Frontiers in Medicine最新文献

{"title":"18F-FDG PET/CT in xanthogranulomatous cholecystitis with CA199 elevation: diagnostic dilemmas and differentiation strategies.","authors":"Wanling Qi, Min Chen, Mingyan Shao","doi":"10.3389/fmed.2025.1630989","DOIUrl":"10.3389/fmed.2025.1630989","url":null,"abstract":"<p><strong>Objective: </strong>Xanthogranulomatous cholecystitis (XGC) is a rare and distinctive form of chronic cholecystitis, and it is rather challenging to differentiate it from the thick-walled type of gallbladder carcinoma. Considering that computed tomography (CT), magnetic resonance imaging (MRI), and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) each exhibit unique features in the manifestation of XGC, this study aims to deepen the understanding of XGC and explore the roles of these imaging examinations, especially PET/CT, in the diagnosis and differential diagnosis of XGC.</p><p><strong>Methods: </strong>We retrospectively analyzed the radiological, clinical, and surgical pathological data of five patients with XGC treated at Jiangxi Provincial People's Hospital between January 2019 and January 2025.</p><p><strong>Results: </strong>All five patients with XGC were female, aged 49-84 years. Four patients were hospitalized for recurrent abdominal pain, while one presented with limb weakness. Carbohydrate antigen 19-9 (CA19-9) levels were elevated in three patients. Among the cases in this manuscript, one patient underwent contrast-enhanced MRI, two patients underwent contrast-enhanced CT, and all five patients underwent positron emission PET/CT examination. The results of the imaging examinations revealed that the gallbladder volume was enlarged in three cases and reduced in two cases. The gallbladder wall showed thickening to varying degrees (ranging approximately from 1.2 to 2.0 cm), with diffuse thickening observed in three cases and localized thickening in two cases. The enhancement pattern was characterized by progressive and sustained enhancement, and there was an increase in FDG uptake to different extents. Intramural nodules and gallstones were detected in three cases, and enlarged abdominal or retroperitoneal lymph nodes were found in two cases. The range of the maximum standardized uptake value (SUVmax) was between 7.5 and 19.8, and the median uptake value was 10.04 ± 5.75.</p><p><strong>Conclusion: </strong>In light of the insufficient diagnostic accuracy of FDG-PET/CT and CA 19-9 in distinguishing XGC from GBC, future efforts should prioritize the validation and adoption of advanced imaging techniques such as FLT-PET/CT. Pending these developments, radical cholecystectomy performed by experienced surgeons remains the recommended surgical strategy for suspected cases.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1630989"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a predictive model for invasive syndrome in patients with <i>Klebsiella pneumoniae</i> liver abscess.","authors":"Liyong Zhang, Jiaqi Chen, Yihao Qu, Xidong Cao, Jinhua Cui, Jian Li, Aijun Yu","doi":"10.3389/fmed.2025.1663407","DOIUrl":"10.3389/fmed.2025.1663407","url":null,"abstract":"<p><strong>Introduction: </strong>Pyogenic liver abscess (PLA) is a life-threatening liver bacterial infection causing suppurative lesions. In Asia, hypervirulent <i>Klebsiella pneumoniae</i> (hvKP) is the main PLA pathogen, linked to invasive syndromes. Severe <i>Klebsiella pneumoniae</i> liver abscess (KPLA) manifestations, called invasive KPLA syndrome (IKPLAS), have acute onset, rapid progression and non-specific symptoms, often leading to poor prognosis if untreated. This study aimed to find risk factors and create a validated nomogram for predicting invasive syndrome in KPLA patients.</p><p><strong>Methods: </strong>We retrospectively analyzed clinical data from 529 KPLA patients treated at Chengde Medical University Affiliated Hospital between August 1, 2014, and November 30, 2024. By using the 7:3 stratified random sampling method, the patients were assigned to two cohorts: derivation (<i>n</i> = 370) and validation (<i>n</i> = 159). Univariate and multivariate logistic regression analyses were performed to identify risk factors for invasive KPLA syndrome (IKPLAS). A predictive nomogram was constructed and evaluated for discrimination and clinical utility.</p><p><strong>Results: </strong>Of the 529 enrolled patients, 33 patients (6.2%) developed IKPLAS (IKPLAS group), while the remaining 496 patients were included in the non-invasive group (NIKPLAS group). Both groups showed significant differences (<i>P</i> < 0.05) in the incidence of viral hepatitis, biliary disease, type 2 diabetes mellitus (T2DM), vomiting, pulmonary infection, and septic shock; C-reactive protein level; abscess diameter; presence of a gas-containing abscess; and Sequential Organ Failure Assessment (SOFA) score. Multivariate analysis identified the following factors as independent predictors: viral hepatitis, T2DM, abscess diameter, presence of a gas-containing abscess, and SOFA score. The nomogram showed excellent calibration (Hosmer-Lemeshow χ² = 4.171, <i>P</i> = 0.841) with area under the receiver operating characteristic curve values of 0.961 (derivation cohort) and 0.899 (validation cohort). The clinical utility of the nomogram was confirmed by decision curve analysis.</p><p><strong>Conclusion: </strong>Viral hepatitis, T2DM, abscess diameter, presence of a gas-containing abscess, and SOFA score are the predictive factors of IKPLAS. The developed nomogram provides reliable risk stratification for patients with KPLA and can be applied clinically to predict IKPLAS cases.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1663407"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of VEGF, ET-1 and TGF-β1 levels in peritoneal dialysis effluent on peritoneal solute transport function.","authors":"Xinxuan Han, Long Li, Xiangjiang Yu, Yan Jiang, Feifei Li, Shixi Luo, Xingxin Zeng, Ming Zhang","doi":"10.3389/fmed.2025.1548218","DOIUrl":"10.3389/fmed.2025.1548218","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the impact of Vascular endothelial growth factor (VEGF), Endothelin-1 (ET-1), and Transforming growth factor-β1 (TGF-β1) levels in peritoneal dialysis effluent on peritoneal solute transport function.</p><p><strong>Methods: </strong>We included 450 patients from four hospitals, spanning from January 2016 to January 2018. Patients were categorized into low-transport (D/Pcr ≤ 0.65) and high-transport groups (D/Pcr > 0.65) based on solute transport rates. We compared the effluent levels of VEGF, ET-1, and TGF-β1 between the groups, employed Pearson's correlation for analysis, and used multivariate logistic regression to identify independent factors influencing solute transport.</p><p><strong>Results: </strong>VEGF and TGF-β1 levels were significantly higher in the high-transport group (<i>p</i> < 0.05), showing a positive correlation with solute transport function (<i>r</i> = 0.721 and 0.539 respectively, <i>p</i> < 0.05). ET-1 levels showed no significant difference between the groups. VEGF and TGF-β1 were identified as significant independent factors affecting solute transport (OR = 3.438 and 3.684, <i>p</i> < 0.05). ROC curve analysis highlighted the predictive value of VEGF and TGF-β1 for solute transport function. Kaplan-Meier and COX regression analyses indicated that high transport was associated with lower survival rates, with VEGF and TGF-β1 serving as independent risk factors for mortality (RR = 3.442 and 3.550, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>VEGF and TGF-β1 levels in peritoneal dialysis effluent are strongly correlated with solute transport function and serve as significant predictors of patient outcomes.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1548218"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cascaded clinical-ultrasound-biochemical model for precise prediction before thyroid nodule fine-needle aspiration biopsy.","authors":"Shuhang Gao, Bojia Liu, Mengying Tong, Yalin Zhu, Lina Wang, Linyao Du, Chang Shi, Mei Han, Ying Che","doi":"10.3389/fmed.2025.1641266","DOIUrl":"10.3389/fmed.2025.1641266","url":null,"abstract":"<p><strong>Objectives: </strong>Determining the nature of thyroid nodules through a single fine-needle aspiration (FNA) biopsy is not feasible for approximately one-third of patients. We developed a predictive model to assist FNA decision-making and reduce unnecessary FNAs.</p><p><strong>Methods: </strong>This retrospective study consecutively included patients who underwent ultrasound-guided FNA between March 2018 and March 2023. Patients were divided into a training dataset (70%) and a validation dataset (30%). Univariate analysis was performed within the training dataset using Kruskal-Wallis test for continuous variables and chi-square test or Fisher's exact test for categorical variables. Variables with significance were entered into multivariate logistic regression. The prediction model (B-Model) was constructed using a cascaded three-stage logistic regression framework: Stage I distinguished benign from non-benign nodules, Stage II differentiated malignant from non-malignant nodules, Stage III separated follicular neoplasm from indeterminate/atypia nodules. Model performance was assessed in the validation dataset using sensitivity (SEN), specificity (SPE), and accuracy (ACC). The reduction in repeat FNA facilitated by the B-Model was calculated.</p><p><strong>Results: </strong>Training and validation datasets included 1,573 and 672 cases, respectively. The overall SEN, SPE and ACC of the B-Model were 84.7%, 76.7% and 60.1% in the validation dataset. The application of the B-Model reduced the number of patients requiring repeat FNA from 255 to 153, resulting in a 40.0% reduction.</p><p><strong>Conclusion: </strong>The B-Model demonstrated robust predictive performance, facilitating the optimization of pre-FNA diagnostic workflows, significantly reducing unnecessary repeat FNAs, and advancing precision in thyroid nodule management.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1641266"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, risk factors and evolving treatment of severe retinopathy of prematurity in China: a retrospective multicenter cohort study in 70 neonatal intensive care units.","authors":"Xuting Chen, Yu Xu, Yanchen Wang, Juan Du, Falin Xu, Xinyue Gu, Yun Cao, Jianhua Sun, Mingyan Hei, Shoo Lee, Hongping Xia","doi":"10.3389/fmed.2025.1652727","DOIUrl":"10.3389/fmed.2025.1652727","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the current incidence, risk factors and treatment for severe retinopathy of prematurity (ROP) in very preterm infants in China.</p><p><strong>Methods: </strong>This was a descriptive, retrospective cohort study. The study population was very preterm infants admitted to one of the 70 neonatal intensive care units (NICUs) in the Chinese Neonatal Network who underwent ROP screening between January 2019 and December 2020. The primary outcome was severe ROP, defined as type 1 or type 2 ROP. Potential risk factors were identified based on prior evidence and statistical significance. Adjusted odds ratios with 95% confidence intervals were calculated using a multivariable multinomial logistic regression model.</p><p><strong>Results: </strong>This study included 14,670 very preterm infants, among which 17.3% had low-grade ROP, and 8.5% had severe ROP. Treatment was performed in 1,381 (4.7%) eyes of the infants, among which 1,029 (74.5%), 148 (10.7%), and 124 (9.0%) received intravitreal anti-vascular endothelial growth factor injection only, laser treatment only, and vitreoretinal surgery, respectively. Extremely preterm birth (7.61, 95% CI: 6.12-9.46), small for gestational age (SGA; 2.31, 95% CI: 1.71-3.12), outborn status (1.43, 95% CI: 1.22-1.67), 1-min Apgar score < 7 (1.30, 95% CI: 1.11-1.51), >40 days on oxygen (1.70, 95% CI: 1.37-2.10), >28 days on parenteral nutrition (PN; 1.17, 95% CI: 1-1.35), and any inotropes use (2.12, 95% CI: 1.82-2.46) were associated with increased odds of severe ROP. Antenatal steroid use (0.77, 95% CI: 0.66-0.91), large for gestational age (LGA; 0.62, 95% CI: 0.45-0.85), and surfactant treatment (0.75, 95% CI: 0.64-0.87) were associated with reduced odds of severe ROP.</p><p><strong>Conclusion: </strong>The incidence of severe ROP in very preterm infants in China was high compared to the developed countries, and intravitreal anti-VEGF injection was the preferred treatment for severe ROP.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1652727"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between lung function impairment, clinical characteristics and systemic inflammation based on a large-scale population screening.","authors":"Xiaojun Ma, Yan Yu, Wenxia Guan, Shuming Guo, Zhancheng Gao, Mengtong Jin, Peng Liu, Lianyu Cheng, Chunting Chen, Kaiyu Ma, Yujie Zhou, Ran Li, Qi Wu","doi":"10.3389/fmed.2025.1657151","DOIUrl":"10.3389/fmed.2025.1657151","url":null,"abstract":"<p><strong>Background: </strong>Lung function impairment, a hallmark of chronic airway diseases like chronic obstructive pulmonary disease (COPD), is often underdiagnosed in China. Preserved Ratio Impaired Spirometry (PRISm) may represent an early, subclinical stage of this process. However, a comprehensive understanding of their clinical phenotypes, effective predictive strategies for early identification in large populations, and the role of systemic inflammation remains underexplored, particularly in the Chinese context. This study aimed to describe the clinical phenotypes of lung function impairment, identify predictive factors using machine learning, and explore associated systemic inflammation in a large-scale population screening.</p><p><strong>Methods: </strong>A prospective cross-sectional study was conducted in Hongtong County, China (2021-2024). Participants were classified into airflow obstruction, PRISm, and normal groups via portable spirometry. Using demographic, clinical, and laboratory data, we developed and validated several machine learning (ML) models to predict lung function impairment. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC). Serum cytokines were measured by ELISA in matched sub-cohorts to assess systemic inflammation.</p><p><strong>Results: </strong>Among 9,284 enrolled adults, 51.0% had airflow obstruction, 6.7% had PRISm, and 42.3% were normal. We identified distinct phenotypes: the PRISm group was predominantly female with lower smoking rates but a higher risk of coronary heart disease. The airflow obstruction group was characterized by classical risk factors (older age, male sex, lower BMI, smoking) and specific renal and cerebrovascular comorbidities. The ML models identified older age, male sex, lower BMI, respiratory symptoms (cough, dyspnea), and higher creatinine and hemoglobin as key predictors, demonstrating modest performance with an AUC of 0.635 in the validation set. Immunologically, individuals with airflow obstruction or PRISm showed significantly lower serum IL-2 and higher IL-5 and IL-17A levels compared to controls.</p><p><strong>Conclusion: </strong>In a large-scale screening, individuals with airflow obstruction and PRISm present with distinct clinical phenotypes. A predictive model using simple clinical variables can help identify individuals at higher risk for lung function impairment, despite modest performance. Serum IL-2, IL-5, and IL-17A are potential biomarkers for the early recognition and understanding of airflow limitation.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1657151"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of severe pneumonia in respiratory non-intensive care unit: a retrospective study from a single center experience.","authors":"Lucrezia Pisanu, Marianna Russo, Maria Arminio, Lorenzo Arlando, Valentina Conio, Francesco Rocco Bertuccio, Klodjana Mucaj, Mitela Tafa, Giulia Maria Stella, Angelo Guido Corsico","doi":"10.3389/fmed.2025.1666800","DOIUrl":"10.3389/fmed.2025.1666800","url":null,"abstract":"<p><strong>Aim: </strong>Severe pneumonia management in the hospital setting often relies heavily on established clinical practice and physician experience. This approach has the purpose of enabling early identification of risk factors most strongly associated with severe pneumonia at the time of hospital admission.</p><p><strong>Methods: </strong>This retrospective study analyzed inpatients with pneumonia treated in a Respiratory disease unit, stratifying them into two groups-severe and non-severe pneumonia - according to the 2007 IDSA/ATS criteria, identifying differences in demographic profiles, clinical features, treatment strategies, and prognostic outcomes.</p><p><strong>Results: </strong>Out of a cohort of 302 patients, 26 (8.6%) met the criteria for severe pneumonia. A statistically significant difference was observed in the Pneumonia Severity Index (PSI > 90), recorded in 61.53% of patients with severe pneumonia compared to 41.31% in non-severe cases. The Charlson Comorbidity Index (CCI ≥ 4), indicative of lower 10-year survival due to comorbidities, was significantly more frequent in the severe group (84.61% vs. 61.23%). Microbiological analysis of bronchoalveolar lavage (BAL) showed a positivity rate of 75% in the severe group versus 35.48% in the non-severe group (<i>p</i> < 0.05). Significant differences were also found in the use of respiratory support: high-flow nasal cannula (HFNC) was used in 69.23% of severe cases versus 32.97% in non-severe cases, while CPAP was administered in 23.07% versus 5.43%, respectively. Finally, antibiotic therapy was significantly longer in the severe group, with a mean duration of 14.69 days compared to 11.77 days in non-severe patients, involving both intravenous and oral regimens as part of initial or sequential treatment.</p><p><strong>Conclusion: </strong>Timely recognition of these factors is essential to ensure optimal patient care, facilitate close monitoring of critically ill individuals, allow for prompt therapeutic escalation, and support ICU admission when needed. This analysis highlights the need for a critical reassessment of existing guidelines and underscores the value of integrating them with real-world clinical experience.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1666800"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Uterine mesothelial cyst in a nulliparous woman-diagnostic and clinical challenges of a rare benign lesion.","authors":"Ying Shao, Yi Liu, Chun Yang","doi":"10.3389/fmed.2025.1672439","DOIUrl":"10.3389/fmed.2025.1672439","url":null,"abstract":"<p><p>Uterine mesothelial cysts (UMCs) are rare, benign lesions that arise from the mesothelial lining of the uterus and are only sporadically documented in the literature. Because of their extremely low incidence, the clinical presentation and imaging features of UMCs are often nonspecific, which makes preoperative diagnosis particularly challenging. We report the case of a 46-year-old nulliparous woman who presented with an intramural cystic mass of the uterus. Preoperative imaging suggested a benign lesion, but the differential diagnosis included cystic degeneration of leiomyoma, adenomyotic cyst, and endometriosis. The patient underwent a laparoscopic cystectomy, during which the cyst was completely excised without intraoperative complications. She recovered uneventfully and was discharged on postoperative day three. Histopathological examination confirmed the diagnosis of a uterine mesothelial cyst. At 1 month of follow-up, no recurrence was observed. This case highlights the importance of surgical excision for both definitive diagnosis and treatment, emphasizes the challenges in preoperative assessment, and contributes valuable clinical evidence to the limited body of knowledge on UMCs.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1672439"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the AGEs-RAGE axis: pathogenic mechanisms and therapeutic interventions in diabetic wound healing.","authors":"Haohui Lin, Yi Yang, Xia Wang, Manhon Chung, Li Zhang, Sa Cai, Xiaohua Pan, Yu Pan","doi":"10.3389/fmed.2025.1667620","DOIUrl":"10.3389/fmed.2025.1667620","url":null,"abstract":"<p><p>Diabetes is a global health problem, with diabetic wounds constituting one of its most severe complications. Advanced glycation end products (AGEs) and their receptor, the receptor for advanced glycation end products (RAGE), play a key role in the pathogenesis of diabetic wounds. Accumulated AGEs bind to RAGE, activating various inflammatory and oxidative stress pathways such as NF-κB, PI3K-AKT, and JAK-STAT signaling, impairing normal wound healing. This review describes mechanisms by which the AGEs-RAGE axis disrupts vascular function, immune regulation, and cellular regeneration, thereby driving the formation of chronic non-healing wounds. Furthermore, we discuss emerging therapeutic strategies targeting the AGEs-RAGE axis, such as selective RAGE inhibitors, monoclonal antibodies, gene-based interventions, and AGE scavengers, highlighting their potential to enhance the treatment of diabetic chronic wounds.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1667620"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Artificial intelligence-assisted medical imaging solutions for integrating pathology and radiology automated systems, volume II.","authors":"Prabhishek Singh, Vinayakumar Ravi, Anchit Bijalwan","doi":"10.3389/fmed.2025.1686859","DOIUrl":"https://doi.org/10.3389/fmed.2025.1686859","url":null,"abstract":"","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1686859"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}