塑造嗅觉图谱：细胞类型特异性活动模式引导电路形成

IF 3.4 3区医学 Q2 NEUROSCIENCES

Frontiers in Neural Circuits Pub Date : 2024-05-27 DOI:10.3389/fncir.2024.1409680

Ai Nakashima, Haruki Takeuchi

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引用次数: 0

摘要

大脑会构建有空间组织的感官图谱来表示感官信息。感官图谱的形成历来被认为取决于神经元的同步活动。然而，最近来自嗅觉系统的证据表明，细胞类型特异的自发活动时间模式在形成嗅觉肾小球图谱的过程中起着指导作用。这些发现挑战了传统观点，凸显了研究神经活动时空动态以了解复杂神经回路发展的重要性。这篇综述讨论了嗅觉系统新发现的意义，并概述了未来的研究方向。

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Shaping the olfactory map: cell type-specific activity patterns guide circuit formation

The brain constructs spatially organized sensory maps to represent sensory information. The formation of sensory maps has traditionally been thought to depend on synchronous neuronal activity. However, recent evidence from the olfactory system suggests that cell type-specific temporal patterns of spontaneous activity play an instructive role in shaping the olfactory glomerular map. These findings challenge traditional views and highlight the importance of investigating the spatiotemporal dynamics of neural activity to understand the development of complex neural circuits. This review discusses the implications of new findings in the olfactory system and outlines future research directions.

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来源期刊

Frontiers in Neural Circuits NEUROSCIENCES-

CiteScore

6.00

自引率

5.70%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.