{"title":"Comment on “Loneliness and isolation: Are they associated with the wish for an earlier end of life?”","authors":"Chang Hu","doi":"10.1111/ggi.70165","DOIUrl":"10.1111/ggi.70165","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 10","pages":"1454-1455"},"PeriodicalIF":2.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between plasma mid-regional pro-adrenomedullin levels and muscle properties","authors":"Hiroshi Akasaka, Yasuharu Tabara, Kazuki Fukuma, Yoshihisa Hiromine, Yasunori Takata, Masahiro Fukuda, Tomohiro Katsuya, Masafumi Ihara, Haruhiko Osawa, Hiroshi Ikegami, Michiya Igase, Hiromi Rakugi, Ken Sugimoto","doi":"10.1111/ggi.70155","DOIUrl":"10.1111/ggi.70155","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Adrenomedullin exerts a vasodilative effect and is thought to be associated with skeletal muscle properties by regulating microcirculation. This cross-sectional study aimed to clarify the possible association in older adults aged ≥65 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study population included 978 community residents (mean age 71.5 years) who participated in the medical checkup. Mid-thigh skeletal muscle mass and fat infiltration into the muscle was assessed using computed tomography images. Plasma levels of mid-regional pro-adrenomedullin, a stable fragment derived from pro-adrenomedullin in a 1:1 ratio with adrenomedullin, were measured using blood drawn at the medical checkup, and quartiles were calculated for analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mid-regional pro-adrenomedullin did not show significant association with the mid-thigh skeletal muscle cross-sectional area, an index of muscle mass (Q1: 217 ± 50, Q2: 218 ± 48, Q3: 215 ± 48, Q4: 212 ± 45 cm<sup>2</sup>, <i>P</i> = 0.544). Muscle subtype analysis showed that mid-regional pro-adrenomedullin was inversely associated with fewer fat (high intensity) muscle areas and positively associated with fat-rich (low intensity) muscle areas, resulting in an inverse association with mean muscle intensity, an index of muscle quality (Q1: 50.3 ± 4.2, Q2: 49.6 ± 4.5, Q3: 49.1 ± 4.3, Q4: 47.1 ± 4.6 HU, <i>P</i> < 0.001). This association remained significant after adjustment of possible covariates, including anthropometric factors and glycemic factors (Q1: reference, Q2: β = −0.078, <i>P</i> = 0.018, Q3: β = −0.099, <i>P</i> = 0.004, Q4: β = −0.180, <i>P</i> < 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adrenomedullin is associated with muscle quality, but not with muscle mass. <b>Geriatr Gerontol Int 2025; 25: 1418–1424</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 10","pages":"1418-1424"},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cross-sectional relationship between social trust and health in middle-aged and older Chinese adults: Can social trust explain the education–health link?","authors":"Tingting Yang, Xueying Zhu, Yongqi Wang, Yu Tang, Xiaojun Tang, Baowen Xue, Xianbin Ding, Yaoyue Hu","doi":"10.1111/ggi.70154","DOIUrl":"10.1111/ggi.70154","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Evidence on the association of social trust with health in middle-aged and older Chinese adults is limited, and its mediating role in the education–health link remains unclear. This study investigated the association of social trust with chronic diseases and mental health, and its mediating effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional data came from the 2018–2019 baseline survey of the Chongqing Cohort of the China Multi-Ethnic Cohort study, including 15 251 participants aged ≥45 years, with data collected using questionnaires and physical examinations. Logistic regression and serial multiple mediation models were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Low social trust was associated with higher risks of dyslipidemia (odds ratio [OR] 1.30, 95% confidence interval [CI] 1.07, 1.56), stroke (OR 2.60, 95% CI 1.26, 5.33) and kidney disease (OR 2.44, 95% CI 1.30, 4.57). A gradient in the risk of anxiety (high social trust: OR 1.38, 95% CI 1.05, 1.81; medium: OR 2.26, 95% CI 1.69, 3.02; low: OR 2.76, 95% CI 1.91, 3.99, compared with very high) and depression (medium: OR 1.67, 95% CI 1.26, 2.20; low: OR 1.74, 95% CI 1.19, 2.56) was identified. The serial mediation analysis found no mediation of social trust on the relationships between education and chronic diseases, but only an indirect effect of household income for impaired lung and liver function. Social trust mediated the relationships between education and anxiety and depression, with small effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Social trust is associated with certain chronic conditions and mental health. Alongside household income, it mediates the relationship between education and mental health, implying that enhancing social trust could be an effective strategy for improving mental health. <b>Geriatr Gerontol Int 2025; 25: 1359–1369</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 10","pages":"1359-1369"},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “Enhancing emergency care for geriatric patients: Insights from a dedicated outpatient clinic study”","authors":"Zilin Zhao, Yifan Qi, Hejia Wan","doi":"10.1111/ggi.70163","DOIUrl":"10.1111/ggi.70163","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 10","pages":"1452-1453"},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Independent and joint associations of vision and hearing impairments with arthritis: Findings from a population-based study","authors":"Xue Wang, Huaxin Si, Yanyan Li, Jiaqi Yu, Wendie Zhou, Hejing Chen, Cuili Wang","doi":"10.1111/ggi.70156","DOIUrl":"10.1111/ggi.70156","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Sensory impairments (SIs), encompassing both vision impairment (VI) and hearing impairment (HI), frequently co-occur in middle-aged and older adults and are linked to various neurodegenerative conditions. This study aimed to explore both the independent and joint associations of VI and HI with the prevalence and incidence of arthritis in this population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 17 154 individuals were included in the cross-sectional analysis, with 6946 having 10-year longitudinal data available. We assessed the cross-sectional association of VI and HI with prevalent arthritis using logistic regression and analyzed the longitudinal association with incident arthritis events using Cox proportional hazards models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>VI and HI were both associated with a higher likelihood of prevalent arthritis (VI: odds ratio [OR], 1.64; 95% confidence interval [CI], 1.49–1.81; HI: OR, 1.44; 95% CI, 1.34–1.56). Compared with those with no SI, those with VI only (OR, 1.58; 95% CI, 1.39–1.80), HI only (OR, 1.50; 95% CI, 1.39–1.80), and dual sensory impairment (DSI) (OR, 2.03; 95% CI, 1.80–2.29) had a higher risk of prevalent arthritis. Individuals with VI (hazard ratio [HR], 1.13; 95% CI, 1.01–1.26) or HI (HR, 1.20; 95% CI, 1.09–1.32) had increased risk of incident arthritis, with those having DSI at the highest risk (HR, 1.25; 95% CI, 1.10–1.43).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings highlight the importance of incorporating vision and hearing screenings into routine health check-ups, as early identification of impairments could significantly enhance the effectiveness of arthritis prevention strategies. <b>Geriatr Gerontol Int 2025; 25: 1370–1378</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 10","pages":"1370-1378"},"PeriodicalIF":2.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144949541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Balamrit Singh Sokhal, Andrija Matetić, Joanne Protheroe, Toby Helliwell, Phyo K. Myint, Timir K. Paul, Christian D. Mallen, Mamas A. Mamas
{"title":"Emergency department attendance stratified by cause and frailty status: A national retrospective cohort study","authors":"Balamrit Singh Sokhal, Andrija Matetić, Joanne Protheroe, Toby Helliwell, Phyo K. Myint, Timir K. Paul, Christian D. Mallen, Mamas A. Mamas","doi":"10.1111/ggi.70153","DOIUrl":"10.1111/ggi.70153","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to determine whether the causes of emergency department (ED) attendance and clinical outcomes vary by frailty status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using the Nationwide ED Sample, causes of attendance were stratified by Hospital Frailty Risk Score (HFRS). Logistic regression was used to determine adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) of ED and overall mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 155 497 048 ED attendances were included, of which 125 809 960 (80.9%) had a low HFRS (<5), 27 205 257 (17.5%) had an intermediate HFRS (5–15), and 2 481 831 (1.6%) had a high HFRS (>15). The most common cause of ED attendance in the high-HFRS group was infectious diseases (43.0%), followed by cardiovascular diseases (CVD) (24.0%) and respiratory diseases (10.2%). For the low-HFRS group, musculoskeletal disease was the most common cause (21.2%), followed by respiratory diseases (20.6%) and gastrointestinal diseases (18.5%). On adjusted analysis, high-HFRS attendances had increased overall mortality (combined ED and in-hospital) across most attendance causes, compared with their low-risk counterparts (<i>P</i> < 0.001). High-HFRS attendances with infectious diseases, CVD, and respiratory diseases had an increased risk of overall mortality, compared with their low-risk counterparts (aOR 23.88, 95% CI 23.42–24.34 for the infectious disease cohort; aOR 2.58, 95% CI 2.55–2.61 for the CVD cohort; and aOR 36.90, 95% CI 36.18–37.62 for the respiratory disease cohort).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Frailty is present in a significant proportion of ED attendances, with the cause varying by frailty status. Frailty is associated with decreased ED and increased overall mortality across most attendance causes. <b>Geriatr Gerontol Int 2025; 25: 1350–1358</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 10","pages":"1350-1358"},"PeriodicalIF":2.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.70153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}