Frontiers in Public Health最新文献

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Economic autonomy as a determinant of physical activity behavior in Chinese older adults.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-20 eCollection Date: 2024-01-01 DOI: 10.3389/fpubh.2024.1466710
Yuanheng Liu, Xianglin Luo, Hao Xu
{"title":"Economic autonomy as a determinant of physical activity behavior in Chinese older adults.","authors":"Yuanheng Liu, Xianglin Luo, Hao Xu","doi":"10.3389/fpubh.2024.1466710","DOIUrl":"10.3389/fpubh.2024.1466710","url":null,"abstract":"<p><strong>Background: </strong>The physical activity of the old people is affected by many factors, and the economic situation is an important factor affecting the physical activity. However, the relationship between economic autonomy and physical activity patterns among older adult Chinese has not been fully studied.</p><p><strong>Objective: </strong>To investigate the association between different types of economic autonomy and physical activity patterns among Chinese older adults aged 60 and above.</p><p><strong>Methods: </strong>Cross-sectional analysis of 1,961 participants from the 2018 China Health and Retirement Longitudinal Study (CHARLS). Economic autonomy was categorized into autonomous and non-autonomous groups. Physical activity was assessed through type, frequency, duration, and purpose, using validated questionnaires.</p><p><strong>Results: </strong>Economic autonomy showed positive associations with low and moderate-intensity physical activities (<i>p</i> < 0.05). However, economically non-autonomous individuals demonstrated higher participation in high-intensity physical activities, primarily due to work-related demands (78.7%). The frequency of physical activity was significantly different among economic autonomy groups (<i>p</i> < 0.01).</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"12 ","pages":"1466710"},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radon exhalation rate and natural radioactivity in the building materials used in metropolitan Jakarta and its surrounding areas, Indonesia.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1539957
Eka Djatnika Nugraha, Oumar Bobbo Modibo, Wahyudi, Radhia Pradana, Rima Agustin Merdekawati, Kartini Megagasri, Abdussalam Topandi, Agus Nur Rachman, Rusbani Kurniawan, Evans Azka Fajrianshah, Nurahmah Hidayati, Ilma Dwi Winarni, Ilsa Rosianna, Leons Rixson, Dikdik Sidik Purnama, Heru Prasetio, Shinji Tokonami
{"title":"Radon exhalation rate and natural radioactivity in the building materials used in metropolitan Jakarta and its surrounding areas, Indonesia.","authors":"Eka Djatnika Nugraha, Oumar Bobbo Modibo, Wahyudi, Radhia Pradana, Rima Agustin Merdekawati, Kartini Megagasri, Abdussalam Topandi, Agus Nur Rachman, Rusbani Kurniawan, Evans Azka Fajrianshah, Nurahmah Hidayati, Ilma Dwi Winarni, Ilsa Rosianna, Leons Rixson, Dikdik Sidik Purnama, Heru Prasetio, Shinji Tokonami","doi":"10.3389/fpubh.2025.1539957","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1539957","url":null,"abstract":"<p><strong>Introduction: </strong>Creating a safe living environment involves using healthy and sustainable building materials. Humans are exposed to natural radionuclides, such as <sup>226</sup>Ra, <sup>232</sup>Th, and <sup>40</sup>K decay series, found in building materials that pose a radiological hazard. This study is aimed to investigate the radionuclides content of building materials used in Jakarta and its surrounding areas. The computer code RESRAD-BUILD was used to calculate the annual effective dose received by an adult living in a typical room constructed with the studied building materials.</p><p><strong>Methods: </strong>Samples such as sand, cement, bricks, and Autoclaved Aerated Concrete (AAC) were collected. The <sup>222</sup>Rn surface exhalation rate was determined using the closed chamber method using RAD7, while the activity concentration of natural radionuclide was measured using a gamma spectrometer.</p><p><strong>Results and discussion: </strong>The <sup>222</sup>Rn surface exhalation rate varies from 4 × 10<sup>-2</sup> to 1.6 × 10<sup>0</sup> mBq m<sup>-2</sup> s<sup>-1</sup> with an average of 4 × 10<sup>-1</sup> mBq m<sup>-2</sup> s<sup>-1</sup>. The average <sup>222</sup>Rn exhalation rate of the building materials studied was much lower than the global average value of 1.6 × 10<sup>1</sup> mBq m<sup>-2</sup> s<sup>-1</sup>. The average activity concentration values of <sup>232</sup>Th (21 Bq kg<sup>-1</sup>) and <sup>40</sup>K (217 Bq kg<sup>-1</sup>) in all building materials studied are lower than the global average values of 45 and 412 Bq kg<sup>-1</sup>. In comparison, the average activity concentration of <sup>226</sup>Ra (34 Bq kg<sup>-1</sup>) is similar to the global average value of 32 Bq kg<sup>-1</sup>. Furthermore, the assessed radiological hazard from the measured building material has an average activity index of 0.3, while the RESRAD-BUILD estimated total annual effective dose for a typical house constructed using a mixture of the building materials was 0.11 mSv, in which indoor <sup>222</sup>Rn alone represents 92% of the total. From the assessment results, the building materials in Jakarta and its surrounding areas do not pose significant concerns regarding radiological hazards. However, the higher contribution of <sup>222</sup>Rn suggests the need for a large-scale indoor <sup>222</sup>Rn survey in the study area.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1539957"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Working from home and health complaints: on the difference between telework and informal overtime at home.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1465617
Alexandra Mergener, Nico Stawarz, Heiko Rüger, Inga Laß
{"title":"Working from home and health complaints: on the difference between telework and informal overtime at home.","authors":"Alexandra Mergener, Nico Stawarz, Heiko Rüger, Inga Laß","doi":"10.3389/fpubh.2025.1465617","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1465617","url":null,"abstract":"<p><strong>Background: </strong>With the increase in the prevalence of working from home (WFH), understanding its impact on health has become more relevant. However, the possibility that health effects may depend on the specific WFH arrangement has largely been ignored in research.</p><p><strong>Objective: </strong>The aim of this study is to offer a differentiated view of WFH by distinguishing between informal overtime at home and telework during recognized working time when assessing its associations with mental and physical health complaints. Moreover, the extent of telework is considered. The study also differentiates the group of WFH non-users by distinguishing between voluntary non-use and employer-directed non-use.</p><p><strong>Methods: </strong>We apply OLS regression models with clustered standard errors by occupation to probability-based survey data that is representative of employees in Germany. The analytical sample was restricted to employees whose job tasks could be performed at home (<i>N</i> = 10,365).</p><p><strong>Results: </strong>Compared to employer-directed non-users, working informal overtime at home is associated with more mental health complaints, while telework is associated with fewer mental and physical health complaints. However, the beneficial association between recognized telework and mental health only applies to employees with relatively small extents of telework. At higher extents of telework, the mental health advantages disappear, while those for physical health tend to remain.</p><p><strong>Conclusion: </strong>This study suggests that a nuanced look at patterns of use and non-use of WFH is essential when gauging its impact on health.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1465617"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Worldwide research trends of pregnancy hypertension in epigenetics field.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1506992
Didi Yuan, Yangqing Huang, Hanqi Liu, Haotian Tang, Junwen Liu
{"title":"Worldwide research trends of pregnancy hypertension in epigenetics field.","authors":"Didi Yuan, Yangqing Huang, Hanqi Liu, Haotian Tang, Junwen Liu","doi":"10.3389/fpubh.2025.1506992","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1506992","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension in pregnancy (HIP) poses significant health risks for both mothers and infants. Development of HIP is influenced by genetic and environmental factors, with epigenetic modifications partially explaining underlying mechanisms. Bibliometric tools aid researchers in quickly gaining insights into field dynamics and trends.</p><p><strong>Methods: </strong>In this investigation, we conducted a search for relevant publications in the Web of Science Core Collection database using specific keywords. We employed Citespace and WOSviewer software for analysis of interconnections and co-occurrence of information across publications, countries, authors, institutions, keywords and cited literature. Ultimately, we identified 4,316 research papers on hypertension in pregnancy within the epigenetics domain (HIPE).</p><p><strong>Results: </strong>Our analysis revealed that China had the highest number of publications (<i>n</i> = 1,353, 31.35%), while the University of Melbourne was the most prolific institution (<i>n</i> = 107, 2.48%). Among author analysis, Tong S emerged as highly productive (<i>n</i> = 41, 0.95%). Preeclampsia (PE) emerged as being extensively studied among various types of HIP. High-frequency keywords associated with HIP mechanisms included oxidative stress, proliferation, apoptosis and invasion. Regarding epigenetics-related terms, DNA methylation, mRNA and ncRNA exhibited distinct heat burst periods. The number of HIPE papers demonstrated an upward trend observed through three stages of growth.</p><p><strong>Discussion: </strong>Our bibliometric-based study provides novel insights into current research progress on HIP from an epigenetic perspective, serving as a source of new ideas and inspiration for future investigations of HIP diseases.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1506992"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of myopia-related behaviors among Chinese school-aged children and associations with parental awareness of myopia control: a population-based, cross-sectional study.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1520977
Chaoying Ye, Yujie Wang, Yujia Liu, Xingxue Zhu, Jianmin Shang, Xiaomei Qu
{"title":"Comparison of myopia-related behaviors among Chinese school-aged children and associations with parental awareness of myopia control: a population-based, cross-sectional study.","authors":"Chaoying Ye, Yujie Wang, Yujia Liu, Xingxue Zhu, Jianmin Shang, Xiaomei Qu","doi":"10.3389/fpubh.2025.1520977","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1520977","url":null,"abstract":"<p><strong>Background: </strong>In China, approximately 30 and 70% of primary and middle school students, respectively, have myopia, making myopia prevention and control necessary. Eye-use behaviors are closely related to myopia, highlighting the importance of determining the behavioral compliance rates of children. Parental awareness also affects children's behaviors. Therefore, we assessed the myopia-related behaviors and parental awareness of school-aged children in different city tiers of China with different refractive statuses.</p><p><strong>Methods: </strong>A population-based, cross-sectional study was conducted on Chinese children from 110 cities aged 7-15 years. Samples were equally allocated to each subgroup of city tiers, children's age groups, and children's refractive statuses. Questionnaires were designed to investigate children's behaviors, including responses to sitting position, time of eye use (single continuous near work time and breaks in between, total near work time after school each day), eye rest (break time and style during near work and outdoor time per week), light conditions in the learning environment at home, and parents' knowledge about myopia prevention and control. Associations between parental awareness and children's behaviors were analyzed using logistic regression.</p><p><strong>Results: </strong>In total, 896 questionnaires were collected. The prevalence of children's poor behaviors related to myopia ranged from 23.44 to 84.82%, with the highest and lowest being sitting position and the use of eye-protecting lamps, respectively. Children in third-tier cities were more likely to have poor sitting position (<i>p</i> < 0.01), a non-open view in front of a desk at home (<i>p</i> = 0.02), and more near activities during break times (<i>p</i> = 0.04). After adjustment for parental myopia condition and the child's sex, poor parental awareness was mainly associated with not using an eye-protecting lamp (odds ratio [OR]: 1.95, 95% confidence interval [CI]: 1.40-2.72), poor break styles (OR: 1.60, 95% CI: 1.21-2.12), and excessive total near work time (OR: 1.45, 95% CI: 1.02-2.05).</p><p><strong>Conclusion: </strong>Myopia-related behaviors were poorly performed in children, particularly among older children and those living in third-tier cities. Eye-protecting lamps, time spent doing near work, and break style were all associated with parental awareness, suggesting that better parental awareness helps children in the long run. More targeted measures could be adopted to help improve children's behaviors.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1520977"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and associated factors with oral frailty in middle-aged and older hospitalized patients: a cross-sectional study.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1446862
Jun-Kai Dou, Huan Liu, Jiahui Min, Yang Luo, Qian Liu, Xue-Zhi Shi, Xiubin Tao, Ming Zhang
{"title":"Prevalence and associated factors with oral frailty in middle-aged and older hospitalized patients: a cross-sectional study.","authors":"Jun-Kai Dou, Huan Liu, Jiahui Min, Yang Luo, Qian Liu, Xue-Zhi Shi, Xiubin Tao, Ming Zhang","doi":"10.3389/fpubh.2025.1446862","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1446862","url":null,"abstract":"<p><strong>Background: </strong>With the development of the economy and society, people pay more and more attention to oral health. Oral frailty can limit nutritional intake and make an individual physically weak, which is detrimental to people's health. Therefore, it is urgent to identify oral frailty and their associated risk factors. In this study, we aimed to evaluate the oral frailty and its influencing factors in Chinese middle-aged and older hospitalized patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from May 2023 to February 2024 in 2 tertiary hospitals in Wuhu City, Anhui Province, China. The self-designed sociodemographic information, the Oral Frailty Index-8, the 2-item Connor-Davidson resilience scale (CD-RISC-2), the sarcopenia screening questionnaire, and the three-item short literacy survey were used in this study.</p><p><strong>Results: </strong>A total of 914 middle-aged and older adults patients were recruited. The prevalence of oral frailty was 48.7% (445/914). In the univariate analysis, oral frailty was significantly associated with age, education, place of residence, monthly income, sarcopenia, resilience, and health literacy. Correlation analysis showed that oral frailty was significantly negatively correlated with sarcopenia, resilience, and health literacy. In the binary logistic regression analysis, oral frailty was significantly associated with sarcopenia, and health literacy. Health literacy was a protective factor of oral frailty.</p><p><strong>Conclusion: </strong>This study aimed to investigate the prevalence of oral frailty and identify the associated influencing factors among middle-aged and older adults patients in Anhui Province, China. This study identified several factors influencing oral frailty in middle-aged and older adults patients. Therefore, the government and relevant departments should implement targeted interventions to improve middle-aged and older adults patients' oral frailty.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1446862"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of exercise intervention on tobacco dependence: a meta-analysis.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1538833
Jinzhi Xu, Shiyue Zhang, Zichao Chen, Zhusheng Wu
{"title":"Effects of exercise intervention on tobacco dependence: a meta-analysis.","authors":"Jinzhi Xu, Shiyue Zhang, Zichao Chen, Zhusheng Wu","doi":"10.3389/fpubh.2025.1538833","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1538833","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking poses a significant threat to global human health, making smoking cessation a controllable means of preventing mortality. Exercise, as a means of promoting a healthy lifestyle, offers substantial benefits to individuals attempting to quit smoking. However, due to variations in experimental populations and conditions, the specific effects and benefits of exercise on smoking cessation remain unclear. In this meta-analysis, we comprehensively evaluated the withdrawal effects of different intensities of exercise on tobacco-dependent individuals.</p><p><strong>Methods: </strong>Statistical analysis and graphing were performed using Stata 14 and Review Manager 5.4 software. A total of 47 literatures, encompassing 57 randomized controlled trials and involving 4,267 tobacco-dependent individuals, were included.</p><p><strong>Results: </strong>The meta-analysis results showed that long-term exercise had no significant difference or impact on the degree of tobacco dependence between the exercise and control groups. However, acute exercise was associated with increased tobacco craving (desire and intensity) and more pronounced withdrawal symptoms.</p><p><strong>Discussion: </strong>Acute aerobic exercise can significantly reduce craving and withdrawal symptoms among individuals attempting to quit smoking, demonstrating a certain role in smoking cessation. Acute aerobic exercise emerges as the most effective form of physical exercise for intervening in tobacco dependence.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/, CRD42024550014.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1538833"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender-neutral vs. gender-specific strategies in school-based HPV vaccination programs: a systematic review and meta-analysis.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1460511
Nutthaporn Chandeying, Puttichart Khantee, Sirada Puetpaiboon, Therdpong Thongseiratch
{"title":"Gender-neutral vs. gender-specific strategies in school-based HPV vaccination programs: a systematic review and meta-analysis.","authors":"Nutthaporn Chandeying, Puttichart Khantee, Sirada Puetpaiboon, Therdpong Thongseiratch","doi":"10.3389/fpubh.2025.1460511","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1460511","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review and meta-analysis evaluated whether gender-neutral (GN) or gender-specific (GS) strategies more effectively enhanced knowledge, intention, and uptake of HPV vaccination among students in educational settings.</p><p><strong>Methods: </strong>A comprehensive literature search of PubMed, Scopus, Web of Science, and Cochrane Library identified 17 randomized controlled trials encompassing 22,435 participants (14,665 females, 7,770 males). Random-effects models were used to calculate standardized mean differences (SMDs) for knowledge and intention, and risk differences for vaccination uptake.</p><p><strong>Results: </strong>GN strategies achieved higher improvements in knowledge (SMD = 0.95) and intention (SMD = 0.59) compared with GS (SMD = 0.68 for knowledge, SMD = 0.14 for intention), and displayed a greater increase in uptake (5.7% versus 2.5% in GS), although this uptake difference was not statistically significant. Heterogeneity was more pronounced for knowledge outcomes and moderate for GS uptake results.</p><p><strong>Discussion: </strong>Despite GN approaches seemingly offering more robust enhancements in HPV-related knowledge and vaccination intention, additional research with robust designs and longer follow-up is required to determine whether GN interventions definitively outperform GS strategies in achieving statistically significant increases in actual vaccination uptake.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1460511"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relevance of the real-world evidence in research, clinical, and regulatory decision making.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1512429
Valton Costa, Marcelo Graziano Custodio, Eran Gefen, Felipe Fregni
{"title":"The relevance of the real-world evidence in research, clinical, and regulatory decision making.","authors":"Valton Costa, Marcelo Graziano Custodio, Eran Gefen, Felipe Fregni","doi":"10.3389/fpubh.2025.1512429","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1512429","url":null,"abstract":"<p><p>The scientific method has been established as the optimal approach for systematically gathering and interpreting data on various human phenomena, mainly through the adoption of strict experimental methods, such as controlled randomized trials, which is relevant for clinical decision-making and research, but also weights the regulatory processes for approval of drugs and other medical products. However, a key factor in strict methods is the generalizability of findings that may be limited to specific settings and patient characteristics. This limitation can be addressed by non-experimental methods aimed at investigating populations in naturalistic routine clinical settings, which may offer a more representative reflection of the usage, effectiveness, and safety of healthcare interventions. These approaches can generate the so-called real-world data and the resulting real-world evidence. In this narrative review, we present these concepts, explore the potential applications and advantages of real-world evidence for clinical, research, and regulatory decision-making, and discuss the challenges of employing it, the solutions to improve its generation, and lastly the current level of evidence required for the integration of real-world evidence into regulatory decision-making. We concluded that the advantages of using it, when utilized in a balanced manner, overcome the challenges and, therefore, can offer a time- and cost-saving solution for researchers, the healthcare industry, regulatory agencies, policymakers, and payers towards the patient benefit. The knowledge generated by this approach provides valuable additional insights into medical interventions in real patients under realistic daily scenarios.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1512429"},"PeriodicalIF":3.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restricted economic activity due to health conditions and risk of depression: results from the Korean Longitudinal Study of Aging.
IF 3 3区 医学
Frontiers in Public Health Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fpubh.2025.1442925
Il Yun, Jae-Hyun Kim, Jong Youn Moon
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