Geriatrics & Gerontology International最新文献

{"title":"Glucocorticoid usage is involved in the improvement and development of frailty in patients with rheumatoid arthritis: Results from the PRESENT study","authors":"Masahiro Tada,&nbsp;Yoshinari Matsumoto,&nbsp;Tatsuya Koike,&nbsp;Kenji Mamoto,&nbsp;Tomoyuki Nakamura,&nbsp;Shohei Anno,&nbsp;Takahiro Iida,&nbsp;Hitoshi Goto,&nbsp;Masanori Matsuura","doi":"10.1111/ggi.70137","DOIUrl":"10.1111/ggi.70137","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This longitudinal cohort study examined the development and improvement of frailty. We analyzed baseline factors and 1-year changes to identify ways to prevent frailty and preserve quality of life in patients with rheumatoid arthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 160 patients with rheumatoid arthritis from the multicenter, prospective prospective observational cohort study were analyzed over a 1 year. Among the 104 robust or prefrail patients at baseline, those who progressed to frailty were classified as frailty development, whereas those who remained robust or prefrail were frailty undiagnosed. Among the 56 frail patients, those with improved frailty were classified as frailty improvement, and those who remained frail were classified as frailty continuation. The correlations between frailty development and improvement, baseline factors, and parameter changes were examined using univariate and multivariate logistic regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 94 (90.4%) patients were frailty undiagnosed, and 10 (9.6%) were frailty development. Glucocorticoid usage (OR 6.21) and changes in the modified Health Assessment Questionnaire (ΔmHAQ; OR 1.49) were identified as a significant factor for frailty development adjusted for age, sex, disease activity score composite of the ESR and the 28-joint score, biological/targeted synthetic disease-modifying anti-rheumatic drug usage and mHAQ at baseline. A total of 28 (50.0%) patients were in the frailty continuation group, whereas 28 (50.0%) patients belonged were in the frailty improvement group. Glucocorticoid usage (OR 0.23) and ΔmHAQ (OR 0.75) were identified as significant factors for frailty improvement adjusted for age, sex, disease activity score composite of the ESR and the 28-joint score, biological/targeted synthetic disease-modifying anti-rheumatic drug usage, and mHAQ at baseline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Avoiding glucocorticoid use and improvement of quality of life are key to preventing and overcoming frailty in patients with rheumatoid arthritis, and potentially extending their life expectancy. <b>Geriatr Gerontol Int 2025; 25: 1231–1238</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1231-1238"},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and preliminary effects of a cognitive intervention program using the Pair Go game: A pilot study","authors":"Ai Iizuka,&nbsp;Hisao Taki,&nbsp;Kenji Toba,&nbsp;Hiroyuki Suzuki","doi":"10.1111/ggi.70134","DOIUrl":"10.1111/ggi.70134","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Go, a strategic board game, has demonstrated effectiveness in enhancing cognitive functions such as visual working memory. However, individuals who play Go often find it difficult to expand their social network through playing and do not like losing. This study aimed to develop a cognitive intervention program utilizing Pair Go, a variant of Go played in pairs, to foster greater social interaction and it conducted preliminary assessments on the feasibility of the program and its impact on cognitive function and mental health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-three community-dwelling older adults, none of whom had prior experience with Go, attended 12 sessions of the Pair Go program once a week for 90 min per session. The feasibility of the program was evaluated using measures of attendance rate, program satisfaction, and willingness to continue participating in the Pair Go program. In addition, cognitive function and mental health assessments were conducted before and after the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both the attendance rate and the program satisfaction were high, and all participants expressed a desire to continue engaging in Pair Go. Comparison of pre- and post-test scores using paired <i>t</i>-tests revealed significant improvements in executive function, attention, and memory (all <i>P</i> &lt; 0.05). Moreover, there was a significant decrease in feelings of loneliness in the post-test score (<i>P</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results indicate that this program is feasible and has preliminary effects on cognitive function and mental health. <b>Geriatr Gerontol Int 2025; 25: 1209–1214</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1209-1214"},"PeriodicalIF":2.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering multimorbidity patterns linked to disability in aging populations: A machine learning analysis","authors":"Zhijun He,&nbsp;Xingtong Pei,&nbsp;Xiaofeng Li,&nbsp;Yang Zhao,&nbsp;Mingming Xu","doi":"10.1111/ggi.70128","DOIUrl":"10.1111/ggi.70128","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Multimorbidity and disability are prevalent in older adults, yet the relationship between specific multimorbidity patterns and disability is poorly understood. This study aimed to identify clinically significant multimorbidity patterns in older adults and assess their impact on disability levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from a cross-sectional survey of individuals aged 60 and above in China. A machine learning approach combining the self-organizing maps and K-means clustering was employed to identify multimorbidity patterns. Ordered logistic regression was used to analyze the association between multimorbidity patterns and disability levels. Three-dimensional surface modeling was applied to visualize the heterogeneity of multimorbidity patterns and disability levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Considering all the respondents, a total of 10 multimorbidity patterns were identified, each named after the two diseases with the highest prevalence. Older adults with multimorbidity were at greater risk for higher disability levels compared with those without multimorbidity (odds ratio [OR] = 1.679, <i>P</i> &lt; 0.001). Among the identified multimorbidity patterns, the Allomnesia-Arthritis pattern exhibited the highest risk of more severe disability (OR = 3.976, <i>P</i> &lt; 0.001), followed by the Hypertension-Stroke pattern (OR = 3.745, <i>P</i> &lt; 0.001). Heterogeneity analysis revealed that multimorbidity–disability combinations differed across demographic factors, including age, education, and income levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study underscores the significant impact of specific multimorbidity patterns on disability levels in older adults. The application of machine learning techniques offers a more nuanced understanding of how various disease combinations contribute to disability, highlighting the importance of tailored interventions for managing multimorbidity in aging populations. <b>Geriatr Gerontol Int 2025; 25: 1200–1208</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1200-1208"},"PeriodicalIF":2.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidomain interventions for dementia: Reconsidering clinical relevance, transferability and trial limitations","authors":"Hanadi Al Hamad,&nbsp;Brijesh Sathian","doi":"10.1111/ggi.70131","DOIUrl":"10.1111/ggi.70131","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 10","pages":"1436-1437"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Beyond the gut: The overlooked impact of constipation on functional mobility and quality of life in community-dwelling elders: A cross-sectional study”","authors":"Liang Liu,&nbsp;Yiheng Yao","doi":"10.1111/ggi.70125","DOIUrl":"10.1111/ggi.70125","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1288-1289"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrailty prevalence and all-cause mortality risk in older adults from the general population: A meta-analysis of prospective cohort studies","authors":"Li Yu,&nbsp;Xuan Tang,&nbsp;Dandan Gong,&nbsp;Changfeng Man,&nbsp;Yu Fan","doi":"10.1111/ggi.70133","DOIUrl":"10.1111/ggi.70133","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Prefrailty represents an intermediate stage between robust health and frailty. This meta-analysis aimed to estimate the global prevalence of prefrailty and evaluate its association with all-cause mortality in older adults from the general population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two independent reviewers systematically searched PubMed, Web of Science, and Embase for relevant studies published through to December 10, 2024. Eligible studies reported either prefrailty prevalence or all-cause mortality risk in older adults from the general population aged 65 years and older.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis included 26 studies (25 articles; <i>N</i> = 222 473). The included studies utilized the Fried frailty phenotype and frailty index to define prefrailty. The pooled prefrailty prevalence was 45% (95% confidence interval [CI] 42–48%), with similar rates across assessment methods. Prefrailty significantly increased all-cause mortality risk (hazard ratio [HR] 1.38; 95% CI 1.32–1.45). Sex-specific analyses showed a marginally higher risk in men (HR 1.39; 95% CI 1.30–1.49) than in women (HR 1.33; 95% CI 1.25–1.41). Mortality associations were stronger when prefrailty was defined by the frailty index (HR 1.47; 95% CI 1.35–1.61) than by phenotype (HR 1.37; 95% CI 1.32–1.42).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Nearly half of older adults exhibit prefrailty, which confers a 38% increased mortality risk in older adults from the general population. These findings underscore the need for early identification and intervention in this high-risk subgroup. <b>Geriatr Gerontol Int 2025; 25: 1167–1177</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1167-1177"},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-development of frailty and functional ability in older adults: A parallel-process latent growth curve model","authors":"Jiaqi Yu,&nbsp;Linhan Wang,&nbsp;Ziyi Wang,&nbsp;Shuyu Chen,&nbsp;Yanyan Li,&nbsp;Wendie Zhou,&nbsp;Cuili Wang","doi":"10.1111/ggi.70136","DOIUrl":"10.1111/ggi.70136","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore the co-development and possible risk factors of frailty and functional ability among community-dwelling older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This secondary analysis used data from a prospective three-wave cohort study with a sample of 780 older adults. Frailty was assessed using the Tilburg Frailty Indicator, and functional ability using the Lawton Instrumental Activities of Daily Living Scale. A conditional parallel-process latent growth curve model was implemented to test their dynamic relationship and explore the potential risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Frailty and functional ability significantly deteriorated over 3 years. Older adults with severer frailty were more likely to experience poor initial functional ability as well as a faster loss of functional ability, and a rapid functional ability decline was more easily observed in participants suffering an accelerating increase in frailty deterioration. Furthermore, lack of a spouse and the presence of comorbidities were significantly related to severer initial frailty, while lower educational attainment was associated with poorer baseline functional ability. Advanced age impaired initial functional ability and accelerated its rate of deterioration over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Frailty and functional ability significantly deteriorated over a 3-year period, and the frailty trajectory significantly affected the evolution of functional ability. In addition, age, marital status, educational level, and multimorbidity were significant risk factors. These results underscore the importance of timely and tailored approaches addressing frailty and risk factors for maintaining functional ability and promoting healthy aging among community-dwelling older populations. <b>Geriatr Gerontol Int 2025; 25: 1223–1230</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1223-1230"},"PeriodicalIF":2.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Werner syndrome due to homozygous WRN mutation through chromosome 8 region of homozygosity in a consanguineous family","authors":"Siruo Liu,&nbsp;Xiaoli Wang,&nbsp;Xiaojuan Zhao","doi":"10.1111/ggi.70130","DOIUrl":"10.1111/ggi.70130","url":null,"abstract":"<p>An 18-year-old man showing growth retardation, progeroid facies and acral abnormalities was found to have Werner syndrome caused by a homozygous <i>WRN</i> mutation (c.502_503del) located within a 36.7-Mb region of homozygosity on chromosome 8.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1271-1272"},"PeriodicalIF":2.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of socioeconomic status with arts and cultural engagement among older adults in Japan","authors":"Taiji Noguchi,&nbsp;Erhua Shang,&nbsp;Takahiro Hayashi","doi":"10.1111/ggi.70129","DOIUrl":"10.1111/ggi.70129","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1276-1281"},"PeriodicalIF":2.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the maximal respiratory pressure and peak expiratory flow rate in diagnosing probable respiratory sarcopenia – The Otassha Study","authors":"Takeshi Kera,&nbsp;Hisashi Kawai,&nbsp;Manami Ejiri,&nbsp;Keigo Imamura,&nbsp;Hirohiko Hirano,&nbsp;Yoshinori Fujiwara,&nbsp;Kazushige Ihara,&nbsp;Shuichi Obuchi","doi":"10.1111/ggi.70124","DOIUrl":"10.1111/ggi.70124","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The availability of diverse assessment methods, based on different devices and conditions, for respiratory sarcopenia is crucial for developing community health initiatives. Thus, in this study, we aimed to compare the concordance in diagnosing respiratory sarcopenia based on the maximal respiratory pressure (MRP) and peak expiratory flow rate (PEFR), which are specific indicators of respiratory-muscle strength, in a community-dwelling older adult population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In the Otassha Study conducted in 2023, 499 community-dwelling adults aged &gt;65 years in Itabashi Ward (184 men and 315 women) were evaluated for MRP, PEFR, walking speed, grip strength, and appendicular skeletal muscle mass (ASM). We determined two respiratory-sarcopenia models using low skeletal muscle mass and low MRP/PEFR (both &lt;80% for predicted values). Pearson correlation coefficients were used to compare each measurement; the agreement between respiratory sarcopenia diagnosed using low MRP and PEFR was evaluated using kappa coefficients (κ).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PEFR was correlated with MRP (maximal expiratory pressure: <i>r</i> = 0.415; maximal inspiratory pressure: <i>r</i> = 0.380; <i>P</i> &lt; 0.01, respectively). A moderate level of agreement was found between respiratory sarcopenia diagnosed using MRP and that diagnosed using PEFR (κ = 0.597, match rate = 87.2%), suggesting a fair consistency level between the methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although PEFR had a moderate correlation with MRP, the concordance of respiratory sarcopenia diagnosed using the two methods was moderate, suggesting that the two approaches are partially interchangeable and are complementary. The findings showed that PEFR, proposed as an alternative to MRP, is valid for diagnosing respiratory sarcopenia, supporting its role as an alternative to the gold standard for evaluating respiratory-muscle strength. <b>Geriatr Gerontol Int 2025; 25: 1253–1259</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 9","pages":"1253-1259"},"PeriodicalIF":2.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}