Huang Luwen, Zhang Yunwei, Xu Lei, Li Linlin, Yu Ming
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引用次数: 0
Abstract
Background: This study investigated the association between the cumulative triglyceride-total cholesterol-body weight index (TCBI) and the risk of stroke among middle-aged and older adults, focusing on hypertension as a potential mediator.
Methods: Data from 5,598 participants aged ≥ 45 years in the China Health and Retirement Longitudinal Study were analyzed over a median follow-up of 57.2 months. CumTCBI was calculated as ((TCBI(2011) + TCBI(2015))/2) × (2015-2011). The risk of stroke was the primary outcome. Cox proportional hazards models and restricted cubic splines were used to examine the association between CumTCBI and stroke risk. Mediation analysis investigated the role of hypertension as a potential mediator of the association between CumTCBI and stroke risk.
Results: During the follow-up period, 480 (8.93%) participants experienced stroke. The fully adjusted CumTCBI was significantly associated with stroke (HR per 1 SD = 1.166). A non-linearly association was observed, with stroke risk increasing when CumTCBI was below 12.639 (HR per 100 units = 1.166, P = 0.002) and remaining stable beyond this threshold (P = 0.356). Additionally, hypertension mediated 27.4% of the association.
Conclusion: CumTCBI is non-linearly associated with stroke risk, partially mediated by hypertension. Managing both metabolic status and hyperternsion may reduce stroke risk in aging populations.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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