American Journal of Medicine and Medical Sciences最新文献_第3页

Distance Mesuring of Physical Activity among Students and Workers of Moscow State University of Medicine and Dentistry 莫斯科国立医学和牙科大学学生和工作人员体育活动的距离测量

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120202.04

K. Gurevich, P. L. Salmanov, D. A. Pustovalov

引用次数: 0

Formulation and Optimization of Drug-Resin Complex Loaded Mucoadhesive Chitosan Beads of Repaglinide Using Factorial Design 瑞格列奈药-树脂复合物黏附壳聚糖微球的配方及优化

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120204.01

R. Ashwini, R. Mangesh, R. Rahul, S. Nilkanth, C. U. Devaki

{"title":"Formulation and Optimization of Drug-Resin Complex Loaded Mucoadhesive Chitosan Beads of Repaglinide Using Factorial Design","authors":"R. Ashwini, R. Mangesh, R. Rahul, S. Nilkanth, C. U. Devaki","doi":"10.5923/J.AJMMS.20120204.01","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120204.01","url":null,"abstract":"Some ion exchange resins like Cholestyramine (Duolite AP-143), provide extended gastric retention and have the ability to coat the gastric mucosa uniformly. The use of such mucoadhesive ion exchange resins is another attractive approach in the development of targeted formulations for the GIT. In pesent work, a mucoadhesive gastroretentive system for Repaglinide was developed and optimized using Duolite AP-143 resin by RSM. Studies were carried out to develop and optimize oral mucoadhesive beads for Repaglinide using ion exchange resin and chitosan. Resinates prepared were studied for the effect of pH and drug resin ratio on drug loading. Resin and resinates were evaluated for mucoadhesive property using falling liquid film method. Resin and resinates showed sufficient mucoadhesion strength when compared with other mucoadhesive polymers and other ion exchange resins. Dissolution study of Repaglinide resinate showed that Duolite AP-143 was able to sustain the release of drug. The study suggests that the mucoadhesive beads of Repaglinide provide sustained release over 8 h and also shows sufficient mucoadhesive strength with rabbit gastric mucosa.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116370186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Evaluation of Adenosine Deaminase (Ada) in Tuberculous Pleurisy 结核性胸膜炎中腺苷脱氨酶(Ada)的测定

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120201.01

S. Haque

引用次数: 9

Total Antioxidant Capacity in Serum of Plasmodium f alciparum Malarial Infected Patients Receiving Artemisinin-Based Combination Therapy 以青蒿素为基础联合治疗的恶性疟原虫疟疾患者血清总抗氧化能力

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120202.01

I. Onyesom, E. Osioma, O. Omoghene

{"title":"Total Antioxidant Capacity in Serum of Plasmodium f alciparum Malarial Infected Patients Receiving Artemisinin-Based Combination Therapy","authors":"I. Onyesom, E. Osioma, O. Omoghene","doi":"10.5923/J.AJMMS.20120202.01","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120202.01","url":null,"abstract":"This study was undertaken to assess the effect of artemisin-based combination therapy (ACT) on serum total antioxidant capacity (TAC). Eighty (80) consenting patients infected with P. falciparum malaria (40 receiving ACT and 40 yet to be treated) and 40 uninfected individuals in apparent good health were selected. Serum total antioxidant capacity was determined by the trolox equivalent method as earlier described. Results show that P. falciparum malarial infection signifi- cantly reduced (p < 0.05) serum TAC (1.25±0.11mM) when compared with values obtained from the uninfected, healthy subjects (1.76±0.09mM) and the infected patients receiving ACT (1.57±0.13Mm). ACT treatment enhanced serum TAC by 25.6% in comparison with the value obtained from malarial infected patients yet to receive treatment. Thus, treatment of P. falciparum malarial infection with ACT significantly (p<0.05) improved the capacity of antioxidants in serum of infected patients, and this represents an enhanced defense against oxidants including reactive oxygen species, ROS, generated by the malarial parasite's -induced stimulation of the immune response.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129034872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Rhinocerebral Mucormycosis: an Unusual Presentation 鼻-脑毛霉菌病:一种不寻常的表现

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120201.04

A. Rajeshwari, Gangadhara Somayaji

引用次数: 7

A Simple and Effective Methodology for the Sulfonylation of Alcohols and Aniline under Solvent Free Condition at Room Temperature 一种简单有效的室温无溶剂条件下醇类和苯胺磺化反应方法

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120201.08

R. Tayebee, F. Nehzat

引用次数: 6

Studies of Antioxidants and Xanthine Oxidase Inhibitory Potentials of Root and Aerial Parts of Medicinal Plant Capparis Spinosa L. 药用植物刺荆芥根和地上部位抗氧化剂及黄嘌呤氧化酶抑制电位的研究。

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120201.06

A. Baghiani, D. Ameni, S. Boumerfeg, Moufida Adjadj, Meriem Djarmouni, N. Charef, S. Khennouf, L. Arrar

{"title":"Studies of Antioxidants and Xanthine Oxidase Inhibitory Potentials of Root and Aerial Parts of Medicinal Plant Capparis Spinosa L.","authors":"A. Baghiani, D. Ameni, S. Boumerfeg, Moufida Adjadj, Meriem Djarmouni, N. Charef, S. Khennouf, L. Arrar","doi":"10.5923/J.AJMMS.20120201.06","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120201.06","url":null,"abstract":"Capparis spinosa aerial part and root extracts were prepared using solvents of varying polarity. Results showed that ethyl acetate extract (EAE) of the aerial part contains the highest concentration of phenolic compounds and flavonoids followed by the chloroform extract (CHE) of roots. The enzymatic methods were realised by the production of uric acid and reduction of cytochrome c. Result showed that all plant extracts were effective either in inhibiting the activity of XO or Cyt C. The IC50 ranges from 0.0226 ± 0.00019 to 4.32 ± 0.15g/l. The non enzymatic methods were conducted using in vitro techniques: In DPPH test, the radical scavenging activity for the root and aerial part extracts decreased in the following order CHE> EAE> CE and EAE> CE> CHE, respectively. In general the aerial part extracts had an antioxidant activity through s-carotene-linoleate model system and ferric reducing ability greater than that of root part. In conclusion, Capparis spinosa appears to be a valuable plant and could be used to treat conditions where inhibition of XOR and free-radicals scavenging action are warranted.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121929473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Antifertility Effects of Ethanolic Extract of Xylopia aethiopica on Male Reproductive Organ of Wistar Rats 埃塞俄比亚木醇提物对Wistar大鼠雄性生殖器官的抗生育作用

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120201.03

E. Nwangwa

引用次数: 30

Chronic Simvastatin Treatments Attenuate Ethanol Withdrawal Syndrome in Rats 慢性辛伐他汀治疗可减轻大鼠乙醇戒断综合征

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120202.06

M. M. S. Carrocini, A. L. R. L. Caxambú, N. Kelle, D. D. Lima, Júlia Niehues da Cruz, D. D. Magro, J. Cruz

{"title":"Chronic Simvastatin Treatments Attenuate Ethanol Withdrawal Syndrome in Rats","authors":"M. M. S. Carrocini, A. L. R. L. Caxambú, N. Kelle, D. D. Lima, Júlia Niehues da Cruz, D. D. Magro, J. Cruz","doi":"10.5923/J.AJMMS.20120202.06","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120202.06","url":null,"abstract":"Rodent models of ethanol withdrawal-induced anxiety have been used to explore the neurobiology underlying withdrawal and to evaluate the utility of therapeutic agents aimed at reducing withdrawal severity. Of the many tests of anxiety-like behavior, the elevated plus maze and open field are the most commonly used. In general, ethanol withdrawal decreases most or all of the individual behaviors recorded in these tasks, indicating the occurrence of an anxiogenic-like effect of withdrawal in rodents. Effects of sub-chronic simvastatin treatments on ethanol withdrawal syndrome were inves- tigated in rats. Ethanol (7.2% v/v) was given to adult male Wistar rats by a liquid diet for 30 days. Sub-chronic (once daily) simvastatin (1 or 10 mg/kg) or saline were administered to rats by oral gavage. After 24 hours of ethanol withdrawal on the simvastatin treatment rats were observed in behavior tests. The increases the time open arms entries in the elevated plus-maze and grooming in the open-field through the exposure to sub-chronic treatment with simvastatin in rats submitted to ethanol intake, indicating beneficial effects on ethanol withdrawal syndrome. Our results suggest that sub-chronic simvastatin treatment attenuates ethanol withdrawal syndrome in ethanol-dependent rats and this drug may be useful for treatment of ethanol-type dependence.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123215885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Multi-scale Bayesian Hypothesis Testing Approach for the Analysis of Prepulse Inhibition Test 脉冲前抑制试验的多尺度贝叶斯假设检验方法

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120204.04

Hongbo Zhou, Q. Cheng, Hong-Ju Yang, Haiyun Xu

引用次数: 0