Frontiers in Public Health最新文献

{"title":"Attitudes of polish medical students toward organ donation.","authors":"Marzena Mikla, Anna Maria Cybulska, Antonio Rios, Mariusz Panczyk, Kamila Rachubińska, Artur Kotwas, Beata Karakiewicz, Elżbieta Grochans, Daria Schneider-Matyka","doi":"10.3389/fpubh.2025.1531140","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1531140","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to analyze determinants affecting attitudes toward organ donation among medical students at medical universities in Poland.</p><p><strong>Materials and methods: </strong>The study involved 1,348 medical students. It was performed using a validated questionnaire of attitude toward organ donation and transplantation (ODT) [PCID-DTO RIOS: A questionnaire designed by the International Collaborative Organ Donation project about organ transplantation and donation].</p><p><strong>Results: </strong>It was shown that those who would not donate their family member's organs for transplantation were far more likely to believe it was not their moral duty (<i>p</i> = 0.013) and to feel no solidarity with those in need (<i>p</i> = 0.000). Those who spoke to their families believed it was their moral duty (<i>p</i> = 0.000), and believed they would do it out of solidarity with those in need (<i>p</i> = 0.000). It was found that having family conversations about donating one's organs for transplantation was statistically significantly related to being a blood donor (<i>p</i> = 0.002), fear of desecration/disfigurement of the body after death in case of organ donation (<i>p</i> = 0. 000), a belief that it may be necessary to become an organ recipient in the future (<i>p</i> = 0.000), and knowledge of loved ones' opinions about ODT (father <i>p</i> = 0.000, mother <i>p</i> = 0.000), partner (<i>p</i> = 0.000).</p><p><strong>Conclusion: </strong>1. The reluctance to donate the organs of loved ones for transplantation is accompanied by a lack of a sense of moral obligation and a lack of solidarity with those in need. Conversely, conversations among loved ones about organ donation are thought-provoking, causing a sense of moral obligation and solidarity with those in need. 2. Regardless of the stance on organ donation and family discussions on the subject, the respondents do not care what happens to the body after organ donation, but they also do not know the opinions of their loved ones about ODT. 3. Conversations with loved ones contribute to the acceptance of circumstances in which organs would be harvested for transplantation without consent.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1531140"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring challenges and coping strategies in providing care for older adults with dementia: a qualitative study conducted in China.","authors":"Yanan Cheng, Meijiazi Yang, Sha Ma","doi":"10.3389/fpubh.2025.1459517","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1459517","url":null,"abstract":"<p><strong>Background: </strong>The increasing prevalence of dementias in China has imposed a substantial burden on caregivers, posing a serious threaten to their physical and mental well-being. It is imperative to explore practical measures to alleviate the stress experienced by those caregivers of older adults with dementia.</p><p><strong>Methods: </strong>A semi-structured questionnaire was adopted for conducting interviews with the participants from December 2022 to January 2023. Subsequently, the interviews were meticulously recorded and transcribed in their entirety, followed by a rigorous analysis of the resulting data and information.</p><p><strong>Results: </strong>A total of 17 participants who provided care for older adults with dementia were interviewed across various settings including rural areas, communities, hospitals, and nursing homes in Shandong Province. These caregivers encountered challenges such as limited social interaction, significant mental strain, deteriorating physical health, financial insufficiency, and a lack of professional expertise. The current social support systems were deemed insufficient for families caring for older adults with dementia. To alleviate the burden on dementia caregivers, particularly for those with low-income status, the government needs to prioritize enhancing the coverage of the long-term healthcare system and expanding the essential medication list. Given the growing population of older adults in China and the fact that most individuals with dementia are cared for by family members, it is recommended to establish a multifaceted support system involving collaboration among government, social organizations, and volunteers within both urban and rural communities.</p><p><strong>Conclusion: </strong>The gradual expansion of coverage of long-term care insurance, the proactive inclusion of dementia treatment drugs into the essential medication list, and optimization of a diversified dementia care system ought to be a matter of significant concern.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1459517"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet usage and environmental governance satisfaction in China: environmental pollution perception as a mediator.","authors":"Xiaorui Huang","doi":"10.3389/fpubh.2025.1520675","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1520675","url":null,"abstract":"<p><strong>Background: </strong>Public perception and satisfaction with environmental governance are essential for evaluating the effectiveness of national environmental policies and advancing the United Nations Sustainable Development Goals (UN-SDGs). However, the role of Internet usage in shaping these perceptions and satisfaction levels remains underexplored. This study examines the influence of different types of Internet use on residents' satisfaction with local environmental governance, with a particular focus on the mediating role of perceived environmental pollution.</p><p><strong>Methods: </strong>Data were retrieved from 3,046 respondents who participated in the 2021 Chinese Social Survey (CSS). Ordinary least squares (OLS) regression and mediation effect models were employed to analyze the relationships between Internet use, perceived environmental pollution, and satisfaction with environmental governance.</p><p><strong>Results: </strong>Frequent Internet use for browsing news (β = 0.019, SE = 0.006) and studying (β = 0.020, SE = 0.006) is positively associated with greater satisfaction with environmental governance. However, environmental pollution perception functions as a suppressing mediator in the association of Internet use for news browsing (effect = -0.004, SE = 0.001) and studying (effect = -0.004, SE = 0.001), with environmental governance satisfaction (EGS).</p><p><strong>Conclusions: </strong>This study is the first to apply expectancy-disconfirmation theory to explore public satisfaction with environmental governance. The findings provide novel insights into the role of Internet usage in shaping perceptions of environmental management and offer practical recommendation for leveraging digital engagement to enhance EGS among the public.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1520675"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial disparities in acute care utilization among individuals with myasthenia gravis.","authors":"Cynthia Qi, Pushpa Narayanaswami, Ashley E L Anderson, Deborah Gelinas, Yuebing Li, Jeffrey T Guptill, Dakshinamoorthy Amirthaganesan, Charlotte Ward, Rupesh Panchal, Amit Goyal, Glenn Phillips","doi":"10.3389/fpubh.2025.1448803","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1448803","url":null,"abstract":"<p><strong>Objective: </strong>In myasthenia gravis (MG), evidence on the impact of social determinants of health on disparities in disease burden and healthcare resource utilization is limited. This study aimed to investigate the independent association between race/ethnicity and acute care utilization during the 2 years post-diagnosis among patients with MG.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted among adults (≥18 years) with newly diagnosed MG in the United States using Optum's de-identified Market Clarity Data from January 1, 2010, to December 31, 2019. Multivariable regression models were used to assess the association between acute care utilization and race/ethnicity, insurance, exacerbation at index, and other covariates.</p><p><strong>Results: </strong>A total of 7,058 patients met the study inclusion criteria, of whom 57% (<i>n</i> = 4,052) identified as Caucasian, 6% (<i>n</i> = 445) African American, 3% (<i>n</i> = 235) Hispanic, 1% (<i>n</i> = 94) Asian, and 32% (<i>n</i> = 2,232) with missing race/ethnicity information. Compared with patients identifying as Caucasian, those identifying as African American had 37% higher odds of having an emergency department visit in year 1, and those identifying as Hispanic had 70% increase in odds of having a hospitalization event in year 2 post-diagnosis. Among other covariates, Medicaid usage, exacerbation at index, and number of outpatient visits were significantly associated with acute care utilization.</p><p><strong>Conclusion: </strong>Racial disparities significantly impacted acute care utilization in the first 2 years post-MG diagnosis. Future studies should aim to examine specific factors that may contribute to disparities such as barriers to healthcare access, greater severity of MG symptoms, and poorly controlled disease.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1448803"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatio-temporal evolution characteristics and influencing factors of environmental welfare performance in Chinese cities.","authors":"Yipeng Zhang, Meixia Wang","doi":"10.3389/fpubh.2025.1543745","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1543745","url":null,"abstract":"<p><strong>Background: </strong>In the process of China's urbanization, issues such as air pollution, water pollution, soil pollution, and noise pollution have become increasingly prominent, severely constraining the sustainable development of cities. The resultant decline in environmental welfare performance (EWP) not only affects residents' quality of life but may also lead to public health issues, increasing healthcare costs, and subsequently impacting social stability and economic development.</p><p><strong>Methods: </strong>This paper incorporates factors closely related to environmental pollution, such as residents' health and social welfare, into the analytical framework of environmental welfare performance. Using the Hybrid-Network-DEA model, we measure the EWP of 240 cities in China, and then investigate the spatial distribution characteristics and spatio-temporal evolution patterns of EWP. Finally, empirical testing of the factors influencing EWP is conducted using spatial econometric methods.</p><p><strong>Results: </strong>The overall level of EWP in 240 Chinese cities from 2004 to 2019 is relatively low, but it generally shows a wavy upward trend. Meanwhile, notable regional disparities exist in EWP, with the highest average performance in the east, followed by the west, and the lowest in the central. The main source of regional differences in EWP lies in inter-regional disparities. The greatest internal disparities are found in the east, while the largest inter-regional disparities are between the east and the west. A pronounced positive spatial autocorrelation is observed in the EWP among Chinese cities. Economic development, opening-up, financial development, digital infrastructure, and population density significantly promote the local EWP, whereas the industrial structure and transportation structure have exerted opposite effects. Additionally, the enhancement of EWP in neighboring regions is also notably facilitated by economic development, opening-up, financial development, and digital infrastructure. Within the three major regions, the direct and indirect effects of various influencing factors exhibit significant differences.</p><p><strong>Conclusion: </strong>Based on these insights, we suggest comprehensively improving environmental welfare efficiency, narrowing regional disparities, strengthening spatial agglomeration effects, optimizing industrial structure, and strengthening financial support and digital infrastructure construction.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1543745"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of migrant workers' health capital on their returning home intentions: evidence from China.","authors":"Haitao Li, Haibo Li, Hao Xiang","doi":"10.3389/fpubh.2025.1473435","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1473435","url":null,"abstract":"<p><strong>Background: </strong>The health problems and migration problems of China's huge migrant workers are related to the implementation effect of new-type urbanization and rural revitalization strategy. A thorough examination of the effect of migrant workers' health on their returning home intentions and its mechanism is imperative.</p><p><strong>Objectives: </strong>This study aims to understand the influence of migrant workers' health capital (HC) in their returning home intentions (RHI). For this, using capital theory, this study developed an empirical model to probe the impact of Chinese migrant workers' health on their RHI and analyze the paths that this influence may follow to form the RHI of migrant workers.</p><p><strong>Methods: </strong>A theoretical model was established from the perspective of capital to study the relationship between health and migrant workers' migration. A probit model was used to probe the impact of Chinese migrant workers' HC on their RHI, and propensity score matching (PSM), replacing the explained variable (REV), and transforming the model (TM) were used for the robustness test. Stepwise coefficient test (SCT) and Sobel test (ST) were used to analyze the mediating effects of economic capital (EC) and social capital (SC) in the relationship of HC affecting RHI. Data were collected from a sample of 810 migrant workers from three provinces located in eastern, central, and western China using a survey questionnaire.</p><p><strong>Results: </strong>Migrant workers' HC had a significant and negative impact on their RHI, and mental health (MH) had a greater impact on migrant workers' RHI than physical health (PH). There is regional heterogeneity in the effect of HC on the RHI of migrant workers in China. In addition, economic capital (EC) mediated indirectly the relationship between HC and RHI, while the mediating role of social capital in the relationship between HC and RHI was not significant.</p><p><strong>Conclusion: </strong>Migrant workers' HC is an important factor affecting the formation of their RHI, in which EC plays an intermediary role. This study extends and deepens our understanding of HC and helps to understand the role of health in shaping RHI from the perspective of capital, and the finding confirms the validity of the \"salmon bias effect\" hypothesis in the Chinese context. These findings can also help local government pay more attention to returning migrant workers' HC.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1473435"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring urban-rural inequities in older adults life expectancy: a case study in Zhejiang, China for health equity.","authors":"Yongguo Chen, Xiaoting Fan, Shusheng Shen, Yong Chen, Zhiwei Pan, Zixuan Chen, Haoqiang Zhong, Menglong Li","doi":"10.3389/fpubh.2025.1439857","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1439857","url":null,"abstract":"<p><p>This study investigates the inequities in life expectancy among individuals aged 65 and above in urban and rural areas of Zhejiang Province, China, with a primary focus on promoting health equity among the older adults population. The objective is to analyze the trends and factors contributing to the urban-rural gap in life expectancy and to propose strategies for reducing this disparity. Data from the 2010 and 2020 statistical records and census data were analyzed using cohort life tables and gray correlation analysis. Results indicate an overall increase in life expectancy among the older adults, with a more pronounced improvement in rural areas, thereby narrowing the urban-rural gap from 1.53 years in 2010 to 1 year in 2020. Income inequality emerges as the primary factor influencing life expectancy, followed by educational attainment, with variations across different age groups and gender. This underscores the importance of tailored interventions that consider the specific needs of older adults individuals in diverse geographical areas and age brackets to extend life expectancy and promote health equity. By tackling these unfair differences, health equity can be ensured and the overall well-being of the older population in both urban and rural areas can be improved.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1439857"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic status correlates with clinical outcomes in patients with acral melanoma.","authors":"Rong Huang, Jiayu Wang, Kelin Zheng, Mengke Zhao, Zhengyun Zou","doi":"10.3389/fpubh.2025.1496082","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1496082","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the impact of socioeconomic status on survival in Chinese patients with acral melanoma.</p><p><strong>Methods: </strong>We collected clinical and socioeconomic information of 298 primary acral melanoma patients and performed Kaplan-Meier curves, log-rank tests, Cox proportional hazards models, and Pearson's chi-squared tests to evaluate the relationships between clinical characteristics, socioeconomic factors, and survival outcomes.</p><p><strong>Results: </strong>Among the clinical characteristics, age, gender, stage, Breslow thickness, and primary tumor site significantly impacted survival in acral melanoma patients (<i>p</i> = 0.01, <i>p</i> = 0.05, <i>p</i> < 0.01, <i>p</i> < 0.01, <i>p</i> < 0.01, respectively). Compared to individual socioeconomic factors such as education, occupation, medical insurance, and marital status, the socioeconomic level derived from these four dimensions accurately predicted patient survival. Patients with higher socioeconomic status demonstrated significantly reduced mortality risk (HR = 0.60, 95% CI = 0.40-0.91, <i>p</i> = 0.02). However, socioeconomic level was not found to be an independent prognostic factor for acral melanoma patients after multivariable adjustment. Notably, a negative correlation was observed between socioeconomic level and Breslow thickness.</p><p><strong>Conclusion: </strong>Socioeconomic level is associated with survival in Chinese acral melanoma patients. However, this association may be attributable to Breslow thickness rather than socioeconomic status itself.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1496082"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world cost-effectiveness of nirmatrelvir-ritonavir as treatment for SARS-CoV-2 infection in the Belgian setting with omicron variant.","authors":"Sophie Marbaix, Steven Simoens, Philippe Clevenbergh, Pascal Van Bleyenbergh, Keliane Liberman, Dimitri Dehenau","doi":"10.3389/fpubh.2024.1432821","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1432821","url":null,"abstract":"<p><strong>Background: </strong>Nirmatrelvir-ritonavir is an oral treatment for SARS-CoV-2 infection in patients who are at high risk of developing severe COVID-19 disease. This antiviral has proven to significantly reduce the risk of hospitalization and death compared to no anti-SARS-CoV-2 treatment in this target population. This paper aims to assess the cost-effectiveness of nirmatrelvir-ritonavir in Belgium using real-world evidence.</p><p><strong>Methods: </strong>A static decision tree model was developed to capture the health progression of patients infected with the SARS-CoV-2 virus. Outcomes were expressed in Quality Adjusted-Life Years (QALYs), hospitalizations, Intensive Care Unit (ICU) admissions, deaths and Long Covid cases, derived from epidemiological data over the first full year of the Omicron variant's circulation (2022). Costs were calculated for the year 2023 from the healthcare payer's perspective. Extensive sensitivity analyses were conducted to test the robustness of the cost-effectiveness results.</p><p><strong>Results: </strong>In a cohort of 1,000 patients, treatment with nirmatrelvir-ritonavir is projected to save 95 QALYs and €82,658 compared to no anti-SARS-CoV-2 treatment over a lifetime horizon. These savings primarily stem from the reduction in hospitalizations among vulnerable patients who typically require a longer recovery time. The analysis also indicates 5 fewer ICU admissions and 8 fewer premature deaths per 1,000 infected patients.</p><p><strong>Conclusion: </strong>In the context of Omicron SARS-CoV-2 infection, administering nirmatrelvir-ritonavir to patients at high risk of severe disease improves health outcomes and reduces costs. Nirmatrelvir-ritonavir is 100% likely to be cost-effective at a willingness to pay of €2,000 per QALY.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"12 ","pages":"1432821"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying hope: an EU perspective of rare disease therapeutic space and market dynamics.","authors":"Emmanuelle Cacoub, Nathalie Barreto Lefebvre, Dimitrije Milunov, Manish Sarkar, Soham Saha","doi":"10.3389/fpubh.2025.1520467","DOIUrl":"https://doi.org/10.3389/fpubh.2025.1520467","url":null,"abstract":"<p><p>Rare diseases, affecting millions globally, pose a significant healthcare burden despite impacting a small population. While approximately 70% of all rare diseases are genetic and often begin in childhood, diagnosis remains slow and only 5% have approved treatments. The UN emphasizes improved access to primary care (diagnostic and potentially therapeutic) for these patients and their families. Next-generation sequencing (NGS) offers hope for earlier and more accurate diagnoses, potentially leading to preventative measures and targeted therapies. In here, we explore the therapeutic landscape for rare diseases, analyzing drugs in development and those already approved by the European Medicines Agency (EMA). We differentiate between orphan drugs with market exclusivity and repurposed existing drugs, both crucial for patients. By analyzing market size, segmentation, and publicly available data, this comprehensive study aims to pave the way for improved understanding of the treatment landscape and a wider knowledge accessibility for rare disease patients.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1520467"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}