Lukman Iddrisu , Yongbin Li , Zhijia Fang , Lijun Sun , Zhiwei Huang
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Cadmium-induced metal imbalance and cadmium-responsive transcriptional activator Yap1 mediated regulation of metal homeostasis
The absorption of cadmium (Cd) initiates a sequence of detrimental effects or harm to organisms. The presence of Cd in Saccharomyces cerevisiae affects key metal import channels, leading to a disruption in the balance of metal ions inside the organism. S. cerevisiae has established metal homeostasis mechanisms in response to Cd stress, which regulates metal transporters located in the plasma and vacuole membranes. This review analyzes the maintenance of metal homeostasis in S. cerevisiae and its mechanism from three different perspectives: (1) the effects of Cd on metals, (2) the reaction of Yap1 with Cd, and (3) glutathione (GSH) regulates the homeostasis of Yap1 in relation to metal transporters. This helps us to understand how metal homeostasis is maintained in S. cerevisiae when exposed to Cd. The generally held belief is that the reaction to Cd poisoning is strongly linked to oxidative stress. This review will offer insights into new reaction pathways to Cd that are different from oxidative stress, specifically focusing on the Cd(GS)2 complex.
期刊介绍：
Fungal Biology Reviews is an international reviews journal, owned by the British Mycological Society. Its objective is to provide a forum for high quality review articles within fungal biology. It covers all fields of fungal biology, whether fundamental or applied, including fungal diversity, ecology, evolution, physiology and ecophysiology, biochemistry, genetics and molecular biology, cell biology, interactions (symbiosis, pathogenesis etc), environmental aspects, biotechnology and taxonomy. It considers aspects of all organisms historically or recently recognized as fungi, including lichen-fungi, microsporidia, oomycetes, slime moulds, stramenopiles, and yeasts.
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