Frontiers in Neurology最新文献

{"title":"Individualized prediction of stroke-associated pneumonia for patients with acute ischemic stroke.","authors":"Lulu Zhang, Qi Wang, Yidan Li, Qi Fang, Xiang Tang","doi":"10.3389/fneur.2025.1505270","DOIUrl":"10.3389/fneur.2025.1505270","url":null,"abstract":"<p><strong>Background: </strong>Stroke-associated pneumonia (SAP) remains a neglected area despite its high morbidity and mortality. We aimed to establish an easy-to-use model for predicting SAP.</p><p><strong>Methods: </strong>Two hundred seventy-five acute ischemic stroke (AIS) patients were enrolled, and 73 (26.55%) patients were diagnosed with SAP. <i>T</i>-test, Chi-square test and Fisher's exact test were used to investigate the associations of patient characteristics with pneumonia and its severity, and multivariable logistic regression models were used to construct a prediction scale.</p><p><strong>Results: </strong>Three variables with the most significant associations, including age, NGT placement, and right cerebral hemisphere lesions combined with gender, were used to construct a stroke-associated pneumonia prediction scale with high accuracy (AUC = 0.93). Youden index of our SAP prediction model was 0.77. The sensitivity and specificity of our SAP prediction model were 0.89 and 0.88, respectively.</p><p><strong>Conclusion: </strong>We identified the best predictive model for SAP in AIS patients. Our study aimed to be as clinically relevant as possible, focusing on features that are routinely available. The contribution of selected variables is visually displayed through SHapley Additive exPlanations (SHAP). Our model can help to distinguish AIS patients of high-risk, provide specific management, reduce healthcare costs and prevent life-threatening complications and even death.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1505270"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study on the treatment of acute epidural hematoma by embolization of middle meningeal artery through radial artery access combined with minimally invasive burr hole drainage.","authors":"Cui Zhang, Qingbo Wang, Chenglong Li, Zixuan Jing, Xinyu Zhao, Yang Chen, Zefu Li","doi":"10.3389/fneur.2025.1502408","DOIUrl":"10.3389/fneur.2025.1502408","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the clinical effectiveness of using coil embolization via radial artery access, combined with drilling and drainage, as a minimally invasive treatment for acute epidural hematoma compared to traditional craniotomy.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on 134 patients with acute epidural hematoma treated at the Department of Neurosurgery, Binzhou Medical University Hospital, between January 2020 and April 2023. Among these patients, 37 underwent embolization of the middle meningeal artery through radial artery access combined with burr hole drainage, while 97 patients underwent craniotomy for hematoma removal. The 37 patients treated with embolization were designated as the experimental group, while the remaining 97 patients formed the control group. General patient characteristics, operation duration, intraoperative blood loss, postoperative complications, and Glasgow Coma Scale (GCS) scores upon admission and discharge were recorded and compared between the two groups.</p><p><strong>Results: </strong>In comparison to the control group, the experimental group exhibited higher rates of postoperative hematoma residuals and longer average postoperative drainage times. Nevertheless, the experimental group demonstrated several advantages including shorter operation durations, reduced intraoperative bleeding, lower rates of postoperative rebleeding and complications, as well as decreased requirements for postoperative blood transfusions and transfusion volumes.</p><p><strong>Conclusion: </strong>The surgical approach involving coil embolization via radial artery access combined with minimally invasive burr hole drainage yields favorable clinical outcomes. This technique presents as a viable treatment option for acute epidural hematoma resulting from middle meningeal artery hemorrhage.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1502408"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal assessment in 143 patients with white matter lesions: the potential of OCTA as an evaluation tool.","authors":"Dong Zhang, Xueying Jiang, Yan Zhang, Jingcui Qin","doi":"10.3389/fneur.2025.1421232","DOIUrl":"10.3389/fneur.2025.1421232","url":null,"abstract":"<p><strong>Background: </strong>The retina is a simple window to reflect the changes of brain nerves. The aim of this study was to investigate the association between retinal status and white matter lesions (WMLs) in 143 patients aged 50-80 years, utilizing Optical Coherence Tomography Angiography (OCTA) and the Fazekas Visual Scale for assessment.</p><p><strong>Methods: </strong>A total of 143 subjects underwent MRI scanning to assess the degree of WMLs using the Fazekas scale. Retinal imaging was conducted utilizing OCTA. Multivariate logistic regression analysis was employed to determine the odds ratios and 95% confidence intervals associated with the Fazekas score for each factor. The relationship between cognitive function and various OCTA parameters was assessed using quadratic and cubic simulation curve models. Data following a normal distribution are presented as means, while non-normally distributed data are reported as medians. Qualitative data are expressed as percentages.</p><p><strong>Results: </strong>As Fazekas grades increased, ILM-IPL thickness (OR = 3.267, OR = 8.436), vessel density in the parafoveal region of the macula, retinal vessel densities (OR = 2.058, OR = 2.363), and RNFL thickness significantly reduced (<i>p</i> < 0.05). With increasing Fazekas scores, the bilateral foveal avascular zone showed a significant increase (OR = 0.362, OR = 0.458) (<i>p</i> < 0.05). Retinal thickness and vascular density were negatively correlated with WMLs, and positively correlated with cognitive function (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The severity of WMLs increases as retinal thickness and vascular density decrease. OCTA examination has a degree of role in screening for WMLs caused by cerebral microvascular disease. Its effectiveness in screening early asymptomatic individuals or those with mild cognitive impairment is somewhat limited.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1421232"},"PeriodicalIF":2.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of two kinds of vestibular function training on reducing motion sickness in college students.","authors":"Linyao Shi, Jing Zhao, Jiamei Lu, Chuanxia Cao, Qikun Zhang, Chuanjing Qiu, Zhanguo Jin, Shengguang Yan","doi":"10.3389/fneur.2025.1433065","DOIUrl":"10.3389/fneur.2025.1433065","url":null,"abstract":"<p><strong>Introduction: </strong>To explore the advantages and disadvantages of different vestibular function training to improve Motion sickness (MS) can be associated with significant symptoms, including fatigue, dizziness, headaches, nausea, and vomiting. Vestibular function training has increasingly replaced MS medications over the past few years and has almost no side effects.</p><p><strong>Methods: </strong>We selected 109 students with MS from a university in Tangshan, China, and randomly assigned them to either an electric rotating chair group or a visual-motion cage rotating chair group. Both training groups underwent vestibular function training for 90 seconds a day for seven consecutive days.</p><p><strong>Results: </strong>After training, both groups' Graybiel scores, blood pressure, high-frequency power (HF), and root mean square of successive differences (rMSSD) between adjacent normal heartbeats significantly decreased. In the visual-motion cage rotating chair group, in addition to a reduction in the percentage of adjacent normal-to-normal intervals which differed by more than 50 ms (pNN50), as well as decreases in low-frequency power (LF), an increase in LF/HF was observed. Between-group comparisons showed that the Graybiel scores in the electric rotating chair group were better than those in the visual-motion cage rotating chair group. When the two groups were stratified into high and low-susceptibility subgroups, the low-susceptibility subgroup of the electric rotating chair group had lower Graybiel scores and diastolic blood pressures than the low-susceptibility visual-motion cage rotating chair subgroup, whereas in the high susceptibility subgroup, LF, rMSSD, and pNN50 were significantly higher in the visual-motion cage rotating chair group than in the electric rotating chair group.</p><p><strong>Discussion: </strong>This study compared the effects of two types of vestibular function training on Graybiel scores and heart rate variability (HRV). we found that seven days of training with both the electric rotating chair and the visual-motion cage rotating chair relieved MS symptoms and enhanced sympathetic regulation. In terms of improving the subjective degree of MS, the electric rotating chair was superior to the visual-motion cage rotating chair. Subgroup analysis results showed that low-susceptibility MS patients' symptoms were better relieved with electric rotating chair training, while high-susceptibility patients' symptoms were better relieved with visual-motion cage rotating chair training.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1433065"},"PeriodicalIF":2.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-based biomarkers in mild behavioral impairment: an updated overview.","authors":"Efthalia Angelopoulou, Xenia Androni, Chiara Villa, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis Papageorgiou","doi":"10.3389/fneur.2025.1534193","DOIUrl":"10.3389/fneur.2025.1534193","url":null,"abstract":"<p><p>Identifying individuals at-risk for dementia is one of the critical objectives of current research efforts, highlighting the need for simple, cost-effective, and minimally invasive biomarkers. Mild behavioral impairment (MBI), characterized by the emergence of persistent neuropsychiatric manifestations in older adults, has attracted increasing attention as a potential early indicator of cognitive decline and dementia. A growing number of studies have recently begun to explore the relationship between MBI and several blood-based biomarkers associated with Alzheimer's disease (AD) pathology, neurodegeneration, as well as systemic metabolic and inflammatory dysregulation. In this context, MBI has been associated with lower plasma Aβ42/Αβ40 ratio, higher plasma phosphorylated tau at threonine 181 (p-tau181), increased neurofilament light chain (NfL) levels, as well as disturbances in metabolic markers, including homocysteine, insulin and ferritin, suggesting a multifaceted neurobiological basis for this syndrome. These findings offer insights into the underlying pathophysiology of MBI, and connection between neuropsychiatric symptoms and progression of AD. In this narrative review, we aim to summarize and critically discuss the emerging literature evidence linking MBI to blood-based biomarkers, hoping to shed more light on MBI's pathophysiology, its connection to AD-related neurobiology, as well as its potential practical utility for predicting cognitive impairment, guiding early interventions and managing the risk for dementia.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1534193"},"PeriodicalIF":2.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: New advances in the field of nerve regeneration.","authors":"Ouwen Qiu, Wenchuan Zhang","doi":"10.3389/fneur.2025.1541159","DOIUrl":"https://doi.org/10.3389/fneur.2025.1541159","url":null,"abstract":"","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1541159"},"PeriodicalIF":2.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary endolymphatic hydrops: a clinical and literature overview.","authors":"Aïna Venkatasamy, Anne R J Péporté","doi":"10.3389/fneur.2024.1525954","DOIUrl":"10.3389/fneur.2024.1525954","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Secondary endolymphatic hydrops (SEH) is a pathologic condition of the inner ear that usually manifests as episodic vertigo and fluctuating hearing loss, overlapping with other temporal bone pathologies and inner ear diseases.</p><p><strong>Methods: </strong>We searched Pubmed and the Cochrane database for English-language studies published through July 2024.</p><p><strong>Results: </strong>Fifty-four relevant studies and reviews were included in this review on secondary endolymphatic hydrops. This review presents a range of the underlying pathologies in endolymphatic hydrops, along with their corresponding radiological findings, while discussing the associated pathophysiological mechanisms. Secondary endolymphatic hydrops may result from cerebellopontine angle tumors, longstanding inner ear conditions, inner ear malformations, intracranial hypotension and recent investigations have highlighted the role of trauma and inflammation as key factors in SEH development.</p><p><strong>Discussion: </strong>Despite the diverse etiologies of SEH, the findings suggest that many of these conditions share a common final pathway in disrupting endolymphatic fluid balance. This review provides a better understanding of the pathophysiology and etiologies of this intricate disease process, thereby facilitating the diagnosis and treatment of the affected patients.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1525954"},"PeriodicalIF":2.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review.","authors":"Yaoguang Guo, Sihan Hu, Shiman Luo, Lang Tu, Yao Tang, Fang Zeng","doi":"10.3389/fneur.2025.1491132","DOIUrl":"10.3389/fneur.2025.1491132","url":null,"abstract":"<p><strong>Objective: </strong>Ischemic stroke represents a leading cause of disability and mortality worldwide, necessitating effective and complementary therapeutic strategies. Electroacupuncture (EA), a modern extension of traditional acupuncture, has garnered attention for its potential neuroprotective effects in ischemic stroke rehabilitation. This meta-analysis and systematic review aim to synthesize current experimental evidence on the efficacy of EA in ischemic stroke models, focusing on neurological outcomes, infarct volumes, and underlying molecular mechanisms.</p><p><strong>Methods: </strong>A comprehensive search was performed across four databases-Cochrane Library, EMBASE, PubMed, and Web of Science-to identify relevant experimental studies that utilized electroacupuncture (EA) as a therapeutic modality for ischemic stroke in animal models. This search encompassed all literature available from the inception of each library through December 2023. Studies were rigorously screened based on predefined inclusion and exclusion criteria. Data on cerebral infarction volume, neurological deficit scores, cellular apoptosis, and molecular pathways were extracted and analyzed.</p><p><strong>Results: </strong>Eleven eligible studies involving 302 animals (151 in EA treatment groups and 151 in control groups) were included. Meta-analysis revealed that EA significantly reduced cerebral infarction volumes [MD = -15.78, 95%CI (-21.40, -10.16), <i>p</i> < 0.05] and TUNEL-positive cells [MD = -26.46, 95%CI (-40.40, -12.51), <i>p</i> < 0.05], indicating reduced apoptosis. Improvements were also noted in neurological deficit scores [MD = -0.59, 95%CI (-0.92, -0.27), <i>p</i> < 0.05] and modified Neurological Severity Scores (mNSS) [MD = -5.68, 95%CI (-7.41, -3.95), <i>p</i> < 0.05], highlighting functional recovery. While the analysis showed no significant effect on caspase-3 densities [MD = -0.39, 95%CI (-0.79, 0.02), <i>p</i> > 0.05], a notable increase in Bcl-2 densities suggested an anti-apoptotic mechanism [MD = -0.73, 95%CI (-1.68, 0.21), <i>p</i> > 0.05]. The heterogeneity of the included studies points to complex underlying mechanisms, potentially involving modulation of apoptotic pathways and cerebral blood flow.</p><p><strong>Conclusion: </strong>This meta-analysis substantiates the neuroprotective potential of EA in ischemic stroke models, primarily through apoptosis modulation and possibly through improved cerebral perfusion. These findings advocate for the integration of EA into stroke rehabilitation protocols and underscore the need for clinical trials to validate its efficacy in human subjects. Our study not only reinforces the therapeutic value of EA but also prompts further investigation into its underlying mechanisms, potentially guiding more effective stroke recovery strategies.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1491132"},"PeriodicalIF":2.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond.","authors":"Aref Yarahmadi, Masoumeh Dorri Giv, Reza Hosseininejad, Azin Rezaie, Narges Mohammadi, Hamed Afkhami, Arastoo Farokhi","doi":"10.3389/fneur.2025.1472679","DOIUrl":"10.3389/fneur.2025.1472679","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to brain dysfunction and nerve damage, resulting in significant morbidity and mortality globally. Affecting ~50 million people annually, TBI's impact includes a high death rate, exceeding that of heart disease and cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, and necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral therapy, and non-invasive brain stimulation, have shown limited efficacy. A comprehensive understanding of vascular components is essential for developing new treatments to improve blood vessel-related brain damage. Recently, mesenchymal stem cells (MSCs) have shown promising results in repairing and mitigating brain damage. Studies indicate that MSCs can promote neurogenesis and angiogenesis through various mechanisms, including releasing bioactive molecules and extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics of MSCs have positioned them as highly desirable cell sources. Extensive investigations have been conducted on the regulatory properties of MSCs and their manipulation, tagging, and transportation techniques for brain-related applications. This review explores the progress and prospects of MSC therapy in TBI, focusing on mechanisms of action, therapeutic benefits, and the challenges and potential limitations of using MSCs in treating neurological disorders.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1472679"},"PeriodicalIF":2.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocrelizumab-induced colitis-critical review and case series from a Romanian cohort of MS patients.","authors":"Ileana Maria Vodă, Vlad Eugen Tiu, Luiza Răuță, Paul Ciucur, Andreea Ioana Mușuroi, Alina Flavia Tomescu, Nicoleta Laura Humă, Florin Dobrițoiu, Elena Terecoasă, Lucian Negreanu, Cristina Tiu","doi":"10.3389/fneur.2025.1530438","DOIUrl":"10.3389/fneur.2025.1530438","url":null,"abstract":"<p><strong>Background: </strong>Widespread use of ocrelizumab, an anti-CD20 monoclonal antibody, for treating patients with multiple sclerosis (MS), has led to an increase in reported adverse events following real-world observation. Among these, drug-induced colitis is a rare, but severe side effect, prompting a recent FDA statement regarding this safety concern. Objectives: We analyzed a cohort of ocrelizumab treated patients in our MS center to evaluate the incidence of drug-induced colitis.</p><p><strong>Methods: </strong>We present a critical review of the available literature on diagnosis and management of anti-CD20 induced colitis and display a case series of 3 suspected patients in our cohort.</p><p><strong>Results: </strong>Two patients met the full criteria for ocrelizumab-induced colitis, while a third partially met the criteria. Following symptomatic treatment and discontinuation of ocrelizumab, the patients showed favorable outcomes.</p><p><strong>Conclusion: </strong>Ocrelizumab-induced colitis is a rare, but severe adverse event. Its incidence may be higher than expected, reaching 1,95% in our cohort of MS patients. Further reporting of such cases is essential to broaden our understanding of this side effect.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1530438"},"PeriodicalIF":2.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}