Frontiers in Medicine最新文献

{"title":"Correction: Phage derived lytic peptides, a secret weapon against <i>Acinetobacter baumannii</i>-An <i>in silico</i> approach.","authors":"Abhishek Nandy, Ruchi Yadav, Aditi Singh","doi":"10.3389/fmed.2025.1642178","DOIUrl":"https://doi.org/10.3389/fmed.2025.1642178","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmed.2022.1047752.].</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1642178"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic profiling of burn patients reveals key lactylation-related genes and their molecular mechanisms.","authors":"Yang Li, Jizhong Ma, Yeping Wang, Weibin Zhan, Qian Wang","doi":"10.3389/fmed.2025.1554791","DOIUrl":"10.3389/fmed.2025.1554791","url":null,"abstract":"<p><strong>Introduction: </strong>Burn injury is a global health concern characterized by complex pathophysiological changes. Understanding gene expression changes and molecular pathways, especially those related to lactylation, is crucial for developing effective treatments. This study aimed to analyze the transcriptomic profiles of burn patients and identify lactylation-related genes as potential biomarkers or therapeutic targets.</p><p><strong>Methods: </strong>Peripheral blood transcriptome data of burn patients and controls were obtained from the GEO database. After preprocessing to remove batch effects and normalize the data, differential genes were screened. Functional enrichment, lactylation gene analysis, machine learning for key gene selection, immune cell infiltration analysis, gene correlation and GSEA analysis, patient clustering, and upstream regulatory factor prediction were performed using various R packages. Statistical analysis was conducted using R software, with a <i>p</i>-value of < 0.05 considered significant.</p><p><strong>Results: </strong>Pathway enrichment analysis in burn patients showed significant alterations in immune-related pathways. Lactylation genes were differentially expressed, with changes in RNA processing and cell interactions. Machine learning identified four key lactylation-related molecules (RPL14, SET, ENO1, and PPP1CC). Immune microenvironment analysis revealed correlations with immune cell infiltration. Clustering analysis based on these four molecules divided burn patients into two subgroups, each exhibiting distinct gene expression patterns and pathway enrichments.</p><p><strong>Conclusion: </strong>This study provides insights into the molecular alterations in burn patients, especially regarding lactylation. The identified key molecules and pathways offer potential targets for personalized treatment. Future research should validate these findings and explore their clinical applications for improving burn patient management and prognosis.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1554791"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impacts of ageing-related changes on prehospital trauma care for older adults: challenges and future directions.","authors":"Naif Harthi, Steve Goodacre, Fiona C Sampson","doi":"10.3389/fmed.2025.1588927","DOIUrl":"10.3389/fmed.2025.1588927","url":null,"abstract":"<p><p>The ageing global population presents growing challenges for prehospital trauma care, particularly in addressing the complex needs of older adults. This narrative review explores the impacts of ageing-related anatomical and physiological changes on trauma care in the prehospital setting, with a focus on the challenges they pose for paramedic assessment, triage, and decision-making. These changes affecting the nervous, cardiovascular, respiratory, musculoskeletal, and renal systems that reduce physiological resilience and increase vulnerability to trauma, especially when compounded by frailty, polypharmacy, and comorbidities. The review highlights significant limitations in current trauma triage tools, which often lack sensitivity for identifying serious injuries in older adults and fail to incorporate frailty assessments. Although some protocols, such as the Ohio Trauma Triage Protocol, include geriatric adaptations, traditional tools continue to underperform, contributing to undertriage and suboptimal outcomes. Validated frailty assessment tools, including the Clinical Frailty Scale (CFS), Programme on Research for Integrating Services for the Maintenance of Autonomy (PRISMA-7), and Identification of Seniors at Risk (ISAR), offer promising potential for improving triage accuracy but are not yet routinely used in prehospital practice. Key gaps identified include insufficient paramedic education on ageing-related conditions, limited awareness of age-specific clinical presentations, and a lack of training in applying geriatric assessment tools. To address these issues, the review recommends integrating frailty screening into EMS triage, enhancing geriatric-specific training, and raising paramedic awareness of the physiological and clinical implications of ageing. Future research should investigate paramedics' behaviours, decision-making processes, and the feasibility of implementing frailty-based triage in the field. These strategies are essential to advancing prehospital trauma care and improving outcomes for the growing population of older trauma patients.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1588927"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward improving retention in HIV care after pregnancy: lessons from a post-pandemic cohort in the United States.","authors":"Alexandra H Latham, Andrea Lugo Morales, Elizabeth Barba Gutierrez, Michael Jochum, Sarah Conrad, Eva H Clark, Kassandra Goytia, Megan Alam, Jessica Gerard, Jennifer McKinney","doi":"10.3389/fmed.2025.1561490","DOIUrl":"10.3389/fmed.2025.1561490","url":null,"abstract":"<p><strong>Introduction: </strong>People living with HIV (PLWH) often experience low rates of retention in HIV care (RIC) and suboptimal viral suppression postpartum. Understanding contemporary barriers to RIC is crucial to identify risk factors for loss to care and thereby improve support during this vulnerable transition. This work aimed to identify factors associated with adequate RIC, defined as two HIV care visits ≥90 days apart in the first year postpartum.</p><p><strong>Methods: </strong>Electronic records were retrospectively reviewed for PLWH who delivered from 2019 to 2023 and received prenatal care within a single county health system. Variables were collected related to both maternal and neonatal HIV and obstetric or pediatric care. Variables were analyzed using descriptive statistics, and Kaplan-Meier curves were used to assess viral suppression during pregnancy and the first year postpartum. A Random Forest machine learning model was used to determine variables of relative importance for prediction of adequate RIC. Multivariable logistic regression was used to evaluate impact of identified variables on RIC.</p><p><strong>Results: </strong>Of 182 pregnancies, sixty individuals (33%) achieved adequate postpartum RIC. Adequate RIC correlated with year of delivery (<i>p</i> = 0.018), attending at least two obstetrical postpartum visits (<i>p</i> = 0.025), viral suppression at initial prenatal visit (<i>p</i> = 0.030), and shorter duration between pregnancy visit and HIV care visits before and after pregnancy (<i>p</i> < 0.001). Viral suppression was generally excellent at time of delivery (99.4%). However, viral loads rebounded after delivery, with 66.8% suppressed at 12 months postpartum. Random Forest modeling identified several clinical and social factors with relative importance for prediction of RIC. Multivariable logistic regression supported above findings with significant decreased odds of adequate RIC based on year of delivery [2021 aOR 0.306 (0.097-0.956), 2022 0.146 (0.046-0.458), 2023 0.071 (0.011-0.455)], higher viral load at initial prenatal visit [aOR 0.038 (0.002-0.889)], and longer duration between last HIV care visit and first pregnancy visit [aOR 0.419 (0.176-0.998)].</p><p><strong>Discussion: </strong>Postpartum RIC was suboptimal in this contemporary US single-site cohort. Engagement in prenatal and postpartum obstetric care predicted improved postpartum RIC. Further qualitative research is essential to improve deeper understanding of patterns of engagement perinatally in order to develop effective interventions to improve support for individuals during this difficult transition.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1561490"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated NLR and PCT levels and reduced GCS score predict 90-day mortality in heatstroke: findings from a 13-year retrospective cohort study.","authors":"Huili Guo, Jingjing Ji, Leifang Ouyang, Conglin Wang, Jinxin Jia, Zhifeng Liu","doi":"10.3389/fmed.2025.1599592","DOIUrl":"10.3389/fmed.2025.1599592","url":null,"abstract":"<p><strong>Background and objective: </strong>Heatstroke is the most severe heat-related illness and is associated with high mortality rate. Inflammation and immune dysfunction are considered the key pathophysiological processes of heatstroke. The neutrophil-to-lymphocyte ratio (NLR) can reflect the states of innate and adaptive immune systems. The aim of the present study was to explore the predictive role of the NLR in heatstroke patients.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included all patients with exertional-heatstroke (EHS) admitted to the intensive-care-unit (ICU) of the General Hospital of Southern Theater Command of PLA from June 2009 to May 2022. The dynamic changes in the main immune cell counts and ratios were recorded.</p><p><strong>Results: </strong>A total of 232 patients were enrolled. Survivors had decreased NLRs 24 h after admission, while nonsurvivors had continuously increased NLRs after admission. The AUC for the 24-h NLR was 0.928, with a cutoff of 11.981. The patients were divided into NLR-high (NLR > 11) and NLR-low (NLR ≤ 11) groups based on their 24-h NLRs. Patients in the NLR-high group had increased 90-day mortality. According to the multivariate analysis, an increased PCT level and decreased GCS score were independent risk factors for death in heatstroke patients with an NLR over 11, with odds ratios of 1.0999 (95% CI: 1.0050-1.2038, <i>p</i> value: 0.03863) and 0.6836 (95% CI: 0.5246-0.8908, <i>p</i> value: 0.00486), respectively.</p><p><strong>Conclusion: </strong>An NLR greater than 11 in the early phase could be an independent predictor of prognosis in heatstroke patients, and an increased PCT level and decreased GCS score were risk factors for a poor prognosis.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1599592"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive model for CRT risk in cancer patients with central venous access devices: a systematic review and meta-analysis.","authors":"Wenjuan Yang, Meng Fang, Kangqin Cai, Qin Pan, Cheng Zhang, Jiquan Zhang","doi":"10.3389/fmed.2025.1580920","DOIUrl":"10.3389/fmed.2025.1580920","url":null,"abstract":"<p><strong>Introduction: </strong>With the high incidence of central venous access device catheter-related thrombosis (CRT) in patients with cancer, its early onset, and the characteristics of clinically insignificant symptoms, risk assessment is essential for the targeted application of thromboprophylaxis. The aim of this paper was to review the risk prediction models developed for central venous access device CRT in patients with cancer and to evaluate their performance.</p><p><strong>Methods: </strong>PubMed, Embase, Web of Science, Cochrane Library, CNKI, SinoMed, Wanfang Data, and VIP databases were searched, and the search timeframes ranged from the establishment of the database to May 22, 2024. Two researchers independently performed literature screenings, data extractions, and quality assessments. The risk of bias and applicability of the included studies were assessed using the Predictive Model Risk of Bias Assessment Tool. A meta-analysis of the areas under the curve (AUC) values for model validation was performed using Stata 17.0 software.</p><p><strong>Results: </strong>Nineteen papers with 29 predictive models were included in this systematic review, reporting AUC values of 0.470-1.000. The incidence of central venous access device CRT in cancer patients ranges from 2.02 to 39.4%. The most commonly used predictors are D-dimer levels, BMI, and diabetes. All studies were judged to have a high risk of bias, mainly due to poor reporting of the areas analyzed. The combined AUC value of the six validated models was 0.81 (95% confidence interval: 0.76-0.86), indicating good model discrimination.</p><p><strong>Discussion: </strong>Most available CRT prediction models exhibited moderate-to-good predictive performance. However, all the studies were rated as having a high risk of bias according to the PROBAST scale. Future studies should adhere to methodological and reporting guidelines for large-sample, multi-center external validation of models, focusing on studies that report rigorous design and optimization or on the development of new models.</p><p><strong>Systematic review registration: </strong>PROSPERO, identifier: CRD42024516563.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1580920"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Omalizumab-associated hair loss: a case of eyebrow alopecia areata, literature review and FAERS database analysis.","authors":"Qian Wang, Hua Lei, Ge Yang, Ying Li, Wei Liu, Lixia Zhang, Xiyuan Zhou","doi":"10.3389/fmed.2025.1605826","DOIUrl":"10.3389/fmed.2025.1605826","url":null,"abstract":"<p><p>Hair loss is a rare adverse reaction associated with omalizumab, with limited literature reports. The incidence, underlying mechanisms, and clinical characteristics of omalizumab-associated hair loss have not been clarified. We report a 52-year-old female with chronic spontaneous urticaria (CSU) who developed significant loss of eyebrows after 12 weeks of omalizumab treatment at 300 mg per 4 weeks. The diagnosis of alopecia areata (AA) was confirmed through dermoscopic examination and clinical manifestation. While maintaining omalizumab treatment for CSU, topical 0.03% tacrolimus ointment was initiated for treatment of AA. Regrowth of eyebrows was observed at 28 weeks of omalizumab treatment. We then performed a literature review, analyzing eight patients from five articles and one conference abstract, and concurrently analyzed data from 756 cases reported in the FDA adverse event reporting system (FAERS) database of patients developing alopecia after omalizumab use. Our findings suggest that omalizumab may induce alopecia, particularly among females and individuals aged 18-60 years. However, establishing a direct cause-effect relationship between alopecia and the drug remains challenging. AA may be the more uncommon type of omalizumab-associated hair loss, though it may be a transient phenomenon. Even if the incidence of this adverse effect is low, it warrants the clinician's attention. Improved recognition of omalizumab-associated hair loss can optimize pretreatment preparation and patient counseling.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1605826"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of pharmacotherapy for primary sclerosing cholangitis.","authors":"Hang Yang, Juan Zhen, Xiaoyan Huang, Minqi Chen, Hongsi Cui, Xia Sheng, Xinyu Li","doi":"10.3389/fmed.2025.1544601","DOIUrl":"10.3389/fmed.2025.1544601","url":null,"abstract":"<p><p>Primary sclerosing cholangitis (PSC) represents a cholestatic disease hallmarked by persistent and progressive inflammation of the bile ducts. Despite its low incidence and unfavorable prognosis, there is no pharmacological therapy capable of altering the course of PSC, and liver transplantation is the only effective treatment. In the face of the landscape of PSC, pharmaceutical therapy encounters great challenges that demand expeditious resolution. However, at present, many drugs have been carried out to phase III clinical trials and are expected to be applied to the clinical treatment of PSC patients in the future. This review integrates relevant research findings from PubMed and Web of Science databases up to October 2024 over the past decade, excluding other liver diseases, such as fatty liver disease, viral hepatitis, and alcoholic liver disease. It covers the vast majority of drugs currently in clinical trials, and focus on the summary of hot research drugs, and summarizes the latest drug-based therapeutic for PSC. This review not only provides certain information for clinical research and treatment of PSC, but it is also the first time that stem cell therapy has been linked to PSC, which is expected to improve cholestasis and liver inflammation in patients with PSC. The article provides explanations and comparisons of different drugs, offering a basis for future researchers to choose medications.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1544601"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices of pharmacists on hierarchical management of COPD: a cross-sectional study in Jiangsu Province.","authors":"Qiuhui Wu, Yanhong Meng, Ruobin Zhang, Yuhang Ding, Yongsheng Wang, Jinping Zhang","doi":"10.3389/fmed.2025.1616768","DOIUrl":"10.3389/fmed.2025.1616768","url":null,"abstract":"<p><strong>Purpose: </strong>This study assessed pharmacists' knowledge, attitudes, and practices regarding hierarchical management of COPD patients, examining influencing factors to inform standardization.</p><p><strong>Patients and methods: </strong>A cross-sectional survey was conducted from December 2022 to March 2023 using convenience sampling, yielding 206 valid responses via WeChat-distributed questionnaires. Data analysis employed t-tests, ANOVA, and multiple linear regression.</p><p><strong>Results: </strong>Pharmacists' mean scores were: knowledge (6.13 ± 1.96), attitudes (27.56 ± 3.37), and practices (21.02 ± 6.06). Regression analysis highlighted correlations between knowledge scores and gender, education, and hospital level (<i>p</i> < 0.05); attitudes and academic qualifications (<i>p</i> < 0.05); practices and hospital level (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Pharmacists demonstrated moderate knowledge, positive attitudes, and average practices in COPD management. Tailored training programs addressing educational and institutional disparities are essential to enhance their capacity in hierarchical COPD care.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1616768"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-surgical treatment of strabismus in children: a review of recent advances.","authors":"Shulan Huang, Xuemei Zhong, Chanjuan Quan, Mingwen Zhang","doi":"10.3389/fmed.2025.1582284","DOIUrl":"10.3389/fmed.2025.1582284","url":null,"abstract":"<p><p>Pediatric strabismus is a progressive condition that, in the early stages, presents as either esotropia or intermittent or constant exotropia when both eyes focus on the same target. If not promptly addressed, the child's ocular accommodative convergence and fusion abilities will gradually weaken, ultimately affecting visual function and causing various inconveniences in daily life and learning. For children with mild strabismus, those who are young, have poor cooperation, or are awaiting surgery for a long time, non-surgical treatment is a good option. It offers high safety, ease of use, and has certain effects in alleviating strabismus symptoms and improving visual function. However, there are multiple non-surgical treatment options, and currently, clinical practice lacks clear consensus on which approach is best. The choice and implementation of treatment methods still need to be determined based on the specific situation, such as the child's age and type of strabismus. In recent years, with the deepening of ophthalmological research, non-surgical treatment methods have been enriched, including a combination of visual training, occlusion therapy, and corrective glasses, which have shown certain clinical effects. This article will review the non-surgical treatment options for pediatric strabismus, explore current research progress, and discuss future development directions.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1582284"},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}