Frontiers in Human Neuroscience最新文献

{"title":"Olfactory neurofeedback: current state and possibilities for further development.","authors":"Ivan Ninenko, Alexandra Medvedeva, Victoria L Efimova, Daria F Kleeva, Marina Morozova, Mikhail A Lebedev","doi":"10.3389/fnhum.2024.1419552","DOIUrl":"10.3389/fnhum.2024.1419552","url":null,"abstract":"<p><p>This perspective considers the novel concept of olfactory neurofeedback (O-NFB) within the framework of brain-computer interfaces (BCIs), where olfactory stimuli are integrated in various BCI control loops. In particular, electroencephalography (EEG)-based O-NFB systems are capable of incorporating different components of complex olfactory processing - from simple discrimination tasks to using olfactory stimuli for rehabilitation of neurological disorders. In our own work, EEG theta and alpha rhythms were probed as control variables for O-NFB. Additionaly, we developed an olfactory-based instructed-delay task. We suggest that the unique functions of olfaction offer numerous medical and consumer applications where O-NFB is combined with sensory inputs of other modalities within a BCI framework to engage brain plasticity. We discuss the ways O-NFB could be implemented, including the integration of different types of olfactory displays in the experiment set-up and EEG features to be utilized. We emphasize the importance of synchronizing O-NFB with respiratory rhythms, which are known to influence EEG patterns and cognitive processing. Overall, we expect that O-NFB systems will contribute to both practical applications in the clinical world and the basic neuroscience of olfaction.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1419552"},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structure and function differences across varying levels of endurance training: a cross-sectional study.","authors":"Keying Zhang, Chunmei Cao, Yaxue Wang, Dong Zhang","doi":"10.3389/fnhum.2024.1503094","DOIUrl":"10.3389/fnhum.2024.1503094","url":null,"abstract":"<p><strong>Background: </strong>Although previous studies have shown that athletes engaged in endurance sports exhibit unique characteristics of brain plasticity, there has been no systematic investigation into the structural and functional brain characteristics of endurance athletes with varying training levels.</p><p><strong>Methods: </strong>Utilizing the \"expert-novice paradigm\" design, we employed functional magnetic resonance imaging (fMRI) to obtain images of brain structure and functional activity. We compared differences in gray matter volume (GMV), fractional amplitude of low-frequency fluctuations (fALFF), and degree centrality (DC) among high-level endurance athletes, moderate-level endurance athletes, and non-athlete controls.</p><p><strong>Results: </strong>(1) High-level endurance athletes exhibited significantly greater GMV in the left parahippocampal gyrus, bilateral thalamus, right temporal lobe, and bilateral cerebellum compared to both moderate-level endurance athletes and controls. The GMV in these regions showed an increasing trend with more years of endurance training and higher endurance capacity. Additionally, these athletes had significantly higher fALFF in the left superior medial frontal gyrus and right precuneus, as well as higher DC in the right lateral occipital lobe compared to moderate-level endurance athletes. They also had significantly higher DC in the right precuneus and cerebellum compared to the control group. (2) Moderate-level endurance athletes demonstrated significantly greater GMV in the right prefrontal cortex, bilateral medial frontal lobe, right temporal pole, right striatum, and bilateral insula compared to high-level endurance athletes. They also had significantly higher fALFF in the left posterior cingulate gyrus compared to high-level endurance athletes. (3) Control group showed significantly greater GMV in the right amygdala, higher fALFF in the left medial frontal lobe, and greater DC in the left lateral occipital lobe compared to moderate-level endurance athletes.</p><p><strong>Conclusion: </strong>Adaptive benefits exhibit different characteristics across different endurance levels. High-level endurance athletes exhibit pronounced enhancements in gray matter volume and functional activity in regions associated with memory, motor control, and sensory processing. While moderate-level athletes demonstrate distinct functional reorganization in the default mode network and cerebellum.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1503094"},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and efficacy of applying a high-current temporal interference electrical stimulation in humans.","authors":"Yan Wang, Ginger Qinghong Zeng, Mengmeng Wang, Mingsong Zhang, Chuangchuang Chang, Qiongwei Liu, Keqing Wang, Ru Ma, Ying Wang, Xiaochu Zhang","doi":"10.3389/fnhum.2024.1484593","DOIUrl":"10.3389/fnhum.2024.1484593","url":null,"abstract":"<p><strong>Background: </strong>Temporal interference electrical stimulation (TI) is promise in targeting deep brain regions focally. However, limited electric field intensity challenges its efficacy.</p><p><strong>Objective: </strong>This study aimed to introduce a high-current TI electrical stimulation protocol to enhance its intensity and evaluate its safety and efficacy when applied to the primary motor cortex (M1) in the human brain.</p><p><strong>Methods: </strong>Safety assessments included a battery of biochemical and neuropsychological tests (NSE, MoCA, PPT, VAMS-R, and SAS measurements), 5-min resting-state electroencephalography (EEG) recordings before and after 30-min high-current TI electrical stimulation sessions (20 Hz, 70 Hz, sham). Adverse reactions were also documented post-stimulation. Efficacy evaluations involved two motor tasks, the simple reaction time (SRT) task and the one-increment task, to investigate the distinct contributions of beta (20 Hz) and gamma (70 Hz) oscillations to motor functions.</p><p><strong>Results: </strong>Biochemical and neuropsychological tests revealed no significant differences between the groups. Additionally, no epileptic activities were detected in the EEG recordings. In the one-increment task, 20 Hz stimulation delayed participants' reaction time compared to the 70 Hz and sham groups. Conversely, in the SRT task, 70 Hz stimulation exhibited a tendency to enhance participants' performance relative to the sham group.</p><p><strong>Conclusion: </strong>The proposed high-current TI electrical stimulation is both safe and effective for stimulating the human brain. Moreover, the distinct effects observed in motor tasks underscore the dissociative roles of beta and gamma oscillations in motor functions, offering valuable insights into the potential applications of high-current TI electrical stimulation in brain stimulation research.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1484593"},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mirrors and toothaches: commonplace manipulations of non-auditory feedback availability change perceived speech intelligibility.","authors":"Elizabeth D Casserly, Francesca R Marino","doi":"10.3389/fnhum.2024.1462922","DOIUrl":"10.3389/fnhum.2024.1462922","url":null,"abstract":"<p><p>This paper investigates the impact of two non-technical speech feedback perturbations outside the auditory modality: topical application of commercially-available benzocaine to reduce somatosensory feedback from speakers' lips and tongue tip, and the presence of a mirror to provide fully-detailed visual self-feedback. In experiment 1, speakers were recorded under normal quiet conditions (i.e., baseline), then again with benzocaine application plus auditory degradation, and finally with the addition of mirror feedback. Speech produced under normal and both feedback-altered conditions was assessed via naïve listeners' intelligibility discrimination judgments. Listeners judged speech produced under bisensory degradation to be less intelligible than speech from the un-degraded baseline, and with a greater degree of difference than previously observed with auditory-only degradation. The introduction of mirror feedback, however, did not result in relative improvements in intelligibility. Experiment 2, therefore, assessed the effect of a mirror on speech intelligibility in isolation with no other sensory feedback manipulations. Speech was recorded at baseline and then again in front of a mirror, and relative intelligibility was discriminated by naïve listeners. Speech produced with mirror feedback was judged as less intelligible than baseline tokens, indicating a negative impact of visual self-feedback in the absence of other sensory manipulations. The results of both experiments demonstrate that relatively accessible manipulations of non-auditory sensory feedback can produce speech-relevant effects, and that those effects are perceptible to naïve listeners.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1462922"},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25-year neuroimaging research on spoken language processing: a bibliometric analysis.","authors":"Yuxuan Zheng, Boning Zhang","doi":"10.3389/fnhum.2024.1461505","DOIUrl":"10.3389/fnhum.2024.1461505","url":null,"abstract":"<p><strong>Introduction: </strong>Spoken language processing is of huge interest to cognitive and neural scientists, as it is the dominant channel for everyday verbal communication. The aim of this study is to depict the dynamics of publications in the field of neuroimaging research on spoken language processing between 2000 and 2024.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted to probe this particular subject matter based on data retrieved from Web of Science. A total of 8,085 articles were found, which were analyzed together with their authors, journals of publication, citations and countries of origin.</p><p><strong>Results: </strong>Results showed a steady increase of publication volume and a relatively high academic visibility of this research field indexed by total citations in the first 25 years of the 21st century. Maps of frequent keywords, institutional collaboration network show that cooperations mainly happen between institutions in the United States, the United Kingdom and Germany. Future trends based on burst detection predict that classification, Alzheimer's disease and oscillations are potential hot topics.</p><p><strong>Discussion: </strong>Possible reasons for the result include the aging of the population in developed countries, and the rapid growth of artificial intelligence in the past decade. Finally, specific research avenues were proposed which might benefit future studies.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1461505"},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of <i>ex vivo</i> formalin-fixed human brainstem-cerebellum complex.","authors":"Sahin Hanalioglu, Siyar Bahadir, Ahmet C Ozak, Kivanc Yangi, Giancarlo Mignucci-Jiménez, Muhammet Enes Gurses, Alberto Fuentes, Ethan Mathew, Dakota T Graham, Muhammed Yakup Altug, Egemen Gok, Gregory H Turner, Michael T Lawton, Mark C Preul","doi":"10.3389/fnhum.2024.1484431","DOIUrl":"10.3389/fnhum.2024.1484431","url":null,"abstract":"<p><strong>Introduction: </strong>Brain cross-sectional images, tractography, and segmentation are valuable resources for neuroanatomical education and research but are also crucial for neurosurgical planning that may improve outcomes in cerebellar and brainstem interventions. Although ultrahigh-resolution 7-Tesla (7T) magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) reveal such structural brain details in living or fresh unpreserved brain tissue, imaging standard formalin-preserved cadaveric brain specimens often used for neurosurgical anatomic studies has proven difficult. This study sought to develop a practical protocol to provide anatomic information and tractography results of an <i>ex vivo</i> human brainstem-cerebellum specimen.</p><p><strong>Materials and methods: </strong>A protocol was developed for specimen preparation and 7T MRI with image postprocessing on a combined brainstem-cerebellum specimen obtained from an 85-year-old male cadaver with a postmortem interval of 1 week that was stored in formalin for 6 months. Anatomic image series were acquired for detailed views and diffusion tractography to map neural pathways and segment major anatomic structures within the brainstem and cerebellum.</p><p><strong>Results: </strong>Complex white matter tracts were visualized with high-precision segmentation of crucial brainstem structures, delineating the brainstem-cerebellum and mesencephalic-dentate connectivity, including the Guillain-Mollaret triangle. Tractography and fractional anisotropy mapping revealed the complexities of white matter fiber pathways, including the superior, middle, and inferior cerebellar peduncles and visible decussating fibers. 3-dimensional (3D) reconstruction and quantitative and qualitative analyses verified the anatomical precision of the imaging relative to a standard brain space.</p><p><strong>Discussion: </strong>This novel imaging protocol successfully captured the intricate 3D architecture of the brainstem-cerebellum network. The protocol, unique in several respects (including tissue preservation and rehydration times, choice of solutions, preferred sequences, voxel sizes, and diffusion directions) aimed to balance high resolution and practical scan times. This approach provided detailed neuroanatomical imaging while avoiding impractically long scan times. The extended postmortem and fixation intervals did not compromise the diffusion imaging quality. Moreover, the combination of time efficiency and ultrahigh-resolution imaging results makes this protocol a strong candidate for optimal use in detailed neuroanatomical studies, particularly in presurgical trajectory planning.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1484431"},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquisition of a new language: an <i>enriched</i> case study documents language growth without external input in a young Korean child's acquisition of English.","authors":"Barbara Lust, Suzanne Flynn, Ahyoung Alicia Kim","doi":"10.3389/fnhum.2024.1456054","DOIUrl":"10.3389/fnhum.2024.1456054","url":null,"abstract":"<p><p>This paper explores a case of suspension of data input during the acquisition of a second language by a young Korean child acquiring English in an English-only nursery school in the United States. Data suspension occurred naturally when the child returned to Korea for a summer where only Korean was spoken. Systematic investigations using an enriched case study methodology which assessed the nature of the child's English target language acquisition both before and after the Korean Summer revealed significant advances in his English after the Korean Summer despite the absence of English input during this time. Several hypotheses regarding the nature and explanation of this advance are tested. It is argued that significant internal linguistic integration leading to systematization of linguistic knowledge occurred in the absence of synchronous language data input, demonstrating the significance of internal computational processes over and above language data input in the language acquisition process. Results have implications for understanding the fundamental nature of language acquisition.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1456054"},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hiding in plain sight: children with visual perceptual difficulties in schools.","authors":"Nicola McDowell, Helen St Clair Tracy, Andrew Blaikie, John Ravenscroft, Gordon N Dutton","doi":"10.3389/fnhum.2024.1496730","DOIUrl":"https://doi.org/10.3389/fnhum.2024.1496730","url":null,"abstract":"<p><p>Cerebral visual impairment (CVI) is increasingly being recognized as a significant cause of visual difficulties in children, particularly those with typical visual acuity, who nonetheless struggle in educational settings. This narrative review aims to elucidate the nature and impact of visual perceptual difficulties (VPD) associated with CVI in school-aged children, who often remain undiagnosed due to the current erroneous focus on visual acuity as a required diagnostic criterion for CVI. The review synthesizes findings from recent studies, highlighting that up to 3.4% of children in mainstream schools and a higher percentage in special educational settings may experience VPD, which significantly impacts upon their learning and development. The manifestations of VPDs, such as difficulties in motion perception, recognition, and visuospatial processing, are often subtle and can thus be overlooked, leading to misconceptions about the origins of the affected child's abilities and behaviors. The review also discusses the challenges in current diagnostic processes, emphasizing the need for comprehensive history taking and assessments that go beyond standard visual acuity tests. It proposes a multi-faceted approach to identification and support, incorporating both clinical assessments and teacher/parental observations, to better address the needs of affected children. Furthermore, this paper advocates for the inclusion of VPDs in the International Classification of Diseases (ICD 11) to ensure children with these visual issues receive appropriate educational support. By integrating lived experiences of individuals with CVI and the latest research findings, this review underscores the urgent need for awareness and tailored educational strategies designed to support children with VPDs. The findings suggest that without such recognition and intervention, many children with VPDs will continue to \"hide in plain sight,\" facing unnecessary challenges in their educational and social development. The review concludes with recommendations for policy changes and future research directions to improve the identification, classification, and support of children with VPDs within the educational system.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1496730"},"PeriodicalIF":2.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Imagination, cognition, and the arts.","authors":"Víctor Bermúdez, Renata Gambino, Benito García-Valero, Grazia Pulvirenti","doi":"10.3389/fnhum.2024.1523760","DOIUrl":"https://doi.org/10.3389/fnhum.2024.1523760","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1523760"},"PeriodicalIF":2.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four-class ASME BCI: investigation of the feasibility and comparison of two strategies for multiclassing.","authors":"Simon Kojima, Shin'ichiro Kanoh","doi":"10.3389/fnhum.2024.1461960","DOIUrl":"10.3389/fnhum.2024.1461960","url":null,"abstract":"<p><strong>Introduction: </strong>The ASME (stands for Auditory Stream segregation Multiclass ERP) paradigm is proposed and used for an auditory brain-computer interface (BCI). In this paradigm, a sequence of sounds that are perceived as multiple auditory streams are presented simultaneously, and each stream is an oddball sequence. The users are requested to focus selectively on deviant stimuli in one of the streams, and the target of the user attention is detected by decoding event-related potentials (ERPs). To achieve multiclass ASME BCI, the number of streams must be increased. However, increasing the number of streams is not easy because of a person's limited audible frequency range. One method to achieve multiclass ASME with a limited number of streams is to increase the target stimuli in a single stream.</p><p><strong>Methods: </strong>Two approaches for the ASME paradigm, ASME-4stream (four streams with a single target stimulus in each stream) and ASME-2stream (two streams with two target stimuli in each stream) were investigated. Fifteen healthy subjects with no neurological disorders participated in this study. An electroencephalogram was acquired, and ERPs were analyzed. The binary classification and BCI simulation (detecting the target class of the trial out of four) were conducted with the help of linear discriminant analysis, and its performance was evaluated offline. Its usability and workload were also evaluated using a questionnaire.</p><p><strong>Results: </strong>Discriminative ERPs were elicited in both paradigms. The average accuracies of the BCI simulations were 0.83 (ASME-4stream) and 0.86 (ASME-2stream). In the ASME-2stream paradigm, the latency and the amplitude of P300 were shorter and larger, the average binary classification accuracy was higher, and the average weighted workload was smaller.</p><p><strong>Discussion: </strong>Both four-class ASME paradigms achieved a sufficiently high accuracy (over 80%). The shorter latency and larger amplitude of P300 and the smaller workload indicated that subjects could perform the task confidently and had high usability in ASME-2stream compared to ASME-4stream paradigm. A paradigm with multiple target stimuli in a single stream could create a multiclass ASME BCI with limited streams while maintaining task difficulty. These findings expand the potential for an ASME BCI multiclass extension, offering practical auditory BCI choices for users.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1461960"},"PeriodicalIF":2.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}