Frontiers in Medicine最新文献

{"title":"Corrigendum: Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index.","authors":"Stephan Kemenes, Liu Chang, Maja Schlereth, Rita Noversa de Sousa, Ioanna Minopoulou, Pauline Fenzl, Giulia Corte, Melek Yalcin Mutlu, Michael Wolfgang Höner, Ioannis Sagonas, Birte Coppers, Anna-Maria Liphardt, David Simon, Arnd Kleyer, Lukas Folle, Michael Sticherling, Georg Schett, Andreas Maier, Filippo Fagni","doi":"10.3389/fmed.2025.1617441","DOIUrl":"10.3389/fmed.2025.1617441","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmed.2025.1574413.].</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1617441"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Recovery of consciousness ahead of MRI image lesion information in cerebral fat embolism syndrome.","authors":"Zhixiong Zhuang, Yan Bo, Yunpin Pan, Jianfeng Huang","doi":"10.3389/fmed.2025.1566578","DOIUrl":"10.3389/fmed.2025.1566578","url":null,"abstract":"<p><strong>Background: </strong>The absence of definitive international guidelines for the diagnosis and treatment of fat embolism syndrome (FES) has prompted clinicians to undertake independent research. The admission of a patient with suspected cerebral FES (CFES) prompted clinicians to engage in self-directed learning.</p><p><strong>Case summary: </strong>We presented a case of a 28-year-old male patient who had developed CFES as a complication of a fracture. The initial magnetic resonance imaging (MRI) scan revealed the presence of scattered, multiple punctate lesions in the majority of the cerebral white matter. Following a series of treatments, including supportive care, the final MRI scan (on the fifth day) demonstrated that the majority of lesions had either been resorbed or were undergoing resorption, with a small number of lesions demonstrating fusion and an increase in size. However, the patient's impaired consciousness was successfully restored 5 days after the onset of the disease.</p><p><strong>Conclusion: </strong>MRI findings should serve as the foundation for diagnosing CFES, rather than being used as a criterion for evaluating discharge. We proposed that MRI findings of \"star pattern\" and \"vasogenic edema\" represented the optimal imaging criteria for diagnosing CFES. The timing of the diagnosis of CFES can be utilized as a validation measure for the diagnosis of CFES, which was conducive to the early and complete recovery from consciousness disorders. Moreover, we found the lesion information from MRI images lags behind the rate of recovery in the level of consciousness. The clinician can consider that the cerebral fat embolism syndrome has reached the therapeutic expectation when the patient's level of consciousness is restored. The patient can then be asked to be followed up after discharge from the hospital, and the end point of the follow-up period can be indicated by observing the complete disappearance of the lesion information shown on MRI.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1566578"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Spinal cord abscess due to <i>Nocardia farcinica</i> presenting as longitudinally extensive transverse myelitis.","authors":"Tayoot Chengsupanimit, Amit Mahajan, Shelli Farhadian, Francisco Machiavello Roman","doi":"10.3389/fmed.2025.1613770","DOIUrl":"10.3389/fmed.2025.1613770","url":null,"abstract":"<p><p>A middle-aged man, renal transplant recipient, was admitted with lower extremity paralysis, loss of sensation and urinary retention. The initial diagnostic workup revealed extensive inflammatory spinal changes on imaging, consistent with longitudinally extensive transverse myelitis. Cerebrospinal fluid testing demonstrated neutrophilic pleocytosis; routine tests for bacterial and viral pathogens were negative. The patient received high-dose steroids for presumed autoimmune myelitis, but his condition worsened. Repeat spinal imaging revealed an intramedullary spinal cord abscess and a loculated collection in the cauda equina. <i>Nocardia farcinica</i> was isolated from spinal biopsy tissue cultures and metagenomic sequencing of cerebrospinal fluid. He received treatment with trimethoprim-sulfamethoxazole and linezolid, with subsequent improvement of the radiological abnormalities. At outpatient follow-up two months after initiating antimicrobials, the patient endorsed improved upper extremity strength, though remained paraplegic. This case report highlights the protean manifestations of central nervous system nocardiosis and the benefits of using metagenomic sequencing to diagnose complex central nervous system infections.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1613770"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the link between insulin resistance and cognitive impairment using estimated glucose disposal rate in a non-diabetic aging population: results from the CHARLS.","authors":"Bingqing Wang, Fei Xu, Minheng Zhang","doi":"10.3389/fmed.2025.1522028","DOIUrl":"10.3389/fmed.2025.1522028","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence suggests insulin resistance may contribute to neurodegeneration, yet its role in non-diabetic populations remains unclear. This study explores the relationship between estimated glucose disposal rate (eGDR), a measure of insulin sensitivity, and incident cognitive dysfunction in non-diabetic adults.</p><p><strong>Methods: </strong>Our longitudinal analysis utilized data from 5,178 CHARLS participants (age ≥ 45 years). Insulin sensitivity was quantified using eGDR, calculated from waist circumference, hypertension status, and hemoglobin A1c levels. Participants were stratified by eGDR quartiles for comparative analysis. We employed multivariable Cox models, survival curves, restricted cubic splines, and sensitivity testing to evaluate associations with cognitive outcomes.</p><p><strong>Results: </strong>Over an 8.7-year follow-up, cognitive dysfunction developed in 36.9% of participants. Analyses revealed significant metabolic-cognitive associations, with each standard deviation increase in eGDR linked to a 15.8% reduction in risk (adjusted hazard ratio [HR] = 0.792, 95% confidence interval [CI]: 0.793-0.881). Restricted cubic spline analysis identified non-linear threshold effects, with risk accelerating below certain eGDR levels (<i>P</i> < 0.05). Kaplan-Meier survival analysis demonstrated significant differences in cognitive impairment incidence across eGDR quartiles (<i>P</i> = 0.003). Additionally, both eGDR and metabolic score for insulin resistance (METS-IR) showed comparable predictive value for cognitive impairment risk, outperforming other metabolic indices, including the atherogenic index of plasma (AIP), and the triglyceride glucose index (TyG).</p><p><strong>Conclusion: </strong>These findings position eGDR as a promising biomarker for cognitive risk stratification in non-diabetic adults. However, further multi-database studies should validate these associations and explore the underlying mechanisms.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1522028"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory markers and neurovascular changes in the retina and choroid of diabetic patients without retinopathy: insights from wide-field SS-OCTA.","authors":"Qinxing Wu, Bin Zhao, Shengliang Dongye, Lu Sun, Bo An, Qian Xu","doi":"10.3389/fmed.2025.1566047","DOIUrl":"10.3389/fmed.2025.1566047","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to investigate the association between systemic inflammation markers and early neuronal and microvascular changes in the retinal and choroidal regions of patients with type 2 diabetes mellitus (T2DM) without clinical signs of diabetic retinopathy (DR), utilizing wide-field swept-source optical coherence tomography angiography (SS-OCTA).</p><p><strong>Methods: </strong>This retrospective, observational cohort study included 61 patients (119 eyes) with T2DM without clinical DR (NDR group) and 44 healthy individuals (82 eyes) as controls. All participants underwent a comprehensive ophthalmic evaluation and blood sampling for hematologic indices. Inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), were calculated. The mean thickness of the retina, choroid, and individual inner retinal layers, as well as the vessel density measurements of the superficial and deep retinal layers, and the choriocapillaris perfusion area, were recorded and analyzed from the OCTA images. Additionally, the choroidal vascularity index (CVI) was determined.</p><p><strong>Results: </strong>The NDR group demonstrated significantly higher levels of NLR, SII, and SIRI compared to the control group (<i>p</i> < 0.05). The diabetic cohort showed reduced vessel density in the deep capillary plexus (DCP) across all measured regions (<i>p</i> < 0.05). Significant but weak negative correlations were observed between inflammation markers, particularly NLR, and OCTA parameters, with a marked impact on the DCP (<i>r</i> = -0.21 to -0.32, <i>p</i> < 0.05) and CVI (<i>r</i> = -0.23 to -0.28, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The study provides new insights into the role of systemic inflammation in early structural and blood flow changes in the retina and choroid, occurring prior to the onset of DR. The findings highlight the importance of inflammation in the pathogenesis of DR, even in the absence of clinical signs, suggesting that systemic inflammatory markers may serve not only as early biomarkers of ocular changes in T2DM but also as potential early therapeutic targets to prevent or delay diabetic retinopathy.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1566047"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, clinical characteristics, and biological markers of postmenopausal osteoporosis and knee osteoarthritis in Beijing: study protocol for a cross-sectional and prospective study.","authors":"Zhenkai Lu, Wenye Feng, Yaxing Wang, Xuming Zhang, Xu Wei, Ming Chen, Shangquan Wang, Ting Cheng, Xin Cui, Yanming Xie","doi":"10.3389/fmed.2025.1582533","DOIUrl":"10.3389/fmed.2025.1582533","url":null,"abstract":"<p><strong>Background: </strong>Postmenopausal osteoporosis (PMOP) and knee osteoarthritis (KOA) are common musculoskeletal disorders that share risk factors such as aging, hormonal changes, and inflammation. PMOP often remains asymptomatic until fractures occur, while KOA leads to pain and disability. Their comorbidity remains underexplored, particularly in community settings. This study aims to investigate the prevalence, risk factors, and clinical features of PMOP-KOA comorbidity among Beijing residents aged 45-80 years, providing evidence-based recommendations for early identification, prevention, and management.</p><p><strong>Methods: </strong>Over 2 years, this study will conduct a PMOP-KOA screening and prospective follow-up in the Beijing community to investigate the incidence, risk factors, and clinical characteristics of PMOP-KOA. This study will undertake bone mineral density detection, collect biological samples, and record information via questionnaires.</p><p><strong>Discussion: </strong>The study aims to investigate the incidence, risk factors, and clinical characteristics of PMOP-KOA comorbidity and explore related traditional Chinese medicine syndromes based on large community-based samples in Beijing. Data on PMOP-KOA occurrence and associated risk factors over the 2 years follow-up will be available on the Chinese Clinical Trial Registry (ChiCTR2300073575).</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1582533"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A time-dependent predictive model for cardiocerebral vascular events in chronic hemodialysis patients: insights from a prospective study.","authors":"Haowen Zhong, Mengbi Zhang, Yingye Xie, Yuqin Qin, Na Xie, Yuqiu Ye, Heng Li, Hongquan Peng, Xun Liu, Xiaoyan Su, Shaohong Li","doi":"10.3389/fmed.2025.1481866","DOIUrl":"10.3389/fmed.2025.1481866","url":null,"abstract":"<p><strong>Context: </strong>The conventional risk factors for cardiocerebral vascular events (CVCs) in non-Hemodialysis (HD) patients cannot be directly applied to HD patients due to the unique characteristics of this population. More accurate information on the risk of progression to CVCs is needed for clinical decisions.</p><p><strong>Objective: </strong>To develop and validate time-dependent predictive models for the progression of CVCs in HD patients.</p><p><strong>Design setting and participants: </strong>Development and validation of time-dependent predictive models using demographic, clinical, and laboratory data from 3 dialysis centers between 2017 and 2021. These models were developed using time-dependent Cox proportional hazards regression and assessed for discrimination using the concordance index, goodness of fit using the Akaike information criterion and net reclassification improvement.</p><p><strong>Main outcome measures: </strong>CVCs included acute heart failure, acute hematencephalon, cardiac or brain-derived death, acute myocardial infarction, acute cerebral infarction, ischemic cardiomyopathy, unstable angina pectoris, and stable angina pectoris.</p><p><strong>Results: </strong>The development and validation cohorts included 233 and 215 patients, respectively. The most accurate model included age, sex, hemoglobin, serum albumin, serum phosphate, white blood cell count, blood flow rate and ultrafiltration volume during HD (C index, 0.704; 95% CI, 0.639-0.768 in the development cohort and 0.775; 95% CI, 0.706-0.843 in the validation cohort). In the validation cohort, this model was more accurate than a model containing variables whose <i>p</i> value in the Cox proportional hazards regression was less than 0.05 (NRI: 0.351, 95% CI: -0.115-0.565).</p><p><strong>Conclusion: </strong>A time-dependent model using routinely obtained laboratory tests can accurately predict progression to CVCs in HD patients.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1481866"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing anatomy education with virtual reality: integrating three-dimensional models for improved learning efficiency and student satisfaction.","authors":"Shuliang Niu, Jinlong Zhang, Jiang Lin, Binbin Wang, Jie Yan","doi":"10.3389/fmed.2025.1555053","DOIUrl":"10.3389/fmed.2025.1555053","url":null,"abstract":"<p><p>Traditional anatomy education, which primarily relies on two-dimensional imagery, often struggles to effectively convey the complex spatial relationships of human anatomy. Virtual reality and three-dimensional (3D) anatomy models present a promising solution to these limitations. This study investigates the impact of integrating 3D anatomy models into a blended learning framework across pre-class, in-class, and post-class phases. A total of 169 medical students from Xinjiang Medical University were divided into three groups: a control group (Class A, <i>n</i> = 57) following a traditional blended learning approach, and two experimental groups: Class B (<i>n</i> = 56), which incorporated continuous 3D model integration, and Class C (<i>n</i> = 56), which adopted a phased 3D model integration strategy. Learning outcomes and student satisfaction were assessed through formative evaluations, surveys, and statistical analyses. Our analytical framework employed dual statistical validation protocols: parametric testing via independent samples t-tests for normally distributed data and non-parametric verification through Mann-Whitney U tests for skewed distributions. Class B achieved higher scores than Class A across two assessment stages (<i>p</i> < 0.05). In pre-class evaluations, Class B (<i>n</i> = 56) scored 69.7 ± 7.5 compared to Class A's 63.8 ± 6.9 (<i>n</i> = 57). This performance gap persisted during in-class assessments, with Class B attaining 77.1 (± 8.7) against Class A's 70.8 (± 7.6). Prior to the intervention, Class C (<i>n</i> = 56) exhibited a mean score of 61.8 ± 6.1, which increased to 67.0 ± 6.7 post-intervention. The score gaps demonstrate the teaching method's effectiveness Class C demonstrated a statistically significant enhancement in pre-class assessment performance (<i>p</i> < 0.05) following the implementation of 3D anatomical modeling. However, no significant differences were observed among the groups in midterm or final exam scores (<i>p</i> > 0.05). Satisfaction scores in Class B were significantly higher than in Class A (<i>p</i> < 0.05), particularly in aspects of learning interest and teaching diversity. Class C also reported increased satisfaction in some dimensions after 3D model integration (<i>p</i> < 0.05). All survey instruments demonstrated good reliability (Cronbach's alpha > 0.7). In conclusion, while 3D anatomy models enhance student engagement, learning efficiency, and overall satisfaction, their effect on long-term retention and final exam performance remains limited. These findings underscore the need for a strategic approach to integrating 3D technologies in anatomy education to maximize their educational benefits.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1555053"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting myopia control outcomes with orthokeratology treatment in children: a retrospective analysis.","authors":"Fengjiao Wang, Wenwen Wang, Chengqiang Yin, Shiqi Yang, Xiaomin Zhan, Huan Chen, Jun Deng","doi":"10.3389/fmed.2025.1580023","DOIUrl":"10.3389/fmed.2025.1580023","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective observational cohort study aimed to analyze the factors influencing the effectiveness of orthokeratology (OrthoK) lens treatment in controlling myopia in children.</p><p><strong>Methods: </strong>Medical records of 200 children aged 8-15 years, with spherical equivalent refraction (SE) ranging from -1.00 to -6.00 diopters (D) and binocular anisometropia less than 1.00 D, were analyzed. The data included baseline age, SE, keratometry readings (Kf and Ks), corneal eccentricity, asymmetry indices, pupil size, and corneal diameter. Multivariate linear regression analysis was used to identify factors associated with axial length (AL) changes over a 1 year period. Additional analyses explored the relationship between treatment outcomes and lens centration parameters.</p><p><strong>Results: </strong>The mean axial length (AL) growth after 1 year was 0.20 ± 0.16 mm. Multivariate analysis identified baseline age (β = -0.725, <i>p</i> < 0.001) and baseline SE (β = 1.289, <i>p</i> < 0.001) as significant predictors of AL change. Subgroup analyses showed that children older than 11 years with baseline SE greater than -3.00 D exhibited the most favorable treatment outcomes. Lens decentration patterns were significantly correlated with treatment efficacy (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Orthokeratology treatment outcomes are significantly influenced by baseline age and refractive error. The findings suggest that patient age and the severity of initial myopia should be considered when predicting treatment outcomes. Further prospective studies are required to validate these findings and investigate the role of lens centration in treatment efficacy.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1580023"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas.","authors":"Zijing Zhang, Chuanbo Liu, Jinsheng Li","doi":"10.3389/fmed.2025.1565977","DOIUrl":"10.3389/fmed.2025.1565977","url":null,"abstract":"<p><p>Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly squamous cell carcinoma (SCC) in sun-exposed areas. Currently, there is no definitive cure for EV, and management remains largely supportive and symptomatic. We report a case of EV in a 38-year-old male, presenting with classical clinical features and histopathological findings, complicated by the simultaneous development of squamous cell carcinoma(SCC) and basal cell carcinoma (BCC). This case highlights the oncogenic potential of EV-associated HPV subtypes and the importance of regular dermatologic surveillance in affected individuals.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1565977"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}