Frontiers in Medicine最新文献

{"title":"Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot study.","authors":"Sumaiah J Alarfaj, Sahar M El-Haggar, Sahar K Hegazy, Maha M Maher, Monir M Bahgat, Thanaa A Elmasry, Sarah Alrubia, Amsha S Alsegiani, Mostafa M Bahaa","doi":"10.3389/fmed.2024.1490178","DOIUrl":"10.3389/fmed.2024.1490178","url":null,"abstract":"<p><strong>Background: </strong>Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon. Several preclinical studies investigated the beneficial effects of atorvastatin in colitis. Activation of sphingosine 1 phosphate (S1P)/ tumor necrosis factor-alpha (TNF-<i>α</i>)/ interleukin-6 (IL-6) pathways has been confirmed in the pathogenesis of UC and preclinical studies proved the efficacy of atorvastatin on these pathways.</p><p><strong>Aim: </strong>To investigate the role of atorvastatin on S1P/TNF-<i>α</i>/IL-6 pathway in UC.</p><p><strong>Methods: </strong>Patients with mild to moderate UC were allocated into two groups in this pilot study. For 6 months, Group 1 (placebo group) received both a placebo and 1 g of mesalamine three times daily (t.i.d.). Group 2, (the atorvastatin group) received atorvastatin 80 mg once daily and 1 g of mesalamine t.i.d. A gastroenterologist evaluated the patients' colitis severity by partial Mayo score index (PMS). Serum IL-6, S1P, TNF-<i>α</i>, nitric oxide (NO), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fecal calprotectin were measured before and after treatment. Short Form 36 questionnaire (SF-36) was also assessed. A clinical response was defined as a decline in the rectal bleeding sub score of at least one point, and a decrease in PMS of at least two points. Clinical remission was defined as a PMS of less than 2 and the absence of any single sub score greater than 1.</p><p><strong>Primary outcome: </strong>Decreased PMS and improved quality of life.</p><p><strong>Secondary outcome: </strong>Change in the level of measured biomarkers.</p><p><strong>Results: </strong>Compared to the placebo group (<i>n</i> = 24), the atorvastatin group (<i>n</i> = 23) exhibited a significant decrease in the level of IL-6 (<i>p</i> = 0.001), S1P (<i>p</i> = 0.0001), TNF-<i>α</i> (<i>p</i> = 0.003), NO (<i>p</i> = 0.0001), CRP (<i>p</i> = 0.015), ESR (<i>p</i> = 0.012), PMS (<i>p</i> = 0.013), and fecal calprotectin (<i>p</i> = 0.0003), and improved SF-36 (<i>p</i> = 0.006). In placebo group, the response rate was 83.33% (<i>n</i> = 20/24) for PMS, and the remission rate was 45.83% (<i>n</i> = 11/24). In the atorvastatin group, the response rate was 91.3% (<i>n</i> = 21/23), and the remission rate was 60.8% (<i>n</i> = 14/23) for PMS.</p><p><strong>Conclusion: </strong>Atorvastatin could be an adjunctive therapy for patients with UC.</p><p><strong>Clinical trial registration: </strong>https://www.clinicaltrials.gov/, Identifier NCT05561062.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1490178"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study.","authors":"Liyan Dong, Yuhang Yin, Huiyuan Lu, Di Sun, Dongyang Wang, Deli Zou, Xingshun Qi","doi":"10.3389/fmed.2024.1432137","DOIUrl":"10.3389/fmed.2024.1432137","url":null,"abstract":"<p><strong>Background: </strong>Primary liver cancer (PLC) is one of the most common cancers worldwide. ABO blood groups and rhesus (Rh) factor are inherited characteristics. Their association with the presence of PLC remains unclear in cirrhotic patients. Hence, the purpose of this cross-sectional study was to evaluate whether blood groups were risk factors for the presence of PLC in cirrhosis.</p><p><strong>Methods: </strong>Patients with liver cirrhosis who were consecutively admitted to the Department of Gastroenterology of the General Hospital of Northern Theater Command from 1 January 2010 to 30 June 2014 were retrospectively screened. Logistic regression analyses were performed to explore the association of ABO blood groups and Rh factor with PLC in cirrhotic patients. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated after adjusting for gender, age, family history of liver cirrhosis, HBV-DNA positivity, and etiology of cirrhosis. Subgroup analyses were performed according to the etiology of liver cirrhosis.</p><p><strong>Results: </strong>Overall, 1,158 cirrhotic patients without PLC and 240 cirrhotic patients with PLC were included in the study. After adjusting for confounding factors, non-O (aOR = 0.763; 95%CI = 0.449-1.298, <i>p</i> = 0.319), A (aOR = 0.643; 95%CI = 0.332-1.246, <i>p</i> = 0.191), B (aOR = 0.835; 95%CI = 0.453-1.540, <i>p</i> = 0.564), AB (aOR = 0.888; 95%CI = 0.363-2.170, <i>p</i> = 0.795), and Rh (+) (aOR = 0.239; 95%CI = 0.036-1.571, <i>p</i> = 0.136) blood groups were not independently associated with PLC in cirrhotic patients. In the subgroup analysis of HBV-related cirrhotic patients, the proportion of A blood group was significantly lower in cirrhotic patients with PLC than in those without PLC (24.17% vs. 33.99%, <i>p</i> < 0.001); however, in HCV- and alcohol-related cirrhotic patients, the proportions of ABO blood groups and Rh factor were not significantly different between the two groups.</p><p><strong>Conclusion: </strong>ABO blood groups and Rh factor may not be associated with the presence of PLC in cirrhotic patients.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1432137"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decade of progress and innovation in dermatology.","authors":"Robert Gniadecki","doi":"10.3389/fmed.2024.1546471","DOIUrl":"10.3389/fmed.2024.1546471","url":null,"abstract":"","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1546471"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of transcutaneous electrical acupoint stimulation on length of stay for patients after undergoing surgery for colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.","authors":"YaDan Xiao, Fei Yang, JunLiang Zhou, YuanLing Huang, YaXin Xiao","doi":"10.3389/fmed.2025.1503714","DOIUrl":"10.3389/fmed.2025.1503714","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the effect of transcutaneous electrical acupoint stimulation (TEAS) on the length of stay (LOS) of patients undergoing surgery for colorectal cancer.</p><p><strong>Methods: </strong>A systematic review was conducted by searching databases, including PubMed, Embase, Cochrane Library, China Network Knowledge Infrastructure, and Wanfang Database for randomized controlled trials (RCTs) published up to August 24, 2024. Statistical analyses were performed using the Cochrane Collaboration Review Manager (RevMan 5.4). The quality of the RCTs was assessed using the Cochrane Systematic Review Handbook 5.1 and its recommended risk-of-bias assessment tool. Two independent investigators screened and extracted the data and performed statistical analysis.</p><p><strong>Results: </strong>Seven RCTs were included in the analysis. The findings indicated that TEAS significantly reduced the LOS of patients undergoing surgery for colorectal cancer (mean difference = -1.36, 95% confidence interval = -1.95 to -0.78, <i>p</i> < 0.00001). Subgroup analyses of outcome measures, intervention methods, and intervention time points demonstrate the significant effect of TEAS on reducing LOS.</p><p><strong>Conclusion: </strong>TEAS effectively shortens the LOS of patients undergoing surgery for colorectal cancer. Future studies should focus on refining TEAS protocols and exploring their effects on other aspects of postoperative recovery to fully establish their roles in perioperative management.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1503714"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse clinical manifestations and prognosis in a couple's mercury poisoning caused by skin-lightening creams: two case reports and literature review.","authors":"Huixia Ji, Ye Chen, Dandan Liu, Tongzhou Zhou, Yuhua Tang","doi":"10.3389/fmed.2024.1511493","DOIUrl":"10.3389/fmed.2024.1511493","url":null,"abstract":"<p><p>Skin exposure to mercury-containing creams occurs most commonly in young and middle-aged women and, in a few cases, in men. This article presents the symptoms and prognosis of a couple who developed mercury poisoning after cosmetic use of similar duration and dosage. Case 1 is a 33-year-old man who developed nephrotic syndrome after using skin-lightening creams containing mercury over 9 months. Renal puncture pathology indicated membranous nephropathy. During the course of the illness, the patient intermittently took Chinese medicine. Approximately 4 months later, the patient developed pulmonary thrombosis and lower extremity venous thrombosis as a result of fatigue driving and had to undergo thrombolysis and filter implantation. A urine mercury level of 65.4 μg/g·creatinine was detected in the patient. The urine protein level remained positive 8 months after mercury removal. Case 2 is a 30-year-old woman, the wife of case 1, who used the same creams for 9 months with her husband and had a urine mercury level of 80 μg/g·creatinine. The patient experienced sleep disturbances, fatigue, and irritability. In Case 2, neurasthenia symptoms were relieved following mercury removal, and no other complications were observed. There have been very few reports regarding male patients developing nephrotic syndrome as a consequence of using cosmetics that contain mercury. However, clinicians should not neglect this cause when dealing with newly diagnosed male patients with nephrotic syndrome. The treatment and prognosis of male patients are less well established, and changes in their condition must be closely monitored.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1511493"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation.","authors":"Chuanren Zhuang, Ruomeng Hu, Ke Li, Zhengshuang Liu, Songjie Bai, Sheng Zhang, Xuehuan Wen","doi":"10.3389/fmed.2024.1483710","DOIUrl":"10.3389/fmed.2024.1483710","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-associated acute kidney injury (S-AKI) has a significant impact on patient survival, with continuous renal replacement therapy (CRRT) being a crucial intervention. However, the optimal timing for CRRT initiation remains controversial.</p><p><strong>Methods: </strong>Using the MIMIC-IV database for model development and the eICU database for external validation, we analyzed patients with S-AKI to compare survival rates between early and late CRRT initiation groups. Propensity score matching was performed to address potential selection bias. Subgroup analyses stratified patients by disease severity using SOFA scores (low ≤10, medium 11-15, high >15) and creatinine levels (low ≤3 mg/dL, medium 3-5 mg/dL, high >5 mg/dL). Multiple machine learning models were developed and evaluated to predict patient prognosis, with Shapley Additive exPlanations (SHAP) analysis identifying key prognostic factors.</p><p><strong>Results: </strong>After propensity score matching, late CRRT initiation was associated with improved survival probability, but led to increased hospital and ICU stays. Subgroup analyses showed consistent trends favoring late CRRT across all SOFA categories, with the most pronounced effect in high SOFA scores (>15, <i>p</i> = 0.058). The GBM model demonstrated robust predictive performance (average C-index 0.694 in validation and test sets). SHAP analysis identified maximum lactate levels, age, and minimum SpO2 as the strongest predictors of mortality, while CRRT timing showed relatively lower impact on outcome prediction.</p><p><strong>Conclusion: </strong>While later initiation of CRRT in S-AKI patients was associated with improved survival, this benefit comes with increased healthcare resource utilization. The clinical parameters, rather than CRRT timing, are the primary determinants of patient outcomes, suggesting the need for a more personalized approach to CRRT initiation based on overall illness severity.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1483710"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of a hydrophobic trifocal diffractive intraocular lens: a literature review.","authors":"Deborah Ristvedt, Camille Bosc, Vance Thompson","doi":"10.3389/fmed.2025.1533161","DOIUrl":"10.3389/fmed.2025.1533161","url":null,"abstract":"<p><p>The aim of this review is to summarize the clinical outcomes reported in patients following the implantation of the hydrophobic diffractive trifocal FineVision HP intraocular lens (IOL). A literature search in PubMed (U.S. National Library of Medicine) was performed to identify publications, both prospective and retrospective, which have reported the clinical outcomes of patients who were implanted with this IOL model after cataract or refractive lens exchange surgeries. A total of 18 clinical studies published between 2019 and 2024 were included in this review. The available data reported in the different clinical publications was analyzed in detail, focusing mainly on refraction, visual acuity, the defocus curve, optical quality, contrast sensitivity, and patient-reported outcome questionnaires. In addition, the adverse events and other measurements reported in some studies were also analyzed. Our review encompassed a total of 1,028 eyes analyzed at different follow-up periods up to a maximum of 24 months. The analysis carried out in this review leads us to conclude that the FineVision HP IOL provides good refractive outcomes and excellent visual performance when implanted.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1533161"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Clonorchis sinensis</i> and <i>Echinostoma hortense</i> detected by endoscopy and molecular characterization: two case reports and update on diagnosis.","authors":"Lijia Wen, Benhe Wang, Hui Zhang","doi":"10.3389/fmed.2024.1515539","DOIUrl":"10.3389/fmed.2024.1515539","url":null,"abstract":"<p><p><i>Clonorchis sinensis</i> (<i>C. sinensis</i>) and <i>Echinostoma hortense</i> (<i>E. Hortense</i>) infections represent significant food-borne zoonotic parasitic diseases. <i>C. sinensis</i> stands as the primary parasite underlying cholangitis, cholelithiasis, and even cholangiocarcinoma, whereas <i>E. Hortense</i> parasitizes the duodenum. Unfortunately, the non-specific clinical presentations of these two trematodes frequently mislead clinicians, resulting in overlooks or misdiagnoses, and consequently, inadequate treatment. We diagnosed digestive system trematodes through endoscopic observation and molecular methods. Herein, we present a case where <i>C. sinensis</i> was definitively diagnosed through direct observation under duodenoscopy. For the first time, we captured the entire migratory process of the parasite from the common bile duct into the intestinal lumen. In another case, multiple active trematodes were detected on the duodenal wall under duodenoscopy, subsequently extracted using endoscopic forceps. Based on the morphology of the worms and their eggs, an initial diagnosis of <i>Echinostoma</i> was made. To confirm the species, we designed primers targeting the ribosomal ITS (internal transcribed spacer) and mitochondrial COX-1 (cyclooxygenase-1) genes, followed by PCR amplification and sequencing. The results conclusively matched the sequence of <i>E. Hortense</i>, verifying our final diagnosis. Our proposed approach, integrating endoscopy with molecular characteristics, offers novel strategies for diagnosing trematode infections. This methodology represents a significant advancement in the field, enhancing the accuracy and timeliness of treatment interventions.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1515539"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of clary sage (<i>Salvia sclarea</i> L.) oil and linalyl acetate on depression levels in diabetic foot ulcer patients with T2DM: a randomized blinded controlled trial.","authors":"Ji Won Son, Purum Kang, Sun Seek Min, Geun Hee Seol","doi":"10.3389/fmed.2025.1523441","DOIUrl":"10.3389/fmed.2025.1523441","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcer (DFU) is a significant global health concern due to its substantial burden on individuals and healthcare systems. In addition to its physical impact, DFU has emotional effects on patients. This study analyzed the effects of inhaling clary sage (CS; <i>Salvia sclarea</i> L.) or linalyl acetate (LA) on depression and psychological factors in patients with DFU.</p><p><strong>Methods: </strong>This study, performed at the Diabetic Wound Center, enrolled DFU patients, categorized as having mild or moderate to severe depression based on visual analog scale (VAS) for depression scores. Patients were randomized to inhalation of 5% CS oil, 5% LA or almond oil (control) by natural breathing. Blood pressure, heart rate, Depression-VAS, Anxiety-VAS, and Stress-VAS were measured before and after inhalation.</p><p><strong>Results: </strong>This study enrolled 72 patients with DFU, including 43 with mild and 29 with moderate to severe depression. Of the 43 patients with mild depression, 14, 14, and 15 were randomized to inhalation of CS, LA, and almond oil, respectively. Of the 29 patients with moderate to severe depression, 9, 11, and 9 were randomized to inhalation of CS, LA, and almond oil, respectively. Compared with inhalation of almond oil, inhalation of CS oil significantly reduced stress (<i>p</i> < 0.05) and (<i>p</i> < 0.01) in patients with mild depression, whereas inhalation of LA significantly reduced anxiety-VAS (<i>p</i> < 0.05) and depression-VAS (<i>p</i> < 0.05) in patients with moderate to severe depression.</p><p><strong>Conclusion: </strong>Inhalation of CS oil may have the potential to alleviate stress and anxiety in DFU patients with mild depression, whereas inhalation of LA may have the potential to alleviate anxiety and depression in DFU patients with moderate to severe depression. These findings suggest that adjunct therapy in DFU patients should be individualized according to the degree of depression.</p><p><strong>Clinical trial registration: </strong>http://cris.nih.go.kr/, identifier KCT0009722.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1523441"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness rehabilitative therapy and Pridinol Mesylate in low back pain.","authors":"Lorenza Lauricella, Noemi Calabrese, Dalila Scaturro, Domenico Migliorino, Michele Vecchio, Giulia Letizia Mauro","doi":"10.3389/fmed.2024.1470996","DOIUrl":"10.3389/fmed.2024.1470996","url":null,"abstract":"<p><strong>Background: </strong>Spondylarthritis is a degenerative disease involving the intervertebral disc, vertebral bodies, and adjacent soft tissues. Treatment aims to slow disease progression and manage symptoms through an interdisciplinary approach. It can be conservative and rarely chirurgic.</p><p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of a rehabilitation combined with Pridinol Mesylate in the treatment of Spondylarthritis in elderly patients in terms of pain resolution, improving disability, and quality of life.</p><p><strong>Materials and methods: </strong>We conducted a retrospective study on patients with Spondylarthritis. The patients recruited (<i>n</i> = 86) were divided into three groups: the Combined Group (CG:28), who received a rehabilitation combined with Pridinol Mesylate (16 women and 12 men, age 66.4 ± 3.99); the Rehabilitation Group (RG, <i>n</i> = 26), who received only rehabilitation (14 women and 12 men, age 66.2 ± 3.84); and the Drug Group (DG: 32), who received only the administration of the Pridinol(18 women and 14 men, age of 66.3 ± 3.9).</p><p><strong>Results: </strong>The results show, at T1 (20 days after treatment) in the CG, statistically significant improvements for the NRS and QBPDS. In the RG, statistically significant improvements were observed only for the QBPDS scale. In the DG group, only pain improvement. At T2 (90 days after treatment), the CG showed improvements in NRS, QBPDS, and (SF-36). The RG and DG showed improvements for NRS and for QBPDS. By Bonferroni method, obtained statistically significant values for CG versus RG and for CG versus DG. No statistical significance was found between RG versus DG.</p><p><strong>Conclusion: </strong>Targeted rehabilitation treatment, combined with Pridinol Mesylate, reduced pain and improved disability in lumbar Spondylarthritis both in the short and medium term, with improved quality of life in elderly patients.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1470996"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}