Frontiers in Medicine最新文献

{"title":"Misdiagnosis of occult heterotopic intramural ectopic pregnancy by two-dimensional ultrasound: Two case reports.","authors":"Jian Zhang, Zeyang Dong, Shaofeng Guo, Hongxia Ma, Bin Huang","doi":"10.3389/fmed.2025.1620400","DOIUrl":"https://doi.org/10.3389/fmed.2025.1620400","url":null,"abstract":"<p><p>We report two cases of heterotopic intramural ectopic pregnancy (HIMP) following multiple abortions, with lesions located near the uterine fundus or uterine horn. These cases are particularly challenging to diagnose using early two-dimensional transvaginal sonography (TVS). We analyzed multimodal imaging in combination with transabdominal ultrasound (TAS), color Doppler flow imaging (CDFI), three-dimensional TVS, and magnetic resonance imaging (MRI) for early diagnosis and ultimately removed the gestational sac tissue via hysteroscopy. The combination of multimodal imaging techniques, serum <i>β</i>-human chorionic gonadotropin (β-hCG) levels, and clinical vigilance should be considered to prevent the catastrophic consequences of HIMP, particularly when conventional two-dimensional TVS results are equivocal or misleading.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1620400"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal prehabilitation is an effective strategy to reduce postoperative complications and improve physical function and anxiety in patients with colorectal cancer undergoing elective surgery: a systematic review and network meta-analysis.","authors":"Na Li, Xiaoli Liu, Yanping Wang, Ruimei Song, Xufeng Xie","doi":"10.3389/fmed.2025.1619959","DOIUrl":"https://doi.org/10.3389/fmed.2025.1619959","url":null,"abstract":"<p><strong>Background: </strong>Preoperative prehabilitation represents a viable approach to improve postoperative recovery and quality of life in colorectal cancer (CRC) patients, though debates persist regarding the efficacy of specific prehabilitation modalities.</p><p><strong>Objective: </strong>This study aims to compare and rank prehabilitation strategies for enhancing postoperative outcomes in CRC patients through a network meta-analysis, identifying the optimal preoperative prehabilitation method.</p><p><strong>Methods: </strong>We included randomized controlled trials (RCTs) assessing four prehabilitation strategies in CRC patients. Outcome measures focused on postoperative complications, hospital stay duration, 6-min walk test, and states of anxiety and depression. The effect sizes for dichotomous outcomes were measured by odds ratios (OR), and for continuous outcomes by mean differences (MD) or standardized mean differences (SMD), with 95% credible intervals (CrIs).</p><p><strong>Results: </strong>Our analysis included 27 RCTs involving 2,946 CRC patients. NMA results indicated that, compared to the control group (CON), only the multimodal (Mul) approach significantly reduced postoperative complications (OR: 0.47, 95%CrI: 0.26-0.85) and hospitalization time (MD: -1.17, 95CrI: -1.77 to -0.57). Moreover, Mul was the only strategy that improved pre-surgical 6-min walk test results (MD: 27.22, 95CrI: 12.71-41.73) and anxiety levels (SMD: -0.69, 95CrI: -1.34 to -0.04), with sustained improvements in the 6-min walk test observed up to 4 weeks post-surgery (MD: 19.22, 95CrI: 5.94-32.50).</p><p><strong>Conclusion: </strong>The Mul prehabilitation program is the effective strategy for improving surgical outcomes in CRC patients. This comprehensive approach not only aids in reducing postoperative complications and shortening hospital stays but also enhances physical and psychological readiness before surgery.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024514661.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1619959"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the AI tide: challenges, opportunities, and future directions for early-career dermatologists.","authors":"Meng Zhang, Ruiqi Chu, Chunmei Liu, Shengni Zhang, Xiangxiang Ren","doi":"10.3389/fmed.2025.1684035","DOIUrl":"https://doi.org/10.3389/fmed.2025.1684035","url":null,"abstract":"<p><p>Artificial intelligence (AI) has demonstrated diagnostic accuracy comparable to dermatologists in specific tasks (e.g., 92.5% vs. 86.6% for melanoma detection in multicenter trials), while significantly outperforming early-career physicians (15-20% higher accuracy in meta-analyses). This review synthesizes evidence on AI's transformative impact on dermatology training and practice, addressing critical gaps in ethical frameworks and implementation strategies. We propose a competency-based framework for \"AI-augmented dermatology,\" advocating for curriculum integration of AI literacy modules, standardized human-AI workflows, and proactive engagement in regulatory processes. Early-career dermatologists must leverage AI as a safety net while strengthening irreplaceable skills in complex decision-making and patient communication to lead dermatology's AI-integrated future.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1684035"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary ossification: a case report.","authors":"C Di Somma, A Annunziata, A Coppola, G E Polistina, A Marotta, G Fiorentino","doi":"10.3389/fmed.2025.1615806","DOIUrl":"https://doi.org/10.3389/fmed.2025.1615806","url":null,"abstract":"<p><p>Pulmonary calcification and ossification are uncommon findings characterized by the deposition of calcium salts or bone tissue in the lung, generally associated with chronic kidney disease, hyperparathyroidism, and several other causes (1). Ossification is bone formation without or with marrow elements in the lung (1). In some patients, a new entity of subclinical primary hyperparathyroidism has been detected, characterized by persistently elevated parathyroid hormone concentration and normal serum calcium level, usually asymptomatic (2). CT scan is the standard method for detecting calcification and ossification. Radiological presentation on CT is characterized by round or lobulated nodules (3). Follow-up consists of monitoring lung images and lung function to assess disease progression. It suggests an annual CT scan. In this case, we presented a rare association of dendriform ossification with normocalcemic hyperparathyroidism, in particular, in a patient with pulmonary ossification, subclinical primary hyperparathyroidism, and diffuse calcifications.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1615806"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a nomogram for post-hepatectomy liver failure prediction in hepatocellular carcinoma based on pre-operative and perioperative parameters.","authors":"Danni Wang, Qingmei Ma, Lei Zhang, Jinxia Hou, Zhemei Zhang, Jing Wu, Jingheng Zhang","doi":"10.3389/fmed.2025.1670396","DOIUrl":"https://doi.org/10.3389/fmed.2025.1670396","url":null,"abstract":"<p><strong>Objective: </strong>Post-hepatectomy liver failure (PHLF) is a severe complication for hepatocellular carcinoma (HCC) patients post-surgery. This study explores PHLF risk factors and creates a nomogram for prediction using pre- and intraoperative factors.</p><p><strong>Methods: </strong>We retrospectively analyzed 654 patients who underwent hepatectomy. Eligible patients were randomly divided into training and internal validation cohorts in a 7:3 ratio. Key variables for nomogram construction were determined through integrated Least Absolute Shrinkage and Selection Operator (LASSO) and multivariate logistic regression analyses. The nomogram's performance was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>Among 228 eligible patients included in the study, 55 developed PHLF. Seven independent predictors were identified and incorporated into the nomogram: liver cirrhosis, total bilirubin (TBIL), prothrombin time (PT), Albumin-Bilirubin (ALBI), fibrosis-4 index (FIB4), ascites, and intraoperative blood loss. The nomogram demonstrated excellent predictive performance, with area under the curve (AUC) of 0.880 in the training cohort and 0.879 in the validation cohort. Calibration curve and decision curve analysis show that nomogram has significant clinical application value in predicting PHLF probability.</p><p><strong>Conclusion: </strong>We have developed and validated a novel PHLF risk prediction model that integrates pre-operative and intraoperative parameters, along with various liver function scoring systems, enabling more comprehensive and accurate prediction of PHLF risk in HCC patients.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1670396"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal assessment of liver stiffness and risk factors for advanced fibrosis in adolescents with metabolic dysfunction-associated steatotic liver disease: a retrospective observational study.","authors":"Wenshu Cao, Congcong Feng, Jizhong Ye, Jianfeng Zhou, Lin Wang, Yanling Lian","doi":"10.3389/fmed.2025.1657933","DOIUrl":"https://doi.org/10.3389/fmed.2025.1657933","url":null,"abstract":"<p><strong>Background: </strong>The global incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents is steadily increasing. This research aims to characterize adolescents diagnosed with MASLD clinically and evaluate their long-term outcomes in community and tertiary medical centers located in Shanghai. Furthermore, the investigation assesses the diagnostic efficacy of vibration-controlled transient elastography (VCTE) among adolescents with MASLD.</p><p><strong>Methods: </strong>We retrospectively analyzed data from adolescent patients (10-18 years) diagnosed with MASLD referred to Shanghai hospitals during the period 2019-2023. Diagnostic criteria included sustained alanine transaminase elevations exceeding twice the upper normal threshold or radiological confirmation of hepatic steatosis, following exclusion of alternative etiologies. VCTE-derived liver stiffness measurements (LSMs) were classified as normal (≤7.0 kPa, F0-F1), significant fibrosis (7.1-9.0 kPa, F2), and advanced fibrosis (≥9.1 kPa, F3-F4), to distinguish fibrosis severity.</p><p><strong>Results: </strong>A total of 140 adolescents were enrolled (67.9% male), with an average age of 13.8 years. Dyslipidemia was common (48.6%; <i>n</i> = 68), followed by impaired glucose tolerance or diabetes (27.1%; <i>n</i> = 38) and hypertension (21.4%; <i>n</i> = 30). Following a mean follow-up duration of 2.1 years, remission of MASLD occurred in only 8.6% of patients (<i>n</i> = 12). Among the 50 patients evaluated by VCTE, 22 (44%) exhibited normal LSM values, whereas significant fibrosis and advanced fibrosis were suspected in 11 (22%) and 17 (34%) individuals, respectively. Independent risk factors significantly associated with advanced fibrosis included age ≥16 years (OR, 7.18), presence of IGT/DM (OR, 10.16), and elevated aspartate aminotransferase levels exceeding 70 U/L (OR, 17.33).</p><p><strong>Conclusion: </strong>There is a rapid increase in adolescent MASLD incidence in Shanghai. According to LSM assessments, adolescents diagnosed with MASLD may have heightened risks of advanced hepatic fibrosis as they approach late adolescence.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1657933"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mining and analysis of adverse event signals of isotretinoin based on the real-world data of FAERS database.","authors":"Liu Yang, Hanzhang Xie, Ying Jia, Bingnan Cui, Zhanshuo Xiao","doi":"10.3389/fmed.2025.1559972","DOIUrl":"https://doi.org/10.3389/fmed.2025.1559972","url":null,"abstract":"<p><strong>Objective: </strong>Isotretinoin (ISO) is an oral prescription retinoid that is well-known for its effectiveness in treating acne. This study aims to provide valuable insights into the safety of its clinical use by analyzing adverse events (AEs) associated with ISO reported in the FDA Adverse Event Reporting System (FAERS) database.</p><p><strong>Methods: </strong>FAERS data from Q1 2004 to Q2 2024 were analyzed. Duplicate reports were excluded, and disproportionality analysis using four algorithms (ROR, PRR, BCPNN, EBGM) was performed. AEs were classified using MedDRA terms, with Important Medical Events (IMEs) flagged based on the MedDRA IME list.</p><p><strong>Results: </strong>The FAERS database identified 46,526 ISO-related AE reports covering 27 System Organ Classes (SOCs). Of these, 445 AEs showed significant signals across all four algorithms, including 38 previously unlabeled AEs within the top 50 positive Preferred Term (PT) signals. Key IMEs, such as Dandy-Walker syndrome (<i>N</i> = 13), childhood depression (<i>N</i> = 3), and suicidal ideation (<i>N</i> = 2,175), were identified, with Gastrointestinal Disorders being the most frequently reported SOC (10,064 reports). AEs occurred most frequently in the early (0-30 days, 23.5%) and mid-treatment phases (91-180 days, 22.7%), with females accounting for 55.9% of the reports.</p><p><strong>Conclusion: </strong>This study identified previously unlabeled AEs and IMEs associated with ISO, including life-threatening events such as Dandy-Walker syndrome, suicidal ideation, and childhood depression, emphasizing the need for updated drug labels and enhanced safety measures. Future research should focus on mechanisms underlying teratogenicity and psychiatric risks to refine ISO's safety profile.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1559972"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between sarcopenia and osteoporosis in the elderly: a systematic review and meta-analysis.","authors":"Sha Jin, Fengming Zheng, Huaili Liu, Luping Liu, Jie Yu","doi":"10.3389/fmed.2025.1603879","DOIUrl":"https://doi.org/10.3389/fmed.2025.1603879","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia and osteoporosis, as two prevalent geriatric syndromes, synergistically elevate risks of falls, fractures, and disability in older adults. Despite shared pathophysiological mechanisms-including hormonal dysregulation, chronic inflammation, and attenuated mechanical loading. Existing studies have yet to establish consensus regarding the epidemiological association strength and interaction dynamics between sarcopenia and osteoporosis, particularly as heterogeneous characteristics-including sex, geographic region, and population subgroups-remain insufficiently characterized. This study aimed to quantitatively evaluate the sarcopenia-osteoporosis association in older adults through systematic review and meta-analysis of global observational studies, while analyzing the moderating effects of geographic location, sex, population characteristics, and diagnostic criteria on outcomes.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases until September 2024. Fourteen observational studies quantifying muscle mass/function and bone mineral density were included. Two investigators independently performed literature screening and data extraction. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Studies were meta-analyzed by Review Manager 5.4 and Stata 17.0.</p><p><strong>Results: </strong>A total of 14 studies (<i>n</i> = 182307) were included, and the meta-analysis showed that patients with sarcopenia had a significantly higher risk of osteoporosis (OR = 3.16, 95% CI: 2.47 to 4.02, <i>p</i> < 0.001). Subgroup analyses demonstrated an OR of 4.74 [3.19, 7.06] for osteoporosis in the male sarcopenia group compared to females (OR = 3.46; 95% CI, 2.50-4.78). Geographically, European populations exhibited the highest risk (OR = 4.37; 95% CI, 3.72-5.13), surpassing Asian (OR = 2.66; 95% CI, 1.74-4.07) and American cohorts (OR = 2.32; 95% CI, 1.54-3.49). Community-dwelling individuals showed greater susceptibility (OR = 3.70; 95% CI, 3.24-4.23) compared to inpatient and outpatient populations.</p><p><strong>Conclusion: </strong>Our meta-analysis demonstrates that sarcopenia significantly elevates osteoporosis susceptibility, with heterogeneous risk profiles across geographic regions and population subgroups. However, limitations inherent to the methodological quality and sample size of included studies necessitate validation through large-scale prospective cohort investigations.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1603879"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of large language models in decision-making for sustainability in radiology.","authors":"Viktoria Palm, Patricia Leutz-Schmidt, René Michael Mathy, Benedikt Jakob Schwaiger, Hans-Ulrich Kauczor, Hyungseok Jang, Sam Sedaghat","doi":"10.3389/fmed.2025.1632925","DOIUrl":"10.3389/fmed.2025.1632925","url":null,"abstract":"<p><strong>Introduction: </strong>Radiology has a significant environmental impact, but guidance on how to effectively implement sustainable practices in this field is limited. This study investigated the performance of large language models (LLMs) in providing sustainability advice for radiology.</p><p><strong>Methods: </strong>Four state-of-the-art LLMs, namely ChatGPT-4.0 (CGT), Claude 3.5 Sonnet (CS), Gemini Advanced (GA), and Meta Llama 3.1 405b (ML), were evaluated based on their answers to 30 standardized questions covering sustainability topics such as energy consumption, waste management, digitalization, best practices, and carbon footprint. Three experienced readers rated their response for quality (OQS), understandability (US), and implementability (IS) using a 4-point scale. A mean quality score (MQS) was derived from these three attributes.</p><p><strong>Results: </strong>The overall intraclass correlation was good (ICC = 0.702). Across the 30 questions on sustainability in radiology, all four LLMs showed good to very good performances, with the highest ratings being achieved in understandability (CGT/GA/ML 3.91 ± 0.29; CS 3.99 ± 0.11), underlining the excellent language skills of these models. CS emerged as the top performer across most topics, with an MQS of 3.95 ± 0.22, frequently achieving the highest scores. ML showed the second highest performance with an MQS of 3.84 ± 0.37, followed by CGT with an MQS of 3.78 ± 0.42 and GA with an MQS of 3.73 ± 0.44. Accordingly, CGT and GA showed comparable results, while GA consistently received lower mean scores than the other LLMs. None of the LLMs provided answers that were rated insufficient.</p><p><strong>Conclusion: </strong>Our findings highlight the potential of LLMs such as Claude 3.5 Sonnet, ChatGPT-4.0, Meta Llama 3.1, and Gemini Advanced to advance sustainable practices in radiology, with thoughtful model selection further enhancing their positive impact due to model variations.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1632925"},"PeriodicalIF":3.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: A case of unexplained retinoschisis.","authors":"Nan Wang, Yu Zhang, Fuxiang Yuan, Chunning Zhao, Zhanyu Zhou","doi":"10.3389/fmed.2025.1546953","DOIUrl":"10.3389/fmed.2025.1546953","url":null,"abstract":"<p><strong>Background: </strong>Retinoschisis is characterized by separation of the neurosensory retina into two layers. The traditional pars plana vitrectomy with internal limiting membrane peeling and macular buckling has been shown to resolve retinoschisis. We report a case of unknown cause of retinoschisis in a young adult.</p><p><strong>Case presentation: </strong>A 24-year-old man presented with an 18-day history of metamorphopsia and blurred vision in his left eye. Optical coherence tomography revealed retinoschisis in the macula, the temporal side of the macula, and near the superior and inferior vascular arches. The patient was treated with oral corticosteroids. His clinical characteristics and status of retinoschisis were monitored at each visit. The retinoschisis initially became aggravated; however, it had completely resolved by the 40-day follow-up visit.</p><p><strong>Conclusion: </strong>Clinicians should be aware that, for patients with clinically identified posterior vitreous detachment (PVD) without vitreomacular traction (VMT), follow-up observation or empirical treatment with glucocorticoids can be considered to observe the disease outcome.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1546953"},"PeriodicalIF":3.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}