Association of ethylene oxide exposure with serum neurofilament light chain levels among American adults.

IF 3 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Frontiers in Public Health Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.3389/fpubh.2025.1545164

Xiuwen Yang, Huaili Feng, Ting You, Zhaoyi Liu, Fanwei Sun, Chengzhi Chen, Jingfu Qiu

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引用次数: 0

Abstract

Objective: To explore the relationship between Ethylene oxide (EO) expousure and serum neurofilament light chain (NfL).

Method: A data of 559 adults from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) was analyzed, and the relationship between log-transformed EO hemoglobin adducts (HbEO) and serum NfL levels was assessed using multiple linear regression models and restricted cubic spline functions. Stratified analysis was conducted to explore the correlations within different subgroups. Mediation analysis was employed to investigate potential mediating factors.

Results: The higher HbEO levels were consistently associated with elevated serum NfL concentrations among the study participants (β = 0.07, 95%CI: 0.00-0.14; p = 0.044), and serum NfL levels increased with rising HbEO levels (p for trend = 0.013). The restricted cubic spline results confirmed the linear relationship between serum NfL and HbEO. Subgroup analysis indicated a significant positive correlation, particularly among non-Hispanic white people, individuals aged 40-59, and heavy drinkers.

Conclusion: These findings highlighted the neurotoxic potential of EO and underscored the importance of monitoring EO exposure to mitigate its adverse health effects.

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来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.