Frontiers in Human Neuroscience最新文献

{"title":"Editorial: Advances in brain imaging and stimulation methods for cognitive function investigation, volume II.","authors":"Mengze Xu, Yuwen He, Yujing Huang, Zhen Yuan","doi":"10.3389/fnhum.2025.1611543","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1611543","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1611543"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video-evoked neuromarkers of visual function in age-related macular degeneration.","authors":"Angela I Renton, David J Klein, Jesse A Livezey, Dan Nemrodov, Stephanie Wolfer, Adam Hanina, Dimitri Van De Ville","doi":"10.3389/fnhum.2025.1569282","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1569282","url":null,"abstract":"<p><p>Neural markers of visual function in age-related macular degeneration (AMD) allow clinicians and researchers to directly evaluate the functional changes in visual processing which occur as a result of the progressive loss of afferent input from the macula. Unfortunately, few protocols exist that elicit such neural markers, and most of these are poorly adapted to AMD. Here, we propose a novel method of embedding frequency tags into full color and motion videos by periodically manipulating the contrast of visual information of different spatial frequencies at different temporal frequencies. These videos elicit steady-state visual evoked potentials (SSVEPS) in viewers which, when measured using electrophysiological neuroimaging methods, independently represent the responses of populations of neurons tuned to the tagged spatial frequencies. We used electroencephalography (EEG) to record the SSVEPs of 15 AMD patients and 16 age-matched healthy controls watching a 6-min series of natural scene videos filtered with this spatial frequency tagging method. Compared with healthy controls, AMD patients showed a lower SSVEP to high spatial frequency information, and a stronger response to the low spatial frequency information in the video set. The ratio of the SSVEP to lower relative to higher spatial frequency information was strongly predictive of both visual acuity and contrast sensitivity, and the topographic distributions of these responses suggested retinotopic reorganization of the neural response to spatial frequency information.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1569282"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Deep brain stimulation think tank: updates in neurotechnology and neuromodulation, volume V.","authors":"Alfonso Enrique Martinez-Nunez, Sarah-Anna Hescham, Adolfo Ramirez-Zamora, Michael S Okun, Joshua K Wong","doi":"10.3389/fnhum.2025.1609727","DOIUrl":"10.3389/fnhum.2025.1609727","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1609727"},"PeriodicalIF":2.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The neuroscience of Parkinson's disease: exploring causes, symptoms, and potential treatments.","authors":"Jurgen Germann, Sandra Neumann","doi":"10.3389/fnhum.2025.1609635","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1609635","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1609635"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review.","authors":"Betina Franceschini Tocchetto, Andrea Cristiane Janz Moreira, Álvaro de Oliveira Franco, Iraci L S Torres, Felipe Fregni, Wolnei Caumo","doi":"10.3389/fnhum.2025.1548617","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1548617","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) often co-occur with fibromyalgia (FM), and both conditions have been associated with impaired resting state functional connectivity (rs-FC). The present systematic review aims to summarize the evidence on rs-FC in individuals with MDD and FM compared with healthy controls and explore overlapping connectivity patterns and their relationships with clinical symptoms.</p><p><strong>Methods: </strong>A systematic search of the EMBASE, PubMed, Scopus and ScienceDirect databases was conducted according to PRISMA guidelines. Studies were included that addressed rs-FC using seed-based analysis in MDD and FM patients compared to HC. Methodological quality and risk of bias were assessed using a 13-point checklist adapted from previous neuroimaging meta-analyzes.</p><p><strong>Results: </strong>A total of 33 articles were included in the analysis (17 with MDD and 16 with FM). The sample comprised 1,877 individuals, including 947 patients and 930 controls, with a mean age of 39.83 years. The seeds were categorized into six neural networks. Shared disruptions across MDD and FM studies have been identified in key circuits, including decreased connectivity between the insula and anterior cingulate cortex (ACC), middle frontal gyrus (MFG), superior frontal gyrus (SFG), and putamen. Increased FC was observed between the dorsolateral prefrontal cortex (DLPFC) and ACC, as well as between the thalamus and precuneus. Decreased insula-ACC connectivity correlated with greater pain intensity and catastrophizing in FM and with more severe depressive symptoms in MDD. Unique patterns of rs-FC were also observed: FM-specific changes involved the periaqueductal gray, hypothalamus, and thalamus, indicating impaired pain modulation and emotional processing. In contrast, MDD-specific changes were primarily observed in the reward, salience, and default mode networks, reflecting impaired emotional regulation. The studies showed considerable heterogeneity in the selection of seeds and study designs, which limits the feasibility of meta-analyses and underlines the need for standardized methods.</p><p><strong>Findings: </strong>This study provides information about overlapping and distinct neural mechanisms in FM and MDD, suggesting potentially the presence of a potential neurosignature that reflects shared disruptions in pain and emotion regulation networks while highlighting unique pathways underlying their respective pathophysiology.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1548617"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An acoustic model of speech dysprosody in patients with Parkinson's disease.","authors":"Fredrik Nylén","doi":"10.3389/fnhum.2025.1566274","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1566274","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the acoustic properties most indicative of dysprosody severity in patients with Parkinson's disease using an automated acoustic assessment procedure.</p><p><strong>Method: </strong>A total of 108 read speech recordings of 68 speakers with PD (45 male, 23 female, aged 65.0 ± 9.8 yea<i>rs</i>) were made with active levodopa treatment. A total of 40 of the patients were additionally recorded without levodopa treatment to increase the range of dysprosody severity in the sample. Four human clinical experts independently assessed the patients' recordings in terms of dysprosody severity. Separately, a speech processing pipeline extracted the acoustic properties of prosodic relevance from automatically identified portions of speech used as utterance proxies. Five machine learning models were trained on 75% of speech portions and the perceptual evaluations of the speaker's dysprosody severity in a 10-fold cross-validation procedure. They were evaluated regarding their ability to predict the perceptual assessments of recordings excluded during training. The models' performances were assessed by their ability to accurately predict clinical experts' dysprosody severity assessments.</p><p><strong>Results: </strong>The acoustic predictors of importance spanned several acoustic domains of prosodic relevance, with the variability in <i>f</i> _<i>o</i> change between intonational turning points and the average first Mel-frequency cepstral coefficient at these points being the two top predictors. While predominant in the literature, variability in utterance-wide <i>f</i> _<i>o</i> was <i>fo</i>und to be only the fifth strongest predictor.</p><p><strong>Conclusion: </strong>Human expert raters' assessments of dysprosody can be approximated by the automated procedure, affording application in clinical settings where an experienced expert is unavailable. Variability in pitch does not adequately describe the level of dysprosody due to Parkinson's disease.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1566274"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG dynamical features during variable-intensity cycling exercise in Parkinson's disease.","authors":"Zahra Alizadeh, Emad Arasteh, Maryam S Mirian, Matthew A Sacheli, Danielle Murray, Silke Appel-Cresswell, Martin J McKeown","doi":"10.3389/fnhum.2025.1571106","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1571106","url":null,"abstract":"<p><strong>Background: </strong>Exercise is increasingly recognized as a beneficial intervention for Parkinson's disease (PD), yet the optimal type and intensity of exercise remain unclear. This study investigated the relationship between exercise intensity and neural responses in PD patients, using electroencephalography (EEG) to explore potential neural markers that could be ultimately used to guide exercise intensity.</p><p><strong>Method: </strong>EEG data were collected from 14 PD patients (5 females) and 8 healthy controls (HC) performing stationary pedaling exercises at 60 RPM with resistance adjusted to target heart rates of 30, 40, 50, 60, and 70% of maximum heart rate. Subjects pedaled for 3 min at each intensity level in a counterbalanced order. Canonical Time-series Characteristics (Catch-22) features and Multi-set Canonical Correlation Analysis (MCCA) were utilized to identify common profiles of EEG features at increasing exercise intensity across subjects.</p><p><strong>Results: </strong>We identified a statistically significant MCCA component demonstrating a monotonic relationship with pedaling intensity. We have discovered nine features which show significant trends across intensity (<i>p</i>-value<0.01), and the dominant feature in this component was Periodicity Wang (<i>p</i>-value<0.0001), related to the autocorrelation of the EEG. Analysis revealed a consistent trend across features: six features increased with intensity, indicating heightened rhythmic engagement and sustained neural activation, while three features decreased, suggesting reduced variability and enhanced predictability in neural responses. Notably, PD patients exhibited more rigid, consistent response patterns compared to healthy controls (HC), who showed greater flexibility and variability in their neural adaptation across intensities.</p><p><strong>Conclusion: </strong>This study highlights the feasibility of using EEG-derived features to track exercise intensity in PD patients, identifying specific neural markers correlating with varying intensity levels. PD subjects demonstrate less inter-subject variability in motor responses to increasing intensity. Our results suggest that EEG biomarkers can be used to assess differing brain involvement with the same exercise of increasing intensity, potentially useful for guiding targeted therapeutic strategies and maximizing the neurological benefits of exercise in PD.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1571106"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in magnetic field approaches for non-invasive targeting neuromodulation.","authors":"Mozhgan Alipour, Maryam Abdolmaleki, Yaser Shabanpour, Alireza Zali, Farzad Ashrafi, Shabnam Nohesara, Behnam Hajipour-Verdom","doi":"10.3389/fnhum.2025.1489940","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1489940","url":null,"abstract":"<p><p>Neuromodulation, the targeted regulation of nerve activity, has emerged as a promising approach for treating various neurological and psychiatric disorders. While deep brain stimulation has shown efficacy, its invasive nature poses substantial risks, including surgical complications and high costs. In contrast, non-invasive neuromodulation techniques, particularly those utilizing magnetic fields (MFs), have gained increasing attention as safer, more accessible alternatives. Magnetothermal stimulation has emerged as an innovative method that enables precise modulation of neuronal ion channels through localized heating induced by interaction of MF with biological tissues. This review discusses the principles of MF-based neuromodulation and highlights the critical role of ion channels in synaptic transmission, and the therapeutic potential of these advanced techniques. Additionally, it highlights key challenges such as spatial targeting precision, safety considerations, and the long-term effects of magnetic exposure on brain function. The findings presente the promise of MF-based neuromodulation as a non-invasive, highly targeted therapeutic strategy for conditions such as epilepsy, movement disorders, and neurodegenerative diseases, with potential applications in chronic pain management and future clinical interventions.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1489940"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation in individuals with severe traumatic brain injury in the subacute phase: a case series.","authors":"Barbara Naeme de Lima Cordeiro, Jader Vinicius Da Silva Rocha, Elizangela Kuster, Aurore Thibauth, Lucas Rodrigues Nascimento, Chad Swank, Guilherme Peixoto Tinoco Arêas, Walter Gomes da Silva Filho, Carolina Fiorin Anhoque, Wellingson Silva Paiva, Jéssica Costa Buarque, Fernando Zanela Arêas","doi":"10.3389/fnhum.2025.1552387","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1552387","url":null,"abstract":"<p><p>The aim of this study is to report clinical cases of patients with severe traumatic brain injury (TBI) who underwent transcranial direct current stimulation (tDCS) in the subacute phase. We hypothesize that tDCS will improve the functional and cognitive recovery of patients. 5 men, admitted with severe TBI, and Glasgow Coma Scale (GCS) score ≤ 8 on admission or at some point during hospitalization, were in the subacute phase of the trauma (between 2 and 16 weeks). Participants received 5 sessions of tDCS every day. The results were measured at the beginning and at the end of the 5 sessions. The application of tDCS with an active electrode (anode) was applied to the region of the left dorsolateral prefrontal cortex (LPFC - F3) and the cathode was positioned over the contralateral supraorbital area. Clinical outcomes were measured through cognitive assessment, Mini Mental State Examination (MMSE), mental health and depression, Hospital Anxiety and Depression Scale (HADS-A), pain, visual analogue scale (VAS), Functional Independence Measure (FIM), Rancho Los Amigos Scale (RLAS) and Glasgow Outcome Scale - Extended (GOS-E), were applied to classify the patient's condition. For characteristics of participants and findings results, descriptive statistics were presented as mean ± Standard Deviation (SD). The results after the tDCS intervention show substantial improvement in the assessed. The research demonstrates the potential benefits of using tDCS in patients with TBI, but also provides a practical basis for applying these techniques in clinical settings.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1552387"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: EEG-based multivariate and univariate analyses reveal the mechanisms underlying the recognition-based production effect: evidence from mixed-list design.","authors":"Bohua Zhang, Alhassan Abdullah, Minmin Yan, Yongqing Hou, Antao Chen, Helen McLaren","doi":"10.3389/fnhum.2025.1601104","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1601104","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnhum.2025.1507782.].</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1601104"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}