Frontiers in Neuroendocrinology最新文献_第7页

Hormonal contraception and cognition: Considering the influence of endogenous ovarian hormones and genes for clinical translation 激素避孕与认知:考虑卵巢内源性激素及基因的影响进行临床翻译

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101067

Laura Gravelsins , Sophia Zhao , Gillian Einstein

引用次数: 0

The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies 自闭症谱系障碍的神经胶质视角:来自死后脑和PET研究的证据

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101064

Xiaoli Liao , Miao Chen , Yamin Li

{"title":"The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies","authors":"Xiaoli Liao , Miao Chen , Yamin Li","doi":"10.1016/j.yfrne.2023.101064","DOIUrl":"10.1016/j.yfrne.2023.101064","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aimed to systematically and quantitatively review evidence derived from both postmortem brain and PET studies to explore the pathological role of glia induced neuroinflammation in the pathogenesis of ASD, and discuss the implications of these findings in relation to disease pathogenesis and therapeutic strategies.</p></div><div><h3>Method</h3><p>An online databases search was performed to collate postmortem studies and PET studies regarding glia induced neuroinflammation in ASD as compared to controls. Two authors independently conducted the literature search, study selection and data extraction. The discrepancies generated in these processes was resolved through robust discussions among all authors.</p></div><div><h3>Result</h3><p>The literature search yielded the identification of 619 records, from which 22 postmortem studies and 3 PET studies were identified as eligible for the qualitative synthesis. Meta-analysis of postmortem studies reported increased microglial number and microglia density as well as increased GFAP protein expression and GFAP mRNA expression in ASD subjects as compared to controls. Three PET studies produced different outcomes and emphasized different details, with one reported increased and two reported decreased TSPO expression in ASD subjects as compared to controls.</p></div><div><h3>Conclusion</h3><p>Both postmortem evidences and PET studies converged to support the involvement of glia induced neuroinflammation in the pathogenesis of ASD. The limited number of included studies along with the considerable heterogeneity of these studies prevented the development of firm conclusions and challenged the explanation of variability. Future research should prioritize the replication of current studies and the validation of current observations.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101064"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9969334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies 以食欲素/下丘脑泌素系统为靶点治疗神经精神和神经退行性疾病:从动物到临床研究

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101066

Marc Ten-Blanco , África Flores , Luigia Cristino , Inmaculada Pereda-Pérez , Fernando Berrendero

引用次数: 4

The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review 照顾慢性病儿童对HPA轴的影响:一项范围审查

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101062

Lindsey Mountcastle , Melissa Zajdel , Taylor Robinson , Krystyna R. Keller , Shani Gelles , Alicia A. Livinski , Bijal Kikani , Dawn E. Lea , Laura M. Koehly

{"title":"The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review","authors":"Lindsey Mountcastle , Melissa Zajdel , Taylor Robinson , Krystyna R. Keller , Shani Gelles , Alicia A. Livinski , Bijal Kikani , Dawn E. Lea , Laura M. Koehly","doi":"10.1016/j.yfrne.2023.101062","DOIUrl":"10.1016/j.yfrne.2023.101062","url":null,"abstract":"<div><p>Caregiving has been robustly linked to caregiver health through the dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis in the context of caregiving for an adult with a chronic illness. However, little research examines the physiological impact of caregiving for a child with a chronic illness despite high burden and unique stressors. In this review, we explore the links of caregiving for a child with a congenital, chromosomal, or genetic disorder to the regulation or dysregulation of the HPA axis. A search was conducted in PubMed, Embase, and the Web of Science and 15 studies met inclusion criteria. Overall, there were inconsistent links of caregiving to HPA axis functioning, perhaps due to the heterogeneity across disease contexts, study designs, and biomarker measurement. Future research should standardize measurement and study designs, increase participant diversity, and examine moderators of the links of caregiving to the HPA axis.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"69 ","pages":"Article 101062"},"PeriodicalIF":7.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease 孤独和社会隔离对认知能力下降和阿尔茨海默病发展的影响

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101061

Yi Ren , Aisouda Savadlou , Soobin Park , Paul Siska , Jonathan R. Epp , Derya Sargin

引用次数: 9

Stress in adolescence as a first hit in stress-related disease development: Timing and context are crucial 青春期的压力是压力相关疾病发展的第一个打击:时间和环境至关重要

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101065

Giulia F. Mancini , Onno C. Meijer , Patrizia Campolongo

引用次数: 0

Progesterone and contraceptive progestin actions on the brain: A systematic review of animal studies and comparison to human neuroimaging studies 黄体酮和避孕黄体酮对大脑的作用:动物研究的系统回顾和与人类神经影像学研究的比较

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101060

Belinda Pletzer , Katharina Winkler-Crepaz , Katharina Maria Hillerer

{"title":"Progesterone and contraceptive progestin actions on the brain: A systematic review of animal studies and comparison to human neuroimaging studies","authors":"Belinda Pletzer , Katharina Winkler-Crepaz , Katharina Maria Hillerer","doi":"10.1016/j.yfrne.2023.101060","DOIUrl":"10.1016/j.yfrne.2023.101060","url":null,"abstract":"<div><p>In this review we systematically summarize the effects of progesterone and synthetic progestins on neurogenesis, synaptogenesis, myelination and six neurotransmitter systems. Several parallels between progesterone and older generation progestin actions emerged, suggesting actions via progesterone receptors. However, existing results suggest a general lack of knowledge regarding the effects of currently used progestins in hormonal contraception regarding these cellular and molecular brain parameters. Human neuroimaging studies were reviewed with a focus on randomized placebo-controlled trials and cross-sectional studies controlling for progestin type. The prefrontal cortex, amygdala, salience network and hippocampus were identified as regions of interest for future preclinical studies. This review proposes a series of experiments to elucidate the cellular and molecular actions of contraceptive progestins in these areas and link these actions to behavioral markers of emotional and cognitive functioning. Emotional effects of contraceptive progestins appear to be related to 1) alterations in the serotonergic system, 2) direct/indirect modulations of inhibitory GABA-ergic signalling via effects on the allopregnanolone content of the brain, which differ between androgenic and anti-androgenic progestins. Cognitive effects of combined oral contraceptives appear to depend on the ethinylestradiol dose.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"69 ","pages":"Article 101060"},"PeriodicalIF":7.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The importance of translationally evaluating steroid hormone contributions to substance use 翻译评估类固醇激素对物质使用贡献的重要性

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101059

Erin E. Maher , Ashley M. Strzelecki , Jessica J. Weafer , Cassandra D. Gipson

{"title":"The importance of translationally evaluating steroid hormone contributions to substance use","authors":"Erin E. Maher , Ashley M. Strzelecki , Jessica J. Weafer , Cassandra D. Gipson","doi":"10.1016/j.yfrne.2023.101059","DOIUrl":"10.1016/j.yfrne.2023.101059","url":null,"abstract":"<div><p>Clinically, women appear to be more susceptible to certain aspects of substance use disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have been linked to women-specific drug behaviors. Here, we review clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors. We also highlight gaps in the literature regarding how synthetic steroid hormone use may influence drug-related behaviors. In addition, we explore how E2 and Pg are known to interact in brain reward pathways and provide evidence of how these interactions may influence drug-related behaviors. The synthesis of this review demonstrates the critical need to study women-specific factors that may influence aspects of SUDs, which may play important roles in addiction processes in a sex-specific fashion. It is important to understand factors that impact women’s health and may be key to moving the field forward toward more efficacious and individualized treatment strategies.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"69 ","pages":"Article 101059"},"PeriodicalIF":7.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial overview: Hormonal contraceptives and the brain: A call for translational research 编辑概述:激素避孕药和大脑:对转化研究的呼吁

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2023.101063

Jesse M. Lacasse, Nafissa Ismail, Natalie C. Tronson

引用次数: 0

Oral contraceptives and cognition: A systematic review 口服避孕药与认知:系统综述

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI: 10.1016/j.yfrne.2022.101052

Caroline Gurvich, Isobel Nicholls, Alex Lavale, Jayashri Kulkarni

引用次数: 3