Frontiers in Human Neuroscience最新文献

{"title":"Brain plasticity associated with prolonged shooting training: a multimodal neuroimaging investigation from a cross-sectional study.","authors":"Keying Zhang, Tao Zhao, Yu Ding, Jia Cheng, Chunmei Cao","doi":"10.3389/fnhum.2025.1530642","DOIUrl":"10.3389/fnhum.2025.1530642","url":null,"abstract":"<p><strong>Background: </strong>Although training has been recognized as a potential contributor to neuroplasticity in athletes, the impact of prolonged shooting training on human brain plasticity remains unclear in the existing literature.</p><p><strong>Methods: </strong>In this cross-sectional study, we used a multimodal neuroimaging analysis, including the analysis of functional blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) images, structural T1-weighted MRI images, and diffusion MRI images, to systematically identify differences between elite shooters and normal controls.</p><p><strong>Results: </strong>The results showed that compared to male normal controls, male elite shooters had higher regional homogeneity (ReHo) in the frontal lobe, parietal lobe, precuneus, thalamus, and cingulate gyrus, as well as higher functional connectivity between the medial frontal cortex (MedFC) and temporooccipital middle temporal gyrus (toMTG). Male elite shooters also showed higher cortical thickness in the right inferior temporal lobe; lower fractional anisotropy (FA) values in the right superior longitudinal fasciculus (SLF), right inferior fronto-occipital fasciculus (IFF), and right anterior thalamic radiation (ATR); lower axial diffusivity (AD) value in forceps minor and left ATR; and lower structural connectivity between right putamen and right inferior parietal cortex (IPC), right IPC and right paracentral cortex, and right paracentral cortex and right superior parietal cortex (SPC).</p><p><strong>Conclusion: </strong>Elite male shooters exhibited optimized resting-state functional activity, functional connectivity, and morphological features compared to normal controls. Prolonged shooting training may contribute to enhancing the brain's functional and structural plasticity related to motor control, attentional focus, and emotion regulation in male shooters; however, similar changes have not been observed in female shooters.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1530642"},"PeriodicalIF":2.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11860876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Women in cognitive neuroscience: 2023.","authors":"Valentina Bruno, Rania A Mekary","doi":"10.3389/fnhum.2025.1560661","DOIUrl":"10.3389/fnhum.2025.1560661","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1560661"},"PeriodicalIF":2.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel paradigm for fast training data generation in asynchronous movement-based BCIs.","authors":"Markus R Crell, Kyriaki Kostoglou, Kathrin Sterk, Gernot R Müller-Putz","doi":"10.3389/fnhum.2025.1540155","DOIUrl":"10.3389/fnhum.2025.1540155","url":null,"abstract":"<p><strong>Introduction: </strong>Movement-based brain-computer interfaces (BCIs) utilize brain activity generated during executed or attempted movement to provide control over applications. By relying on natural movement processes, these BCIs offer a more intuitive control compared to other BCI systems. However, non-invasive movement-based BCIs utilizing electroencephalographic (EEG) signals usually require large amounts of training data to achieve suitable accuracy in the detection of movement intent. Additionally, patients with movement impairments require cue-based paradigms to indicate the start of a movement-related task. Such paradigms tend to introduce long delays between trials, thereby extending training times. To address this, we propose a novel experimental paradigm that enables the collection of 300 cued movement trials in 18 min.</p><p><strong>Methods: </strong>By obtaining measurements from ten participants, we demonstrate that the data produced by this paradigm exhibits characteristics similar to those observed during self-paced movement.</p><p><strong>Results and discussion: </strong>We also show that classifiers trained on this data can be used to accurately detect executed movements with an average true positive rate of 31.8% at a maximum rate of 1.0 false positives per minute.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1540155"},"PeriodicalIF":2.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice.","authors":"Henry Tan, Devon J Griggs, Lucas Chen, Kahte Adele Culevski, Kathryn Floerchinger, Alissa Phutirat, Gabe Koh, Nels Schimek, Pierre D Mourad","doi":"10.3389/fnhum.2024.1509432","DOIUrl":"10.3389/fnhum.2024.1509432","url":null,"abstract":"<p><p>Transcranially delivered diagnostic ultrasound (tDUS) applied to the human brain can modulate those brains such that they became more receptive to external stimulation relative to sham ultrasound exposure. Here, we sought to directly measure the effect of tDUS on mouse brain activity subjected to an external stimulation-a blinking light. Using electrocorticography, we observed a substantial increase in median brain activity due to tDUS plus a blinking light relative to baseline and relative to sham tDUS plus a blinking light. Subsequent brain activity decreased after cessation of tDUS but with continuation of the blinking light, though it remained above that demonstrated by mice exposed to only a blinking light. In a separate experiment, we showed that tDUS alone, without a blinking light, had no observable effect on median brain activity, but upon its cessation, brain activity decreased. These results demonstrate that <i>simultaneous</i> exposure to tDUS and blinking light can increase the receptivity of the visual cortex of mice exposed to that light, and that <i>prior</i> exposure to tDUS can reduce subsequent brain activity. In each case, these results are consistent with published data. Our results on mice echo published human results but do not directly explain them, since their test subjects received less intense diagnostic ultrasound than did our mice. Given the near ubiquity of diagnostic ultrasound systems, further progress along this line of research could one day lead to the widespread use of <i>diagnostic</i> ultrasound to intentionally modulate human brain function during exogenous stimulation.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1509432"},"PeriodicalIF":2.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective touch enhances low gamma activity during hand proprioceptive perception in children with different neurodevelopmental conditions.","authors":"Álvaro Sabater-Gárriz, José Antonio Mingorance, Francesc Mestre-Sansó, Vicent Canals, Yannick Bleyenheuft, Pedro Montoya, Inmaculada Riquelme","doi":"10.3389/fnhum.2025.1538428","DOIUrl":"10.3389/fnhum.2025.1538428","url":null,"abstract":"<p><strong>Background: </strong>Gamma wave activity in the sensorimotor cortex is a critical neural mechanism associated with proprioceptive processing, which is essential for motor coordination, balance, and spatial orientation. The modulation of gamma oscillations by different types of tactile stimuli, including affective touch, is not well understood, particularly in children with neurodevelopmental disorders such as cerebral palsy and autism spectrum disorder.</p><p><strong>Aims: </strong>This study aims to explore how affective touch influences gamma oscillatory activity and proprioceptive performance in children with typical development, cerebral palsy and autism spectrum disorders.</p><p><strong>Methods and procedures: </strong>EEG data were recorded from participants during passive wrist mobilizations under three conditions: following an affective touch stimulus, after a non-affective touch stimulus, and with no tactile stimulation. Time-frequency analysis of low gamma activity (30-45 Hz) on the left somatosensory cortex was conducted for each condition. Proprioceptive performance was assessed through participants' accuracy in identifying wrist positions. Proprioception and pleasantness of affective and non-affective touch were also assessed.</p><p><strong>Results: </strong>Affective touch increased proprioceptive gamma power density. Children with cerebral palsy had poorer proprioception and higher brain gamma power density for processing movement than children with typical development or autism, and their proprioception worsened with non-affective touch.</p><p><strong>Conclusion and implications: </strong>These findings highlight the potential of affective touch to modulate gamma oscillatory activity and enhance proprioceptive function, particularly in children with cerebral palsy. The results underscore the importance of incorporating emotionally meaningful sensory inputs in therapeutic interventions to support proprioceptive and motor function in children with neurodevelopmental disorders.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1538428"},"PeriodicalIF":2.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing arabic dialect detection with hybrid stacked transformer models.","authors":"Hager Saleh, Abdulaziz AlMohimeed, Rasha Hassan, Mandour M Ibrahim, Saeed Hamood Alsamhi, Moatamad Refaat Hassan, Sherif Mostafa","doi":"10.3389/fnhum.2025.1498297","DOIUrl":"10.3389/fnhum.2025.1498297","url":null,"abstract":"<p><p>The rapid expansion of dialectally unique Arabic material on social media and the internet highlights how important it is to categorize dialects accurately to maximize a variety of Natural Language Processing (NLP) applications. The improvement in classification performance highlights the wider variety of linguistic variables that the model can capture, providing a reliable solution for precise Arabic dialect recognition and improving the efficacy of NLP applications. Recent advances in deep learning (DL) models have shown promise in overcoming potential challenges in identifying Arabic dialects. In this paper, we propose a novel stacking model based on two transformer models, i.e., Bert-Base-Arabertv02 and Dialectal-Arabic-XLM-R-Base, to enhance the classification of dialectal Arabic. The proposed model consists of two levels, including base models and meta-learners. In the proposed model, Level 1 generates class probabilities from two transformer models for training and testing sets, which are then used in Level 2 to train and evaluate a meta-learner. The stacking model compares various models, including long-short-term memory (LSTM), gated recurrent units (GRU), convolutional neural network (CNN), and two transformer models using different word embedding. The results show that the stacking model combination of two models archives outperformance over single-model approaches due to capturing a broader range of linguistic features, which leads to better generalization across different forms of Arabic. The proposed model is evaluated based on the performance of IADD and Shami. For Shami, the Stacking-Transformer achieves the highest performance in all rates compared to other models with 89.73 accuracy, 89.596 precision, 89.73 recall, and 89.574 F1-score. For IADD, the Stacking-Transformer achieves the highest performance in all rates compared to other models with 93.062 accuracy, 93.368 precision, 93.062 recall, and 93.184 F1 score. The improvement in classification performance highlights the wider variety of linguistic variables that the model can capture, providing a reliable solution for precise Arabic dialect recognition and improving the efficacy of NLP applications.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1498297"},"PeriodicalIF":2.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: AI and machine learning application for neurological disorders and diagnosis.","authors":"Kandala N V P S Rajesh, Venkata Mani Vakamulla, T Sunil Kumar","doi":"10.3389/fnhum.2025.1558584","DOIUrl":"10.3389/fnhum.2025.1558584","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1558584"},"PeriodicalIF":2.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study.","authors":"Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J Dibble, Braxton Morrison, Chimere L Smith, Ronald W Davis, Wenzhong Xiao","doi":"10.3389/fnhum.2025.1509346","DOIUrl":"10.3389/fnhum.2025.1509346","url":null,"abstract":"<p><p>This pilot study harnessed the power of network medicine to unravel the complex pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). By utilizing a network analysis on whole genome sequencing (WGS) data from the Severely Ill Patient Study (SIPS), we identified ME/CFS-associated proteins and delineated the corresponding network-level module, termed the SIPS disease module, together with its relevant pathways. This module demonstrated significant overlap with genes implicated in fatigue, cognitive disorders, and neurodegenerative diseases. Our pathway analysis revealed potential associations between ME/CFS and conditions such as COVID-19, Epstein-Barr virus (EBV) infection, neurodegenerative diseases, and pathways involved in cortisol synthesis and secretion, supporting the hypothesis that ME/CFS is a neuroimmune disorder. Additionally, our findings underscore a potential link between ME/CFS and estrogen signaling pathways, which may elucidate the higher prevalence of ME/CFS in females. These findings provide insights into the pathogenesis of ME/CFS from a network medicine perspective and highlight potential therapeutic targets. Further research is needed to validate these findings and explore their implications for improving diagnosis and treatment.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1509346"},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory substitution and augmentation techniques in cerebral visual impairment: a discussion of lived experiences.","authors":"Stephanie L Duesing, Katie Lane-Karnas, Sebastian James Adam Duesing, Mae Lane-Karnas, Nai Y, Arvind Chandna","doi":"10.3389/fnhum.2025.1510771","DOIUrl":"10.3389/fnhum.2025.1510771","url":null,"abstract":"<p><p>Pediatric vision loss due to cerebral visual impairment (CVI) is an urgent public health issue, demanding evidence-based (re)habilitation and educational strategies. As with other neurodiverse populations, research on CVI needs to be directly informed by the lived experiences of those affected-children, adults, and their families. In this paper, three individuals with early-onset CVI and two parents discuss sensory substitution and augmentation developed in childhood in the absence of early identification of CVI, and they detail the important impact of the empowering, professionally taught non-visual skills-such as braille, orientation and mobility training, and assistive technology-which were acquired later. Efforts to improve visual perception ability and understanding of the visual world, both effective and ineffective, were made through traditional, professionally administered vision therapy, self-taught coping strategies, and from intensive arts participation. The authors discuss the strategies they use to leverage senses other than vision to achieve their daily life, educational, social, and career goals. Nonvisual skills training effective in those with ocular blindness, though received later in life after the delayed diagnosis, proved to be indispensable for these authors' who have CVI access to all aspects of independent life. It is our hope that these personal experiences may encourage research into how traditional nonvisual skills training used for the ocularly blind, as well as sensory substitution and augmentation techniques, may be used to develop evidence-based multidisciplinary interventions; improved academic and independent life skills; multisensory educational and therapeutic interventions; and successful integration into the community for all CVIers.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1510771"},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional segregation of rostral and caudal hippocampus in associative memory.","authors":"Alicia Nunez Vorobiova, Matteo Feurra, Enea Francesco Pavone, Lennart Stieglitz, Lukas Imbach, Victoria Moiseeva, Johannes Sarnthein, Tommaso Fedele","doi":"10.3389/fnhum.2025.1509163","DOIUrl":"10.3389/fnhum.2025.1509163","url":null,"abstract":"<p><strong>Introduction: </strong>The hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the \"where,\" \"when\" and \"how\" of distinct aspects of memory processing in the hippocampus are still under debate.</p><p><strong>Methods: </strong>Here, we employed a visual associative memory task that involved encoding three levels of subjective congruence to delineate the differential involvement of the rostral and caudal portions (also referred as anterior/posterior portions) of the human hippocampus during memory encoding, recognition and associative recall.</p><p><strong>Results: </strong>Through stereo-EEG recordings in epilepsy patients we show that associative memory is reflected by rostral hippocampal activity during encoding, and caudal hippocampal activity during retrieval. In contrast, recognition memory encoding selectively activates the rostral hippocampus. The temporal dynamics of memory processing are manifested by gamma power increase, which partially overlaps with low-frequency power decrease during encoding and retrieval. Congruence levels modulate low-frequency activity prominently in the caudal hippocampus.</p><p><strong>Discussion: </strong>These findings highlight an anatomical segregation in the hippocampus in accordance with the contributions of its partitions to associative and recognition memory.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1509163"},"PeriodicalIF":2.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}