Frontiers in Neurology最新文献

{"title":"Manual head rotation synchronised to a metronome is a feasible and valid method for assessing visually enhanced vestibulo-ocular reflexes and vestibulo-ocular reflex suppression.","authors":"Thomas Ming Hong Chang, Richard H Roxburgh, Rachael L Taylor","doi":"10.3389/fneur.2026.1706773","DOIUrl":"https://doi.org/10.3389/fneur.2026.1706773","url":null,"abstract":"<p><strong>Introduction: </strong>The visually enhanced vestibulo-ocular reflex (VVOR) and vestibulo-ocular reflex suppression (VOR-S) are critical in evaluating vestibular and cerebellar contributions to oculomotor control. This study aimed to investigate the feasibility and reliability of metronome-synchronised, manual head rotation video-oculography for evaluating VVOR and VOR-S in healthy participants. A secondary aim was to determine the effects of head rotation frequency and direction, and participant's age, on VVOR and VOR-S gain and saccades.</p><p><strong>Methods: </strong>Twenty-four healthy individuals aged 20-79 years underwent VVOR and VOR-S assessments performed over a range of frequencies from 0.25 to 1.25 Hz, using a portable ICS Impulse video-oculography device.</p><p><strong>Results: </strong>Good control over the frequency and velocity of head rotation was achieved using the metronome. Correlations with the intended frequency (Spearman's rho) ranged from 0.876 to 0.884. The VVOR gains were all close to 1.0 and were unaffected by age or the frequency of head rotation. Saccade rates for VVOR were low. The VOR-S gains and refixation saccades increased with increasing frequency and there was a small but significant effect of age. Slightly higher gains were recorded for head turns to the right for both the VVOR and VOR-S.</p><p><strong>Discussion: </strong>The findings confirm that use of a metronome can effectively control the frequency and to an extent, the velocity of head rotation, offering a cost-effective alternative to traditional rotational chair testing of the VVOR and VOR-S. The results provide a basis for future research and clinical application as a reference for identifying cerebellar and combined cerebellar and vestibular dysfunction.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1706773"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil extracellular traps in retrieved thrombi and functional outcome after stroke thrombectomy.","authors":"Lizhang Chen, Fayun Hu, Hongbo Zheng, Yanbo Li, Li He","doi":"10.3389/fneur.2026.1779666","DOIUrl":"https://doi.org/10.3389/fneur.2026.1779666","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between neutrophil extracellular traps (NETs) content in retrieved thrombi and 90-day functional outcomes in patients with acute ischemic stroke (AIS) secondary to anterior circulation large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT).</p><p><strong>Methods: </strong>This retrospective study analyzed data from a prospectively maintained cohort of 129 consecutive AIS patients who underwent MT at West China Hospital between January 2023 and October 2024. Retrieved thrombi were stained for citrullinated histone H3 (CitH3) and myeloperoxidase (MPO) using immunofluorescence, and the percentage of positive area was quantified to represent NETs content (% area). Patients were dichotomized into high-NETs and low-NETs groups based on an optimal cutoff determined by receiver operating characteristic (ROC) curve analysis for predicting poor outcome (modified Rankin Scale [mRS] score 3-6). The primary endpoint was functional independence (mRS 0-2) at 90 days. Multivariable logistic regression was employed to identify independent predictors of outcome.</p><p><strong>Results: </strong>The ROC analysis yielded an AUC of 0.644. The optimal cutoff value of defining high NETs content was 2.01%. Among 129 patients (mean age 67.9 years, 48.8% male), 88 (68.2%) were in the high-NETs group. Baseline characteristics were largely comparable, though the high-NETs group had significantly higher admission blood glucose (7.9 vs. 6.7 mmol/L, <i>p</i> = 0.009) and a greater prevalence of atrial fibrillation (65.9% vs. 36.6%, <i>p</i> = 0.002). Despite achieving similarly high rates of successful recanalization (mTICI 2b-3) in both groups (96.6% vs. 97.6%, <i>p</i> = 0.99), patients in the high-NETs group had a significantly lower rate of 90-day functional independence (35.2% vs. 68.3%, <i>p</i> < 0.001). After adjusting for confounding variables, high thrombus NETs content remained a robust independent predictor of a lower likelihood of achieving a good outcome (adjusted Odds Ratio [aOR] = 0.60, 95% CI 0.43-0.84, <i>p</i> = 0.003), along with higher baseline NIHSS (aOR = 0.90, 95% CI 0.84-0.97, <i>p</i> = 0.007) and an increased number of retrieval attempts (aOR = 0.66, 95% CI 0.46-0.96, <i>p</i> = 0.028).</p><p><strong>Conclusion: </strong>Quantitative assessment of NETs in retrieved thrombi may serve as an accessible biomarker to identify patients at high risk of poor functional recovery despite successful recanalization. However, the predictive performance was only moderate (ROC AUC = 0.644). Moreover, infarct core volume was not assessed and thus not incorporated into the statistical models, which may limit interpretation and generalizability. Prospective multicenter validation and studies incorporating infarct core volume are warranted, together with exploration of NET-targeted adjunctive therapies.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1779666"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of Baduanjin versus brisk walking on postural control and multidimensional functions in early-to-mid-stage Parkinson's Disease: a randomized controlled trial.","authors":"Yinhang Sun, Panpan Tian, Yibo Xie, Yanjie Guo, Fengtao Liu, Hongxia Xing","doi":"10.3389/fneur.2026.1792257","DOIUrl":"https://doi.org/10.3389/fneur.2026.1792257","url":null,"abstract":"<p><strong>Introduction: </strong>Baduanjin is a traditional mind-body exercise designed to modulate neural circuits and motor coordination. This study aimed to compare its rehabilitative efficacy against conventional brisk walking on postural control, motor, and non-motor functions in patients with early- to mid-stage Parkinson's disease (PD).</p><p><strong>Methods: </strong>A 12-week randomized controlled trial was conducted with 32 PD patients (Hoehn and Yahr stages 1-2.5). Participants were randomly assigned to either a Baduanjin group or a Brisk Walking group and underwent 40-min training sessions five times weekly. Primary outcomes included the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS-III) and Berg balance scale (BBS). Secondary outcomes included Montreal Cognitive Assessment (MoCA), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Pittsburgh Sleep Quality Index (PSQI), 39-Item Parkinson's Disease Questionnaire (PDQ-39) and objective gait parameters were quantified using wearable sensors during the Timed Up and Go (TUG) test and turning task.</p><p><strong>Results: </strong>After 12 weeks, the Baduanjin group demonstrated significantly greater improvements than Brisk Walking in MDS-UPDRS-III (<i>P</i> < 0.05) and axial subscale improved at 6 weeks (<i>P</i> = 0.038) but not 12 weeks (<i>P</i> = 0.060). No between-group differences occurred in limb subscale or BBS (all <i>P</i> > 0.05).No between-group differences occurred in limb subscale or BBS (all P>0.05). Baduanjin reduced anxiety more at 12 weeks (<i>P</i> = 0.014) and improved cognition at 6 weeks (<i>P</i> = 0.015). Depression improved within Baduanjin only (<i>P</i> = 0.015). Both groups improved sleep and quality of life. Baduanjin showed superior gait parameters including TUG duration, turning time, trunk sagittal angular velocity during sit-to-stand/stand-to-sit; (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Baduanjin training appears to offer greater improvements in motor symptoms compared to conventional brisk walking in patients with early- to mid-stage Parkinson's disease. Its integration of mindful movement and breathing techniques may particularly address core motor deficits in PD, providing a safe, accessible, and culturally acceptable non-pharmacological rehabilitation option.</p><p><strong>Clinical trial registration: </strong>ChiCTR2300069360 [https://www.chictr.org.cn/].</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1792257"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of transcranial sonography-magnetic resonance fusion imaging for Parkinson's disease versus multiple system atrophy-Parkinsonian type.","authors":"Chao Hou, Wei Zhang, Ji-Zhu Xia, Hui Liu, Ming-Xing Li, Wen He, Li-Qing Peng","doi":"10.3389/fneur.2026.1797261","DOIUrl":"https://doi.org/10.3389/fneur.2026.1797261","url":null,"abstract":"<p><strong>Introduction: </strong>Transcranial sonography-magnetic resonance (TCS-MR) fusion imaging shows promise in neurodegenerative diseases, yet current echogenicity assessment methods remain controversial, and its role in differentiating Parkinson's disease (PD) from multiple system atrophy-parkinsonian type (MSA-P) remains unknown.</p><p><strong>Objectives: </strong>This study aims to evaluate the diagnostic and differential value of TCS-MR fusion imaging for PD versus MSA-P.</p><p><strong>Patients and methods: </strong>164 PD, 71 MSA-P, and 118 controls who underwent TCS-MR fusion imaging were prospectively enrolled. Substantia nigra hyperechogenicity (SNH) area was calculated. Three planes, designated as SN1, SN2 and SN3 from fusion images were analyzed using ImageJ for grayscale median and pixel count. ROC curves were employed to assess diagnostic and differential diagnostic power.</p><p><strong>Results: </strong>Statistically significant differences were observed among the three groups concerning SN grades, area of SNH, the ratio of the area of SNH to the midbrain area (S/M), echogenicity of the bilateral SN1, SN3, left SNH, and the maximum echogenicity of SN1, as well as the pixel count of bilateral SNH (<i>p <</i> 0.05). The maximum echogenicity of SN1 and left SN1 demonstrated the highest diagnostic and differential performance for PD, with AUC values of 0.86 and 0.82 (both <i>p <</i> 0.001). Fusion parameters outperformed the SNH area and S/M in both diagnosis and differential diagnosis of PD (Z = 3.84 and 3.71, <i>p <</i> 0.01).</p><p><strong>Conclusion: </strong>TCS-MR fusion imaging demonstrates superior diagnostic and differential performance for PD compared to traditional TCS measurements, suggesting its potential as a novel imaging technique in the diagnosis of PD.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1797261"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does acute-phase acupuncture at Hegu (LI04) promote facial nerve regeneration and upregulation of the PI3K/Akt/mTOR pathway? A hypothesis-generating study in a rabbit crush injury model.","authors":"Jin Song, Jianyun Zhang, Xinsheng He, Zhichun Zhu, Bingyan Liu, Yang Liu, Chen Liang, Binbin Jiang, Kesheng Zhang","doi":"10.3389/fneur.2026.1805719","DOIUrl":"https://doi.org/10.3389/fneur.2026.1805719","url":null,"abstract":"<p><p>This study used the rabbit facial nerve crush injury model to investigate the time-dependent effects of acupuncture at Hegu (LI04) on facial nerve regeneration and regulatory role of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway. Thirty-two New Zealand rabbits with facial nerve crush injury were randomly assigned to four groups (<i>n</i> = 8 each): sham-operated, model, acute-phase acupuncture (treatment initiated immediately after modeling, daily for 10 days), and chronic-phase acupuncture (treatment initiated 7 days after modeling, daily for 10 days). Simone's 10-point scale was used for behavioral assessment on day 1 and day 17 post-modeling. Hematoxylin & Eosin staining was used for histomorphology analysis. PI3K, Akt, and mTOR protein and mRNA expression levels were assessed by immunohistochemistry and RT-qPCR, respectively. Both acute- and chronic-phase acupuncture interventions significantly improved the facial nerve function scores, reduced myelin sheath edema, and upregulated the expression levels of PI3K, Akt, and mTOR compared to the model group. Compared to the chronic-phase intervention, the acute-phase intervention yielded superior functional recovery, more regular nerve fiber arrangement, and stronger upregulation of PI3K, Akt, and mTOR proteins and mRNAs. In this experimental model, acupuncture at Hegu (LI04) was associated with improved repair of facial nerve crush injury, with acute-phase intervention showing greater efficacy than chronic-phase intervention. This time-dependent effect was accompanied by upregulation of the PI3K/Akt/mTOR signaling pathway, suggesting a potential association. However, given the substantial methodological limitations-including the absence of sham controls, lack of electrophysiological validation, and the partial nature of the injury model-these findings provide preliminary experimental evidence that may help inform the design of future clinical studies, rather than serving as confirmatory evidence.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1805719"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of non-invasive brain stimulation on spontaneous neural activity in post-stroke aphasia: a protocol for a coordinate-based meta-analysis of fALFF studies.","authors":"Yao Rao, Jingjing Zhang, Jiawei Ni, Ming Zeng, Jiali Wu, Hui Xu, Zhiwei Zhao, Cong Wang, Chunlei Shan","doi":"10.3389/fneur.2026.1820631","DOIUrl":"https://doi.org/10.3389/fneur.2026.1820631","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Post-stroke aphasia (PSA) is a common and debilitating sequela of stroke that severely impairs quality of life. Non-invasive brain stimulation (NIBS), particularly repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), has increasingly emerged as a promising adjunctive approach for language recovery in patients with PSA. Although accumulating evidence supports the beneficial effects of NIBS on language outcomes, the neural mechanisms underlying these clinical improvements remain incompletely elucidated. Previous meta-analyses in PSA and stroke have synthesized multiple resting-state functional magnetic resonance imaging (rs-fMRI) indices, but no meta-analysis has specifically examined treatment-related fractional amplitude of low-frequency fluctuations (fALFF) changes after NIBS in PSA. This protocol describes a coordinate-based meta-analysis designed to quantitatively synthesize rs-fMRI data, aiming to investigate how NIBS modulates intrinsic neural activity-indexed by fALFF-in patients with PSA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods and analysis: &lt;/strong&gt;Two independent reviewers will conduct a systematic search of the PubMed, Web of Science, Embase, and Cochrane databases for studies published from database inception to December 1, 2025. Eligible studies evaluating the effects of NIBS on fALFF in patients with PSA will be selected based on pre-defined criteria. Only whole-brain voxel-wise fALFF studies reporting stereotactic peak coordinates in standard space will be entered into the primary quantitative AES-SDM analysis; ROI-only studies or studies without usable coordinates will be retained for narrative synthesis. Any discrepancies arising during study selection or data extraction will be resolved through consultation with a third independent reviewer. Neuroimaging reporting quality will be assessed with a customized 20-point checklist, and risk of bias will be evaluated with design-specific tools (RoB 2 for randomized trials and ROBINS-I for non-randomized intervention studies). We will also record studies using other rs-fMRI indices (e.g., ALFF, ReHo, and functional connectivity) during screening to describe the broader evidence base. The primary outcome measures will focus on alterations in specific intrinsic regional neuronal activity assessed via rs-fMRI. The meta-analysis of neuroimaging data will be conducted using Anisotropic Effect Size Seed-Based d Mapping (AES-SDM, version 5.15), while clinical outcome analyses will be performed using RevMan 5.4 software (The Cochrane Collaboration). The reporting of this study will strictly adhere to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study will quantitatively synthesize findings from independent neuroimaging studies to provide comprehensive evidence for identifying the modulation patterns of intrinsic brain activity induced by NIBS ","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1820631"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes and anti-inflammatory mechanisms of nucleus basalis of Meynert deep brain stimulation in Alzheimer's disease.","authors":"Yingchuan Chen, Tingting Du, Tenghong Lian, Yin Jiang, Tianshuo Yuan, Jing Li, Fangang Meng, Anchao Yang, Wei Zhang, Jianguo Zhang","doi":"10.3389/fneur.2026.1773910","DOIUrl":"https://doi.org/10.3389/fneur.2026.1773910","url":null,"abstract":"<p><strong>Aim: </strong>Deep brain stimulation of the nucleus basalis of Meynert (NBM-DBS) represents an emerging therapeutic strategy for Alzheimer's disease (AD), yet clinical outcomes have been inconsistent and its mechanistic underpinnings are not fully elucidated. This study aimed to assess the cognitive and psychobehavioral effects of NBM-DBS and to explore its potential impact on systemic inflammatory markers.</p><p><strong>Methods: </strong>In this open-label trial, nine individuals with moderate-to-severe AD underwent bilateral NBM-DBS. Six participants (four with moderate and two with severe AD) completed the full 12-month protocol, which included serial neuropsychiatric assessments and serum cytokine profiling.</p><p><strong>Results: </strong>Stratification by baseline disease severity revealed divergent cognitive trajectories. Patients with moderate AD (CDR = 2) maintained their preoperative performance on the Montreal Cognitive Assessment (MoCA) and Boston Naming Test (BNT) over the 12-month follow-up. In contrast, patients with severe AD (CDR = 3) experienced significant decline on these measures. Serum analyses demonstrated a significant immunomodulatory effect, characterized by elevated levels of the anti-inflammatory cytokines IL-10 and IL-27, and reduced levels of the pro-inflammatory chemokines CXCL10 and RANTES at the 12-month timepoint.</p><p><strong>Conclusion: </strong>Our findings indicate that NBM-DBS may be associated with stabilization of cognitive function in patients with moderate AD, potentially through the modulation of inflammation. The therapeutic benefit appears to be more pronounced in the moderate stage of the disease.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1773910"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in music therapy for neurological rehabilitation.","authors":"Miao Yu, Yuxuan Song, Haochong Song, Haoyang Duan, Guodong Zhang","doi":"10.3389/fneur.2026.1821915","DOIUrl":"https://doi.org/10.3389/fneur.2026.1821915","url":null,"abstract":"<p><p>This review systematically examines the advances, mechanisms, and clinical applications of music therapy in neurorehabilitation. The article first delineates the conceptual origins of music therapy and the developmental trajectory of neurologic music therapy, introducing the major technical classifications including receptive methods, active methods, improvisational approaches, and vibroacoustic music therapy. The core section elaborates on the multidimensional mechanisms underlying music therapy in neurorehabilitation, encompassing neuroanatomical networks, neurotrans Melodic Intonation Therapy and endocrine systems, neuroplasticity, and psychobehavioral dimensions, elucidating the functional recovery pathways through auditory-motor integration, neural network reorganization, and neuroplasticity enhancement. Regarding clinical applications, the article comprehensively discusses the specific implementations and evidence-based efficacy of music therapy in the rehabilitation of stroke, Parkinson's disease, and cerebral palsy, including improvements in motor, speech, and cognitive impairments. Finally, the article summarizes current challenges and outlines future directions, aiming to provide theoretical foundations and practical references for the standardized and precision application of music therapy in neurorehabilitation.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1821915"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal timing of endovascular treatment for symptomatic intracranial atherosclerotic stenosis: a real world single center study.","authors":"Yang Yang, Xiaoya Wang, Jialiang Lu, Ye Li, Lili Zhao, Yating Jian, Tao Li, Meijuan Dang, Ziwei Lu, Fangcun Li, Fan Tang, Qingyu Fan, Ning Bu, Huqing Wang, Ru Zhang, An Wen, Guilian Zhang, Hong Fan, Lei Zhang","doi":"10.3389/fneur.2026.1749046","DOIUrl":"https://doi.org/10.3389/fneur.2026.1749046","url":null,"abstract":"<p><strong>Objective: </strong>To determine the optimal timing of endovascular treatment for acute cerebral infarction with symptomatic intracranial atherosclerotic stenosis (sICAS) in real world practice.</p><p><strong>Methods: </strong>This retrospective single center study enrolled consecutive sICAS patients undergoing intervention. According to the interval from symptom onset to intervention, patients were divided into early (≤14 days) and delayed (>14 days) intervention groups. Primary outcomes were any stroke or death within 30 days and the 90-day mRS score. Secondary analyses explored factors influencing surgical timing.</p><p><strong>Results: </strong>Among 211 eligible patients, 174 were analyzed, including 53 patients in the early intervention group and 121 patients in the delayed intervention group. The 30-day stroke or death rates were 11.3 and 8.3%, and unfavorable 90-day outcomes were 18.9 and 10.7% in the early and delayed groups (<i>p</i> = 0.521, 0.145). Higher preoperative NIHSS, higher albumin-to-globulin ratio, and higher LDL might be independent factors influencing the doctors' decision on the timing of the intervention (OR = 0.819, 0.149, 0.394; <i>p</i> = 0.027, 0.042, 0.004). Thresholds favoring early intervention were NIHSS ≤ 3, albumin-to-globulin ratio < 1.53, and LDL < 2.85 mmol/L (AUC = 0.664, 0.603, 0.642; <i>p</i> = 0.001, 0.030, 0.003). For posterior circulation lesions, early intervention might led to more unfavorable outcomes than delayed intervention (29.2% vs. 8.2%, <i>p</i> = 0.033).</p><p><strong>Conclusion: </strong>In anterior circulation sICAS with minor stroke (NIHSS ≤ 3), high Alberta stroke program early CT score (ASPECTS)/posterior circulation ASPECTS (pcASPECTS) (8-9), and well-controlled LDL, intervention timing may not be restricted, whereas Basilar artery (BA) lesions appear better suited for delayed intervention. Multiple parallel severe stenoses, severe pre-existing global brain injury, and plaque high-signal intensity did not influence on the surgical timing. The conclusions of this study should be validated in future prospective studies.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1749046"},"PeriodicalIF":2.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of factors and pathways related to rehabilitation motivation in stroke patients based on self-determination theory.","authors":"Xuan Wang, Yanfei Hu, Rui Wang, Xiaolu Wei, Qian Shao, Qian Su","doi":"10.3389/fneur.2026.1789949","DOIUrl":"https://doi.org/10.3389/fneur.2026.1789949","url":null,"abstract":"<p><strong>Objectives: </strong>Based on self-determination theory, this study investigates the current state of rehabilitation motivation among stroke patients and its psychosocial correlates, providing evidence for developing a motivation-enhancing intervention model.</p><p><strong>Methods: </strong>Using convenience sampling, 430 stroke patients were recruited from the inpatient wards of the neurology, neurosurgery, and rehabilitation medicine departments at two Grade A Level 3 hospitals in Lanzhou. Data collection employed a demographic questionnaire, Stroke Rehabilitation Motivation Scale, Social Support Rating Scale, General Self-Efficacy Scale, Hospital Anxiety and Depression Scale, and Craig Hospital Inventory of Environmental Factors. Descriptive analysis, correlation analysis, and multiple linear regression analysis were performed using SPSS 26.0, while structural equation modeling was constructed with AMOS 28.0.</p><p><strong>Results: </strong>The mean rehabilitation motivation score for stroke patients was (105.73 ± 22.03) points, indicating a moderately high level. Multivariate linear regression analysis revealed that monthly household income, family relationships, employment status, rehabilitation duration, self-efficacy, social support, anxiety-depression, and environmental factors were significant predictors of rehabilitation motivation (<i>p</i> < 0.05), explaining 70.4% of total variance. The results of the structural equation modeling indicated that social support (<i>β</i> = 0.17, <i>p</i> = 0.002) and self-efficacy (<i>β</i> = 0.132, <i>p</i> < 0.001) showed a direct positive association with the rehabilitation motivation of stroke patients, while anxiety and depression (<i>β</i> = -0.285, <i>p</i> < 0.001) and environmental factors (<i>β</i> = -0.496, <i>p</i> < 0.001) showed a direct negative association with the level of rehabilitation motivation among stroke patients, while self-efficacy and anxiety and depression demonstrated a significant indirect effect in the relationship between social support and environmental factors, consistent with a mediational role.</p><p><strong>Conclusion: </strong>Rehabilitation motivation in stroke patients is influenced by multifaceted factors. It is recommended to implement family-centered, psychosocially integrated motivational intervention strategies, incorporating digital technology to enhance the rehabilitation experience and optimize the rehabilitation support system.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1789949"},"PeriodicalIF":2.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}