Neuroestradiol and neuronal development: Not an exclusive male tale anymore

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2023-10-01 DOI:10.1016/j.yfrne.2023.101102

Luis M. Garcia-Segura , Pablo Méndez , M. Angeles Arevalo , Iñigo Azcoitia

{"title":"Neuroestradiol and neuronal development: Not an exclusive male tale anymore","authors":"Luis M. Garcia-Segura , Pablo Méndez , M. Angeles Arevalo , Iñigo Azcoitia","doi":"10.1016/j.yfrne.2023.101102","DOIUrl":null,"url":null,"abstract":"<div><p>The brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain development. In addition, recent findings have shown sex-specific actions of neuroestradiol on neuroblast migration, neuritic growth and synaptogenesis in females. Among other factors, the epigenetic regulation exerted by X linked genes, such as <em>Kdm6a/Utx</em>, may determine sex-specific actions of neuroestradiol in the female brain. This review evidences the impact of neuroestradiol on brain formation in both sexes and highlights the interaction of neural steriodogenesis, hormones and sex chromosomes in sex-specific brain development.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"71 ","pages":"Article 101102"},"PeriodicalIF":6.5000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neuroendocrinology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S009130222300050X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

The brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain development. In addition, recent findings have shown sex-specific actions of neuroestradiol on neuroblast migration, neuritic growth and synaptogenesis in females. Among other factors, the epigenetic regulation exerted by X linked genes, such as Kdm6a/Utx, may determine sex-specific actions of neuroestradiol in the female brain. This review evidences the impact of neuroestradiol on brain formation in both sexes and highlights the interaction of neural steriodogenesis, hormones and sex chromosomes in sex-specific brain development.

Abstract Image

查看原文本刊更多论文

神经雌二醇和神经元发育:不再是男性独有的故事

大脑合成了多种神经类固醇，包括神经雌二醇。神经雌二醇合成的抑制导致基本神经发育过程的改变，如神经发生、神经母细胞迁移、神经炎发生和突触发生。尽管神经雌二醇的神经发育作用在两性中都有，但其中一些是性别特异性的，例如在男性大脑发育的关键时期，源自睾丸睾酮代谢的神经雌二醇具有良好的特征性作用。此外，最近的研究结果表明，神经雌二醇对女性神经母细胞迁移、神经炎生长和突触发生具有性别特异性作用。在其他因素中，由X连锁基因（如Kdm6a/Utx）施加的表观遗传学调控可能决定神经雌二醇在女性大脑中的性别特异性作用。这篇综述证明了神经雌二醇对两性大脑形成的影响，并强调了神经空间生成、激素和性染色体在性别特异性大脑发育中的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.