Fungal Biology Reviews最新文献

{"title":"Combination of fluconazole with natural compounds: A promising strategy to manage resistant Candida albicans infections","authors":"Hui Li,&nbsp;Haisheng Chen,&nbsp;Jing Shi,&nbsp;Hao Jiang,&nbsp;Xiufeng Tang,&nbsp;Zhongxia Zhou,&nbsp;Qing Fan,&nbsp;Li Zhang,&nbsp;Yuguo Liu","doi":"10.1016/j.fbr.2024.100398","DOIUrl":"10.1016/j.fbr.2024.100398","url":null,"abstract":"<div><div>Patients admitted to the intensive care unit or immunocompromised patients frequently develop fungal infections. <em>Candida albicans</em> (<em>C. albicans</em>) is the pathogenic fungus responsible for most invasive fungal infections. Fluconazole (FLC) is the most widely used antifungal agent in clinical practice due to its effectiveness and low cost. However, due to its widespread use, <em>C. albicans</em> is becoming increasingly resistant to FLC. This increase in resistance poses a significant challenge for antifungal treatments. Various attempts have been made to reverse the resistance of <em>C. albicans</em> to FLC, including combinations with natural compounds with low toxicity, low cost, and high antifungal efficacy. Furthermore, various natural compounds have <em>in vitro</em> and <em>in vivo</em> synergistic effects with FLC against <em>C. albicans</em>, particularly when treating resistant isolates. This review summarises natural compounds that, when combined with FLC, exhibit synergistic effects against <em>C. albicans</em>. These combinations were identified through a comprehensive search of PubMed, Web of Science, and Embase databases until March 2023. Forty-eight natural antifungal compounds with potential clinical applications were identified. The most common mechanisms underlying their synergistic effects include inhibition of drug efflux, induction of mitochondrial dysfunction, and accumulation of reactive oxygen species (ROS). The combination of FLC with natural compounds provides potential new therapeutic options against <em>C. albicans</em> infections and offers insights into reversing resistance.</div></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"50 ","pages":"Article 100398"},"PeriodicalIF":5.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium-induced metal imbalance and cadmium-responsive transcriptional activator Yap1 mediated regulation of metal homeostasis","authors":"Lukman Iddrisu ,&nbsp;Yongbin Li ,&nbsp;Zhijia Fang ,&nbsp;Lijun Sun ,&nbsp;Zhiwei Huang","doi":"10.1016/j.fbr.2024.100384","DOIUrl":"10.1016/j.fbr.2024.100384","url":null,"abstract":"<div><p>The absorption of cadmium (Cd) initiates a sequence of detrimental effects or harm to organisms. The presence of Cd in <em>Saccharomyces cerevisiae</em> affects key metal import channels, leading to a disruption in the balance of metal ions inside the organism. <em>S. cerevisiae</em> has established metal homeostasis mechanisms in response to Cd stress, which regulates metal transporters located in the plasma and vacuole membranes. This review analyzes the maintenance of metal homeostasis in <em>S. cerevisiae</em> and its mechanism from three different perspectives: (1) the effects of Cd on metals, (2) the reaction of Yap1 with Cd, and (3) glutathione (GSH) regulates the homeostasis of Yap1 in relation to metal transporters. This helps us to understand how metal homeostasis is maintained in <em>S. cerevisiae</em> when exposed to Cd. The generally held belief is that the reaction to Cd poisoning is strongly linked to oxidative stress. This review will offer insights into new reaction pathways to Cd that are different from oxidative stress, specifically focusing on the Cd(GS)₂ complex.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"50 ","pages":"Article 100384"},"PeriodicalIF":5.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of abiotic factors influencing the production of plant cell wall-degrading enzymes in Botryosphaeriaceae","authors":"Julián D. Restrepo-Leal ,&nbsp;Florence Fontaine ,&nbsp;Caroline Rémond ,&nbsp;Olivier Fernandez ,&nbsp;Ludovic Besaury","doi":"10.1016/j.fbr.2024.100395","DOIUrl":"10.1016/j.fbr.2024.100395","url":null,"abstract":"<div><div>The <em>Botryosphaeriaceae</em> family includes many worldwide fungal pathogens of economically important woody plants. To penetrate and colonize the host, the <em>Botryosphaeriaceae</em> species utilize a diverse array of Plant Cell Wall-Degrading Enzymes (PCWDEs) that deconstruct the main plant cell wall polymers, <em>i.e.,</em> cellulose, hemicelluloses, pectins, and lignins. Although the PCWDEs play an essential role in pathogenicity, little has been done to understand the effect of environmental factors on their production in <em>Botryosphaeriaceae</em>. To explore the main factors influencing PCWDE production in <em>Botryosphaeriaceae</em> species, we performed a systematic search in literature databases, identifying all the existing studies reporting lignocellulolytic and pectinolytic enzyme activities. Sixty-two articles met the inclusion criteria and were included in a meta-analysis of the carbon and nitrogen source effects on the production of laccase, cellulase, xylanase, and polygalacturonase activities. Our results show that poorly-lignified plant cell walls rich in polysaccharides and nitrates enhance PCWDE titers in <em>Botryosphaeriaceae</em>. We also discuss the influence of other abiotic factors, such as temperature, pH, metal ions, moisture content, and surfactants. This review may be helpful for future works that aim to increase knowledge on the PCWDE regulation in the <em>Botryosphaeriaceae</em> family.</div></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"50 ","pages":"Article 100395"},"PeriodicalIF":5.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in maize production: A review on late wilt disease control strategies","authors":"Diana Matos ,&nbsp;Paulo Cardoso ,&nbsp;Salomé Almeida ,&nbsp;Etelvina Figueira","doi":"10.1016/j.fbr.2024.100396","DOIUrl":"10.1016/j.fbr.2024.100396","url":null,"abstract":"<div><div>Maize production faces many challenges such as fungal infections causing substantial crop losses, with 10–23% annual losses, despite fungicides use. Late wilt disease (LWD), caused by <em>Magnaporthiopsis maydis</em>, is one of these infections. This review shows that although extensive research has been done on identification and detection of pathogen and control methods to mitigate disease impacts, there are still some key factors poorly known, such as interaction with other pathogens and with secondary hosts, mechanisms triggering infection and influence of climate change on disease spread and severity. The method widely used to control this disease is the use of resistant varieties, which are threatened by the development of virulent fungal strains. Despite the availability of agrochemicals on the market such as azoxystrobin, their application can be expensive and increase fungicide resistance may impair their efficiency. Currently, phytopathologists are working to identify new biocontrol agents in plants and soil, however the use of these agents may not be sufficient, and their application can be challenging. The limited information on the biochemical and physiological mechanisms of infection and on plant biochemical, physiological and nutritional status during and after disease and their sensitive to environmental conditions may contribute to the lack of more effective methodologies of disease control. The application of biocontrol agents alone or in combination with conventional strategies emerges as a sustainable alternative that can efficiently control the disease.</div></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"50 ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Fungal Biology Reviews highlights novel books on mycology","authors":"Jan Dijksterhuis (Senior Editor),&nbsp;Irina S. Druzhinina (Senior Editor)","doi":"10.1016/j.fbr.2024.100400","DOIUrl":"10.1016/j.fbr.2024.100400","url":null,"abstract":"","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"50 ","pages":"Article 100400"},"PeriodicalIF":5.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichosporon asahii: Taxonomy, health hazards, and biotechnological applications","authors":"Aude Commenges ,&nbsp;Françoise Coucheney ,&nbsp;Marie-Hélène Lessard ,&nbsp;Djamel Drider ,&nbsp;Steve Labrie","doi":"10.1016/j.fbr.2024.100369","DOIUrl":"10.1016/j.fbr.2024.100369","url":null,"abstract":"<div><p>The genus <em>Trichosporon</em> includes yeasts that are naturally present within the human gastrointestinal tract, on the skin, and as part of the vaginal microbiota. This genus is an opportunistic pathogen, commonly found in fungal infections affecting immunocompromised individuals. The species <em>Trichosporon asahii (T. asahii)</em> causes the majority of trichosporonoses and is therefore widely studied, particularly in relation to its pathogenicity and its emerging resistance to antifungal drugs used to treat the disease. However, <em>T. asahii</em> also has important biotechnological applications, particularly its depolluting abilities and its bioproduction of flavor compounds (e.g., terpenes, C13-Norisoprenoids, C6 compounds, methyl hexanoate, and ethyl isovalerate) and antioxidant molecules. <em>T. asahii</em> also produces substances that inhibit certain contaminants found in dairy products, such as <em>Kocuria rhizophila, Clostridium tyrobutyricum,</em> and <em>Salmonella enterica</em>. Paradoxically, this yeast species also has some potential probiotic applications. This review aims to discuss and provide updates on the taxonomy, pathogenicity, and biotechnological relevance of <em>T. asahii</em>.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"49 ","pages":"Article 100369"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1749461324000149/pdfft?md5=9e2c10604dff8e835a96815a10bf94de&pid=1-s2.0-S1749461324000149-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141188514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trade-off between soil organic carbon sequestration and plant nutrient uptake in arbuscular mycorrhizal symbiosis","authors":"Sulaimon Basiru ,&nbsp;Mohamed Hijri","doi":"10.1016/j.fbr.2024.100381","DOIUrl":"https://doi.org/10.1016/j.fbr.2024.100381","url":null,"abstract":"<div><p>Arbuscular mycorrhizal fungi (AMF) play a pivotal role in soil organic carbon (C) dynamics. AMF can channel C obtained from plants into the soil as labile and recalcitrant materials with contrasting impacts on soil organic carbon (SOC) reserves. Labile C supply, while increasing microbial biomass, can also elevate microbial respiration, leading to enhanced organic matter turnover. Conversely, the production of recalcitrant materials, including biomass and glomalin-related soil protein (GRSP) can promote SOC sequestration directly by acting as long-term C storage, strengthening soil aggregates, and promoting the formation of mineral-bound organic carbon. The contrasting impacts of AMF products on SOC often generate controversies regarding the role of AMF communities in C capture, especially under rising atmospheric CO₂ concentrations. Emerging evidence suggests that distinct AMF phylogeny exhibit varying soil organic matter mobilization and symbiotic nutrient exchange abilities owing to their divergent life histories. However, we argue that resource use efficiency among AMF species significantly influences the phenotypic outcome of AM symbiosis, as well as their impacts on soil carbon dynamics. AMF functional traits favoring recalcitrant C substances including glomalin-related proteins and mineral-associated organic matter over labile C may positively impact SOC sequestration in the long-term. Whereas an AMF functional guild promoting plant growth through labile C (i.e., sugars) exudation may increase SOC turnover leading to lead to SOC loss. Although strong mutualist AMF may negatively impact SOC stocks, they can compensate for this trade-off by depositing fresh, newly fixed C and promoting plant photosynthesis. The ways in which this trade-off is offset can vary among different AMF species and community compositions, warranting further investigation.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"49 ","pages":"Article 100381"},"PeriodicalIF":5.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1749461324000265/pdfft?md5=eac26518a2b938f6aba8a495ea234566&pid=1-s2.0-S1749461324000265-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141583241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional insights into fungal F-box protein: From pathogenesis to sustainable economy","authors":"Surabhi Pal ,&nbsp;Ankita Shree ,&nbsp;Praveen Kumar Verma","doi":"10.1016/j.fbr.2024.100368","DOIUrl":"https://doi.org/10.1016/j.fbr.2024.100368","url":null,"abstract":"<div><p>Post-translational modifications (PTMs) alter the molecular structure and function of proteins while tightly regulating protein turnover and activity. Eukaryotes exhibit a wide range of PTMs, including phosphorylation, ubiquitination, acetylation, glycosylation, methylation, lipidation, and palmitoylation. Ubiquitination, facilitates the degradation of specific substrates through PTMs. This process heavily relies on the SCF complex (SKP1-Cullin-F-box protein) a type of E3 ubiquitin ligase, which plays a crucial role in the recruitment of target substrates for ubiquitination. Apart from substrate degradation, F-box proteins in pathogenic fungi are involved in diverse cellular processes essential for fungal growth and virulence. In this review article, we summarize the functions of various F-box proteins in pathogenic fungi, discussing their roles in cellular functions such as pathogenicity during host infection, transcription and cell cycle progression, endocytic recycling, sexual reproduction, mitochondrial connectivity, and maintenance of circadian rhythm. Furthermore, recent studies have revealed a novel function of fungal F-box proteins in biofuel production via CAZymes, highlighting their industrial significance. This comprehensive review aims to enhance our understanding of the emerging role of F-box proteins in host-pathogen interactions, and it holds broader significance for the scientific community, stimulating new discussions and future investigations in this field.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"49 ","pages":"Article 100368"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the labyrinth – Searching for mechanistic clues to explain the evolution of sequestrate Agaricales with labyrinthine internal chambers","authors":"Andy R. Nilsen ,&nbsp;Jonathan M. Plett ,&nbsp;Tom W. May ,&nbsp;Teresa Lebel ,&nbsp;Chris M. Brown ,&nbsp;David E.A. Catcheside ,&nbsp;David A. Orlovich","doi":"10.1016/j.fbr.2024.100380","DOIUrl":"https://doi.org/10.1016/j.fbr.2024.100380","url":null,"abstract":"<div><p>Fungi exhibit a wide range of sporophore morphologies. Amongst the Agaricomycetes, sporophores include mushroom, coralloid, bracket and sequestrate forms. A striking observation is the repeated independent evolution of sequestrate forms, which have arisen more than 100 times from lineages where exposed spore-bearing tissues are the ancestral condition. Here we review the evolution of a particular sequestrate morphology in Agaricales, the labyrinthine sequestrate syndrome. We draw on knowledge of genetic mechanisms involved in sporophore development of agarics (mushrooms) and suggest potential genetic changes in relation to the alterations to pileus, lamellae and stipe during development. We discuss mechanisms that could give rise to the sequestrate syndrome.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"49 ","pages":"Article 100380"},"PeriodicalIF":5.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1749461324000253/pdfft?md5=a903d152f1b010127de31caa768d5016&pid=1-s2.0-S1749461324000253-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreshadowing an exponential market: A brief story, applications, and perspectives of CRISPR/Cas system for the production of (hemi-)cellulases in filamentous fungi","authors":"Felipe Ferreira Silva ,&nbsp;Natana Gontijo Rabelo ,&nbsp;Klédna Constância Reis ,&nbsp;Cássio Siqueira Souza Cassiano ,&nbsp;Anderson Fernandes de Melo ,&nbsp;Débora de Oliveira Lopes ,&nbsp;Wagner Rodrigo de Souza ,&nbsp;Marina Quádrio R.B. Rodrigues ,&nbsp;Daniel Bonoto Gonçalves","doi":"10.1016/j.fbr.2024.100366","DOIUrl":"https://doi.org/10.1016/j.fbr.2024.100366","url":null,"abstract":"<div><p>The demand to develop protein production systems that are both economically and scientifically viable is reflected in the global scenario, where filamentous fungi, due to their interesting characteristics such as the high capacity to secrete proteins into the culture medium, growth in relatively simple substrates and robust post-translational machinery, among others, are presented as promising alternatives for the creation and establishment of these systems. Currently, these organisms produce a wide range of proteins, such as glycosidases, lipases, and proteases, for example. Scientific and technological development has increasingly allowed the evolution of molecular biology techniques that facilitate the genetic modification of organisms, thus, stimulating the establishment of new protein production systems. Amongst these techniques, it is possible to highlight the CRISPR/Cas system, a relatively simple, low-cost, and high-efficient tool for genetic modifications. Filamentous fungi, organisms widely used for protein production, have been used in a relatively low number of studies related to the production of (hemi-)cellulases using the CRISPR/Cas system as a genomic editing tool. (Hemi-)cellulases, enzymes that catalyze the breakdown of saccharides, are a class of enzymes that are highly researched and applied in several biotechnological areas in order to obtain a wide range of value-added bioproducts, such as bioethanol, for example. In this context, this review aims to illustrate the scenario of the application of the CRISPR/Cas technique for the production of (hemi-)cellulases, highlighting the main studies to date and the perspectives of a market that tends to grow exponentially in the coming years.</p></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"49 ","pages":"Article 100366"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}