Frontiers in Medicine最新文献

{"title":"Postoperative sepsis-associated neurocognitive disorder: mechanisms, predictive strategies, and treatment approaches.","authors":"Zijing Gao, Zhenyu Xu","doi":"10.3389/fmed.2025.1513833","DOIUrl":"10.3389/fmed.2025.1513833","url":null,"abstract":"<p><p>Sepsis is a critical condition characterized by an abnormal immune response to infection, resulting in systemic inflammation, organ failure, and high mortality rate. Postoperative sepsis, accounting for nearly one-third of all sepsis cases, predominantly affects the elderly and individuals with pre-existing conditions, with fatality rates between 30 and 50%. Surgical stress induces immune, hormonal, and metabolic disturbances, heightening susceptibility to immune dysregulation and sepsis. Neurocognitive disorders related to postoperative sepsis, which share pathophysiological similarities with sepsis-associated encephalopathy, involve neuroinflammation, blood-brain barrier disruption, and mitochondrial dysfunction. Cognitive impairments, such as delirium, are frequent postoperative complications that vary in severity depending on the surgical complexity. This review examined the underlying mechanisms of these dysfunctions, the influence of different surgical procedures, and predictive and therapeutic strategies, including machine learning models, aimed at improving patient outcomes.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1513833"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between physical activity and lung function in adolescents: a cross-sectional NHANES study.","authors":"Xiaoyuan Chen, Jinhai Ma, Linghua Dong, Yan Chen, Keke Chen","doi":"10.3389/fmed.2025.1538221","DOIUrl":"10.3389/fmed.2025.1538221","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the relationship between physical activity (PA) and lung function in adolescents using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2012. While physical activity is known to improve respiratory health, its impact on specific lung function parameters in adolescents, particularly across different activity intensities, remains underexplored.</p><p><strong>Methods: </strong>We analyzed the effects of varying intensities of PA on lung function parameters-specifically Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 s (FEV₁), and Forced Expiratory Flow (FEF)-in a sample of 896 adolescents aged 12-19 years. Linear regression analyses were employed to examine the relationship between PA duration and lung function, adjusting for potential confounders. The sample was stratified by intensity of PA (low, moderate, and high) to assess differential impacts on lung function.</p><p><strong>Results: </strong>The analysis revealed significant improvements in lung function with increased PA duration, with high-intensity PA showing the most pronounced effects. Specifically, high-intensity PA was associated with a 2.0 (95% CI: 0.43, 3.5) increase in FVC and a 2.0 (95% CI: 0.74, 3.4) increase in FEV₁ per unit increase in activity. Moderate-intensity PA also demonstrated significant improvements in lung function, though to a lesser extent. Stratified analyses identified significant associations within certain racial subgroups, with Mexican American and Other Hispanic adolescents more likely to maintain normal lung function.</p><p><strong>Conclusion: </strong>These findings highlight the importance of regular physical activity, particularly high-intensity exercise, in enhancing lung function during adolescence. The results emphasize the need for targeted public health interventions to encourage PA, especially in racially diverse populations. Further longitudinal studies are needed to evaluate the long-term effects of PA on lung health and to establish causal relationships.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1538221"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming dental education: interactive and student-centered learning with team-based learning in the undergraduate program.","authors":"Teun J de Vries, Katie L Crouwel, Erica Vogelzang, A Isa Levert, Egbert Neels, Amber de Wilde, Pepijn Koopman, Denise E van Diermen, Geerling E J Langenbach, E Etienne Verheijck","doi":"10.3389/fmed.2025.1579237","DOIUrl":"10.3389/fmed.2025.1579237","url":null,"abstract":"<p><p>World-wide, educational curricula have made a transition toward (inter)active student-centered learning and teaching. To incorporate consistency within a curricular reform, it is important to make choices that are applied to all courses. Here we describe the implementation of team-based learning (TBL), an effective educational approach for activated learning at a dental school. TBL stimulates students to participate actively in their own learning process. This team-oriented method fosters problem solving, critical academic reasoning, clinical decision-making and communication skills among students, already early in their educational career. In the first year of the undergraduate program, TBL was introduced as a mandatory component, constituting 10% of the teaching activities and overall grade. To facilitate this transition, a dedicated team of teachers and educationalists (the TBL team) was formed to prepare the transition. The initial step involved establishing a TBL course and conducting training sessions for faculty to familiarize them with this new teaching methodology. Teachers received constructive feed-back on their own TBL application session. Due to the Covid-19 pandemic, TBL was introduced as an online variant, requiring close collaboration with IT-services. Halfway through the academic year, the implementation was evaluated through separate panel discussions with students and teachers separately. Overall, TBL was perceived favorably by both staff and students. Students appreciated the team work and noted that TBL added value to their learning process. This was also the outcome of the end of the academic years' student survey on TBL, where especially questions on collaborative teamwork scored 4.22 on average on a 1-5 Likert's Scale. TBL was inspiring for teachers, the student teams of TBL provided a safe environment for students to voice their thoughts. The activating nature of TBL was recognized as beneficial, though it requires continuous effort and motivation from instructors. Coaching and guiding were perceived as highly effective instructional methods. Some teachers acknowledged the challenge of transitioning from a traditional \"one-person\" show approach to a more collaborative teaching style. Both evaluations facilitated further refinement of the TBL approach. Particularly, during the social intercourse-deprived Covid-19 era, the fixed-groups format of TBL helped students to experience a sense of belonging.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1579237"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Episiotomy and perineal trauma during childbirth in primiparous women: associations with anxiety, quality of life, vaginal and sexual symptoms in the first year postpartum.","authors":"Maria Patricia Roman, Răzvan Ciortea, Stergios K Doumouchtsis, Andrei Mihai Măluţan, Carmen Elena Bucuri, Oana Mihaela Oltean, Cristina Mihaela Ormindean, Viorela Elena Suciu, Ionel Daniel Nati, Denisa Rus, Dan Mihu","doi":"10.3389/fmed.2025.1510417","DOIUrl":"10.3389/fmed.2025.1510417","url":null,"abstract":"<p><strong>Introduction: </strong>Childbirth-related pelvic floor trauma is prevalent among primiparous women and can lead to significant physical and psychological consequences. While the impact of pelvic floor trauma on physical outcomes has been studied, the relationship between anxiety caused by such trauma and long-term patient-reported outcomes (PROs) such as vaginal symptoms, sexual function, and quality of life (QoL) remains underexplored. This study aims to fill this gap by investigating the association between anxiety induced by pelvic floor trauma during childbirth and these key PROs.</p><p><strong>Methods: </strong>This prospective longitudinal cohort study analyzed data from 175 nulliparous women who delivered at term a singleton fetus in cephalic presentation and sustained some form of perineal trauma. Anxiety levels were assessed at two time points: during labor and at 12 months postpartum, using a single-item 10-point Likert scale. The other PROs were measured using the International Consultation on Incontinence Questionnaire-Vaginal Symptoms tool (ICIQ-VS).</p><p><strong>Results: </strong>Findings revealed that higher anxiety scores at birth were associated with elevated anxiety levels at 12 months postpartum and correlated significantly with increased vaginal symptoms, sexual symptoms, and QoL. Notably, while anxiety was linked to negative physical outcomes, higher anxiety scores were also associated with improved perceived QoL, suggesting the potential role of coping mechanisms in response to childbirth trauma as well as the need for future studies using more specialized anxiety tools.</p><p><strong>Conclusion: </strong>The study underscores the intricate relationship between psychological distress and physical health outcomes in postpartum women. Addressing both anxiety and physical symptoms through personalized care strategies may enhance recovery and overall wellbeing. Future research should explore effective interventions to mitigate anxiety, evaluate resilience and improve PROs in this population.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1510417"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between fecal incontinence and asthma among adult Americans: evidence from NHANES 2005-2010.","authors":"Na Wang, Yongfu Song, Xiaofei Xie, Zhuang Wang, Yongji Wang","doi":"10.3389/fmed.2025.1564308","DOIUrl":"10.3389/fmed.2025.1564308","url":null,"abstract":"<p><strong>Objectives: </strong>There is a paucity of research exploring the relationship between fecal incontinence (FI) and asthma. This study seeks to evaluate the potential correlation between FI and asthma among adult Americans.</p><p><strong>Methods: </strong>Utilizing a cross-sectional design, this study comprised a sample of 11,128 adults aged 20 years and older sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010. FI is characterized by the involuntary excretion of solid, liquid, or mucus stool occurring at least once a month. Adjusted odds ratios (OR) were calculated using logistic regression models. Subgroup analyses were performed to validate the robustness of the findings.</p><p><strong>Results: </strong>After adjusting for baseline characteristics, lifestyle habits, and comorbidities, a significant association was observed between FI and an increased risk of asthma (OR: 1.33, 95% CI: 1.1-1.61, <i>P</i> = 0.003). Subgroup analysis revealed a significant correlation between FI in females and asthma (OR: 1.36, 95% CI: 1.06-1.73), and this correlation is particularly pronounced in middle-aged and elderly individuals, further supporting the association between FI and asthma.</p><p><strong>Conclusion: </strong>We found a significant positive correlation between FI and asthma. Females and individuals aged over 45 demonstrate an increased vulnerability to developing asthma. Prompt intervention for individuals experiencing fecal incontinence may mitigate the risk of asthma onset.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1564308"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell sequencing reveals cellular differences and potential mechanisms in congenital pulmonary airway malformation.","authors":"Jinxi Huang, Qiang Chen, Songming Hong, Junjie Hong, Hua Cao","doi":"10.3389/fmed.2025.1548177","DOIUrl":"10.3389/fmed.2025.1548177","url":null,"abstract":"<p><strong>Objectives: </strong>Congenital pulmonary airway malformation (CPAM) is a common fetal lung developmental abnormality whose pathological process is not fully understood.</p><p><strong>Method: </strong>Single-cell sequencing technology is a novel high-throughput method that can reveal differences between different cell types and their role in disease.</p><p><strong>Results: </strong>By analyzing single-cell sequencing data from CPAM lesion tissue and normal tissue, we found an increase in erythrocytes, plasma cells and mast cells in CPAM samples. Additionally, genes such as CCL5, NKG7, GZMB, and SCGB1A1 were highly expressed in CPAM lesion tissues. The differentially expressed genes in CPAM samples are mainly related to functions such as inflammatory response, tissue remodeling, and immune response. Moreover, analysis of the signaling pathways involved in these differentially expressed genes revealed that pathways such as lysosome, phagosome, adherens junction, focal adhesion, and protein processing in the endoplasmic reticulum may be associated with the pathological process of CPAM.</p><p><strong>Conclusion: </strong>This study provides an in-depth analysis of the cellular differences between CPAM tissues and normal tissues using single-cell sequencing technology, revealing key cell types and functions involved in the development of CPAM. These findings provide important clues for a better understanding of the pathological process of CPAM and serve as a basis for identifying potential therapeutic targets.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1548177"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-infiltrating lymphocytes are the key determinants of pathological features associated with pathogenic <i>BRCA</i> variants in high-grade serous ovarian carcinoma.","authors":"Dang H Nguyen-Phan, Tin Dang, Anh N Dang, Loc T H Huynh, Phuong T B Nguyen, Vu Q Tran, Hanh T T Ngo, Thao T P Doan, Tu A Thai, Chien-Chin Chen","doi":"10.3389/fmed.2025.1555883","DOIUrl":"10.3389/fmed.2025.1555883","url":null,"abstract":"<p><strong>Background: </strong>High-grade serous ovarian carcinoma (HGSOC), an aggressive cancer associated with pathogenic <i>BRCA</i> variants, causes genomic instability and sensitivity to poly (ADP-ribose) polymerase inhibitors. Identifying pathogenic <i>BRCA</i> variants is crucial for the treatment of HGSOC; however, genetic testing is expensive and time-consuming. This study aimed to explore pathological features, particularly the presence of tumor-infiltrating lymphocytes (TILs), as potential surrogates to streamline patient selection for genetic testing.</p><p><strong>Methods: </strong>We retrospectively analyzed 58 cases of HGSOC with known <i>BRCA</i> variant profiles. Tumors were categorized as TIL-positive or TIL-negative based on the presence of > 40 or ≤ 40 intraepithelial lymphocytes in a single high-power field (HPF), respectively. Key pathological features, including solid, endometrioid, and transitional (SET) architecture patterns; necrosis; and mitotic activity, were evaluated within these subgroups. Statistical analyses were used to determine the associations between these features and <i>BRCA</i> variant status.</p><p><strong>Results: </strong>In TIL-negative HGSOCs, SET patterns were strongly associated with pathogenic or likely pathogenic <i>BRCA</i> variants (<i>p</i> = 0.028), emerging as the most reliable morphological marker in this group. In TIL-positive HGSOCs, low mitotic activity (≤7 mitotic figure per 10 HPFs) was significantly correlated with pathogenic <i>BRCA</i> variants (<i>p</i> = 0.0002), underscoring its diagnostic significance. Necrosis and mitotic activity in TIL-negative cases and SET patterns in TIL-positive cases were not significantly associated with pathogenic <i>BRCA</i> variants. Combined analysis of both TIL subgroups diluted these associations, underscoring the significance of stratifying cases by the immune context.</p><p><strong>Discussion: </strong>The presence of TILs affects the diagnostic value of pathological features for <i>BRCA</i> variant status in HGSOC. Regarding pathogenic <i>BRCA</i> variants, SET patterns and low mitotic activity were identified as critical markers in TIL-negative tumors and TIL-positive tumors, respectively. These associations likely stem from interactions among genomic instability, immune response, and tumor growth. Our framework leverages these insights to prioritize high-risk cases for genetic testing, thereby optimizing resource allocation.</p><p><strong>Conclusion: </strong>The presence of TILs is critical for understanding the association between pathological features and pathogenic <i>BRCA</i> variants in HGSOC. To improve pathogenic <i>BRCA</i> variant prediction, optimize genetic testing, and guide tailored intervention, our framework integrates immune context and morphological markers. This approach is especially useful in resource-limited settings and can enhance diagnostic efficiency and clinical decision-making.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1555883"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers of traumatic brain injury: narrative review and future prospects in neurointensive care.","authors":"Marta Pryzmont, Urszula Kosciuczuk, Mateusz Maciejczyk","doi":"10.3389/fmed.2025.1539159","DOIUrl":"10.3389/fmed.2025.1539159","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a significant medical problem because of its high early mortality rate in intensive care and high risk of severe neurological complications in long-term follow-ups. Craniocerebral injuries are one of the most important issues in intensive therapy due to the limited prognostic possibilities for the neurological consequences of such injuries. Computed tomography and magnetic resonance imaging are the most common and available radiological tools for presenting and describing morphological brain damage in the acute and chronic phases of TBI. The use of biomarkers may improve the accuracy of establishing the severity and prognoses in patients with severe traumatic brain damage. Based on the available publications, there is no definitive and accurate single marker that has high prognostic value regarding neurological brain tissue damage; however, the combination of several biomolecules (i.e., biomarkers of neuronal, astrocyte, and cytoskeleton disruption and chemokines) significantly increases the diagnostic value. Most scientific studies are based on serum and cerebrospinal fluid assays. This publication presents the current state of the knowledge about the markers of nervous tissue damage in the brain and their clinical utility in mortality prediction and neurological prognosis in critical neurointensive care. Moreover, this review article presents the correlations between the biomarkers, radiological signs of brain injury, and clinical scales, as well as the latest scientific and publication trends, such as microRNA genetic studies and different laboratory assay methodologies using various biological materials.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1539159"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiotherapy-induced changes in corneal morphology and biomechanics in myopathic thyroid eye disease.","authors":"Pengsen Wu, Jing Rao, Shenglan Yang, Xiaohan He, Yuqing Wu, Guiqin Liu","doi":"10.3389/fmed.2025.1612518","DOIUrl":"10.3389/fmed.2025.1612518","url":null,"abstract":"<p><strong>Purpose: </strong>To assess differences in corneal morphology and biomechanics between patients with myopathic thyroid eye disease (TED) and normal controls (NCs), as well as to evaluate these changes following radiotherapy.</p><p><strong>Methods: </strong>Patients with active myopathic TED and age-, sex-, and spherical equivalent-matched NCs were enrolled in this study. All patients underwent radiotherapy and were followed up for 6 months post-treatment. Complete ophthalmic examinations were conducted for all subjects. Corneal morphology was evaluated using Pentacam, and biomechanics were assessed with Corvis ST tonometry, both before and 6 months post-radiotherapy.</p><p><strong>Results: </strong>This prospective, comparative clinical study involved 50 eyes from 50 TED patients and 30 eyes from 30 NCs. Post-radiotherapy, the intraocular pressure (IOP), proptosis, disease activity, diplopia, eye motility restriction and muscular index in TED patients significantly improved. Corneal morphological parameters such as elevation deviation, including back elevation (Db), pachymetric progression, relational thickness, overall deviation, and the index of surface variance, were significantly greater in TED patients compared to NCs, while Ambrosio's Relational Thickness maximum was significantly lower. After radiotherapy, Db decreased, and posterior surface astigmatism increased with statistical significance. Significant biomechanical changes were observed in patients with TED after adjustment with biomechanically corrected IOP, including reduced A2 time and peak distance, increased tomographic and biomechanical index (TBI), as well as diminished maximum whole eye movement length (WEML). Post-radiotherapy, a significant increase in WEML was observed. Correlation analysis suggested that improvements in ocular biomechanics may be linked to reductions in IOP and proptosis.</p><p><strong>Conclusion: </strong>Patients with myopathic TED demonstrated observable corneal alterations, including increased steepness, surface irregularity, reduced corneal hysteresis, and decreased orbital compliance. These biomechanical changes were associated with elevated TBI values, indicating heightened susceptibility to corneal ectatic disorders. Ocular biomechanical parameters may serve as as potential quantitative biomarkers for assessing treatment effectiveness in TED management.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1612518"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does construction of the healthcare data center affect the health of older adults?evidence from China.","authors":"Yao Yao, Pengyu Xu","doi":"10.3389/fmed.2025.1589319","DOIUrl":"10.3389/fmed.2025.1589319","url":null,"abstract":"<p><strong>Background: </strong>The construction of the National Healthcare Data Center (NHDC) has driven data aggregation and interoperability, and created the conditions necessary for older adults to improve their health through digital health management. This study aimed to evaluate the effect of healthcare data center construction on improving the health of the older adults and elaborate on the role of health management within the underlying mechanism.</p><p><strong>Methods: </strong>The difference-in-differences (DID) model was used as an empirical strategy for causal identification. It included baseline regressions, robustness checks, heterogeneity analysis and mechanism analysis.</p><p><strong>Results: </strong>The NHDC construction significantly improves health of older adults, which is reflected in higher subjective health ratings, reduced prevalence of chronic diseases and multimorbidity, enhanced physical function, and improved mental health. Heterogeneity analysis indicates that the effect is more significant among rural residents, individuals under 60 years of age, and male seniors. Increased active health management efforts by the older adults, along with a higher likelihood of receiving health management services, play a significant role in the channels of effect.</p><p><strong>Conclusion: </strong>The construction of the healthcare data center characterized by driving data aggregation and interoperability improves the health of older adults by promoting their digital health management.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1589319"},"PeriodicalIF":3.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}