Frontiers in Neurology最新文献

{"title":"Relationship between cognitive dysfunction and urinary 8-OHdG levels in children with obstructive sleep apnea.","authors":"Bolin Chen, Jiapeng Ji, Meng Lv, Xueyun Xu, Yuqing Wang","doi":"10.3389/fneur.2025.1502906","DOIUrl":"https://doi.org/10.3389/fneur.2025.1502906","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is a condition characterized by partial or complete obstruction of the upper respiratory tract during sleep, which can result in neurocognitive deficits and cognitive dysfunction in children. Oxidative stress may play a significant role in OSA-related disorders, with 8-hydroxy-2'-deoxyguanosine (8-OHdG) serving as a primary marker of oxidative DNA damage for assessing oxidative stress levels. This study aims to investigate the relationship between urinary 8-OHdG levels in children with OSA and cognitive dysfunction.</p><p><strong>Methods: </strong>The study included children with habitual snoring from April 2023 to June 2024 at the Children's Hospital of Soochow University. All participants completed the PedsQL questionnaire and underwent polysomnography (PSG) assessment and urine collection for 8-OHdG analysis.</p><p><strong>Results: </strong>In total, 99 children with OSA and 35 children with non-OSA were included. The urinary 8-OHdG levels were higher in the OSA group (240.94 ± 11.51 pg./mL) than in the non-OSA group (230.73 ± 13.82 pg./mL) (<i>p</i> < 0.001). Moreover, 8-OHdG was correlated with the course of the disease, obstructive apnea-hypopnea index, minimum arterial oxygen saturation (SaO2), average SaO2, oxygen desaturation index, and cognitive dysfunctions evaluated by the PedsQL questionnaire (all <i>p</i> < 0.05). The area under the receiver operating characteristics curve of 8-OHdG was 0.661 (95%confidence interval, 0.550-0.773). Binary logistic regression analysis revealed that 8-OHdG was significantly associated with the School Functioning score (<i>p</i> = 0.004).</p><p><strong>Conclusion: </strong>Urinary 8-OHdG may serve as a non-invasive, objective biomarker for assessing cognitive dysfunctions in children with OSA.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1502906"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Artificial intelligence and telemedicine: applications to vascular neurology, neuro-ophthalmology, neuro-otology, and epilepsy: advancing teleneurology with artificial intelligence and digital biomarkers.","authors":"Jonathan D Browne, Kemar E Green","doi":"10.3389/fneur.2025.1582142","DOIUrl":"https://doi.org/10.3389/fneur.2025.1582142","url":null,"abstract":"","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1582142"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal thickness is indicative of visual loss in patients with occipital lobe infarction.","authors":"Xueling Bai, Le Cao, Hang Wang, William Robert Kwapong, Yuying Yan, Guina Liu, Junfeng Liu, Fayun Hu, Bo Wu","doi":"10.3389/fneur.2025.1546439","DOIUrl":"https://doi.org/10.3389/fneur.2025.1546439","url":null,"abstract":"<p><strong>Purpose: </strong>We explored the relationship between retinal thicknesses and vessels using optical coherence tomography angiography (OCT)/ OCT angiography (OCTA) and clinical outcomes in occipital lobe infarction (OI).</p><p><strong>Methods: </strong>A total of 52 OI patients and 105 controls underwent macular OCT/OCTA scans covering a 6 × 6 mm² area around the fovea. The retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), superficial vascular complex (SVC), and deep vascular complex (DVC) were measured using the OCT/OCTA tool. All participants underwent a visual acuity examination.</p><p><strong>Results: </strong>OI patients showed reduced GCIPL thickness and lower SVC density but higher DVC density (all <i>p</i> < 0.001) compared to the controls, both in the whole area and across the four sectors. Eyes ipsilateral or contralateral to infarction showed reduced GCIPL thickness and lower SVC density (all <i>p</i> < 0.05). The GCIPL thickness was significantly correlated with the infarct diameter and visual acuity (both <i>p</i> < 0.05), while the SVC density was also significantly correlated with the infarct diameter (<i>p</i> = 0.002). The visual acuity showed a significant association with the infarct diameter (<i>p</i> < 0.001), and the reduction of the GCIPL partially mediated this effect (a proportion of the mediated effect at 15.17%, <i>p</i> = 0.028).</p><p><strong>Conclusion: </strong>GCIPL thinning may account for the effect of infarct diameter on visual acuity in OI patients. Future prospective studies are needed to assess OCT/OCTA as a potential marker of visual loss in OI.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1546439"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of offending vessel location on lateral spread response variations in hemifacial spasm patients.","authors":"Feiyu Ding, Pan Li, Xiaozhou Zuo, Yong Xiao, Dong Wang, Yong Liu, Yuanjie Zou","doi":"10.3389/fneur.2025.1561134","DOIUrl":"https://doi.org/10.3389/fneur.2025.1561134","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the impact of the offending vessel's compression location on intraoperative lateral spread response (LSR) waveform parameters during microvascular decompression (MVD) for hemifacial spasm (HFS). Additionally, the study evaluates the clinical significance of LSR variations in intraoperative electrophysiological monitoring.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 72 patients with HFS who underwent MVD at Nanjing Brain Hospital between September 2021 and September 2023. Patients were categorized into two groups based on the compression site of the offending vessel on the facial nerve: the transitional zone (TZ) group and the attached segment (AS) group. General clinical characteristics, intraoperative LSR parameters, and postoperative outcomes were compared between groups. Statistical analyses focused on LSR latency, amplitude, and duration, as well as the patterns of LSR disappearance and postoperative complications.</p><p><strong>Results: </strong>The TZ group comprised 31 patients, while the AS group included 41. No significant differences were observed in baseline characteristics between groups. Intraoperative monitoring revealed that LSR disappearance was more frequently incomplete in the TZ group (11.1%) than in the AS group (<i>p</i> < 0.05). LSR latency was significantly longer in the AS group (<i>p</i> < 0.001), while the amplitude in the orbicularis oculi muscle was lower in the TZ group (<i>p</i> < 0.001). Additionally, LSR duration (T2) in the orbicularis oris (<i>p</i> < 0.05) and mentalis muscles (<i>p</i> < 0.01) was longer in the AS group, though the amplitude differences were not statistically significant. Postoperative outcomes showed no significant difference in effectiveness between the groups (AS: 92.7% vs. TZ: 93.5%, <i>p</i> = 0.882). Complications, such as facial palsy and hoarseness, were slightly more common in the AS group, whereas hearing loss and ataxia were more frequent in the TZ group. However, none of these differences reached statistical significance.</p><p><strong>Conclusion: </strong>The compression location of the offending vessel significantly influences LSR parameters, with longer latency and prolonged duration observed in the AS group. Despite these variations, postoperative outcomes and complications were comparable between groups. These findings highlight the importance of considering the compression location during MVD and the potential value of LSR monitoring in guiding surgical decision-making.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1561134"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rituximab treatment in Chinese patients with primary angiitis of the central nervous system.","authors":"Yu-Zhen Wei, Hua-Bing Wang, Lin-Lin Yin, Ai Guo, Lu-Lin Zhang, Jia-Li Sun, Ping Lu, Xing-Hu Zhang, De-Cai Tian","doi":"10.3389/fneur.2025.1554989","DOIUrl":"https://doi.org/10.3389/fneur.2025.1554989","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the efficacy and safety of rituximab (RTX) in Chinese patients with primary angiitis of the central nervous system (PACNS).</p><p><strong>Methods: </strong>Herein, we present the outcomes of 8 patients who received RTX for PACNS. Seven patients underwent a brain biopsy showing vasculitis, while the remaining patient had a digital subtraction angiogram and clinical findings highly suggestive of vasculitis. Clinical evaluation, laboratory tests, and imaging modalities were performed during the initial RTX administration and follow-up. The Expanded Disability Status Scale (EDSS) disability score was used to assess treatment response and degree of disability.</p><p><strong>Results: </strong>The median age at diagnosis of the 8 patients (2 females) was 37.0 years. All patients had active disease when RTX treatment was initiated. Five of the eight patients had refractory disease, and received one or more conventional immunosuppressants (IS). Three patients had contraindications or refused conventional IS. Patients were followed up until their death or the final follow-up visit (median 18 months; range: 0-40 months). The median EDSS score at the last visit (median 3.0; range 0-9.5) was lower than before RTX administration (median 6.5; range 1.5-9.5). In 6 patients, RTX administration was associated with a marked reduction in the number of flare-ups. Two of the six patients developed infections: one with pneumonia, and the other with tuberculosis. In one patient, parenchymal gadolinium enhancement persisted, and a new lesion was found following three courses of RTX.</p><p><strong>Conclusion: </strong>Our data suggest that RTX therapy may be an additional treatment option for Chinese patients with PACNS.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1554989"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré Syndrome following weight loss: a review of five diet-induced cases and nineteen bariatric surgery cases.","authors":"Qiong Wu, Fang-Yi Li, Jue Hu, Wei Xu, Tie-Qiao Feng, Hua-Shan Zhou, Zhen Wang, Wen-Gao Zeng","doi":"10.3389/fneur.2025.1557515","DOIUrl":"https://doi.org/10.3389/fneur.2025.1557515","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is a worldwide health concern frequently addressed by weight reduction strategies, including bariatric surgery and restricted diets. While effective, these approaches can result in complications, including Guillain-Barré Syndrome (GBS), a rare but serious autoimmune disorder. This study aims to analyze clinical and neurophysiological features of diet-induced GBS and compare them to cases linked with bariatric surgery.</p><p><strong>Methods: </strong>We retrospectively reviewed medical records of five patients admitted to our institution between August 2012 and August 2022, who developed GBS during active dieting resulting in significant weight loss. Clinical presentations, laboratory results, neurophysiological findings, and nutritional status during treatment were analyzed. Additionally, we performed a literature review comparing these cases with nineteen previously reported instances of bariatric surgery-associated GBS.</p><p><strong>Results: </strong>All five patients exhibited acute, symmetrical limb weakness primarily affecting the lower extremities, accompanied by diminished tendon reflexes. Neurophysiological assessments revealed axonal damage in all cases, and albuminocytologic dissociation was present in two patients. Three patients received intravenous immunoglobulin (IVIG) therapy, while the remaining two underwent nutritional therapy alone. All patients achieved full recovery within 6 months. Notably, the rate of weight loss observed significantly exceeded recommended safe guidelines.</p><p><strong>Discussion: </strong>Rapid and substantial weight loss may play a role in triggering GBS, possibly due to nutritional deficiencies or immune dysregulation. Clinicians should recognize the potential neurological risks associated with aggressive weight-loss strategies. Early diagnosis and appropriate intervention are crucial for favorable outcomes and preventing complications.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1557515"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial stenting with the Neuroform Atlas Stent for symptomatic intracranial atherosclerotic stenosis: a bi-center retrospective analysis including stroke recurrence nomogram.","authors":"Weicheng Peng, Haiyang Ma, Xinli Xiang, Rui Zhao, Meng Lv, Sheng Xu, Yuhua Jiang, Zhiqiang Hu, Feng Guan","doi":"10.3389/fneur.2025.1507339","DOIUrl":"https://doi.org/10.3389/fneur.2025.1507339","url":null,"abstract":"<p><strong>Background: </strong>Intracranial stenting with the Neuroform Atlas Stent is an emerging option for patients with symptomatic intracranial atherosclerotic stenosis (sICAS) who do not respond to intensive medical treatment. However, the efficacy, safety, and risk factors associated with postoperative stroke recurrence remain controversial.</p><p><strong>Methods: </strong>A total of 326 consecutive patients with sICAS treated with intracranial stenting using the Neuroform Atlas Stent were retrospectively analyzed to evaluate the efficacy and safety of the procedure. Patients were randomly assigned to a training set and a validation set in a 7:3 ratio. Significant variables in the univariate logistic analyses were included in the final multivariate logistic regression analyses in the training set. Subsequently, we developed a predictive nomogram for sICAS treated with a Neuroform Atlas Stent to predict the likelihood of stroke recurrence at 6 months.</p><p><strong>Results: </strong>The overall mean stenosis rate of the target artery was 88.85% ± 6.53% before the stenting (T0), 47.58% ± 9.94% at the end of the procedure (T1), and 40.21% ± 7.77% at the 6-month follow-up (T2). The stenosis rate was statistically significant between T0 and T1 (<i>p</i> < 0.01) and between T0 and T2 (<i>p</i> < 0.01). At 6 months postoperatively, 36 patients had a stroke recurrence linked to the target artery. Diabetes, acute ischemic stroke (AIS), plaque burden on vessel wall MRI, enhancement ratio on vessel wall MRI, and stenosis (T1) were independent predictors of stroke recurrence. A predictive nomogram was developed, showing strong predictive capability with the area under the curve of 0.933 for the training set and 0.949 for the validation set.</p><p><strong>Conclusion: </strong>Intracranial stenting with the Neuroform Atlas Stent is a potentially safe and effective treatment for sICAS. Risk factors for recurrent stroke post-procedure include diabetes, current smoker, current drinker, AIS, plaque burden, enhancement ratio, and stenosis (T1).</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1507339"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a web-based dynamic nomogram to predict individualized risk of severe carotid artery stenosis based on digital subtract angiography.","authors":"Jian Huang, Zhuoran Li, Xiaozhu Liu, Lirong Kuang, Shengxian Peng","doi":"10.3389/fneur.2025.1565395","DOIUrl":"10.3389/fneur.2025.1565395","url":null,"abstract":"<p><strong>Objectives: </strong>Delays in diagnosing severe carotid artery stenosis (CAS) are prevalent, particularly in low-income regions with limited access to imaging examinations. CAS is a major contributor to the recurrence and poor prognosis of ischemic stroke (IS). This retrospective cohort study proposed a non-invasive dynamic prediction model to identify potential high-risk severe carotid artery stenosis in patients with ischemic stroke.</p><p><strong>Methods: </strong>From July 2017 to March 2021, 739 patients with ischemic stroke were retrospectively recruited from the Department of Neurology at Liuzhou Traditional Chinese Medical Hospital. Risk factors for severe CAS were identified using the least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression (MLR) methods. The model was constructed after evaluating multicollinearity. The model's discrimination was assessed using the C-statistic and area under the curve (AUC). Its clinical utility was evaluated through the decision curve analysis (DCA) and the clinical impact curve (CIC). Calibration was examined using a calibration plot. To provide individualized predictions, a web-based tool was developed to estimate the risk of severe CAS.</p><p><strong>Results: </strong>Among the patients, 488 of 739 (66.0%) were diagnosed with severe CAS. Six variables were incorporated into the final model: history of stroke, serum sodium, hypersensitive C-reactive protein (hsCRP), C-reactive protein (CRP), basophil percentage, and mean corpuscular hemoglobin concentration (MCHC). Multicollinearity was ruled out through correlation plots, variance inflation factor (VIF) values, and tolerance values. The model demonstrated good discrimination, with a C-statistic/AUC of 0.70 in the test set. The DCA and CIC indicated that clinical decisions based on the model could benefit IS patients. The calibration plot showed strong concordance between predicted and observed probabilities. The web-based prediction model exhibited robust performance in estimating the risk of severe CAS.</p><p><strong>Conclusion: </strong>This study identified six key risk factors for severe CAS in IS patients. In addition, we developed a web-based dynamic nomogram to predict the individual risk of severe CAS. This tool can potentially support tailored, risk-based, and time-sensitive treatment strategies.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1565395"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features, risk factors, and a nomogram for predicting refractory cervicogenic headache: a retrospective multivariate analysis.","authors":"Jiawei Li, Baishan Wu, Xiaochen Wang, Lijuan Zhao, Jie Cui, Jing Liu, Kaikai Guo, Xiaoyu Zhang, Juan Liu","doi":"10.3389/fneur.2025.1531180","DOIUrl":"10.3389/fneur.2025.1531180","url":null,"abstract":"<p><strong>Introduction: </strong>Given the intricate nature and varied symptoms of cervicogenic headache, its treatment can be challenging, potentially leading to refractory cervicogenic headache. We aimed to identify risk factors that could help predict the development of refractory cervicogenic headache in patients with cervicogenic headache.</p><p><strong>Methods: </strong>This is a retrospective cohort study of patients diagnosed with cervicogenic headache between January 1, 2022 and March 1, 2024 who underwent greater occipital nerve block. Data were collected by reviewing patients' medical records and pain questionnaires. Covariates were selected using univariate and multivariate logistic regression analyses. A predictive nomogram model was developed to predict the unresponsiveness of the greater occipital nerves to anesthetic blockade.</p><p><strong>Results: </strong>Of the 82 patients studied, 46 experienced relief from headache following greater occipital nerve blocks, whereas 36 did not. In a multivariate analysis of patients with refractory cervicogenic headache, factors such as C2-C3 sensory loss [odds ratio (OR) = 13.10, 95% confidence interval (CI): 1.45-118.54], bilateral headache (OR = 7.99, 95% CI: 1.36-47.07), having two or more types of pain sources (OR = 5.51, 95% CI: 1.01-30.16), and limited cervical range of motion (>1) (OR = 13.05, 95% CI: 2.28-74.59) were identified as major prognostic indicators of unresponsiveness to greater occipital nerve blocks in cases of large occipital and cervical spine-related factors.</p><p><strong>Conclusion: </strong>Patients with severely limited cervical spine mobility, bilateral headaches, and C2-C3 sensory loss may not respond well to greater and lesser occipital nerve block therapy. Pain originating from multiple sources is typically associated with less favorable outcomes.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1531180"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Exercise and neuroplasticity in Parkinson disease.","authors":"Mark A Hirsch, Ulrik Dalgas, Erwin E H van Wegen","doi":"10.3389/fneur.2025.1587715","DOIUrl":"10.3389/fneur.2025.1587715","url":null,"abstract":"","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1587715"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}