Frontiers in Neurology最新文献

{"title":"Assessing the impact of moxibustion on colonic mucosal integrity and gut microbiota in a rat model of cerebral ischemic stroke: insights from the \"brain-gut axis\" theory.","authors":"Yi-Xia Ding, Liang-Liang Chen, Kui-Wu Li, Ling Zou, Lu-Min Liao, Xiao-Yu Han, Jie OuYang, Yue-Ping Wu, Wen-Dong Zhang, Hao Ran Chu","doi":"10.3389/fneur.2025.1450868","DOIUrl":"10.3389/fneur.2025.1450868","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to assess the impact of moxibustion on the colonic mucosal barrier and gut microbiota in a rat model of cerebral ischemic stroke (CIS).</p><p><strong>Method: </strong>The CIS rat model was established using the modified Zea Longa suture method. Successfully modeled rats were randomly allocated into a model group and a moxibustion group, with a sham surgery group serving as the control. The moxibustion group received suspended moxibustion at Dazhui (GV 14), Baihui (GV 20), Fengfu (GV 16), and bilateral Tianshu (ST 25) and Shangjuxu (ST 37) acupoints. Neurological function was assessed using the Longa score, and brain infarct size was assessed through 2,3,5-triphenyl tetrazolium chloride staining. Gut microbiota composition was analyzed using 16S rDNA amplification sequencing. Intestinal mucosal permeability was evaluated using the FITC-Dextran tracer method. The serum ET-1 levels and the expression of Occludin and ZO-1 proteins in colonic tissues were also measured.</p><p><strong>Result: </strong>The model group exhibited significantly higher Longa scores, larger brain infarct size, and higher serum FITC-Dextran levels and ET-1 levels when compared with the sham surgery group (<i>p</i> < 0.01). The model group demonstrated decreased expression of Occludin and ZO-1 in colonic tissues (<i>p</i> < 0.01) and changes in gut microbiota structure. When compared to the model group, the moxibustion group demonstrated significantly lower Longa scores, smaller brain infarct size, and lower serum FITC-Dextran levels and ET-1 levels (<i>p</i> < 0.05). Furthermore, the moxibustion group demonstrated decreased inflammatory cell infiltration in colonic tissues, increased expression of Occludin and ZO-1 proteins in colonic tissues (<i>p</i> < 0.05), enhanced gut microbiota structure, and a decreased Simpson index (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Moxibustion can improve the neurological dysfunction in CIS model rats. The mechanism may be associated with the improvement in gut microbiota dysbiosis, reduction in colonic mucosal permeability, and restoration of intestinal mucosal barrier damage.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1450868"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of repetitive transcranial magnetic stimulation in the treatment of chronic pelvic pain syndrome: a scoping review.","authors":"Chunmei Luo, Baocheng Zhang, Jing Zhou, Keqiang Yu, Degui Chang","doi":"10.3389/fneur.2025.1499133","DOIUrl":"10.3389/fneur.2025.1499133","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pelvic pain syndrome is a common condition characterized by persistent symptoms that are difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) is considered a safe treatment option for alleviating chronic pelvic pain, but different stimulation protocols can affect pain relief outcomes. Establishing an optimal stimulation protocol can enhance the uniformity and consistency of rTMS to provide a potentially effective therapeutic intervention. This review sought to systematically review and assess the existing literature on transcranial magnetic stimulation in patients experiencing chronic pelvic pain syndrome, evaluate the therapeutic efficacy, and determine the most effective stimulation protocol.</p><p><strong>Methods: </strong>A comprehensive search was conducted across three databases, supplemented by manual searches. Two researchers independently reviewed and extracted relevant studies and subsequently performed a thorough analysis of all available clinical data.</p><p><strong>Results: </strong>A total of eight studies were ultimately incorporated into the analysis. These comprised two randomized controlled trials, one self-controlled trial, two case reports, and three prospective studies. All studies demonstrated a notable reduction in pain scores post-treatment.</p><p><strong>Conclusion: </strong>rTMS has demonstrated efficacy in alleviating pain in individuals suffering from chronic pelvic pain syndrome. It is regarded as a safe intervention with minimal adverse effects. Nonetheless, the variability observed across studies hindered our ability to conclusively determine the most effective stimulation sites and parameters. Additional research is essential to reduce bias, enhance methodological rigor, and ascertain the optimal conditions and indications for brain stimulation to optimize the therapeutic effectiveness of rTMS.</p><p><strong>Systematic review registration: </strong>https://inplasy.com/projects/, identifier INPLASY2023120112.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1499133"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of short-term tinnitus treatment on cognitive function and neural synchronization.","authors":"Ho Yun Lee, Seung-Ho Shin, Sung Wan Byun","doi":"10.3389/fneur.2025.1478033","DOIUrl":"10.3389/fneur.2025.1478033","url":null,"abstract":"<p><p>We aimed to evaluate the impact of short-term tinnitus treatment on cognitive function and identify the effects of various treatment combinations on cognitive and tinnitus outcomes. A non-randomized prospective study was conducted with 32 tinnitus patients at a tertiary university hospital between May 2022 and May 2024. Patients received treatments, including neuromodulation, diuretics, gabapentin, selective serotonin reuptake inhibitors (SSRI), anxiolytics, muscle relaxants, hearing aids, and counseling. Cognitive function and tinnitus distress were assessed using the Mini-Mental State Examination (MMSE) and Tinnitus Handicap Inventory (THI) at baseline and 1 month after treatment. Quantitative electroencephalogram (qEEG) recordings were analyzed to evaluate changes in neural synchronization using phase-locking value (PLV). Strong correlations were also observed between baseline MMSE and changes in MMSE post-treatment (r = -0.796, <i>p</i> < 0.01) and between tinnitus loudness perception and changes in MMSE (r = 0.458, <i>p</i> < 0.01). After Bonferroni correction, muscle relaxants (<i>p</i> = 0.017) and neuromodulation (<i>p</i> = 0.007) showed significant negative effects on cognitive function, while anxiolytics demonstrated a tendency for negative effects (<i>p</i> = 0.052). Additionally, neither baseline tinnitus loudness nor changes in loudness perception (ΔVAS for loudness) were significantly correlated with ΔTHI after Bonferroni correction (<i>p</i> > 0.05). qEEG analysis showed increased PLV in prefrontal-limbic and parietal-occipital connections in patients with improved THI as well as increased PLV in temporal-limbic connections in patients with improved MMSE scores, indicating enhanced neural synchronization and cognitive resource reorganization. These findings underscore the need for careful consideration of cognitive effects when selecting tinnitus treatments and highlight the importance of targeted multimodal interventions to address both tinnitus distress and cognitive function.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1478033"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, genotypic, and neuropsychological profile in a series of patients with Niemann-Pick type C disease.","authors":"Rita Dos Santos Mendes, Daniel Almeida do Valle, Tiago Dos Santos Bara, Vanessa Furlin, Michelle da Silva Zeny, Mara Lúcia Schmitz Ferreira Santos, Mara L Cordeiro","doi":"10.3389/fneur.2025.1542310","DOIUrl":"10.3389/fneur.2025.1542310","url":null,"abstract":"<p><strong>Background: </strong>Niemann-Pick type C (NPC) disease is a rare neurodegenerative disorder with a wide spectrum of clinical manifestations and genetic variability. This cross-sectional study aimed to comprehensively describe the neuropsychological impact of NPC and investigate its correlation with specific genotypes.</p><p><strong>Results: </strong>Eight patients from six unrelated families were included in this study. Their age at symptom onset ranged between 2 and 16 years, with all patients presenting with ataxia, dysarthria, and cognitive impairment. Following the initiation of miglustat treatment, five patients showed a decrease in the Scale for the Assessment and Rating of Ataxia (SARA) score, whereas three demonstrated subsequent increases. Five patients underwent brain magnetic resonance imaging scans, revealing white matter abnormalities and/or brain volumetric reduction in three cases. Despite the small sample size, the overall cognitive performance of the cohort was significantly below the average. The Family Environment Scale highlighted positive structural patterns, particularly regarding Personal Growth and System Maintenance. Genetic analysis identified five mutations in the <i>NPC1</i> gene that correlated with the severity of impairments and clinical outcomes.</p><p><strong>Conclusion: </strong>This study indicated a consistent association between cognitive and behavioral impairments, with severity correlating with age and specific genetic variants. Notably, one subgroup showed a higher prevalence of psychotic and behavioral symptoms, suggesting a potential link with specific genetic variants.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1542310"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intermittent theta burst stimulation on upper limb motor recovery in early stroke patients: an fNIRS study.","authors":"Menghui Liu, Chunxiao Wan, Chunyan Wang, Xinyi Li","doi":"10.3389/fneur.2025.1542827","DOIUrl":"10.3389/fneur.2025.1542827","url":null,"abstract":"<p><strong>Objective: </strong>To explore the recovery of upper limb motor function and the changes in cortical functional connectivity in patients with early subcortical small infarcts accompanied by severe upper limb motor dysfunction (PESSUM) after intermittent theta burst stimulation (iTBS) via functional near-infrared spectroscopy (fNIRS) and to explore the related mechanisms.</p><p><strong>Methods: </strong>We enrolled 56 subcortical ischemic stroke patients with FMA-UE ≤28 and randomly assigned them to receive either genuine (TG, <i>n</i> = 29) or sham (CG, <i>n</i> = 23) iTBS plus standard rehabilitation over 8 days. fNIRS was used to monitor cerebral HbO, HbD, and HbT concentrations, and RSFC changes were analyzed. The FMA-UE and MBI scores were used to evaluate upper limb motor function and daily activities. Intergroup comparisons were conducted using independent samples t tests, whereas intragroup comparisons were performed using paired samples t tests or Mann-Whitney U tests. The trend of the RSFC changes was analyzed via repeated-measures Analysis of Variance (ANOVA).</p><p><strong>Results: </strong>Both groups showed significant improvements in FMA-UE and MBI scores postintervention (<i>p</i> < 0.001). The TG had higher MBI scores than the CG (<i>p</i> = 0.005). fNIRS revealed accelerated cyclical changes in cortical activity in the TG.</p><p><strong>Conclusion: </strong>iTBS significantly improved motor function and daily living ability in stroke patients, supporting a role for iTBS in promoting neural repair by accelerating cortical recovery cycles. This study provides evidence that iTBS is an effective rehabilitation strategy poststroke.</p><p><strong>Clinical trial registration: </strong>https://www.chictr.org.cn/showproj.html?proj=169674, ChiCTR2200060955.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1542827"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-related immune-inflammatory biomarkers influence the early progression of medial medullary infarction.","authors":"Li-Min Li, Hao Cai","doi":"10.3389/fneur.2025.1528560","DOIUrl":"10.3389/fneur.2025.1528560","url":null,"abstract":"<p><strong>Background: </strong>Medial medullary infarction (MMI) is a rare type of posterior circulation stroke for which accurate prognostication remains a challenge because of the limited predictive ability of the current models. Blood-derived biomarkers may provide valuable insights that extend beyond established prognostic factors. The aim of this study was to identify rapid and accessible biomarkers for predicting the early progression of MMI.</p><p><strong>Methods: </strong>Seventy patients with MMI and 83 sex- and age-matched healthy controls (HCs) were recruited for this study. Among them, 20 patients were allocated to the early progression cohort, and 50 patients were assigned to the nonprogression cohort. The laboratory blood indices were subsequently compared across these different cohorts. Receiver operating characteristic (ROC) curves were used to evaluate the predictive values of blood-derived indicators.</p><p><strong>Results: </strong>The white blood cell (WBC) count, neutrophil count, monocyte count, low-density lipoprotein cholesterol (LDL-C) level, total cholesterol (TC) concentration, WBC-to-high-density lipoprotein cholesterol (HDL-C) ratio (WHR), neutrophil-to-HDL-C ratio (NHR), monocyte-to-HDL-C ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were significantly greater in patients with MMI than in HCs (<i>p</i> < 0.05). The WBC count, neutrophil count, monocyte count, WHR, NHR, MHR, MLR, NLR and PLR were markedly higher in MMI patients with progression than in MMI patients without progression (<i>p</i> < 0.05). ROC curve analysis revealed that the WBC count, neutrophil count, monocyte count, MLR, NLR, PLR, NHR, and WHR were significant predictors of early progression. However, among these factors, the WBC count (AUC = 0.854<i>, p</i> < 0.001), neutrophil count (AUC = 0.878, <i>p</i> < 0.001), NLR (AUC = 0.861, <i>p</i> < 0.001), and NHR (AUC = 0.848, <i>p</i> < 0.001) had the highest levels of accuracy for predicting early progression in patients with MMI.</p><p><strong>Conclusion: </strong>The efficacy of the WBC count, neutrophil count, NLR and NHR is superior in predicting progression in patients with MMI. The current findings suggest that these indicators may serve as reliable, cost-effective, and innovative prognostic markers for MMI.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1528560"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric MOG antibody-positive encephalitis with normal brain magnetic resonance imaging: a new spectrum associated with MOG antibodies?","authors":"Yan Jiang, Ping Yuan, Xiaojie Song, Jiannan Ma, Siqi Hong, Xiujuan Li, Li Jiang","doi":"10.3389/fneur.2025.1537538","DOIUrl":"10.3389/fneur.2025.1537538","url":null,"abstract":"<p><strong>Objective: </strong>To facilitate the accurate identification of clinical characteristics associated with myelin oligodendrocyte glycoprotein (MOG) antibody positive encephalitis in children presenting with normal brain magnetic resonance imaging (MRI) findings.</p><p><strong>Method: </strong>Patients hospitalized at Children's Hospital of Chongqing Medical University from January 2016 to May 2024, who were positive for MOG antibodies and exhibited encephalitis symptoms with normal brain MRI findings, were retrospectively analyzed.</p><p><strong>Results: </strong>A total of 17 patients (7 males and 10 females; mean age: 9.2 ± 2.8 years) were enrolled in the study. The most prevalent clinical symptoms were fever (17/17), with a median duration of 15 days (IQR: 7.5-21 days), headaches (17/17), mild alterations in mental status (17/17), seizures (6/17), vomiting (6/17), decreased binocular vision (2/17), and hemiplegia (1/17). The majority of cases (15/17) exhibited leukocytosis in peripheral blood (mean: 20.63 ± 7.09 × 10⁹/L) accompanied by an elevated neutrophil ratio. C-reactive protein (CRP) and procalcitonin (PCT) levels were normal in 13 patients (13/17). Cerebrospinal fluid (CSF) leukocyte counts were elevated in all patients (median: 82/mm³; IQR: 49-155/mm³). Six patients (6/17) had elevated CSF protein levels (mean: 1.01 ± 0.38 g/L). CSF glucose levels were normal across all patients. Next-generation sequencing of CSF was performed in 10 patients, all yielding negative results. All patients had a serum MOG antibodies titer of ≥1:32, and six children (6/17) had a CSF MOG antibody titer of ≥1:32. All patients showed clinical improvement after immunotherapy. Only one patient (1/17) experienced a relapse.</p><p><strong>Conclusion: </strong>For patients presenting with encephalitis and normal brain MRI findings, early testing for anti-MOG antibody should be considered if they exhibit the following characteristics: (1) persistent fever; (2) elevated peripheral blood white blood cell (WBC) counts, with normal or slightly elevated PCT and CRP levels; (3) mild elevation of CSF WBC counts, normal or mildly elevated protein levels, and normal CSF glucose levels; and (4) ineffectiveness of antibiotic or antiviral therapy. Encephalitis with normal brain MRI may be regarded as a potential new spectrum associated with MOG antibodies, meriting additional exploration and consideration.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1537538"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution magnetic resonance vessel wall imaging in extracranial cervical artery dissection.","authors":"Sai Shao, Guangbin Wang","doi":"10.3389/fneur.2025.1536581","DOIUrl":"10.3389/fneur.2025.1536581","url":null,"abstract":"<p><p>Extracranial cervical artery dissection (eCAD) is the second leading cause of stroke in young and middle-aged adults. Clinical management strategies for eCAD are continuously being explored and optimized, as revealed by the recently published CADISS and TREAT-CAD studies. The type of drug, dosage, and timing of administration can affect the regression of carotid artery dissection and the risk of recurrence of stroke. Based on imaging evidence, it is important to develop individualized treatment strategies for different risk groups. Currently, High-resolution magnetic resonance vessel wall imaging (MR-VWI) technology has made significant progress in the qualitative diagnosis of eCAD, vascular lesion progression, and the assessment of recurring ischemic stroke risk. To better understand the pathogenesis and progression of eCAD using MR-VWI, a comprehensive review is presented here.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1536581"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical efficacy of sacral magnetic stimulation for the treatment of detrusor underactivity.","authors":"Huixian Pan, Chenhao Tang, Chen Song, Junhua Li","doi":"10.3389/fneur.2025.1499310","DOIUrl":"10.3389/fneur.2025.1499310","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to investigate the effectiveness and safety of sacral magnetic stimulation (SMS) in the management of detrusor underactivity (DU).</p><p><strong>Methods: </strong>We retrospectively analyzed 66 patients with detrusor underactivity treated at Hangzhou Third People's Hospital from January 2020 to October 2024, divided into two groups (33 cases each). Both groups had confirmed detrusor underactivity via urodynamic studies. The control group received conventional treatment (medication, catheterization, bladder training), while the observation group received SMS therapy. Urination diaries, urodynamic parameters and self-rating anxiety scale (SAS) were collected before and after the 4-week treatment to evaluate SMS efficacy and safety.</p><p><strong>Results: </strong>All patients in the observation group completed the course of sacral magnetic stimulation without experiencing any serious complications. After treatment, the observation group showed a significant reduction in the number of daily urinations, nocturnal urinations, SAS score and residual urine volume (RUV) (<i>p</i> < 0.05) compared with the control group. There was no statistically significant difference in maximum cystometric capacity (MCC) (<i>p</i> > 0.05). However, improvements were observed in SAS score, Detrusor Pressure at Maximum Flow (Pdet), Bladder Contractility Index (BCI), Maximum urinary Flow Rate (Qmax) and Average Urinary Flow Rate (Qavg) (<i>p</i> < 0.05). The effective rate in the observation group was 78.78%, significantly higher than that in the control group (<i>p</i> < 0.05). Although there was a slight decrease in the effective rate during the 6-month follow-up, the difference was not statistically significant (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>In conclusion, sacral magnetic stimulation therapy has demonstrated effectiveness in improving urinary function in patients with detrusor underactivity while maintaining a high level of safety.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1499310"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of glycolipid metabolism index on complications and mechanical ventilation in intensive care unit patients with intracerebral hemorrhage: a retrospective cohort study using the MIMIC-IV database.","authors":"Yile Zeng, Long Lin, Jianlong Chen, Shengyu Cai, Jinqing Lai, Weipeng Hu, Yiqi Liu","doi":"10.3389/fneur.2025.1516627","DOIUrl":"10.3389/fneur.2025.1516627","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the predictive capability of glycolipid metabolism index (triglyceride-glucose index, TyG; atherogenic index of plasma, AIP; triglyceride to high-density lipoprotein cholesterol ratio, TG/HDL-C; and non-HDL-C to HDL-C ratio, NHHR) for complications and ventilator use in patients with intracerebral hemorrhage (ICH) admitted to the intensive care unit (ICU).</p><p><strong>Methods: </strong>Patients with ICH requiring ICU admission were selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Outcomes assessed included incidence of complications and use of ventilator support. Multivariate logistic regression, receiver operating characteristic (ROC) analysis, and restricted cubic spline were employed to investigate the relationship between glycolipid metabolism index and clinical outcomes in ICH patients.</p><p><strong>Results: </strong>A total of 733 patients were included. Multivariate logistic regression analysis revealed that elevated TyG, AIP, and TG/HDL-C levels were associated with increased incidence of complications and prolonged ventilator use. ROC curve analysis demonstrated that TyG (AUC 0.646) exhibited the strongest predictive ability for multiple complications in ICH patients. Further multiple regression analysis identified TG/HDL-C as an independent predictor of deep vein thrombosis, while TyG, AIP, and TG/HDL-C independently predicted pulmonary embolism, and TyG, AIP, NHHR, and TG/HDL-C independently predicted acute kidney injury. Moreover, ventilator use further heightened the risk of multiple complications in ICU patients with elevated glycolipid metabolism index.</p><p><strong>Conclusion: </strong>Glycolipid metabolism index represent promising and readily accessible biomarkers for predicting multiple complications and ventilator use in ICU patients with ICH.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1516627"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}