Frontiers in Neuroendocrinology最新文献_第7页

Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier 褪黑素与脑屏障：褪黑激素对血脑屏障和血脑脊液屏障的保护作用

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI: 10.1016/j.yfrne.2024.101158

Rafael Mineiro , Maria Rodrigues Cardoso , Ana Catarina Duarte , Cecília Santos , Jose Cipolla-Neto , Fernanda Gaspar do Amaral , Diana Costa , Telma Quintela

{"title":"Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier","authors":"Rafael Mineiro , Maria Rodrigues Cardoso , Ana Catarina Duarte , Cecília Santos , Jose Cipolla-Neto , Fernanda Gaspar do Amaral , Diana Costa , Telma Quintela","doi":"10.1016/j.yfrne.2024.101158","DOIUrl":"10.1016/j.yfrne.2024.101158","url":null,"abstract":"<div><div>The blood–brain barrier and the blood-cerebrospinal fluid barrier separate the blood from brain tissue and cerebrospinal fluid. These brain barriers are important to maintain homeostasis and complex functions by protecting the brain from xenobiotics and harmful endogenous compounds. The disruption of brain barriers is a characteristic of neurologic diseases. Melatonin is a lipophilic hormone that is mainly produced by the pineal gland. The blood–brain barrier and the blood-cerebrospinal fluid barriers are melatonin-binding sites. Among the several melatonin actions, the most characteristic one is the regulation of sleep-wake cycles, melatonin has anti-inflammatory and antioxidant properties. Since brain barriers disruption can arise from inflammation and oxidative stress, knowing the influence of melatonin on the integrity of brain barriers is extremely important. Therefore, the objective of this review is to gather and discuss the available literature about the regulation of brain barriers by melatonin.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101158"},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease 5-α 还原酶抑制剂对帕金森病动物模型的影响。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-10-01 Epub Date: 2024-09-29 DOI: 10.1016/j.yfrne.2024.101156

Mélanie Bourque , Marc Morissette , Amandine Isenbrandt , Silvia Giatti , Roberto Cosimo Melcangi , Manolo Carta , Roberto Frau , Marco Bortolato , Denis Soulet , Thérèse Di Paolo

{"title":"Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease","authors":"Mélanie Bourque , Marc Morissette , Amandine Isenbrandt , Silvia Giatti , Roberto Cosimo Melcangi , Manolo Carta , Roberto Frau , Marco Bortolato , Denis Soulet , Thérèse Di Paolo","doi":"10.1016/j.yfrne.2024.101156","DOIUrl":"10.1016/j.yfrne.2024.101156","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is characterized by motor symptoms due to loss of brain dopamine and non-motor symptoms, including gastrointestinal disorders. Although there is no cure for PD, symptomatic treatments are available. L-Dopa is the gold standard PD therapy, but most patients develop dyskinesias (LID), which are challenging to manage. Amantadine is recognized as the most effective drug for LID, but its adverse effects limit the use in patients. Here we review how 5α-reductase inhibitors (5ARIs), drugs used to treat benign prostatic hyperplasia and alopecia, exhibit beneficial effects in PD animal models. 5ARIs show neuroprotective properties in brain and gut dopaminergic systems, and reduce dyskinesias in rodent model of PD. Additionally, the 5ARI finasteride dampened dopaminergic-induced drug gambling in PD patients. Neuroprotection and antidyskinetic activities of 5ARIs in animal models of PD suggest their potential repurposing in men with PD to address gut dysfunction, protect brain DA and inhibit dyskinesias.</div></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"75 ","pages":"Article 101156"},"PeriodicalIF":6.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging role of rapid corticosteroid actions on excitatory and inhibitory synaptic signaling in the brain 皮质类固醇对大脑兴奋性和抑制性突触信号传递的快速作用。

IF 6.5 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-07-01 Epub Date: 2024-07-14 DOI: 10.1016/j.yfrne.2024.101146

Marian Joëls , Henk Karst , Jeffrey G. Tasker

{"title":"The emerging role of rapid corticosteroid actions on excitatory and inhibitory synaptic signaling in the brain","authors":"Marian Joëls , Henk Karst , Jeffrey G. Tasker","doi":"10.1016/j.yfrne.2024.101146","DOIUrl":"10.1016/j.yfrne.2024.101146","url":null,"abstract":"<div><p>Over the past two decades, there has been increasing evidence for the importance of rapid-onset actions of corticosteroid hormones in the brain. Here, we highlight the distinct rapid corticosteroid actions that regulate excitatory and inhibitory synaptic transmission in the hypothalamus, the hippocampus, basolateral amygdala, and prefrontal cortex. The receptors that mediate rapid corticosteroid actions are located at or close to the plasma membrane, though many of the receptor characteristics remain unresolved. Rapid-onset corticosteroid effects play a role in fast neuroendocrine feedback as well as in higher brain functions, including increased aggression and anxiety, and impaired memory retrieval. The rapid non-genomic corticosteroid actions precede and complement slow-onset, long-lasting transcriptional actions of the steroids. Both rapid and slow corticosteroid actions appear to be indispensable to adapt to a continuously changing environment, and their imbalance can increase an individual’s susceptibility to psychopathology.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"74 ","pages":"Article 101146"},"PeriodicalIF":6.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000268/pdfft?md5=ed5c2dd9ec5d11f96ed806ffed5069e1&pid=1-s2.0-S0091302224000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion recognition and regulation in males: Role of sex and stress steroids 男性的情绪识别和调节：性别和应激类固醇的作用

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-07-01 Epub Date: 2024-06-09 DOI: 10.1016/j.yfrne.2024.101145

Erik Ilkevič , Markus Hausmann , Ramunė Grikšienė

{"title":"Emotion recognition and regulation in males: Role of sex and stress steroids","authors":"Erik Ilkevič , Markus Hausmann , Ramunė Grikšienė","doi":"10.1016/j.yfrne.2024.101145","DOIUrl":"10.1016/j.yfrne.2024.101145","url":null,"abstract":"<div><p>Understanding emotions in males is crucial given their higher susceptibility to substance use, interpersonal violence, and suicide compared to females. Steroid hormones are assumed to be critical biological factors that affect and modulate emotion-related behaviors, together with psychological and social factors. This review explores whether males‘ abilities to recognize emotions of others and regulate their own emotions are associated with testosterone, cortisol, and their interaction. Higher levels of testosterone were associated with improved recognition and heightened sensitivity to threatening faces. In contrast, higher cortisol levels positively impacted emotion regulation ability. Indirect evidence from neuroimaging research suggested a link between higher testosterone levels and difficulties in cognitive emotion regulation. However, this notion must be investigated in future studies using different emotion regulation strategies and considering social status. The present review contributes to the understanding of how testosterone and cortisol affect psychological well-being and emotional behavior in males.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"74 ","pages":"Article 101145"},"PeriodicalIF":7.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel insights into the activating transcription factor 4 in Alzheimer’s disease and associated aging-related diseases: Mechanisms and therapeutic implications 激活转录因子 4 在阿尔茨海默氏症和相关衰老疾病中的新发现：机制和治疗意义

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-07-01 Epub Date: 2024-05-24 DOI: 10.1016/j.yfrne.2024.101144

Nan Zhang , Jianfei Nao , Shun Zhang , Xiaoyu Dong

{"title":"Novel insights into the activating transcription factor 4 in Alzheimer’s disease and associated aging-related diseases: Mechanisms and therapeutic implications","authors":"Nan Zhang , Jianfei Nao , Shun Zhang , Xiaoyu Dong","doi":"10.1016/j.yfrne.2024.101144","DOIUrl":"10.1016/j.yfrne.2024.101144","url":null,"abstract":"<div><p>Ageing is inherent to all human beings, most mechanistic explanations of ageing results from the combined effects of various physiological and pathological processes. Additionally, aging pivotally contributes to several chronic diseases. Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding protein family, has recently emerged as a pivotal player owing to its indispensable role in the pathophysiological processes of Alzheimer’s disease and aging-related diseases. Moreover, ATF4 is integral to numerous biological processes. Therefore, this article aims to comprehensively review relevant research on the role of ATF4 in the onset and progression of aging-related diseases, elucidating its potential mechanisms and therapeutic approaches. Our objective is to furnish scientific evidence for the early identification of risk factors in aging-related diseases and pave the way for new research directions for their treatment. By elucidating the signaling pathway network of ATF4 in aging-related diseases, we aspire to gain a profound understanding of the molecular and cellular mechanisms, offering novel strategies for addressing aging and developing related therapeutics.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"74 ","pages":"Article 101144"},"PeriodicalIF":7.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nestorone (segesterone acetate) effects on neuroregeneration Nestorone（醋酸雌甾醇）对神经再生的影响

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 Epub Date: 2024-04-25 DOI: 10.1016/j.yfrne.2024.101136

Regine Sitruk-Ware , Heather Sussman , Roberta Brinton , Michael Schumacher , Patrick Singer , Narender Kumar , Alejandro F. De Nicola , Martine El-Etr , Rachida Guennoun , Cesar V Borlongan

{"title":"Nestorone (segesterone acetate) effects on neuroregeneration","authors":"Regine Sitruk-Ware , Heather Sussman , Roberta Brinton , Michael Schumacher , Patrick Singer , Narender Kumar , Alejandro F. De Nicola , Martine El-Etr , Rachida Guennoun , Cesar V Borlongan","doi":"10.1016/j.yfrne.2024.101136","DOIUrl":"10.1016/j.yfrne.2024.101136","url":null,"abstract":"<div><p>Nestorone® (segesterone acetate) is a progestin with a chemical structure closely related to progesterone with high affinity and selectivity for the progesterone receptor without significant interaction with other steroid receptors. It has been developed for female and male contraception and is FDA-approved in a first long-acting contraceptive vaginal system for female contraception. Its safety has been extensively demonstrated in both preclinical and clinical studies for contraceptive indications. Nestorone was found to display neuroprotective and neuroregenerative activity in animal models of various central nervous system diseases, including multiple sclerosis, stroke, and amyotrophic lateral sclerosis. Reviewed herein are neuroprotective and myelin- regenerating properties of Nestorone in various animal models and its translational potential as a therapeutic agent for debilitating neurological diseases for which limited therapeutic options are available (<span>Table 1</span>).</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101136"},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis 钠-葡萄糖共转运体-2抑制剂及其在糖尿病患者痴呆症发病和认知功能方面的潜在作用：系统综述和荟萃分析。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 Epub Date: 2024-02-16 DOI: 10.1016/j.yfrne.2024.101131

Yea Jin Youn , Seungyeon Kim , Hyun-Jeong Jeong , Young-Mi Ah , Yun Mi Yu

{"title":"Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis","authors":"Yea Jin Youn , Seungyeon Kim , Hyun-Jeong Jeong , Young-Mi Ah , Yun Mi Yu","doi":"10.1016/j.yfrne.2024.101131","DOIUrl":"10.1016/j.yfrne.2024.101131","url":null,"abstract":"<div><p>This systematic review and meta-analysis aimed to determine the association between the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as cognitive function in patients with diabetes mellitus. We comprehensively searched the MEDLINE, Embase, and CENTRAL databases to select relevant studies published up to August 2023. The use of SGLT-2 inhibitors significantly lowers dementia risk compared to SGLT-2i non-users (Hazard ratio: 0.68, 95 % CI: 0.50–0.92). Furthermore, our findings indicated a positive effect of SGLT-2 inhibitor use on cognitive function score improvement, as demonstrated by the standardized mean difference of 0.88 (95 % CI: 0.32–1.44), particularly among populations with mild cognitive impairment or dementia. This systematic review and meta-analysis indicate a potential role of SGLT-2 inhibitors in reducing the risk of dementia in patients with diabetes mellitus. These findings underscore the need for well-controlled large clinical trials and future research in this field.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101131"},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302224000116/pdfft?md5=d705299bbfab00768568ceb8fabe2a5c&pid=1-s2.0-S0091302224000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications 神经类固醇在创伤后应激障碍和酒精使用障碍中的作用：10 年临床文献回顾及治疗意义

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 Epub Date: 2024-01-04 DOI: 10.1016/j.yfrne.2023.101119

MacKenzie R. Peltier , Terril L. Verplaetse , Margaret Altemus , Yasmin Zakiniaeiz , Elizabeth A. Ralevski , Yann S. Mineur , Ralitza Gueorguieva , Marina R. Picciotto , Kelly P. Cosgrove , Ismene Petrakis , Sherry A. McKee

{"title":"The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications","authors":"MacKenzie R. Peltier , Terril L. Verplaetse , Margaret Altemus , Yasmin Zakiniaeiz , Elizabeth A. Ralevski , Yann S. Mineur , Ralitza Gueorguieva , Marina R. Picciotto , Kelly P. Cosgrove , Ismene Petrakis , Sherry A. McKee","doi":"10.1016/j.yfrne.2023.101119","DOIUrl":"10.1016/j.yfrne.2023.101119","url":null,"abstract":"<div><p>Rates of alcohol use disorder (AUD) are increasing in men and women and there are high rates of concurrent posttraumatic stress disorder (PTSD) and AUD. AUD and PTSD synergistically increase symptomatology and negatively affect treatment outcomes; however, there are very limited pharmacological treatments for PTSD/AUD. Neurosteroids have been implicated in the underlying neurobiological mechanisms of both PTSD and AUD and may be a target for treatment development. This review details the past ten years of research on pregnenolone, progesterone, allopregnanolone, pregnanolone, estradiol, testosterone and dehydroepiandrosterone/dehydroepiandrosterone-sulfate (DHEA/DHEA-S) in the context of PTSD and AUD, including examination of trauma/alcohol-related variables, such as stress-reactivity. Emerging evidence that exogenous pregnenolone, progesterone, and allopregnanolone may be promising, novel interventions is also discussed. Specific emphasis is placed on examining the application of sex as a biological variable in this body of literature, given that women are more susceptible to both PTSD diagnoses and stress-related alcohol consumption.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101119"},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139105082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The research landscape concerning environmental factors in neurodevelopmental disorders: Endocrine disrupters and pesticides—A review 有关神经发育障碍环境因素的研究概况：内分泌干扰素和杀虫剂--综述。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 Epub Date: 2024-03-30 DOI: 10.1016/j.yfrne.2024.101132

Rebeca Mira Sánchez , Juan Felipe Bermeo Losada , Juan Antonio Marín Martínez

{"title":"The research landscape concerning environmental factors in neurodevelopmental disorders: Endocrine disrupters and pesticides—A review","authors":"Rebeca Mira Sánchez , Juan Felipe Bermeo Losada , Juan Antonio Marín Martínez","doi":"10.1016/j.yfrne.2024.101132","DOIUrl":"10.1016/j.yfrne.2024.101132","url":null,"abstract":"<div><p>In recent years, environmental epidemiology and toxicology have seen a growing interest in the environmental factors that contribute to the increased prevalence of neurodevelopmental disorders, with the purpose of establishing appropriate prevention strategies. A literature review was performed, and 192 articles covering the topic of endocrine disruptors and neurodevelopmental disorders were found, focusing on polychlorinated biphenyls, polybrominated diphenyl ethers, bisphenol A, and pesticides. This study contributes to analyzing their effect on the molecular mechanism in maternal and infant thyroid function, essential for infant neurodevelopment, and whose alteration has been associated with various neurodevelopmental disorders. The results provide scientific evidence of the association that exists between the environmental neurotoxins and various neurodevelopmental disorders. In addition, other possible molecular mechanisms by which pesticides and endocrine disruptors may be associated with neurodevelopmental disorders are being discussed.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"73 ","pages":"Article 101132"},"PeriodicalIF":7.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating 60 years of neuroendocrinology 庆祝神经内分泌学诞生 60 周年

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2024-04-01 Epub Date: 2024-04-10 DOI: 10.1016/j.yfrne.2024.101134

Liisa A.M. Galea

引用次数: 0