Frontiers in Neuroendocrinology最新文献_第7页

Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies 异位脂肪对大脑结构和认知功能的影响:观察性研究的系统回顾和荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101082

Zhi-Hui Song , Jing Liu , Xiao-Feng Wang , Rafael Simó , Chao Zhang , Jian-Bo Zhou

{"title":"Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies","authors":"Zhi-Hui Song , Jing Liu , Xiao-Feng Wang , Rafael Simó , Chao Zhang , Jian-Bo Zhou","doi":"10.1016/j.yfrne.2023.101082","DOIUrl":"10.1016/j.yfrne.2023.101082","url":null,"abstract":"<div><p>Ectopic fat, defined as a specific organ or compartment with the accumulation of fat tissue surrounding organs, is highly associated with obesity which has been identified as a risk factor for cognitive impairment and dementia. However, the relationship between ectopic fat and changes in brain structure or cognition is yet to be elucidated. Here, we investigated the effects of ectopic fat on brain structure and cognitive function via systemic review and meta-analysis. A total of 21 studies were included from electronic databases up to July 9, 2022.</p><p>We found ectopic fat was associated with decreased total brain volumeand increased lateral ventricle volume. In addition, ectopic was associated with decreased cognitive scores and negatively correlated with cognitive function. More specifically, dementia development were correlated with increased levels of visceral fat. Overall, our data suggested that increased ectopic fat was associated with prominent structural changes in the brain and cognitive decline, an effect driven mainly by increases in visceral fat, while subcutaneous fat may be protective. Our results suggest that patients with increased visceral fat are at risk of developing cognitive impairment and, therefore, represent a subset of population in whom appropriate and timely preventive measures could be implemented.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101082"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging 心脏代谢健康、绝经期雌激素治疗和大脑:雌激素在健康和不健康的衰老临床前模型中的作用是如何不同的

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101068

Jill M. Daniel , Sarah H. Lindsey , Ricardo Mostany , Laura A. Schrader , Andrea Zsombok

{"title":"Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging","authors":"Jill M. Daniel , Sarah H. Lindsey , Ricardo Mostany , Laura A. Schrader , Andrea Zsombok","doi":"10.1016/j.yfrne.2023.101068","DOIUrl":"10.1016/j.yfrne.2023.101068","url":null,"abstract":"<div><p>Research in preclinical models indicates that estrogens are neuroprotective and positively impact cognitive aging. However, clinical data are equivocal as to the benefits of menopausal estrogen therapy to the brain and cognition. Pre-existing cardiometabolic disease may modulate mechanisms by which estrogens act, potentially reducing or reversing protections they provide against cognitive decline. In the current review we propose mechanisms by which cardiometabolic disease may alter estrogen effects, including both alterations in actions directly on brain memory systems and actions on cardiometabolic systems, which in turn impact brain memory systems. Consideration of mechanisms by which estrogen administration can exert differential effects dependent upon health phenotype is consistent with the move towards precision or personalized medicine, which aims to determine which treatment interventions will work for which individuals. Understanding effects of estrogens in both healthy and unhealthy models of aging is critical to optimizing the translational link between preclinical and clinical research.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101068"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9940160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women’s use of alcohol: Neurobiobehavioral concomitants and consequences 女性饮酒:神经生物行为伴随物及其后果

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101079

Sara Jo Nixon , Christian C. Garcia , Ben Lewis

引用次数: 0

The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities 肠道微生物组在双相情感障碍及其常见医学合并症中的作用

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101078

Gregory H. Jones , Omar F. Pinjari , Courtney M. Vecera , Kacy Smith , Anita Barrera , Rodrigo Machado-Vieira

{"title":"The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities","authors":"Gregory H. Jones , Omar F. Pinjari , Courtney M. Vecera , Kacy Smith , Anita Barrera , Rodrigo Machado-Vieira","doi":"10.1016/j.yfrne.2023.101078","DOIUrl":"10.1016/j.yfrne.2023.101078","url":null,"abstract":"<div><p>Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this population. In that regard, gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory disorders. Microbial impact on immune, endocrine, endocannabinoid, kynurenine, and other pathways are discussed throughout this review. Emphasis is placed on this system’s relevance to current pharmacology, diet, and comorbid illness in bipolar disorder. Despite the high level of optimism promoted in many reviews on this topic, substantial obstacles exist before any microbiome-related findings can provide meaningful clinical utility. Beyond a comprehensive overview of pathophysiology, this review hopes to highlight several key areas where progress is needed. As well, novel microbiome-associated suggestions are presented for future research.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101078"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The historical progression of positron emission tomography research in neuroendocrinology 神经内分泌学正电子发射断层扫描研究的历史进展。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101081

Jason Bini

引用次数: 0

Neuroendocrine mechanisms contributing to the coevolution of sociality and communication 神经内分泌机制有助于社会性和沟通的共同进化。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101077

Megan K. Freiler, G. Troy Smith

{"title":"Neuroendocrine mechanisms contributing to the coevolution of sociality and communication","authors":"Megan K. Freiler, G. Troy Smith","doi":"10.1016/j.yfrne.2023.101077","DOIUrl":"10.1016/j.yfrne.2023.101077","url":null,"abstract":"<div><p>Communication is inherently social, so signaling systems should evolve with social systems. The ‘social complexity hypothesis’ posits that social complexity necessitates communicative complexity and is generally supported in vocalizing mammals. This hypothesis, however, has seldom been tested outside the acoustic modality, and comparisons across studies are confounded by varying definitions of complexity. Moreover, proximate mechanisms underlying coevolution of sociality and communication remain largely unexamined. In this review, we argue that to uncover how sociality and communication coevolve, we need to examine variation in the neuroendocrine mechanisms that coregulate social behavior and signal production and perception. Specifically, we focus on steroid hormones, monoamines, and nonapeptides, which modulate both social behavior and sensorimotor circuits and are likely targets of selection during social evolution. Lastly, we highlight weakly electric fishes as an ideal system in which to comparatively address the proximate mechanisms underlying relationships between social and signal diversity in a novel modality.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101077"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10306061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal contraception and cognition: Considering the influence of endogenous ovarian hormones and genes for clinical translation 激素避孕与认知:考虑卵巢内源性激素及基因的影响进行临床翻译

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101067

Laura Gravelsins , Sophia Zhao , Gillian Einstein

引用次数: 0

The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies 自闭症谱系障碍的神经胶质视角:来自死后脑和PET研究的证据

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101064

Xiaoli Liao , Miao Chen , Yamin Li

{"title":"The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies","authors":"Xiaoli Liao , Miao Chen , Yamin Li","doi":"10.1016/j.yfrne.2023.101064","DOIUrl":"10.1016/j.yfrne.2023.101064","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aimed to systematically and quantitatively review evidence derived from both postmortem brain and PET studies to explore the pathological role of glia induced neuroinflammation in the pathogenesis of ASD, and discuss the implications of these findings in relation to disease pathogenesis and therapeutic strategies.</p></div><div><h3>Method</h3><p>An online databases search was performed to collate postmortem studies and PET studies regarding glia induced neuroinflammation in ASD as compared to controls. Two authors independently conducted the literature search, study selection and data extraction. The discrepancies generated in these processes was resolved through robust discussions among all authors.</p></div><div><h3>Result</h3><p>The literature search yielded the identification of 619 records, from which 22 postmortem studies and 3 PET studies were identified as eligible for the qualitative synthesis. Meta-analysis of postmortem studies reported increased microglial number and microglia density as well as increased GFAP protein expression and GFAP mRNA expression in ASD subjects as compared to controls. Three PET studies produced different outcomes and emphasized different details, with one reported increased and two reported decreased TSPO expression in ASD subjects as compared to controls.</p></div><div><h3>Conclusion</h3><p>Both postmortem evidences and PET studies converged to support the involvement of glia induced neuroinflammation in the pathogenesis of ASD. The limited number of included studies along with the considerable heterogeneity of these studies prevented the development of firm conclusions and challenged the explanation of variability. Future research should prioritize the replication of current studies and the validation of current observations.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101064"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9969334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies 以食欲素/下丘脑泌素系统为靶点治疗神经精神和神经退行性疾病:从动物到临床研究

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101066

Marc Ten-Blanco , África Flores , Luigia Cristino , Inmaculada Pereda-Pérez , Fernando Berrendero

引用次数: 4

The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review 照顾慢性病儿童对HPA轴的影响:一项范围审查

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101062

Lindsey Mountcastle , Melissa Zajdel , Taylor Robinson , Krystyna R. Keller , Shani Gelles , Alicia A. Livinski , Bijal Kikani , Dawn E. Lea , Laura M. Koehly

{"title":"The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review","authors":"Lindsey Mountcastle , Melissa Zajdel , Taylor Robinson , Krystyna R. Keller , Shani Gelles , Alicia A. Livinski , Bijal Kikani , Dawn E. Lea , Laura M. Koehly","doi":"10.1016/j.yfrne.2023.101062","DOIUrl":"10.1016/j.yfrne.2023.101062","url":null,"abstract":"<div><p>Caregiving has been robustly linked to caregiver health through the dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis in the context of caregiving for an adult with a chronic illness. However, little research examines the physiological impact of caregiving for a child with a chronic illness despite high burden and unique stressors. In this review, we explore the links of caregiving for a child with a congenital, chromosomal, or genetic disorder to the regulation or dysregulation of the HPA axis. A search was conducted in PubMed, Embase, and the Web of Science and 15 studies met inclusion criteria. Overall, there were inconsistent links of caregiving to HPA axis functioning, perhaps due to the heterogeneity across disease contexts, study designs, and biomarker measurement. Future research should standardize measurement and study designs, increase participant diversity, and examine moderators of the links of caregiving to the HPA axis.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"69 ","pages":"Article 101062"},"PeriodicalIF":7.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0