Geriatrics & Gerontology International最新文献

{"title":"Dysphagia and quality of life in older adults receiving home-based medical care","authors":"Kazuhisa Watanabe, Masaaki Nagae, Shuzo Miyahara, Hiroyuki Umegaki","doi":"10.1111/ggi.15071","DOIUrl":"10.1111/ggi.15071","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"325-326"},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting admission for fall-related injuries in older adults using artificial intelligence: A proof-of-concept study","authors":"Nam Le,&nbsp;Milan Sonka,&nbsp;Dionne A Skeete,&nbsp;Kathleen S Romanowski,&nbsp;Colette Galet","doi":"10.1111/ggi.15066","DOIUrl":"10.1111/ggi.15066","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Pre-injury frailty has been investigated as a tool to predict outcomes of older trauma patients. Using artificial intelligence principles of machine learning, we aimed to identify a “signature” (combination of clinical variables) that could predict which older adults are at risk of fall-related hospital admission. We hypothesized that frailty, measured using the 5-item modified Frailty Index, could be utilized in combination with other factors as a predictor of admission for fall-related injuries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The National Readmission Database was mined to identify factors associated with admission of older adults for fall-related injuries. Older adults admitted for trauma-related injuries from 2010 to 2014 were included. Age, sex, number of chronic conditions and past fall-related admission, comorbidities, 5-item modified Frailty Index, and medical insurance status were included in the analysis. Two machine learning models were selected among six tested models (logistic regression and random forest). Using a decision tree as a surrogate model for random forest, we extracted high-risk combinations of factors associated with admission for fall-related injury.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our approach yielded 18 models. Being a woman was one of the factors most often associated with admission for fall-related injuries. Frailty appeared in four of the 18 combinations. Being a woman, aged 65–74 years and presenting a 5-item modified Frailty Index score &gt;3 predicted admission for fall-related injuries in 80.3% of this population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Using artificial intelligence principles of machine learning, we were able to develop 18 signatures allowing us to identify older adults at risk of admission for fall-related injuries. Future studies using other databases, such as TQIP, are warranted to validate our high-risk combination models. <b>Geriatr Gerontol Int 2025; 25: 232–242</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"232-242"},"PeriodicalIF":2.4,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low trunk muscle mass could predict severe stress urinary incontinence in Asian women","authors":"Weiming Cheng,&nbsp;Sheng-Wen Chen,&nbsp;Yi-Chun Chiu,&nbsp;Yu-Hua Fan","doi":"10.1111/ggi.15064","DOIUrl":"10.1111/ggi.15064","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Adequate pelvic floor support for the urethra is crucial for preventing stress urinary incontinence (SUI). Obesity is an established risk factor for SUI. This study aimed to explore the relationship between SUI and body composition, specifically focusing on muscle and fat mass.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center, prospective, cross-sectional study enrolled women who visited the genitourinary clinic of Taipei City Hospital-Zhongxiao Branch between 1 February 2020 and 31 January 2021. SUI severity was classified according to the type of daily activity in which SUI occurred. Potential risk factors for SUI, including age, labor and history of hysterectomy, were also included. All participants underwent a bioelectric impedance analysis of their body composition. Independent <i>t</i>-tests and Pearson's χ²-tests were used to compare the differences in continuous and categorical parameters between groups. Logistic regression analysis was used to characterize the predictive value of body composition for severe SUI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 256 included patients, 37 had severe SUI. The participants with severe SUI were older and were more likely to have undergone a hysterectomy. They also had a considerably higher prevalence of sarcopenia. In the univariate analysis, a sarcopenia diagnosis was associated with severe SUI. Furthermore, a history of hysterectomy correlated with severe SUI, although with borderline significance. In the multivariate analysis, a history of hysterectomy and lower trunk muscle mass index were found to be independent predictors of severe SUI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A history of hysterectomy and a lower trunk muscle mass index are correlated with severe SUI. <b>Geriatr Gerontol Int 2025; 25: 226–231</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"226-231"},"PeriodicalIF":2.4,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workload and emotional exhaustion among older assistant care workers in Japan: Buffering effect of work resources","authors":"Panpan Ma,&nbsp;Tomoya Sagara,&nbsp;Mai Takase,&nbsp;Keiko Sugiura,&nbsp;Isuzu Nakamoto,&nbsp;Yoko Muto,&nbsp;Kentaro Higashi,&nbsp;Yoshinori Fujiwara,&nbsp;Hiroshi Murayama","doi":"10.1111/ggi.15058","DOIUrl":"10.1111/ggi.15058","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Based on the Job Demands–Resources model, this study aimed to assess the predictive effect of workload on emotional exhaustion and test the buffering effect of three types of work resources (workplace cohesion, work control, and workplace support) on the relationship between workload and emotional exhaustion among older Japanese assistant care workers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from a national survey on the work features and work-related outcomes of 1601 older assistant care workers working in geriatric health services facilities in Japan. Demographic characteristics, workload, work resources, and emotional exhaustion were analyzed. A hierarchical multiple regression analysis and simple slope test were conducted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Workload had a significant main effect in predicting emotional exhaustion (β = 0.337, <i>P</i> &lt; 0.001). Workplace cohesion buffered the negative effect of workload on emotional exhaustion (interaction between workload and workplace cohesion: β = −0.097, <i>P</i> = 0.002). Work control (interaction between workload and work control: β = −0.015, <i>P</i> = 0.585) and workplace support (interaction between workload and workplace support: β = 0.025, <i>P</i> = 0.391) had no buffering effect on the negative impact of workload on emotional exhaustion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Regulating workload and promoting workplace cohesion might be effective strategies for preventing burnout among elderly workers. Investigations into the occupational stress of elderly workers from diverse cultures and work contexts are needed. <b>Geriatr Gerontol Int 2025; 25: 273–278</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"273-278"},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-, age- and season-specific variations in accidental deaths from stumbling falls, bathtub drowning, food choking and traffic injuries among older adults in Japan","authors":"Yuji Aoki,&nbsp;Mao Yamamoto,&nbsp;Takashi Aoki","doi":"10.1111/ggi.15068","DOIUrl":"10.1111/ggi.15068","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to identify opportunities for more effective measures. We analyzed sex-, age- and season-specific trends in unintentional accidental deaths from stumbling falls, bathtub drowning, food choking and traffic injuries among older adults in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Death rates from major unintentional accidents were analyzed by sex, month and 5-year age groups (aged ≥50 years) based on a custom-made aggregation of data from the Vital Statistics survey (2008–2022) in compliance with the Statistics Act.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 2008 to 2022, death rates from the 4 major unintentional accidental causes (11 354 and 11 374 deaths in 19 408 000 men and 24 272 000 women aged ≥60 in 2022) were obviously higher among older men than older women, except for notably high death rates from bathtub drowning among women aged 75–84 years. Significant increases in death rates from stumbling falls were observed in men and women aged ≥85 years, with significant decreases among men aged 60–74 years and women aged 65–74 years. Significant increases in bathtub drowning death rates were observed among men aged 90–94 and ≥100 years, as well as among women aged 90–99 years. Bathtub drowning death rates rose with age but peaked in women aged 85–89 years. Both bathtub drowning and food choking deaths were more frequent during the winter season.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Accidental deaths from stumbling falls and bathtub drowning continue to rise among older Japanese adults in some age groups. Notably, deaths from bathtub drowning were distinctively higher among women aged in their 70s and 80s, possibly including apparently healthy women, during the winter season. <b>Geriatr Gerontol Int 2025; 25: 287–293</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"287-293"},"PeriodicalIF":2.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive impairment and domain-specific life satisfaction among older adults: Findings from the Korean National Longitudinal Study on Aging","authors":"Inmyung Song,&nbsp;Dong-Sook Kim","doi":"10.1111/ggi.15053","DOIUrl":"10.1111/ggi.15053","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Overall life satisfaction among older adults is associated with cognitive impairment. However, little is known regarding its influence on satisfaction with specific domains of life, such as health, income status, and marital relationship. This study aims to analyze the relationship between cognitive impairment and satisfaction with specific domains of life in older Koreans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used data from the Korean National Longitudinal Study on Aging from 2014 to 2020. Cognitive function was measured with the Mini-Mental State Examination. Four different models are used to assess the effect of cognitive impairment on four different measures of life satisfaction. The dependent variable in each model was overall life satisfaction, satisfaction with health status, satisfaction with economic status, and satisfaction with marital relationship, respectively. A generalized estimating equation modeling approach was used to take advantage of panel data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the weighted sample, 54.1% of the participants were women. The mean (± standard error) age of all participants was 68.9 (±0.1) years old. A total of 1671 participants (24.8%) had cognitive impairment. After adjustment of other variables, individuals without cognitive impairment were more satisfied with overall life (B = 2.75, <i>P</i> &lt; 0.001), health status (B = 4.31, <i>P</i> &lt; 0.001), economic status (B = 2.83, <i>P</i> &lt; 0.001) and marital relationship (B = 3.36, <i>P</i> &lt; 0.001) than impaired individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cognitive impairment in old age is significantly associated with overall life satisfaction as well as satisfaction with several domains of life, such as health, income status, and marital relationship. Cognitive impairment is more strongly associated with satisfaction with health status and marital relationship than on satisfaction with economic status. <b>Geriatr Gerontol Int 2025; 25: 182–189</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"182-189"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of eribulin monotherapy for bone marrow carcinomatosis of breast cancer in a patient with Werner syndrome","authors":"Akihito Fujimi,&nbsp;Yasuhiro Nagamachi,&nbsp;Naofumi Yamauchi,&nbsp;Riku Hasebe,&nbsp;Naoki Onoyama,&nbsp;Naotaka Hayasaka,&nbsp;Teppei Matsuno,&nbsp;Kazuhiko Koike,&nbsp;Yoshiro Gotoh,&nbsp;Kohji Ihara,&nbsp;Junji Kato,&nbsp;Takuji Nishisato,&nbsp;Kazuyuki Murase,&nbsp;Goro Kutomi,&nbsp;Tokimasa Hida,&nbsp;Hisashi Uhara,&nbsp;Kohichi Takada","doi":"10.1111/ggi.15070","DOIUrl":"10.1111/ggi.15070","url":null,"abstract":"<p>Various complications and potential risks of serious adverse events lessens the intensity of chemotherapy in patients with Werner syndrome. Bone marrow carcinomatosis of breast cancer was developed in a patient with Werner syndrome. Eribulin proved well tolerated and effective in improving severe thrombocytopenia, leading to platelet transfusion-free status.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"316-318"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the factors contributing to symptoms worsening in elderly care-facility residents with dementia: Difficulties encountered in dealing with COVID-19 clusters","authors":"Junpei Tanabe,&nbsp;Hungu Jung,&nbsp;Yuji Iwamoto,&nbsp;Shinya Ishii","doi":"10.1111/ggi.15057","DOIUrl":"10.1111/ggi.15057","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"323-325"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for dysphagia in older people: A validation study of the psychometric properties of the Danish 4 Question Test (4QT-DK)","authors":"Sabina Mette Staal,&nbsp;Karl Bang Christensen,&nbsp;David Smithard,&nbsp;Albert Westergren,&nbsp;Dorte Melgaard","doi":"10.1111/ggi.15050","DOIUrl":"10.1111/ggi.15050","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The four-item questionnaire test (4QT) is a simple screening measure of dysphagia for older people. A positive answer to any item indicates the need for further assessment. The 4QT is fast, simple to apply and requires no training beforehand. However, it is not translated to Danish, and the psychometric properties in an older Danish population are unknown. The aim was to translate the 4QT to Danish, determine criterion validity according to the existing measures, the Minimal Eating Observation Form-II (MEOF-II) and Volume-Viscosity Swallow Test (V-VST), and determine construct and structural validity and reliability by exploring whether 4QT fits the assumptions of the Rasch model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The 4QT was translated and back-translated. A total of 73 participants aged ≥65 years were included and screened with the 4QT-DK, and assessed using the V-VST and MEOF-II. Criterion validity was assessed compared with the V-VST and MEOF-II according to sensitivity, specificity and predictive values. Construct and structural validity were examined using confirmatory factor analysis and Rasch model analysis investigating item and person fit, differential item functioning for sex, age, primary disease and local dependency. Reliability was assessed using Cronbach's coefficient alpha.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For criterion validity, the 4QT-DK showed high sensitivity (84% and 90% with the V-VST and MEOF-II, respectively). As expected, specificity was lower (36%, and 42%). Analyses confirmed the psychometric validity of the 4QT-DK. Reliability was low (Cronbach's alpha = 0.58) due to the number of items.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The 4QT-DK is a valid and sensitive measure for screening older people for dysphagia. Further studies are required to assess the psychometric properties and confirm findings in a larger Danish sample. <b>Geriatr Gerontol Int 2025; 25: 294–299</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"294-299"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of brain volume changes associated with aging: Results from the fourth research on osteoarthritis/osteoporosis against disability survey","authors":"Koji Nakajima,&nbsp;Akitoshi Ogawa,&nbsp;Hiroyasu Kodama,&nbsp;Tomohiko Shirokoshi,&nbsp;Takahiro Osada,&nbsp;Seiki Konishi,&nbsp;Chiaki Horii,&nbsp;Yasushi Oshima,&nbsp;Toshiko Iidaka,&nbsp;Shigeyuki Muraki,&nbsp;Hiroyuki Oka,&nbsp;Hiroshi Kawaguchi,&nbsp;Toru Akune,&nbsp;Hiroshi Hashizume,&nbsp;Hiroshi Yamada,&nbsp;Munehito Yoshida,&nbsp;Kozo Nakamura,&nbsp;Masaaki Shojima,&nbsp;Sakae Tanaka,&nbsp;Noriko Yoshimura","doi":"10.1111/ggi.15033","DOIUrl":"10.1111/ggi.15033","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to investigate the impact of aging on brain volume among community residents in Japan, focusing on trends over time and specific brain structures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from the fourth survey (2015–2016) of the Research on Osteoarthritis/Osteoporosis Against Disability project, encompassing 2146 community residents from Japan's mountainous and coastal regions. A total of 1755 participants (81.8% of the baseline population) underwent extensive data collection including lifestyle and health questionnaires, anthropometric measurements and brain magnetic resonance imaging. The imaging data were processed to examine correlations between total brain volume, gray matter volume (GMV), white matter volume (WMV), cerebrospinal fluid volume and participant age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis showed significant sex differences in total brain volume, with GMV demonstrating a strong negative correlation with age – more pronounced than the moderate negative correlation seen in WMV. Cerebrospinal fluid volume exhibited a strong positive correlation with age. Notably, specific brain regions such as the bilateral amygdala, hippocampus, thalamus and primary motor cortex showed significant age-related volume reductions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study confirms that GMV and WMV are smaller in older individuals in the Japanese population, with more pronounced differences in GMV. The amygdala, hippocampus, thalamus and primary motor cortex were particularly affected. <b>Geriatr Gerontol Int 2025; 25: 279–286</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"279-286"},"PeriodicalIF":2.4,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}