Frontiers in Neurology最新文献

{"title":"Machine learning-driven prediction model for cuproptosis-related genes in spinal cord injury: construction and experimental validation.","authors":"Yimin Zhou, Xin Li, Zixiu Wang, Liqi Ng, Rong He, Chaozong Liu, Gang Liu, Xiao Fan, Xiaohong Mu, Yu Zhou","doi":"10.3389/fneur.2025.1525416","DOIUrl":"https://doi.org/10.3389/fneur.2025.1525416","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal cord injury (SCI) severely affects the central nervous system. Copper homeostasis is closely related to mitochondrial regulation, and cuproptosis is a novel form of cell death associated with mitochondrial metabolism. This study aimed to explore the relationship between SCI and cuproptosis and construct prediction models.</p><p><strong>Methods: </strong>Gene expression data of SCI patient samples from the GSE151371 dataset were analyzed. The differential expression and correlation of 13 cuproptosis-related genes (CRGs) between SCI and non-SCI samples were identified, and the ssGSEA algorithm was used for immunological infiltration analysis. Unsupervised clustering was performed based on differentially expressed CRGs, followed by weighted gene co-expression network analysis (WGCNA) and enrichment analysis. Three machine learning models (RF, LASSO, and SVM) were constructed to screen candidate genes, and a Nomogram model was used for verification. Animal experiments were carried out on an SCI rat model, including behavioral scoring, histological staining, electron microscopic observation, and qRT-PCR.</p><p><strong>Results: </strong>Seven CRGs showed differential expression between SCI and non-SCI samples, and there were significant differences in immune cell infiltration levels. Unsupervised clustering divided 38 SCI samples into two clusters (Cluster C1 and Cluster C2). WGCNA identified key modules related to the clusters, and enrichment analysis showed involvement in pathways such as the Ribosome and HIF-1 signaling pathway. Four candidate genes (SLC31A1, DBT, DLST, LIAS) were obtained from the machine learning models, with SLC31A1 performing best (AUC = 0.958). Animal experiments confirmed a significant decrease in the behavioral scores of rats in the SCI group, pathological changes in tissue sections, and differential expression of candidate genes in the SCI rat model.</p><p><strong>Discussion: </strong>This study revealed a close association between SCI and cuproptosis. Abnormal expression of the four candidate genes affects mitochondrial function, energy metabolism, oxidative stress, and the immune response, which is detrimental to the recovery of neurological function in SCI. However, this study has some limitations, such as unidentified SRGs, a small sample size. Future research requires more in vitro and in vivo experiments to deeply explore regulatory mechanisms and develop intervention methods.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1525416"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends and hotspots in exercise therapy for insomnia research: bibliometric and visual analysis.","authors":"Liang Li, Jiuzhu Liang, Tonggang Fan","doi":"10.3389/fneur.2025.1412152","DOIUrl":"https://doi.org/10.3389/fneur.2025.1412152","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzes trends and hotspots in the research on exercise for insomnia using bibliometric methods and visually presents key information in the field.</p><p><strong>Methods: </strong>Using Web of Science Core Collection as a source of literature, Microsoft Excel 2019, CiteSpace, VOSviewer, and the Bibliometrix package based on R language software were used to create visualization graphs and analyze the publications by country and region, institution, journal, author, reference, and keyword.</p><p><strong>Results: </strong>This study included 1,419 papers. The overall number of publications showed an increasing trend, and the highest number of papers in this field were published by the United States and China by country, the University of California System in the United States by institution, and Markus Gerber from Switzerland by author. The trends and hotspots in this field identified through keyword analysis include \"insomnia,\" exercise,\" \"depression,\" \"older adults,\" and \"quality of life.\"</p><p><strong>Conclusion: </strong>The research field of exercise therapy for insomnia is receiving increasing attention, and this study provides a clear and intuitive reference for researchers.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1412152"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of negative emotions and sleep quality in gastric cancer patients and intervention strategies.","authors":"Gang Wang, Quanquan Zhang, Shengjie Pan","doi":"10.3389/fneur.2025.1536736","DOIUrl":"https://doi.org/10.3389/fneur.2025.1536736","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the prevalence of negative emotions and sleep disturbances in gastric cancer patients, explores their relationship, and suggests targeted interventions to enhance their physical and mental well-being.</p><p><strong>Methods: </strong>A total of 650 gastric cancer patients from the First Affiliated Hospital of Soochow University (March 2020 to March 2023) were included. Negative emotions, including anxiety and depression, were assessed using the Positive and Negative Affect Schedule (PANAS), while sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Descriptive statistics and Pearson correlation analysis were employed to analyze the data and explore the relationship between negative emotions and sleep quality.</p><p><strong>Results: </strong>Of the 650 patients, 533 (82%) exhibited negative emotions, and 560 (86.15%) experienced sleep disturbances. A significant positive correlation was found between negative emotion scores and sleep quality (r = 0.682, <i>p</i> < 0.05). Patients with poor sleep quality had significantly higher negative emotion scores (<i>p</i> < 0.05). Factors such as gender, age, tumor stage, and education level influenced negative emotion scores, while room type significantly impacted sleep quality (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Negative emotions and sleep disturbances are common and interrelated in gastric cancer patients. Addressing psychological factors, particularly anxiety and depression, is crucial for improving sleep quality and overall recovery. Integrated psychological and sleep management interventions should be incorporated into routine care to improve patients' quality of life and treatment outcomes.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1536736"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye movement and pupillary response abnormalities measured using virtual reality as biomarkers in the diagnosis of early-stage Parkinson's disease.","authors":"Jing Zhao, Chong Shi, Xucheng Zhang, Shaochen Ma, Wei Sun, Feng Tian, Peifu Wang, Jilai Li, Jichen Du, Xingquan Zhao, Zhirong Wan","doi":"10.3389/fneur.2025.1537841","DOIUrl":"https://doi.org/10.3389/fneur.2025.1537841","url":null,"abstract":"<p><strong>Objective: </strong>Characteristic ocular symptoms are expected to serve as potential biomarkers for early diagnosis of Parkinson's disease (PD). However, possible ocular impairments in PD patients are rarely studied. The study aimed to investigate eye movement characteristics and pupil diameter changes in early-stage PD patients using virtual reality (VR)-based system and explore their contribution in the diagnosis of early-stage PD.</p><p><strong>Methods: </strong>Forty-three early-stage PD patients and 25 healthy controls were included. Eye movements and pupillary response of all subjects were recorded and evaluated by wearing VR glasses. All subjects completed pro-saccade and anti-saccade tasks. Saccadic eye movement and pupillary response parameters were analyzed. Random Forests method was used for classification task, the performance of the classification model in differentiating early-stage PD patients from healthy controls were evaluated.</p><p><strong>Results: </strong>PD patients exhibited reduced pro-saccade velocity and accuracy, longer average time to complete the pro-saccade, and lower anti-saccade error correction rate than healthy controls (all <i>p</i> < 0.05). Significant differences were found in the trajectories of changes in pupil diameter between the two groups. After extraction of frequency-amplitude features of pupil constriction from the spectra of the eye movement signals of PD patients, it can be seen that the amplitudes of movement signals of both the left and right eyes at different frequencies during pro-saccade and anti-saccade tasks were significant. The number of significant amplitude frequencies in both eyes at low (0-6 Hz), medium (7-12 Hz) and high frequencies (13-19 Hz) was 23, 9, and 16, respectively, during pro-saccade task, which was 10, 29, and 43, respectively, during anti-saccade task. The model with all features achieved an accuracy of up to 79%.</p><p><strong>Conclusion: </strong>This study presents a non-invasive approach toward the diagnosis of early-stage PD with VR technology. Eye movement and pupillary response abnormalities measured using VR may be used as effective biomarkers for the diagnosis of early-stage PD.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1537841"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparities in cognitive impairment across neurological autoimmune disorders: a systematic review.","authors":"Rahma Ouled Toumi, Chalachew Kassaw, Valeriia Demareva","doi":"10.3389/fneur.2025.1555407","DOIUrl":"https://doi.org/10.3389/fneur.2025.1555407","url":null,"abstract":"<p><strong>Introduction: </strong>Neurological autoimmune disorders (NADs) often intertwine with cognitive impairment (CI), representing a multi-layered challenge in both clinical understanding and therapeutic management. The compounded burden of NADs and CI not only significantly affects patient's quality of Life (QoL), condition's prognosis, and treatment outcomes, but disproportionately impacts women, who are inherently more susceptible to autoimmunity. This review endeavors to investigate gender-based cognitive deficits, their underlying mechanisms, and their clinical implications. We will focus on Hashimoto's thyroiditis (HT), Graves' disease (GD), fibromyalgia (FMS), Guillain-Barré syndrome (GBS), myasthenia gravis (MG), multiple sclerosis (MS), and narcolepsy type 1 (NT1).</p><p><strong>Methods: </strong>A systematic search of PubMed and the Cochrane Library was conducted for peer-reviewed articles published in the last decade. The search included the keywords \"cognitive impairment,\" \"cognitive decline,\" \"gender disparities,\" \"neurological autoimmune disorders,\" \"Hashimoto's thyroiditis,\" \"graves' disease,\" \"multiple sclerosis,\" \"fibromyalgia,\" \"Guillain-Barre syndrome,\" \"myasthenia gravis,\" and \"narcolepsy type 1″. A manual search also took place to uncover grey literature and additional studies we already know exist that did not appear in the two main databases. After applying inclusion and exclusion criteria, 14 articles were selected for analysis. These articles were evaluated for their contribution to unraveling gender-based cognitive impairment trends across NADs and the possible factors involved.</p><p><strong>Results: </strong>The systematic search yielded a limited number of relevant studies addressing gender disparities in CI across NADs and, apart from MS, most conditions remain under-researched, indicating a significant research gap. While evidence suggests gender-based differences in the manifestations and severity of CI, these findings highlight the necessity for further investigations and innovative clinical approaches tailored to these distinctions.</p><p><strong>Conclusion: </strong>CI remains a critical, underexplored aspect of NADs, with gender disparities receiving even less attention. Our review highlights a research imbalance and a lack of specific investigations, leading to overgeneralized conclusions about CI across NADs and a limited understanding of the various involved mechanisms. Clinically, addressing CI in NADs requires comprehensive cognitive assessments that account for gender differences, alongside equitable access to resources and personalized treatment approaches. Future advancements are likely to revolve around diagnostic innovations, precision medicine, interdisciplinary collaborations, and holistic approaches to chronic disease management.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1555407"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of poor outcomes in patients with intracerebral hemorrhage.","authors":"Liling Zeng, Qixin Zhang, Zhangyong Xia, Wanzhen Cui, Jianwen Guo","doi":"10.3389/fneur.2025.1517760","DOIUrl":"https://doi.org/10.3389/fneur.2025.1517760","url":null,"abstract":"<p><strong>Objective: </strong>To identify the predictors of 3-month outcomes in Chinese patients with intracerebral hemorrhage (ICH) receiving conservative management.</p><p><strong>Methods: </strong>From October 2013 to May 2016, a total of 5,589 individuals with ICH were screened as part of the CRRICH study (Clinical re-evaluation of removing blood stasis therapy in treating acute intracerebral hemorrhage). Of these, 319 patients were ultimately enrolled. This study constitutes a post analysis of the CRRICH study. Potential predictors of poor outcomes following spontaneous ICH, initially identified through univariate analysis, were further evaluated using an unconditional multiple logistic regression model. Poor outcomes were defined as a modified Rankin scale score > 2 at 90 days post-ICH.</p><p><strong>Results: </strong>Of the 319 patients (mean age 62.46 ± 0.71 years; male/female ratio 1.8:1), 89 (27.9%) had poor 3-month outcomes. Multivariable analysis showed increased odds of poor outcomes with older age (odds ratio [OR] 1.05; 95% confidence interval [CI] 1.02-1.08; <i>p</i> < 0.001), right hemispheric hemorrhage (OR 2.41; 95% CI 1.26-4.60; <i>p</i> = 0.008), intraventricular hemorrhage (OR 3.70; 95% CI 1.80-7.61; <i>p</i> < 0.001), and a higher National Institutes of Health Stroke Scale score (NIHSS) (OR 1.21; 95% CI 1.14-1.29; <i>p</i> < 0.001). Conversely, higher body mass index (BMI) (OR 0.88; 95% CI 0.77-0.99; <i>p</i> = 0.015) and shorter symptom-to-admission time (OR 0.77; 95% CI 0.62-0.97; <i>p</i> = 0.025) were associated with reduced odds of poor outcomes.</p><p><strong>Conclusion: </strong>In conservatively treated ICH patients, right hemispheric involvement, ventricular hemorrhage, older age, and higher NIHSS score increased poor outcome risks at 3 months, while higher BMI and early admission reduced risks, aiding clinical prognosis prediction.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1517760"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific brain morphological and network differences in patients showing Parkinson's disease with and without possible rapid eye movement sleep behavior disorder.","authors":"Yang Liu, Pengfei Zhang, Hao Li, Liang Zhou, Jingqi Jiang, Yanli Jiang, Kai Ai, Guangyao Liu, Jing Zhang","doi":"10.3389/fneur.2025.1561555","DOIUrl":"https://doi.org/10.3389/fneur.2025.1561555","url":null,"abstract":"<p><strong>Background: </strong>Sex is a crucial determinant in the clinical manifestations of diseases. However, previous studies have not clarified whether altered brain morphology shows sex-specific patterns in patients with Parkinson's disease (PD) with or without possible rapid eye movement sleep behavior disorder (RBD). This study aimed to investigate sex-specific differences in the patterns of morphological changes among different subgroups of PD.</p><p><strong>Methods: </strong>High-resolution T1-weighted magnetic resonance imaging and clinical scale data were collected from 278 participants in the Parkinson's disease Progression Marker Initiative database: 93 patients with PD-pRBD (60 males, 33 females), 114 patients showing PD without RBD (PDnon-pRBD group; 68 males, 46 females), and 71 healthy controls (HCs; 44 males, 17 females). The Computational Anatomy Toolbox (CAT) 12 was utilized to collect data on gray matter volume (GMV) and cortical morphological metrics. Subsequently, individual-level morphological similarity networks were constructed on the basis of these cortical metrics. Finally, the topological properties of the network were analyzed using graph theoretical methods.</p><p><strong>Results: </strong>In the PD-pRBD group, the GMV in the frontal and temporal lobes of males was lower than that of females. In contrast, the gyrification index (GI) of the frontal lobe in males was lower than that in females within the PDnon-pRBD group. Network analyses based on graph theory revealed that male PD-pRBD patients showed lower network information integration than female patients, particularly in terms of the global properties of fractal dimension (FD) networks. Moreover, in the PD-pRBD group, male patients showed a strong correlation between morphological network metrics and cognitive performance, as measured by the Hopkins Verbal Learning Test-Revised (HVLT<i>-</i>R) memory scores.</p><p><strong>Conclusion: </strong>The presence of more significant sex-related differences in brain morphological changes in the PD-pRBD group in comparison with the PDnon-pRBD group highlights the importance of considering sex-related differences in the diagnosis and management of patients with PD-pRBD.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1561555"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed ischemic stroke after PED placement for aneurysms: optimal duration of dual antiplatelet therapy and risk factors.","authors":"Chao Wang, Yangyang Zhou, Ying Zhang, Dachao Wei, Mirzat Turhon, Jian Liu, Yisen Zhang, Kun Wang, Hongqi Zhang, Tianxiao Li, Aisha Maimaitili, Guohua Mao, Donglei Song, Yunyan Wang, Wenfeng Feng, Yang Wang, Huaizhang Shi, Jieqing Wan, Jianmin Liu, Sheng Guan, Yuanli Zhao, Wenqiang Li, Xinjian Yang","doi":"10.3389/fneur.2025.1561965","DOIUrl":"https://doi.org/10.3389/fneur.2025.1561965","url":null,"abstract":"<p><strong>Background: </strong>Delayed ischemic stroke (DIS) is a rare complication that may occur in patients with cerebral aneurysms treated with the Pipeline Embolization device (PED). This study aims to evaluate the characteristics of DIS following PED placement and to investigate the optimal duration of dual antiplatelet therapy (DAPT) in relation to the incidence of DIS.</p><p><strong>Methods: </strong>We conducted a multicenter retrospective cohort study on consecutive cases of intracranial aneurysms treated with PED. Patients were divided into two groups based on the timing of DAPT switching to monotherapy: early (<6 months) and late (≥6 months). To adjust for potential biases between the groups, inverse probability of treatment weighting (IPTW) was applied. Kaplan-Meier survival analysis and multivariate Cox regression were used to calculate cumulative DIS rates, and risk factors for DIS.</p><p><strong>Results: </strong>A total of 1,146 consecutive patients with 1,296 aneurysms were included, of whom 12 (0.96%) who received PED developed DIS. The late-switch group had a lower DIS rate compared to the early-switch group [0.5% (4 of 752 patients) vs. 2.0% (8 of 394 patients), <i>p</i> = 0.018], even after IPTW. Hypertension [hazard ratio (HR) 3.47, 95% CI: 1.045-11.552] and complete occlusion immediately post-procedure (HR 5.48, 95% CI: 3.048-9.868) were significant risk factors for DIS.</p><p><strong>Conclusion: </strong>DIS is a rare complication among patients treated with PED for cerebral aneurysms. Extending the duration of DAPT to at least six months may safer for the patients with hypertension and immediate complete occlusion.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1561965"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency ablation of the sinuvertebral nerve for patients with discogenic low back pain following lumbar interbody fusion: a case series study.","authors":"Lijie Wang, Jie Lu, Hongyan Wang, Liangliang He, Zhi Dou, Wenxing Zhao, Song Yang, Dong Liu, Liqiang Yang","doi":"10.3389/fneur.2025.1539971","DOIUrl":"https://doi.org/10.3389/fneur.2025.1539971","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the clinical value of radiofrequency ablation (RFA) of the sinuvertebral nerve (SVN) in the treatment of discogenic low back pain (DLBP) following lumbar interbody fusion.</p><p><strong>Methods: </strong>A total of 12 patients who underwent RFA of the SVN for DLBP after lumbar interbody fusion at the Pain Department of Xuanwu Hospital of Capital Medical University from February 2023 to August 2023 were included in this retrospective study.</p><p><strong>Results: </strong>In total, 12 patients with DLBP were included. The preoperative visual analog scale (VAS) score was 7.00(6.00, 7.75), while the postoperative VAS score at 1 day, 1 month, and 3 months was 1.00 (1.00, 1.00). This represented a statistically significant improvement compared to the preoperative period (all <i>p</i> = 0.002). The preoperative Pittsburgh Sleep Quality Index (PSQI) score was 14.42 ± 1.83, and the postoperative PSQI scores at 1 month and 3 months were 4.75 ± 1.06 and 2.17 ± 1.11, respectively (all <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>RFA of the SVN provides satisfactory short-term clinical results in patients with DLBP following lumbar interbody fusion. It appears to be an effective treatment for patients with DLBP who have poor outcomes after open lumbar spine surgery.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1539971"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.","authors":"Li Jiang, Dheeraj Gandhi, Andrew Furman, Howard M Eisenberg, Paul Fishman, Elias R Melhem, Rao P Gullapalli, Jiachen Zhuo","doi":"10.3389/fneur.2025.1526501","DOIUrl":"https://doi.org/10.3389/fneur.2025.1526501","url":null,"abstract":"<p><strong>Objectives: </strong>To advance the mechanistic understanding of changes occurring to brain connectivity after successful MR-guided Focused Ultrasound ventral intermediate nucleus (VIM) thalamotomy for essential tremor (ET).</p><p><strong>Methods: </strong>This retrospective study included fifteen right-handed ET patients, who underwent successful unilateral VIM ablation and experienced improved hand tremor on their dominant hand. Resting-state fMRI scans were conducted both before and 1-year post-treatment for all participants. A seed-based whole brain resting-state functional connectivity (FC) analysis was performed, centering on tremor-related regions within the cerebello-thalamo-cortical (CTC) network, including the left and right ventral intermediate nucleus (VIM), primary motor cortex (M1H), and dentate nucleus (DN). The study examined both the changes in FC and their correlation with clinical outcomes evaluated using the Clinical Rating Scale for Tremor (CRST) at the 1-year post-treatment.</p><p><strong>Results: </strong>ET patients demonstrated significant tremor improvement at the treated hand, which persisted throughout the 1-year study period. Compared with the baseline, FC of both left VIM and right VIM decreased in precentral gyrus and postcentral gyrus; FC of left M1 hand area increased in premotor cortex and supplemental motor area (SMA); and FC of left DN also increased in premotor cortex, SMA, M1, and anterior cingulate cortex (ACC). Association analysis between changes in left VIM functional connectivity and contralateral hand tremor scores revealed a significant negative correlation in the bilateral precentral gyrus, superior parietal lobule, precuneus, occipital cortex, and middle prefrontal cortex. Conversely, a significant positive correlation was observed in the frontal orbital cortex, right insular cortex, temporal pole, hippocampus, left lingual gyrus, right cerebellar lobules IV/V, left cerebellar lobule VI, and vermis IV/V.</p><p><strong>Conclusion: </strong>Our findings of altered functional connectivity within the cerebello-thalamo-cortical network, encompassing regions involved in motor, sensory, attention, visual, and visuospatial functions, and its association with hand tremor improvement suggest that targeting functional connectivity abnormalities may be a potential approach for alleviating tremor symptoms in ET patients.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1526501"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}