Geriatrics & Gerontology International最新文献

{"title":"Effects of exercise on cognitive function and glycated hemoglobin A1c among patients with type 2 diabetes mellitus and cognitive impairment: A systematic review and meta-analysis","authors":"Xiaoxue Li,&nbsp;Bin Chen,&nbsp;Xinyuan Liu,&nbsp;Jingya Ma","doi":"10.1111/ggi.15061","DOIUrl":"10.1111/ggi.15061","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the effects of exercise versus without-exercise group on global cognitive function, executive function, glycated hemoglobin A1c (HbA1c) and fasting plasma glucose in patients with type 2 diabetes mellitus and cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search of Cqvip, SinoMed, Wanfang Data, CINAHL, Cochrane, Embase, Pubmed, Lippincott, Web of Science and Scopus was carried out. Randomized control trials were selected. The risk of bias was evaluated using the Cochrane Risk of Bias tool. The random-effects model was used to obtain the pooled estimates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight trials with 884 participants were included. Exercise could significantly improve global cognitive function (standardized mean difference 0.82, 95% CI 0.53–1.12), executive function measured by the Trail-Marking Test part B (mean difference −20.43, 95% CI −36.20, −4.66), glycated hemoglobin A1c (%; mean difference −0.58, 95% CI −0.88, −0.29) and fasting plasma glucose (mg/dL; mean difference −17.61, 95% CI −32.67, −2.54).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Exercise can improve cognitive function, glycated hemoglobin A1c and fasting plasma glucose among type 2 diabetes mellitus patients with cognitive impairment. Additional studies with higher methodological quality are expected to draw more definite conclusions. This finding could provide a reference for clinical decision-making and guide future research initiatives. <b>Geriatr Gerontol Int 2025; 25: 148–159</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"148-159"},"PeriodicalIF":2.4,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of age-related hearing loss: An MRI and FDG-PET study","authors":"Ryota Sakurai,&nbsp;Yuri Kim,&nbsp;Maki Nishinakagawa,&nbsp;Keigo Hinakura,&nbsp;Yoshinori Fujiwara,&nbsp;Kenji Ishii","doi":"10.1111/ggi.15052","DOIUrl":"10.1111/ggi.15052","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Age-related hearing loss (ARHL) is a common problem among older adults and contributes to adverse health outcomes such as cognitive impairment. However, the neural mechanisms underlying ARHL remain unclear. We aimed to reveal the structural and metabolic (i.e., neural activity) correlates of ARHL using magnetic resonance imaging (MRI) and positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 162 community-dwelling older adults without cerebral disorders or cognitive impairment (Mini-Mental State Examination score &lt; 24) were included in this study. Auditory acuity was measured using a pure-tone average (PTA) of hearing thresholds for the better-hearing ear for 0.5–4-kHz tones. ARHL was defined as a PTA of &gt;40 dB (i.e., greater than moderate hearing loss). The participants then underwent MRI and FDG-PET at rest to assess changes in brain structure and activity associated with ARHL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 162 participants, 27 (16.6%) had ARHL. A region-of-interest analysis focusing on the bilateral superior temporal gyrus showed significantly lower glucose metabolism in this region, including in the auditory cortex (BA 41 and 42), in participants with ARHL than in those without ARHL. In contrast, no significant structural differences were observed between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that, prior to structural changes, the effects of ARHL may manifest in neural activity, which is strongly reflected in the regions involved in auditory processing. It is possible that ARHL first alters neural activity in auditory-related regions owing to reduced auditory stimulation. <b>Geriatr Gerontol Int 2025; 25: 300–306</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"300-306"},"PeriodicalIF":2.4,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional disparities in home health care utilization for older adults and their associated factors at the secondary medical area level: A nationwide study in Japan” [Letter]","authors":"Sari Luthfiyah,&nbsp;Wannarat Lawang,&nbsp;Fathimath Shifaza","doi":"10.1111/ggi.15069","DOIUrl":"10.1111/ggi.15069","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"329-330"},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in biomarkers for senescence: Bridging basic research to clinic","authors":"Takeshi Fukumoto,&nbsp;Tatsuo Shimosawa,&nbsp;Mitsutaka Yakabe,&nbsp;Shota Yoshida,&nbsp;Yohko Yoshida","doi":"10.1111/ggi.15054","DOIUrl":"10.1111/ggi.15054","url":null,"abstract":"<p>In this review, we review the current status of biomarkers for aging and possible perspectives on anti-aging or rejuvenation from the standpoint of biomarkers. Aging is observed in all cells and organs, and we focused on research into senescence in the skin, musculoskeletal system, immune system, and cardiovascular system. Commonly used biomarkers include SA-βgal, cell-cycle markers, senescence-associated secretory phenotype (SASP) factors, damage-associated molecular patterns (DAMPs), and DNA-damage-related markers. In addition, each organ or cell has its specific markers. Generally speaking, a combination of biomarkers is required to define age-related changes. When considering the translation of basic research, biomarkers that are highly sensitive, highly specific, with validation and reliability as well as being non-invasive are optimal; however, currently reported markers do not fulfill the prerequisite for biomarkers. In addition, rodent models of aging do not necessarily represent human aging, and markers in rodent or cell models are not applicable in clinical settings. The prerequisite of clinically applicable biomarkers is that they provide useful information for clinical decision-making, such as predicting disease risk, diagnosing disease, monitoring disease progression, or guiding treatment decisions. Therefore, the development of non-invasive robust, reliable, and useful biomarkers in humans is necessary to develop anti-aging therapy for humans. <b>Geriatr Gerontol Int 2025; 25: 139–147</b>.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"139-147"},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Frailty as a predictor of mortality in the oldest old: A systematic review and meta-analysis”","authors":"Shubham Kumar,&nbsp;Ahmad Neyazi,&nbsp;Rachana Mehta,&nbsp;Ranjana Sah","doi":"10.1111/ggi.15065","DOIUrl":"10.1111/ggi.15065","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"328-329"},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet-related quality of life may directly and indirectly affect health-related quality of life through protein intake and frailty in patients with osteoporosis: Results from a prospective cohort study","authors":"Yoshinari Matsumoto,&nbsp;Chie Wakano,&nbsp;Takashi Kimura,&nbsp;Eri Nishioka,&nbsp;Nana Yunoki,&nbsp;Masao Kurokawa","doi":"10.1111/ggi.15067","DOIUrl":"10.1111/ggi.15067","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We aimed to examine the direct and indirect associations between diet-related quality of life (DRQOL) and health-related quality of life (HRQOL) in patients with osteoporosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional and longitudinal analyses were conducted using data from a 1-year prospective cohort survey of 532 consecutive patients with osteoporosis. The DRQOL was assessed using a short version of the Diet-Related Quality of Life Scale. Dietary intake statuses were assessed using the brief-type self-administered diet history questionnaire. Frailty was assessed using the Kihon Checklist (KCL). HRQOL was assessed using the EuroQol 5-dimensions 5-level (EQ-5D-5L) score. The association between the DRQOL scores and each item was analyzed using multivariable logistic regression, path analysis, and a cross-lagged panel model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the baseline cross-sectional analysis, DRQOL scores at the ≥75th percentile of the cohort were associated with protein intake (odds ratio [OR] 2.18; 95% confidence intervals [CIs]: 1.20, 3.96), frailty (OR: 0.14; 95% CIs: 0.06, 0.33), and having a full EQ-5D-5L score (OR: 2.37; 95% CIs: 1.33, 4.21). In the path analysis, the DRQOL score was directly related to the EQ-5D-5L score and indirectly related via protein intake and the KCL score (standardized direct effect: 0.08, standardized indirect effect: 0.11). In the cross-lagged panel model, DRQOL scores at baseline were indirectly positively associated with EQ-5D-5L scores at 1 year (standardized direct effect: −0.06, standardized indirect effect: 0.23).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The DRQOL in patients with osteoporosis may be directly and indirectly related to the HRQOL via protein intake and frailty. <b>Geriatr Gerontol Int 2025; 25: 243–250</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"243-250"},"PeriodicalIF":2.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-stroke patient characteristics that influence skeletal muscle quality: A cross-sectional study","authors":"Keisuke Honma,&nbsp;Yosuke Honda,&nbsp;Masahiro Nagase,&nbsp;Yuta Nakao,&nbsp;Koichiro Sota,&nbsp;Naoki Sasanuma,&nbsp;Masataka Igeta,&nbsp;Yuki Uchiyama,&nbsp;Kazuhisa Domen","doi":"10.1111/ggi.15060","DOIUrl":"10.1111/ggi.15060","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>One of the parameters that is measurable using bioelectrical impedance is the phase angle (PhA), which is an indicator of skeletal muscle quality. The PhA reflects cellular health and nutritional status and is an important parameter for monitoring recovery after stroke. However, the factors affecting skeletal muscle quality remain unclear. Therefore, this study aimed to identify the factors associated with skeletal muscle quality in patients with acute stroke.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 505 consecutively hospitalized patients with acute stroke were included in this study. The primary outcome was the PhA measured by bioelectrical impedance analysis, which evaluates muscle quality. Multiple regression analysis was performed to identify the factors affecting PhA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of the participants was 75.1 years, and 44% were female. The median National Institutes of Health Stroke Scale (NIHSS) score upon admission was 4, and the mean length of stay was 18 days. The mean PhA for skeletal muscle quality was 4.9° in males and 3.9° in females. Multiple regression analysis showed that age, sex, pre-stroke modified Rankin Scale (pre-mRS), Geriatric Nutritional Risk Index, type 2 diabetes mellitus, atrial fibrillation, and chronic kidney disease had independent effects on PhA (<i>R</i>² = 0.575; <i>P</i> = 0.001). Age, pre-mRS, NIHSS, dementia, and PhA independently associated with functional independence measure at discharge (<i>R</i>² = 0.657; <i>P</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study identified determinants contributing to the deterioration of muscle quality upon admission in acute stroke patients. Further investigation is needed to ascertain whether modulation of these factors improves muscle quality. <b>Geriatr Gerontol Int 2025; 25: 213–219</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"213-219"},"PeriodicalIF":2.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cardiorespiratory fitness and falls in older adults: A population-based study","authors":"Julia Araujo de Figueiredo,&nbsp;Magno Conceição Garcia,&nbsp;Aldair J Oliveira","doi":"10.1111/ggi.15036","DOIUrl":"10.1111/ggi.15036","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The present study investigated the relationship between cardiorespiratory fitness (CRF) and episodes and severity of falls in older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study drew on data from the Brazilian 2019 National Health Survey. The sample consisted of 18 991 older adults (aged ≥60 years). CRF was obtained through a non-exercise model for estimating VO_2max, and the people were classified as low, moderate or high CRF. Logistic and multinomial regression models were used. Odds ratios (ORs) and their respective confidence intervals (95% CIs) were calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Older adults with strong CRF are 29% (OR 0.69, 95% CI 0.52–0.92) less likely to suffer falls than those with poor CRF. High levels of CRF were also associated with non-severe falls. However, no associations were found between CRF and severe falls with fractures and medical intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although good CRF levels can reduce the chance of falls, this protection does not extend to falls with more severe consequences, such as fractures and the need to seek medical care. <b>Geriatr Gerontol Int 2025; 25: 167–172</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"167-172"},"PeriodicalIF":2.4,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study","authors":"Orhan Cicek,&nbsp;Mehtap Onal,&nbsp;Mustafa Hakan Dogan,&nbsp;Ilyas Akkar,&nbsp;Zeynep Iclal Turgut,&nbsp;Merve Yilmaz Kars,&nbsp;Muhammet Cemal Kizilarslanoglu","doi":"10.1111/ggi.15051","DOIUrl":"10.1111/ggi.15051","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"327-328"},"PeriodicalIF":2.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of exercise and dietary habits on the association of alpha-actinin-3 gene polymorphisms with physical function and body composition in community-dwelling individuals aged 60 years and older","authors":"Daijo Shiratsuchi,&nbsp;Yoshiaki Taniguchi,&nbsp;Shoma Akaida,&nbsp;Mana Tateishi,&nbsp;Yuto Kiuchi,&nbsp;Ryota Kuratsu,&nbsp;Hyuma Makizako","doi":"10.1111/ggi.15042","DOIUrl":"10.1111/ggi.15042","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Alpha-actinin 3 (<i>ACTN3</i>) is associated with diminished physical function and muscle mass in older individuals. However, the effects of lifestyle on this relationship remain unclear. This study explored whether the association between <i>ACTN3</i> polymorphisms and physical function and body composition varied based on exercise and dietary habits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A longitudinal analysis of 197 community-dwelling individuals aged 60 years and older (mean age 72.5 ± 5.9 years, 60.9% women) in the Tarumizu study provided data on <i>ACTN3</i> gene polymorphisms, with surveys completed in 2019 and 2022 (mean follow-up 1156 ± 80.0 days). Physical performance (grip strength, walking speed) and body composition (body weight, appendicular skeletal muscle mass [ASMM], and fat mass) were assessed. Genetic polymorphisms were analyzed in oral mucosa samples and categorized into type R allele carriers and type XX alleles (homozygous for minor alleles). Median values determined exercise habits (≤4 days/week or ≥5 days/week) and dietary habits based on high-protein-food frequency scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proportion of type XX genetic polymorphism was 26.4%. Two-way repeated-measures analysis of covariance showed a significant interaction between genetic polymorphism and time for ASMM (<i>F</i> = 10.552, <i>P</i> = 0.002) in the ≤4 days/week exercise habits group. Significant interactions were observed in grip strength (<i>F</i> = 7.013, <i>P</i> = 0.009) and ASMM (<i>F</i> = 5.347, <i>P</i> = 0.023) for the ≤11 score high-protein-intake group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This association may contribute to accelerated age-related changes in physical performance and body composition, particularly among individuals with type XX genetic polymorphism who have low exercise habits and a limited intake of high-protein foods. <b>Geriatr Gerontol Int 2025; 25: 173–181</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 2","pages":"173-181"},"PeriodicalIF":2.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.15042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}