Frontiers in Neurology最新文献

{"title":"Conventional and novel hypoxemia-related indices for obstructive sleep apnea severity and incident hypertension: a prospective cohort study.","authors":"Lixia Wang, Xinjie Hui, Rong Huang, Yi Xiao","doi":"10.3389/fneur.2026.1973505","DOIUrl":"10.3389/fneur.2026.1973505","url":null,"abstract":"<p><strong>Background and objective: </strong>Obstructive sleep apnea (OSA) is associated with hypertension (HTN), but the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) may not fully characterize nocturnal hypoxemia relevant to HTN development. We evaluated the associations of the sleep breathing impairment index (SBII) and hypoxic burden (HB) with incident HTN and compared their discriminative performance with AHI and ODI.</p><p><strong>Methods: </strong>This prospective study included 601 participants with OSA (AHI ≥ 15 events/h) from Sleep Heart Health Study who were free of HTN at baseline. SBII, HB, AHI and ODI were analyzed both in quartiles and as continuous variables. Multivariable logistic regression and restricted cubic spline analyses were used to evaluate their associations with incident HTN. Discrimination performance was assessed by comparing a clinical base model with models that separately incorporating each quartile-categorized index.</p><p><strong>Results: </strong>During a median follow-up of approximately 5 years, 194 (32.3%) participants developed HTN. In the primary fully adjusted model, the highest quartiles of SBII (OR, 1.71; 95% CI, 1.02-2.90; <i>p</i> = 0.044) and HB (OR, 1.69; 95% CI, 1.02-2.79; <i>p</i> = 0.041) were associated with higher odds of incident HTN. In the T90-adjusted sensitivity model, both associations were significant, whereas AHI and ODI quartiles remained nonsignificant. The clinical base model had a C-statistic of 0.614; adding SBII or HB, did not significantly improve discrimination.</p><p><strong>Conclusion: </strong>Exploratory quartile-based analyses suggested that the highest quartiles of SBII and HB were associated with higher odds of incident HTN among participants with OSA, whereas AHI and ODI were not. These findings indicate that marked elevation in SBII and HB may provide a more comprehensive characterization of OSA-related nocturnal hypoxemia relevant to incident HTN. However, the nonsignificant continuous and overall spline analyses and the limited incremental discrimination warrant cautious interpretation and further validation.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1973505"},"PeriodicalIF":3.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional transcutaneous electrical nerve stimulation shows no short-term safety signal in painful cervical dystonia: a pilot prospective study.","authors":"Jason Becker, Jonathan Epstein, Solène Frismand, Salomé Puisieux","doi":"10.3389/fneur.2026.1909821","DOIUrl":"10.3389/fneur.2026.1909821","url":null,"abstract":"<p><strong>Background and purpose: </strong>Cervical dystonia (CD) is frequently associated with chronic cervical pain refractory to botulinum neurotoxin (BoNT) therapy. Transcutaneous electrical nerve stimulation (TENS), a non-invasive neuromodulation technique with established analgesic properties, has not been formally evaluated in CD. This pilot study assessed the safety and tolerability of conventional TENS in painful CD, with exploratory evaluation of pain outcomes.</p><p><strong>Methods: </strong>This prospective, observational, single-arm study (NCT04949594) included patients with painful CD treated or not with BoNT. The primary outcome was the mean change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score between peak BoNT efficacy time points before (T1) and after TENS introduction (T2), assessed against an exploratory -8-point safety threshold. Secondary outcomes included TWSTRS subscores and Pain Numeric Rating Scale (PNRS).</p><p><strong>Results: </strong>Fifteen patients completed the study. The mean T1-T2 TWSTRS total score change was +3.42 (95% CI - 0.86 to 7.69), remaining above the exploratory -8-point safety threshold, with no group-level signal of clinically meaningful worsening. At the individual level, only three patients (20%) showed a worsening, two of whom (13.3%) exceeded the -8-point threshold (-11.5 and -9.5 points). TWSTRS subscores and PNRS showed no statistically significant changes after correction for multiple comparisons. Adverse events were mild and transient, and 80% of patients reported satisfaction and continued TENS use at follow-up.</p><p><strong>Conclusion: </strong>Conventional TENS showed no short-term safety signal and was well tolerated in painful CD, supporting its feasibility as an adjunctive neuromodulation approach in this small, uncontrolled pilot cohort, pending confirmation in randomized sham-controlled trials.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1909821"},"PeriodicalIF":3.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous hyperkinetic movement disorders phenotyping: a cross-cohort pediatric transfer study using routine videos, markerless pose estimation and a tabular foundation model.","authors":"Laura Cif, Diane Demailly, Zohra Souei, Muhammad Mushhood Ur Rehman, Juan Dario Ortigoza-Escobar, Mayté Castro-Jiménez, Cécile A Hubsch, Sophie Huby, Morgan Dornadic, Gun-Marie Hariz, Eduardo M Moraud, Jocelyne Bloch, Gabriella A Horvàth, Xavier Vasques","doi":"10.3389/fneur.2026.1904458","DOIUrl":"10.3389/fneur.2026.1904458","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Accurate recognition of movement disorders (MDs) phenomenology remains a demanding task in pediatric practice, compounded by mixed and evolving motor presentations, inter-examiner expertise variability, and the scarcity of structured digital tools validated across age groups. A child with combined MDs may receive different phenomenological diagnoses from different examiners, with direct consequences for etiological guidance, treatment planning, neuromodulation candidacy, and longitudinal monitoring. Video-based examination is already central to expert practice, but its systematic analysis remains frequently inaccessible because of limited human resources.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To develop and externally test a video-based framework for simultaneous detection of hyperkinetic MDs phenomenologies: dystonia, tremor, myoclonus, chorea, athetosis, ballismus, stereotypies, and tics using routine clinical recordings, with external, cross-cohort transfer from adult to pediatric populations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this proof-of-concept study, the framework combines markerless pose estimation, kinematic descriptors, and a pretrained foundation model. A shared predictive backbone was developed on 21 adults with confirmed hyperkinetic MDs and 4 healthy controls. External validation was performed on an independent cohort: a real-world pediatric sample (&lt;i&gt;n&lt;/i&gt; = 12, monogenic combined MDs). For the external dataset, the backbone was deployed without retraining; lightweight calibration adjusted only the final subject-level decision step using a clinician-labeled small representative subset of patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After local calibration of the decision layer on the clinician-selected subset, performance improved on the held-out pediatric patients (&lt;i&gt;n&lt;/i&gt; = 7): Hamming accuracy rose from 0.804 to 0.839 and the Jaccard index from 0.548 to 0.633 (true positives 8 to 13, false negatives 9 to 4, false positives 2 to 5, across 56 patient-phenomenology decisions). Given the small held-out sample, these estimates should be regarded as exploratory. This calibrated performance was preserved, and the Jaccard index further improved, when the evaluation was restricted to the phenomenologies with more definite clinician agreement (Hamming accuracy 0.9, Jaccard index 0.786), indicating that the gains did not rest on the least-reliable labels.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;A two-stage strategy, a reusable predictive backbone combined with lightweight, site-specific adaptation, may offer a practical and scalable route to routine-video-based digital phenotyping of MDs across age groups. A shared backbone trained on standardized adult recordings transferred phenotyping signal to an independent, real-world pediatric cohort without retraining. Local calibration of the decision layer improved performance in this small exploratory cohort, while clinical-grade reliability across the full phenotypic spe","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1904458"},"PeriodicalIF":3.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capillary stalling after traumatic brain injury: an emerging microcirculatory contributor to secondary brain injury.","authors":"Xiaolong Lei, Yan Yang, Xiaokun Yang, Kai Tao","doi":"10.3389/fneur.2026.1971528","DOIUrl":"https://doi.org/10.3389/fneur.2026.1971528","url":null,"abstract":"<p><p>Secondary brain injury after traumatic brain injury (TBI) has traditionally been understood and managed through the lens of intracranial pressure, cerebral perfusion pressure, and global cerebral blood flow. Yet a substantial proportion of patients continue to exhibit persistent tissue hypoxia and metabolic crisis even when these macrocirculatory parameters appear adequately controlled. Capillary stalling-the transient or sustained interruption of red blood cell transit within individual or focal capillary networks-may represent an under-recognized microcirculatory disorder that conventional macrovascular monitoring cannot capture. This review synthesizes evidence supporting capillary stalling as a potentially distinct and reversible component of post-traumatic microvascular failure. We examine candidate mechanisms of capillary flow interruption after TBI, including endothelial injury and glycocalyx disruption, leukocyte plugging, pericyte contraction, platelet activation and microthrombosis, red blood cell dysfunction, and edema-associated extravascular compression. These mechanisms can generate marked capillary flow heterogeneity, impair oxygen extraction, and contribute to metabolic crisis, neuroinflammation, and secondary neuronal injury. We further discuss why conventional bedside monitoring-including intracranial pressure, cerebral perfusion pressure, global cerebral blood flow, brain tissue oxygenation, and microdialysis-may fail to detect capillary-level flow abnormalities, and we review established and emerging detection strategies from experimental two-photon microscopy to clinical surrogates. Finally, we evaluate potential microcirculation-targeted therapeutic avenues. Direct evidence of capillary stalling in human TBI remains limited; accordingly, it should currently be viewed as a biologically plausible and testable contributor to secondary brain injury rather than an established dominant driver.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1971528"},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13681361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central nervous system, cranial, and cerebrovascular conditions beyond the Kimonis criteria in patients with Gorlin syndrome: a retrospective cohort study.","authors":"Yukie Arahata, Katsunori Fujii, Daisuke Sawada, Tomoko Uchida, Takeshi Yaga, Tadashi Shiohama","doi":"10.3389/fneur.2026.1935340","DOIUrl":"10.3389/fneur.2026.1935340","url":null,"abstract":"<p><strong>Background: </strong>Gorlin syndrome is a multisystem developmental and cancer-predisposing disorder commonly caused by germline <i>PTCH1</i> variants. The Kimonis clinical criteria capture the canonical phenotype; however, central nervous system (CNS), cranial, and cerebrovascular conditions documented beyond these criteria remain poorly defined.</p><p><strong>Methods: </strong>We conducted a retrospective descriptive cohort study of 32 patients who fulfilled the Kimonis clinical criteria and received care at either or both hospitals in Japan. Clinical information through March 31, 2026, including sufficiently documented care elsewhere, was reviewed. The exploratory primary descriptive outcome was defined as the presence of at least one documented condition in three categories: structural CNS or cranial conditions, cerebrovascular disorders, or CNS neoplasms other than medulloblastoma. The three categories were considered separately.</p><p><strong>Results: </strong>A <i>PTCH1</i> sequence variant or whole-gene deletion was documented in 24 of 32 patients. Eight patients had 10 documented findings representing eight conditions, including hydrocephalus, Chiari malformation, syringomyelia, moyamoya disease, and cerebral infarction. These findings were identified during routine longitudinal clinical care rather than systematic neuroimaging screening and therefore should not be interpreted as a prevalence estimate. Four patients underwent neurosurgical or cerebrovascular interventions.</p><p><strong>Conclusion: </strong>Clinically relevant CNS, cranial, and cerebrovascular conditions documented beyond the Kimonis criteria may warrant consideration when new neurological, respiratory, or craniocervical symptoms arise. Awareness of these conditions may inform symptom-directed differential diagnosis and the selection of imaging modalities and anatomical coverage. These exploratory findings do not establish a unified neurological phenotype or causal relationship with Gorlin syndrome and do not support universal neuroimaging surveillance in asymptomatic patients.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1935340"},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mirror therapy for upper limb motor recovery after stroke: a meta-analysis.","authors":"Yi Man, XiaoPei Liu, Xinyi Feng","doi":"10.3389/fneur.2026.1892502","DOIUrl":"10.3389/fneur.2026.1892502","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the rehabilitation effect of mirror therapy (MT) on upper limb motor function in stroke patients, thereby providing evidence-based support for clinical rehabilitation decision-making.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) investigating MT for upper limb dysfunction after stroke were retrieved from the PubMed, Web of Science, Cochrane Library, and EMBASE databases. The risk of bias in the included studies was assessed using the Cochrane Risk of Bias tool 2.0 (RoB 2.0). A meta-analysis was performed, and the grade of evidence was determined using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.</p><p><strong>Results: </strong>A total of 21 RCTs were ultimately included. The meta-analysis showed that MT significantly improved the total score of the Fugl-Meyer Assessment Upper Extremity (FMA-UE) in stroke patients (Mean Difference [MD] = 5.45, 95% Confidence Interval [95% CI]: 3.50-7.41, <i>p</i> < 0.001). Hand function showed a statistically significant but clinically modest improvement (MD = 1.16, 95% CI: 0.03-2.29, <i>p</i> = 0.04); however, sensitivity analysis indicated that this statistical significance was not robust and depended on a small number of high-weight studies. A positive trend toward improvement was observed for shoulder-elbow-forearm function (MD = 1.79, 95% CI: -0.02 to 3.60, <i>p =</i> 0.05). However, no statistically significant improvement was found for wrist joint function (MD = 0.65, 95% CI: -0.17 to 1.47, <i>p =</i> 0.12). Heterogeneity was low across outcomes. No clear evidence of publication bias was detected; however, the number of studies was small for some outcomes, limiting the power of funnel plots and Egger's test. The overall quality of evidence was moderate to low.</p><p><strong>Conclusion: </strong>MT may improve global upper limb motor function in stroke patients, with a more modest and less robust effect on hand function. The statistical significance of the hand-function finding depended on a small number of high-weight studies, and the evidence for hand function is of low quality; the overall evidence is low-to-moderate. Therefore, these findings, especially those for hand function, should be interpreted cautiously, and further high-quality studies are warranted.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420261395137, PROSPERO registration number: CRD420261395137.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1892502"},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture for sleep disorders in amnestic mild cognitive impairment: a randomized controlled trial with fMRI.","authors":"Di Qiu, Ruiyao Li, Jikang Yang, Liyao Ding, Jiayong Deng, Yongfeng Liu, Jinhuan Zhang","doi":"10.3389/fneur.2026.1913478","DOIUrl":"10.3389/fneur.2026.1913478","url":null,"abstract":"<p><strong>Objective: </strong>To access the efficacy of acupuncture in improving sleep disorders in patients with amnestic Mild Cognitive Impairment (aMCI) and to investigate its mechanisms.</p><p><strong>Methods: </strong>Thirty aMCI patients with sleep disorders and fifteen healthy controls (HC) were enrolled. Patients were randomly assigned to verum acupuncture group (VA) or sham acupuncture group (SA) for a 12-week treatment. Assessments included the Montreal Cognitive Assessment (MoCA), Pittsburgh Sleep Quality Index (PSQI), and resting-state Functional Magnetic Resonance Imaging (fMRI).</p><p><strong>Results: </strong>At baseline, patients with aMCI exhibited aberrant brain activity in temporal, frontal, parietal, and cerebellar regions compared with HCs. After treatment, the VA group, but not the SA group, showed significant improvements in both MoCA and PSQI scores. Rs-fMRI analyses revealed significant VA-related changes in the amplitude of low-frequency fluctuation (ALFF) in the left calcarine sulcus and regional homogeneity (ReHo) in the cerebellar vermis. Changes in these imaging indicators were significantly correlated with changes in MoCA scores but not with changes in PSQI scores. Moreover, changes in MoCA scores were negatively correlated with changes in PSQI scores in the VA group (<i>r</i> = -0.536, <i>p</i> = 0.039).</p><p><strong>Conclusion: </strong>Acupuncture could effectively improve sleep and cognitive function in aMCI patients. The treatment-related alterations in brain function may be associated with changes in the dermatome layer and the brain-cerebellar cortex circuitry.</p><p><strong>Clinical trial registration: </strong>https://itmctr.ccebtcm.org.cn/mgt/search, Identifier ITMCTR2026000708.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1913478"},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurogenic thoracic outlet syndrome: a review of diagnostic and therapeutic strategies.","authors":"Guang-Yao Li, Ming-Qiang Xue, Jing-Wei Wang, Ke Sha","doi":"10.3389/fneur.2026.1932666","DOIUrl":"https://doi.org/10.3389/fneur.2026.1932666","url":null,"abstract":"<p><p>The diagnosis and treatment of neurogenic thoracic outlet syndrome (nTOS) remain challenging. Although consensus-based clinical frameworks exist, they lack robust externa validation. This study conducts a review of nTOS publications in the PubMed, Embase, and Web of Science databases, with a search cutoff date of December 2025. Current evidence suggests that the incidence of nTOS may be underestimated. Diagnosis should be based on a comprehensive evaluation, including medical history, systematic physical examination, ancillary examinations, diagnostic muscle block, and exclusion of other possible diseases. Treatment should be carried out in a phased manner. For mild cases, nonsurgical treatment is preferred. For patients who experience progressive neurological dysfunction, muscle atrophy, or failure of conservative treatment, timely surgery should be considered. Surgical decompression mainly involves the supraclavicular or axillary approaches. Surgical techniques include first rib resection, rib-sparing scalenectomy, pectoralis minor release, cervical rib resection. However, the optimal treatment remains controversial due to the limited availability of high-quality evidence. Future research should focus on elucidating the pathophysiology of nTOS, improving diagnostic accuracy through technological innovation, and optimizing treatment protocols through prospective multicenter studies.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1932666"},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13681301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association of infarct volume with early neurological deterioration in ischemic stroke patients undergoing endovascular treatment.","authors":"Jianqiang Hu, Jiawei Zhang, Chao Cai, Kefangyuan Zheng, Mingqing Cheng, Xin Miao, Jiarui Bao, Donghua Xian, Yalan Fang, Jin Zhang","doi":"10.3389/fneur.2026.2008304","DOIUrl":"https://doi.org/10.3389/fneur.2026.2008304","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fneur.2026.1755496.].</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"2008304"},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13681829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of FcRn inhibition on overlapping autoimmune comorbidity in AChR-seropositive generalized myasthenia gravis.","authors":"Vincenzo Di Stefano, Nicasio Rini, Sofia Campo, Flora D'Amico, Aurora Meli, Simona Maccora, Filippo Brighina, Liliana Bevilacqua, Paolo Barone, Alba Rosa Pati, Mariangela Ferrara, Augusto Maria Rini, Claudia Vinciguerra","doi":"10.3389/fneur.2026.1919993","DOIUrl":"https://doi.org/10.3389/fneur.2026.1919993","url":null,"abstract":"<p><strong>Introduction: </strong>Generalized Myasthenia gravis (gMG) is a rare autoimmune disorder of the neuromuscular junction caused by IgG autoantibodies against antigens in the postsynaptic cleft. This study aimed to assess the real-world effectiveness and safety of Efgartigimod (EFG) in AChR-positive gMG with overlapping autoimmune comorbidity.</p><p><strong>Methods: </strong>EFG was administered as 4 consecutive weekly infusions or injections. Myasthenia Gravis Activity of Daily Living (MG-ADL) and Myasthenia Gravis quantitative (QMG) scales were administered at baseline and after 4 weeks. Clinical data on autoimmune comorbidities and prednisone use were collected.</p><p><strong>Results: </strong>35 patients (20 women, mean age 53.6 years) received EFG, with a significant and clinical improvement in both MG-ADL and QMG scores. MG-ADL responder rate (MG-ADL reduction≥2) was 79%, while 68% on QMG (QMG reduction≥3); Minimal symptoms expression was reached in 4 patients, with a mean reduction in daily prednisone dose of 8 mg. Overlapping autoimmune comorbidity was reported in 12 gMG patients (34%). gMG patients with Stiff-Person syndrome, type 1 Diabetes and Lambert-Eaton myasthenic syndrome benefited more from EFG with a higher reduction on MG-ADL.</p><p><strong>Conclusion: </strong>Overlapping autoimmune comorbidity is not rare. EFG demonstrated a meaningful clinical benefit in patients with AChR-positive gMG with overlapping IgG-mediated disorders.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"17 ","pages":"1919993"},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}