Frontiers in Medicine最新文献

{"title":"Case Report: Synchronous aspirin-induced ileal ulcer and ascending colon adenocarcinoma: diagnostic challenges and pathophysiological insights from an incidental intraoperative finding.","authors":"Zejin Zhao, Yue Xiao, Hui Zhao, Jian Li, Jinlong Liu","doi":"10.3389/fmed.2025.1643706","DOIUrl":"https://doi.org/10.3389/fmed.2025.1643706","url":null,"abstract":"<p><p>Synchronous gastrointestinal lesions are rare, especially when colon cancer is complicated by non-specific ileal ulcers. This article presents the case of a 70-year-old man who was admitted to the hospital with a colonic space-occupying lesion detected during the physical examination. An unexpected intraoperative finding revealed a synchronous ileal lesion with signs suggestive of malignancy. The patient had no history of inflammatory bowel disease and was on regular low-dose aspirin (100 mg/d) for a long time. Colonoscopy showed a mass in the ascending colon, and biopsy confirmed the diagnosis of moderately differentiated carcinoma. In addition to the ascending colon tumor, an ulcer with focal necrosis and enlarged lymph nodes was observed in the ileum approximately 40 cm from the Bauhin valve, which was suspected to be malignant or heterogeneous. To ensure complete removal of the lesion, a partial resection of the right hemicolon combined with the ileum was performed, followed by bowel reconstruction using a single anastomosis technique. The right upper colon and terminal ileum were resected as a whole, measuring approximately 60 cm in length. Postoperative pathology confirmed the diagnosis of colonic adenocarcinoma (pT3N0M0) and non-specific ulceration of the ileum, while ruling out Crohn's disease, infection and other potential causes. The combination of the patient's medical history and the absence of evidence of metastasis suggests that aspirin-associated mucosal injury and distant pro-inflammatory mechanisms related to the tumor may be synergistically pathogenic. The patient's postoperative recovery was smooth, with no complications. This case emphasizes the importance of comprehensive intraoperative exploration, highlights the key role of multidisciplinary collaboration in differential diagnosis and surgical decision-making, and provides valuable insights for the individualized management of synchronous gastrointestinal lesions.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1643706"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for adverse maternal and fetal outcomes in SLE patients: a systematic review and meta-analysis.","authors":"Hang Liu, Meifei Li, Meijiao Wang, Minzhe Ren, Jiaying Fu, Ying Cai, Zhiyu Li, Ting Zhao, Jing Sun, Zhijun Xie","doi":"10.3389/fmed.2025.1573573","DOIUrl":"https://doi.org/10.3389/fmed.2025.1573573","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that increases the risk of adverse maternal and fetal outcomes in SLE pregnancies. Identifying potential risk factors can enhance preconception risk assessment for SLE pregnancies, thereby reducing the burden of pregnancy for SLE patients.</p><p><strong>Objective: </strong>The goal of this meta-analysis is to designate the risk factors for unfavorable maternal and fetal outcomes in SLE pregnancies by means of a systematic review of the literature and meta-analysis.</p><p><strong>Methods: </strong>The odds ratios (ORs) and associated 95% confidence intervals (CIs) were estimated using either a fixed-effects model or a random-effects model. The I² statistic was used to assess heterogeneity. Sensitivity analysis, Egger's test, the Newcastle-Ottawa Quality Assessment Scale (NOS), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system were also performed.</p><p><strong>Results: </strong>Eleven papers with 1,790 SLE patients who were pregnant were examined in the meta-analysis out of 2,467 citations that were screened. The meta-analysis's findings indicated that the onset of SLE is associated with an increased risk of preterm birth (OR: 2.85; 95% CI: 2.04, 3.99). Hypertension is associated with an increased risk of composite pregnancy outcomes (OR: 4.56; 95% CI: 2.42, 8.53), preterm birth (OR: 2.20; 95% CI: 1.53, 3.17) and preeclampsia (OR: 10.11; 95% CI: 1.83, 55.89). Renal involvement is associated with an increased risk of composite pregnancy outcomes (OR: 3.09; 95% CI: 1.66, 5.72) and preterm birth (OR: 1.65; 95% CI: 1.22, 2.23). Anti-dsDNA is associated with an increased risk of preterm birth (OR: 1.83; 95% CI: 1.13, 2.92) and pregnancy loss (OR: 2.64; 95% CI: 1.09, 6.40). Drug therapy is associated with a decreased risk of composite pregnancy outcomes (OR: 0.51; 95% CI: 0.31, 0.85), preterm birth (OR: 0.66; 95% CI: 0.48, 0.89) and pregnancy loss (OR: 0.42; 95% CI: 0.21, 0.84). Sensitivity analysis demonstrated how solid our results are. Egger's test revealed no discernible publication bias.</p><p><strong>Conclusion: </strong>The onset of SLE, hypertension, renal involvement, drug therapy, and serological factors have a predictive effect on the occurrence of adverse maternal and fetal outcomes in SLE pregnancies. Strengthening preconception risk assessment for SLE patients plays an important role in reducing pregnancy risks and improving the quality of life during pregnancy.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42024564190.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1573573"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the binding sites of VRT534 at Cx26 as a putative chemical chaperone for targeted treatment of hereditary hearing disorders.","authors":"Jennifer Harre, Dahua Wang, Athanasia Warnecke, Carsten Zeilinger","doi":"10.3389/fmed.2025.1607598","DOIUrl":"https://doi.org/10.3389/fmed.2025.1607598","url":null,"abstract":"<p><p>Hearing loss is the most common sensory disorder, significantly affecting the quality of life for millions of people worldwide. Chemical chaperones are emerging as a potential therapeutic option for hereditary forms of deafness associated with protein misfolding. VRT534, a chemical chaperone previously used in the treatment of cystic fibrosis, has been shown to modulate the activity of mutated forms of human connexin 26 (Cx26), a gap junction protein crucial for auditory function. However, the precise molecular mechanism of its interaction with Cx26 remains unclear. In this study, we investigated the ability of VRT534 to bind and functionally rescue mutant Cx26. Structural models of Cx26 were generated using AlphaFold3 and analyzed via Diff-Dock-L for binding prediction. Functional restoration by VRT534 was tested using an automated patch-clamp in HeLa cells expressing wild-type or mutant Cx26 (Cx26WT, Cx26L90P, Cx26F161S, and Cx26R184P). VRT534 restored channel function in Cx26L90P and Cx26R184P, but not in Cx26F161S. Docking data revealed stronger binding affinity of VRT534 to mutant variants, with putative binding sites located near the pore region. These findings provide new insight into the selective rescue of mutant Cx26 and support further development of chemical chaperones for hereditary hearing loss.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1607598"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Analysis of the efficacy of avatrombopag for the delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation for aplastic anemia.","authors":"Xinhe Zhang, Jia Feng, Zhengwei Tan, Herui Zhang, Huijin Hu, Yuechao Zhao, Dijiong Wu, Yu Zhang, Liqiang Wu, Tonglin Hu, Zhengsong Yan, Baodong Ye, Wenbin Liu","doi":"10.3389/fmed.2025.1696198","DOIUrl":"https://doi.org/10.3389/fmed.2025.1696198","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmed.2025.1626325.].</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1696198"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When neuroglial tissue wanders: a unique case report of subpleural heterotopia in a triploid foetus and review of the literature.","authors":"Viktor Procházka, Valeria Skopelidou, Patricie Delongová, Pavel Hurník, Richard Špaček, David Matura, Jan Pavlíček, Andrea Gřegořová, Jana Vaculová, Jozef Škarda","doi":"10.3389/fmed.2025.1598144","DOIUrl":"https://doi.org/10.3389/fmed.2025.1598144","url":null,"abstract":"<p><p>Heterotopic occurrence of neuroglial tissue is an exceedingly rare phenomenon with unclear pathogenesis, often presenting as lesions outside the central nervous system (CNS). We report a unique case of heterotopic neuroglial tissue identified in the thoracic cavity of a fetus aborted at 14 weeks due to a suspected Dandy-Walker malformation. The fetus exhibited neuroglial tissue growth subpleurally, alongside a suspected Dandy-Walker malformation and ventricular septal defect. While theories such as vascular embolisation, aspiration, and aberrant migration attempt to explain such occurrences, the exact etiology remains elusive. Our case suggests a potential association between triploidy and neuroglial heterotopia, supporting the aberrant migration and differentiation theory.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1598144"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes and perceptions of workplace intergenerational climate in Saudi universities: a cross-sectional study of nursing faculty and staff members.","authors":"Regie B Tumala, Abdualrahman S Alshehry, Homood A Alharbi, Isabelita N Pandaan, Irene M Roco, Ramon Perley M Pandaan, Naif H Alanazi, Abdulaziz M Alotaibi, Mohammed A Alfaifi","doi":"10.3389/fmed.2025.1568196","DOIUrl":"https://doi.org/10.3389/fmed.2025.1568196","url":null,"abstract":"<p><strong>Background: </strong>In the first quarter of the 21st century, significant transformations have occurred within the workforce. One prominent change is the emergence of multigenerational workplaces, which now encompass four distinct generations. Given the scarcity of research focusing on the generational climate within nursing academia, this study seeks to examine the intergenerational workplace environment among nursing faculty and staff members. <i>Objective:</i> To assess nursing faculty and staff members' attitudes and perceptions regarding colleagues of varying ages in their professional setting.</p><p><strong>Methods: </strong>This research employed a descriptive-correlational design. The current study employed the Workplace Intergenerational Climate Scale (WICS). Data collection was conducted from January 2024 to March 2024. All analyses were conducted utilizing SPSS version 28 statistical software.</p><p><strong>Findings: </strong>The current research indicated that nursing faculty and staff members held a modest perception of the intergenerational climate in their workplace, as evidenced by an overall mean score of 13.84 out of 20. Various demographic factors, such as ethnicity (nationality), educational level, and length of service, play a significant role in shaping these perceptions, thereby underscoring the intricate nature of intergenerational dynamics within nursing academia. This research is crucial for comprehending the dynamics of the work environment in nursing faculties across Saudi universities.</p><p><strong>Conclusion: </strong>The findings suggest that respondents held a moderately favorable view of their workplace's intergenerational environment. By shedding light on the perceptions of intergenerational climate, it paves the way for improved collaboration, enhanced retention, and greater overall job satisfaction. The results indicate a promising intergenerational climate that fosters job satisfaction and diminishes stereotypes, which is vital for cultivating a more unified and effective educational atmosphere.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1568196"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the risk factors and establishing multivariable prediction models for singleton macrosomia.","authors":"Jinying Luo, Wenyan Huang, Suping Luo, Lin Deng, Lihua Lin, Qiuping Liao, Jianying Yan, Jinfu Zhou","doi":"10.3389/fmed.2025.1590283","DOIUrl":"https://doi.org/10.3389/fmed.2025.1590283","url":null,"abstract":"<p><strong>Introduction: </strong>Fetal macrosomia is related to adverse neonatal and maternal health outcomes. Therefore, we aimed to evaluate the risk factors for macrosomia and establish multivariable prediction models to enable early identification, prevention, and mitigation of its adverse outcomes.</p><p><strong>Methods: </strong>This retrospective case-control study included 800 singleton pregnant women who delivered in 2022 at Fujian Maternity and Child Health Hospital and Quanzhou Women and Children's Hospital. They were categorized into the macrosomia [birth weight (BW) ≥ 4,000 g, <i>n</i> = 400] and non-macrosomia (BW = 2,500-3,999 g, <i>n</i> = 400) groups according to the BW of the newborns. Prediction models in singleton fetuses during mid-to-late pregnancy and before delivery were constructed.</p><p><strong>Results: </strong>Maternal height ≥ 165 cm [odds ratio (OR) = 2.303, 95% confidence interval (CI): 1.232-4.305], pre-pregnancy overweight (OR = 2.166, 95% CI: 1.119-4.195), pre-pregnancy obesity (OR = 3.189, 95% CI: 1.020-9.968), excessive gestational weight gain in the second trimester (OR = 2.083, 95% CI: 1.250-3.470), and at least two abnormal blood glucose values in the oral glucose tolerance test (OR = 5.267, 95% CI: 1.814-15.29) were identified as risk factors for macrosomia. Additionally, maternal abdominal circumference (AC) plus fundal length ≥ 140 cm (OR = 6.283, 95% CI: 3.976-9.927), fetal biparietal diameter ≥ 10 cm (OR = 3.373, 95% CI: 1.103-10.31), fetal head circumference ≥ 35 cm (OR = 3.473, 95% CI: 1.334-9.041), and fetal AC ≥ 36 cm at pre-delivery (OR = 23.46, 95% CI: 14.81-37.16) were risk factors for macrosomia.</p><p><strong>Discussion: </strong>The construction of the macrosomia prediction model in singleton fetuses during mid-to-late pregnancy and before delivery showed a strong predictive value. This study identified key high-risk factors for macrosomia during the perinatal period. The macrosomia prediction model developed here is expected to enable early identification of macrosomia, allowing for timely interventions aimed at reducing the risk of adverse perinatal outcomes.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1590283"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic performance and scenario-based screening strategy of six COPD questionnaires: a cross-sectional study with prevalence-driven robustness validation.","authors":"Qinqin Wang, Lingjun Liu, Qiao Zhang, Hong Li, Qianli Ma","doi":"10.3389/fmed.2025.1666703","DOIUrl":"https://doi.org/10.3389/fmed.2025.1666703","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic Obstructive Pulmonary Disease (COPD) imposes a high global burden. Spirometry is the diagnostic gold standard but has accessibility barriers. Screening questionnaires provide a feasible alternative.</p><p><strong>Objectives: </strong>To compare the diagnostic performance and robustness of six COPD screening questionnaires (LFQ: Lung Function Questionnaire; IPAG: International Primary Care Airways Group Questionnaire; Modified-IPAG; COPD-PS: COPD Population Screener Questionnaire; COPD-SQ: COPD Screening Questionnaire; SCSQ: The Salzburg COPD Screening Questionnaire) within a single cohort population, thereby providing evidence to support targeted screening for COPD.</p><p><strong>Methods: </strong>This cross-sectional study enrolled adults ≥40 years without prior asthma or non-COPD chronic lung diseases. Participants completed six screening questionnaires and spirometry. COPD was confirmed by pulmonologists. Receiver operating characteristic (ROC) curves were constructed for each questionnaire; sensitivity, specificity, accuracy (ACC), positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) were calculated. Dynamic variations in screening performance were simulated under different disease prevalence scenarios.</p><p><strong>Results: </strong>Modified-IPAG and LFQ showed highest sensitivity (94.78%/91.79%) and NPV (98.11%/97.45%); COPD-PS and COPD-SQ had highest specificity (79.32%/87.05%) and PPV (43.50%/43.87%). AUC ranged 0.681 (SCSQ)-0.796 (COPD-PS). Dynamic simulations revealed COPD-PS maintained stable ACC across prevalence (ΔACC = 0.06; β = -0.018; <i>P</i> = 0.114), while SQ declined with increasing prevalence (ΔACC = 0.26; β = -0.263; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>A \"Scenario-Priority\" strategy is proposed: For rule-out screening, use high-sensitivity tools (Modified-IPAG/LFQ); for high-risk identification, prioritize robust COPD-PS; in low-prevalence regions (<30%), use high-specificity SQ. This approach transcends the conventional \"tool-first\" static framework, delivering evidence-based support for precision COPD screening implementation.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1666703"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of a clinical prediction model for predicting early postpartum pelvic floor muscle weakness among primiparous women after vaginal delivery: a retrospective study.","authors":"Huan Dong, Xiaolei Chi, Ye Liu, Wenjuan Liu, Xinliang Chen, Xianjing Wang, Ping Liu","doi":"10.3389/fmed.2025.1605662","DOIUrl":"https://doi.org/10.3389/fmed.2025.1605662","url":null,"abstract":"<p><strong>Background: </strong>Pelvic floor muscle weakness (PFMW) is a significant postpartum complication linked to pelvic floor dysfunction. PFMW impairs quality of life and requires early intervention. This study aimed to develop and validate a clinical prediction model for early postpartum PFMW in primiparous women after vaginal delivery.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at a tertiary maternity hospital in Shanghai, China. Primiparous women with vaginal deliveries (July 2021-December 2023) were enrolled. Participants were assessed for PFMW using pelvic floor surface electromyography (sEMG) via the Glazer protocol at 42-90 days postpartum. Maternal and obstetric predictors were analyzed via univariable and multivariable logistic regression to construct a nomogram. Model performance was evaluated using concordance statistics (C-statistics), calibration curves, and decision curve analysis in both the training (<i>n</i> = 2,465) and validation (<i>n</i> = 1,049) cohorts. Internal validation was performed via ten-fold cross-validation.</p><p><strong>Results: </strong>Among 3,514 enrolled women, PFMW occurred in 25.55% (898/3,514), with comparable baseline characteristics between cohorts (age, pre-pregnancy BMI; <i>P</i> > 0.05). Multivariable analysis revealed five independent predictors: maternal age (OR 1.156, 95% CI 1.116-1.999), gestational weight gain (OR 1.146, 95% CI 1.116-1.178), instrumental delivery (forceps: OR 1.904, 95% CI 1.336-2.714), prolonged second stage of labor (OR 1.026, 95% CI 1.022-1.029), and infant weight (OR 1.003, 95% CI 1.002-1.003). The nomogram demonstrated strong discrimination [C-statistic: 0.866 (95% CI 0.850-0.882) in the training cohort; 0.870 (0.819-0.903) in the validation cohort] and good calibration. Decision curve analysis confirmed the clinical utility across threshold probabilities (0-0.3).</p><p><strong>Conclusion: </strong>This study established a validated nomogram integrating maternal and obstetric factors to predict early postpartum PFMW in primiparous women after vaginal delivery. This tool may aid in the early identification of high-risk individuals, enabling targeted rehabilitation to mitigate long-term pelvic floor dysfunction.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1605662"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-interactive feature embedding learning for medical image segmentation.","authors":"Yijia Huang, Yue Luo","doi":"10.3389/fmed.2025.1661984","DOIUrl":"https://doi.org/10.3389/fmed.2025.1661984","url":null,"abstract":"<p><p>Medical image segmentation task can provide the lesion object semantic information, but ignores edge texture details from the lesion region. Conversely, the medical image reconstruction task furnishes the object detailed information to facilitate the semantic segmentation through self-supervised learning. The two tasks are supplementary to each other. Therefore, we propose a multi-interactive feature embedding learning for medical image segmentation. In the medical image reconstruction task, we aim to generate the detailed feature representations containing rich textures, edges, and structures, thus bridging the low-level details lost from segmentation features. In particular, we propose an adaptive feature modulation module to efficiently aggregate foreground and background features to obtain a comprehensive feature representation. In the medical segmentation task, we propose a bi-directional fusion module fusing all important complementary information between the two tasks. Besides, we introduce a multi-branch visual mamba to capture structural information at different scales, thus enhancing model adaptation to different lesion regions. Extensive experiments on four datasets demonstrate the effectiveness of our framework.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1661984"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}