Frontiers in Molecular Biosciences最新文献

{"title":"Targeting ferroptosis and mitochondrial ROS: organoprotective mechanisms of anesthetic conditioning in liver transplantation.","authors":"Junming Li, Weijun Zeng, Juan Yang","doi":"10.3389/fmolb.2026.1901963","DOIUrl":"10.3389/fmolb.2026.1901963","url":null,"abstract":"<p><p>Liver transplantation is the definitive treatment for advanced liver failure, yet ischemia-reperfusion injury (IRI) remains a major challenge-particularly for marginal, steatotic, or donation-after-circulatory-death (DCD) grafts. While oxidative stress and inflammation are long-recognized contributors to IRI, this review focuses on two tightly linked, mechanistically specific pathways: ferroptosis and mitochondrial reactive oxygen species (ROS). Together, these pathways convert reperfusion-associated metabolic stress into injury of hepatocytes, endothelium, and bile ducts. Anesthetic preconditioning has gained interest as a modulator of this injury cascade. Volatile anesthetics, alongside propofol and dexmedetomidine, show experimental efficacy in reducing IRI by stabilizing mitochondria, regulating redox status, preserving GPX4(Glutathione Peroxidase 4)/SLC7A11(Solute Carrier Family 7 Member 11)-mediated antioxidant capacity, limiting lipid peroxidation, and dampening innate immune responses. However, clinical translation is limited by heterogeneity in experimental models, variability in anesthetic regimens, overreliance on non-specific oxidative stress markers, and a lack of validated ferroptosis-related endpoints in human studies. In summary, ferroptosis and mitochondrial ROS provide a cohesive mechanistic framework for graft vulnerability at reperfusion. To advance this field, future clinical studies should move beyond general oxidative stress assessments toward biomarker-driven approaches-integrating ferroptosis-specific markers and mitochondrial function tests. Coupling these with risk stratification of donor livers based on biochemical profiles, and tracking clinically meaningful outcomes, will enable precision strategies to mitigate IRI. This review underscores the need for targeted mechanistic validation to translate anesthetic conditioning into effective clinical organ protection.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1901963"},"PeriodicalIF":4.4,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA signatures in inflammatory dental tissues: biomarkers and molecular mechanisms.","authors":"Dandan Shao, Zhenyu Yao","doi":"10.3389/fmolb.2026.1881450","DOIUrl":"10.3389/fmolb.2026.1881450","url":null,"abstract":"<p><p>Inflammatory immune responses in the dental pulp are shaped by interacting cellular and molecular processes, and microRNAs (miRNAs) are important post-transcriptional regulators. However, an integrated understanding of how miRNA networks orchestrate the balance between pulpitis progression and tissue repair remains incomplete. This review examines the differential expression profiles of miRNAs in inflamed dental pulp, and evaluates their potential as adjunctive biomarkers of pulpitis status. We also summarize how miRNAs regulate key inflammatory signaling cascades, including the TLR/NF-κB, mitogen-activated protein kinase, and cGAS-STING pathways, and discuss their integration within broader epigenetic crosstalk networks involving lncRNAs and circRNAs. We further analyze how the inflammatory microenvironment and physicochemical stresses alter the osteogenic/odontogenic differentiation potential of dental pulp stem cells through miRNA-dependent regulation. We then assess the translational prospects of exosome-delivered miRNAs as cell-free therapeutics and highlight unresolved challenges in sampling feasibility, donor heterogeneity, delivery specificity, and clinical validation. By synthesizing evidence on miRNA regulatory networks in pulpal inflammation and regeneration, this review provides a framework for evaluating miRNA-based diagnostic tools and targeted therapies for pulpitis.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1881450"},"PeriodicalIF":4.4,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The function of phosphoglycerate mutase 1 (PGAM1) and its role in diseases.","authors":"Aihong Peng, Junqin Li, Huifang Liang, Yuanjun Yao, Kaiming Zhang","doi":"10.3389/fmolb.2026.1842545","DOIUrl":"10.3389/fmolb.2026.1842545","url":null,"abstract":"<p><p>Phosphoglycerate mutase 1 (PGAM1) is a pivotal metabolic enzyme during the process of glycolysis, catalyzing the interconversion between 3-phosphoglycerate and 2-phosphoglycerate. PGAM1 is mainly involved in cellular energy metabolism and biosynthesis, it is generally upregulated in numerous human cancers and promotes cell proliferation, invasion, and drug resistance. It serves as a significant biomarker for tumor diagnosis and a potential therapeutic target. In this paper, the basic structure and functions of PGAM1 and its family members, metabolic, non-metabolic activity and the regulatory mechanisms of PGAM1 and its correlation with diseases, as well as the latest progress of PGAM1 inhibitors in tumor diagnosis and treatment are introduced, aiming to provide new ideas for the targeted therapy of related diseases.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1842545"},"PeriodicalIF":4.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucosidase GANAB drives colorectal cancer progression through Wnt signaling and is modulated by lncRNA FIRRE.","authors":"Yajie Wang, Wenjun Li, Qian Hua, Zhengyang Li, Miao Jiang","doi":"10.3389/fmolb.2026.1820992","DOIUrl":"10.3389/fmolb.2026.1820992","url":null,"abstract":"<p><strong>Background: </strong>The goal of this study is to investigate the expression pattern of GANAB in colorectal cancer and the role behind it.</p><p><strong>Methods: </strong>In order to study the expression level of GANAB in the tissue of colorectal cancer, we used quantitative real-time PCR and immunohistochemistry. In the aspect of biological function, we study it through the experimental models. The molecular mechanism is clarified by RNA pull-down and RNA stability assays. Student's t-tests and one-way ANOVA are used for data analysis.</p><p><strong>Results: </strong>Analysis of tissue microarrays and Colorectal cancer (CRC) cell lines revealed elevated GANAB expression in tumors compared to normal counterparts. Increased GANAB levels were linked to enhanced cell migration, invasion, and proliferation, and correlated with metastatic potential and unfavorable patient outcomes. Functional enrichment studies indicated that GANAB-associated genes participate in the Wnt/β-catenin signaling pathway. Immunohistochemistry confirmed positive correlations between GANAB and both c-Myc and β-catenin. The oncogenic function of GANAB was shown to rely on Wnt pathway activation. Additionally, lncRNA FIRRE, known to be oncogenic in CRC, was found to physically interact with GANAB mRNA <i>via</i> RNA pull-down assays. FIRRE enhances GANAB mRNA stability through direct binding.</p><p><strong>Conclusion: </strong>Our study demonstrates that GANAB exerts oncogenic effects in CRC by binding directly to lncRNA FIRRE, thereby stabilizing GANAB mRNA and activating the Wnt/β-catenin pathway through nuclear accumulation of β-catenin.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1820992"},"PeriodicalIF":4.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Adoption of artificial intelligence in human and clinical genomics: volume II.","authors":"Li Zhang, Matteo Becatti","doi":"10.3389/fmolb.2026.1949944","DOIUrl":"https://doi.org/10.3389/fmolb.2026.1949944","url":null,"abstract":"","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1949944"},"PeriodicalIF":4.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular dynamics analysis of a docking-derived baicalein-PPARγ ligand-binding-domain model suggests a pocket-associated AF-2-anchor-silent ensemble.","authors":"Xingyuan Kou, Ping Wu, Zhuo Liu, Jing Yan, Le Li","doi":"10.3389/fmolb.2026.1870075","DOIUrl":"10.3389/fmolb.2026.1870075","url":null,"abstract":"<p><p>Baicalein was examined in a selected docking-derived peroxisome proliferator-activated receptor γ (PPARγ) ligand-binding-domain (LBD) model to test whether pocket association, local helix 12 (H12) organization, and canonical activation function-2 (AF-2) anchoring were coupled under the sampled simulation conditions. Because no baicalein-bound PPARγ cocrystal structure was used, the results are interpreted as a selected-pose molecular dynamics model rather than as a definitive experimental binding mode. Three independent 100-ns replicas were analyzed with bound-state filtering, H12 and AF-2 descriptors, arm-resolved energetic decomposition, interaction fingerprints, a local Tyr473-engagement potential of mean force (PMF), and exploratory state annotation. Baicalein remained spatially associated with the ligand-binding pocket by the minimum-distance and center-of-mass criteria, whereas pocket-shell contact persistence was replica-dependent, with retained fractions of 94.20%, 94.00%, and 71.64% in replicas 1-3. Within bound-state-filtered frames and under the selected neutral baicalein/HIE histidine model, direct ligand hydrogen bonds to Ser289, His323, His449, and Tyr473 were not detected, and the AF-2 anchor-panel union occupancy was 0.00%. This anchor-negative pattern occurred despite measurable local H12 order, indicating that local H12 structural persistence and canonical AF-2 anchor assembly were separable in the selected model. Arm-resolved molecular mechanics/generalized Born surface area (MM/GBSA) descriptors and ProLIF fingerprints supported mixed Arm II/Arm III participation, with recurrent van der Waals contacts involving Cys285, Ile341, Leu330, Leu333, Arg288, and Ile326. The local Tyr473 PMF favored a displaced baicalein geometry, with a minimum at 0.66 nm along the Tyr473 hydroxyl-to-ligand-acceptor coordinate. Limited ligand-protonation and His323/His449-tautomer sensitivity screens did not recover persistent canonical AF-2 anchoring under the tested short-screen conditions. Exploratory state analysis resolved in-pocket heterogeneity but did not identify a descriptor-supported state with persistent canonical AF-2 anchoring. These simulations support a constrained structural model in which baicalein samples a pocket-associated, measurably H12-organized, anchor-negative PPARγ ensemble stabilized by non-canonical pocket interactions. The interpretation is limited to simulation descriptors and does not establish receptor activation, partial agonism, phosphorylation regulation, or transcriptional output.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1870075"},"PeriodicalIF":4.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes with chronic intestinal pseudo-obstruction: a case-based review.","authors":"Lin Zhang, Junjian Lin, Fengying Li, Yujie Jia, Junhua Li, Xiaopeng Wang","doi":"10.3389/fmolb.2026.1857438","DOIUrl":"10.3389/fmolb.2026.1857438","url":null,"abstract":"<p><strong>Background: </strong>Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes (MELAS) is rare in people over 40 years of age, and gastrointestinal complications of MELAS are also rare, especially Chronic Intestinal Pseudo-Obstruction (CIPO).</p><p><strong>Case presentation: </strong>This report describes a 60 years old MELAS patient with a mutation rate of only 6.29% in the m.3243A>G gene, accompanied by CIPO. After treatment, MELAS symptoms can be controlled, but intestinal obstruction recurs and worsens. At present, patients fast and rely on intravenous nutrition to sustain their lives.</p><p><strong>Discussion: </strong>The low proportion of m.3243A>G mutations in patients may be related to their advanced age, but the high or low proportion of gene mutations detected in blood samples is not related to the severity of symptoms. MELAS combined with CIPO is rare and different from other intestinal obstructions. CIPO has no cause of mechanical intestinal obstruction and may be related to dysfunction of smooth muscle mitochondria or involvement of the enteric nervous system.</p><p><strong>Conclusion: </strong>For complications of MELAS beyond the nervous system, early consideration should be given to the possibility of MELAS. Early genetic testing has important clinical significance for the treatment and prognosis of patients. This article will provide a literature review on the multi system performance of MELAS.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1857438"},"PeriodicalIF":4.4,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of TMEM2-mediated hyaluronan degradation by CD44 and LYVE-1.","authors":"Yuki Tobisawa, Fumiakira Yano, Risa Tomioka-Inagawa, Fumitoshi Irie, Takuya Koie, Yu Yamaguchi","doi":"10.3389/fmolb.2026.1852012","DOIUrl":"10.3389/fmolb.2026.1852012","url":null,"abstract":"<p><p>Hyaluronan (HA) is a major glycosaminoglycan of the extracellular matrix that regulates cell migration, signaling, and tissue homeostasis. Its turnover is controlled by coordinated synthesis by HA synthases and degradation by hyaluronidases. Among these hyaluronidases, TMEM2, the only known transmembrane hyaluronidase, plays a unique role in HA degradation at the cell surface; however, the cellular conditions that support its activity remain incompletely understood. To address this, we developed a cell-based HA turnover assay to examine TMEM2-mediated degradation of endogenously synthesized HA, rather than exogenously added, fluorescently labeled HA used in previous studies. Using this system, we show that TMEM2 readily degrades high-molecular weight HA synthesized by co-expressed HAS3. This degradation occurs only when TMEM2 and HAS3 are co-expressed in the same cells (<i>cis</i>), whereas co-culture of TMEM2-expressing cells with HAS3-expressing cells supports little or no degradation. Interestingly, HA-binding cell surface receptors CD44 and its homolog LYVE-1 promote efficient TMEM2-mediated HA degradation even under <i>trans</i> conditions, whereas other HA-binding proteins, including TSG-6, layilin, TLR2, RHAMM, and ICAM-1, do not. These findings suggest a spatially regulated mechanism of TMEM2 activity in which capture of HA at the cell surface, mediated by CD44 or LYVE-1, contributes to efficient HA degradation by TMEM2.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1852012"},"PeriodicalIF":4.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148826549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamins and microelements levels and their association with children with attention deficit hyperactivity disorder (ADHD).","authors":"Tianzhu Chen, Jiaxiong Yao, Yang Su, Jingya Li, Panli Tan","doi":"10.3389/fmolb.2026.1786113","DOIUrl":"10.3389/fmolb.2026.1786113","url":null,"abstract":"<p><strong>Background: </strong>Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in children. The impact of environmental factors on ADHD is very important. Therefore, we analyzed and measured the correlation between the serum vitamin and microelement levels of Chinese children and the incidence rate of ADHD, hoping to provide some guidance for the prevention, diagnosis and treatment of ADHD.</p><p><strong>Methods: </strong>128 children (69 boys and 59 girls, with an average age of 9.38 ± 2.5 years) were diagnosed with ADHD. In addition, 133 healthy children were recruited as the healthy control group (HC). The levels of serum vitamins and elements were determined by liquid chromatography-mass spectrometry (LC-MS) and inductively coupled plasma mass spectrometry (ICP-MS). Use statistical analysis to compare the differences in the content of two groups of indicators and analyze their correlation with ADHD.</p><p><strong>Results: </strong>Compared with the healthy control group (HC group), children with ADHD exhibited significantly lower levels of serum vitamin A, vitamin D and vitamin D₃, while the levels of lead and copper were also significantly elevated. Logistic regression analysis indicated a negative correlation between vitamin D levels and ADHD.</p><p><strong>Conclusion: </strong>Children with ADHD exhibit significantly lower serum VD levels and higher Pb levels (only in boys), suggesting VD deficiency and sex-specific Pb susceptibility may be key factors associated with ADHD.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1786113"},"PeriodicalIF":4.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148826625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EMCN is associated with vascular-immune crosstalk and represents a potential biomarker in lung adenocarcinoma.","authors":"Yan Zhuang, Qingfeng Wang, Kaimin Wei, Fangjuan Wei, Xiaowei Yao, Yongliang Wang","doi":"10.3389/fmolb.2026.1752442","DOIUrl":"10.3389/fmolb.2026.1752442","url":null,"abstract":"<p><strong>Background: </strong>While MUC family genes have been established as prognostic biomarkers in gastric cancer, and GWAS studies link EMCN mutations to chemotherapy-induced myelosuppression in NSCLC, the systematic characterization of EMCN in lung adenocarcinoma (LUAD) remains elusive.</p><p><strong>Methods: </strong>This multi-omics strategy combining bulk and single-cell transcriptomics study integrated differential expression analysis, WGCNA, and machine learning algorithms (LASSO/SVM-RFE/Random Forest) to identify EMCN as a diagnostic hub gene, followed by experimental validation using immunohistochemistry Western blot and qRT-PCR.</p><p><strong>Results: </strong>EMCN (Endomucin) is a sialomucin-like glycoprotein predominantly expressed in vascular endothelial cells. Using bulk transcriptomic datasets and single-cell RNA-seq analysis, we found that EMCN expression was reduced in lung adenocarcinoma (LUAD) compared with non-tumor controls and was primarily localized to the endothelial compartment. Survival analysis using the median expression cutoff showed that high EMCN expression was associated with improved overall survival (Cox HR_high vs. low = 0.73, p = 0.04), indicating that low EMCN expression correlates with poorer prognosis. Machine learning-based feature selection (LASSO, Random Forest, and SVM) further prioritized EMCN among consensus candidate genes, supporting its potential relevance to the vascular-associated tumor microenvironment in LUAD. EMCN expression levels also showed a significant positive correlation with the degree of immune cell infiltration. Gene set enrichment analysis (GSEA) revealed that high EMCN expression in tumor tissues activates negative regulatory pathways associated with angiogenesis. Receiver operating characteristic (ROC) curve analysis highlights EMCN's excellent diagnostic potential for LUAD, with an area under the curve (AUC) of 0.963. <i>In vitro</i> experiments confirm the downregulation of EMCN at both protein and mRNA levels, consistent with our bioinformatics predictions.</p><p><strong>Conclusion: </strong>This first comprehensive study establishes EMCN as a dual-functional regulator of vascular-immune crosstalk in LUAD, providing both a molecular diagnostic tool and therapeutic target for precision oncology.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"13 ","pages":"1752442"},"PeriodicalIF":4.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148826526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}