Frontiers in Medicine最新文献

{"title":"Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis.","authors":"Lin Bai, Fangyuan Xu, Peijia Hu, Zhiqiang Shen, Su Xingxing, Qingqing Wang, Hongliang Cheng","doi":"10.3389/fmed.2024.1432455","DOIUrl":"10.3389/fmed.2024.1432455","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment (CI) endangers the physical and mental health of patients in a significant manner, and it is expected that the number of people with CI in China will rise to 45.33 million by 2050. Therefore, CI has become a popular research topic. Inflammatory damage plays a key role in the pathogenesis of CI, and NF-κB is an important inflammatory signaling pathway. However, no bibliometric analysis regarding the relationship between CI and NF-κB has been reported.</p><p><strong>Methods: </strong>A bibliometric analysis regarding NF-κB and CI from 1 January 2008 to 12 December 2023 was conducted in the Science Citation Index-Expanded of the Web of Science Core Collection. The frontiers, hotspots, and trends of research regarding the role of NF-κB in CI were identified. VOSviewer and CiteSpace were used to analyze the retrieved articles and identify the author, country, institution, and keywords, as well as co-cited authors, co-cited journals, and co-cited references.</p><p><strong>Results: </strong>We analyzed 1,468 original articles and reviews. Publications on NF-κB in CI began in 2010 and increased sharply in 2018. Hong Hao was the most represented author, having published 19 articles, and Chinese authors published more studies than those from other countries. China Pharmaceutical University published the most papers; however, the United States has a strong influence and demonstrates international cooperation. The keywords \"apolipoprotein e\" and \"therapeutic target\" demonstrated strong citation bursts, and this tendency may persist in the upcoming years. Neuroinflammation demonstrated a strong influence in research regarding NF-κB in CI. Gut microbiota and ketogenic diet also play an important role in NF-κB in CI.</p><p><strong>Conclusion: </strong>This bibliometric analysis and visualization using VOSviewer and CiteSpace revealed that the role of NF-κB in CI has become a research hotspot. The results of this study indicated that \"neuroinflammation,\" \"microglial,\" and \"pathway\" remain hotspots for future research. However, studies regarding NF-κB in CI have predominantly focussed on basic research; future research should include therapeutic targets, microbiota, and ketogenic diet.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1432455"},"PeriodicalIF":3.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection of Alzheimer's disease in structural and functional MRI.","authors":"Rudrani Maity, Vellupillai Mariappan Raja Sankari, Umapathy Snekhalatha, Shubashini Velu, Tahani Jaser Alahmadi, Zaid Ali Alhababi, Hend Khalid Alkahtani","doi":"10.3389/fmed.2024.1520878","DOIUrl":"10.3389/fmed.2024.1520878","url":null,"abstract":"<p><strong>Objectives: </strong>To implement state-of-the-art deep learning architectures such as Deep-Residual-U-Net and DeepLabV3+ for precise segmentation of hippocampus and ventricles, in functional magnetic resonance imaging (fMRI). Integrate VGG-16 with Random Forest (VGG-16-RF) and VGG-16 with Support Vector Machine (VGG-16-SVM) to enhance the binary classification accuracy of Alzheimer's disease, comparing their performance against traditional classifiers.</p><p><strong>Method: </strong>OpenNeuro and Harvard's Data verse provides Alzheimer's coronal functional MRI data. Ventricles and hippocampus are segmented using a Deep-Residual-UNet and Deep labV3+ system. The functional features were extracted from each segmented component and classified using SVM, Adaboost, Logistic regression, and VGG 16, DenseNet-169, VGG-16-RF, and VGG-16-SVM classifier.</p><p><strong>Results: </strong>This research proposes a precise and efficient deep-learning architecture like DeepLab V3+ and Deep Residual U-NET for hippocampus and ventricle segmentation in detection of AD. DeepLab V3+ has produced a good segmentation accuracy of 94.62% with Jaccard co-efficient of 85.5% and dice co-efficient of 84.75%. Among the three ML classifiers used, SVM has provided a good accuracy of 93%. Among some DL techniques, VGG-16-RF classifier has given better accuracy of 96.87%.</p><p><strong>Conclusion: </strong>The novelty of this work lies in the seamless integration of advanced segmentation techniques with hybrid classifiers, offering a robust and scalable framework for early AD detection. The proposed study demonstrates a significant advancement in the early detection of Alzheimer's disease by integrating state-of-the-art deep learning models and comprehensive functional connectivity analysis. This early detection capability is crucial for timely intervention and better management of the disease in neurodegenerative disorder diagnostics.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1520878"},"PeriodicalIF":3.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberous sclerosis: a survey in the canton of Vaud, Switzerland.","authors":"Olivia Hagon-Nicod, Florence Fellmann, Jan Novy, Sébastien Lebon, Christian Wider, Romain Lazor, Olivier Bonny","doi":"10.3389/fmed.2024.1513619","DOIUrl":"10.3389/fmed.2024.1513619","url":null,"abstract":"<p><strong>Aim of the study: </strong>Tuberous sclerosis complex (TSC) is a genetic and multisystemic disorder that affects between 1/6'000 and 1/10'000 of newborns. Clinical criteria and/or genetic analysis establish the diagnosis. The mechanistic target of rapamycin (mTOR) inhibitors everolimus or sirolimus reduce the severity of several TSC-related clinical traits. We report here on the epidemiology and management of TSC patients in a large Swiss canton: the canton of Vaud.</p><p><strong>Method: </strong>We extracted patient files containing the diagnostic code TSC in 2015 at the Lausanne University hospital (tertiary reference center for a population of about 755'000 people) and in specialized neurological institutions of the same region.</p><p><strong>Results: </strong>We identified 52 patients with a diagnosis of TSC. The majority of the patients with a pathologic result in genetic testing were positive for a pathogenic variant in the <i>TSC2</i> gene, including five cases of contiguous gene deletion syndrome of <i>TSC2</i> and <i>PKD1</i> causing both polycystic kidney disease and TSC. The most frequent clinical manifestations encountered were affecting the skin (87% of patients), the brain (83%), the heart (46%) and the kidneys (46%). Neuropsychiatric disorders were described in 56% of cases. At the time of data collection (2015), there were 2 patients using systemic mTOR inhibitors and 16 patients using topical mTOR inhibitors for dermatological features. Next, we compared this data with those of large published cohorts. While we found fewer cases than expected for the screened population, demographic as well as genetic data were overall similar to the literature. However, we observed that some clinical manifestations (renal, lung and neuropsychiatric disorders) were less frequently described in our cohort.</p><p><strong>Conclusion: </strong>This work indicates that TSC and some of its clinical manifestations is under-reported. It raises concern that patients with mild manifestations are often not referred to reference centers with dedicated multidisciplinary group. The follow-up by expert board is instrumental in offering systematic screening of all putatively affected organs and to assess the eligibility for targeted treatment.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1513619"},"PeriodicalIF":3.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic survival prediction of end-stage kidney disease using random survival forests for competing risk analysis.","authors":"Daniel Christiadi, Kevin Chai, Aaron Chuah, Bronwyn Loong, Thomas D Andrews, Aron Chakera, Giles Desmond Walters, Simon Hee-Tang Jiang","doi":"10.3389/fmed.2024.1428073","DOIUrl":"10.3389/fmed.2024.1428073","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>A static predictive model relying solely on baseline clinicopathological data cannot capture the heterogeneity in predictor trajectories observed in the progression of chronic kidney disease (CKD). To address this, we developed and validated a dynamic survival prediction model using longitudinal clinicopathological data to predict end-stage kidney disease (ESKD), with death as a competing risk.</p><p><strong>Methods: </strong>We trained a sequence of random survival forests using a landmarking approach and optimized the model with a pre-specified prediction horizon of 5 years. The predicted cumulative incidence function (CIF) values were used to generate a personalized dynamic prediction plot.</p><p><strong>Results: </strong>The model was developed using baseline demographics and 13 longitudinal clinicopathological variables from 4,950 patients. Variable importance analysis for ESKD and death informed the creation of a sequence of reduced models that utilized six key variables: age, serum albumin, bicarbonate, chloride, eGFR, and hemoglobin. The models demonstrated robust predictive performance, with a median concordance index of 84.84% for ESKD and 84.1% for death. The median integrated Brier scores were 0.03 for ESKD and 0.038 for death across all landmark times. External validation with 8,729 patients confirmed these results.</p><p><strong>Conclusion: </strong>We successfully developed and validated a dynamic survival prediction model using common longitudinal clinicopathological data. This model predicts ESKD with death as a competing risk and aims to assist clinicians in dialysis planning for patients with CKD.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1428073"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling <i>in vivo</i> and <i>in vitro</i>.","authors":"Jiancheng Lin, Zetao Pan, Jiayan Sun, Xiaowan Wang, Di Yin, Cunyang Huo, Qiang Guo","doi":"10.3389/fmed.2024.1509168","DOIUrl":"10.3389/fmed.2024.1509168","url":null,"abstract":"<p><strong>Background: </strong>The co-occurrence of pulmonary hypertension (PH) in patients with pulmonary fibrosis (PF) is linked to a more unfavorable prognosis and increased mortality compared to PF cases without PH. Early intervention and comprehensive management are pivotal for improving survival outcomes. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein essential in cholesterol metabolism. However, the potential for PCSK9 inhibition to alleviate PF-induced PH has not been previously reported.</p><p><strong>Methods: </strong>A mouse model of PF-induced PH was established using intratracheal injection of bleomycin (BLM), followed by administration of a PCSK9 inhibitor every other day. Data on right ventricle (RV) remodeling and changes in pulmonary arteries were collected and analyzed. Transforming growth factor-beta (TGF-β) was also administered to MLE-12 cells as an experimental lung fibrosis model. The mechanisms of PCSK9's impact on lung fibrosis were examined both <i>in vivo</i> and <i>in vitro</i>.</p><p><strong>Results: </strong>Inhibition of PCSK9 significantly reduced pulmonary artery thickening and RV remodeling in the BLM-induced mouse model. Moreover, the blockage of PCSK9 effectively attenuated the migration and epithelial-mesenchymal transition (EMT) process of TGF-β-induced MLE-12 cells. We also observed that the PCSK9 inhibitor suppressed the expression of the Wnt/β-catenin pathway in both animal and cell experiments.</p><p><strong>Conclusion: </strong>PCSK9 plays a crucial role in the progression of PF-induced PH by regulating cell EMT and Wnt/β-catenin signaling. Targeting PCSK9 expression or activity could effectively control lung fibrosis and its PH complication.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1509168"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of osteopenia in adults with short bowel syndrome: a retrospective longitudinal cohort study.","authors":"Guangming Sun, Yufei Xia, Haoyang Wang, Yaqin Xiao, Li Zhang, Yupeng Zhang, Xuejin Gao, Xinying Wang","doi":"10.3389/fmed.2024.1422596","DOIUrl":"10.3389/fmed.2024.1422596","url":null,"abstract":"<p><strong>Background: </strong>Metabolic Bone Disease (MBD) is common in patients with short bowel syndrome (SBS). This study was to investigate the incidence and risk factors of osteopenia in adult SBS patients.</p><p><strong>Methods: </strong>Hospital records from January 2010 to December 2019 were used to identify all eligible patients. Logistic regression and a nomogram were used to analyze the data.</p><p><strong>Results: </strong>A total of 120 patients with SBS were included in this study, and 76 patients (63.3%) developed osteopenia during the 10-year observation period, The multivariate analysis using the logistic regression model demonstrated that age (OR = 1.070; 95%CI: 1.016-1.126, <i>p</i> = 0.010), female (OR = 5.098; 95%CI: 1.211-21.456, <i>p</i> = 0.026), tumor history (OR = 4.481; 95%CI: 1.125-17.854, <i>p</i> = 0.033), duration of SBS (OR = 1.0862; 95%CI: 1.022-1.103, <i>p</i> = 0.002) and remnant ileum (OR = 4.260; 95%CI: 1.210-15.002, <i>p</i> = 0.024) were independent risk factors for osteopenia in adults with SBS. The area under the curve (AUC) for the joint model (age, female, tumor history, duration of SBS, remnant ileum) was 0.848 and the corresponding sensitivity and specificity were 0.855 and 0.705, respectively. The C-index was 0.849 (95% CI: 0.778-0.917); thus, the predictions made by the model were close to the actual outcomes. In the decision curve analysis, the nomogram performed well and was feasible to make beneficial clinical decisions.</p><p><strong>Conclusion: </strong>This study reveals the high prevalence of osteopenia in SBS patients and highlights the importance of early identification and treatment of osteopenia. A nomogram may provide personalized prediction and guidance for medical intervention.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1422596"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand grip strength and all-cause mortality risk in individuals with decreased bone mass: a study from NHANES database.","authors":"Hongdong Sun, Jiayi Liu, Ruirui Tan, Xiaomei Zhang, Xin Qian, Chenxi Qi, Wei Qi","doi":"10.3389/fmed.2024.1452811","DOIUrl":"10.3389/fmed.2024.1452811","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have demonstrated that grip strength is associated with various health outcomes, including osteoporosis. However, the impact of grip strength on long-term mortality risk among individuals with low bone mass remains unclear. This study aims to investigate the association between grip strength and the risk of all-cause mortality in the population with low bone mass.</p><p><strong>Methods: </strong>We included 1,343 cases of decreased bone mass from the NHANES database spanning 2013 to 2014. All-cause mortality data were ascertained through linkage with national death index records up to December 31, 2015. Analysis was conducted using the Cox proportional hazards regression model, and we assessed result reliability through various model adjustments and hierarchical analyses, Schoenfeld's global and individual tests are utilized to estimate the time-varying covariance in the Cox proportional hazards regression model's hypothesis.</p><p><strong>Results: </strong>Throughout an average follow-up period of 69.5 months, 148 deaths were documented. After adjusting for covariates, a significant association between grip strength and the risk of all-cause mortality was observed in individuals with decreased bone mass (HR = 0.9, 95% CI: 0.87-0.93, <i>p</i> < 0.001). Individuals with normal grip strength, compared to those with low grip strength, exhibited a 56% lower risk of all-cause mortality (HR = 0.44, 95% CI: 0.29-0.67, <i>p</i> < 0.001). Various models consistently demonstrated similar significant trends post-adjustment. Subgroup analysis revealed an interaction between grip strength and coronary heart disease (<i>p</i> < 0.05). Schoenfeld's global and individual tests confirmed the reliability of the model (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Our findings indicate that low grip strength is associated with increased all-cause mortality risk in individuals with decreased bone mass. The inclusion of routine monitoring of grip strength in patients with osteopenia and the encouragement of maintaining or improving grip strength in this population may offer a novel approach to health management for these individuals.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1452811"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the mechanism of core acupoints in electroacupuncture for functional constipation based on data mining and network acupuncture.","authors":"Shun Seng Ong, Ting Tang, Lianjie Xu, Canwei Xu, Qi Li, Xiaoyue Deng, Peihua Shen, Yi Chen, Yang Song, Hai Lu, Ling Fang","doi":"10.3389/fmed.2024.1482066","DOIUrl":"10.3389/fmed.2024.1482066","url":null,"abstract":"<p><strong>Aim: </strong>Functional Constipation (FC) is a common gastrointestinal disorder that imposes a considerable strain on global health. It negatively impacts the quality of life and results in significant healthcare expenditures. Current treatments, such as lifestyle changes and medications, fail to meet patient satisfaction due to efficacy and safety issues. Electroacupuncture (EA), with its precise stimulation control and standardized protocols, shows promise in FC management. However, optimal EA parameters for FC treatment are yet to be established. Our study reviews EA applications in FC to inform a standardized treatment approach and explore EA's therapeutic mechanisms.</p><p><strong>Methods: </strong>This comprehensive study utilized research literature from databases including PubMed, Embase, OVID, Web of Science, the Cochrane Library, CNKI, VIP, and Wanfang to perform a descriptive analysis of acupoint selection and EA parameters. It proceeded to analyze high-frequency acupoint groupings and stimulus parameters, followed by the excavation and analysis of core acupoint prescriptions. Subsequent steps integrated potential target identification for these core formulas, the assembly of a \"core acupoint-prescription-target-constipation\" network, and the construction of a protein-protein interaction (PPI) network to extract central targets. Additionally, Gene Ontology (GO) and KEGG enrichment analyses were conducted to prognosticate the underlying mechanisms by which EA may exert its therapeutic effects on FC.</p><p><strong>Results: </strong>In our study, we analyzed 141EA prescriptions for FC and identified a core set of acupoints including Tianshu (ST25), Fujie (SP14), Shangjuxu (ST37), and Zusanli (ST36) through data mining. The frequency of use was highest for Tianshu (ST25) with 119 occurrences, followed by Fujie (SP14) with 59, Shangjuxu (ST37) with 42, and Zusanli (ST36) with 23. PPI network analysis revealed key targets such as NFKB1, IL6, MyD88, TLR4, TNF, TLR2, and IL1B. GO and KEGG analyses of 49 constipation-associated targets identified 257 BP, 37 CC, and 41 MF terms, and 154 significant pathways, with the top 20 visualized for further analysis.</p><p><strong>Conclusion: </strong>The core acupoint prescription of EA for FC can exert its therapeutic effects by acting on multiple targets and pathways synergistically especially on NFKB1, IL6, MyD88, TLR4, TNF, TLR2, and IL1B. The research findings have preliminarily validated the fundamental effects and related mechanisms of EA parameters and core prescriptions, providing direction for further in-depth exploration of the mechanisms of action.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1482066"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red cell distribution width to albumin ratio is associated with asthma risk: a population-based study.","authors":"Jinzhen Ding, Yixiang Zhang, Xiaoyang Chen","doi":"10.3389/fmed.2024.1493463","DOIUrl":"10.3389/fmed.2024.1493463","url":null,"abstract":"<p><strong>Background: </strong>The red cell distribution width to albumin ratio (RAR), a newly identified biomarker of inflammation, has been linked to a variety of inflammatory diseases. Asthma, a major burden on global health, is an inflammatory airway disease that is profoundly affected by inflammation. This study primarily sought to examine the influence of RAR on the risk of developing asthma.</p><p><strong>Methods: </strong>Data from 1999 to 2020 was gathered from the NHANES database. The impact of RAR on asthma risk and their non-linear relationship were clarified by multivariate logit and restricted cubic spline (RCS) analyses. Subgroup and interaction analyses collectively formed the sensitivity analysis for this study.</p><p><strong>Results: </strong>This study was based on an analysis of 54,161 individuals. RAR has been identified as an independent risk factor for asthma, according to logit analysis. The moderate and high RAR groups had a 16% [95% confidence interval (CI): 1.06-1.27] and 43% (95% CI: 1.30-1.58) higher risk, respectively, compared to the lowest group. Every 0.5 unit increase in RAR almost doubled the risk of asthma [odds ratio (OR): 1.82, 95% CI: 1.55-2.12]. There was no non-linear relationship between RAR and asthma risk, based on RCS analysis. Combining subgroup and interaction analyses results, all subgroups in this study showed consistent trends with the overall population.</p><p><strong>Conclusion: </strong>Notably, this article, the first to examine the relationship between RAR and asthma risk, unveiled a positive linear correlation between them. With an increase in RAR, whether analyzed as a categorical or continuous variable, asthma risk significantly increases. This finding was beneficial for clinicians to anticipate and assess the onset of asthma through stratified or dynamic management. Given RAR's numerous advantages, its application in clinical settings held considerable promise.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1493463"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Predictive and diagnostic approaches for systemic disorders using ocular assessment.","authors":"Kai Jin, Jiong Zhang, Andrzej Grzybowski","doi":"10.3389/fmed.2024.1529861","DOIUrl":"10.3389/fmed.2024.1529861","url":null,"abstract":"","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1529861"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}