{"title":"Predictive brain activity related to auditory information is associated with performance in speech comprehension tasks in noisy environments.","authors":"Kazuhiro Okamoto, Kengo Hoyano, Yoshitomo Saiki, Tomomi Nomura, Keisuke Irie, Naoya Obama, Narihiro Kodama, Yasutaka Kobayashi","doi":"10.3389/fnhum.2024.1479810","DOIUrl":"10.3389/fnhum.2024.1479810","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding speech in noisy environments is challenging even for individuals with normal hearing, and it poses a significant challenge for those with hearing impairments or listening difficulties. There are limitations associated with the current methods of evaluating speech comprehension in such environments, especially in individuals with peripheral hearing impairments. According to the predictive coding model, speech comprehension is an active inference process that integrates sensory information through the interaction of bottom-up and top-down processing. Therefore, in this study, we aimed to examine the role of prediction in speech comprehension using an electrophysiological marker of anticipation: stimulus-preceding negativity (SPN).</p><p><strong>Methods: </strong>We measured SPN amplitude in young adults with normal hearing during a time-estimation task with auditory feedback under both quiet and noisy conditions.</p><p><strong>Results: </strong>The results showed that SPN amplitude significantly increased in noisy environments. Moreover, individual differences in SPN amplitude correlated with performance in a speech-in-noise test.</p><p><strong>Discussion: </strong>The increase in SPN amplitude was interpreted as reflecting the increased requirement for attentional resources for accurate prediction of speech information. These findings suggest that SPN could serve as a noninvasive neural marker for assessing individual differences in top-down processing involved in speech comprehension in noisy environments.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1479810"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiqiang Zhu, Dongsheng Tang, Lang Qin, Zhenyu Qian, Jie Zhuang, Yu Liu
{"title":"Syncing the brain's networks: dynamic functional connectivity shifts from temporal interference.","authors":"Zhiqiang Zhu, Dongsheng Tang, Lang Qin, Zhenyu Qian, Jie Zhuang, Yu Liu","doi":"10.3389/fnhum.2024.1453638","DOIUrl":"https://doi.org/10.3389/fnhum.2024.1453638","url":null,"abstract":"<p><strong>Background: </strong>Temporal interference (TI) stimulation, an innovative non-invasive brain stimulation approach, has the potential to activate neurons in deep brain regions. However, the dynamic mechanisms underlying its neuromodulatory effects are not fully understood. This study aims to investigate the effects of TI stimulation on dynamic functional connectivity (dFC) in the motor cortex.</p><p><strong>Methods: </strong>40 healthy adults underwent both TI and tDCS in a double-blind, randomized crossover design, with sessions separated by at least 48 h. The total stimulation intensity of TI is 4 mA, with each channel's intensity set at 2 mA and a 20 Hz frequency difference (2 kHz and 2.02 kHz). The tDCS stimulation intensity is 2 mA. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected before, during, and after stimulation. dFC was calculated using the left primary motor cortex (M1) as the region of interest (ROI) and analyzed using a sliding time-window method. A two-way repeated measures ANOVA (group × time) was conducted to evaluate the effects of TI and tDCS on changes in dFC.</p><p><strong>Results: </strong>For CV of dFC, significant main effects of stimulation type (<i>P</i> = 0.004) and time (<i>P</i> < 0.001) were observed. TI showed lower CV of dFC than tDCS in the left postcentral gyrus (<i>P</i> < 0.001). TI-T2 displayed lower CV of dFC than TI-T1 in the left precentral gyrus (<i>P</i> < 0.001). For mean dFC, a significant main effect of time was found (<i>P</i> < 0.001). TI-T2 showed higher mean dFC than tDCS-T2 in the left postcentral gyrus (<i>P</i> = 0.018). Within-group comparisons revealed significant differences between time points in both TI and tDCS groups, primarily in the left precentral and postcentral gyri (all <i>P</i> < 0.001). Results were consistent across different window sizes.</p><p><strong>Conclusion: </strong>20 Hz TI stimulation altered dFC in the primary motor cortex, leading to a significant decreasing variability and increasing mean connectivity strength in dFC. This outcome indicates that the 20 Hz TI frequency interacted with the motor cortex's natural resonance.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1453638"},"PeriodicalIF":2.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial: 15 years of Frontiers in Human Neuroscience: social cognition and discourse processing.","authors":"Patricia A Prelock, Vittorio Tantucci","doi":"10.3389/fnhum.2024.1506988","DOIUrl":"https://doi.org/10.3389/fnhum.2024.1506988","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1506988"},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Akbaş, Mariusz P Furmanek, Sarah Hsu, Mathew Yarossi, Eugene Tunik
{"title":"Perturbing reach elicits anticipatory responses in transport and grasp.","authors":"Anna Akbaş, Mariusz P Furmanek, Sarah Hsu, Mathew Yarossi, Eugene Tunik","doi":"10.3389/fnhum.2024.1423821","DOIUrl":"https://doi.org/10.3389/fnhum.2024.1423821","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to investigate whether the anticipation of a mechanical perturbation applied to the arm during a reach-to-grasp movement elicits anticipatory adjustments in the reach and grasp components. Additionally, we aimed to evaluate whether anticipatory adjustments in the upper limb might be global or specific to the direction of the perturbation.</p><p><strong>Methods: </strong>Thirteen healthy participants performed reach-to-grasp with perturbations randomly applied to their dominant limb. Participants were presented with three types of trials: unperturbed (control), trials perturbed in a predictable manner (either Up or Down), or perturbed in a partially predictable manner (knowledge about the perturbation but not its specific direction). EMG activity of 16 muscles, as well as the kinematics of wrist, thumb, and index finger, were acquired and analyzed.</p><p><strong>Results and discussion: </strong>When the perturbation was expected, EMG activity of the <i>triceps</i> and <i>pectoralis major</i> muscles significantly increased about 50 - 200 ms before the perturbation onset. Peak acceleration of the reach was significantly higher and occurred earlier relative to control trials. Similar adjustments were observed in the grasp kinematics, reflected as significantly shorter time to peak aperture velocity and acceleration, as well as in increased activity of <i>flexor</i> and <i>extensor digitorum</i> 100-200 ms before perturbation onset. In summary, our data demonstrate that knowledge of an upcoming perturbation of reach during reach-to-grasp action triggers anticipatory adjustments not only in the muscles controlling the reach component, but also in those controlling grasp. Furthermore, our data revealed that the preparatory activations were generalized, rather than direction specific.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1423821"},"PeriodicalIF":2.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-order brain network feature extraction and classification method of first-episode schizophrenia: an EEG study.","authors":"Yanxia Kang, Jianghao Zhao, Yanli Zhao, Zilong Zhao, Yuan Dong, Manjie Zhang, Guimei Yin, Shuping Tan","doi":"10.3389/fnhum.2024.1452197","DOIUrl":"10.3389/fnhum.2024.1452197","url":null,"abstract":"<p><strong>Introduction: </strong>A multimodal persistent topological feature extraction and classification method is proposed to enhance the recognition accuracy of first-episode schizophrenia patients. This approach addresses the limitations of traditional higher-order brain network analyses that rely on single persistent features (e.g., persistent images).</p><p><strong>Methods: </strong>The study utilized resting-state EEG data from 198 subjects recruited at Huilongguan Hospital in Beijing, comprising 102 males and 96 females, with a mean age of 30 years and mean education of 14 years. Persistent topological features were extracted using adaptive thresholding during persistent homology (PH) filtrations. The distribution of these features was visualized through heatmaps and persistence entropies, while the generation process was elucidated using Betti curves and persistence landscapes.</p><p><strong>Results: </strong>The classification performance of the multimodal persistent topological features was assessed using various machine learning classifiers. The classifier yielding the highest performance was selected for comparison with traditional brain network features derived from graph theory and single persistent topological features. The results revealed significant topological changes in first-episode schizophrenia patients throughout the persistent homology filtering compared to healthy subjects. The univariate feature selection algorithm achieved a classification accuracy of 94.6% with a combination of attributes meeting the criterion of AC ≥ 0.6.</p><p><strong>Discussion: </strong>The proposed method demonstrates clinical significance for the early identification and diagnosis of first-episode schizophrenia patients, offering a new research perspective for constructing higher-order functional connectivity networks and extracting topological structure features.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1452197"},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristina Molina-Hidalgo, Lu Wan, Daniel Velazquez-Diaz, Haiqing Huang, George Grove, Catherine M Bender, Amanda L Gentry, Susan M Sereika, Chaeryon Kang, Mary E Crisafio, Kirk I Erickson
{"title":"Effects of a 6-month aerobic exercise intervention on brain morphology in women with breast cancer receiving aromatase inhibitor therapy: a sub-study of the EPICC trial.","authors":"Cristina Molina-Hidalgo, Lu Wan, Daniel Velazquez-Diaz, Haiqing Huang, George Grove, Catherine M Bender, Amanda L Gentry, Susan M Sereika, Chaeryon Kang, Mary E Crisafio, Kirk I Erickson","doi":"10.3389/fnhum.2024.1443916","DOIUrl":"10.3389/fnhum.2024.1443916","url":null,"abstract":"<p><strong>Objective: </strong>Physical exercise may increase brain volume and cortical thickness in late adulthood. However, few studies have examined the possibility for exercise to influence brain morphology in women treated for breast cancer. We conducted a nested sub-study within a randomized clinical trial to examine whether 6 months of moderate-intensity aerobic exercise in postmenopausal women with early-stage breast cancer influences brain morphology.</p><p><strong>Methods: </strong>We included twenty-eight postmenopausal women newly diagnosed with Stage 0-IIIa breast cancer (M age = 62.96 ± 5.40) who were randomized to either 45-60 min of supervised aerobic exercise 3 days/week (<i>n</i> = 16) or usual care (<i>n</i> = 12). Before beginning aromatase inhibitor aromatase inhibitor therapy, and the exercise intervention, and again at 6-month follow-up, volumetric and cortical thickness measures were derived from magnetic resonance imaging scans.</p><p><strong>Results: </strong>There were no significant intervention effects on brain volume and cortical thickness. However, greater average exercise intensity (%) during the intervention was associated with greater post-intervention cortical volume, mean cortical thickness, precentral gyrus thickness, and superior parietal thickness (all <i>p</i> < 0.05). Finally, total supervised exercise time was associated with higher precentral gyrus thickness after the intervention (<i>p</i> = 0.042, <i>R</i> <sup>2</sup> = 0.263).</p><p><strong>Conclusion: </strong>The exercise intervention did not significantly affect brain volumes and cortical thickness compared to the control group. However, positive associations were found between exercise intensity and brain morphology changes after the 6-month intervention, indicating that exercise may reduce the vulnerability of the brain to the deleterious effects of breast cancer and its treatment.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1443916"},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovana Bjekić, Marko Živanović, Marija Stanković, Dunja Paunović, Uroš Konstantinović, Saša R Filipović
{"title":"The subjective experience of transcranial electrical stimulation: a within-subject comparison of tolerability and side effects between tDCS, tACS, and otDCS.","authors":"Jovana Bjekić, Marko Živanović, Marija Stanković, Dunja Paunović, Uroš Konstantinović, Saša R Filipović","doi":"10.3389/fnhum.2024.1468538","DOIUrl":"10.3389/fnhum.2024.1468538","url":null,"abstract":"<p><p>Low-intensity transcranial electrical stimulation (tES), including techniques like transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and oscillatory transcranial direct current stimulation (otDCS), has been widely explored for its neuromodulatory effects on motor, cognitive, and behavioral processes. Despite well-established safety, these techniques can induce varying degrees of discomfort and side effects, potentially impacting their application. This study presents a within-subject sham-controlled experiment directly comparing the subjective experience and side effects of tDCS, tACS, and otDCS. Participants reported their discomfort levels at multiple time points during 20-min stimulation sessions and completed a side-effects questionnaire before and after each session. Results indicated that the overall discomfort levels were low across all conditions, with ≥95% reporting the absence of discomfort or mild procedure-induced discomfort. Nevertheless, tDCS and otDCS were slightly less comfortable compared to sham, especially at the beginning of stimulation, with tACS-induced discomfort levels being overall comparable to sham. The most common side / adverse effects were mild skin sensations, including itching and tingling, particularly with tDCS and otDCS, while tACS occasionally caused phosphenes and blurred vision. These findings provide a systematic comparison of tES-induced discomfort and side effects between different tES techniques, highlighting the high safety of tES, but also the importance of considering within- and between-person variability and time-course effects in tES applications.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1468538"},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurophysiological approaches to exploring emotional responses to cosmetics: a systematic review of the literature.","authors":"Audrey Diwoux, Damien Gabriel, Marie-Héloïse Bardel, Youcef Ben Khalifa, Pierre-Édouard Billot","doi":"10.3389/fnhum.2024.1443001","DOIUrl":"10.3389/fnhum.2024.1443001","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review explores the use of neurophysiological measurements to study emotional responses to cosmetic products. The aim is to evaluate existing literature on these measurements in cosmetics, identify the main findings, highlight methodological challenges, and propose new guidelines for future research.</p><p><strong>Method: </strong>A systematic search focusing on neurophysiological measures to determine emotions induced by different cosmetic products was carried out in accordance with PRISMA guidelines.</p><p><strong>Results: </strong>A total of 33 articles identified with the EBSCO database met the inclusion criteria. In all, 10 different measurement tools were used in these articles to assess the emotional effects of cosmetic products.</p><p><strong>Discussion: </strong>This review emphasizes the complexity of interactions between cosmetics and emotional responses. It underscores the importance of future research with a more holistic approach that couples several physiological measurements. Among them, electrophysiological brain activity shows potential for enhancing understanding of emotional responses related to cosmetic products. Frontal asymmetry, particularly in the alpha frequency band, was often use and frequently linked to positive emotional states, although conflicting evidence exists. Additionally, cardiac activity, specifically the LF/HF ratio, emerges as a promising marker for differentiating between different cosmetic products. However, methodological heterogeneity, present challenges for replicability, generalizability, and complicate data interpretation.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1443001"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minkyu Ahn, Bradley Jay Edelman, Bin He, Gernot R Müller-Putz, Florian Röhrbein
{"title":"Editorial: Advances in hybrid and application-driven BCI systems.","authors":"Minkyu Ahn, Bradley Jay Edelman, Bin He, Gernot R Müller-Putz, Florian Röhrbein","doi":"10.3389/fnhum.2024.1498196","DOIUrl":"https://doi.org/10.3389/fnhum.2024.1498196","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1498196"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giorgio Lazzari, Lucia Maria Sacheli, Charles-Etienne Benoit, Carlotta Lega, Floris T van Vugt
{"title":"Pleasantness makes a good time: musical consonance shapes interpersonal synchronization in dyadic joint action.","authors":"Giorgio Lazzari, Lucia Maria Sacheli, Charles-Etienne Benoit, Carlotta Lega, Floris T van Vugt","doi":"10.3389/fnhum.2024.1472632","DOIUrl":"10.3389/fnhum.2024.1472632","url":null,"abstract":"<p><strong>Introduction: </strong>Music making is a process by which humans across cultures come together to create patterns of sounds that are aesthetically pleasing. What remains unclear is how this aesthetic outcome affects the sensorimotor interaction between participants.</p><p><strong>Method: </strong>Here we approach this question using an interpersonal sensorimotor synchronization paradigm to test whether the quality of a jointly created chord (consonant vs. dissonant) affects movement coordination. We recruited non-musician participants in dyads to perform a dyadic synchronization-continuation task (dSCT): on each trial, participants first synchronized their movements to a metronome (synchronization phase) and then continued tapping together at the same tempo without the metronome (continuation phase). Each tap yielded a note and participants heard both their own and that of their partner, thus creating a chord that was varied to be either consonant (Perf5 or Maj6) or dissonant (Min2 or Maj2). For each trial, participants also rated the pleasure they felt in creating the sounds together. Additionally, they completed questionnaires about social closeness to the other participant, musical reward sensitivity and musical training.</p><p><strong>Results: </strong>Results showed that participants' taps were closer in time when they jointly created consonant (high pleasure) vs. dissonant (low pleasure) chords, and that pleasure experienced by the dyad in each trial predicted interpersonal synchronization. However, consonance did not affect individual synchronization with the metronome or individual tapping when the metronome was discontinued. The effect of consonance on synchronization was greater in dyads who reported feeling less close prior to the task.</p><p><strong>Discussion: </strong>Together, these results highlight the role of consonance in shaping the temporal coordination of our actions with others. More broadly, this work shows that the aesthetic outcome of what we create together affects joint behaviors.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1472632"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}