Frontiers in Medicine最新文献

{"title":"Exploration of key genes associated with oxidative stress in polycystic ovary syndrome and experimental validation.","authors":"Qinhua Li, Lei Liu, Yuhan Liu, Tingting Zheng, Ningjing Chen, Peiyao Du, Hong Ye","doi":"10.3389/fmed.2025.1493771","DOIUrl":"https://doi.org/10.3389/fmed.2025.1493771","url":null,"abstract":"<p><strong>Introduction: </strong>The current study demonstrated that oxidative stress (OS) is closely related to the pathogenesis of polycystic ovary syndrome (PCOS). However, there are numerous factors that lead to OS, therefore, identifying the key genes associated with PCOS that contribute to OS is crucial for elucidating the pathogenesis of PCOS and selecting appropriate treatment strategies.</p><p><strong>Methods: </strong>Four datasets (GSE95728, GSE106724, GSE138572, and GSE145296) were downloaded from the gene expression omnibus (GEO) database. GSE95728 and GSE106724 were combined to identify differentially expressed genes (DEGs) in PCOS. weighted gene correlation network analysis (WGCNA) was used to screen key module genes associated with PCOS. Differentially expressed OS related genes (DE-OSRGs) associated with PCOS were obtained by overlapping DEGs, key module genes, and OSRGs. Subsequently, the optimal machine model was obtained to identify key genes by comparing the performance of the random forest model (RF), support vector machine model (SVM), and generalized linear model (GLM). The molecular networks were constructed to reveal the non-coding regulatory mechanisms of key genes based on GSE138572 and GSE145296. The Drug-Gene Interaction Database (DGIdb) was used to predict the potential therapeutic agents of key genes for PCOS. Finally, the expression of key OSRGs was validated by RT-PCR.</p><p><strong>Results: </strong>In this study, 8 DE-OSRGs were identified. Based on the residuals and root mean square error of the three models, the best performance of RF was derived and 7 key genes (<i>TNFSF10, CBL, IFNG, CP, CASP8, APOA1</i>, and <i>DDIT3</i>) were identified. The GSEA enrichment analysis revealed that <i>TNFSF10, CP, DDIT3</i>, and <i>INFG</i> are all enriched in the NOD-like receptor signaling pathway and natural killer cell-mediated cytotoxicity pathways. The molecular regulatory network uncovered that both <i>TNFSF10</i> and <i>CBL</i> are regulated by non-coding RNAs. Additionally, 70 potential therapeutic drugs for PCOS were predicted, with ibuprofen associated with <i>DDIT3</i> and <i>IFNG</i>. RT-qPCR validation confirmed the expression trends of key genes <i>IFNG</i>, <i>DDIT3</i>, and <i>APOA1</i> were consistent with the dataset, and the observed differences were statistically significant (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The identification of seven key genes and molecular regulatory networks through bioinformatics analysis is of great significance for exploring the pathogenesis and therapeutic strategies of PCOS.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1493771"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social participation patterns and associations with subsequent cognitive function in older adults with cognitive impairment: a latent class analysis.","authors":"Xin Li, Haishan Feng, Qingling Chen","doi":"10.3389/fmed.2025.1493359","DOIUrl":"https://doi.org/10.3389/fmed.2025.1493359","url":null,"abstract":"<p><strong>Background: </strong>Social participation (SP) has been associated with cognitive benefits among older adults; however, little is known about SP patterns and their relationships with cognitive function in cognitively impaired populations. This study aimed to identify SP patterns among cognitively impaired older individuals and evaluate their associations with subsequent cognitive function, specifically mental intactness and episodic memory.</p><p><strong>Methods: </strong>Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS), including 5,673 individuals aged 60 years and older with cognitive impairment from 2015 to 2018. Latent class analysis (LCA) was used to identify SP patterns, and hierarchical linear regression analyses were conducted to examine associations between these patterns and cognitive function.</p><p><strong>Results: </strong>Four distinct SP patterns were identified: \"Offline Social Participation Group\" (Class 1), \"Intellectual Social Participation Only Group\" (Class 2), \"Club and Volunteer Activities Group\" (Class 3), and \"Minimal Social Participation Group\" (Class 4). The Class 4 comprised the majority (73%) and exhibited the poorest cognitive outcomes. Compared to the Class 4, Class 2 showed significant improvements in mental intactness (<i>p</i> < 0.001) and episodic memory (<i>p</i> = 0.022), while Class 3 demonstrated significant improvements in mental intactness (<i>p</i> = 0.032) but not episodic memory. Class 1 showed significant improvements in episodic memory (<i>p</i> = 0.023).</p><p><strong>Conclusion: </strong>This study highlights the cognitive benefits of social participation, particularly intellectual activities, for older adults with cognitive impairment. Targeted interventions promoting SP, especially intellectual activities, are essential to mitigate cognitive decline and improve cognitive resilience in vulnerable populations.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1493359"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Precision medicine: biomarker testing for diagnosis and treatment of cardiovascular disease.","authors":"Hendrianus Hendrianus, Eliano Navasere, Diana Gorog, Paul A Gurbel, Sang-Wook Kim, Young-Hoon Jeong","doi":"10.3389/fmed.2025.1564155","DOIUrl":"https://doi.org/10.3389/fmed.2025.1564155","url":null,"abstract":"","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1564155"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and contributing factors of depression among women with infertility in low-resource settings: a systematic review and meta-analysis.","authors":"Shimelis Tadesse, Henok Kumsa, Gemeda Wakgari Kitil, Alex Ayenew Chereka, Getnet Gedefaw, Fiker Chane, Esuyawkal Mislu","doi":"10.3389/fmed.2025.1477483","DOIUrl":"https://doi.org/10.3389/fmed.2025.1477483","url":null,"abstract":"<p><strong>Background: </strong>Depressive symptoms are the most common manifestations of psychiatric disorders among women with infertility. In low-resource settings, the overall prevalence and contributing factors of depressive symptoms among women with infertility remain unknown.</p><p><strong>Objectives: </strong>To estimate the prevalence and contributing factors of depression among women with infertility in low-resource settings.</p><p><strong>Methods: </strong>A review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The PubMed, MEDLINE, Google Scholar, and Cochrane databases were used to identify eligible studies published up to 30 November 2024. Three authors independently extracted the data. Studies that reported depression among women with infertility were included in this review. The data were analyzed with STATA version 14, and a meta-analysis was conducted using a random-effects model. Publication bias and heterogeneity were assessed via Eager's tests and I². Subgroup and sensitivity analyses were performed to identify the potential source/s of heterogeneity. A <i>p</i>-value of 0.05 was declared as statistically significant. The findings were synthesized and presented using texts, tables, and forest plots with measures of effect and 95% confidence interval (CI).</p><p><strong>Results: </strong>Seventeen published cross-sectional studies that met the inclusion criteria with a total of 3,528 women with infertility were selected for this study. The pooled prevalence of depression among women with infertility was 48.77% (95% CI (35.86, 61.67). Good functioning family {OR 0.71 [95% CI (0.51, 0.97), I²: 0.00%]}, good husband support {OR 0.52 [95% CI (0.34, 0.79), I²: 0.00%]}, primary infertility {OR 2.55 [95% CI (1.36, 4.79), I²: 68.53%]}, history of divorce {OR 4.41 [95% CI (2.11, 9.24), I²: 0.00%]}, and duration of infertility lasting more than 10 years {OR 6.27 [95% CI (2.74, 14.34), I²: 15.26%]} were statistically significant.</p><p><strong>Conclusion: </strong>Depression was high among women with infertility in low-resource settings such as Africa compared to those in high-income countries, men, and pregnant mothers. Good functioning family, good husband support, primary infertility, history of divorce, and duration of infertility lasting more than 10 years were statistically associated. Therefore, African countries and the stakeholders in collaboration with mental health experts and gynecological care providers should address these problems in order to reduce or prevent depression among women with infertility.</p><p><strong>Systematic review registration: </strong>PROSPERO (ID: CRD42024516458).</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1477483"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of physician engagement in medical research.","authors":"Oscar Gonzalez-Perez, Cesar Ramos-Remus","doi":"10.3389/fmed.2025.1537023","DOIUrl":"https://doi.org/10.3389/fmed.2025.1537023","url":null,"abstract":"","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1537023"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Update on glaucoma research: from basic science to clinical practice.","authors":"Alessio Martucci, Maria Dolores Pinazo-Duran, Carlo Nucci","doi":"10.3389/fmed.2025.1572755","DOIUrl":"https://doi.org/10.3389/fmed.2025.1572755","url":null,"abstract":"","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1572755"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Same duodenal neuroendocrine tumors, different endoscopic resection methods: a case report and literature review.","authors":"Jinguo Liu, Liangliang Yu","doi":"10.3389/fmed.2025.1577088","DOIUrl":"https://doi.org/10.3389/fmed.2025.1577088","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmed.2024.1401241.].</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1577088"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The activation, clinical course, and clinical outcome of using an unconventional electrode configuration in a patient newly implanted with Inspire® therapy: a case report.","authors":"Ruchir P Patel, Chelsie E Rohrscheib","doi":"10.3389/fmed.2025.1501242","DOIUrl":"https://doi.org/10.3389/fmed.2025.1501242","url":null,"abstract":"<p><p>Hypoglossal nerve stimulation therapy via the Inspire® implant is a common alternative to positive airway pressure (PAP) treatment for obstructive sleep apnea (OSA). While hypoglossal nerve stimulation (HGNS) therapy offers a high rate of successful treatment outcomes, the post-activation care pathway, which involves gradual titration of the amplitude to achieve both subjective and objective improvements, can be lengthy, ranging from 3 to 12 months post-activation. Here, we report a case of a 55-year-old man with severe obstructive sleep apnea and a history of hypertension who underwent successful activation and titration of the Inspire® implant to achieve subjective and objective relief within 8 weeks post-implantation and 5 weeks post-activation, using an unconventional starting electrode configuration. This case highlights the need for further exploration of alternative Inspire® activation and management protocols that may lead to improved patient outcomes and higher success rates.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1501242"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pedagogical strategies for supporting learning and student well-being in environmentally sustainable healthcare.","authors":"Nara Jones, Graeme Horton, Michelle Guppy, Georgia Brown, John Boulton","doi":"10.3389/fmed.2025.1446569","DOIUrl":"https://doi.org/10.3389/fmed.2025.1446569","url":null,"abstract":"<p><p>Planetary health education needs fresh approaches to engage learners and educators in positive visions and future planning to navigate the societal challenges of climate change. The human health impacts of the climate crisis, environmental degradation and pollution are far-reaching and compounding in nature. International leaders in healthcare are recognizing the time-pressured opportunity to mobilize and motivate colleagues to optimize health outcomes by addressing these issues. Healthcare systems across the globe contribute significantly to ecological footprints through greenhouse gas emissions and consumption of various polluting materials. Therefore, the necessity to prepare future health professionals to identify and manage environmental health conditions in their patients, as well as foster their future role as leaders and advocates in sustainable healthcare is acute. Health education organizations have begun to appreciate this need and have developed learning objectives to guide curricula. In the development and implementation of content on environmentally sustainable healthcare, an important consideration is the affective and moral distress from the confronting and often overwhelming nature of the topic. The main objective in teaching planetary health is to equip learners with the tools and skills to address the relevant health issues in their professional role whilst providing the support necessary for them to accept these harsh realities. The University of Newcastle and University of New England Joint Medical Program's, four-week course in Sustainable Healthcare aims to meet this objective. In this article we discuss how our curriculum utilizes Self-Determination Theory (SDT) and other psychological strategies to support learners' well-being and motivation. SDT explains the need for supporting autonomy, relatedness and competence in the learning environment. Strategies employed to address these include providing students with the opportunity to select discussion topics that they contribute to, maximizing choice of focus for the assessment task, utilizing personal reflections, case-based learning scenarios and incorporating presentations from relatable industry leaders.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1446569"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of chronic diseases and lifestyle on sarcopenia risk in older adults: a population-based longitudinal study.","authors":"Wu-Xiao Wei, Zhen-Fang Mao, Meng-Li Chen, Lian Meng","doi":"10.3389/fmed.2025.1500915","DOIUrl":"10.3389/fmed.2025.1500915","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia, characterized by the gradual decline of muscle mass and strength, seriously affects the health and mobility of older adults. The purpose of this study is to investigate the risk factors for sarcopenia, particularly the relationship between chronic diseases and lifestyle factors in individuals aged 60 and over.</p><p><strong>Methods: </strong>This study used data from the Longitudinal Study on Health and Retirement in China (CHARLS) collected in 2011 and 2015. All eligible participants were classified according to the standards established by the Asian Sarcopenia Working Group in 2019. The evaluation of sarcopenia was based on a comprehensive score across five dimensions: strength, assistance in walking, rise from a chair, climb stairs, and falls. A multivariate logistic regression model was employed to explore the risk factors for sarcopenia.</p><p><strong>Results: </strong>The risk of sarcopenia is significantly influenced by multiple factors. Key findings include the association between past drinking and an increased risk of sarcopenia (HR = 2.198, 95% CI: 1.072-4.560, <i>p</i> < 0.05), indicating that individuals with a history of drinking have more than twice the risk of sarcopenia compared to non-drinkers. Chronic diseases such as stroke were also associated with a significantly elevated risk (HR = 3.137, 95% CI: 1.128-8.721, <i>p</i> < 0.05). Conversely, participation in social activities significantly reduced the risk of sarcopenia (HR = 0.482, 95% CI: 0.265-0.876, <i>p</i> < 0.05). A three-piece spline regression model revealed a nonlinear relationship between physical activity and the risk of sarcopenia, characterized by an initial decline in risk followed by an increase as physical activity levels rose. Moderate-intensity physical activity reduced the risk of sarcopenia by approximately 35% (HR ≈ 0.65). However, high-intensity physical activity led to a rebound in risk, increasing the likelihood of sarcopenia relative to moderate activity. Similarly, adequate sleep duration was associated with a reduced risk of sarcopenia, whereas excessive sleep counteracted this benefit.</p><p><strong>Conclusion: </strong>The findings underscore the critical role of lifestyle modifications and balanced physical activity in mitigating the risk of sarcopenia among older adults. Implementing targeted interventions for high-risk groups is essential to reduce the incidence of sarcopenia.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1500915"},"PeriodicalIF":3.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}