Fungal Biology Reviews最新文献_第4页

Utilization of Raman spectroscopy for identification and characterization of fungal pathogens 利用拉曼光谱鉴定和描述真菌病原体

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-10-10 DOI: 10.1016/j.fbr.2023.100339

Ruchira Udupa , Prakash Peralam Yegneswaran , Jijo Lukose , Santhosh Chidangil

{"title":"Utilization of Raman spectroscopy for identification and characterization of fungal pathogens","authors":"Ruchira Udupa , Prakash Peralam Yegneswaran , Jijo Lukose , Santhosh Chidangil","doi":"10.1016/j.fbr.2023.100339","DOIUrl":"10.1016/j.fbr.2023.100339","url":null,"abstract":"<div><p>Rapid and accurate identification of pathogens causing infections is one of the biggest challenges of medicine. Timely identification and characterization of fungal pathogens is essential for choosing a suitable tailored antifungal treatment and proper management of patients. This, in turn, leads to the shortening of hospital stays, reducing costs and time to adequate treatment, increasing the well-being of patients, limiting the spread of antifungal resistance, and helps to save the lives of many patients. Raman spectra allow the assessment of the overall molecular constitution of biological samples, based on specific signals from proteins, nucleic acids, lipids, carbohydrates, and inorganic crystals. It has been found to be a valuable tool for the identification of microorganisms, characterization of virulence factors, and their ability to form biofilms. The most used method in current diagnostic laboratories for fungal identification is fungal culture which can take four weeks or longer to maximize the recovery of slowly growing fungi. This needs the development of new methods to detect and identify these pathogens directly from clinical samples.</p><p>We aim to offer an evidence-based review of the Raman spectroscopy technique, its strengths, and limitations with respect to its use in the field of medical mycology to help in the early detection of fungal pathogens. Raman spectroscopy can be used not only for identification but, also for the biochemical analysis of the fungal pathogen. It is a precise, convenient, and low-cost method for fungal detection. Analysis of various cell organelles present in the fungal cell can help us understand the cell dynamics and enable us to study the reaction of those cells under different environmental stresses. It can also help us to further study mechanisms of antifungal resistance.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"47 ","pages":"Article 100339"},"PeriodicalIF":6.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1749461323000453/pdfft?md5=069b7c7ebfeb9eb15a83272f35674946&pid=1-s2.0-S1749461323000453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135655810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional requirements of the human pathogenic fungus, Trichophyton rubrum, and nutritional immunity of the human skin as barrier against colonization 人类病原真菌红毛癣菌的营养需求，以及人体皮肤作为抗定植屏障的营养免疫

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-09-01 DOI: 10.1016/j.fbr.2023.100330

Oliver Blechert , Shuzhen Xiong , Jingjing Chen , Alexandra C. Brand , Ping Zhan

{"title":"Nutritional requirements of the human pathogenic fungus, Trichophyton rubrum, and nutritional immunity of the human skin as barrier against colonization","authors":"Oliver Blechert , Shuzhen Xiong , Jingjing Chen , Alexandra C. Brand , Ping Zhan","doi":"10.1016/j.fbr.2023.100330","DOIUrl":"10.1016/j.fbr.2023.100330","url":null,"abstract":"<div><p><span><em>Trichophyton rubrum</em></span><span> is a pathogenic fungus infecting human skin, hairs and nails. These substrates are colonized only by very few fungal species. In this review, we summarise the nutritional requirements of fungal species, with a focus on </span><em>T. rubrum</em><span><span>, and compare them with nutrients available in the keratinized tissues. The outer layers of the human skin are low in most nutrients required for fungal growth, the basis of nutritional immunity. Carbohydrate availability is low and protein, in the form of </span>keratin, is used for energy and carbon by the fungus. In addition to the nitrogen derived from keratin, the skin is rich in phosphorus, sulfur, potassium and chloride. The concentration of trace elements is very low, especially in the outermost layer of the skin, and magnesium, iron and zinc are likely the most relevant limiting elements for </span><em>T. rubrum</em>. We point to the evolutionary adaption of the fungus to the human skin. <em>T. rubrum</em> has a sophisticated system for the digestion and utilization of extracellular protein and a relative low demand for micronutrients.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"45 ","pages":"Article 100330"},"PeriodicalIF":6.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48656407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements, deficiencies, and future necessities of studying Saprolegniales: A semi-quantitative review of 1073 published papers Saprolegniales研究的进展、不足和未来的必要性：1073篇已发表论文的半定量综述

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-05-12 DOI: 10.1016/j.fbr.2023.100319

Hossein Masigol , Pieter van West , Seyedeh Roksana Taheri , Juan-Miguel Fregeneda-Grandes , Lucian Pârvulescu , Debbie McLaggan , Tim Tobias Bliss , Reza Mostowfizadeh-Ghalamfarsa , Mohammad Javad Pourmoghaddam , Hans-Peter Grossart

{"title":"Advancements, deficiencies, and future necessities of studying Saprolegniales: A semi-quantitative review of 1073 published papers","authors":"Hossein Masigol , Pieter van West , Seyedeh Roksana Taheri , Juan-Miguel Fregeneda-Grandes , Lucian Pârvulescu , Debbie McLaggan , Tim Tobias Bliss , Reza Mostowfizadeh-Ghalamfarsa , Mohammad Javad Pourmoghaddam , Hans-Peter Grossart","doi":"10.1016/j.fbr.2023.100319","DOIUrl":"10.1016/j.fbr.2023.100319","url":null,"abstract":"<div><p>Research on the order <em>Saprolegniales</em> (<em>Oomycota</em>) has been an ongoing quest for more than a century. The best studied genera are <em>Saprolegnia</em> and <em>Aphanomyces</em>, known for their pathogenicity on freshwater animals. In this study, we reviewed 1073 papers and 2803 ITS sequences of <em>Saprolegniales</em> to investigate their taxonomy, diversity and potential roles in mainly freshwater ecosytems. We found that, in general, our knowledge on diversity and ecology of <em>Saprolegniales</em> is limited. Neither classic taxonomy nor available molecular techniques have been sufficient to delineate genera and species and show their relative distribution in freshwater-associated habitats. Also, we currently lack a comprehensive understanding of their involvement in carbon turnover and food web dynamics. Finally, due to lack of using high-throughput sequencing techniques, it is not clear how and to what extent communities of <em>Saprolegniales</em> might differ in freshwater econiches. Therefore, we provide a historical perspective on the establishment of <em>Saprolegniales</em>, explain improvements, highlight deficiencies, and finally propose new research avenues for more systematic studies. We conclude that challenges in studying <em>Saprolegniales</em> can be removed by increasing the practicality of classic taxonomy and applying available molecular toolboxes (multi-gene phylogeny and high-throughput sequencing). Additionally, inclusion of <em>Saprolegniales</em> in freshwater carbon cycling should be addressed for their better ecological resolution.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"46 ","pages":"Article 100319"},"PeriodicalIF":6.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44557929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal calcineurin complex as an antifungal target: From past to present to future 真菌钙调磷酸酶复合体作为抗真菌靶点:从过去到现在再到未来

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.fbr.2022.10.003

Xingyue Li , Chi Zhang , Ling Lu

{"title":"Fungal calcineurin complex as an antifungal target: From past to present to future","authors":"Xingyue Li , Chi Zhang , Ling Lu","doi":"10.1016/j.fbr.2022.10.003","DOIUrl":"10.1016/j.fbr.2022.10.003","url":null,"abstract":"<div><p>The serine/threonine phosphatase calcineurin complex has been considered a prospective target for developing novel drugs due to its importance in fungal growth, virulence, and stress responses in pathogenic fungi. Therefore, two well-known immunosuppressants, FK506 and cyclosporine A were successfully identified to inhibit calcineurin by combining with FK506-binding protein 12 and cyclophilin A, respectively. However, these drugs are immunosuppressive and may exhibit serious side effects. There is a growing number of literatures reported on further exploring functions of the calcineurin complex as promising antifungal targets. In general, the majority of the calcineurin complex structures are conserved but some functions are species-specific. Nevertheless, there still have a lot of functional motifs in the calcineurin complex that are unexplored. Therefore, further investigation and experimentation into the calcineurin complex are strongly required. This review not only has summarized previous findings but also explored bioinformatics analysis along with structural models of the calcineurin complex for finding fungal-specific regions as potential targets, laying the groundwork for future research into new therapeutics.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"43 ","pages":"Article 100290"},"PeriodicalIF":6.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42261940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Role and genetic basis of specialised secondary metabolites in Trichoderma ecophysiology’ [Fungal Biol. Rev. 39 (2021) pp. 83–99] “木霉生态生理学中专门次级代谢产物的作用和遗传基础”的更正【真菌生物学第39版（2021）第83–99页】

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.fbr.2023.100311

Isabel Vicente , Riccardo Baroncelli , Rosa Hermosa , Enrique Monte , Giovanni Vannacci , Sabrina Sarrocco

引用次数: 0

Discoveries and identification methods of metal oxalates in lichens and their mineral associations: A review of past studies and analytical options for lichenologists 地衣中金属草酸盐的发现和鉴定方法及其矿物关联:回顾过去的研究和地衣学家的分析选择

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.fbr.2022.09.003

Viktória Krajanová

{"title":"Discoveries and identification methods of metal oxalates in lichens and their mineral associations: A review of past studies and analytical options for lichenologists","authors":"Viktória Krajanová","doi":"10.1016/j.fbr.2022.09.003","DOIUrl":"10.1016/j.fbr.2022.09.003","url":null,"abstract":"<div><p>Lichens are generally acknowledged as the main agents of the initial bioweathering of rock substrates. The most direct evidence of a chemical interaction between lichens and their mineral substrata is the production of oxalic acid, of which interaction with ions present in a close lichen environment occasionally results in the precipitation of metal oxalates. In the past, only a few studies revealed the presence of metal oxalates in lichens, and currently, almost no new discoveries are arriving. Therefore, the main goal of this review is to bring the focus back to this phenomenon. To date, only Mg oxalate dihydrate, Mn oxalate dihydrate, Cu oxalate hemihydrate, Zn oxalate dihydrate, and anhydrous Pb oxalate have been detected in lichens. The most reliable diagnostic methods of metal oxalates in lichens are powder X-ray diffraction (pXRD), infrared spectroscopy (IR), extended X-ray absorption fine structure (EXAFS) spectroscopy, and Raman spectroscopy. Prospective lichen specimens for investigations may be found in anthropogenically-polluted environment or naturally metal-rich rock substrata. This review acts as an initial guide that provides analytical options for field lichenologists, offers a few suggestions for further research on this matter, and encourages to new biomineral discoveries in the scope of mineralogy. Survival in the metal-toxic environment, ability to produce oxygen, and extremophile nature, are the reasons why lichens are good subjects for research within the context of currently expanding astrobiology sciences, as well.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"43 ","pages":"Article 100287"},"PeriodicalIF":6.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44637234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quick guide to secondary metabolites from Apiospora and Arthrinium Apiospora和Arthrinium次生代谢物的快速指南

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.fbr.2022.10.001

Marie L. Overgaard , Trine Aalborg , Emil J. Zeuner , Klaus R. Westphal , Frederik A. Lau , Vibeke S. Nielsen , Kasper B. Carstensen , Emil A. Hundebøll , Tia A. Westermann , Gustav G. Rathsach , Jens L. Sørensen , Jens C. Frisvad , Reinhard Wimmer , Teis E. Sondergaard

引用次数: 2

The molecular dialog between oomycete effectors and their plant and animal hosts 卵菌效应子与其动植物宿主之间的分子对话

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.fbr.2022.10.002

Marcia Saraiva , Magdalena E. Ściślak , Yerisf Torres Ascurra , Tatiana Martí Ferrando , Nikola Zic , Cyril Henard , Pieter van West , Franziska Trusch , Vivianne G.A.A. Vleeshouwers

{"title":"The molecular dialog between oomycete effectors and their plant and animal hosts","authors":"Marcia Saraiva , Magdalena E. Ściślak , Yerisf Torres Ascurra , Tatiana Martí Ferrando , Nikola Zic , Cyril Henard , Pieter van West , Franziska Trusch , Vivianne G.A.A. Vleeshouwers","doi":"10.1016/j.fbr.2022.10.002","DOIUrl":"10.1016/j.fbr.2022.10.002","url":null,"abstract":"<div><p>Oomycetes form a phylogenetically distinct group of eukaryotic microorganisms that include some of the most notorious pathogens of plants and animals. Through the deployment of a remarkably diverse array of effector proteins, oomycete pathogens succeed to overcome host defences and cause infection. Effectors can operate extracellularly or enter living cells where they target diverse subcellular compartments. Genome sequence information indicates that oomycetes express several hundred host-translocating effectors potentially targeting a myriad of host processes. To counteract, plants rely on a wide variety of extra- and intracellular immune receptors facilitating pattern-triggered and effector-triggered immunity, respectively. Similarly, effectors from animal pathogenic oomycetes also target host immune response pathways, which in turn causes the activation of the humoral and adaptive immune system. In this review, we compare plant and animal pathogenic oomycete effectors regarding their type, function, genetic diversity, as well as host responses.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"43 ","pages":"Article 100289"},"PeriodicalIF":6.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45505775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Heme sensing and trafficking in fungi 血红素感应和真菌贩运。

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.fbr.2022.09.002

Peng Xue , Eddy Sánchez-León , Djihane Damoo , Guanggan Hu , Won Hee Jung , James W. Kronstad

{"title":"Heme sensing and trafficking in fungi","authors":"Peng Xue , Eddy Sánchez-León , Djihane Damoo , Guanggan Hu , Won Hee Jung , James W. Kronstad","doi":"10.1016/j.fbr.2022.09.002","DOIUrl":"10.1016/j.fbr.2022.09.002","url":null,"abstract":"<div><p>Fungal pathogens cause life-threatening diseases in humans, and the increasing prevalence of these diseases emphasizes the need for new targets for therapeutic intervention. Nutrient acquisition during infection is a promising target, and recent studies highlight the contributions of endomembrane trafficking, mitochondria, and vacuoles in the sensing and acquisition of heme by fungi. These studies have been facilitated by genetically encoded biosensors and other tools to quantitate heme in subcellular compartments and to investigate the dynamics of trafficking in living cells. In particular, the applications of biosensors in fungi have been extended beyond the detection of metabolites, cofactors, pH, and redox status to include the detection of heme. Here, we focus on studies that make use of biosensors to examine mechanisms of heme uptake and degradation, with guidance from the model fungus <em>Saccharomyces cerevisiae</em> and an emphasis on the pathogenic fungi <em>Candida albicans</em> and <em>Cryptococcus neoformans</em> that threaten human health. These studies emphasize a role for endocytosis in heme uptake, and highlight membrane contact sites involving mitochondria, the endoplasmic reticulum and vacuoles as mediators of intracellular iron and heme trafficking.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"43 ","pages":"Article 100286"},"PeriodicalIF":6.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41119603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Introducing article numbering to Fungal Biology Reviews 《真菌生物学评论》文章编号介绍

IF 6 2区生物学

Fungal Biology Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.fbr.2023.100310

Mark Gannon

引用次数: 0