Frontiers in Neuroendocrinology最新文献_第8页

Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research 神经系统疾病与生殖内分泌功能障碍的联系机制:来自癫痫研究的见解

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-10-01 DOI: 10.1016/j.yfrne.2023.101084

Cathryn A. Cutia , Catherine A. Christian-Hinman

{"title":"Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research","authors":"Cathryn A. Cutia , Catherine A. Christian-Hinman","doi":"10.1016/j.yfrne.2023.101084","DOIUrl":"10.1016/j.yfrne.2023.101084","url":null,"abstract":"<div><p>Gonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary–gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from temporal lobe structures, can drive HPG axis alterations, and hormones produced in the HPG axis can reciprocally modulate seizure activity. Despite this relationship, mechanistic links between seizures and RED, and vice versa, are still largely unknown. Here, we review clinical evidence alongside recent investigations in preclinical animal models into the contributions of seizures to HPG axis malfunction, describe the effects of HPG axis hormonal feedback on seizure activity, and discuss how epilepsy research can offer insight into mechanisms linking neurological disorders to HPG axis dysfunction, an understudied area of neuroendocrinology.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"71 ","pages":"Article 101084"},"PeriodicalIF":7.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fast neurotransmitter identity of MCH neurons: Do contents depend on context? MCH神经元的快速神经递质识别:内容依赖于环境吗?

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101069

B.G. Beekly , A. Rupp , C.R. Burgess , C.F. Elias

引用次数: 0

Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies 社区居住成人维生素D状态和认知表现:观察性研究的剂量-反应荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101080

Janis D. Harse , Ross J. Marriott , Kun Zhu , Kevin Murray , Romola S. Bucks

{"title":"Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies","authors":"Janis D. Harse , Ross J. Marriott , Kun Zhu , Kevin Murray , Romola S. Bucks","doi":"10.1016/j.yfrne.2023.101080","DOIUrl":"10.1016/j.yfrne.2023.101080","url":null,"abstract":"<div><p>Low vitamin D status is linked with poorer cognition in adults while findings in relation to high levels are mixed.We performed a systematic review and <em>meta</em>-analyses to examine dose–response associations between 25-hydroxyvitamin D (25OHD) levelsand cognitive performance in community-dwelling adults. Thirty-eight observational studies were included in dose–response <em>meta</em>-analyses. Positive, nonlinear associations were identified between baseline25OHD levels and global cognition incross-sectional and longitudinal analyses, and for performance in memory and executive function in longitudinal analyses. When restricted to studies involving older adults, thepattern emerged forspecific domains in cross-sectional analyses. Poorer performance was associated with low 25OHD levels, while a sharp improvement was associated withlevels up to 60–70 nM/L. Further improvement was observed only for longitudinal global cognition. Our findings support the association between low vitamin D and poorer cognition and suggest levels of at least 60 nM/L are associated with better cognition during ageing.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101080"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9946457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies 异位脂肪对大脑结构和认知功能的影响:观察性研究的系统回顾和荟萃分析

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101082

Zhi-Hui Song , Jing Liu , Xiao-Feng Wang , Rafael Simó , Chao Zhang , Jian-Bo Zhou

{"title":"Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies","authors":"Zhi-Hui Song , Jing Liu , Xiao-Feng Wang , Rafael Simó , Chao Zhang , Jian-Bo Zhou","doi":"10.1016/j.yfrne.2023.101082","DOIUrl":"10.1016/j.yfrne.2023.101082","url":null,"abstract":"<div><p>Ectopic fat, defined as a specific organ or compartment with the accumulation of fat tissue surrounding organs, is highly associated with obesity which has been identified as a risk factor for cognitive impairment and dementia. However, the relationship between ectopic fat and changes in brain structure or cognition is yet to be elucidated. Here, we investigated the effects of ectopic fat on brain structure and cognitive function via systemic review and meta-analysis. A total of 21 studies were included from electronic databases up to July 9, 2022.</p><p>We found ectopic fat was associated with decreased total brain volumeand increased lateral ventricle volume. In addition, ectopic was associated with decreased cognitive scores and negatively correlated with cognitive function. More specifically, dementia development were correlated with increased levels of visceral fat. Overall, our data suggested that increased ectopic fat was associated with prominent structural changes in the brain and cognitive decline, an effect driven mainly by increases in visceral fat, while subcutaneous fat may be protective. Our results suggest that patients with increased visceral fat are at risk of developing cognitive impairment and, therefore, represent a subset of population in whom appropriate and timely preventive measures could be implemented.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101082"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women are taking the hit: Examining the unique consequences of cannabis use across the female lifespan 女性正在遭受打击:研究大麻使用在女性生命周期中的独特后果

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101076

E.L. Gräfe , H.M.O. Reid , I. Shkolnikov , K. Conway , A. Kit , C. Acosta , B.R. Christie

引用次数: 2

Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging 心脏代谢健康、绝经期雌激素治疗和大脑:雌激素在健康和不健康的衰老临床前模型中的作用是如何不同的

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101068

Jill M. Daniel , Sarah H. Lindsey , Ricardo Mostany , Laura A. Schrader , Andrea Zsombok

{"title":"Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging","authors":"Jill M. Daniel , Sarah H. Lindsey , Ricardo Mostany , Laura A. Schrader , Andrea Zsombok","doi":"10.1016/j.yfrne.2023.101068","DOIUrl":"10.1016/j.yfrne.2023.101068","url":null,"abstract":"<div><p>Research in preclinical models indicates that estrogens are neuroprotective and positively impact cognitive aging. However, clinical data are equivocal as to the benefits of menopausal estrogen therapy to the brain and cognition. Pre-existing cardiometabolic disease may modulate mechanisms by which estrogens act, potentially reducing or reversing protections they provide against cognitive decline. In the current review we propose mechanisms by which cardiometabolic disease may alter estrogen effects, including both alterations in actions directly on brain memory systems and actions on cardiometabolic systems, which in turn impact brain memory systems. Consideration of mechanisms by which estrogen administration can exert differential effects dependent upon health phenotype is consistent with the move towards precision or personalized medicine, which aims to determine which treatment interventions will work for which individuals. Understanding effects of estrogens in both healthy and unhealthy models of aging is critical to optimizing the translational link between preclinical and clinical research.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101068"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9940160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women’s use of alcohol: Neurobiobehavioral concomitants and consequences 女性饮酒:神经生物行为伴随物及其后果

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101079

Sara Jo Nixon , Christian C. Garcia , Ben Lewis

引用次数: 0

The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities 肠道微生物组在双相情感障碍及其常见医学合并症中的作用

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101078

Gregory H. Jones , Omar F. Pinjari , Courtney M. Vecera , Kacy Smith , Anita Barrera , Rodrigo Machado-Vieira

{"title":"The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities","authors":"Gregory H. Jones , Omar F. Pinjari , Courtney M. Vecera , Kacy Smith , Anita Barrera , Rodrigo Machado-Vieira","doi":"10.1016/j.yfrne.2023.101078","DOIUrl":"10.1016/j.yfrne.2023.101078","url":null,"abstract":"<div><p>Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this population. In that regard, gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory disorders. Microbial impact on immune, endocrine, endocannabinoid, kynurenine, and other pathways are discussed throughout this review. Emphasis is placed on this system’s relevance to current pharmacology, diet, and comorbid illness in bipolar disorder. Despite the high level of optimism promoted in many reviews on this topic, substantial obstacles exist before any microbiome-related findings can provide meaningful clinical utility. Beyond a comprehensive overview of pathophysiology, this review hopes to highlight several key areas where progress is needed. As well, novel microbiome-associated suggestions are presented for future research.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101078"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The historical progression of positron emission tomography research in neuroendocrinology 神经内分泌学正电子发射断层扫描研究的历史进展。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101081

Jason Bini

引用次数: 0

Neuroendocrine mechanisms contributing to the coevolution of sociality and communication 神经内分泌机制有助于社会性和沟通的共同进化。

IF 7.4 1区医学

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI: 10.1016/j.yfrne.2023.101077

Megan K. Freiler, G. Troy Smith

{"title":"Neuroendocrine mechanisms contributing to the coevolution of sociality and communication","authors":"Megan K. Freiler, G. Troy Smith","doi":"10.1016/j.yfrne.2023.101077","DOIUrl":"10.1016/j.yfrne.2023.101077","url":null,"abstract":"<div><p>Communication is inherently social, so signaling systems should evolve with social systems. The ‘social complexity hypothesis’ posits that social complexity necessitates communicative complexity and is generally supported in vocalizing mammals. This hypothesis, however, has seldom been tested outside the acoustic modality, and comparisons across studies are confounded by varying definitions of complexity. Moreover, proximate mechanisms underlying coevolution of sociality and communication remain largely unexamined. In this review, we argue that to uncover how sociality and communication coevolve, we need to examine variation in the neuroendocrine mechanisms that coregulate social behavior and signal production and perception. Specifically, we focus on steroid hormones, monoamines, and nonapeptides, which modulate both social behavior and sensorimotor circuits and are likely targets of selection during social evolution. Lastly, we highlight weakly electric fishes as an ideal system in which to comparatively address the proximate mechanisms underlying relationships between social and signal diversity in a novel modality.</p></div>","PeriodicalId":12469,"journal":{"name":"Frontiers in Neuroendocrinology","volume":"70 ","pages":"Article 101077"},"PeriodicalIF":7.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10306061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0