Frontiers in Human Neuroscience最新文献

{"title":"Systematic review and meta-analysis of effectiveness of robotic therapy in the recovery of motor functions after stroke.","authors":"Mariyam Amirbekova, Tokzhan Kispayeva, Ausra Adomaviciene, Laura Eszhanova, Inna Bolshakova, Zhanna Ospanova","doi":"10.3389/fnhum.2025.1622661","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1622661","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a leading cause of adult disability worldwide, often resulting in persistent motor impairments. While conventional rehabilitation approaches often yield modest results, robotic-assisted therapy has emerged as a promising solution to enhance motor recovery. However, the impact of stroke phase (acute, subacute, chronic) and other clinical modifiers on the effectiveness of robotic rehabilitation remains underexplored.</p><p><strong>Methods: </strong>The protocol for this systematic review and meta-analysis was registered in PROSPERO under the registration number CRD420251038754. A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. The literature search was conducted using MEDLINE, PubMed, Cochrane Library, Scopus, Web of Science, and EMBASE. Risk of bias was assessed using the RoB 2.0. Primary outcomes included motor recovery, gait speed, and balance. A random-effects model (DerSimonian-Laird) was applied to calculate pooled standardized mean differences (SMD), and subgroup analyses and meta-regression were used to assess the influence of stroke phase, age, therapy duration, and combined interventions (e.g., virtual reality, mirror therapy).</p><p><strong>Results: </strong>Thirteen randomized controlled trials (RCTs) published between 2015 and 2025 were included, with a total of 424 post-stroke patients. Robotic therapy showed a moderate but statistically significant effect over conventional rehabilitation (SMD = 0.59, 95% CI: [0.33; 0.84], <i>p</i> < 0.001), with low-to-moderate heterogeneity (I² = 30.5%). Subgroup analysis revealed the strongest effects during the subacute phase (SMD = 0.74) and acute phase (SMD = 0.75), while the chronic phase yielded limited improvement (SMD = 0.23). Younger age and a intervention duration of more than 6 weeks were associated with enhanced outcomes. Meta-regression indicated a trend toward reduced effectiveness with prolonged intervention duration (<i>β</i> = -0.134), although not statistically significant (<i>p</i> = 0.102). No publication bias was detected (Egger's <i>p</i> = 0.56).</p><p><strong>Conclusion: </strong>Robotic-assisted therapy provides clinically meaningful improvements in post-stroke motor recovery. The findings support early stratification and personalization of rehabilitation programs based on stroke timing, age, and intervention intensity. Integration of robotic systems with virtual and cognitive components may further enhance neuroplasticity, leading to improved functional outcomes.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD420251038754.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1622661"},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Neuro-behavioral insights on low vision and beyond.","authors":"Susana Chung, Diego Ghezzi, Ahalya Subramanian, Silvio Ionta","doi":"10.3389/fnhum.2025.1652389","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1652389","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1652389"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive dysfunctions in patients with low-grade gliomas in the supplementary motor area: a neuropsychological perspective.","authors":"Aleksandra Bala, Agnieszka Olejnik, Weronika Rejner, Antonina Gottman-Narożna, Kacper Koczyk, Tomasz Dziedzic, Przemysław Kunert","doi":"10.3389/fnhum.2025.1554063","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1554063","url":null,"abstract":"<p><strong>Introduction: </strong>The supplementary motor area (SMA) is one of the more common locations where low-grade gliomas (LGG) are found. It is an area that, in addition to controlling movement, is also involved in a range of cognitive functions, including executive functions, but data on this topic is still scarce. The aim of this study was a comprehensive assessment of executive functions, as well as an evaluation of clinical variables that may influence the obtained results.</p><p><strong>Materials and methods: </strong>The study included 23 patients with LGG tumors located in the SMA and a control group of 57 healthy individuals. They were all tested using a set of neuropsychological tests: the Stroop Test, the Verbal Fluency Test, the Tower of London Test, and the Wisconsin Card Sorting Test.</p><p><strong>Results: </strong>The conducted analyses revealed the presence of significant differences between groups in terms of selected indicators of each test. Furthermore, the results of individual TOL and WCST indicators showed significant correlations with the tumor volume. The comparison of patients with tumors in the left and right hemispheres revealed differences solely in WCST performance, with those having left SMA damage performing worse. There were also differences in the performance of the WCST test to the disadvantage of patients who had epileptic seizures compared to those who did not. Moreover, patients with oligodendrogliomas scored lower than those with astrocytomas on some of the WCST indices.</p><p><strong>Conclusions: </strong>Patients with LGG tumors in the supplementary motor area present a wide range of executive dysfunctions, including planning, reasoning, inhibition, switching, and cognitive flexibility. Both the volume and type of tumor, the hemisphere in which it is located and the occurrence of epileptic seizures may be related to the results. Future studies with larger cohorts are needed to confirm these findings.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1554063"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of microstructural abnormalities in gray and white matter of minimal hepatic encephalopathy patients using diffusion kurtosis imaging and their associations with neurocognitive dysfunction.","authors":"Qing Sun, Wenliang Fan, Yuan Liu, Zhifeng Kou, Ping Han","doi":"10.3389/fnhum.2025.1600100","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1600100","url":null,"abstract":"<p><strong>Aims: </strong>Although neural activity abnormalities have been reported in cirrhosis patients with minimal hepatic encephalopathy (MHE), the neurophysiological mechanisms underlying microstructural brain alterations remain poorly understood. This prospective study aimed to assess microstructural abnormalities in both gray matter and white matter of MHE patients by using diffusion kurtosis imaging (DKI), and to examine associations between these alterations and neurocognitive and clinical measurements.</p><p><strong>Methods: </strong>Thirty-one Hepatitis B Virus-related cirrhotic patients without MHE (NMHE), thirty Hepatitis B Virus-related cirrhotic patients with MHE, and 59 gender-, age-, education-matched healthy controls underwent diffusional kurtosis imaging and neurocognitive assessments. We used tract-based spatial statistics (TBSS) analysis to estimate group differences of white matter (WM) microstructure and voxel-based morphometry analysis to determine gray matter (GM) abnormalities. Correlation analyses were further performed to assess relationships between altered diffusional parameters and clinical variables, such as neurocognitive performances and disease duration.</p><p><strong>Results: </strong>The TBSS analysis results showed that MHE patients had significantly decreased fractional anisotropy (FA) in the temporal part of the left superior longitudinal fasciculus and decreased kurtosis fractional anisotropy (KFA) in the left corticospinal tract and anterior thalamic radiation (<i>p</i> < 0.05, threshold-free cluster enhancement corrected). Notably, lower KFA in WM regions correlated with worse neurocognitive test scores in MHE patients. For GM, MHE patients exhibited increased volume of thalamus. No significant WM or GM differences were observed between NMHE patients and the other two groups.</p><p><strong>Conclusion: </strong>Minimal hepatic encephalopathy patients demonstrated microstructural abnormalities in both WM and GM, predominantly affecting regions involved in cognitive, attention, and motor functions. These findings suggest that disruption of microstructural integrity may underlie the pathophysiological underpinnings of neurocognitive dysfunction in MHE, offering neuroimaging evidence for disease mechanisms.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1600100"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical perspectives on neuropsychological rehabilitation: challenges, expectations, and family involvement.","authors":"Carlos Ramos-Galarza, Jhonny Gaibor","doi":"10.3389/fnhum.2025.1581304","DOIUrl":"10.3389/fnhum.2025.1581304","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1581304"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of higher cognitive functions following posterior quadrant disconnection in the non-dominant hemisphere: a Case Report.","authors":"Noeru Kawase, Shunsuke Nakae, Masanobu Kumon, Motoharu Hayakawa, Chiaki Shinzato, Yuriko Sato, Takehiro Uda, Takumi Mitsuhashi, Masaki Fukunaga, Shigeo Ohba, Yuichi Hirose","doi":"10.3389/fnhum.2025.1569673","DOIUrl":"10.3389/fnhum.2025.1569673","url":null,"abstract":"<p><p>Posterior Quadrant Disconnection is a surgical technique designed to suppress seizure propagation while preserving motor and sensory functions in patients with drug-resistant epilepsy. Although seizure outcomes following this procedure have been reported, detailed evaluations of its impact on higher cognitive functions remain limited. This study aimed to assess the long-term seizure and cognitive outcomes following PQD in the non-dominant hemisphere, thereby evaluating the efficacy and safety of the procedure. In this case, the patient with drug-resistant epilepsy underwent preoperative evaluation using stereo electroencephalography (SEEG) to identify seizure onset zones and functional mapping related to visuospatial cognition. Following this assessment, PQD was performed. Postoperative outcomes were monitored over a 2-years period, focusing on seizure control and higher cognitive function. The patient achieved Engel class I status postoperatively, indicating complete seizure cessation. While transient hemispatial neglect was observed immediately after surgery, gradual improvement was noted over time. Furthermore, visual memory and cognitive functions showed a tendency to improve, and there were no significant declines in facial recognition or scene recognition abilities. These findings suggest that PQD can effectively improve seizure outcomes while minimizing long-term impacts on cognitive functions. This case highlights the potential of PQD to offer substantial seizure control with limited permanent effects on higher cognitive functions. By providing valuable insights into the safety and efficacy of PQD in the non-dominant hemisphere, this study underscores its viability as a treatment option for selected cases of drug-resistant epilepsy.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1569673"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced nicotine dependence following traumatic brain injury in an elderly patient: a case report and literature review.","authors":"Min Yuan, Renshi Xu","doi":"10.3389/fnhum.2025.1619775","DOIUrl":"10.3389/fnhum.2025.1619775","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) can induce a range of neurological and behavioral changes, including potential effects on substance dependence. We present the case of an 87-year-old male with a longstanding history of heavy smoking (~60 pack-years) who demonstrated an abrupt cessation of nicotine craving following a severe TBI involving subdural hemorrhage, contusions, and subarachnoid hemorrhage. Clinical management included supportive therapy for intracranial pressure control and infection management. Nicotine dependence and craving were qualitatively assessed through repeated structured clinical interviews during hospitalization and outpatient follow-up. Remarkably, during the six-month follow-up, the patient remained abstinent without signs of withdrawal or nicotine craving and the use of pharmacological or behavioral interventions. This case highlights a rare but significant phenomenon suggesting that severe brain injury may disrupt mesolimbic dopaminergic circuits, including the ventral tegmental area (VTA) and nucleus accumbens (NAc), central to nicotine-related reward processing. We discuss potential neurobiological mechanisms post-injury, including dopaminergic dysfunction and health behavior adaptation. Further research is needed to elucidate the underlying pathways and clinical implications of TBI-associated changes in addictive behaviors.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1619775"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The impact of internet pornography addiction on brain function: a functional near-infrared spectroscopy study.","authors":"Qicheng Shu, Shiyu Tang, Zhenhua Wu, Jiahuan Feng, Wenhao Lv, Min Huang, Fan Xu","doi":"10.3389/fnhum.2025.1658882","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1658882","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnhum.2025.1477914.].</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1658882"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: From bench to bedside: inflammation in neurovascular disorders and stroke.","authors":"Mohd Farooq Shaikh, Rony Abdi Syahputra, Mohd Kaisan Mahadi","doi":"10.3389/fnhum.2025.1658045","DOIUrl":"10.3389/fnhum.2025.1658045","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1658045"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of immunoglobulin G4-related spinal pachymeningitis.","authors":"Bingxue Zhang, Lenan Kang, Xiaohong Li","doi":"10.3389/fnhum.2025.1541096","DOIUrl":"10.3389/fnhum.2025.1541096","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1541096"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}