Relationship between the level of mixed chemicals in male urine and the prevalence of male cancers, especially prostate cancer.

IF 3 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Frontiers in Public Health Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.3389/fpubh.2025.1544174

Bin Zhang, Hao Sun, Bin Zhu, Mengmeng Wang, Bingli Zuo, Jiuming Dai

{"title":"Relationship between the level of mixed chemicals in male urine and the prevalence of male cancers, especially prostate cancer.","authors":"Bin Zhang, Hao Sun, Bin Zhu, Mengmeng Wang, Bingli Zuo, Jiuming Dai","doi":"10.3389/fpubh.2025.1544174","DOIUrl":null,"url":null,"abstract":"Objectives: The aim of this study was to investigate the relationship between mixed chemicals in urine and the prevalence of cancers in men.Methods: A total of 1,068 male subjects were included in this study. Analyses were performed by several analytical methods to ensure the stability of the results: one-way analysis, WQS analysis, Qgcomp analysis, BKMR analysis, and Restricted Cubic Spline (RCS).Results: In the final adjusted model, each 1 increase in ln-transformed BPS increased the risk of developing cancerous prostate by 49% (95% CI: 1.00-2.20). The results of multiple sensitivity analyses by WQS and Qgcomp showed that the mixed chemicals was positively correlated with the prevalence of cancers and prostate cancer in men. In the final adjusted model, each quartile increase in the WQS index was associated with a 78% (OR: 1.78, 95% CI: 1.10-2.87) increase in the risk of cancers and a 148% (OR: 2.48, 95% CI: 1.07-5.71) increase in the risk of prostate cancer. Each quartile increase in the Qgcomp index was associated with a 59% (OR: 1.59, 95% CI: 1.09-2.33) increase in the risk of cancers, and a 105% (OR: 2.05, 95% CI: 1.04-4.06) increase in the risk of prostate cancer.Conclusion: In conclusion, this study showed a positive correlation between the concentrations of the three groups of mixed chemicals in urine and the prevalence of cancers in men, as well as a positive correlation with the prevalence of prostate cancer.","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1544174"},"PeriodicalIF":3.0000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938062/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fpubh.2025.1544174","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: The aim of this study was to investigate the relationship between mixed chemicals in urine and the prevalence of cancers in men.

Methods: A total of 1,068 male subjects were included in this study. Analyses were performed by several analytical methods to ensure the stability of the results: one-way analysis, WQS analysis, Qgcomp analysis, BKMR analysis, and Restricted Cubic Spline (RCS).

Results: In the final adjusted model, each 1 increase in ln-transformed BPS increased the risk of developing cancerous prostate by 49% (95% CI: 1.00-2.20). The results of multiple sensitivity analyses by WQS and Qgcomp showed that the mixed chemicals was positively correlated with the prevalence of cancers and prostate cancer in men. In the final adjusted model, each quartile increase in the WQS index was associated with a 78% (OR: 1.78, 95% CI: 1.10-2.87) increase in the risk of cancers and a 148% (OR: 2.48, 95% CI: 1.07-5.71) increase in the risk of prostate cancer. Each quartile increase in the Qgcomp index was associated with a 59% (OR: 1.59, 95% CI: 1.09-2.33) increase in the risk of cancers, and a 105% (OR: 2.05, 95% CI: 1.04-4.06) increase in the risk of prostate cancer.

Conclusion: In conclusion, this study showed a positive correlation between the concentrations of the three groups of mixed chemicals in urine and the prevalence of cancers in men, as well as a positive correlation with the prevalence of prostate cancer.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.