Liang Chu, Han Wang, Tao Ling, Shuhan Feng, Yucheng Ding, Yan Zhang, Ying Pan, Cenzhu Wang, Xiaohong Wang, Lei Liu
{"title":"Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma.","authors":"Liang Chu, Han Wang, Tao Ling, Shuhan Feng, Yucheng Ding, Yan Zhang, Ying Pan, Cenzhu Wang, Xiaohong Wang, Lei Liu","doi":"10.3389/fmolb.2025.1617787","DOIUrl":"10.3389/fmolb.2025.1617787","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the prognostic significance of positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal signet-ring cell carcinoma (SRCC).</p><p><strong>Methods: </strong>A multicenter retrospective cohort analysis was conducted involving 677 patients with advanced colorectal SRCC. The associations of variables with CSS and OS were analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards models. A nomogram model was developed to predict outcomes.</p><p><strong>Results: </strong>High-LNR, TD-positive, and PNI-positive were associated with poorer CSS and OS in both the training and validation cohorts. Multivariate Cox analysis identified T stage, M stage, TD, CEA, chemotherapy, and LNR as independent prognostic factors. A prognostic nomogram model incorporating these variables demonstrated excellent calibration and satisfactory predictive accuracy. Survival curves generated from individualized nomogram scores effectively discriminated prognostic outcomes (<i>P</i> < 0.001). The combined variable of LNR, TD, and PNI significantly enhanced the predictive performance. Specifically, the combined variable exhibited the highest relative contribution to OS at 23.4%, surpassing that of T and M stages. For CSS, its relative contribution was 21.4%, ranking second only to T and M stages.</p><p><strong>Conclusion: </strong>LNR, TD, and PNI served as prognostic factors for advanced colorectal SRCC. The combined analysis demonstrated a higher prognostic predictive value.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1617787"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arfs on the Golgi: four conductors, one orchestra.","authors":"Selma Yilmaz Dejgaard, John F Presley","doi":"10.3389/fmolb.2025.1612531","DOIUrl":"10.3389/fmolb.2025.1612531","url":null,"abstract":"<p><p>Arfs are small Ras-superfamily proteins important for regulating membrane trafficking including the recruitment of vesicular coats as well as a diverse range of other functions. There are five Arfs in humans: two Class I Arfs (Arf1 and Arf3), two Class II Arfs (Arf4 and Arf5) and one Class III Arf (Arf6), with Class I and Class II Arfs present on the Golgi apparatus among other locations. These Golgi Arfs (Arf1, Arf3, Arf4 and Arf5) are highly similar in sequence, and knockout studies have established a complex pattern of redundancy, with Arf4 alone able to support cell survival in tissue culture. Moreover, adding to the complexity, functions of Arfs on distinct membranes can involve non-overlapping sets of effectors (e.g., COPI on <i>cis</i>-Golgi membranes and clathrin adaptors on <i>trans</i>-Golgi network). The three classes of Arfs are found in most metazoans, suggesting biologically important specialization the details of which are beginning to emerge. This review examines recent studies using siRNA and CRISPR/Cas9 knockouts of mammalian Arfs combined with functional assays of the secretory pathway in the context of detailed localization of fluorescently-tagged Arfs by fluorescent and super-resolution microscopy and the existing literature using more conventional techniques. We suggest that specificity of effector recruitment involves additional membrane determinants which need to be considered in future studies.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1612531"},"PeriodicalIF":3.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuan Liu, Wei Du, Haibao Tang, Yingjian Gu, Zhibang Li, Xiaoyang Fu
{"title":"DFusMol: predicting molecular properties based on dual-channel attention.","authors":"Xuan Liu, Wei Du, Haibao Tang, Yingjian Gu, Zhibang Li, Xiaoyang Fu","doi":"10.3389/fmolb.2025.1623620","DOIUrl":"10.3389/fmolb.2025.1623620","url":null,"abstract":"<p><p>Accurate molecular property prediction is fundamental to modern drug discovery and materials design. However, prevailing computational methods are often insufficient, as they rely on single-granularity structural representations that fail to capture the hierarchical complexity of molecular systems. To address this challenge, we propose a new approach to molecular representation learning that incorporates structural information across multiple scales. We design DFusMol (Dual Fusion with Global and Local Attention), a novel framework inspired by multi-modal learning. DFusMol employs graph encoders to capture features from both atomic-level molecular graphs and motif-level graphs derived from chemical rules. A customized global-local attention mechanism then blends these diverse features to build comprehensive molecular representations. Experiments on nine public benchmark datasets reveal that DFusMol delivers top-tier predictive performance across all tasks, outperforming state-of-the-art self-supervised learning models on six of them. By effectively integrating atomic- and motif-level information, DFusMol provides an innovative and efficient solution for molecular property prediction, enhancing representation learning methodologies and demonstrating strong potential for applications in drug design and lead compound screening.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1623620"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huaxiu Zeng, Pooja Singh, Rajesh Sinha, Crystal T Stephens, Aftab Ahmad, Mohammad Athar, Veena B Antony
{"title":"Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure.","authors":"Huaxiu Zeng, Pooja Singh, Rajesh Sinha, Crystal T Stephens, Aftab Ahmad, Mohammad Athar, Veena B Antony","doi":"10.3389/fmolb.2025.1644792","DOIUrl":"10.3389/fmolb.2025.1644792","url":null,"abstract":"<p><strong>Introduction: </strong>Arsenicals like lewisite are highly toxic vesicant chemical warfare agents that cause severe skin damage and systemic inflammation. Exposure activates cytokine release, leading to pulmonary injury, including edema, hemorrhage, and in severe cases, Bronchiolitis Obliterans Syndrome (BOS), marked by airway fibrosis and narrowing. The only approved treatment, British anti-lewisite (BAL), has limitations due to toxicity and field administration challenges. BRD4, a BET family protein, regulates inflammatory gene expression, and its inhibition has shown therapeutic potential. CPI-0610 (Pelabresib), a selective BRD4 inhibitor, is currently being explored for its anti-fibrotic and anti-inflammatory effects.</p><p><strong>Methods: </strong>In a murine model, we evaluated the therapeutic potential of CPI-0610 in mitigating lewisite-induced pulmonary damage. Mice were exposed to a single cutaneous dose of lewisite to induce systemic lung injury. Following exposure, one group of mice received CPI-0610 treatment, while a control group remained untreated. Lung tissues were harvested for molecular and histological analysis. The expression of inflammatory and fibrotic markers, including interleukin-6 (IL-6) and alpha-smooth muscle actin (α-SMA), was quantified via RT-PCR and immunohistochemistry.</p><p><strong>Results: </strong>Treatment with CPI-0610 significantly reduced the expression of IL-6 and α-SMA in lung tissues of lewisite-exposed mice compared to untreated controls. Histological analysis revealed reduced signs of inflammation, extracellular matrix deposition, and fibrotic remodeling in the CPI-0610 group. These findings indicate a protective effect of BRD4 inhibition on arsenical-induced lung injury.</p><p><strong>Discussion: </strong>Our study provides the first experimental evidence that BRD4 inhibition via CPI-0610 attenuates the development of pulmonary fibrosis following cutaneous lewisite exposure in mice. These results suggest that targeting BRD4 signaling can effectively reduce inflammation and fibrotic progression in the lungs. Given CPI-0610's favorable clinical safety profile, it holds promise as a novel therapeutic strategy for treating arsenical-induced pulmonary complications, potentially improving outcomes where current countermeasures like BAL fall short. Further studies are warranted to explore its mechanism of action and therapeutic efficacy in broader exposure models.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1644792"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tools to study microbial iron homeostasis and oxidative stress: current techniques and methodological gaps.","authors":"Patryk Strzelecki, Dariusz Nowicki","doi":"10.3389/fmolb.2025.1628725","DOIUrl":"10.3389/fmolb.2025.1628725","url":null,"abstract":"<p><p>Iron is a vital nutrient for both microbial pathogens and their eukaryotic hosts, playing essential roles in stress adaptation, symbiotic interactions, virulence expression, and chronic inflammatory diseases. This review discusses current laboratory methods for iron detection and quantification in microbial cultures, host-pathogen models, and environmental samples. Microbial pathogens have evolved sophisticated specialized transport systems, iron acquisition strategies to overcome its limitation, including siderophore production, uptake of heme and host iron-binding. These iron-scavenging systems are closely linked to the regulation of virulence traits such as adhesion, motility, toxin secretion, and biofilm formation. In ESKAPEE pathogens (<i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, <i>Enterobacter</i> spp. and <i>Escherichia coli</i>), iron limitation enhances biofilm development, which protects bacteria from antibiotics and immune responses and promotes persistent infections. Even worse, pathogens can also manipulate host iron metabolism, exacerbating inflammation and disease progression. Although iron is indispensable for microbial growth, excessive intracellular iron promotes reactive oxygen species generation, causing oxidative damage and ferroptosis-like cell death. Understanding the dual role of iron as both a nutrient and a toxic agent highlights its importance in infection dynamics. We provide a critical overview of existing analytical techniques and emphasize the need for careful selection of methods to improve our understanding of microbial iron metabolism, host-pathogen interactions, and to support the development of new therapeutic and environmental monitoring strategies.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1628725"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation.","authors":"Xicheng Hu, Zhen Wang, Liyan Zhang","doi":"10.3389/fmolb.2025.1647796","DOIUrl":"10.3389/fmolb.2025.1647796","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Nephropathy (DN), a major microvascular complication of diabetes, poses challenges for current treatments to effectively delay its progression. Wulingsan (WLS), a traditional Chinese medicine formula, possesses potential for regulating water-fluid metabolism, and exhibits anti-inflammatory and antioxidant properties, yet its multi-target mechanism in treating DN remains unclear. This study aims to systematically elucidate the molecular mechanisms of WLS in the treatment of DN through network pharmacology, molecular docking, and <i>in vitro</i> experiments.</p><p><strong>Methods: </strong>Active ingredients of WLS and their targets were screened using the TCMSP database, while DN-related targets were obtained from the GeneCards and OMIM databases to construct an \"ingredient-target-disease\" network. GO and KEGG pathway enrichment analyses were performed using DAVID to identify key biological processes and signaling pathways. A protein-protein interaction (PPI) network was constructed via the STRING database, and key targets were screened using the CytoHubba plugin. Subsequently, molecular docking and molecular dynamics simulations were conducted to validate the binding affinity and stability of active ingredients with key targets. <i>In vitro</i>, a high glucose-induced HK-2 cell model was employed, and the effects of WLS on cell viability and cell cycle were assessed using CCK-8 assays and flow cytometry, respectively.</p><p><strong>Results: </strong>The study screened and identified SRC, AKT1, TNF, ESR1, and HSP90AA1 as key targets for the treatment of DN. KEGG enrichment analysis revealed that WLS primarily regulates signaling pathways such as PI3K-Akt and MAPK, which are closely associated with inflammation, oxidative stress, and fibrosis. Molecular docking indicated that active ingredients (β-caryophyllene, alisol C) exhibited binding energies below -5.0 kcal/mol with key targets (TNF, HSP90AA1), and molecular dynamics simulations further validated their binding stability. <i>In vitro</i> experiments demonstrated that WLS significantly inhibited the proliferation of high glucose-induced HK-2 cells (P < 0.01) and induced G2/M phase cell cycle arrest (P < 0.01).</p><p><strong>Conclusion: </strong>Wulingsan alleviates the progression of Diabetic Nephropathy by its multiple active ingredients acting synergistically on key targets such as SRC, AKT1, and TNF, thereby regulating PI3K-Akt and MAPK signaling pathways to inhibit inflammation, oxidative stress, and fibrosis. This research provides a theoretical basis for the clinical application of WLS, and its therapeutic efficacy warrants further verification through future <i>in vivo</i> experiments.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1647796"},"PeriodicalIF":3.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabel S Naarmann-De Vries, Tim Preissendörfer, Julian König, Christoph Dieterich
{"title":"<i>Ava</i>II senses m<sup>6</sup>A and inosine sites and enables targeted nanopore direct RNA-sequencing.","authors":"Isabel S Naarmann-De Vries, Tim Preissendörfer, Julian König, Christoph Dieterich","doi":"10.3389/fmolb.2025.1593637","DOIUrl":"10.3389/fmolb.2025.1593637","url":null,"abstract":"<p><p>Nanopore direct RNA-sequencing is the first commercialized method to sequence native RNA directly, thus preserving RNA modifications. With the current technology, sequencing is initiated from the 3'end. While for relatively short polyadenylated RNAs, full coverage is obtained, the 5'end of many long RNAs is not sufficiently covered resulting in a substantial 3'bias. We aimed to cleave such RNAs in a sequence-specific manner in order to generate new unique 3'ends that can be targeted by custom adapters. We identified the DNA endonuclease <i>Ava</i>II as a candidate enzyme. <i>Ava</i>II was originally described to cleave double-stranded DNA at GGWCC sites, where W is an A or T. Here, we show that <i>Ava</i>II cleaves also long RNAs in GGACC contexts, if hybridized to a complementary DNA oligo. Furthermore, we provide evidence that <i>Ava</i>II cleavage of RNA is modification sensitive and does not cleave RNA with m<sup>6</sup>A or inosine in the central position. We propose <i>Ava</i>II as \"methylation sensor\" for the <i>bona fide</i> DRACH recognition motif GGACC of the m<sup>6</sup>A writer complex. Finally, we show that <i>Ava</i>II cleavage products are accessible to targeted Nanopore direct RNA-sequencing.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1593637"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Chen, Lili Fu, Mengjin Li, Kun Xie, Xinming Li, Xu-Jie Zhou, Li Yang, Liming Zhang, Cheng Xue, Zhiguo Mao
{"title":"Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.","authors":"Juan Chen, Lili Fu, Mengjin Li, Kun Xie, Xinming Li, Xu-Jie Zhou, Li Yang, Liming Zhang, Cheng Xue, Zhiguo Mao","doi":"10.3389/fmolb.2025.1627534","DOIUrl":"10.3389/fmolb.2025.1627534","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a progressive disorder characterized by declining renal function and systemic metabolic disturbances. Brain-derived neurotrophic factor (BDNF), a key member of the neurotrophic family, plays critical roles in neuronal function and muscular metabolism. However, the evidence and regulatory mechanisms underlying decreased BDNF levels in CKD remain inconclusive.</p><p><strong>Methods: </strong>This study systematically evaluated circulating BDNF alterations in CKD patients through a meta-analysis of clinical studies involving 1,549 participants, complemented by experimental validation in unilateral ureteral obstruction (UUO) mice and single-cell transcriptomic database analysis to investigate tissue-specific BDNF protein expression and regulatory patterns.</p><p><strong>Results: </strong>Meta-analysis confirmed significantly reduced circulating BDNF in CKD patients (WMD = -0.62 ng/mL, 95% CI [-0.98, -0.25], <i>P</i> < 0.001; <i>I</i> <sup><i>2</i></sup> = 87%). In 14-day UUO mice, renal immunohistochemistry (IHC) showed significantly reduced BDNF expression (<i>P</i> < 0.001), which was further validated by Western blot analysis demonstrating a progressive decline in BDNF protein levels from day 14 to day 21 post-obstruction. Single-cell mRNA sequencing further confirmed that <i>Bdnf</i> levels were lower in renal proximal tubule (PT) cells, macrophages (Mφ), and podocytes in UUO mice compared to normal controls, Additionally, <i>Bdnf-as</i>-a long non-coding RNA known to epigenetically repress BDNF-was significantly upregulated in proximal tubules of CKD patients based on human transcriptomic data. This upregulation was validated in UUO mice by qPCR, showing a time-dependent increase in <i>Bdnf-as</i> expression at days 14 and 18 post-obstruction.</p><p><strong>Conclusion: </strong>This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA <i>Bdnf-as</i>.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1627534"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immune surveillance as a pharmacological target in the early stages of cancer.","authors":"Hongfei Jiang, Zhun Wei, Haibo Zhao","doi":"10.3389/fmolb.2025.1643024","DOIUrl":"10.3389/fmolb.2025.1643024","url":null,"abstract":"","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1643024"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Neural stem cell-derived extracellular vesicles: mini players with key roles in neurogenesis, immunomodulation, neuroprotection and aging.","authors":"Valentina Bonetto, Mariagrazia Grilli","doi":"10.3389/fmolb.2025.1667664","DOIUrl":"https://doi.org/10.3389/fmolb.2025.1667664","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmolb.2023.1187263.].</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1667664"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}