Frontiers in Neuroendocrinology最新文献_第6页

The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities 肠道微生物组在双相情感障碍及其常见医学合并症中的作用

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101078

Gregory H. Jones , Omar F. Pinjari , Courtney M. Vecera , Kacy Smith , Anita Barrera , Rodrigo Machado-Vieira

{"title":"The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities","authors":"Gregory H. Jones , Omar F. Pinjari , Courtney M. Vecera , Kacy Smith , Anita Barrera , Rodrigo Machado-Vieira","doi":"10.1016/j.yfrne.2023.101078","DOIUrl":"10.1016/j.yfrne.2023.101078","url":null,"abstract":"<div><p>Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this population. In that regard, gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory disorders. Microbial impact on immune, endocrine, endocannabinoid, kynurenine, and other pathways are discussed throughout this review. Emphasis is placed on this system’s relevance to current pharmacology, diet, and comorbid illness in bipolar disorder. Despite the high level of optimism promoted in many reviews on this topic, substantial obstacles exist before any microbiome-related findings can provide meaningful clinical utility. Beyond a comprehensive overview of pathophysiology, this review hopes to highlight several key areas where progress is needed. As well, novel microbiome-associated suggestions are presented for future research.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101078"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The historical progression of positron emission tomography research in neuroendocrinology 神经内分泌学正电子发射断层扫描研究的历史进展。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101081

Jason Bini

引用次数: 0

Neuroendocrine mechanisms contributing to the coevolution of sociality and communication 神经内分泌机制有助于社会性和沟通的共同进化。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101077

Megan K. Freiler, G. Troy Smith

{"title":"Neuroendocrine mechanisms contributing to the coevolution of sociality and communication","authors":"Megan K. Freiler, G. Troy Smith","doi":"10.1016/j.yfrne.2023.101077","DOIUrl":"10.1016/j.yfrne.2023.101077","url":null,"abstract":"<div><p>Communication is inherently social, so signaling systems should evolve with social systems. The ‘social complexity hypothesis’ posits that social complexity necessitates communicative complexity and is generally supported in vocalizing mammals. This hypothesis, however, has seldom been tested outside the acoustic modality, and comparisons across studies are confounded by varying definitions of complexity. Moreover, proximate mechanisms underlying coevolution of sociality and communication remain largely unexamined. In this review, we argue that to uncover how sociality and communication coevolve, we need to examine variation in the neuroendocrine mechanisms that coregulate social behavior and signal production and perception. Specifically, we focus on steroid hormones, monoamines, and nonapeptides, which modulate both social behavior and sensorimotor circuits and are likely targets of selection during social evolution. Lastly, we highlight weakly electric fishes as an ideal system in which to comparatively address the proximate mechanisms underlying relationships between social and signal diversity in a novel modality.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101077"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10306061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal contraception and cognition: Considering the influence of endogenous ovarian hormones and genes for clinical translation 激素避孕与认知:考虑卵巢内源性激素及基因的影响进行临床翻译

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101067

Laura Gravelsins , Sophia Zhao , Gillian Einstein

引用次数: 0

The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies 自闭症谱系障碍的神经胶质视角:来自死后脑和PET研究的证据

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101064

Xiaoli Liao , Miao Chen , Yamin Li

{"title":"The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies","authors":"Xiaoli Liao , Miao Chen , Yamin Li","doi":"10.1016/j.yfrne.2023.101064","DOIUrl":"10.1016/j.yfrne.2023.101064","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aimed to systematically and quantitatively review evidence derived from both postmortem brain and PET studies to explore the pathological role of glia induced neuroinflammation in the pathogenesis of ASD, and discuss the implications of these findings in relation to disease pathogenesis and therapeutic strategies.</p></div><div><h3>Method</h3><p>An online databases search was performed to collate postmortem studies and PET studies regarding glia induced neuroinflammation in ASD as compared to controls. Two authors independently conducted the literature search, study selection and data extraction. The discrepancies generated in these processes was resolved through robust discussions among all authors.</p></div><div><h3>Result</h3><p>The literature search yielded the identification of 619 records, from which 22 postmortem studies and 3 PET studies were identified as eligible for the qualitative synthesis. Meta-analysis of postmortem studies reported increased microglial number and microglia density as well as increased GFAP protein expression and GFAP mRNA expression in ASD subjects as compared to controls. Three PET studies produced different outcomes and emphasized different details, with one reported increased and two reported decreased TSPO expression in ASD subjects as compared to controls.</p></div><div><h3>Conclusion</h3><p>Both postmortem evidences and PET studies converged to support the involvement of glia induced neuroinflammation in the pathogenesis of ASD. The limited number of included studies along with the considerable heterogeneity of these studies prevented the development of firm conclusions and challenged the explanation of variability. Future research should prioritize the replication of current studies and the validation of current observations.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101064"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9969334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies 以食欲素/下丘脑泌素系统为靶点治疗神经精神和神经退行性疾病:从动物到临床研究

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101066

Marc Ten-Blanco , África Flores , Luigia Cristino , Inmaculada Pereda-Pérez , Fernando Berrendero

引用次数: 4

The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review 照顾慢性病儿童对HPA轴的影响:一项范围审查

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101062

Lindsey Mountcastle , Melissa Zajdel , Taylor Robinson , Krystyna R. Keller , Shani Gelles , Alicia A. Livinski , Bijal Kikani , Dawn E. Lea , Laura M. Koehly

{"title":"The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review","authors":"Lindsey Mountcastle , Melissa Zajdel , Taylor Robinson , Krystyna R. Keller , Shani Gelles , Alicia A. Livinski , Bijal Kikani , Dawn E. Lea , Laura M. Koehly","doi":"10.1016/j.yfrne.2023.101062","DOIUrl":"10.1016/j.yfrne.2023.101062","url":null,"abstract":"<div><p>Caregiving has been robustly linked to caregiver health through the dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis in the context of caregiving for an adult with a chronic illness. However, little research examines the physiological impact of caregiving for a child with a chronic illness despite high burden and unique stressors. In this review, we explore the links of caregiving for a child with a congenital, chromosomal, or genetic disorder to the regulation or dysregulation of the HPA axis. A search was conducted in PubMed, Embase, and the Web of Science and 15 studies met inclusion criteria. Overall, there were inconsistent links of caregiving to HPA axis functioning, perhaps due to the heterogeneity across disease contexts, study designs, and biomarker measurement. Future research should standardize measurement and study designs, increase participant diversity, and examine moderators of the links of caregiving to the HPA axis.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"69 ","pages":"Article 101062"},"PeriodicalIF":7.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease 孤独和社会隔离对认知能力下降和阿尔茨海默病发展的影响

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101061

Yi Ren , Aisouda Savadlou , Soobin Park , Paul Siska , Jonathan R. Epp , Derya Sargin

引用次数: 9

Stress in adolescence as a first hit in stress-related disease development: Timing and context are crucial 青春期的压力是压力相关疾病发展的第一个打击:时间和环境至关重要

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101065

Giulia F. Mancini , Onno C. Meijer , Patrizia Campolongo

引用次数: 0

Progesterone and contraceptive progestin actions on the brain: A systematic review of animal studies and comparison to human neuroimaging studies 黄体酮和避孕黄体酮对大脑的作用:动物研究的系统回顾和与人类神经影像学研究的比较

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101060

Belinda Pletzer , Katharina Winkler-Crepaz , Katharina Maria Hillerer

{"title":"Progesterone and contraceptive progestin actions on the brain: A systematic review of animal studies and comparison to human neuroimaging studies","authors":"Belinda Pletzer , Katharina Winkler-Crepaz , Katharina Maria Hillerer","doi":"10.1016/j.yfrne.2023.101060","DOIUrl":"10.1016/j.yfrne.2023.101060","url":null,"abstract":"<div><p>In this review we systematically summarize the effects of progesterone and synthetic progestins on neurogenesis, synaptogenesis, myelination and six neurotransmitter systems. Several parallels between progesterone and older generation progestin actions emerged, suggesting actions via progesterone receptors. However, existing results suggest a general lack of knowledge regarding the effects of currently used progestins in hormonal contraception regarding these cellular and molecular brain parameters. Human neuroimaging studies were reviewed with a focus on randomized placebo-controlled trials and cross-sectional studies controlling for progestin type. The prefrontal cortex, amygdala, salience network and hippocampus were identified as regions of interest for future preclinical studies. This review proposes a series of experiments to elucidate the cellular and molecular actions of contraceptive progestins in these areas and link these actions to behavioral markers of emotional and cognitive functioning. Emotional effects of contraceptive progestins appear to be related to 1) alterations in the serotonergic system, 2) direct/indirect modulations of inhibitory GABA-ergic signalling via effects on the allopregnanolone content of the brain, which differ between androgenic and anti-androgenic progestins. Cognitive effects of combined oral contraceptives appear to depend on the ethinylestradiol dose.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"69 ","pages":"Article 101060"},"PeriodicalIF":7.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6