Frontiers in Medicine最新文献

{"title":"Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.","authors":"Jing Wang, Meng Song, Jinming Tang, Haoran Yue, Xiaoyang Guo, Zhan Chen, Xiaolan Shen, Mingbo Cao","doi":"10.3389/fmed.2025.1513233","DOIUrl":"10.3389/fmed.2025.1513233","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is the third most prevalent cause of cancer-related mortality globally and the sixth most common cancer overall. It is critical to investigate new biomarkers and prognostic variables because there are currently no early diagnostic indicators. Actin-related proteins (ARPs) are involved in transcriptional regulation, chromatin remodeling, and DNA repair-all processes that have been connected to the development of cancer. However, it's still unclear how ARPs and HCC are related.</p><p><strong>Methods: </strong>Through the examination of databases like The Cancer Genome Atlas (TCGA) and The International Cancer Genome Consortium (ICGC), we examined the variations in the expression of ARPs between the transcriptomes of normal tissue and HCC. Furthermore, univariate and multivariate Cox analysis were used to assess the prognostic effects of ARPs. The investigation of immune cell infiltration and possible functional enrichment followed. Additionally, tissue chips containing regional liver cancer specimens were used to confirm ACTR6 expression and the clinical impact of prognosis using an immunohistochemistry (IHC) test. Finally, to investigate the expression and function of ACTR6 in liver cancer cells, real-time qPCR (RT-qPCR) assays, CCK-8, clone creation, cell cycle, and transwell migration and invasion experiments were carried out.</p><p><strong>Results: </strong>We found that, in addition to ACTR3C, 17 ARPs were significantly overexpressed in HCC compared with normal tissues. In both univariate and multivariate Cox models, ACTR6 and ACTL6A were identified as potential independent risk factors for the prognosis of HCC, with ACTR6 having the lowest <i>p</i>-value. Clinical samples also confirmed this conclusion. Furthermore, ACTR6 overexpression showed a strong connection with immune cell infiltration levels and clinical and pathological factors linked to a poor prognosis. Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.</p><p><strong>Conclusion: </strong>These findings demonstrate that ACTR6 is highly expressed in HCC and is associated with poor prognosis. In addition, ACTR6 may induce immune cell infiltration and promote hepatocarcinogenesis by regulating the cell cycle.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1513233"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MTFR2 promotes endometrial carcinoma cell proliferation and growth via the miR-132-3p/PI3K/Akt signaling pathway.","authors":"Zhijun Niu, Yue Zhang, Yishan Wang, Dongxia Liu, Junmin Wang, Tingting Shi, Xia Xu, Lei Li","doi":"10.3389/fmed.2024.1505071","DOIUrl":"10.3389/fmed.2024.1505071","url":null,"abstract":"<p><strong>Objective: </strong>Understanding the mechanisms underlying endometrial cancer progression is crucial for the development of effective targeted therapies. In this study, we investigated the role of MTFR2 in endometrial cancer cell.</p><p><strong>Methods: </strong>The expression of MTFR2 in endometrial cancer was analyzed using The Cancer Genome Atlas (TCGA) dataset and detected in endometrial cancer tissues and cells, respectively. Gain-of-function and loss-of-function approaches were utilized to investigate the impact of MTFR2 on endometrial cancer cell proliferation and tumorigenesis in both <i>in vitro</i> and <i>in vivo</i> settings. Computational tools were employed to predict microRNAs (miRNAs) that potentially regulate MTFR2, and these predictions were experimentally validated.</p><p><strong>Results: </strong>The expression of MTFR2 is enhanced in endometrial carcinoma, and it is positively correlated with the poor prognosis of patients. Functional studies show that MTFR2 promoted the proliferation, migration and invasion of endometrial cancer cells. Bioinformatics analysis and luciferase assays identified that MTFR2 is a potential target of miR-132-3p, and transfection with miR-132-3p mimics attenuated the MTFR2-induced activation of the PI3K/Akt pathway.</p><p><strong>Conclusion: </strong>Our findings highlight the critical role of MTFR2 in promoting endometrial cancer cell proliferation and growth through the miR-132-3p/PI3K/Akt signaling pathway. Targeting this signaling axis may offer potential therapeutic strategies for endometrial cancer treatment.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1505071"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Clinical management of freshwater stingray wounds using negative pressure therapy.","authors":"Janio J M Nattrodt, Victória A Bezerra-de-Freitas, Ana Paula S S Merval, Eloise T Filardi, Felipe A Cerni, Domingos S M Dantas, Alysson B M Lins, Luis E B Galan, Roberto C Carbonell, Manuela B Pucca","doi":"10.3389/fmed.2025.1536540","DOIUrl":"10.3389/fmed.2025.1536540","url":null,"abstract":"<p><p>Stingray injuries represent a significant occupational hazard, particularly for fishermen, and are commonly caused by freshwater stingrays of the Potamotrygonidae family. These stingrays are equipped with a sharp, bilaterally serrated spine that delivers venom, inducing vasoconstriction, severe pain, and ischemia. Such injuries are not only intensely painful but also debilitating, often rendering victims unable to work for weeks or even months. Traditional self-treatment practices, including the application of urine and herbal remedies, are widely relied upon in affected communities but are scientifically unproven and frequently lead to delayed or suboptimal care. This study presents two clinical cases of freshwater stingray envenomation from Roraima, the northernmost state of Brazil located within the Amazon Rainforest. Both cases were managed at the infectious disease unit of the General Hospital in Boa Vista, the state capital. Patients received evidence-based medical care, including intravenous antibiotic therapy and surgical debridement to remove necrotic and devitalized tissue. In one case, advanced negative pressure wound therapy (NPWT) was utilized during dressing changes, resulting in a clean wound devoid of edema and necrotic tissue, demonstrating the technique's effectiveness in promoting wound healing. By accelerating wound healing and mitigating complications such as infections and chronic wounds, NPWT significantly enhance patient outcomes. Furthermore, this study underscores the limitations of traditional remedies and advocates for the adoption of evidence-based interventions, particularly in regions like the Brazilian Amazon, where access to healthcare can be challenging.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1536540"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular regulators of alcoholic liver disease: a comprehensive analysis of microRNAs and long non-coding RNAs.","authors":"Lin Zhang, Rongqi Wang, Yuemin Nan, Lingbo Kong","doi":"10.3389/fmed.2025.1482089","DOIUrl":"10.3389/fmed.2025.1482089","url":null,"abstract":"<p><p>Many biomolecules and signaling pathways are involved in the development of alcoholic liver disease (ALD). The molecular mechanisms of ALD are not fully understood and there is no effective treatment. Numerous studies have demonstrated the critical role of non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), in ALD. miRNAs play an important regulatory role in the pathogenesis of ALD by controlling critical biological processes such as inflammation, oxidative stress, lipid metabolism, apoptosis and fibrosis. Among them, miR-155, miR-223 and miR-34a play a central role in these processes and influence the pathological process of ALD. In addition, lncRNAs are involved in regulating liver injury and repair by interacting with miRNAs to form a complex regulatory network. These findings help to elucidate the molecular mechanisms of ALD and provide a scientific basis for the development of new diagnostic markers and therapeutic targets. In this article, we review the roles and mechanisms of LncRNAs and miRNAs in ALD and their potential use as diagnostic markers and therapeutic targets.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1482089"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: HIF-1α alleviates high-glucose-induced renal tubular cell injury by promoting Parkin/PINK1-mediated mitophagy.","authors":"Lu Yu, Yulin Wang, Yan Hong Guo, Liuwei Wang, Zijun Yang, Zi Han Zhai, Lin Tang","doi":"10.3389/fmed.2025.1571785","DOIUrl":"https://doi.org/10.3389/fmed.2025.1571785","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmed.2021.803874.].</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1571785"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to viral load re-suppression and its predictors among adult patients on second-line anti-retro viral therapy in northeastern Ethiopia: multi-center prospective follow-up study.","authors":"Abebe Yehualaw Melaku, Niguss Cherie, Tarikua Afework Birhanu, Muluken Amare Wudu","doi":"10.3389/fmed.2025.1496144","DOIUrl":"10.3389/fmed.2025.1496144","url":null,"abstract":"<p><strong>Background: </strong>Despite the increasing number of patients on second-line antiretroviral therapy in low-income countries such as Ethiopia, there is limited evidence regarding the time to viral re-suppression. Therefore, this study aimed to assess the time to viral load re-suppression and its predictors among adult patients on second-line antiretroviral therapy in northeastern Ethiopia.</p><p><strong>Method: </strong>A multi-center, institution-based prospective follow-up study was conducted over 48 months, from February 2022 to February 2024, involving 526 adults living with human immunodeficiency virus (HIV) who were receiving second-line antiretroviral therapy in northeastern Ethiopia. Data were collected through face-to-face interviews and chart reviews. A Weibull proportional hazards model was fitted to identify the predictors of viral re-suppression.</p><p><strong>Results: </strong>The median time to viral re-suppression was 9 months (IQR = 3-15 months). The rate of viral re-suppression was 44.3 per 1,000 person-months (95% CI: 40.4-49). Predictors of viral re-suppression included disclosure of Human Immunodeficiency Virus (HIV) status [AHR 2.24 (95% CI: 1.4-3.7)], classification in World Health Organization (WHO) clinical stages I and II [AHR 6.9 (95% CI: 4.4-9.6)], receipt of tuberculosis (TB) preventive treatment [AHR 3.7 (95% CI: 2.3-5.93)], absence of first-line drug substitution history [AHR 1.44 (95% CI: 1.2-1.8)], and good adherence to treatment [AHR 1.9 (95% CI: 1.4-2.54)].</p><p><strong>Conclusion and recommendations: </strong>In this study, the time to viral load re-suppression was longer than expected. Disclosure status, WHO clinical stage I or II, receiving tuberculosis preventive treatment, and the absence of first-line drug substitution history were predictors of viral load re-suppression. Health managers and antiretroviral therapy care providers must improve the timing and effectiveness of early disclosure, encourage the early use of tuberculosis prophylaxis, and maintain good adherence through various strategies.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1496144"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the aggregate index of systemic inflammation and CKD: evidence from NHANES 1999-2018.","authors":"Dongli Huang, Hang Wu","doi":"10.3389/fmed.2025.1506575","DOIUrl":"10.3389/fmed.2025.1506575","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate the potential association between the aggregate index of systemic inflammation (AISI) and chronic kidney disease (CKD).</p><p><strong>Patients and methods: </strong>This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018. CKD was defined as either an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m² or the presence of albuminuria, defined as a urine albumin-to-creatinine ratio (ACR) of 30 mg/g or higher. Low eGFR is an eGFR of less than 60 mL/min/1.73 m². Multivariate regression analysis, smoothed curve fitting, and subgroup analyses were conducted to investigate the relationship between the Inflammatory status index (AISI) and CKD. The receiver operating characteristic (ROC) curve analysis was used to evaluate its ability to identify CKD and low eGFR. The AISI was transformed using the natural logarithm (Ln) for statistical analysis.</p><p><strong>Results: </strong>Of the 50,768 recruits, 49.86% were male. The prevalence of CKD and low eGFR was 20.31% and 8.57%, respectively. Ln-AISI was positively associated with CKD (OR = 1.24; 95% CI: 1.19, 1.28) and low eGFR (OR = 1.17; 95% CI:1.11, 1.24). Smooth curve fitting revealed a positive association between AISI and CKD and low eGFR. Subgroup analysis and interaction tests indicated that stratifications did not significantly alter the association between AISI and CKD and low eGFR. Threshold effect analysis indicated that this relationship became more pronounced when Ln-AISI exceeded 5.2 (AISI > 181.27). The ROC analysis showed that AISI had better discrimination and accuracy for identifying CKD and low eGFR compared to other inflammatory indicators [lymphocyte count (LYM), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), and the product of platelet count and neutrophil count (PPN)].</p><p><strong>Conclusion: </strong>AISI was significantly and positively correlated with the prevalence of CKD, and this relationship was more potent when AISI was greater than 181.27. Compared with other inflammatory indicators, AISI was more effective in identifying CKD.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1506575"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing the community training hub pilot as a model for multidisciplinary workforce development.","authors":"Sarah-Anne Munoz, Adalia Ikiroma, Rachel Erskine, Trish Gray","doi":"10.3389/fmed.2025.1518625","DOIUrl":"10.3389/fmed.2025.1518625","url":null,"abstract":"<p><p>The Community Training Hub (Hub) Pilot aims to contribute towards addressing recruitment and retention challenges in Scotland's primary care workforce, with a particular applicability to the Remote, Rural and Island (RRI) context. A mixed methods evaluation framework has been designed to assess the effectiveness of the Hub multidisciplinary training across healthcare teams. The pilot involves General Practitioners (GPs), Advanced Nurse Practitioners (ANPs), Pharmacists, and Practice Nurses. This paper outlines the evaluation methodology, focusing on skill development, retention, and collaborative care. The paper argues for further evaluation of the Hub model to assess its potential as a model of distributed training and education to enhance workforce sustainability in rural healthcare.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1518625"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of ferritinophagy-related genes associated with the prognosis and regulatory mechanisms in non-small cell lung cancer.","authors":"Yuan Hao, Xin Wang, Zerong Ni, Yuhui Ma, Jing Wang, Wen Su","doi":"10.3389/fmed.2025.1480169","DOIUrl":"10.3389/fmed.2025.1480169","url":null,"abstract":"<p><p>Lung cancer remains a major global health issue, with non-small cell lung cancer (NSCLC) constituting approximately 85% of cases. Ferritinophagy, a pivotal autophagic process in ferroptosis, plays an essential role in tumor initiation and progression. However, the specific contributions of ferritinophagy-related genes (FRGs) to NSCLC pathogenesis remain incompletely understood. In this study, weighted gene co-expression network analysis (WGCNA) was employed to identify key modular genes associated with FRG scores. Genes overlapping between these modules and differentially expressed genes (DEGs) were selected for further investigation. Prognostic genes were identified through univariate Cox regression and least absolute shrinkage and selection operator (LASSO) analysis, with subsequent validation using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) on both clinical samples and the TCGA-NSCLC dataset. A nomogram incorporating clinicopathological features and risk scores was developed to predict patient outcomes. Further analyses focused on functional enrichment, drug sensitivity, and the immune microenvironment. Cross-referencing 2,142 key modular genes with 2,764 DEGs revealed 600 candidate genes. Univariate Cox regression and LASSO analysis of these candidates identified eight prognostic genes: KLK8, MFI2, B3GNT3, MYRF, CREG2, GLB1L3, AHNAK2, and NLRP10. Two distinct risk groups exhibited significant survival differences. Both the risk score and pathological N stage were found to be independent prognostic factors, forming the basis for the nomogram. Notable correlations were observed between certain immune cells, prognostic genes, and immune responses, affecting the efficacy of immunotherapy and drug sensitivity. qRT-PCR confirmed that, except for NLRP10, all prognostic genes exhibited expression patterns consistent with TCGA-NSCLC data. This study highlights the significant role of FRGs in NSCLC prognosis and regulation, offering novel insights for personalized treatment strategies.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1480169"},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of integrating medical humanities education into emergency skill-training scenario simulation teaching.","authors":"Hongkun Guo, Huan Li, Yongdong Yao, Yiming Li, Yanjing Huang","doi":"10.3389/fmed.2025.1561504","DOIUrl":"10.3389/fmed.2025.1561504","url":null,"abstract":"<p><strong>Objective: </strong>To explore the value of integrating medical humanities education into emergency skill training scenario simulation teaching.</p><p><strong>Method: </strong>69 first-year professional master's students studying at Fujian Medical University(China) were selected as research subjects. They were randomly divided into control (<i>n</i> = 39) and observation (<i>n</i> = 40) groups. All students received emergency skills training. The control group adopted the scenario simulation teaching method, while the observation group integrated medical humanities education based on the control group. Assessment scores and satisfaction with the teaching mode were compared between the two groups.</p><p><strong>Results: </strong>The observation group outperformed the control group in practical, theoretical, and comprehensive grades, and were more satisfied with the teaching mode, with both differences being statistically significant (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Incorporating medical humanities education into emergency training simulations can enhance teaching quality, boost students' ethical literacy, and improve teaching satisfaction, making it worthy of widespread application.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1561504"},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}