Frontiers in Medicine最新文献

{"title":"Impact of hand grip strength reduce on health related quality of life in patients with transfusion-dependent thalassemia insights from the SF-36 survey: a cross-sectional analysis.","authors":"Mustafa Duran, Nermin Keni Begendi, Sinan Kazan, Hamza Sümter, Nigar Abdullayeva, Yusuf Ulusoy, Mehmet Enes Süzek, Nur Akad Soyer","doi":"10.3389/fmed.2025.1657096","DOIUrl":"10.3389/fmed.2025.1657096","url":null,"abstract":"<p><strong>Purpose: </strong>Thalassemias negatively impact health-related quality of life (HQoL) due to chronic anemia and complications from regular transfusions. This study aimed to investigate the effects of hand grip strength loss on QoL in patients with transfusion-dependent thalassemia (TDT) via the Short Form-36 (SF-36) health survey.</p><p><strong>Patients and methods: </strong>A cross-sectional study included 47 patients with transfusion-dependent thalassemia (TDT) and a group of healthy controls. Hand grip strength was assessed via a digital handgrip dynamometer. HQoL was evaluated through the SF-36 survey, which includes physical and mental health subdomains. Correlations between dominant arm strength and SF-36 subdomain scores were analyzed.</p><p><strong>Results: </strong>Compared with healthy controls, TDT patients presented significantly lower dominant arm muscle strength (<i>p</i> < 0.001). Ferritin levels were elevated (<i>p</i> < 0.001), indicating iron overload and chronic anemia. The physical functioning (<i>p</i> < 0.001) and physical role difficulty (<i>p</i> = 0.002) scores were significantly lower in the TDT group. Handgrip strength was positively correlated with the physical functioning subdomain of SF-36 (<i>p</i> = 0.005, <i>r</i> = 0.402), while vitality (<i>p</i> = 0.009, <i>r</i> = 0.379) and mental health (<i>p</i> = 0.016, <i>r</i> = 0.349) were also associated with overall quality of life scores. No significant correlations were found for emotional or physical role difficulties.</p><p><strong>Conclusion: </strong>In patients with TDT, reduced handgrip strength was significantly associated with lower health-related quality of life. These findings suggest that handgrip strength may serve as a simple, non-invasive marker of overall well-being in this population. Addressing muscle strength alongside conventional management may help improve both physical and psychosocial outcomes in TDT patients.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1657096"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial aspects of rosacea: patient-reported coping strategies in Saudi Arabia.","authors":"Faten Albukhari, Kayan Alotaibi, Ebtesam Almajed, Wijdan A AlMutiri, Nuwayyir Abdullah Alqasimi, Nouf Abdullah Alzahrani, Hayat Alzahrani","doi":"10.3389/fmed.2025.1634437","DOIUrl":"10.3389/fmed.2025.1634437","url":null,"abstract":"<p><strong>Background: </strong>Rosacea is a chronic inflammatory skin condition that negatively impacts patients' psychological well-being. Coping strategies can influence disease adaptation and psychosocial outcomes. However, little is known about how rosacea patients in Saudi Arabia cope with the burden of this disease.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using a structured tool that combined clinical assessments with the Arabic version of the Brief COPE. Participants were recruited through dermatology clinics and online platforms. Coping strategies were categorized into three domains: problem-focused, emotion-focused, and avoidant. Statistical analyses included correlation tests and post-hoc clustering.</p><p><strong>Results: </strong>176 participants (mean age: 28.8 ± 8.25 years; 79.5% female) completed the survey. Problem-focused coping had the highest mean score (68.48), followed by emotion-focused (60.98) and avoidant strategy (49.01). Maladaptive strategies, such as substance use and behavioral disengagement, were the least adopted. Significant positive correlations were observed between disease duration and all three coping styles, with the strongest correlation found for the emotional-focused coping strategy (r = 0.323, <i>p</i> < 0.001). Higher rosacea severity was positively associated with a longer disease duration (r = 0.317, <i>p</i> < 0.001). Higher education as well as employment status were correlated with greater use of adaptive strategies, while students scored the lowest across all domains.</p><p><strong>Conclusion: </strong>Rosacea patients in Saudi Arabia predominantly use constructive, culturally grounded coping strategies, with religion playing a crucial role. Sociodemographic factors such as education and employment significantly influence coping profiles. In light of these findings, it is essential to develop culturally sensitive interventions that promote adaptive coping and integrate social and spiritual support.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1634437"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient safety attitudes and their predictors among emergency healthcare providers in a military medical city in the Kingdom of Saudi Arabia: a cross-sectional study.","authors":"Adel Saeed S Alotaibi, Salem Ali S Alshehri, Naif H Alanazi, Abdualrahman S Alshehry, Homood A Alharbi, Abdulmajeed Wadid A Alanazi, Ali Ahmed M Alkhalaf, Gerlynn C Tumala, Abdulaziz Moadi B Alotaibi, Mohammed Ahmed Alfaifi, Regie B Tumala","doi":"10.3389/fmed.2025.1541273","DOIUrl":"10.3389/fmed.2025.1541273","url":null,"abstract":"<p><strong>Background: </strong>The increase in the number of patient safety incidents poses a challenge for hospital management. Various studies have been conducted on the safety of patients in healthcare settings, but gaps exist concerning the attitude of healthcare providers (HCPs) toward the safety of patients, including those in the emergency department (ED) in Saudi Arabian hospitals.</p><p><strong>Aim: </strong>This study aimed to determine the attitude of HCPs toward patient safety in the ED at Prince Sultan Military Medical City (PSMMC) and to identify demographic factors predictive of HCPs' attitude.</p><p><strong>Methods: </strong>A descriptive-correlational design was used. The study was conducted on a convenience sample of 202 HCPs working in the ED at PSMMC. Data were collected in December of 2022 and analyzed using SPSS v.23. Multiple linear regression analyses were performed separately for the six domains and overall patient safety attitude as dependent variables. For the seven models, the demographic variables were considered predictor variables.</p><p><strong>Results: </strong>Overall, HCPs demonstrated a positive attitude toward patient safety (Mean = 3.75/5). Among the six domains, job satisfaction scored highest (Mean = 3.96), while stress recognition scored lowest (Mean = 3.54). However, the respondents reported some patient safety issues and agreed on the difficulty in speaking up if they perceived a problem with patient care, as well as in discussing errors. Significant relationships and predictors were established in all six dimensions and in the overall patient safety attitude. The study findings revealed that three demographic variables, namely, certification in ED (<i>p</i> = 0.044), value of patient safety (<i>p</i> = 0.001), and profession (<i>p</i> = 0.014), demonstrated significant correlations with the overall attitude toward patient safety. Furthermore, years of experience as an HCP in ED (<i>p</i> = 0.019), value of patient safety (<i>p</i> = 0.004), and profession (<i>p</i> = 0.047) were identified as predictors of the overall patient safety attitude.</p><p><strong>Conclusion: </strong>The overall attitude of HCPs toward patient safety in the ED at PSMMC was found to be positive across all six domains and overall. Several demographic factors were identified as significantly influencing their positive attitudes toward patient safety. However, some patient safety issues still need to be resolved, needing interventional and strategic solutions from hospital administration. These solutions should take into account, and give high consideration to, the significant demographic factors identified as predictors of HCPs' attitudes toward patient safety.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1541273"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of the effects of long-term oxygen therapy combined with exercise rehabilitation on exercise capacity, cardiopulmonary function, and quality of life in patients with COPD.","authors":"Qi Muge, Suriguga, Yuqing, Aronggaowa, Taojin, Lanying Chen","doi":"10.3389/fmed.2025.1640084","DOIUrl":"10.3389/fmed.2025.1640084","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of long-term oxygen therapy (LTOT) combined with exercise rehabilitation vs. exercise rehabilitation alone in improving exercise capacity, cardiopulmonary function, and quality of life in chronic obstructive pulmonary disease (COPD) patients.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in the Chinese Biomedical Literature Database (CBM), Wanfang, China National Knowledge Infrastructure (CNKI), Cochrane Library, EMBASE, ScienceDirect, and PubMed for studies published from January 2010 to the present. Controlled clinical trials comparing oxygen therapy and/or exercise rehabilitation in COPD patients were included. Two independent reviewers extracted data and assessed risk of bias using the Cochrane Handbook (version 5.3). Meta-analysis was performed using RevMan 5.3.</p><p><strong>Results: </strong>Nine studies (<i>N</i> = 703) met inclusion criteria. Compared with the control group (CG), the combined LTOT and exercise group showed significant improvements in 6-min walk distance (6MWD), forced expiratory volume in 1 s (FEV1), and FEV1/FVC ratio (<i>P</i> < 0.05). PaO₂ levels tended to be higher but showed substantial heterogeneity. No significant differences were observed in blood oxygen saturation, heart rate, or PaCO₂. Quality of life significantly improved in the combined therapy group.</p><p><strong>Conclusion: </strong>LTOT combined with exercise rehabilitation is more effective than exercise alone in improving exercise capacity, pulmonary function, and quality of life in COPD patients. However, cardiac benefits remain unclear, warranting further studies.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1640084"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canonical correlation analysis on the association between pulmonary function and obesity in early-onset COPD: CT-based body composition analysis.","authors":"Jiaru Shi, Tianye Li, Zhenghao Chen, Luoman Su, Qiongyan Wu, Hongjun Zhao, Chengshui Chen","doi":"10.3389/fmed.2025.1633451","DOIUrl":"10.3389/fmed.2025.1633451","url":null,"abstract":"<p><strong>Background: </strong>While body composition impacts pulmonary function, the differential effects of visceral (VAT) vs. subcutaneous adipose tissue (SAT) in early-onset COPD remain unquantified.</p><p><strong>Objective: </strong>To elucidate the relationship between obesity patterns and pulmonary function in early-onset COPD versus non-COPD populations, focusing on body mass index (BMI), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) distribution.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 290 patients (144 early-onset COPD, 146 non-COPD) aged 20-50 years. Body composition (BMI, SAT, VAT) was quantified via CT at the L1 vertebral level. Pulmonary function was assessed by bronchodilator responsiveness testing (FEV₁/FVC, MEF₇₅, MEF₅₀, MEF₂₅). Canonical correlation analysis (CCA) was used to evaluate the multidimensional associations between body composition and pulmonary function.</p><p><strong>Results: </strong>Canonical correlation analysis revealed distinct multidimensional relationships between body composition and pulmonary function across study cohorts (<i>p</i> < 0.05). In the early-onset COPD cohort (N = 144), a statistically significant canonical variate (r = 0.383, <i>λ</i> = 0.172) demonstrated moderate association strength linking body composition (X₁: BMI, SAT, VAT) with pulmonary function (Y₁: FEV₁, FVC, MEF₇₅, MEF₂₅). Conversely, the non-COPD group (N = 146) exhibited stronger canonical correlation (r = 0.537, <i>λ</i> = 0.405), with body composition (X₂: BMI, VAT) associating with pulmonary function (Y₂: FEV₁, FVC).</p><p><strong>Conclusion: </strong>In summary, early-onset COPD patients with elevated BMI and VAT but reduced SAT exhibited improved pulmonary function across most parameters. This enhancement was not observed in MEF₅₀ and MEF₂₅. In contrast, the non-COPD cohort exhibits overall respiratory enhancement, as the cross-loading coefficient of MEF25-an indicator reflecting the weight of a variable in contributing to the canonical variate-is extremely small (0.05) and has a negligible impact on the overall association.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1633451"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The impact of primary care on cancer screening program performance: strategies to increase uptake and effectiveness.","authors":"Cecilia Acuti Martellucci, Enrique Quintero, Christos Lionis","doi":"10.3389/fmed.2025.1696813","DOIUrl":"10.3389/fmed.2025.1696813","url":null,"abstract":"","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1696813"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclobenzaprine-related adverse events: a comprehensive pharmacovigilance analysis using the FDA Adverse Event Reporting System.","authors":"Jiakuan Tu, Chaoxiang Zhang, Shuihua Xie, Jianhua He, Hao Zhang","doi":"10.3389/fmed.2025.1574395","DOIUrl":"10.3389/fmed.2025.1574395","url":null,"abstract":"<p><strong>Background: </strong>Cyclobenzaprine, a centrally-acting muscle relaxant, is widely used for the treatment of musculoskeletal pain. Despite its efficacy, concerns regarding its safety profile, particularly adverse events (AEs), have been increasingly reported. This study aims to comprehensively analyze cyclobenzaprine-related AEs using the FDA Adverse Event Reporting System (FAERS) database to identify potential safety signals and inform clinical practice.</p><p><strong>Methods: </strong>A retrospective pharmacovigilance study was conducted using FAERS data from Q1 2004 to Q3 2024. Reports involving cyclobenzaprine as the primary suspect drug were analyzed. Descriptive statistics and disproportionality analyzes, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multinomial Gamma Poisson Shrinkage (MGPS), were employed to detect safety signals. Subgroup analyzes were performed to explore demographic heterogeneity. Furthermore, the Weibull distribution was utilized to construct a model for the risk of adverse events as time progresses.</p><p><strong>Results: </strong>Out of 18,289,374 AE reports, 2,425 were linked to cyclobenzaprine. Employing four distinct computational approaches at the preferred term (PT) level, we pinpointed 1,100 PTs signifying remarkable adverse reactions. The adverse reactions listed on the drug's label, like cardiac arrest, respiratory arrest, drug hypersensitivity, dizziness, and somnolence, presented conspicuous signals. In addition, we discovered potential adverse reactions not detailed on the label, for example, toxicity to various agents, completed suicide, drug abuse, overdose, drug interaction, and confusional state. Subgroup analysis brought to light gender-specific AEs. Males had a higher likelihood of experiencing delirium and hallucinations, whereas females were more inclined to encounter drug hypersensitivity and muscle spasms. The vast majority of these AEs were reported during the first month of cyclobenzaprine treatment, with a median onset time of 7 days.</p><p><strong>Conclusion: </strong>This study confirms known AEs associated with cyclobenzaprine and identifies new potential risks, such as toxicity and suicidal behavior. These findings underscore the need for enhanced monitoring and further research to mitigate risks, particularly in vulnerable populations. Clinicians should remain vigilant for both somatic and psychiatric AEs when prescribing cyclobenzaprine, especially in patients with a history of mental health issues or substance abuse.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1574395"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative analysis by targeted metabolomics revealed the regulatory function of donkey oil on skin metabolites.","authors":"Min Li, Jinni Sun, Guangyuan Liu, Zhijie Chen, Tao Wu, Hang Tie, Cong Wang","doi":"10.3389/fmed.2025.1684399","DOIUrl":"10.3389/fmed.2025.1684399","url":null,"abstract":"<p><strong>Background: </strong>Donkey oil, an edible oil rich in unsaturated fatty acids and vitamin E, has the potential to become a multifunctional ingredient for skincare. However, its molecular mechanisms in maintaining skin health remain unknown.</p><p><strong>Methods: </strong>In this study, 64 volunteers with either healthy or inflammatory skin were divided into two groups and applied donkey oil for 28 days. Then, we measured the targeted metabolites including 65 kinds of organic acids, 94 kinds of amino acids, and 48 kinds of free fatty acids and their derivates in the skin by comparative metabolomics analysis of two groups to assess changes before and after application.</p><p><strong>Results: </strong>We found differential levels of seven (three upregulated and four downregulated) organic acids in the healthy skin group, six (two upregulated and four downregulated) organic acids in the inflammatory skin group, and one shared organic acid (4-hydroxyphenylacetic acid) in response to donkey oil application after 28 days. Regarding amino acids and their derivatives and free fatty acids, 10 (1 upregulated and 9 downregulated) amino acids and derivatives were found in the healthy skin group, while 7 (2 upregulated and 5 downregulated) were found in the inflammatory skin group. Additionally, three shared amino acids and their derivatives (5-hydroxytryptamine, tryptophan, and 5-aminovaleric acid) were found. For free fatty acids, 10 (8 upregulated and 2 downregulated) were regulated in the healthy skin group, and 7 (1 upregulated and 6 downregulated) were regulated in the inflammatory skin group. Furthermore, six shared free fatty acids were regulated by donkey oil.</p><p><strong>Conclusion: </strong>By metabolite functional annotation, donkey oil may influence the levels of several metabolites, including 4-hydroxyphenylacetic acid, 5-hydroxytryptamine, tryptophan, 5-aminovaleric acid, decanoic acid, octanoic acid, <i>cis</i>-11,14,17-eicosatrienoic acid, myristic acid, tridecanoic acid, and pentadecanoic acid. These metabolites are mainly enriched in aromatic amino acid metabolism and fatty acid biosynthesis metabolism to facilitate the maintenance of skin homeostasis.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1684399"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modified swan incision combined with lateral rectus suspension for exotropia: a retrospective cohort study demonstrating shorter operative time and faster recovery.","authors":"Jiao Liu, Rongjie Guo, Wenhao Shen, Jiaxuan Jiang, Yiran Chu, Changyu Wu, Kai Hu","doi":"10.3389/fmed.2025.1571642","DOIUrl":"10.3389/fmed.2025.1571642","url":null,"abstract":"<p><strong>Background: </strong>A modified Swan incision (MSI) combined with lateral rectus muscle suspension surgery represents an innovative strabismus surgical technique developed by our research team. Compared to the conventional Swan incision, the MSI features a 50% reduction in length with more posterior placement. The suspension technique is a modified recession approach that corrects strabismus by creating a hammock-like structure to reposition the muscle at new insertion site, rather than directly suturing the muscle to the sclera. This study aims to evaluate the safety, efficacy, and potential advantages of this MSI technique for exotropia.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 66 patients with exotropia treated from January 2024 to December 2024. The patients were divided into two groups based on actual surgical procedures: the MSI group (33 patients, 42 eyes) and the control group (33 patients, 36 eyes). The MSI group underwent the MSI technique, while the control group underwent traditional Parks incision combined with lateral rectus recession. The surgical time, postoperative recovery, and correction outcomes were compared between the two groups.</p><p><strong>Results: </strong>The MSI group showed significantly shorter surgical time (<i>P</i> < 0.0001) and lower redness score at 1 week postoperatively (<i>P</i> < 0.001), with comparable surgical success rate to control group (<i>P</i> > 0.9999).</p><p><strong>Conclusion: </strong>The MSI combined with lateral rectus suspension surgery demonstrates both efficacy in ocular alignment correction and favorable safety in surgery. This technique significantly shortens surgical time, reduces tissue damage, improves postoperative recovery, making it a valuable option for widespread application.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1571642"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of herbal medicine on clinical characteristics and biological markers in pulmonary pure ground-glass nodules: study protocol for a multicenter randomized triple-blind controlled trial.","authors":"Shi-Yan Tan, Qiong Ma, Qian Wang, Tao-Yu Wu, Zi-Fan Wang, Zong-Yi Mao, Chong Xiao, Chuan Zheng, Feng-Ming You, Yi-Feng Ren","doi":"10.3389/fmed.2025.1663135","DOIUrl":"10.3389/fmed.2025.1663135","url":null,"abstract":"<p><strong>Background: </strong>The widespread use of chest computed tomography (CT) screening has led to more frequent detection of pure ground-glass nodules (pGGNs). A subset of pGGNs carries a potential risk of malignant transformation. However, the current management strategy for stable pGGNs predominantly involves surveillance, with a notable absence of effective intervention strategies. Traditional Chinese medicine (TCM), as an adjunctive therapy, offers considerable promise. Preclinical studies indicate that Chuanjie Granules (CJG), a TCM compound formulation, may have potential benefits in reducing the size of pGGNs. However, there is a lack of strong evidence from large-scale randomized controlled trials. Consequently, this study aims to evaluate the clinical effectiveness and safety of CJG for pGGNs through a well-designed clinical trial and explore its mechanisms of action.</p><p><strong>Methods: </strong>This study is a prospective, randomized, triple-blind, placebo-controlled, multicenter clinical trial designed to enroll 172 patients who have been radiologically diagnosed with pGGNs. Participants will be randomly allocated in a 1:1 ratio to receive either CJG or placebo, both with standard health education. The intervention lasts 3 months with participants receiving either CJG or a placebo, followed by a 1-year observational period after treatment. The primary outcome is the change in pGGN maximum diameter, while secondary outcomes include nodule reduction rate, density changes, malignancy risk, and patient-reported outcomes. The study will also use 16S rRNA gene sequencing and gas chromatography-mass spectrometry-based metabolomics to examine oral and gut microbiota and explore microbial-metabolic mechanisms.</p><p><strong>Discussion: </strong>This study aims to rigorously assess the efficacy and safety of CJG and explore its mechanism of action in the intervention of pGGNs through a randomized controlled trial. Positive outcomes are anticipated to furnish the first high-quality evidence-based medical support for the use of TCM in the early intervention of pGGNs, thereby potentially enhancing clinical decision-making processes.</p><p><strong>Clinical trial registration: </strong>http://itmctr.ccebtcm.org.cn/, identifier ITMCTR2025001413.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1663135"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}