The effect of VEGF, ET-1 and TGF-β1 levels in peritoneal dialysis effluent on peritoneal solute transport function.

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Frontiers in Medicine Pub Date : 2025-09-18 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1548218
Xinxuan Han, Long Li, Xiangjiang Yu, Yan Jiang, Feifei Li, Shixi Luo, Xingxin Zeng, Ming Zhang
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引用次数: 0

Abstract

Objective: This study aims to assess the impact of Vascular endothelial growth factor (VEGF), Endothelin-1 (ET-1), and Transforming growth factor-β1 (TGF-β1) levels in peritoneal dialysis effluent on peritoneal solute transport function.

Methods: We included 450 patients from four hospitals, spanning from January 2016 to January 2018. Patients were categorized into low-transport (D/Pcr ≤ 0.65) and high-transport groups (D/Pcr > 0.65) based on solute transport rates. We compared the effluent levels of VEGF, ET-1, and TGF-β1 between the groups, employed Pearson's correlation for analysis, and used multivariate logistic regression to identify independent factors influencing solute transport.

Results: VEGF and TGF-β1 levels were significantly higher in the high-transport group (p < 0.05), showing a positive correlation with solute transport function (r = 0.721 and 0.539 respectively, p < 0.05). ET-1 levels showed no significant difference between the groups. VEGF and TGF-β1 were identified as significant independent factors affecting solute transport (OR = 3.438 and 3.684, p < 0.05). ROC curve analysis highlighted the predictive value of VEGF and TGF-β1 for solute transport function. Kaplan-Meier and COX regression analyses indicated that high transport was associated with lower survival rates, with VEGF and TGF-β1 serving as independent risk factors for mortality (RR = 3.442 and 3.550, p < 0.05).

Conclusion: VEGF and TGF-β1 levels in peritoneal dialysis effluent are strongly correlated with solute transport function and serve as significant predictors of patient outcomes.

腹膜透析出水VEGF、ET-1和TGF-β1水平对腹膜溶质转运功能的影响。
目的:探讨腹膜透析出水中血管内皮生长因子(VEGF)、内皮素-1 (ET-1)、转化生长因子-β1 (TGF-β1)水平对腹膜溶质转运功能的影响。方法:我们纳入了2016年1月至2018年1月期间来自四家医院的450例患者。根据溶质转运率将患者分为低转运组(D/Pcr ≤ 0.65)和高转运组(D/Pcr > 0.65)。比较各组流出物中VEGF、ET-1和TGF-β1的水平,采用Pearson相关分析,并采用多因素logistic回归确定影响溶质转运的独立因素。结果:高转运组VEGF、TGF-β1水平显著升高(p r = 0.721、0.539,p p p )结论:腹膜透析出水VEGF、TGF-β1水平与溶质转运功能密切相关,可作为患者预后的重要预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
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