Frontiers in Neural Circuits最新文献_第9页

Cross-species conservation in the regulation of parvalbumin by perineuronal nets 神经元周围网对副白蛋白的跨物种调控保护

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-11-29 DOI: 10.3389/fncir.2023.1297643

Angela S. Wang, Xinghaoyun Wan, Daria-Salina Storch, Vivian Y. Li, Gilles Cornez, Jacques Balthazart, J. Miguel Cisneros-Franco, Etienne de Villers-Sidani, Jon T. Sakata

{"title":"Cross-species conservation in the regulation of parvalbumin by perineuronal nets","authors":"Angela S. Wang, Xinghaoyun Wan, Daria-Salina Storch, Vivian Y. Li, Gilles Cornez, Jacques Balthazart, J. Miguel Cisneros-Franco, Etienne de Villers-Sidani, Jon T. Sakata","doi":"10.3389/fncir.2023.1297643","DOIUrl":"https://doi.org/10.3389/fncir.2023.1297643","url":null,"abstract":"Parvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity. Therefore, understanding the factors that regulate PV expression is important for revealing modulators of brain function. While the contribution of PV neurons to neural processes has been studied in mammals, relatively little is known about PV function in non-mammalian species, and discerning similarities in the regulation of PV across species can provide insight into evolutionary conservation in the role of PV neurons. Here we investigated factors that affect the abundance of PV in PV neurons in sensory and motor circuits of songbirds and rodents. In particular, we examined the degree to which perineuronal nets (PNNs), extracellular matrices that preferentially surround PV neurons, modulate PV abundance as well as how the relationship between PV and PNN expression differs across brain areas and species and changes over development. We generally found that cortical PV neurons that are surrounded by PNNs (PV+PNN neurons) are more enriched with PV than PV neurons without PNNs (PV-PNN neurons) across both rodents and songbirds. Interestingly, the relationship between PV and PNN expression in the vocal portion of the basal ganglia of songbirds (Area X) differed from that in other areas, with PV+PNN neurons having lower PV expression compared to PV-PNN neurons. These relationships remained consistent across development in vocal motor circuits of the songbird brain. Finally, we discovered a causal contribution of PNNs to PV expression in songbirds because degradation of PNNs led to a diminution of PV expression in PV neurons. These findings reveal a conserved relationship between PV and PNN expression in sensory and motor cortices and across songbirds and rodents and suggest that PV neurons could modulate plasticity and neural dynamics in similar ways across songbirds and rodents.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"1 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do we all synch alike? Brain–body-environment interactions in ASD 我们都一样吗？ASD 的脑-体-环境相互作用

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-11-27 DOI: 10.3389/fncir.2023.1275896

Shlomit Beker, Sophie Molholm

{"title":"Do we all synch alike? Brain–body-environment interactions in ASD","authors":"Shlomit Beker, Sophie Molholm","doi":"10.3389/fncir.2023.1275896","DOIUrl":"https://doi.org/10.3389/fncir.2023.1275896","url":null,"abstract":"Autism Spectrum Disorder (ASD) is characterized by rigidity of routines and restricted interests, and atypical social communication and interaction. Recent evidence for altered synchronization of neuro-oscillatory brain activity with regularities in the environment and of altered peripheral nervous system function in ASD present promising novel directions for studying pathophysiology and its relationship to ASD clinical phenotype. Human cognition and action are significantly influenced by physiological rhythmic processes that are generated by both the central nervous system (CNS) and the autonomic nervous system (ANS). Normally, perception occurs in a dynamic context, where brain oscillations and autonomic signals synchronize with external events to optimally receive temporally predictable rhythmic information, leading to improved performance. The recent findings on the time-sensitive coupling between the brain and the periphery in effective perception and successful social interactions in typically developed highlight studying the interactions within the brain–body-environment triad as a critical direction in the study of ASD. Here we offer a novel perspective of autism as a case where the temporal dynamics of brain–body-environment coupling is impaired. We present evidence from the literature to support the idea that in autism the nervous system fails to operate in an adaptive manner to synchronize with temporally predictable events in the environment to optimize perception and behavior. This framework could potentially lead to novel biomarkers of hallmark deficits in ASD such as cognitive rigidity and altered social interaction.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"314 5 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138819618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Marine invertebrates: neurons, glia, and neurotransmitters. 社论:海洋无脊椎动物:神经元、神经胶质和神经递质。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-11-14 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1327991

Tatiana N Olivares-Bañuelos, Arturo Ortega

引用次数: 0

Acetylcholine facilitates localized synaptic potentiation and location specific feature binding 乙酰胆碱促进局部突触增强和位置特异性特征结合

3区医学

Frontiers in Neural Circuits Pub Date : 2023-11-10 DOI: 10.3389/fncir.2023.1239096

Yihao Yang, Victoria Booth, Michal Zochowski

{"title":"Acetylcholine facilitates localized synaptic potentiation and location specific feature binding","authors":"Yihao Yang, Victoria Booth, Michal Zochowski","doi":"10.3389/fncir.2023.1239096","DOIUrl":"https://doi.org/10.3389/fncir.2023.1239096","url":null,"abstract":"Forebrain acetylcholine (ACh) signaling has been shown to drive attention and learning. Recent experimental evidence of spatially and temporally constrained cholinergic signaling has sparked interest to investigate how it facilitates stimulus-induced learning. We use biophysical excitatory-inhibitory (E-I) multi-module neural network models to show that external stimuli and ACh signaling can mediate spatially constrained synaptic potentiation patterns. The effects of ACh on neural excitability are simulated by varying the conductance of a muscarinic receptor-regulated hyperpolarizing slow K+ current (m-current). Each network module consists of an E-I network with local excitatory connectivity and global inhibitory connectivity. The modules are interconnected with plastic excitatory synaptic connections, that change via a spike-timing-dependent plasticity (STDP) rule. Our results indicate that spatially constrained ACh release influences the information flow represented by network dynamics resulting in selective reorganization of inter-module interactions. Moreover the information flow depends on the level of synchrony in the network. For highly synchronous networks, the more excitable module leads firing in the less excitable one resulting in strengthening of the outgoing connections from the former and weakening of its incoming synapses. For networks with more noisy firing patterns, activity in high ACh regions is prone to induce feedback firing of synchronous volleys and thus strengthening of the incoming synapses to the more excitable region and weakening of outgoing synapses. Overall, these results suggest that spatially and directionally specific plasticity patterns, as are presumed necessary for feature binding, can be mediated by spatially constrained ACh release.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":" 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135191494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: GABAergic circuits in health and disease. 编辑:gaba能回路在健康和疾病。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1322193

Lisa Topolnik, Graziella Di Cristo, Elsa Rossignol

引用次数: 0

The flow of axonal information among hippocampal sub-regions 2: patterned stimulation sharpens routing of information transmission 海马亚区之间的轴突信息流 2：模式化刺激使信息传输路线更加清晰

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-20 DOI: 10.3389/fncir.2023.1272925

Samuel Brandon Lassers, Yash S. Vakilna, William C. Tang, Gregory J. Brewer

{"title":"The flow of axonal information among hippocampal sub-regions 2: patterned stimulation sharpens routing of information transmission","authors":"Samuel Brandon Lassers, Yash S. Vakilna, William C. Tang, Gregory J. Brewer","doi":"10.3389/fncir.2023.1272925","DOIUrl":"https://doi.org/10.3389/fncir.2023.1272925","url":null,"abstract":"The sub-regions of the hippocampal formation are essential for episodic learning and memory formation, yet the spike dynamics of each region contributing to this function are poorly understood, in part because of a lack of access to the inter-regional communicating axons. Here, we reconstructed hippocampal networks confined to four subcompartments in 2D cultures on a multi-electrode array that monitors individual communicating axons. In our novel device, somal, and axonal activity was measured simultaneously with the ability to ascertain the direction and speed of information transmission. Each sub-region and inter-regional axons had unique power-law spiking dynamics, indicating differences in computational functions, with abundant axonal feedback. After stimulation, spiking, and burst rates decreased in all sub-regions, spikes per burst generally decreased, intraburst spike rates increased, and burst duration decreased, which were specific for each sub-region. These changes in spiking dynamics post-stimulation were found to occupy a narrow range, consistent with the maintenance of the network at a critical state. Functional connections between the sub-region neurons and communicating axons in our device revealed homeostatic network routing strategies post-stimulation in which spontaneous feedback activity was selectively decreased and balanced by decreased feed-forward activity. Post-stimulation, the number of functional connections per array decreased, but the reliability of those connections increased. The networks maintained a balance in spiking and bursting dynamics in response to stimulation and sharpened network routing. These plastic characteristics of the network revealed the dynamic architecture of hippocampal computations in response to stimulation by selective routing on a spatiotemporal scale in single axons.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"181 2 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138553545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential. GABA能信号在酒精使用障碍和戒断中的作用：病理学意义和治疗潜力。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-20 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1218737

Ravinder Naik Dharavath, Celeste Pina-Leblanc, Victor M Tang, Matthew E Sloan, Yuliya S Nikolova, Peter Pangarov, Anthony C Ruocco, Kevin Shield, Daphne Voineskos, Daniel M Blumberger, Isabelle Boileau, Nikki Bozinoff, Philip Gerretsen, Erica Vieira, Osnat C Melamed, Etienne Sibille, Lena C Quilty, Thomas D Prevot

{"title":"GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential.","authors":"Ravinder Naik Dharavath, Celeste Pina-Leblanc, Victor M Tang, Matthew E Sloan, Yuliya S Nikolova, Peter Pangarov, Anthony C Ruocco, Kevin Shield, Daphne Voineskos, Daniel M Blumberger, Isabelle Boileau, Nikki Bozinoff, Philip Gerretsen, Erica Vieira, Osnat C Melamed, Etienne Sibille, Lena C Quilty, Thomas D Prevot","doi":"10.3389/fncir.2023.1218737","DOIUrl":"10.3389/fncir.2023.1218737","url":null,"abstract":"Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"17 ","pages":"1218737"},"PeriodicalIF":3.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autogenous cerebral processes: an invitation to look at the brain from inside out. 自主大脑过程：一种从内到外观察大脑的邀请。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-10-19 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1253609

Pedro E Maldonado, Miguel Concha-Miranda, Miriam Schwalm

引用次数: 0

Potential for host-symbiont communication via neurotransmitters and neuromodulators in an aneural animal, the marine sponge Amphimedon queenslandica. 通过神经递质和神经调节剂与宿主共生体交流的潜力在非整倍体动物，海洋海绵昆士兰两栖动物中。

IF 3.5 3区医学

Frontiers in Neural Circuits Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1250694

Xueyan Xiang, Arturo A Vilar Gomez, Simone P Blomberg, Huifang Yuan, Bernard M Degnan, Sandie M Degnan

{"title":"Potential for host-symbiont communication via neurotransmitters and neuromodulators in an aneural animal, the marine sponge Amphimedon queenslandica.","authors":"Xueyan Xiang, Arturo A Vilar Gomez, Simone P Blomberg, Huifang Yuan, Bernard M Degnan, Sandie M Degnan","doi":"10.3389/fncir.2023.1250694","DOIUrl":"10.3389/fncir.2023.1250694","url":null,"abstract":"Interkingdom signalling within a holobiont allows host and symbionts to communicate and to regulate each other's physiological and developmental states. Here we show that a suite of signalling molecules that function as neurotransmitters and neuromodulators in most animals with nervous systems, specifically dopamine and trace amines, are produced exclusively by the bacterial symbionts of the demosponge Amphimedon queenslandica. Although sponges do not possess a nervous system, A. queenslandica expresses rhodopsin class G-protein-coupled receptors that are structurally similar to dopamine and trace amine receptors. When sponge larvae, which express these receptors, are exposed to agonists and antagonists of bilaterian dopamine and trace amine receptors, we observe marked changes in larval phototactic swimming behaviour, consistent with the sponge being competent to recognise and respond to symbiont-derived trace amine signals. These results indicate that monoamines synthesised by bacterial symbionts may be able to influence the physiology of the host sponge.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"17 ","pages":"1250694"},"PeriodicalIF":3.5,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration. 棘皮放射状胶质细胞在成体细胞更新、不确定生长和再生中的作用。

IF 3.4 3区医学

Frontiers in Neural Circuits Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI: 10.3389/fncir.2023.1258370

Vladimir Mashanov, Soji Ademiluyi, Denis Jacob Machado, Robert Reid, Daniel Janies

{"title":"Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration.","authors":"Vladimir Mashanov, Soji Ademiluyi, Denis Jacob Machado, Robert Reid, Daniel Janies","doi":"10.3389/fncir.2023.1258370","DOIUrl":"10.3389/fncir.2023.1258370","url":null,"abstract":"Echinoderms are a phylum of marine deterostomes with a range of interesting biological features. One remarkable ability is their impressive capacity to regenerate most of their adult tissues, including the central nervous system (CNS). The research community has accumulated data that demonstrates that, in spite of the pentaradial adult body plan, echinoderms share deep similarities with their bilateral sister taxa such as hemichordates and chordates. Some of the new data reveal the complexity of the nervous system in echinoderms. In terms of the cellular architecture, one of the traits that is shared between the CNS of echinoderms and chordates is the presence of radial glia. In chordates, these cells act as the main progenitor population in CNS development. In mammals, radial glia are spent in embryogenesis and are no longer present in adults, being replaced with other neural cell types. In non-mammalian chordates, they are still detected in the mature CNS along with other types of glia. In echinoderms, radial glia also persist into the adulthood, but unlike in chordates, it is the only known glial cell type that is present in the fully developed CNS. The echinoderm radial glia is a multifunctional cell type. Radial glia forms the supporting scaffold of the neuroepithelium, exhibits secretory activity, clears up dying or damaged cells by phagocytosis, and, most importantly, acts as a major progenitor cell population. The latter function is critical for the outstanding developmental plasticity of the adult echinoderm CNS, including physiological cell turnover, indeterminate growth, and a remarkable capacity to regenerate major parts following autotomy or traumatic injury. In this review we summarize the current knowledge on the organization and function of the echinoderm radial glia, with a focus on the role of this cell type in adult neurogenesis.","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"17 ","pages":"1258370"},"PeriodicalIF":3.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0