Frontiers in Public Health最新文献

{"title":"Syndromic and biological screening for sexually transmitted infections in female sex workers in Côte d'Ivoire: the ANRS 12381 PRINCESSE cohort study.","authors":"Marcellin N'zebo Nouaman, Patrick Ahuatchi Coffie, Aline A Agoua, Clémence Zébago, Hervé Z Dao, Evelyne Kissi, Severin Lenaud, Mian Anatole, Valentine Becquet, Mélanie Plazy, François Dabis, Serge Eholie, Joseph Larmarange","doi":"10.3389/fpubh.2025.1535122","DOIUrl":"10.3389/fpubh.2025.1535122","url":null,"abstract":"<p><strong>Background: </strong>Female sex workers (FSWs) are at high risk of contracting STIs, in particular in Sub-Saharan Africa. The implementation of oral HIV pre-exposure prophylaxis provided an opportunity to draw attention to the sexual health needs of FSWs. Innovative strategies to screen for and reduce the burden of STIs is thus a priority. This study describes STI screening among FSWs enrolled in the PRINCESSE project in Côte d'Ivoire.</p><p><strong>Methods: </strong>The PRINCESSE project (2019-2023) was an interventional cohort of FSWs ≥18 years, evaluating a comprehensive, community-based sexual and reproductive health care package, including the management of STIs, offered through mobile clinics operating on prostitution sites in San Pedro area. HIV testing and syndromic STI testing were offered at baseline and every 3 months. Biological testing of <i>Chlamydia trachomatis</i> (CT) and <i>Neisseria gonorrhoeae</i> (NG) was offered annually. Clinical forms included sociodemographic, behavioral and sex-work-related characteristics. We describe baseline characteristics, coverage of clinical examination, and vaginal, anal swab collection. Social, behavioral and sex work-related factors associated with an STI syndromic diagnosis were explored. A multivariable logistic regression model was used to identify factors associated with diagnosing a symptomatic STI.</p><p><strong>Results: </strong>489 FSWs were included in the PRINCESSE cohort. Median age was 29 years (24-35 years), 28.6% had had sex without a condom in the last 7 days. The prevalence of HIV at baseline was 10.5%. Only one case of HIV seroconversion was observed during the project. The most frequent symptom was ano-vaginal discharge (19.1%). The prevalence of STI based on clinical symptoms was 26.6%. The proportion of vaginal swab samples for which the PCR result was positive was 8.0% for CT and 4.0% for NG. Only age remained significantly associated with diagnosing a symptomatic STI in the multivariable analysis.</p><p><strong>Conclusion: </strong>This study revealed a high prevalence of HIV and STIs, similar to national estimates among FSWs enrolled in a sexual health cohort. Screening for these generically asymptomatic bacterial STIs must be combined with the syndromic approach used in key populations, especially with the introduction of new PrEP programs, to reduce the exposure of individuals in these populations to STIs.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1535122"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telehealth perceptions and associated factors among older adults with chronic conditions in Saudi Arabia: a comparative study of users and non-users.","authors":"Abdulkarim M Meraya, Amani Khardali, Sarfaraz Ahmad, Ahmed Z Hoshaibari, Atheer A Alameer, Raed Y Jaafari, Hilal A Thaibah, Moaddey Alfarhan, Mamoon H Syed","doi":"10.3389/fpubh.2025.1542974","DOIUrl":"10.3389/fpubh.2025.1542974","url":null,"abstract":"<p><strong>Background: </strong>Telehealth is a promising approach for healthcare delivery that uses telecommunication technologies to enhance accessibility by providing remote health services. This study aimed to identify psychosocial factors that best predict behavioral intention to use telehealth/telemedicine, as mediated by attitude toward use, among older adults with chronic conditions in the Jazan region of Saudi Arabia, and to compare users and non-users.</p><p><strong>Methods: </strong>Participants were aged 60 years or above, residing in Jazan, and presenting with at least one chronic condition. This study used a quantitative research approach with a cross-sectional questionnaire survey. We stratified all analyses by telehealth use status (users or non-users).</p><p><strong>Results: </strong>Our study sample comprised 466 participants aged 60 or above with at least one chronic condition. The most prevalent condition was diabetes (29%), followed by arthritis (23%). Among the telehealth users (n = 256), a high percentage (42%) reported that telehealth was better than in-person appointments. Among telehealth users, we found that perceived usefulness [(users: β = 0.501; <i>p</i> < 0.001) (non-users: β = 0.441; <i>p</i> < 0.001)] and facilitating conditions [(users: β = 0.768; <i>p</i> = 0.001) (non-users: β = 0.807; <i>p</i> < 0.001)] positively affected attitudes to using telehealth. Telehealth users and non-users reported dislike or fear of the service and unavailability of appointments as the most important barriers to using telehealth services.</p><p><strong>Conclusion: </strong>The results of this study are important for designing new telehealth applications, especially for older adults in Saudi Arabia. Designers and developers must understand that the attributes and capabilities of telehealth applications should be simple and user-friendly to encourage older adults to increase their intention to use telehealth.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1542974"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing male involvement in childcare and associated factors among fathers of below two in Toke Kutaye district, Central Ethiopia, 2024: a community-based cross-sectional study.","authors":"Gemechu Ganfure, Jiregna Darega, Latera Debebe Kitila","doi":"10.3389/fpubh.2025.1527675","DOIUrl":"10.3389/fpubh.2025.1527675","url":null,"abstract":"<p><strong>Background: </strong>Male involvement in child care is increasingly acknowledged as a crucial factor for promoting positive health and developmental outcomes for children, particularly during the critical early years of life. In Ethiopia, low male participation in child-rearing exacerbates public health issues, including high neonatal and under-five mortality rates. This study examines the prevalence and factors associated with paternal involvement in child care among fathers of children under 2 years in Toke Kutaye District, Central Ethiopia.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted from January 28 to February 16, 2024. A total of 605 fathers with children under 2 years were randomly selected for interviews. Data on male involvement in child care were collected using a structured questionnaire. Data were entered using Epi-data version 3.1 and analyzed using SPSS version 26. Bi-variable and multivariable logistic regression analyses were performed, applying adjusted odds ratios (AOR) with 95% confidence intervals (CI) to assess statistical significance, with a <i>p</i> < 0.05. Descriptive statistics were also computed and presented using text, charts, and tables.</p><p><strong>Results: </strong>The study found that 36.7% of fathers exhibited good involvement in childcare practices. While a majority contributed financially (55.6%) and engaged in play (55.4%), significantly fewer fathers participated in essential caregiving activities like feeding (27.3%) or seeking healthcare during illness (17.1%). Multivariable analysis identified significant predictors of paternal involvement: completing secondary education (AOR = 5.24, 95% CI: 2.64-10.38), having male children (AOR = 1.69, 95% CI: 1.094-2.62), first birth order (AOR = 5.66, 95% CI: 2.79-11.45), and fewer family size (AOR = 4.82, 95% CI: 2.58-9.016).</p><p><strong>Conclusion: </strong>This study underscores the limited yet essential role of fathers in child care within the Toke Kutaye District, revealing a need for targeted interventions to enhance paternal engagement. Promoting educational initiatives could serve as a strategy to foster deeper paternal participation in child-rearing practices, ultimately contributing to improved health and developmental outcomes for children.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1527675"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the ECHOES national dataset: a resource for monitoring post-acute and long-term COVID-19 health outcomes in England.","authors":"Hester Allen, Katie Hassell, Christopher Rawlinson, Owen Pullen, Colin Campbell, Annika M Jödicke, Martí Català, Albert Prats-Uribe, Gavin Dabrera, Daniel Prieto-Alhambra, Ines Campos-Matos","doi":"10.3389/fpubh.2025.1513508","DOIUrl":"10.3389/fpubh.2025.1513508","url":null,"abstract":"<p><strong>Introduction: </strong>Electronic health records can be used to understand the diverse presentation of post-acute and long-term health outcomes following COVID-19 infection. In England, the UK Health Security Agency, in collaboration with the University of Oxford, has created the Evaluation of post-acute COVID-19 Health Outcomes (ECHOES) dataset to monitor how an initial SARS-CoV-2 infection episode is associated with changes in the risk of health outcomes that are recorded in routinely collected health data.</p><p><strong>Methods: </strong>The ECHOES dataset is a national-level dataset combining national-level surveillance, administrative, and healthcare data. Entity resolution and data linkage methods are used to create a cohort of individuals who have tested positive and negative for SARS-CoV-2 in England throughout the COVID-19 pandemic, alongside information on a range of health outcomes, including diagnosed clinical conditions, mortality, and risk factor information.</p><p><strong>Results: </strong>The dataset contains comprehensive COVID-19 testing data and demographic, socio-economic, and health-related information for 44 million individuals who tested for SARS-CoV-2 between March 2020 and April 2022, representing 15,720,286 individuals who tested positive and 42,351,016 individuals who tested negative.</p><p><strong>Discussion: </strong>With the application of epidemiological and statistical methods, this dataset allows a range of clinical outcomes to be investigated, including pre-specified health conditions and mortality. Furthermore, understanding potential determinants of health outcomes can be gained, including pre-existing health conditions, acute disease characteristics, SARS-CoV-2 vaccination status, and genomic variants.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1513508"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating double burden of malnutrition among rural and urban children in Amazonia using Bayesian latent models.","authors":"Jesem Douglas Yamall Orellana, Luke Parry, Francine Silva Dos Santos, Laísa Rodrigues Moreira, Patricia Carignano Torres, Antônio Alcirley da Silva Balieiro, Fernanda Rodrigues Fonseca, Paula Moraga, Erick Albacharro Chacón-Montalván","doi":"10.3389/fpubh.2025.1481397","DOIUrl":"10.3389/fpubh.2025.1481397","url":null,"abstract":"<p><strong>Background: </strong>The double burden of malnutrition (DBM) in the same individual is a neglected public health concern, especially in low- and middle-income countries (LMICs). The DBM is associated with increased risks of non-communicable diseases, childbirth complications, and healthcare costs related to obesity in adulthood. However, evaluating low prevalence outcomes in relatively small populations is challenging using conventional frequentist statistics. Our study used Bayesian latent models to estimate DBM prevalence at the individual-level in small populations located in remote towns and rural communities in the Brazilian Amazon.</p><p><strong>Methods: </strong>We employed a cross-sectional survey of urban and rural children aged 6-59 months, considering DBM as the coexistence of stunting and overweight in the same individual. We evaluated four river-dependent municipalities, sampling children in randomly selected households in each town and a total of 60 riverine forest-proximate communities. Through Bayesian modeling we estimated the latent double burden of malnutrition (LDBM) and credible intervals (CI).</p><p><strong>Results: </strong>The exceedance probability of LDBM was used to quantify this form of malnutrition at the population level. Rural prevalence of LDBM was significantly higher in Jutai (3.3%; CI: 1.5% to 6.7%) compared to Maues and Caapiranga. The likelihood that LDBM rural prevalence exceeded 1% was very high in Jutai (99.7%), and Ipixuna (63.2%), and very low (< 2%) in rural communities elsewhere. Exceedance probabilities (at 1%) also varied widely among urban sub-populations, from 6.7% in Maues to 41.2% in Caapiranga. The exceedance probability of LDBM prevalence being above 3.0% was high in rural Jutai (59.7%).</p><p><strong>Discussion: </strong>Our results have important implications for assessing DBM in vulnerable and marginalized populations, where health and nutritional status are often poorest, and public health efforts remain focused on undernutrition. Our analytical approach could enable more accurate estimation of low prevalence health outcomes, and strengthen DBM monitoring of hard-to-reach populations.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1481397"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the factor structure of the Physical Literacy for Life self-assessment tool (PL4L) among Japanese adults and its relationship with the stages of change model for participation in regular physical activity.","authors":"Misaki Matsunaga, Koya Suzuki, Masahiro Matsui, Kenta Toyama, Shizuo Ito, Yoshinori Okade, Kosho Kasuga, Pengyu Deng, Tetsuya Matsuo, Yasunori Morioka, Hiroshi Aono, Hisashi Naito","doi":"10.3389/fpubh.2025.1505502","DOIUrl":"10.3389/fpubh.2025.1505502","url":null,"abstract":"<p><strong>Introduction: </strong>Physical literacy contributes to physical activity and comprises four conceptually interrelated domains: physical, emotional, social, and cognitive. The International Sport and Culture Association proposed the Physical Literacy for Life self-assessment tool (PL4L); however, its factor structure and usability are not clear. This study aimed to examine the factor structure and internal consistency of the PL4L in adults and its association with the stages of change model for participation in regular physical activity.</p><p><strong>Methods: </strong>For this study, a total of 940 Japanese adults (age: 41.8 ± 13.2 years) completed a web-based cross-sectional survey. Physical literacy (PL) was assessed using the PL4L. The stages of change model regarding participation in regular physical activity were examined using a self-reported questionnaire that applied the Transtheoretical Model. Internal consistency was assessed by Cronbach's α and McDonald's ω. Factor structure was evaluated using confirmatory factor analysis. Structural equation modeling was used to investigate the relationship between the PL4L and the stages of change for participation in regular physical activity. Internal consistency coefficients were found to be high.</p><p><strong>Results: </strong>In the confirmatory factor analysis, the modified model, incorporating theoretically justified error covariances, demonstrated a good fit. The factor loadings between domains and items were all significant. Significant associations were also identified between PL and stages of change for participation in regular physical activity.</p><p><strong>Discussion: </strong>The PL4L's factor structure is consistent with the concept of physical literacy among Japanese adults, which correlates with the stages of change for participation in regular physical activity. Future studies should investigate whether addressing PL can effectively increase physical activity levels.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1505502"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-relationships of depression and anxiety symptoms among widowed and non-widowed older adults: findings from the Chinese Longitudinal Healthy Longevity Survey based on network analysis and propensity score matching.","authors":"Yinglin Li, Doudou Lin, Xuan Gong, Dou Fu, Ling Zhao, Weibing Chen, Jie Chen, Shanshan Liu, Guirong Yang, Zhongxiang Cai","doi":"10.3389/fpubh.2025.1495284","DOIUrl":"10.3389/fpubh.2025.1495284","url":null,"abstract":"<p><strong>Background: </strong>Depression and anxiety are prevalent mental health issues among older adult widowed adults. However, the symptom-level relationships between these conditions remain unclear. Due to the high correlations and complex relationships among various symptoms, this study employs network analysis to explore differences in the network structures of depression and anxiety symptoms between widowed and non-widowed older adults.</p><p><strong>Methods: </strong>Propensity score matching was used to identify widowed older adults with similar demographic characteristics. Data from 1,736 widowed and 1,736 matched controls were analyzed using the Chinese Longitudinal Healthy Longevity Survey (2017-2018). Depression and anxiety were measured by the Center for Epidemiologic Studies Depression Scale-10 (CESD-10) and the seven-item Generalized Anxiety Disorder Scale (GAD-7), respectively. Central and bridge symptoms were evaluated using expected influence (EI) and bridge expected influence (BEI), respectively.</p><p><strong>Results: </strong>Network analysis revealed similarities in central symptoms between widowed and non-widowed older adults, with both groups exhibiting \"Feeling depressed or down\" (CESD3), \"Feeling tense and having difficulty relaxing\" (GAD4), and \"Being unable to stop or control worrying\" (GAD2) as core symptoms. However, differences emerged in bridge symptoms. In the widowed group, \"Feeling anxious, worried, or distressed\" (GAD1) was most strongly connected to \"Felt lonely\" (CESD8); \"Worrying too much about various things\" (GAD3) was strongly linked to \"Feeling increasingly exhausted and useless with age\" (CESD4); and \"Feeling depressed or down\" (CESD3) had a strong association with \"Becoming easily annoyed or irritable\" (GAD6). In the non-widowed group, \"Feeling anxious, worried, or distressed\" (GAD1) exhibited the strongest association with \"Having good sleep quality\" (CESD10); \"Getting upset over small matters\" (CESD1) was closely connected to \"Feeling anxious, worried, or distressed\" (GAD1); and \"Worrying too much about various things\" (GAD3) was most strongly connected to \"Feeling depressed or down\" (CESD3).</p><p><strong>Conclusion: </strong>Common central and bridge symptoms highlight universal intervention targets. Addressing \"Feeling depressed or down\" in widowed and \"Getting upset over small matters\" in non-widowed older adults may help prevent depression-anxiety comorbidity. These findings support targeted interventions to improve mental health outcomes. Future research should evaluate tailored intervention effectiveness.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1495284"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction effects of sleep duration and activities of daily living on depressive symptoms among Chinese middle-aged and older adult individuals: evidence from the CHARLS.","authors":"Tianmeng Wang, Wenjin Han, Caihua Wang, Yanqing Kang, Yaping Wang, Shuangyan Lei, Zhaozhao Hui, Ning Li, Xiaoqin Wang","doi":"10.3389/fpubh.2025.1547329","DOIUrl":"10.3389/fpubh.2025.1547329","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence on the combined effect of sleep duration and activities of daily living (ADL) on depressive symptoms is scarce. This study aimed to explore the interaction effects between sleep duration and ADL limitations on depressive symptoms among Chinese individuals aged ≥45 years.</p><p><strong>Methods: </strong>Data were extracted from the China Health and Retirement Longitudinal Study (CHARLS) wave 2020. Sleep duration was self-reported. The Center for Epidemiological Studies Depression Scale and a 12-item scale were employed to estimate depressive symptoms and ADL limitations, respectively. Logistic regression analysis was conducted to examine the interaction effects between sleep duration and ADL limitations on depressive symptoms.</p><p><strong>Results: </strong>Logistic regression found that short sleep (OR = 1.69, 95% CI: 1.57-1.83), long sleep (OR = 0.87, 95% CI: 0.79-0.95), and ADL limitations [basic activities of daily living (BADL), OR = 1.82, 95% CI: 1.66-2.01; instrumental activities of daily living (IADL), OR = 1.88, 95% CI: 1.71-2.07] were associated with depressive symptoms. Furthermore, synergistic interaction effects on the depressive symptoms risk were identified between short sleep and IADL limitations (RERI = 1.08, 95% CI: 0.57-1.59) or BADL limitations (RERI = 1.13, 95% CI: 0.60-1.65). Conversely, antagonistic interaction effects were observed between long sleep and IADL limitations (RERI = 0.88, 95% CI: 0.39-1.38) or BADL limitations (RERI = 0.76, 95% CI: 0.25-1.27) on depressive symptoms.</p><p><strong>Conclusion: </strong>The study revealed significant interactions between sleep duration and ADL limitations on depressive symptoms, suggesting that enhancing ADL's function and ensuring adequate sleep duration could effectively prevent depressive symptoms.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1547329"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ethylene oxide exposure with serum neurofilament light chain levels among American adults.","authors":"Xiuwen Yang, Huaili Feng, Ting You, Zhaoyi Liu, Fanwei Sun, Chengzhi Chen, Jingfu Qiu","doi":"10.3389/fpubh.2025.1545164","DOIUrl":"10.3389/fpubh.2025.1545164","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between Ethylene oxide (EO) expousure and serum neurofilament light chain (NfL).</p><p><strong>Method: </strong>A data of 559 adults from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) was analyzed, and the relationship between log-transformed EO hemoglobin adducts (HbEO) and serum NfL levels was assessed using multiple linear regression models and restricted cubic spline functions. Stratified analysis was conducted to explore the correlations within different subgroups. Mediation analysis was employed to investigate potential mediating factors.</p><p><strong>Results: </strong>The higher HbEO levels were consistently associated with elevated serum NfL concentrations among the study participants (<i>β</i> = 0.07, 95%CI: 0.00-0.14; <i>p</i> = 0.044), and serum NfL levels increased with rising HbEO levels (<i>p</i> for trend = 0.013). The restricted cubic spline results confirmed the linear relationship between serum NfL and HbEO. Subgroup analysis indicated a significant positive correlation, particularly among non-Hispanic white people, individuals aged 40-59, and heavy drinkers.</p><p><strong>Conclusion: </strong>These findings highlighted the neurotoxic potential of EO and underscored the importance of monitoring EO exposure to mitigate its adverse health effects.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1545164"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a multicomponent intervention to promote physical activity during the school day: rationale and methods of the MOVESCHOOL study.","authors":"Francisco J Bandera-Campos, Alberto Grao-Cruces, Daniel Camiletti-Moirón, Fátima Martín-Acosta, Raúl Muñoz-González, María González-Pérez, Abel Ruiz-Hermosa, Miguel Vaquero-Solís, Carmen Padilla-Moledo, David Sánchez-Oliva","doi":"10.3389/fpubh.2025.1565914","DOIUrl":"10.3389/fpubh.2025.1565914","url":null,"abstract":"<p><strong>Background: </strong>Increasing levels of physical activity (PA) and reducing sedentary time among adolescents during the school day is a pressing need. Emerging methodologies and strategies been shown to be effective in increasing PA levels and providing additional benefits for students, such us physically active lessons (PAL), active breaks (AB) and active recesses (AR). However, evidence concerning adolescents remains limited. This manuscript presents the methods and rationale of the MOVESCHOOL study, which aims was to examine the effects of a multicomponent school-based intervention during the school day on indicators of PA, sedentary time, health, executive functions and education in adolescents.</p><p><strong>Methods: </strong>A quasi-experimental study was conducted with the aim to involve a total of 800 students aged 12-14 years old from 11 schools (7th and 8th grade) in south-western Spain, five schools forming the intervention group and six schools forming the control group. The evaluation included two independent measurements: pre-intervention and post-intervention. The intervention lasted 29 weeks and consisted of a multi-component programme including a weekly PAL, two 5 min daily AB, and a daily AR. Primary outcomes included accelerometer-based PA and sedentary time, health-related physical fitness, academic indicators, and executive functions. For statistical analyses, descriptive, correlational, regression, and repeated measures ANOVA analyses will be applied. Additionally, qualitative data were gathered through semi-structured individual interviews and focus groups, and information will be evaluated with thematic analysis.</p><p><strong>Discussion: </strong>The MOVESCHOOL study represents a pioneering effort in Spain, being the first of its kind to evaluate the effectiveness of a multicomponent programme in secondary schools. Furthermore, this project provides valuable insights into the effects of a multicomponent school-based PA intervention on PA levels, sedentary time, health-related, cognitive, academic indicators and psychological health markers in secondary school students. The results of this study will make a significant contribution to the educational community, providing them with innovative teaching methods and strategies that have the potential to increase PA levels during the school day. In addition, this research promises to provide a transformative experience for educators, equipping them with tools to promote the holistic development of their students, enriching their academic performance and enhancing their well-being.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, identifier NCT06254638.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"13 ","pages":"1565914"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}