel Index (BI), bilateral resting motor threshold (rMT), amplitude of Motor evoked potential (MEP) and Central Motor Conduction Time (CMCT), and Interhemispheric asymmetry (IHA) were blindly assessed at baseline, 4 weeks and 8 weeks after treatment, respectively.</p><p><strong>Results: </strong>At 4 weeks after intervention, FMA and NIHSS changed scores in 1 Hz MEP(+) group were significantly higher than those in the other three groups (<i>p</i> < 0.001). After receiving 1 Hz rTMS, stroke patients with MEP(+) showed significant changes in their bilateral cortical excitability (<i>p</i> < 0.05). At 8 weeks after intervention, 1 Hz MEP(+) group experienced higher changes in NIHSS, FMA, SAFE, and BI scores than other groups (<i>p</i> < 0.001). Furthermore, 1 Hz rTMS intervention could decrease unaffected cortical excitability and enhance affected cortical excitability of stroke patients with MEP(+) (<i>p</i> < 0.05). The correlation analysis revealed that FMA motor change score was associated with decreased unaffected MEP amplitude (<i>r</i> = -0.401, <i>p</i> = 0.010) and decreased affected rMT (<i>r</i> = -0.584, <i>p</i> < 0.001) from baseline, which was only observed in the MEP(+) group.</p><p><strong>Conclusion: </strong>The effects of LF-rTMS on motor recovery and cortical excitability were more effective in stroke patients with MEP than those with no MEP.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1460925"},"PeriodicalIF":2.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of subcutaneous injection of botulinum toxin in the treatment of Chinese postherpetic neuralgia compared to analgesics: a systematic review of randomized controlled trials and meta-analysis.","authors":"Hui Wang, Ping Lin","doi":"10.3389/fneur.2024.1479931","DOIUrl":"10.3389/fneur.2024.1479931","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this meta-analysis is to investigate the efficacy and safety of a subcutaneous injection of botulinum toxin in the treatment of postherpetic neuralgia (PHN) compared to analgesics.</p><p><strong>Methods: </strong>We searched PubMed, Cochrane Library, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang for randomized controlled trials (RCTs) from inception to 10 September 2023. The primary clinical outcomes included visual analog scale (VAS) pain scores and clinical effective rates. The secondary clinical outcome included the adverse event rate during follow-up.</p><p><strong>Results: </strong>A total of 14 studies with 1,358 participants were included in the meta-analysis. Among the included patients, 670 participants received botulinum toxin A injections and 688 participants received other medication treatments. The botulinum toxin-A (BTX-A) group exhibited lower pain scores [week 2: Mean difference (MD): -1.91, 95% confidence interval (CI): -2.63 to -1.20, and <i>p</i> < 0.00001; week 4: MD: -1.69, 95% CI: -2.69 to -0.68, and <i>p</i> < 0.00001; week 8: MD: -1.66, 95% CI: -2.20 to -1.12, and <i>p</i> < 0.00001; week 12:MD: -1.83, 95% CI: -2.70 to -0.96, and <i>p</i> < 0.00001; and week 24: MD: -1.07, 95% CI: -1.16 to -0.99, and <i>p</i> < 0.00001]. The effective rate was significantly higher in patients who received BTX-A for postherpetic neuralgia compared to those who received lidocaine or gabapentin (lidocaine: MD: -1.55, 95% CI: -2.84 to -0.27, and <i>p</i> = 0.02 and gabapentin: MD: -1.57, 95% CI: -2.12 to -1.02; and <i>p</i> < 0.00001). There was no difference in the incidence of adverse events between the treatment groups [odds ratio (OR): 1.25, 95% CI: 0.43 to 3.61, and <i>p</i> = 0.69].</p><p><strong>Conclusion: </strong>Our meta-analysis showed that BTX-A has certain advantages in relieving postherpetic neuralgia compared to analgesics. In addition, BTX-A is safe for treating postherpetic neuralgia, with no notable side effects.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42021289813.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1479931"},"PeriodicalIF":2.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular specializations underlying phenotypic differences in inner ear hair cells of zebrafish and mice.","authors":"Kimberlee P Giffen, Huizhan Liu, Kacey L Yamane, Yi Li, Lei Chen, Kenneth L Kramer, Marisa Zallocchi, David Z He","doi":"10.3389/fneur.2024.1437558","DOIUrl":"10.3389/fneur.2024.1437558","url":null,"abstract":"<p><strong>Introduction: </strong>Hair cells (HCs) are the sensory receptors of the auditory and vestibular systems in the inner ears of vertebrates that selectively transduce mechanical stimuli into electrical activity. Although all HCs have the hallmark stereocilia bundle for mechanotransduction, HCs in non-mammals and mammals differ in their molecular specialization in the apical, basolateral, and synaptic membranes. HCs of non-mammals, such as zebrafish (zHCs), are electrically tuned to specific frequencies and possess an active process in the stereocilia bundle to amplify sound signals. Mammalian HCs, in contrast, are not electrically tuned and achieve amplification by somatic motility of outer HCs (OHCs).</p><p><strong>Methods: </strong>To understand the genetic mechanisms underlying differences between adult zebrafish and mammalian HCs, we compared their RNA-seq-characterized transcriptomes, focusing on protein-coding orthologous genes related to HC specialization.</p><p><strong>Results: </strong>There was considerable shared expression of gene orthologs among the HCs, including those genes associated with mechanotransduction, ion transport/channels, and synaptic signaling. However, there were some notable differences in expression among zHCs, OHCs, and inner HCs (IHCs), which likely underlie the distinctive physiological properties of each cell type. For example, OHCs highly express Slc26a5 which encodes the motor protein prestin that contributes to OHC electromotility. However, zHCs have only weak expression of slc26a5, and subsequently showed no voltage-dependent electromotility when measured. Notably, the zHCs expressed more paralogous genes including those associated with HC-specific functions and transcriptional activity, though it is unknown whether they have functions similar to their mammalian counterparts. There was overlap in the expressed genes associated with a known hearing phenotype.</p><p><strong>Discussion: </strong>Our analyses unveil substantial differences in gene expression patterns that may explain phenotypic specialization of zebrafish and mouse HCs. This dataset also includes several protein-coding genes to further the functional characterization of HCs and study of HC evolution from non-mammals to mammals.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1437558"},"PeriodicalIF":2.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor treating induced fields: a new treatment option for patients with glioblastoma.","authors":"Zehao Cai, Zukai Yang, Ying Wang, Ye Li, Hong Zhao, Hanwen Zhao, Xue Yang, Can Wang, Tengteng Meng, Xiao Tong, Hao Zheng, Zhaoyong He, Chunli Niu, Junzhi Yang, Feng Chen, Zhi Yang, Zhige Zou, Wenbin Li","doi":"10.3389/fneur.2024.1413236","DOIUrl":"10.3389/fneur.2024.1413236","url":null,"abstract":"<p><strong>Purpose: </strong>Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.</p><p><strong>Methods: </strong>Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The <i>in-vivo</i> imaging system was utilized to confirm tumor growth in the brains of mice.</p><p><strong>Results: </strong>TTIF significantly inhibited the proliferation of U87 cells both <i>in vitro</i> and <i>in vivo</i>.</p><p><strong>Conclusion: </strong>TTIF significantly inhibited the proliferation of U87 cells both <i>in vitro</i> and <i>in vivo</i>. Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1413236"},"PeriodicalIF":2.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of traditional Chinese exercises on the physical and mental health of stroke patients: a meta-analysis.","authors":"Yan Shao, Jing-Yuan Han, Hai-Long Li, Zhu-Ping Ren, Hui Yang","doi":"10.3389/fneur.2024.1455679","DOIUrl":"10.3389/fneur.2024.1455679","url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis aimed to investigate the effects of traditional Chinese exercises on stroke and explore the dose-response relationship between the type of exercise and exercise duration with respect to physical and mental health.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science, EBSCO, China National Knowledge Infrastructure (CNKI), Wan Fang Database, and China Science and Technology Journal Database to identify published randomized controlled trials (RCTs) related to stroke patients and traditional Chinese exercise that met the evaluation criteria, from the inception of the database until September 2022. After assessing the quality of the literature, we used RevMan5.4 for data analysis.</p><p><strong>Results: </strong>A total of 27 RCTs were included. The results of the meta-analysis revealed that motor function [MD = 4.79, 95% CI: (4.14, 5.43), <i>p</i> < 0.001], balance function [MD = 5.25, 95% CI: (3.93, 6.56), <i>p</i> < 0.001], and mental health [MD = -2.42, 95% CI: (-3.92 to -0.92), <i>p</i> = 0.002] were significantly better in the experimental group than in the control group.</p><p><strong>Conclusion: </strong>Traditional Chinese exercises have a positive effect on the physical and mental health of stroke patients, with the most significant benefit observed in balance function. While traditional Chinese exercises improve exercise capacity and mental health in stroke patients, these improvements are not directly correlated with longer practice time, and there appear to be certain limitations regarding duration.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1455679"},"PeriodicalIF":2.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}