Frontiers in Medicine最新文献

{"title":"Imaging findings for 2-[¹⁸F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in blastic plasmacytoid dendritic cell neoplasm: case series and literature review.","authors":"Yujing Zhou, Kaiyue Li, Xin Jin, Lujie Yuan, Hang Zhou, Xin Li","doi":"10.3389/fmed.2025.1581760","DOIUrl":"10.3389/fmed.2025.1581760","url":null,"abstract":"<p><p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with a poor prognosis. The value of 2-[¹⁸F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in BPDCN has not been clarified. This study aimed to investigate the imaging findings of ¹⁸F-FDG PET/CT in patients with BPDCN based on cases from our institution and the literature. The clinical and radiological data were obtained from five patients with BPDCN from our institution between March 2014 and July 2023. Additionally, we complemented our dataset with 13 cases derived from the studies published in English to ascertain the potential efficacy of ¹⁸F-FDG PET/CT scan in identifying this malignancy. Information collected included age, sex, extent of lesion involvement, biopsy site, karyotype, immunophenotype, treatment, prognosis, and ¹⁸F-FDG PET/CT-features. A total of 18 cases of BPDCN featuring PET/CT manifestations were assessed. We observed considerably increased ¹⁸F-FDG uptake in lesions of all 18 cases [maximum standardized uptake value (SUV_max), 9.1; range, 1.5-9.1]. The positive findings of ¹⁸F-FDG PET/CT mainly included skin (11/18), lymph nodes (9/18), bone (4/18), and spleen (2/18). Except for these organs, abnormal ¹⁸F-FDG uptake lesions were detected in the lung and breast. The roles of ¹⁸F-FDG PET/CT in our study were initial staging (18/18), selection of biopsy site (5/18), and treatment evaluation (7/18). Prognostic data were available in 16 patients. The median overall survival (OS) in this cohort was 12.0 months, and the median follow-up time was 10.0 months. Among these, 10 cases reported SUV_max of lesions at the same time. Five out of eight patients with SUV_max > 2.5 died within 2 months of diagnosis, whereas two other cases with SUV_max < 2.5 survived within 10 and 34 months of follow-up. The data from our case series and those from the literature demonstrated the potential utility of ¹⁸F-FDG PET/CT in diagnosis, staging, prognosis, and treatment follow-up of BPDCN. Early identification of this rare malignancy on imaging can expedite diagnosis and facilitate early treatment.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1581760"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of Epimedium in the treatment of primary osteoporosis: a systematic review and meta-analysis.","authors":"Xian-Quan Zhang, Zhen-Hui Hua, Chu-Jia Huang, Hai-Yun Chen, Zong-Ren Hu, Mei-Ren Zhang, Jun Liu","doi":"10.3389/fmed.2025.1675160","DOIUrl":"10.3389/fmed.2025.1675160","url":null,"abstract":"<p><strong>Background: </strong>Primary Osteoporosis (POP) is a global public health issue, and traditional medications have long-term safety concerns. Epimedium, a kidney-tonifying traditional Chinese medicine (TCM), has the potential to regulate bone metabolism through multiple targets, but clinical evidence is scattered and inconclusive.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aim to evaluate the efficacy and safety of Epimedium and its active components in treating POP.</p><p><strong>Method: </strong>Computer searches were conducted in multiple domestic and international databases, including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Database, to collect randomized controlled trials (RCTs) comparing the use of Epimedium as an adjunct or alternative therapy with traditional drug treatments for POP. Literature was screened according to predefined inclusion and exclusion criteria, quality assessments were performed on eligible articles, relevant data were extracted, and statistical analysis was conducted using RevMan 5.4 software.</p><p><strong>Results: </strong>A total of 10 RCTs were included, with a final inclusion of 890 cases, 448 in the experimental group and 442 in the control group. Meta-analysis suggests that the overall efficacy rate of the Epimedium group was significantly higher than that of the control group (OR = 3.80; 95% CI: 2.27,6.37; <i>p</i> = 0.0001). Compared with the control group, Epimedium group's Lumbar vertebra bone mineral density (BMD) (SMD = 1.15; 95% CI: 0.61,1.70; <i>p</i> < 0.0001), Femoral neck BMD (SMD = 1.11; 95% CI: 0.58,1.65; <i>p</i> < 0.0001), Distal radius BMD (SMD = 1.27; 95% CI: 0.57,1.98; <i>p</i> = 0.0004), and Metacarpal BMD (MD = 0.04; 95% CI: 0.04,0.12; <i>p</i> < 0.0001) all showed significant improvement, with a shorter time to relief of lower back pain (MD = -11.38; 95% CI: -12.63, -10.12; <i>p</i> < 0.00001). Serum alkaline phosphatase (ALP) was significantly reduced (MD = -8.78; 95% CI: -12.80, -4.77; <0.0001), while bone-specific alkaline phosphatase (BALP) increased (MD = 6.73; 95% CI: 3.32,10.14; <i>p</i> = 0.0001). Adverse reactions were low, mainly mild gastrointestinal reactions or skin allergies.</p><p><strong>Conclusion: </strong>Epimedium can effectively improve bone density and clinical symptoms in patients with POP, with good safety, making it a potential alternative or adjunctive treatment option, but more high-quality studies are needed to verify long-term efficacy.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1675160"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond metropolises: artificial intelligence awareness and educational needs among medical students in a developing country.","authors":"Emre Sanri","doi":"10.3389/fmed.2025.1645484","DOIUrl":"10.3389/fmed.2025.1645484","url":null,"abstract":"<p><strong>Background: </strong>While artificial intelligence (AI) is rapidly transforming healthcare, medical curricula have not fully adapted to this transformation, particularly in developing countries. This gap is especially pronounced in non-metropolitan regions, where resources and exposure to technology may be more limited. Understanding the perspectives of medical students in these specific contexts is vital for designing effective and equitable educational strategies.</p><p><strong>Objective: </strong>This study evaluated the knowledge, awareness, attitudes, and educational expectations of students at a newly established Turkish medical school, located in a non-metropolitan city, regarding AI and digital health technologies.</p><p><strong>Methods: </strong>A descriptive, cross-sectional survey was conducted among first- to fourth-year students at Samsun University Faculty of Medicine. Data were collected from 198 participants, and a stratified random sample of 120 students was selected for analysis. The questionnaire covered demographics, digital literacy, AI knowledge, and attitudes toward its integration into the curriculum.</p><p><strong>Results: </strong>The majority of students rated their digital competence as moderate (59.2%) or low (19.2%). Interest in technology was highest among first-year students (60%) but declined significantly to 13.3% by the fourth year. Knowledge of AI was generally limited, with only 15.8% reporting a high level of knowledge and 55.0% stating they conducted little or no independent research on AI. Despite these deficiencies, students expressed strong support for AI integration: 78.3% supported AI-assisted interactive tools, 79.2% endorsed personalized learning, and 80% acknowledged the role of AI in clinical decision-making processes. The majority of students (82.5%) advocated for a broader integration of AI, stating that their top priority was its integration into clinical practice (39.2%).</p><p><strong>Conclusion: </strong>Offering a rare perspective from a non-metropolitan city in a developing country, this study reveals that medical students exhibit high motivation for AI integration despite significant knowledge gaps. This enthusiasm presents a critical opportunity for curriculum reform. There is an urgent need for context-appropriate AI curricula to bridge the gap between student interest and preparedness, thereby empowering the next generation of physicians in diverse settings for the future of digital healthcare.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1645484"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI findings of pancreatic intraductal oncocytic papillary neoplasm: three case reports and review of literature.","authors":"Yunan Xiang, Xiaojun Chen, Xiafei Zhan, Zhihan Yan, Jiangfeng Pan, Xinyu Wang","doi":"10.3389/fmed.2025.1650931","DOIUrl":"10.3389/fmed.2025.1650931","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic intraductal oncocytic papillary neoplasms (IOPNs) are uncommon precancerous lesions frequently mistaken for other tumors because of their similar imaging characteristics. The concept of IOPN was first proposed by Adsay et al. in 1996. Recently, an increasing number of reviews on IOPN have been published, however, literature focusing on its imaging features remains scarce. This study retrospectively analyzed the clinical, imaging, and pathological data of three patients with pathologically confirmed pancreatic IOPN, alongside a review of the latest findings in relevant literature.</p><p><strong>Case presentation: </strong>We described three cases of IOPN in elderly patients, with a male-to-female ratio of 1:2. Among these cases, only one patient exhibited abdominal pain, while the other two were asymptomatic. MRI revealed clearly defined mixed-signal masses in the pancreatic head or tail in each case, with the solid components showing moderate enhancement progressively on contrast imaging. After undergoing surgical treatment, all three patients showed no significant clinical symptoms or recurrence signs during follow-up evaluations over 4-6 months.</p><p><strong>Conclusion: </strong>Our article provides preliminary evidence of MRI characteristics in pancreatic IOPN, which are essential for understanding its imaging features and aiding in differential diagnosis.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1650931"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Predictors of breakthrough invasive fungal infections (BIFI) in pediatric acute leukemia: a retrospective analysis and predictive model development.","authors":"Yan Li, Lijun Qu, Jian Wang, Pingtian Chen, Aoshuang Jiang, Hongjun Liu","doi":"10.3389/fmed.2025.1692510","DOIUrl":"https://doi.org/10.3389/fmed.2025.1692510","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmed.2024.1488514.].</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1692510"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A localized vertebral infection model of pyogenic spondylitis induced by <i>Staphylococcus aureus</i> in rats.","authors":"Qinpeng Xu, Guihe Yang, Jiaju Ma, Xingzhi Jing, Fei Jia, Xingang Cui, Jianlong Li, Xiaoyang Liu, Hongdong Tan","doi":"10.3389/fmed.2025.1643905","DOIUrl":"10.3389/fmed.2025.1643905","url":null,"abstract":"<p><strong>Background and purpose: </strong>Pyogenic spondylitis (PS) is clinically challenging and induces disastrous consequences for patients. The pathogenesis of PS is difficult to explore due to a lack of ideal animal models. Thus, we aimed to reproduce the local pathogenesis of PS in an innovative animal model induced by <i>Staphylococcus aureus</i>.</p><p><strong>Methods: </strong>Rats were injected with planktonic <i>Staphylococcus aureus</i> (ATCC 25923) and grouped according to different concentrations. We identified the optimal bacterial inoculum concentration based on general physical signs and radiological, hematological, and histological parameters in rats. Models with the optimal bacterial concentration were used to investigate changes in physical, radiological, and inflammatory parameters at different time points.</p><p><strong>Results: </strong>Our results revealed that infected rats experienced rapid weight loss, high fever, and significantly increased white blood cell count, interleukin 1β, and C-reactive protein (CRP) levels in the short term. Radiographic examination revealed bone damage in groups that received 2 × 10³/20 μl, 2 × 10⁵/20 μl and 2 × 10⁷/20 μl bacterial concentrations. The optimal concentration was identified as 2 × 10⁵/20 μl, based on the high survival rate, obvious bone destruction, and inflammation. Histological staining confirmed the living bacteria, inflammatory cells, bone destruction, and scarce bone formation in infected vertebrae.</p><p><strong>Conclusions: </strong>This study provides an innovative PS animal model that simulates a local iatrogenic vertebral infection and develops innovative and effective strategies for its treatment, but does not simulate the hematogenous dissemination characteristics of most clinical cases of pyogenic spondylitis.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1643905"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in mesenchymal stem cell-derived extracellular vesicles clinical trials 2014-2024: is efficacy optimal in a narrow dose range?","authors":"Yusong Wang, Junchi Zhu, Qimin Ma, Wei Zhou, Linshan Yang, Shuyue Sheng, Feng Zhu, Zhaofan Xia","doi":"10.3389/fmed.2025.1625787","DOIUrl":"10.3389/fmed.2025.1625787","url":null,"abstract":"<p><strong>Background: </strong>Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are emerging as promising cell-free therapeutic agents due to their immunomodulatory and regenerative properties. However, the lack of standardized protocols and dose optimization strategies has limited their clinical translation. While procedures for the isolation, expansion, and therapeutic use of mesenchymal stem cells (MSCs) have been standardized, there remains a lack of standardized protocols for the isolation and purification of EVs and exosomes (Exos).</p><p><strong>Methods: </strong>This review Comprehensive statistical summary global clinical trials involving MSC-EVs and Exos registered between 2014 and 2024, with a particular focus on dose-effect relationships and administration routes. Data were collected from ClinicalTrials.gov, the Chinese Clinical Trial Registry, and the Cochrane Register of Studies. A total of 66 eligible trials were included after screening.</p><p><strong>Results: </strong>Intravenous infusion and aerosolized inhalation were identified as the predominant administration methods, especially in trials targeting respiratory diseases. Notably, dose-effect results revealed that nebulization therapy achieved therapeutic effects at doses around 108 particles, significantly lower than those required for intravenous routes. This suggests a relatively narrow and route-dependent effective dose window. However, large variations in EVs characterization, dose units, and outcome measures were observed across trials, underscoring the lack of harmonized reporting standards.</p><p><strong>Conclusion: </strong>This review highlights dose-response as a critical but underappreciated gap in current MSC-EVs clinical research. The findings emphasize the urgent need for standardized dosing frameworks, potency assays, and harmonized clinical protocols to advance the safe and effective translation of MSC-EVs therapies. The analysis underscores the need for standardized protocols, global collaboration, and a deeper understanding of the biological mechanisms underlying MSC-EVs and Exos therapies to advance clinical applications and ensure safety and efficacy.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1625787"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombotic microangiopathy with irreversible renal function in a CKD patient following COVID-19: case report.","authors":"Yunlong Qin, Xinjun Yang, Wei Zhao, Yuzhe Li, Yaling Bai, Lihui Wang","doi":"10.3389/fmed.2025.1484385","DOIUrl":"10.3389/fmed.2025.1484385","url":null,"abstract":"<p><p>We report a case of chronic kidney disease (CKD), in a patient with normal renal function, diagnosed as acute renal failure stage 3 after coronavirus disease 2019 (COVID-19)-associated thrombotic microangiopathy (TMA) characterized by the presence of thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The results of the renal biopsy were thickening of the small artery wall with mucous edema, endothelial swelling and hyperplasia, and segmental endothelial onion-like hyperplasia. However, the pathogenesis factors of the patient who suffered from COVID-19-associated TMA were not clear, although blood complements, activity of ADAMTS13, and Factor H were detected as normal. After the administration of pulse glucocorticoid, plasma exchange, and hemodialysis, the patient developed chronic renal failure and depended on peritoneal dialysis 12 months later. Although the clinical manifestations of TMA are similar, the etiology and pathogenesis are very complex. It is very important to determine the pathogenesis of TMA to proceed with precise treatment to improve the prognosis of the patient.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1484385"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of serum interleukin-33 and thymic stromal lymphopoietin for the risk of acute exacerbation in patients with chronic obstructive pulmonary disease.","authors":"Shijia Yin, Kang Xu, Shi Wu, Hua Liu, Zhen Ding","doi":"10.3389/fmed.2025.1592734","DOIUrl":"10.3389/fmed.2025.1592734","url":null,"abstract":"<p><strong>Background: </strong>Acute exacerbation in patients with chronic obstructive pulmonary disease (COPD) lacks reliable biomarkers. This study aimed to explore the predictive value of serum interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) for acute exacerbations of COPD (AECOPD).</p><p><strong>Methods: </strong>This retrospective study included patients with stable-phase COPD between June 2023 and June 2024 at the Third Affiliated Hospital of Anhui Medical University. Patients were assigned to the low-risk and high-risk groups according to the number and severity of AECOPD events. Multivariable logistic regression analysis was used to identify the factors of AECOPD risk. Receiver operating characteristic (ROC) curves were used to assess the predictive value of IL-33 and TSLP for AECOPD risk.</p><p><strong>Results: </strong>A total of 76 patients were enrolled, with 33 in the low-risk group and 43 in the high-risk group. Serum IL-33 (835.30 vs. 770.30, <i>p</i> = 0.008) and TSLP (102.20 vs. 90.45, <i>p</i> < 0.001) levels were higher in the high-risk group than in the low-risk group. Serum TSLP (odds ratio (OR) = 1.095, 95% confidence interval (CI): 1.013-1.184, <i>p</i> = 0.022) was independently associated with AECOPD. The area under the curve (AUC) for IL-33 in predicting AE was 0.677 (95%CI: 0.554-0.801), with 93.0% sensitivity and 39.4% specificity. The AUC for TSLP was 0.768 (95%CI: 0.659-0.878), with 76.7% sensitivity and 72.7% specificity. Combined prediction using IL-33 and TSLP yielded an AUC of 0.779 (95%CI: 0.669-0.888), with 81.4% sensitivity and 72.7% specificity.</p><p><strong>Conclusion: </strong>High serum TSLP might be associated with an increased risk of AECOPD. While IL-33 alone showed high sensitivity and low specificity, its potential predictive value may be worth exploring.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1592734"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep matters: the U-shaped relationship between sleep duration and overactive bladder in U.S. adults.","authors":"Ciyi Guan, Lei Wang, Chao Wang, Yinhua Ma, Yinjiao Chen, Junjun Wu, Hui Pan, Chang Zhang, Haiyuan Song","doi":"10.3389/fmed.2025.1612280","DOIUrl":"10.3389/fmed.2025.1612280","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the independent and combined associations of sleep duration and sleep disorders with the risk of overactive bladder (OAB) and identify threshold effects of sleep duration on OAB.</p><p><strong>Methods: </strong>Data from the NHANES (2005-2018) were analyzed, including 27,302 adults, among whom 5,601 (20.5%) were diagnosed with OAB. Associations between sleep duration (≤ 6 h, > 6 to < 9 h, ≥ 9 h), sleep disorders, and OAB risk were assessed using multivariable logistic regression, restricted cubic splines (RCS), and smooth curve fitting, adjusting for demographic, socioeconomic, lifestyle, and health-related covariates.</p><p><strong>Results: </strong>A significant non-linear, U-shaped relationship between sleep duration and OAB risk was observed. Compared to individuals with a sleep duration of 6-9 h, those with short sleep duration (≤ 6 h) had a slightly lower risk of OAB (OR = 0.94), while those with long sleep duration (≥ 9 h) had a significantly higher risk (OR = 2.54). Self-reported sleep disorders independently elevated the risk of OAB (OR = 1.46). RCS analysis identified 6 h of sleep as a critical inflection point.</p><p><strong>Conclusion: </strong>This study reveals a U-shaped relationship between sleep duration and the risk of overactive bladder (OAB), with both short (≤ 6 h) and long (≥ 9 h) sleep durations increasing OAB risk. These findings highlight the importance of sleep management in OAB care. Behavioral interventions, including sleep hygiene education and bladder training, may help mitigate symptoms and improve patient outcomes.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1612280"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}