Frontiers in Neuroendocrinology最新文献

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Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review 对特里尔社会压力测试的生理和情绪反应的多系统评价:荟萃分析和系统回顾
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI: 10.1016/j.yfrne.2022.101050
Idy S.C. Man , Robin Shao , W.K. Hou , Shirley Xin Li , Fiona Yan Liu , Maggy Lee , Yun Kwok Wing , Suk-yu Yau , Tatia M.C. Lee
{"title":"Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review","authors":"Idy S.C. Man ,&nbsp;Robin Shao ,&nbsp;W.K. Hou ,&nbsp;Shirley Xin Li ,&nbsp;Fiona Yan Liu ,&nbsp;Maggy Lee ,&nbsp;Yun Kwok Wing ,&nbsp;Suk-yu Yau ,&nbsp;Tatia M.C. Lee","doi":"10.1016/j.yfrne.2022.101050","DOIUrl":"10.1016/j.yfrne.2022.101050","url":null,"abstract":"<div><p>Humans experience multiple biological and emotional changes under acute stress. Adopting a multi-systemic approach, we summarized 61 studies on healthy people’s endocrinological, physiological, immunological and emotional responses to the Trier Social Stress Test. We found salivary cortisol and negative mood states were the most sensitive markers to acute stress and recovery. Biomarkers such as heart rate and salivary alpha-amylase also showed sensitivity to acute stress, but the numbers of studies were small. Other endocrinological (e.g., dehydroepiandrosterone), inflammatory (C-Reactive Protein, Interleukin-6) and physiological (e.g., skin conductance level) measures received modest support as acute stress markers. Salivary cortisol showed some associations with mood measures (e.g., state anxiety) during acute stress and recovery, and heart rate showed preliminary positive relationship with calmness ratings during response to TSST, but the overall evidence was mixed. While further research is needed, these findings provide updated and comprehensive knowledge on the integrated psychobiological response profiles to TSST.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"68 ","pages":"Article 101050"},"PeriodicalIF":7.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Oral contraceptives in the central nervous system: Basic pharmacology, methodological considerations, and current state of the field 口服避孕药在中枢神经系统:基本药理学,方法学的考虑,和该领域的现状
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI: 10.1016/j.yfrne.2022.101040
Elizabeth Hampson
{"title":"Oral contraceptives in the central nervous system: Basic pharmacology, methodological considerations, and current state of the field","authors":"Elizabeth Hampson","doi":"10.1016/j.yfrne.2022.101040","DOIUrl":"10.1016/j.yfrne.2022.101040","url":null,"abstract":"<div><p>Millions of women around the world use combined oral contraceptives (OCs), yet surprisingly little is known about their central nervous system (CNS) effects. This article provides a short overview of the basic pharmacology of OCs, emphasizing features that may be relevant to understanding their effects in the CNS. Historical and recent findings from studies of cognitive function, mood, and negative affect (depressive changes under OC use) are then reviewed. We also present data from an archival dataset from our own laboratory in which we explore dysphoric changes in women using four generations of contraceptive progestins. Current data in the field are consistent with a modest effect of OC use on CNS variables, but conclusions based on current findings must be made very cautiously because of multiple methodological issues in many published studies to date, and inconsistencies in the findings. Directions for future research over the next 10 years are suggested. (150 words)</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"68 ","pages":"Article 101040"},"PeriodicalIF":7.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9295229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Estradiol and progesterone in female reward-learning, addiction, and therapeutic interventions 雌二醇和黄体酮在女性奖励学习、成瘾和治疗干预中的作用
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI: 10.1016/j.yfrne.2022.101043
Emily N. Hilz , Hongjoo J. Lee
{"title":"Estradiol and progesterone in female reward-learning, addiction, and therapeutic interventions","authors":"Emily N. Hilz ,&nbsp;Hongjoo J. Lee","doi":"10.1016/j.yfrne.2022.101043","DOIUrl":"10.1016/j.yfrne.2022.101043","url":null,"abstract":"<div><p>Sex steroid hormones like estradiol (E2) and progesterone (P4) guide the sexual organization and activation of the developing brain and control female reproductive behavior throughout the lifecycle; importantly, these hormones modulate functional activity of not just the endocrine system, but most of the nervous system including the brain reward system. The effects of E2 and P4 can be seen in the processing of and memory for rewarding stimuli and in the development of compulsive reward-seeking behaviors like those seen in substance use disorders. Women are at increased risk of developing substance use disorders; however, the origins of this sex difference are not well understood and therapeutic interventions targeting ovarian hormones have produced conflicting results. This article reviews the contribution of the E2 and P4 in females to functional modulation of the brain reward system, their possible roles in origins of addiction vulnerability, and the development and treatment of compulsive reward-seeking behaviors.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"68 ","pages":"Article 101043"},"PeriodicalIF":7.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9295731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Combined oral contraceptives and mental health: Are adolescence and the gut-brain axis the missing links? 联合口服避孕药和心理健康:青春期和肠脑轴是缺失的环节吗?
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI: 10.1016/j.yfrne.2022.101041
Sarah Kheloui , Andra Smith , Nafissa Ismail
{"title":"Combined oral contraceptives and mental health: Are adolescence and the gut-brain axis the missing links?","authors":"Sarah Kheloui ,&nbsp;Andra Smith ,&nbsp;Nafissa Ismail","doi":"10.1016/j.yfrne.2022.101041","DOIUrl":"10.1016/j.yfrne.2022.101041","url":null,"abstract":"<div><p>Combined oral contraceptives (containing synthetic forms of estradiol and progestins) are one of the most commonly used drugs among females. However, their effects on the gut-brain axis have not been investigated to a great extent despite clear evidence that suggest bi-directional interactions between the gut microbiome and endogenous sex hormones. Moreover, oral contraceptives are prescribed during adolescence, a critical period of development during which several brain structures and systems, such as hypothalamic-pituitary–gonadal axis, undergo maturation. Considering that oral contraceptives could impact the developing adolescent brain and that these effects may be mediated by the gut-brain axis, further research investigating the effects of oral contraceptives on the gut-brain axis is imperative. This article briefly reviews evidence from animal and human studies on the effects of combined oral contraceptives on the brain and the gut microbiota particularly during adolescence.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"68 ","pages":"Article 101041"},"PeriodicalIF":7.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10785716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Moving beyond the mean: Promising research pathways to support a precision medicine approach to hormonal contraception 超越平均值:有希望的研究途径,以支持精确医学方法激素避孕
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI: 10.1016/j.yfrne.2022.101042
Sarah E. Hill , Summer Mengelkoch
{"title":"Moving beyond the mean: Promising research pathways to support a precision medicine approach to hormonal contraception","authors":"Sarah E. Hill ,&nbsp;Summer Mengelkoch","doi":"10.1016/j.yfrne.2022.101042","DOIUrl":"10.1016/j.yfrne.2022.101042","url":null,"abstract":"<div><p>Women’s psychological and behavioral responses to hormonal contraceptive (HC) treatment can be highly variable. One of the great challenges to researchers seeking to improve the experiences of women who use HCs is to identify the sources of this variability to minimize unpleasant psychobehavioral side-effects. In the following, we provide recommendations for programs of research aimed at identifying sources of heterogeneity in women’s experiences with HC. First, we review research demonstrating person- and prescription- based heterogeneity in women’s psychobehavioral responses to HCs. Next, we identify several promising person- and prescription- based sources of this heterogeneity that warrant future research. We close with a discussion of research approaches that are particularly well-suited to address the research questions raised in article. Together, this review provides researchers with several promising research pathways to help support the development of a precision medicine approach to HC treatment.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"68 ","pages":"Article 101042"},"PeriodicalIF":7.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10725544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Hormonal contraceptives and the brain: A systematic review on 60 years of neuroimaging, EEG, and biochemical studies in humans and animals 激素避孕药与大脑:对60年来人类和动物神经成像、脑电图和生化研究的系统回顾
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2023-01-01 DOI: 10.1016/j.yfrne.2022.101051
Joan Y. Song , Caroline Delbourgo Patton , Renee Friedman , Lakshmi S. Mahajan , Rachel Nordlicht , Rahman Sayed , Michael L. Lipton
{"title":"Hormonal contraceptives and the brain: A systematic review on 60 years of neuroimaging, EEG, and biochemical studies in humans and animals","authors":"Joan Y. Song ,&nbsp;Caroline Delbourgo Patton ,&nbsp;Renee Friedman ,&nbsp;Lakshmi S. Mahajan ,&nbsp;Rachel Nordlicht ,&nbsp;Rahman Sayed ,&nbsp;Michael L. Lipton","doi":"10.1016/j.yfrne.2022.101051","DOIUrl":"10.1016/j.yfrne.2022.101051","url":null,"abstract":"<div><p>Hormonal contraception<span><span> has been widely prescribed for decades. Although safety and efficacy are well-established, much uncertainty remains regarding brain effects of hormonal contraception. We systematically review human and animal studies on the brain effects of hormonal contraception which employed neuroimaging techniques such as MRI, PET<span> and EEG<span>, as well as animal studies which reported on neurotransmitter and other brain biochemical effects. We screened 1001 articles and ultimately extracted data from 70, comprising 51 human and 19 animal studies. Of note, there were no animal studies which employed structural or functional MRI, </span></span></span>MRS or PET. In summary, our review shows hormonal contraceptive associations with changes in the brain have been documented. Many questions remain and more studies are needed to describe the effects of hormonal contraception on the brain.</span></p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"68 ","pages":"Article 101051"},"PeriodicalIF":7.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10786746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Appetite-regulating hormones in bipolar disorder: A systematic review and meta-analysis 食欲调节激素在双相情感障碍中的作用:系统回顾和荟萃分析
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2022-10-01 DOI: 10.1016/j.yfrne.2022.101013
Błażej Misiak , Krzysztof Kowalski , Bartłomiej Stańczykiewicz , Francesco Bartoli , Giuseppe Carrà , Jerzy Samochowiec , Agnieszka Samochowiec , Dorota Frydecka
{"title":"Appetite-regulating hormones in bipolar disorder: A systematic review and meta-analysis","authors":"Błażej Misiak ,&nbsp;Krzysztof Kowalski ,&nbsp;Bartłomiej Stańczykiewicz ,&nbsp;Francesco Bartoli ,&nbsp;Giuseppe Carrà ,&nbsp;Jerzy Samochowiec ,&nbsp;Agnieszka Samochowiec ,&nbsp;Dorota Frydecka","doi":"10.1016/j.yfrne.2022.101013","DOIUrl":"10.1016/j.yfrne.2022.101013","url":null,"abstract":"<div><p>Impaired hormonal regulation of appetite may contribute to higher cardiovascular risk in bipolar disorder (BD). We performed a systematic review and meta-analysis of studies investigating peripheral blood levels of appetite-regulating hormones in BD and controls. A total of 32 studies were included. Leptin and insulin levels were significantly elevated in patients with BD during euthymia, but not in other mood states. Greater differences in the number of male participants between patients with BD and healthy controls were associated with higher effect size estimates for the levels of insulin. There were significant positive correlations of effect size estimates for the levels of adiponectin with the percentage of individuals with type I BD and duration of BD. Our findings point to the mechanisms underlying high rates of cardiometabolic comorbidities in BD. Moreover, they suggest that investigating hormonal regulation of appetite might help to understand differences in the neurobiology of BD types.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"67 ","pages":"Article 101013"},"PeriodicalIF":7.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S009130222200036X/pdfft?md5=7bdbbc1879bc5cc4ed164ec00db12801&pid=1-s2.0-S009130222200036X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40475055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The critical impact of sex on preclinical alcohol research – Insights from zebrafish 性别对临床前酒精研究的关键影响——来自斑马鱼的见解
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2022-10-01 DOI: 10.1016/j.yfrne.2022.101014
Murilo S. de Abreu , Matthew O. Parker , Allan V. Kalueff
{"title":"The critical impact of sex on preclinical alcohol research – Insights from zebrafish","authors":"Murilo S. de Abreu ,&nbsp;Matthew O. Parker ,&nbsp;Allan V. Kalueff","doi":"10.1016/j.yfrne.2022.101014","DOIUrl":"10.1016/j.yfrne.2022.101014","url":null,"abstract":"<div><p>Sex is an important biological variable that is widely recognized in studies of alcohol-related effects. Complementing clinical and preclinical rodent research, the zebrafish (<em>Danio rerio</em>) is the second most used laboratory species, and a powerful model organism in biomedicine. Like clinical and rodent models, zebrafish demonstrate overt sex differences in alcohol-related responses. Collectively, this evidence shows that the zebrafish becomes a sensitive model species to further probe in-depth sex differences commonly reported in alcohol research.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"67 ","pages":"Article 101014"},"PeriodicalIF":7.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40579216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paroxetine combined with traditional chinese medicine prescriptions in the treatment of postpartum depression: A systematic review of randomized controlled trials 帕罗西汀联合中药方剂治疗产后抑郁症:随机对照试验的系统评价
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2022-10-01 DOI: 10.1016/j.yfrne.2022.101019
Mengjie Zeng , Aimin Gong , Zhiquan Wu
{"title":"Paroxetine combined with traditional chinese medicine prescriptions in the treatment of postpartum depression: A systematic review of randomized controlled trials","authors":"Mengjie Zeng ,&nbsp;Aimin Gong ,&nbsp;Zhiquan Wu","doi":"10.1016/j.yfrne.2022.101019","DOIUrl":"10.1016/j.yfrne.2022.101019","url":null,"abstract":"<div><h3>Background</h3><p>Postpartum depression is a common mental disease in obstetric puerperium. Its etiology is not completely clear, and its clinical manifestations are complex. It has serious adverse effects on the body and mind of mothers and infants. Treatment should also follow the principle of individualization. Preliminary studies have shown that traditional chinese medicine prescriptions combined with paroxetine is effective in treating postpartum depression. In order to better determine the therapeutic effect, further exploration was carried out.</p></div><div><h3>Hypothesis</h3><p>Does the study better evaluate the therapeutic effect and provide data support for clinical promotion?</p></div><div><h3>Study Design</h3><p>The search comes from using the following electronic databases established until January 2022.</p></div><div><h3>Study Results</h3><p>The meta analysis results show that paroxetine combined with traditional chinese medicine prescriptions can reduce the Hamilton Depression Scale (HAMD) score [WMD = −7.35, 95 % CI (−10.84, −3.87), P<0.001] and Edinburgh Postpartum Depression Scale (EPDS) score [WMD = −3.24, 95 % CI (−5.96, −0.53), P &lt; 0.001].And better than paroxetine treatment alone in terms of improving clinical efficacy [RR = 1.22, 95 % CI (1.16, 1.30), P &lt; 0.001].</p></div><div><h3>Conclusions</h3><p>Based on the combination of paroxetine and traditional chinese medicine prescriptions in the treatment of postpartum depression, there is a certain clinical effect, and a strong research design and a certain number of RCTs are required at the same time. Future research should clarify the specific composition and composition of traditional Chinese medicine prescriptions.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"67 ","pages":"Article 101019"},"PeriodicalIF":7.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0091302222000425/pdfft?md5=ec9037ff98a56ddfc5604b035423cf15&pid=1-s2.0-S0091302222000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Combined oral contraceptive use and risk for binge eating in women: Potential gene × hormone interactions 联合使用口服避孕药与女性暴食的风险:潜在的基因与激素的相互作用
IF 7.4 1区 医学
Frontiers in Neuroendocrinology Pub Date : 2022-10-01 DOI: 10.1016/j.yfrne.2022.101039
Kelly L. Klump , Alaina M. Di Dio
{"title":"Combined oral contraceptive use and risk for binge eating in women: Potential gene × hormone interactions","authors":"Kelly L. Klump ,&nbsp;Alaina M. Di Dio","doi":"10.1016/j.yfrne.2022.101039","DOIUrl":"10.1016/j.yfrne.2022.101039","url":null,"abstract":"<div><p>Extant animal and human data suggest endogenous ovarian hormones increase risk for binge eating in females, possibly via gene × hormone interactions and hormonally induced increases in genetic influences. Approximately 85 % of women will take combined oral contraceptives (COCs) that mimic the riskiest hormonal milieu for binge eating (i.e., post-ovulation when both estrogen and progesterone are present). The purpose of this narrative review is to synthesize findings of binge eating risk in COC users. Few studies have been conducted, but results suggest that COCs may increase risk for binge eating and related phenotypes (e.g., craving for sweets), particularly in genetically vulnerable women. Larger, more systematic human and animal studies of COCs and binge eating are needed. The goal of this work should be to advance personalized medicine by identifying the extent of COC risk as well as the role of gene × hormone interactions in susceptibility.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"67 ","pages":"Article 101039"},"PeriodicalIF":7.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40386416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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