Frontiers in Public Health最新文献

{"title":"Mental health of general practitioners and family medicine specialists 2 years into the COVID-19 pandemic.","authors":"Marija Zafirovska, Jelena Danilenko, Aleksandar Zafirovski, Kristien Coteur, Heidrun Lingner, Cristián Andrés Frigolett, Milena Cojić, Mustafa Kürşat Şahin, Carmen Iliana Busneag, Nicola Buono, Aleksander Stepanović, Christine Brütting, Lyubomir Kirilov Kirov, Zaim Jatić, Liljana Ramasaco, Monika Brovč, Vanja Lazić, Erjona Abazaj, Ljubin Šukriev","doi":"10.3389/fpubh.2025.1464639","DOIUrl":"10.3389/fpubh.2025.1464639","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has significantly impacted general medical practice by altering work structures and increasing teamwork while also adversely affecting the mental health of general practitioners and family medicine specialists. This study assesses depression, anxiety, and fear levels among general practitioners and family medicine specialists in Europe 2 years after the COVID-19 pandemic's onset, and it explores influencing factors.</p><p><strong>Methods: </strong>This observational cross-sectional study included participants from 13 European countries. Data was collected from May to August 2022 with an anonymous online survey incorporating validated questionnaires for depression (PHQ-9), anxiety (GAD-7), and fear of COVID-19 (FCV-19S). Data analysis involved descriptive statistics, correlation tests, and linear regression.</p><p><strong>Results: </strong>A total of 1,723 participants completed the survey. Findings indicated an overall mild to moderate levels of anxiety (GAD-7: 5.4 ± 4.76) and depression (PHQ-9: 6.33 ± 5.43), and moderate fear of COVID-19 (FCV-19: 12.84 ± 5.29). Key determinants of anxiety, fear, and depression included country, at-risk status, patient non-compliance, and mental health history. Sex influenced anxiety and fear, losing co-workers to COVID-19 influenced anxiety and depression, while losing relatives or friends influenced fear.</p><p><strong>Conclusion: </strong>Two years into the pandemic, European general practitioners and family medicine specialists showed mild to moderate levels of anxiety, depression, and fear. Country, at-risk status, mental health history, and work-related challenges significantly affected mental health. Crucial interventions are needed to support healthcare workers during pandemics, focusing on protective measures, stable work environments, and coping strategies for anxiety and depression.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1464639"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, delivery, and evaluation of the Texas Epidemic Public Health Institute pilot infection control lecture series.","authors":"Kayla E Ruch, Anabel Rodriguez, Janelle Rios, Luis Ostrosky-Zeichner, Eric L Brown","doi":"10.3389/fpubh.2025.1534560","DOIUrl":"10.3389/fpubh.2025.1534560","url":null,"abstract":"<p><strong>Introduction: </strong>The Texas Epidemic Public Health Institute (TEPHI) aims to keep Texans healthy and the economy strong by preparing for the next infectious disease outbreak. TEPHI's Small Rural Healthcare Preparedness core developed, delivered, and evaluated a pilot infection prevention and control webinar series called <i>Infection Control</i> for rural-serving health professionals and organizations based on infection prevention and control field best practices.</p><p><strong>Methods: </strong>Data from the first year of the Infection Control series was collected through attendee registration forms, attendance records, knowledge, and post-lecture evaluation surveys using Qualtrics. The data were analyzed using Qualtrics software. Lectures were free and open to the public across disciplines. The material was promoted through public health channels with promotional flyers.</p><p><strong>Results: </strong>1,105 individuals attended or viewed the Infection Control series. Despite a generally low response rate to evaluation surveys, feedback was consistently positive. Participants noted a \"high likelihood of future TEPHI infection prevention and control lecture attendance.\" The feedback informed improvements for the second year of the series.</p><p><strong>Conclusion: </strong>Attendees of the <i>Infection Control</i> series gained a deeper understanding of relevant policies, procedures, and practices. By providing essential, accessible education on infection prevention and control at no cost, healthcare systems, administrators, and providers in rural healthcare systems across Texas have acquired the necessary knowledge to establish and maintain a safe environment for patients and staff in healthcare settings.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1534560"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-infection symptoms up to 24 months after COVID-19: a matched cohort study in Berlin, Germany.","authors":"Anne Meierkord, Daniel Schulze, Maximilian Gertler, Joachim Seybold, Marcus A Mall, Tobias Kurth, Frank P Mockenhaupt, Stefanie Theuring","doi":"10.3389/fpubh.2025.1513664","DOIUrl":"10.3389/fpubh.2025.1513664","url":null,"abstract":"<p><strong>Introduction: </strong>Long-term health consequences after mild COVID-19 are not well described. Our aim was to estimate their prevalence and describe the time course of signs and symptoms for a period of up to 24 months after SARS-CoV-2 infection.</p><p><strong>Methods: </strong>We conducted a cohort study matched for age, sex, and test week among individuals who had attended the public COVID-19 test center at Charité-Universitätsmedizin Berlin, Germany. In early 2022, 576 former COVID-19 patients (>95% non-hospitalized) and 302 uninfected individuals responded to a questionnaire on retrospective monthly symptoms since the test date up to 24 months ago.</p><p><strong>Results: </strong>Symptoms compatible with long COVID were present in 42.9% (247/576) of former COVID-19 patients, compared with 21.2% (64/302) in the uninfected group. In former patients, unadjusted odds ratios (OR) were highest for disturbed taste/smell (OR 9.1 [95% CI: 4.0-21.1]), memory difficulties (OR 5.1 [95% CI: 2.9-8.9]), and shortness of breath at rest (OR 4.5 [95% CI: 1.9-10.6]). In most former COVID-19 patients, symptoms occurred in one coherent period and resolved after a median of 6.5 months, while taste/smell disturbance and neurological/cognitive symptoms showed longer times until recovery. Factors associated with long COVID-compatible symptoms included hospitalization, symptomatic COVID-19 infection, low household income and female sex.</p><p><strong>Conclusion: </strong>Post-infection symptoms in mild COVID-19 patients mostly persist for about half a year, but sometimes longer. Among uninfected individuals who never experienced COVID-19, 21.2% also reported long COVID-compatible symptoms. The current long COVID definition might require revision to prevent misclassification and over-reporting, and to improve diagnosis and prevalence estimates.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1513664"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dying to pay: end-of-life medical costs for middle-aged and older adult patients with cardiovascular and cerebrovascular diseases.","authors":"Guoheng Hu, Haining Zhao, Xiaolong Bian, Ying Li","doi":"10.3389/fpubh.2025.1548999","DOIUrl":"10.3389/fpubh.2025.1548999","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate end-of-life healthcare expenditures among middle-aged and older patients with cardiovascular and cerebrovascular diseases, with a particular focus on the existence of the \"nearing-death effect.\"</p><p><strong>Methods: </strong>Using inpatient discharge summary data from the Chinese National Medical Insurance Settlement Platform, we identified a cohort of middle-aged and older adults (aged 45 and above) diagnosed with cardiovascular and cerebrovascular diseases in Province H, China, during 2018-2019. Propensity Score Matching (PSM) was employed to examine differences in end-of-life healthcare expenditures between deceased and surviving patients. Robustness checks were performed using Multidimensional Fixed Effects (MDFE) and Difference-in-Differences Machine Learning (DDML).</p><p><strong>Results: </strong>The findings reveal a substantial increase in end-of-life healthcare expenditures among patients with cardiovascular and cerebrovascular diseases. Specifically, Total Medical Costs, Comprehensive Service Fees, Diagnosis Fees, Treatment Fees, Pharmaceutical Fees, and Nursing Care Fees rose by 34.3, 44.0, 35.7, 62.5, 49.9, and 46.8%, respectively, all statistically significant at the 1% level. These results highlight a pronounced escalation in healthcare expenditures associated with patient mortality.</p><p><strong>Conclusion: </strong>Among middle-aged and older patients with cardiovascular and cerebrovascular diseases, healthcare expenditures exhibit a distinct \"end-of-life effect,\" characterised by a sharp surge in medical spending during the final stages of life. This phenomenon underscores the intensive utilization of medical resources at the end of life, markedly differing from healthcare expenditure patterns at other stages of life.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1548999"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and transmission of HIV-1 drug resistance mutations among patients with treatment failure and newly diagnosed people in Liangshan Prefecture, China, in 2021-2023.","authors":"Rong Pei, Yulian Zhang, Chunnong Jike, Gang Yu, Ling Su, Ju Wang, Lin Xiao, Yubing Wang, Maogang Shen, Jiayi Liao, Yifei Zheng, Joris Hemelaar","doi":"10.3389/fpubh.2025.1550121","DOIUrl":"10.3389/fpubh.2025.1550121","url":null,"abstract":"<p><strong>Introduction: </strong>Despite expanded antiretroviral therapy (ART) in China, HIV transmission persists. Liangshan Prefecture is one of the areas in China most severely affected by HIV, with high levels of drug resistance. A deeper understanding of HIV-1 drug resistance can lead to improvements in current treatment policies.</p><p><strong>Methods: </strong>We conducted an analysis of HIV drug resistance mutations (DRMs) among patients with treatment failure and people newly diagnosed with HIV in Liangshan Prefecture. 8,523 blood samples were collected from people living with HIV with treatment failure and newly diagnosed individuals in all 15 counties and two cities in Liangshan Prefecture between 2021 and 2023.</p><p><strong>Results: </strong>43.0% of patients with treatment failure acquired HIV through the heterosexual route, followed by injecting drug use (38.7%), while newly diagnosed individuals mainly acquired HIV through the heterosexual route (86.7%). 95.6% of patients with treatment failure were infected with HIV-1 variant CRF07_BC and 2.7% with CRF08_BC, and newly diagnosed individuals were also main infected with HIV-1 variant CRF07_BC (90.9), followed by CRF08_BC (4.0%) and CRF01_AE (2.5%). The overall prevalence of acquired drug resistance (ADR) among patients with treatment failure was 57.4%. The overall prevalence of pre-treatment drug resistance (PDR) among newly diagnosed individuals was 23.9%. A high prevalence of ADR and PDR (especially high-level resistance) to efavirenz (48.0% vs. 11.1%) and nevirapine (49.6% vs. 11.4%) was found. The main non-nucleoside reverse transcriptase inhibitor (NNRTI)-associated ADR and PDR mutations were K103, V106, and V179. Our findings highlight age <18 years, injecting drug use, and initiation on NNRTI-based regimen as independent risk factors for HIV ADR development. We found minor variants as a risk factor for PDR, and CRF01_AE was associated with a higher risk than CRF07_BC for nucleoside reverse transcriptase inhibitor (NRTI) PDR.</p><p><strong>Discussion: </strong>Given the high levels of NNRTI ADR and PDR, future clinical treatment plans should minimize the use of NNRTI-based regimens and should instead adopt alternative ART regimens more frequently.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1550121"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the level of mixed chemicals in male urine and the prevalence of male cancers, especially prostate cancer.","authors":"Bin Zhang, Hao Sun, Bin Zhu, Mengmeng Wang, Bingli Zuo, Jiuming Dai","doi":"10.3389/fpubh.2025.1544174","DOIUrl":"10.3389/fpubh.2025.1544174","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to investigate the relationship between mixed chemicals in urine and the prevalence of cancers in men.</p><p><strong>Methods: </strong>A total of 1,068 male subjects were included in this study. Analyses were performed by several analytical methods to ensure the stability of the results: one-way analysis, WQS analysis, Qgcomp analysis, BKMR analysis, and Restricted Cubic Spline (RCS).</p><p><strong>Results: </strong>In the final adjusted model, each 1 increase in ln-transformed BPS increased the risk of developing cancerous prostate by 49% (95% CI: 1.00-2.20). The results of multiple sensitivity analyses by WQS and Qgcomp showed that the mixed chemicals was positively correlated with the prevalence of cancers and prostate cancer in men. In the final adjusted model, each quartile increase in the WQS index was associated with a 78% (OR: 1.78, 95% CI: 1.10-2.87) increase in the risk of cancers and a 148% (OR: 2.48, 95% CI: 1.07-5.71) increase in the risk of prostate cancer. Each quartile increase in the Qgcomp index was associated with a 59% (OR: 1.59, 95% CI: 1.09-2.33) increase in the risk of cancers, and a 105% (OR: 2.05, 95% CI: 1.04-4.06) increase in the risk of prostate cancer.</p><p><strong>Conclusion: </strong>In conclusion, this study showed a positive correlation between the concentrations of the three groups of mixed chemicals in urine and the prevalence of cancers in men, as well as a positive correlation with the prevalence of prostate cancer.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1544174"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Food Education Program for healthcare workers: a pilot study in a Total Worker Health© approach.","authors":"Reparata Rosa Di Prinzio, Alessia Dosi, Gabriele Arnesano, Maria Eugenia Vacca, Giuseppe Melcore, Mariarita Maimone, Maria Rosaria Vinci, Vincenzo Camisa, Annapaola Santoro, Federica De Falco, Federica De Maio, Guendalina Dalmasso, Eugenio Di Brino, Valerio Pieri, Salvatore Zaffina","doi":"10.3389/fpubh.2025.1523131","DOIUrl":"10.3389/fpubh.2025.1523131","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity has been identified as a crucial cause of non-communicable diseases, especially for healthcare workers who often take a brief lunch break with high energy and micro- and macronutrients deficient food.</p><p><strong>Methods: </strong>Our study aims to investigate the clinical and economic effectiveness of the \"Food Education Program\" (FEP) among healthcare workers having weight problems. Four questionnaires were administered before and after FEP to explore the risk of psychological injury (\"Psychological Injury Risk Indicator\"), mental and general health status (\"Goldberg's General Health Questionnaire-12\" and \"Short Form-36 health survey\") and eating behavior (\"Eating Attitudes Test\"). The Return on Investment (ROI) was calculated on the base of absenteeism reduction in the 1-year period after FEP.</p><p><strong>Results: </strong>Fifty-one participants (78.4% females, mean age: 52.04 ± 8.94) were included in the study. They were mainly nurses (56.9%). 54.9% were obese and 43.1% overweight. The success rate was 32.1%; the reduction in BMI was more evident in the overweight participants than the obese subjects. A significant reduction of waist-to-hip ratio, glycosylated hemoglobin, total and LDL cholesterol, and an increase in vitamin D was observed (<i>p</i>-value: 0.047, 0.002, <0.001, 0.001, and 0.03). Scores on general health significantly improved (<i>p</i>-value <0.001 and 0.011). A mean per capita reduction of 3.70 days was observed in 1-year period after the intervention, with a ROI of 6.97.</p><p><strong>Conclusion: </strong>Food Education Program represents a successful program to improve psychophysical wellbeing of healthcare workers through healthy nutritional plans, also having a notable positive impact on the organization, including its financial accounts.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1523131"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urban air pollution and chronic respiratory diseases in adults: insights from a cross-sectional study.","authors":"Mohammed M Alyami, Fahad H Balharith, Sunil Kumar Ravi, Ravi Shankar Reddy","doi":"10.3389/fpubh.2025.1507882","DOIUrl":"10.3389/fpubh.2025.1507882","url":null,"abstract":"<p><strong>Objectives: </strong>Air pollution poses a substantial public health risk, especially in urban environments characterized by elevated levels of pollutants such as fine particulate matter (PM2.5) and nitrogen dioxide (NO2). These pollutants negatively impact respiratory health, contributing to chronic respiratory conditions and reduced lung function. This study investigated the association between air pollution exposure and respiratory health outcomes, including the prevalence of chronic respiratory conditions and pulmonary function, in an urban population. Additionally, the study sought to identify demographic subgroups that are unprotected from the ill effects of air pollution.</p><p><strong>Methods: </strong>A cross-sectional study included a total of 1,300 adult participants recruited from outpatient pulmonary and general medicine clinics. Air pollution exposure was assessed based on residential proximity to major traffic routes and ambient levels of PM2.5 and NO2 obtained from the Riyadh air quality monitoring network. Lung function was measured using spirometry, and data on chronic respiratory conditions were collected through self-reports and medical record reviews. Multivariable logistic regression and linear regression models were used to analyze the association between air pollution exposure and respiratory outcomes, adjusting for confounders such as age, gender, smoking Status, socioeconomic Status, physical activity, and occupational exposures.</p><p><strong>Results: </strong>Higher air pollution level exposures were significantly associated with an increased prevalence of chronic respiratory conditions (adjusted OR for high exposure: 2.45, 95% CI: 1.70-3.55, <i>p</i> < 0.001) and a reduction in lung function, as indicated by declines in FEV1 and FVC (adjusted FEV1 coefficient for high exposure: -0.45, 95% CI: -0.58 to -0.32, <i>p</i> < 0.001). Subgroup analyses revealed that older adults, males, and current smokers were particularly susceptible to the adverse effects of air pollution. Sensitivity analyses confirmed the robustness of these findings across different analytical scenarios.</p><p><strong>Conclusion: </strong>The study demonstrated a clear and significant association between higher air pollution level exposures and an increased risk of chronic respiratory conditions and reduced lung function. These findings highlight the need for specific interventions to decrease air pollution exposure, particularly in vulnerable urban populations, to mitigate the burden of respiratory diseases.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1507882"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a visualized risk prediction system for sarcopenia in older adults using machine learning: a cohort study based on CHARLS.","authors":"Jinsong Du, Xinru Tao, Le Zhu, Heming Wang, Wenhao Qi, Xiaoqiang Min, Shujie Wei, Xiaoyan Zhang, Qiang Liu","doi":"10.3389/fpubh.2025.1544894","DOIUrl":"10.3389/fpubh.2025.1544894","url":null,"abstract":"<p><strong>Introduction: </strong>The older adult are at high risk of sarcopenia, making early identification and scientific intervention crucial for healthy aging.</p><p><strong>Methods: </strong>This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), including a cohort of 2,717 middle-aged and older adult participants. Ten machine learning algorithms, such as CatBoost, XGBoost, and NGBoost, were used to construct predictive models.</p><p><strong>Results: </strong>Among these algorithms, the XGBoost model performed the best, with an ROC-AUC of 0.7, and was selected as the final predictive model for sarcopenia risk. SHAP technology was used to visualize the prediction results, enhancing the interpretability of the model, and the system was built on a web platform.</p><p><strong>Discussion: </strong>The system provides the probability of sarcopenia onset within 4 years based on input variables and identifies critical influencing factors. This facilitates understanding and use by medical professionals. The system supports early identification and scientific intervention for sarcopenia in the older adult, offering significant clinical value and application potential.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1544894"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of social determinants of health and prostate cancer prevalence in the US: a cross-sectional study of NHANES data from 2003 to 2010.","authors":"Danfei Hu, Xiaodong Chen, Mingyao Li, Huacai Xiong, Xuefeng Lu, Feng Chen","doi":"10.3389/fpubh.2025.1564498","DOIUrl":"10.3389/fpubh.2025.1564498","url":null,"abstract":"<p><strong>Objective: </strong>Social determinants of health (SDoH) are increasingly recognized as key factors in addressing health inequities. This study aimed to explore the association between SDoH and risk of prostate cancer (PCa).</p><p><strong>Methods: </strong>We analyzed data from the National Health and Nutrition Examination Survey 2003-2010. PCa diagnosis was based on self-reported questionnaires, while highly-probable PCa was assessed using prostate-specific antigen levels. Multivariate logistic regression, restricted cubic spline, and subgroup analysis were performed. Three models were employed: the crude model (unadjusted), model 1 (adjusted for age and race/ethnicity), and model 2 (further adjusted for body mass index, alcohol consumption, and smoking status).</p><p><strong>Results: </strong>The median age of 5,633 participants was 54 years. A negative association was found between the SDoH score and PCa prevalence (OR = 0.868, 95% CI: 0.786-0.959, <i>p</i> = 0.006). Specifically, a family income-to-poverty ratio < 3 (OR = 0.69, 95% CI: 0.499-0.954, <i>p</i> = 0.029) and lack of healthcare access or reliance on emergency rooms (OR = 0.429, 95% CI: 0.218-0.842, <i>p</i> = 0.017) were independently associated with lower PCa prevalence. In model 2, no significant association was found between SDoH and highly probable PCa. A linear association between SDoH and PCa prevalence was observed. A consistently negative association was noted among participants aged ≥ 60 years, Non-Hispanic Black, Non-Hispanic White, and non-obese individuals.</p><p><strong>Conclusions: </strong>The negative association between SDoH and PCa prevalence is likely attributable to inadequate screening and underreporting, rather than any protective effects. Unfavorable SDoH is not a risk factor for the onset of PCa. This study underscores the importance of addressing disparities in healthcare access and improving equity in PCa screening.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1564498"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}