Frontiers in Human Neuroscience最新文献

{"title":"Human induced pluripotent stem cell models for Alzheimer's disease research: a bibliometric analysis.","authors":"Yuning Sun, Zhilong Liu, Zongbo Zhang, Yufeng Kang, Xinlian Wang, Yiping Zhang, Yan Liu, Pei Zhao","doi":"10.3389/fnhum.2025.1548701","DOIUrl":"10.3389/fnhum.2025.1548701","url":null,"abstract":"<p><strong>Introduction: </strong>Alzheimer's disease (AD), the leading cause of dementia, remains without adequate treatment. Current models do not fully replicate human physiology and pathology. The advent of human induced pluripotent stem cell (hiPSC) technology offers a novel approach to studying AD.</p><p><strong>Methods: </strong>Our study conducted a bibliometric analysis to assess the application and development of hiPSC technology in AD research. We retrieved 531 articles on hiPSC models of AD from the Web of Science Core Collection, published between January 2010 and June 2024. CiteSpace and VOSviewer were used to analyze authorship, geographic contributions, journal influence, and citation patterns.</p><p><strong>Results: </strong>Our findings reveal a steady increase in publications over 14 years, with the United States leading in contributions, followed by China. Li-Huei Tsai from the Massachusetts Institute of Technology is a prominent researcher. <i>PLoS One</i> emerges as the most influential journal. Research trends have focused on inflammation, astrocytes, microglia, apolipoprotein E (ApoE), and tau.</p><p><strong>Discussion: </strong>Bibliometric analysis is crucial in identifying research gaps and trends and guiding future studies to address unmet needs in understanding and modeling human physiology and pathology. Leveraging hiPSC models to investigate the molecular mechanisms of familial and sporadic AD is expected to provide a crucial foundation for developing future treatment strategies.</p><p><strong>Conclusion: </strong>In summary, the bibliometric findings from this study provide a comprehensive overview of the current research landscape in hiPSC models for AD. It also highlights emerging trends and research gaps, crucial for guiding future research efforts, particularly in exploring novel therapeutic targets and improving understanding of disease mechanisms.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1548701"},"PeriodicalIF":2.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ConNECT approach: toward a comprehensive understanding of meaningful interpersonal moments in psychotherapy and beyond.","authors":"Niclas Kaiser, Juan Camilo Avendano-Diaz","doi":"10.3389/fnhum.2025.1549203","DOIUrl":"10.3389/fnhum.2025.1549203","url":null,"abstract":"<p><p>Relational neuroscience struggles to capture the complex dynamics of shared interpersonal moments, leading to gaps in understanding whether and how interdependencies between interacting persons translate into something meaningful. Current neuroscientific research often focuses on motor synchronization and cognition rather than the implicit relational qualities central to psychotherapy. We argue that this disconnect stems from an over-reliance on simplified quantitative methods, a failure to centralize experiential factors, and the lack of Convergence research. Drawing on emerging frameworks such as 4E cognition (embodied, enacted, extended, and embedded) and MoBI (Mobile Brain/Body Imaging), we advocate for integrating subjective and experiential elements with neural data. We propose focusing on \"qualities\" in multi-brain neuroscience-moving beyond binary or linear scales-to better capture the subtleties of relational moments. Finally, we emphasize the importance of convergence research across disciplines to better understand what interpresence holds. If psychotherapeutic knowledge is used to guide neuroscientists in what to look for, this multi-disciplinary approach holds promise for advancing the study of psychotherapy's relational processes, offering new insights into the neurobiology of meaningful moments in therapy and elsewhere. We propose ConNECT (Convergence research including Neuroscience and Experiences, Capturing meaningful dynamics with Therapists' knowledge) as the path forward.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1549203"},"PeriodicalIF":2.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effects of construction industry noise on workers' cognitive performance and learning efficiency.","authors":"Xinying Cao, Yian Lu, Decheng Zheng, Peicheng Qin","doi":"10.3389/fnhum.2025.1549824","DOIUrl":"10.3389/fnhum.2025.1549824","url":null,"abstract":"<p><p>Despite growing industrialization, the cognitive and psychological impacts of construction noise on workers remain inadequately addressed in empirical research. This study examines the impact of different noise types and intensities on the cognitive performance and learning efficiency of construction workers, using electroencephalogram (EEG) and behavioral data. Specifically, it analyzes the effects of complex noise and steady noise on workers' attention, mental workload, mental fatigue, and mental stress. The results indicate that complex noise significantly reduces learning efficiency, notably impairing accuracy and reaction time relative to steady noise. This adverse effect is attributed to the unpredictability and variability of complex noise, which disrupts workers' cognitive processing and heightens mental fatigue. In contrast, although steady noise does not significantly impact mental workload, it induces greater mental fatigue and mental stress than complex noise, especially at high noise levels. The findings also reveal that workers develop some level of adaptation to continuous noise, mitigating its overall impact on learning efficiency. However, elevated noise levels, regardless of type, consistently lead to significant declines in attention and increases in mental stress and mental fatigue. This research makes an original contribution by providing evidence-based insights into the interaction between noise characteristics and worker cognition, offering practical implications for targeted noise management strategies to improve learning efficiency and well-being in construction environments.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1549824"},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive factors on the performance of group decision-making: a behavioral and eye-tracking study.","authors":"Cheng Kexin, Jiang Zuhua, Yang Jiapeng","doi":"10.3389/fnhum.2025.1551447","DOIUrl":"10.3389/fnhum.2025.1551447","url":null,"abstract":"<p><strong>Introduction: </strong>To foster innovation and optimization in engineering product design, it is crucial for engineering professionals to effectively integrate knowledge and make informed decisions within interdisciplinary collaborative environments. Understanding the factors that influence group decision-making performance can enhance communication and knowledge integration among experts from diverse disciplinary backgrounds. By analyzing decision-makers' attention allocation and information processing at the cognitive level, the innovation and practicality of solutions can be significantly improved. However, the complexity and multitude of factors affecting decision-making performance pose challenges, particularly due to the lack of quantitative research and unified metrics at both group and cognitive levels. This gap hinders the quality and efficiency of engineering group decisions.</p><p><strong>Methods: </strong>This study introduces an eye-tracking method to investigate interdisciplinary group decision-making in engineering design, leveraging group decision-making performance theory and eye-tracking technology. Experiments were conducted in the context of Chinese cruise ship cabin design. Using Partial Least Squares Structural Equation Modeling (PLS-SEM), a quantitative model was developed to assess the impact of visual attention on group decision performance.</p><p><strong>Results: </strong>The results demonstrate that group average gaze duration and group average number of gazes directly influence group decision-maker satisfaction and decision acceptability. Furthermore, these factors indirectly affect interdisciplinary group decision-making performance by impacting group decision quality.</p><p><strong>Discussion: </strong>The findings provide a foundation for developing effective interdisciplinary group decision support systems, enhancing cognitive performance, and offering new methodological insights for future engineering design decisions. This research contributes to bridging the gap in quantitative assessment of group decision-making performance, paving the way for improved decision quality and efficiency in engineering contexts.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1551447"},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of body image on the kinematics of gait initiation.","authors":"Kyosuke Oku, Shinsuke Tanaka, Yukiko Nishizaki, Chie Fukada, Noriyuki Kida","doi":"10.3389/fnhum.2025.1560138","DOIUrl":"10.3389/fnhum.2025.1560138","url":null,"abstract":"<p><p>In daily life, we walk naturally by considering our physical characteristics and formulating appropriate motor plans. However, the impact of changes in body image on walking movements during motor planning remains poorly understood. Therefore, in this study, we examined changes in walking behavior under different conditions where body image was altered. We included 26 participants (13 men and 13 women, aged 18.27 ± 0.52) who performed walking movements under five conditions: eyes open, eyes covered, eyes covered while imagining their bodies becoming larger, eyes covered without imagining altered body size, and eyes open again. As a result, under the condition where participants imagined their bodies becoming larger, their step length, step completion time, and foot lift height increased. To generate a torque larger than the actual body size, the participants made a motor planning with a larger body image, resulting in an increase in step length. Since these results are attributed to the disparity between actual body size and body image, which affects motor planning, our findings have potential applications in rehabilitation and sports coaching settings.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1560138"},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precuneus activation correlates with the vividness of dynamic and static imagery: an fMRI study.","authors":"Suna Duan, Qingfeng Li, Junjie Yang, Qing Yang, Enran Li, Yuting Liu, Lijuan Jiang, Chunbo Li, Binglei Zhao","doi":"10.3389/fnhum.2025.1516058","DOIUrl":"10.3389/fnhum.2025.1516058","url":null,"abstract":"<p><strong>Introduction: </strong>Visual mental imagery (VMI) is a cognitive function that significantly impacts various aspects of daily life. However, the neural correlates of VMI vividness remain unclear, especially underlying different VMI types. Therefore, the current functional magnetic resonance imaging (fMRI) study aimed to investigate the neural mechanisms underlying static (SI) and dynamic VMI (DI), focusing on the role of precuneus especially in the imagery vividness.</p><p><strong>Methods: </strong>The study involved 24 participants recruited from ShanghaiTech University. After excluding four participants due to excessive movements, data from 20 participants were analyzed. Each participant completed the Chinese version of the Vividness of Visual Imagery Questionnaire (VVIQ) to assess their imagery vividness abilities. During fMRI scanning, participants were asked to imagine SI and DI scenarios in response to auditory stimuli. High-resolution fMRI data were acquired using a 3T scanner, and a General Linear Model (GLM) was applied to analyze blood oxygenation level-dependent (BOLD) signals, focusing on the precuneus's role in imagery vividness.</p><p><strong>Results: </strong>The results revealed that the left precuneus was found activated in both SI and DI tasks. Moreover, the left precuneus activation was positively correlated with VVIQ score. On the other hand, greater activation in the right precuneus was found during dynamic than static imagery as well as more extensive neural engagements; the right precuneus activation was further detected significantly correlated with individual VVIQ scores.</p><p><strong>Discussion: </strong>The study's findings offered fresh insights into the cognitive and neural processes subserving VMI. By revealing the distinct roles of the left and right precuneus in imagery vividness, this research contributed to a more nuanced understanding of VMI and its neural basis.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1516058"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined deep and reinforcement learning with gaming to promote healthcare in neurodevelopmental disorders: a new hypothesis.","authors":"Fabrizio Stasolla, Anna Passaro, Enza Curcio, Mariacarla Di Gioia, Antonio Zullo, Mirella Dragone, Elvira Martini","doi":"10.3389/fnhum.2025.1557826","DOIUrl":"10.3389/fnhum.2025.1557826","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1557826"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of four non-invasive stimulations on swallowing function and quality of life of stroke patients-a network meta-analysis.","authors":"Xinyu Lin, Haojie Li, Xie Wu, Rui Huang","doi":"10.3389/fnhum.2025.1519660","DOIUrl":"10.3389/fnhum.2025.1519660","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a sudden neurological disorder that causes severe neurological damage mainly due to lack of oxygen to brain cells as a result of interruption of blood flow to the brain. Dysphagia is a common problem in stroke patients, interfering with diet and nutrition and possibly leading to complications. About 50-80% of stroke patients experience dysphagia in the acute phase, which may lead to serious consequences such as aspiration and pneumonia. Therefore, improving swallowing function is essential to enhance patients' quality of life (QoL). Traditional rehab methods are limited, but non-invasive stimulation is safer and improves swallowing function through various mechanisms: pharyngeal electrical stimulation (PES) boosts cortical excitability and plasticity by stimulating pharyngeal nerves; neuro-muscular electrical stimulation (NmeS) enhances infrahyoid muscle strength and mobility with low-frequency pulses; repetitive transcranial magnetic stimulation (rTMS) promotes motor cortex remodeling; transcranial direct current stimulation (tDCS) increases neural activity in swallowing-related regions. These techniques are safe, easy to use, and show great potential for clinical application, needing further study.</p><p><strong>Methods: </strong>Six databases were systematically searched, and 17 randomized controlled trials with 788 stroke patients were finally included. The outcome indicators were swallowing function and QoL related indicators. Net meta-analysis was performed using Stata 17.0 to assess the relative effectiveness of each combined intervention and to test the consistency of direct and indirect evidence.</p><p><strong>Results: </strong>For swallowing function, rTMS [SMD = 5.10, 95% CI (3.20, 7.01), <i>p</i> < 0.0001, SUCRA = 87.3] showed the best results. For QoL, NmeS [SMD = 3.51, 95% CI (0.54, 6.47), <i>p</i> < 0.0001, SUCRA = 79.3] shows all its unique advantages.</p><p><strong>Conclusion: </strong>rTMS can effectively improve the swallowing function of stroke patients, while NmeS has the best effect in improving the QoL.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024603146.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1519660"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Dazzled by the mystery of mentalism: the cognitive neuroscience of mental athletes.","authors":"Andres Rieznik, Mikhail Lebedev, Mariano Sigman","doi":"10.3389/fnhum.2025.1569293","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1569293","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnhum.2017.00287.].</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1569293"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study comparing effects of infrared neuromodulation and transcranial magnetic stimulation using magnetic resonance imaging.","authors":"Sophia A Bibb, Emily J Yu, M Fiona Molloy, John LaRocco, Patricia Resnick, Kevin Reeves, K Luan Phan, Sanjay Krishna, Zeynep M Saygin","doi":"10.3389/fnhum.2025.1514087","DOIUrl":"10.3389/fnhum.2025.1514087","url":null,"abstract":"<p><p>No prior work has directly compared the impacts of transcranial photobiomodulation (tPBM) and transcranial magnetic stimulation (TMS) on the human brain. This within-subjects pilot study compares the effects of tPBM and TMS of human somatomotor cortex on brain structural and functional connectivity. Eight healthy participants underwent four lab visits each, each visit consisting of a pre-stimulation MRI, stimulation or sham, and a post-stimulation MRI, respectively. Stimulation and sham sessions were counterbalanced across subjects. Collected measures included structural MRI data, functional MRI data from a finger-tapping task, resting state functional connectivity, and structural connectivity. Analyses indicated increased activation of the left somatomotor region during a right-hand finger-tapping task following both tPBM and TMS. Additionally, trending increases in left-lateralized functional and structural connectivity from M1 to thalamus were observed after tPBM, but not TMS. Thus, tPBM may be superior to TMS at inducing changes in connected nodes in the somatomotor cortex, although further research is warranted to explore the potential therapeutic benefits and clinical utility of tPBM.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1514087"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}