Frontiers in Neuroendocrinology最新文献_第5页

Androgen action on myogenesis throughout the lifespan; comparison with neurogenesis 一生中雄激素对肌肉形成的作用;神经发生的比较

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-10-01 DOI: 10.1016/j.yfrne.2023.101101

Sabrina Tzivia Barsky , Douglas Ashley Monks

{"title":"Androgen action on myogenesis throughout the lifespan; comparison with neurogenesis","authors":"Sabrina Tzivia Barsky , Douglas Ashley Monks","doi":"10.1016/j.yfrne.2023.101101","DOIUrl":"10.1016/j.yfrne.2023.101101","url":null,"abstract":"<div><p>Androgens’ pleiotropic actions in promoting sex differences present not only a challenge to providing a comprehensive account of their function, but also an opportunity to gain insights by comparing androgenic actions across organ systems. Although often overlooked by neuroscientists, skeletal muscle is another androgen-responsive organ system which shares with the nervous system properties of electrochemical excitability, behavioral relevance, and remarkable capacity for adaptive plasticity. Here we review androgenic regulation of mitogenic plasticity in skeletal muscle with the goal of identifying areas of interest to those researching androgenic mechanisms mediating sexual differentiation of neurogenesis. We use an organizational-activational framework to relate broad areas of similarity and difference between androgen effects on mitogenesis in muscle and brain throughout the lifespan, from early organogenesis, through pubertal organization, adult activation, and aging. The focus of the review is androgenic regulation of muscle-specific stem cells (satellite cells), which share with neural stem cells essential functions in development, plasticity, and repair, albeit with distinct, muscle-specific features. Also considered are areas of paracrine and endocrine interaction between androgen action on muscle and nervous system, including mediation of neural plasticity of innervating and distal neural populations by muscle-produced trophic factors.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"71 ","pages":"Article 101101"},"PeriodicalIF":7.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insufficient support for retinoic acid receptor control of synaptic plasticity through a non-genomic mechanism 维甲酸受体通过非基因组机制控制突触可塑性的支持不足

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-10-01 DOI: 10.1016/j.yfrne.2023.101099

Gregg Duester

引用次数: 0

Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review 唾液分泌免疫球蛋白A作为生命初期社会心理应激反应的潜在生物标志物:系统综述

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-10-01 DOI: 10.1016/j.yfrne.2023.101083

Águeda Castro-Quintas , Helena Palma-Gudiel , Nerea San Martín-González , Javier R. Caso , Juan C. Leza , Lourdes Fañanás

{"title":"Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review","authors":"Águeda Castro-Quintas , Helena Palma-Gudiel , Nerea San Martín-González , Javier R. Caso , Juan C. Leza , Lourdes Fañanás","doi":"10.1016/j.yfrne.2023.101083","DOIUrl":"10.1016/j.yfrne.2023.101083","url":null,"abstract":"<div><p>Mucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children older than 9 years old exposed to stress. Furthermore, s-IgA seems to follow a circadian rhythm, which is altered under stress conditions. Finally, the collective evidence suggests that salivary s-IgA rapidly increases under acute stress after puberty. Overall, our review indicates that s-IgA could be considered a potential psychosocial stress biomarker of interest for pediatric and child-juvenile psychiatric population. Further studies are needed to validate the role of s-IgA circadian rhythm and basal levels as psychosocial stress biomarkers and disentangle the role of age and type of stressor.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"71 ","pages":"Article 101083"},"PeriodicalIF":7.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9877040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research 神经系统疾病与生殖内分泌功能障碍的联系机制:来自癫痫研究的见解

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-10-01 DOI: 10.1016/j.yfrne.2023.101084

Cathryn A. Cutia , Catherine A. Christian-Hinman

{"title":"Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research","authors":"Cathryn A. Cutia , Catherine A. Christian-Hinman","doi":"10.1016/j.yfrne.2023.101084","DOIUrl":"10.1016/j.yfrne.2023.101084","url":null,"abstract":"<div><p>Gonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary–gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from temporal lobe structures, can drive HPG axis alterations, and hormones produced in the HPG axis can reciprocally modulate seizure activity. Despite this relationship, mechanistic links between seizures and RED, and vice versa, are still largely unknown. Here, we review clinical evidence alongside recent investigations in preclinical animal models into the contributions of seizures to HPG axis malfunction, describe the effects of HPG axis hormonal feedback on seizure activity, and discuss how epilepsy research can offer insight into mechanisms linking neurological disorders to HPG axis dysfunction, an understudied area of neuroendocrinology.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"71 ","pages":"Article 101084"},"PeriodicalIF":7.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fast neurotransmitter identity of MCH neurons: Do contents depend on context? MCH神经元的快速神经递质识别:内容依赖于环境吗?

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101069

B.G. Beekly , A. Rupp , C.R. Burgess , C.F. Elias

引用次数: 0

Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies 社区居住成人维生素D状态和认知表现:观察性研究的剂量-反应荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101080

Janis D. Harse , Ross J. Marriott , Kun Zhu , Kevin Murray , Romola S. Bucks

{"title":"Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies","authors":"Janis D. Harse , Ross J. Marriott , Kun Zhu , Kevin Murray , Romola S. Bucks","doi":"10.1016/j.yfrne.2023.101080","DOIUrl":"10.1016/j.yfrne.2023.101080","url":null,"abstract":"<div><p>Low vitamin D status is linked with poorer cognition in adults while findings in relation to high levels are mixed.We performed a systematic review and <em>meta</em>-analyses to examine dose–response associations between 25-hydroxyvitamin D (25OHD) levelsand cognitive performance in community-dwelling adults. Thirty-eight observational studies were included in dose–response <em>meta</em>-analyses. Positive, nonlinear associations were identified between baseline25OHD levels and global cognition incross-sectional and longitudinal analyses, and for performance in memory and executive function in longitudinal analyses. When restricted to studies involving older adults, thepattern emerged forspecific domains in cross-sectional analyses. Poorer performance was associated with low 25OHD levels, while a sharp improvement was associated withlevels up to 60–70 nM/L. Further improvement was observed only for longitudinal global cognition. Our findings support the association between low vitamin D and poorer cognition and suggest levels of at least 60 nM/L are associated with better cognition during ageing.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101080"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9946457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Women are taking the hit: Examining the unique consequences of cannabis use across the female lifespan 女性正在遭受打击:研究大麻使用在女性生命周期中的独特后果

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101076

E.L. Gräfe , H.M.O. Reid , I. Shkolnikov , K. Conway , A. Kit , C. Acosta , B.R. Christie

引用次数: 2

Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies 异位脂肪对大脑结构和认知功能的影响:观察性研究的系统回顾和荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101082

Zhi-Hui Song , Jing Liu , Xiao-Feng Wang , Rafael Simó , Chao Zhang , Jian-Bo Zhou

{"title":"Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies","authors":"Zhi-Hui Song , Jing Liu , Xiao-Feng Wang , Rafael Simó , Chao Zhang , Jian-Bo Zhou","doi":"10.1016/j.yfrne.2023.101082","DOIUrl":"10.1016/j.yfrne.2023.101082","url":null,"abstract":"<div><p>Ectopic fat, defined as a specific organ or compartment with the accumulation of fat tissue surrounding organs, is highly associated with obesity which has been identified as a risk factor for cognitive impairment and dementia. However, the relationship between ectopic fat and changes in brain structure or cognition is yet to be elucidated. Here, we investigated the effects of ectopic fat on brain structure and cognitive function via systemic review and meta-analysis. A total of 21 studies were included from electronic databases up to July 9, 2022.</p><p>We found ectopic fat was associated with decreased total brain volumeand increased lateral ventricle volume. In addition, ectopic was associated with decreased cognitive scores and negatively correlated with cognitive function. More specifically, dementia development were correlated with increased levels of visceral fat. Overall, our data suggested that increased ectopic fat was associated with prominent structural changes in the brain and cognitive decline, an effect driven mainly by increases in visceral fat, while subcutaneous fat may be protective. Our results suggest that patients with increased visceral fat are at risk of developing cognitive impairment and, therefore, represent a subset of population in whom appropriate and timely preventive measures could be implemented.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101082"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging 心脏代谢健康、绝经期雌激素治疗和大脑:雌激素在健康和不健康的衰老临床前模型中的作用是如何不同的

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101068

Jill M. Daniel , Sarah H. Lindsey , Ricardo Mostany , Laura A. Schrader , Andrea Zsombok

{"title":"Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging","authors":"Jill M. Daniel , Sarah H. Lindsey , Ricardo Mostany , Laura A. Schrader , Andrea Zsombok","doi":"10.1016/j.yfrne.2023.101068","DOIUrl":"10.1016/j.yfrne.2023.101068","url":null,"abstract":"<div><p>Research in preclinical models indicates that estrogens are neuroprotective and positively impact cognitive aging. However, clinical data are equivocal as to the benefits of menopausal estrogen therapy to the brain and cognition. Pre-existing cardiometabolic disease may modulate mechanisms by which estrogens act, potentially reducing or reversing protections they provide against cognitive decline. In the current review we propose mechanisms by which cardiometabolic disease may alter estrogen effects, including both alterations in actions directly on brain memory systems and actions on cardiometabolic systems, which in turn impact brain memory systems. Consideration of mechanisms by which estrogen administration can exert differential effects dependent upon health phenotype is consistent with the move towards precision or personalized medicine, which aims to determine which treatment interventions will work for which individuals. Understanding effects of estrogens in both healthy and unhealthy models of aging is critical to optimizing the translational link between preclinical and clinical research.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101068"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9940160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women’s use of alcohol: Neurobiobehavioral concomitants and consequences 女性饮酒:神经生物行为伴随物及其后果

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101079

Sara Jo Nixon , Christian C. Garcia , Ben Lewis

引用次数: 0