Frontiers in Human Neuroscience最新文献

{"title":"Transcutaneous and transcranial electrical stimulation for enhancing military performance: an update and systematic review.","authors":"Onno van der Groen, Sara A Rafique, Nick Willmot, Margaret G Murphy, Eulalia Tisnovsky, Tad T Brunyé","doi":"10.3389/fnhum.2025.1501209","DOIUrl":"10.3389/fnhum.2025.1501209","url":null,"abstract":"<p><strong>Introduction: </strong>Electrical stimulation (ES), including transcranial electrical stimulation (tES) and transcutaneous vagus nerve stimulation (tVNS), has shown potential for cognitive enhancement in military contexts. Various types of ES, such as transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), modulate neuronal membrane potentials and cortical excitability, potentially improving cognitive functions relevant to military training and operations.</p><p><strong>Methods: </strong>This systematic review updates previous findings by examining studies published between 2019 and 2024 that investigated electrical stimulation effects on cognitive performance in military personnel and tasks. We focused on whether the studies addressed key questions about the generalizability of lab findings to military tasks, the frequency and intensity of adverse effects, the impact of repeated ES administration, and the ethical and regulatory considerations for its use in potentially vulnerable military populations.</p><p><strong>Results: </strong>Eleven studies met the inclusion criteria; most demonstrated overall low to some concerns, however, two of these had overall high risk of bias. While tES and tVNS showed some promise for enhancing multitasking and visual search performance, the results were mixed, with no reliable effects on vigilance tasks.</p><p><strong>Discussion: </strong>The reviewed studies highlight the need for a better understanding of ES mechanisms, optimal stimulation parameters, and individual differences in response to ES. They also highlight the importance of conducting high-powered research in military settings to evaluate the efficacy, safety, and ethical implications of ES. Future research should address the generalizability of lab-based results to real-world military tasks, monitor the frequency and intensity of adverse effects, and explore the long-term impacts of repeated administration. Furthermore, ethical and regulatory considerations are crucial for the responsible application of ES in military contexts, and a series of outstanding questions is posed to guide continuing research in this domain.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1501209"},"PeriodicalIF":2.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological approaches for managing pain in multiple sclerosis: a mini review.","authors":"Samar S Ayache, Moussa A Chalah","doi":"10.3389/fnhum.2025.1552435","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1552435","url":null,"abstract":"<p><p>Chronic pain is a prevalent yet often under-recognized symptom among individuals with multiple sclerosis (MS), affecting 29-86% of the population. This condition can significantly impact the individuals' functionality, including their capacity to engage in professional activities. The pathophysiology underlying this condition remains intricate and not fully elucidated, and inadequate responses to pharmacological interventions or adverse effects can hinder its management. In light of these observations, there is an urgent need to identify new therapeutic interventions. Non-invasive brain stimulation (NIBS) techniques hold promise for addressing MS-related pain. This mini-review aims to analyze the findings from studies using NIBS techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), to assess their analgesic potential in people with MS. Seven relevant reports are available. Five of these studies used tDCS, one utilized a transcranial random noise stimulation (tDCS variant), and one compared rTMS with transcranial theta burst stimulation (rTMS variant). The results indicate the potential benefits of NIBS for pain management in MS. However, the study's limitations, including the scarcity of data, small sample size, the limited number of sessions, sham design, and brief follow-up, are also noted and discussed. Finally, directions for future research are suggested.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1552435"},"PeriodicalIF":2.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study.","authors":"Roberto U Cofresí, Spencer Upton, Devon Terry, Alexander A Brown, Thomas M Piasecki, Bruce D Bartholow, Brett Froeliger","doi":"10.3389/fnhum.2025.1557661","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1557661","url":null,"abstract":"<p><strong>Introduction: </strong>Lower sensitivity (LS) to acute alcohol promotes hazardous alcohol use, increasing risk for alcohol use disorder (AUD). Compared to peers with high sensitivity (HS), LS individuals exhibit amplified responses to alcohol cues and difficulty exerting inhibitory control (IC) over those cued responses. However, it is unclear whether LS and HS individuals differ in neural or behavioral responses when exerting IC over affectively neutral prepotent responses (i.e., domain-general IC). This fMRI pilot study examined domain-general IC and its neural correlates in young adult LS and HS individuals.</p><p><strong>Methods: </strong>Participants (<i>N</i> = 32, M _<i>age</i> = 20.3) were recruited based on their Alcohol Sensitivity Questionnaire responses (HS: <i>n</i> = 16; LS: <i>n</i> = 16; 9 females/group) to complete an event-related fMRI IC task in a sober state. Retrospective assessments of alcohol craving, consumption, and problems were taken outside the lab.</p><p><strong>Results: </strong>Although IC performance (accuracy) was numerically lower for the LS group (M[SD] = 0.527[0.125]) compared to the HS group (M[SD] = 0.595[0.124]), no significant difference was detected [<i>t</i>(30) = 1.55, <i>p</i> = 0.132]. Across groups, IC-related activity was observed in bilateral fronto-cortico-striatal circuitry, including dorsal striatum (DS) and dorsal/supragenual anterior cingulate cortex (dACC). Within group HS, IC-related dACC activity was greater among individuals reporting less intense (b-95 CI = [-0.201, -0.041], <i>p</i> = 0.004) and less frequent alcohol craving experiences (b-95 CI = [-0.131, 0.005], <i>p</i> = 0.068), whereas in group LS, IC-related dACC activity was greater among individuals reporting more intense (b-95 CI = [0.009, 0.140], <i>p</i> = 0.028) and more frequent alcohol craving experiences (b-95 CI = [0.022, 0.128], <i>p</i> = 0.007).</p><p><strong>Discussion: </strong>In sum, while LS and HS individuals demonstrated similar domain-general IC performance and recruited similar neural resources to perform IC, findings suggest that compensatory over-activation of frontocortical nodes of the fronto-cortico-striatal IC circuitry may be related to affective-motivational aspects of AUD symptomatology (craving in daily life) among LS individuals. Based on these preliminary findings, future studies with larger samples are warranted to determine the extent to which domain-general IC performance associated with fronto-cortico-striatal IC circuit activation contributes to the alcohol use pathophysiology, and whether therapeutic interventions (e.g., non-invasive brain stimulation) targeting fronto-cortico-striatal IC circuitry may decrease AUD symptomatology.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1557661"},"PeriodicalIF":2.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study on the effect of aerobic exercise intervention on the inhibitory control in college students with internet addiction.","authors":"Yi Wang, Xiangkun Li","doi":"10.3389/fnhum.2025.1500399","DOIUrl":"10.3389/fnhum.2025.1500399","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the effects of aerobic exercise on reactive inhibitory control in college students with internet addiction, examining both behavioral and electrophysiological changes over time.</p><p><strong>Methods: </strong>A longitudinal study design was adopted, involving 48 male college students with internet addiction who were randomly assigned to either a control group or an experimental group. Participants in the experimental group engaged in 40 min aerobic cycling sessions three times per week for 12 weeks, while the control group maintained their usual physical activity levels without any intervention. A 3 × 2 × 3 mixed-factorial design was utilized, incorporating three time points (pre-experiment, 6 and 12 weeks), two groups (control and experimental), and three electrode sites (Fz, F3, F4). This design enabled the examination of the effects of aerobic exercise on reactive inhibitory control and its temporal dynamics in college students with internet addiction.</p><p><strong>Results: </strong>A significant main effect of group was observed. Specifically, the experimental group demonstrated a significantly higher Nogo accuracy rate compared to the control group at both the mid-test (<i>P</i> < 0.01) and post-test (<i>P</i> < 0.001). Within the experimental group, the Nogo accuracy rate at the mid-test and post-test was significantly higher than at the pre-test (<i>P</i> < 0.001), with the post-test accuracy rate also significantly higher than the mid-test (P < 0.05). Time-frequency analysis revealed that, under the Nogo task, the energy values in the beta frequency band during the early (100-500 ms) and late (600-750 ms) time windows were significantly higher at the mid-test and post-test compared to the pre-test (<i>P</i> < 0.05), with the post-test values significantly exceeding those at the mid-test (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>(1) Moderate-intensity aerobic exercise significantly improves reactive inhibitory control in college students with internet addiction, with the magnitude of improvement increasing over the duration of the intervention. (2) Increased beta band energy during the early (100-500 ms) and late (600-750 ms) time windows serve as a key neurophysiological indicator of this enhancement.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1500399"},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphosyntactic production and processing skills in relation to age effects and lexical-phonological levels among children with cochlear implants and typically hearing peers: a focus on vowel nasality.","authors":"Sophie Fagniart, Brigitte Charlier, Véronique Delvaux, Bernard Georges Harmegnies, Anne Huberlant, Myriam Piccaluga, Kathy Huet","doi":"10.3389/fnhum.2025.1528388","DOIUrl":"10.3389/fnhum.2025.1528388","url":null,"abstract":"<p><strong>Introduction: </strong>Significant variability in the language performance of children with cochlear implant (CI) is widely recognized in the literature, particularly concerning morphosyntactic (MS) skills. The perceptual limitations of the CI, which can lead to phonological difficulties, may be responsible for this increased vulnerability in grammatical abilities. In this context, the present study focuses on the morphophonemic processing of items distinguished by nasal and oral vowels in the French language - the feature of vowel nasality being known as challenging for the CI population. Links between these performances with chronological/auditory ages and phonological and grammatical production skills will also be explored.</p><p><strong>Method: </strong>Nineteen children with CIs and 47 children with typical hearing (TH) were assessed for phonological skills through a picture-naming task, perceptual skills through a task involving the sentence/word-picture matching task with word target containing nasal vs. oral vowels, and morphosyntactic production skills through narrative productions. Various measures of linguistic complexity [Mean Length of Utterance (MLU), verbs/utterances (V/U)] and lexical diversity (D index) were evaluated among our groups and linked to perceptual and productive phonological performances. Chronological and auditory ages as well as phonological accuracy and vocabulary levels as been studied as covariates.</p><p><strong>Results: </strong>Children with CIs displayed significantly lower morphosyntactic (MS) performance compared to peers with TH of the same chronological age, particularly in measures such as MLU in morphemes, complexity of function words, and processing of morphemes carried by nasal and oral vowels. However, when controlling for auditory age or phonological/lexical levels, these differences were no longer significant, suggesting a potential for compensation when similar auditory or linguistic experiences are achieved. Despite this, CI users showed distinct patterns of function word use, with fewer complex forms and more frequent errors, likely reflecting the perceptual challenges linked to CI. Additionally, a specific strong relationship between MS skills and phonological accuracy was observed in the CI group, potentially accounting for the marked inter-individual variability in MS development.</p><p><strong>Conclusion: </strong>The perceptual limitations of the CI have a significant impact on the linguistic development of children with CI and contribute to the widely documented variability in performance.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1528388"},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A spatial and temporal transformer-based EEG emotion recognition in VR environment.","authors":"Ming Li, Peng Yu, Yang Shen","doi":"10.3389/fnhum.2025.1517273","DOIUrl":"10.3389/fnhum.2025.1517273","url":null,"abstract":"<p><p>With the rapid development of deep learning, Electroencephalograph(EEG) emotion recognition has played a significant role in affective brain-computer interfaces. Many advanced emotion recognition models have achieved excellent results. However, current research is mostly conducted in laboratory settings for emotion induction, which lacks sufficient ecological validity and differs significantly from real-world scenarios. Moreover, emotion recognition models are typically trained and tested on datasets collected in laboratory environments, with little validation of their effectiveness in real-world situations. VR, providing a highly immersive and realistic experience, is an ideal tool for emotional research. In this paper, we collect EEG data from participants while they watched VR videos. We propose a purely Transformer-based method, EmoSTT. We use two separate Transformer modules to comprehensively model the temporal and spatial information of EEG signals. We validate the effectiveness of EmoSTT on a passive paradigm collected in a laboratory environment and an active paradigm emotion dataset collected in a VR environment. Compared with state-of-the-art methods, our method achieves robust emotion classification performance and can be well transferred between different emotion elicitation paradigms.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1517273"},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of upper limb muscle activation in the frequency domain in wheelchair fencers.","authors":"Monika Błaszczyszyn, Katarzyna Piechota, Zbigniew Borysiuk, Krzysztof Kręcisz, Dariusz Zmarzły","doi":"10.3389/fnhum.2025.1523358","DOIUrl":"10.3389/fnhum.2025.1523358","url":null,"abstract":"<p><strong>Background: </strong>The study includes a correlation analysis of EMG signals of upper limb muscle activity in wheelchair fencers. The aim of the study was to investigate neuromuscular conduction in wheelchair fencers using the EMG signal from their upper limb muscles.</p><p><strong>Methods: </strong>Wavelet transform analysis was used to examine the biosignals. The recorded EMG signals were subjected to time-frequency transformations. The scalograms were determined using the continuous wavelet transform. Based on the analysis, time-frequency coherence maps were extracted to determine validation in the frequency bands: 2-16 Hz, 17-30 Hz, and 31-60 Hz. The study participants were 16 wheelchair fencers, members of the Polish Paralympic Team, in two disability categories: 7 in category A and 9 in category B. Coherence was calculated for frequencies up to 60 Hz.</p><p><strong>Results: </strong>The analysis revealed the individual time-dependent coherence between two signals for different frequencies during the work cycle of the antagonist muscles of the arm (biceps/triceps) and forearm (flexor/extensor carpi radialis). A significant difference in alpha coherence (2-16 Hz) occurred in the group of forearm muscles in the frequency band of 2-16 Hz, both for G (<i>p</i> = 0.042) and M (<i>p</i> = 0.031) parameters (G: A - 0.08 Hz, B - 0.04 Hz; M: A - 0.51 and B - 0.42). Its peaks were observed during the fencing action cycle. Some differences in gamma coherence were also found in the EMG signals of the forearm muscles in the 31-60 Hz frequency band were statistically significant (<i>p</i> = 0.031): 0.43 in group A and 0.36 in group B.</p><p><strong>Conclusion: </strong>The results showed the neuromuscular conduction, where alpha coherence reflects the reticulospinal tract responsible for the excitation of the distal muscles of the wrist and hand, while gamma coherence results from cortical signals. It is related to efferent conduction and reflects corticomuscular coupling. Frequency domain coherence analysis determines the strength of intermuscular synchronization, allowing a comprehensive investigation of the neural mechanisms underlying motor recovery. It maps separate neural pathways for arm and hand control.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1523358"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of physiological changes associated with single-session pre-frontal tDCS: a pilot study.","authors":"Hannah N Rembrandt, Ellyn A Riley","doi":"10.3389/fnhum.2025.1549248","DOIUrl":"10.3389/fnhum.2025.1549248","url":null,"abstract":"<p><strong>Objective: </strong>Transcranial direct current stimulation (tDCS), a non-invasive, painless method of applying direct current electrical stimulation to specific areas of the brain, is an effective method for enhancing attention and post-stroke fatigue, as shown by behavioral improvements in post-stroke populations. While behavioral evidence supports this method, there is a paucity of physiological data corroboration of this improvement. The current study is designed to investigate if a single session of tDCS will improve attention and fatigue as shown by relevant physiological methods in persons with post-stroke aphasia.</p><p><strong>Methods: </strong>Ten participants (5 male; mean age: 62.8) engaged in two identically structured data collection sessions with at least a 3-day wash-out period between them. Sessions started with a sustained attention task with simultaneous electroencephalography (EEG) and pupillometry data collection, followed by an attention training program with simultaneous active or sham tDCS. Following tDCS, participants repeated the sustained attention task with simultaneous EEG and pupillometry data collection. Participants received active tDCS during one session, and sham tDCS during the other, with the order randomized.</p><p><strong>Results: </strong>No differences between conditions were found for either behavioral results from the sustained attention task (i.e., reaction time of correct responses; <i>n</i> = 9 <i>p</i> = 0.39) or EEG measured attention state data for any of the four attention states: no attention (<i>n</i> = 10, <i>p</i> = 0.83), distracted attention (<i>n</i> = 10, <i>p</i> = 0.20), moderate attention (<i>n</i> = 10, <i>p</i> = 0.95), or high attention (<i>n</i> = 10, <i>p</i> = 0.62). Pupil dilation was significantly greater in the post-active tDCS stimulation condition than in either pre-training condition (<i>n</i> = 10, <i>p</i> < 0.01). tDCS stimulation lessened the increase in task-based fatigue from the beginning to the end of the session such that there was a significant increase in task-based fatigue when participants received sham tDCS (<i>n</i> = 10, <i>p</i> = 0.01) but no significant change in task-based fatigue during the active condition session (<i>n</i> = 10, <i>p</i> = 0.12).</p><p><strong>Conclusion: </strong>Changes in pupil diameter observed in the active stimulation condition suggest activation of the locus coeruleus-norepinephrine (LC-NE) pathway within a single session of tDCS administration, but the lack of significant changes for either response time or attention states indicate no direct effect on behaviorally measured or EEG measured attention within the same timeframe. Responses to active stimulation in terms of subjective fatigue rating varied between individual participants; overall, active tDCS mitigated task-based fatigue. More research is needed to investigate this relationship.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1549248"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.","authors":"Alfonso Enrique Martinez-Nunez, Christopher J Rozell, Simon Little, Huiling Tan, Stephen L Schmidt, Warren M Grill, Miroslav Pajic, Dennis A Turner, Coralie de Hemptinne, Andre Machado, Nicholas Schiff, Abbey S Holt-Becker, Robert S Raike, Mahsa Malekmohammadi, Yagna J Pathak, Lyndahl Himes, David Greene, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Jacob Robinson, Bahne H Bahners, Vladimir Litvak, Luka Milosevic, Saadi Ghatan, Frederic L W V J Schaper, Michael D Fox, Nicholas M Gregg, Cynthia Kubu, James J Jordano, Nicola G Cascella, YoungHoon Nho, Casey H Halpern, Helen S Mayberg, Ki Sueng Choi, Haneul Song, Jungho Cha, Sankar Alagapan, Nico U F Dosenbach, Evan M Gordon, Jianxun Ren, Hesheng Liu, Lorraine V Kalia, Dorian Kusyk, Adolfo Ramirez-Zamora, Kelly D Foote, Michael S Okun, Joshua K Wong","doi":"10.3389/fnhum.2025.1544994","DOIUrl":"10.3389/fnhum.2025.1544994","url":null,"abstract":"<p><p>The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson's disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for patients with treatment-resistant symptoms. We estimate that 300,000 leads have been implanted to date for neurologic and neuropsychiatric indications. Magnetoencephalography has provided insights into the post-DBS physiological changes. The field is also critically examining the ethical implications of implants, considering the long-term impacts on clinicians, patients, and manufacturers.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1544994"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low doses of cannabis extract ameliorate non-motor symptoms of Parkinson's disease patients: a case series.","authors":"Ana Carolina Ruver-Martins, Ingrid Andrea Rodriguez Martinez, Vinicius Giesel Holla, Beatriz Larentis de Souza, Elton Gomes da Silva, Diana Marcela Aragon Novoa, Eduardo Souza-Silva, Fabiano Soares Araujo, Rui Daniel Prediger, Francisney Pinto do Nascimento","doi":"10.3389/fnhum.2024.1466438","DOIUrl":"10.3389/fnhum.2024.1466438","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1466438"},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}