Frontiers in Medicine最新文献

{"title":"Optimizing diagnostic and management pathways for patients with eosinophilia of unknown origin: a multidisciplinary protocol for urgent and non-urgent evaluation.","authors":"Silvia Sánchez-Ramón, Gloria Candelas Rodríguez, Jesús Gimeno Hernández, María Luisa González Gutiérrez, Sissy Fiorella Medina Salazar, Manuel Méndez Bailón, Begoña Navas Elorza, Ángel Nieto Sánchez, Teresa Robledo Echarren, Santiago Rueda Esteban, Marcos Oliver Fragiel Saavedra, María Dolores Zamora Barrios, Cristina Martínez Prada, Celina Benavente Cuesta, Celia Pinedo Sierra","doi":"10.3389/fmed.2025.1544047","DOIUrl":"10.3389/fmed.2025.1544047","url":null,"abstract":"<p><strong>Introduction: </strong>Persistent eosinophilia of unknown cause is a key feature of numerous health disorders. These conditions present diagnostic and management challenges, often leading to delayed treatment, increased morbidity and mortality and unnecessary healthcare costs. A systematic approach to patient flow can streamline the process from presentation with eosinophilia to triage management, in hospital settings.</p><p><strong>Methods: </strong>A proposal of a novel patient flow pathway was developed through a collaborative effort involving 15 diverse multidisciplinary specialists in a public-funded tertiary teaching hospital located in Madrid, Spain, for managing eosinophilic diseases. This pathway focuses on early identification and expedited referral circuits in severe cases of hypereosinophilia and early screening of primary immunodeficient patients to optimize the journey from initial presentation through diagnosis and initial management.</p><p><strong>Results: </strong>The proposed patient flow model is designed to be replicable in other hospital settings. Its implementation aims to facilitate timely diagnosis and reduce the preventable morbidity, mortality, suffering and economic burden associated with complex eosinophilic conditions.</p><p><strong>Conclusion: </strong>The development and implementation of a structured patient flow pathway for eosinophilia of unknown cause in a tertiary hospital setting demonstrates a significant step toward improving patient outcomes. This model serves as a template for other healthcare institutions seeking to enhance the management and care of patients with eosinophilic diseases.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1544047"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital transformation of care for keratoconus patients: ML modeling structural outcomes of corneal collagen cross-linking.","authors":"Yauhen Statsenko, Darya Smetanina, Roman Voitetskii, Gillian Lylian Simiyu, Mikalai Pazniak, Elena Likhorad, Aleh Pazniak, Pavel Beliakouski, Dmitri Abelski, Fatima Ismail, Klaus Neidl-Van Gorkom, Milos Ljubisavljevic","doi":"10.3389/fmed.2025.1462653","DOIUrl":"10.3389/fmed.2025.1462653","url":null,"abstract":"<p><strong>Background: </strong>Structural outcomes of corneal collagen cross-linking (CXL) have not been thoroughly investigated. Clinical risk assessment would benefit from a reliable prognosis of postoperative minimal (MCT) and central corneal thickness (CCT).</p><p><strong>Objective: </strong>The objective of this study was to find a combination of diagnostic modalities and measurements that reliably reflect CXL efficiency in terms of corneal thickness.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical histories of 107 patients (131 eyes) who underwent CXL. The dataset included preoperative examinations and follow-up results, which totalled 796 observations.</p><p><strong>Results: </strong>The postoperative changes in MCT are more pronounced, clinically relevant, and meaningful than in CCT. MCT should serve as the major clinical marker of corneal thinning after CXL. The cornea's potential to recover reduces in advanced keratoconus. A polynomial curve demonstrates the natural course of corneal remodeling. It includes thinning immediately after CXL and stabilization with partial recovery of corneal thickness over time. Baseline pachymetry data can adequately reflect the outcomes. Preoperative BAD and topographic indices <i>strongly</i> correlate with the outcomes. Keratometry and refractometry data exhibit <i>moderate</i> associations with postoperative corneal thickness. The models trained on a combination of top correlating features, clinical data, and time after intervention provide the most reliable prognosis.</p><p><strong>Conclusion: </strong>Risk assessment is accurate with multimodal preoperative diagnostics. A stratification system should take into account findings in different diagnostic modalities.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1462653"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training and practice for drug inspectors in China: experiences, challenges, and developments.","authors":"Jinyao Sun, Lubo Guo, Zhixiang Shi, Fang Wu, Yongze Zhang","doi":"10.3389/fmed.2025.1571922","DOIUrl":"https://doi.org/10.3389/fmed.2025.1571922","url":null,"abstract":"<p><p>The professional level and inspection ability of drug inspectors directly determine the quality of inspection and affect drug safety. Drug inspectors need to guarantee that they can effectively perform their duties and better provide reliable supervision by receiving strict qualification authentication, systematic professional training, and standardized behavior management. This paper highlights the current situation of training and practice for drug inspectors in China, particularly the development and achievements in recent years, and examines the current challenges and opportunities facing the drug inspector training system in China and proposes some recommendations for improving the drug inspector training system, aiming to provide some insights for improving the overall quality and modernizing the inspection abilities of drug inspectors in China.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1571922"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving role of truncal fascial plane blocks in non-surgical pain therapy: a narrative review.","authors":"Yi Gu, Yifan Qin, Jin Wu","doi":"10.3389/fmed.2025.1612201","DOIUrl":"10.3389/fmed.2025.1612201","url":null,"abstract":"<p><p>Truncal fascial plane blocks (TFPBs), including erector spinae plane block (ESPB), quadratus lumborum block (QLB), transversus abdominis plane block (TAPB), and serratus anterior plane block (SAPB), are regional anesthesia techniques that achieves analgesia by injecting local anesthetics into a specific fascial planes of the trunk, which is primarily used for postoperative pain management or multimodal analgesia regimens. TFPBs reduce surgical site pain by blocking nerve conduction while decreasing reliance on systemic analgesics, such as opioids. This narrative review evaluates the analgesic efficacy and mechanisms of TFPB in non-surgical pain management, exploring their clinical value and future development prospects.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1612201"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical nursing effect of comprehensive nursing in department of respiratory medicine.","authors":"Caihong Shen, Min Zhang, Ting Yao, Hui Sun, Yantian Nie, Pengfei Song, Yuan Cheng, Lu Niu","doi":"10.3389/fmed.2025.1601061","DOIUrl":"10.3389/fmed.2025.1601061","url":null,"abstract":"<p><strong>Objective: </strong>To probe the clinical effect of comprehensive nursing in department of respiratory medicine.</p><p><strong>Methods: </strong>A total of 176 patients who were diagnosed and treated in the department of respiratory medicine from January 2020 to June 2022 were chosen. Based on the random lottery method, there were 90 cases in the observation group (OG) and 86 cases in the control group (CG). Patients in the CG adopted routine nursing services, while patients in the OG adopted comprehensive nursing program. The blood gas related index levels, nursing satisfaction, quality of life scores, nursing quality, patients' anxiety, depression and adverse events were compared between the two groups after nursing intervention.</p><p><strong>Results: </strong>The nursing efficiency of the OG was increased compared to the CG. The levels of PaO2 and PaCO2 in the OG were elevated relative to the CG (<i>p</i> < 0.05). The satisfaction of patients in the OG was enhanced in contrast to the CG (<i>p</i> < 0.05). The incidence rate was 2.22% in the OG and 8.48% in the CG. The nursing quality score of the OG was elevated in comparison with the CG (<i>p</i> < 0.05). The scores of anxiety and depression in the OG were increased compared to the CG (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The application of comprehensive nursing in the clinical nursing process of respiratory medicine department can effectively improve the patient's nursing satisfaction, reduce the incidence of adverse events, improve the quality of nursing, and control the patient's negative emotions, so that the effect of patients in clinical treatment can be improved and can be vigorously promoted.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1601061"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive multi-omics analysis of tandem duplicator phenotypes in non-small cell lung cancer.","authors":"Jie Li, Xinyan Pan, Yanting Bi, Jian Huang, Jun Peng, ChunLing Bai, Jianhong Hou, Yang Chen","doi":"10.3389/fmed.2025.1556840","DOIUrl":"10.3389/fmed.2025.1556840","url":null,"abstract":"<p><strong>Introduction: </strong>The Tandem Duplicator Phenotype (TDP) is a prominent genomic metric prevalent in non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>Multi-omics samples including DNA copy number, transcriptomics, somatic single-nucleotide variations, clinical data, and cell-line drug sensitivity from TCGA and CCLE are delved into TDP characteristics.</p><p><strong>Results: </strong>Our thorough analysis reveals that patients with smaller span sizes TDP have a more intricate genome, moderate pathology, enhanced therapeutic response, favorable prognosis, a more active immune system, and higher drug sensitivity. In contrast, those with larger span sizes TDP exhibited opposite trends.</p><p><strong>Discussion: </strong>The integrated analysis underscores that an in-depth molecular assessment of TDP can offer invaluable insights into its role in cancers. Classification strategy of TDP could recognize the chemotherapy sensitivity of different NSCLC patients.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1556840"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of 2 D strain in the detection of subtle myocardial involvement in group A and B patients with chronic obstructive pulmonary disease.","authors":"Rania Kaddoussi, Ikram Chamtouri, Wafa Dhouib, Imen Touil, Saoussen Ben Abdallah, Monia Daami, Fatma Ezzahra Elassoufi, Walid Jomaa, Wissal Rouetbi, Ahmed Turki, Khaldoun Ben Hamda","doi":"10.3389/fmed.2025.1471588","DOIUrl":"10.3389/fmed.2025.1471588","url":null,"abstract":"<p><strong>Background: </strong>Myocardial involvement mediated by chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality. Conventional transthoracic echocardiography (TTE) parameters are poor in the detection of subclinical myocardial dysfunction.</p><p><strong>Aim: </strong>To investigate the contribution of strain in the early detection of cardiac damage in clinically stable COPD patients.</p><p><strong>Methods: </strong>This was a comparative study between COPD patients (classified A or B) with normal and reduced right ventricle (RV) strain. The COPD assessment test (e.g., CAT score), spirometry [e.g., forced expiratory volume in 1 s (FEV₁, L)], 6 min walk test [e.g., 6 min walk distance (6MWD, m)], and both conventional TTE [i.e., left ventricular ejection fraction (LVEF), right atrium (RA), RV, left ventricle global longitudinal strain (LV GLS)], and strain (e.g., impaired RV strain is > -19), were performed.</p><p><strong>Results: </strong>Eighty COPD patients [mean ± standard deviation (SD): age = 66 ± 9 years, LVEF = 60.1 ± 5%, RA = 25 ± 7%, RV = -19.9 ± 3.7%, LV GLS v -21.1 ± 2, and 48% had impaired RV strain] were included. Compared to COPD patient with normal RV strain, those with reduced RV strain had (i) Lower 6MWD (310 ± 113 vs 470 ± 104 m; <i>p</i> = 0.001), (ii) Lower FEV₁ (1.63 ± 0.73 vs 2.18 ± 0.41 L; <i>p</i> = 0.012), and (iii) Higher CAT score (21 ± 10 vs 13 ± 6; <i>p</i> = 0.012). An impaired RV strain was associated with a higher risk of hospitalizations for acute exacerbation in the post inclusion year, (respectively for 55% and 25%; <i>p</i> = 0.024). No death was recorded during the study period.</p><p><strong>Conclusion: </strong>Group A and B COPD patients having normal conventional TTE parameters, speckle tracking is a key parameter in the detection of subclinical myocardial dysfunction.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1471588"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of socioeconomic status on chronic obstructive pulmonary disease prognosis: a national cohort study.","authors":"Hyewon Lee, Jiyun Jung, Hee-Young Yoon","doi":"10.3389/fmed.2025.1584945","DOIUrl":"10.3389/fmed.2025.1584945","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a major cause of global morbidity and mortality, with socioeconomic status (SES) playing a significant role in disease outcomes. While the impact of individual SES on COPD has been reported, the influence of both individual and neighborhood SES on clinical outcomes remains unclear. We aimed to evaluate the association between SES and COPD outcomes.</p><p><strong>Method: </strong>We conducted a retrospective cohort study using 2015-2018 data from the Korean National Health Insurance Service-National Sample Cohort, linked with census data. SES was assessed at both individual (income, insurance type) and neighborhood levels (residential area, elderly proportion, education level, gross regional domestic product, and total population density). Outcomes included overall mortality and hospitalization, which were evaluated using Cox proportional hazard models adjusted for demographic and air pollution.</p><p><strong>Results: </strong>Among 12,820 patients (mean age 63.5 years, 47.2% male), higher income was significantly associated with lower mortality risk (hazard ratio [HR] = 0.961, 95% confidence interval [CI] = 0.936-0.986) in the adjusted model. Suburban residence was associated with increased mortality risk (HR = 1.432, 95% CI = 1.089-1.884), while rural residence was not significant after adjustment. For hospitalization, higher income was also significantly associated with a lower risk (HR = 0.987, 95% CI = 0.979-0.995). Suburban (HR = 1.097, 95% CI = 1.013-1.187) and rural (HR = 1.138, 95% CI = 1.046-1.239) residence also remained significantly associated with increased hospitalization risk in the adjusted models. Additionally, a higher proportion of older adults (HR = 1.010, 95% CI = 1.004-1.016) and lower educational attainment (HR = 0.992, 95% CI = 0.989-0.995) were also significantly associated with hospitalization risk.</p><p><strong>Conclusion: </strong>These findings suggest that individual SES is associated with both mortality and hospitalization among patients with COPD, while neighborhood SES influences hospitalization but not mortality after adjustment.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1584945"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of bilberry extract combined with docosahexaenoic acid on the expression of Chrnb4 gene in the sclera of myopic guinea pigs.","authors":"Mei-Hong Zhu, Qian Wen, Tai-Nan Lin, Yun Gao, Xiao-Ting Liu, Jing-Hua Lin, Miao Lin, Qiao-Mei Shi","doi":"10.3389/fmed.2025.1590362","DOIUrl":"10.3389/fmed.2025.1590362","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the therapeutic potential of bilberry extract combined with docosahexaenoic acid (DHA) in myopia management by examining their effects on Chrnb4 gene expression in the sclera of lens-induced myopic guinea pigs and elucidating the underlying regulatory mechanisms, thereby providing a theoretical foundation for the development of natural active component-based myopia prevention and treatment strategies.</p><p><strong>Methods: </strong>One hundred twenty guinea pigs were systematically allocated into five experimental groups: normal control (NC), lens-induced myopia (LIM), LIM+DHA, LIM+bilberry extract (LIM+BE), and LIM+DHA+BE. Myopia was experimentally induced through the application of -6.0D lenses. The intervention groups received daily administrations of DHA (100 mg/kg), bilberry extract (16.5 mg/kg), or their combination for a duration of 12 weeks. Ocular parameters including refractive status and axial length were quantified using a handheld refractometer and A-scan ultrasound, respectively. Choroidal thickness (ChT) and choroidal vascularity index (CVI) were evaluated through swept-source OCT imaging. Molecular analyses encompassing Chrnb4 expression, dopamine concentrations, and TGF-β/MMP-2/TIMP-1 pathway components were conducted using immunofluorescence, ELISA, and Western blot techniques.</p><p><strong>Results: </strong>Following 4 weeks of myopia induction, the LIM group demonstrated significant myopic changes, including reduced refraction (-3.75 ± 1.35 D), decreased ChT (89.00 ± 10.37 μm), increased axial length (11.33 ± 1.67 mm), and diminished CVI (22.64 ± 4.91%) compared to NC group (all <i>P</i> < 0.001). After 12 weeks of therapeutic intervention, the combined treatment group showed marked improvements in ocular parameters, with refraction measuring -2.46 ± 0.92 D and axial length reduced to 9.94 ± 1.10 mm. Notably, ChT and CVI increased by 8.7 and 15.6%, respectively, compared to the LIM group (<i>P</i> < 0.05). Molecular analysis revealed significant upregulation of Chrnb4 protein expression, elevation of dopamine levels to 41.13 ± 1.58 nmol/g, suppression of TGF-β and MMP-2 expression, and enhancement of TIMP-1 levels (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The combination of bilberry extract and DHA demonstrates significant efficacy in controlling myopia progression through multiple mechanisms, including upregulation of Chrnb4 gene expression, modulation of the TGF-β/MMP-2/TIMP-1 signaling pathway, and enhancement of dopamine levels. These findings collectively contribute to the inhibition of scleral remodeling and axial elongation. This study provides valuable insights for the development of novel, multi-targeted natural therapeutic approaches for myopia prevention and treatment.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1590362"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of elevated tumor markers in patients with biliary pancreatitis.","authors":"He Han, Zhiyuan Li, Yunfan Li, Liwen Zhang, Jixiang Chen, Xin Fan","doi":"10.3389/fmed.2025.1486963","DOIUrl":"10.3389/fmed.2025.1486963","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the clinical significance of elevated tumor markers in patients with biliary pancreatitis. It aims to develop a machine learning-based clinical prediction model to facilitate early intervention and improve outcomes in acute biliary pancreatitis (ABP).</p><p><strong>Methods: </strong>We collected data from patients admitted with biliary pancreatitis to the Department of General Surgery at Jiangsu University Hospital from January 1, 2016, to December 31, 2023. We recorded general patient information.</p><p><strong>Results: </strong>Markers including Carbohydrate Antigen (CA) 50, CA19-9, CA125, CA724, CA242, ferritin, leukocyte count, high-sensitivity C-reactive protein (HS-CRP), total bilirubin, direct bilirubin, alanine aminotransferase, and aspartate aminotransferase were significantly higher in the severe acute pancreatitis (SAP) and moderately severe acute pancreatitis (MSAP) groups compared to the mild acute pancreatitis (MAP) group (<i>P</i> < 0.05). Univariate logistic regression analysis identified white blood cell count, HS-CRP, CA50, CA19-9, CA125, urinary amylase, total bilirubin, aspartate aminotransferase, and hospitalization duration as risk factors for progression to MSAP or SAP. Multivariate logistic regression analysis confirmed hospitalization duration as an independent risk factor.</p><p><strong>Conclusion: </strong>Elevated tumor markers have clinical significance in biliary pancreatitis. We propose a clinical prediction model based on machine learning to screen variables and guide treatment adjustments for MAP.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1486963"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}