American Journal of Medicine and Medical Sciences最新文献_第4页

Effects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and Glutamate Oxaloacetate Transaminase in Young and Old Rats 维生素B6对幼龄和老年大鼠脑谷氨酸焦盐转氨酶和谷氨酸草酰乙酸转氨酶的影响

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120201.07

M. Messripour, A. Mesripour

{"title":"Effects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and Glutamate Oxaloacetate Transaminase in Young and Old Rats","authors":"M. Messripour, A. Mesripour","doi":"10.5923/J.AJMMS.20120201.07","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120201.07","url":null,"abstract":"Excessive amounts of extracellular glutamate in brain are excitotoxic and lead to neuronal death. Glutamate pyrovate transamiase (GPT) and glutamate oxaloacetate transaminase (GOT) catalyze transamination of glutamate to alpha ketoglutarate. Because vitamin B6 is essential for the enzymes activities, this study was undertaken to examine the effect of vitamin B6 on age related changes of this enzyme in rat brain. Three and 30 months old male rats were injected with vitamin B6 and the animal's brains were homogenized in phosphate buffer and the enzymes activities were measured in the super- natant. The activities of the enzymes in aged rats were significantly lower as compared to that of young animals. Vitamin B6 induced activation of the brain enzymes in both ages, however, the activation was significantly pronounced in aged animals. Significant activation of GPT and GOT by vitamin B6 in aged rat brain may be resulted from either lower availability of vitamin B6 in aged animals, or lower affinity of the enzymes for pyridoxal 5-phosphate, which is likely to be related to conformational changes during aging. It is suggested that vitamin B6 may restore the activity of these enzymes during the brain aging.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115105443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Adolescent Cannabis Use - a Young Adult and Middle Age Urologic and Reproductive Dilemma: The Niger Delta Malady 青少年大麻使用-一个年轻的成年人和中年泌尿和生殖困境:尼日尔三角洲疾病

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120202.05

H. Ugboma, H. L. Aburoma, P. Ukaigwe

{"title":"Adolescent Cannabis Use - a Young Adult and Middle Age Urologic and Reproductive Dilemma: The Niger Delta Malady","authors":"H. Ugboma, H. L. Aburoma, P. Ukaigwe","doi":"10.5923/J.AJMMS.20120202.05","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120202.05","url":null,"abstract":"The sudden affluence in the Niger delta area of Nigeria due to the oil and gas industry, brought with it certain vices like the increasing use of Cannabis (Marijuana) by its younger population. This exposure to Cannabis has increased the incidence in urological and reproductive pathologies. Frequent marijuana use significantly increase testicular cancer risk and several urologic dysfunctions. This study clinically investigates the epidemiological evidence on the major adverse health effects of cannabis use and the link associated with urological dysfunctions and considers its implications for policy. A cross-sectional sample of 2290 males attending urology primary care clinics and inpatients in healthcare institutions in the Niger Delta Region was undertaken, 75 of the cases were included in the randomized follow-up study from March 2009 to March 2011. Those who use marijuana weekly or who have had exposure to marijuana since adolescents had twice the cancer risk, erectile and infertile anomalies, when compared to men who never smoked marijuana. Cannabis use was associated with urological dysfunctions like erectile dysfunctions, infertility and testicular cancer.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124098853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Study on Age at Menarche of School Going Girls in Bangladesh 孟加拉国学龄女童月经初潮年龄研究

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120202.02

Akifa Akther, R. Islam

{"title":"A Study on Age at Menarche of School Going Girls in Bangladesh","authors":"Akifa Akther, R. Islam","doi":"10.5923/J.AJMMS.20120202.02","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120202.02","url":null,"abstract":"The aim of this research is to study age at menarche of school going girls in Bangladesh. For this purpose, the data is acquired from Nilphamary Government Girls High School of the classes of five, six, seven and eight during1st June- 30 th June, 2008. In this study, it is to investigate the pattern of age at menarche of total respondents and the pattern of height, weight and body mass index by the age of the respondents in accordance with menarche and non-menarche. The age range of the respondents was between 10 to 14 years. Chi-square test and logistic regression analysis are employed in this paper. This study also displays the association of age at menarche with socio-demographic variables of respondents. It is realized from the association that early menarche for school going girl's height, weight, father income, body mass index, time spent by watching television and father educational qualification were highly significant but mother educational qualification, mother occupation, father occupation, number of siblings, order of birth, time spent by playing and mother time spent were insig- nificant. In logistic analysis, it was found that only height, weight and time spent by watching TV were significant which have positive effects on age at menarche.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"1103 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120870294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Evaluation of Hepatoprotective and Anticancer Properties of Aqueous Olive Leaf Extract in Chemically Induced Hepatocellular Carcinoma in Rats 橄榄叶水提物对化学诱导大鼠肝细胞癌的保肝抗癌作用评价

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20110101.03

N. Abdel-Hamid, M. A. Fawzy, M. El-Moselhy

{"title":"Evaluation of Hepatoprotective and Anticancer Properties of Aqueous Olive Leaf Extract in Chemically Induced Hepatocellular Carcinoma in Rats","authors":"N. Abdel-Hamid, M. A. Fawzy, M. El-Moselhy","doi":"10.5923/J.AJMMS.20110101.03","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20110101.03","url":null,"abstract":"Objectives: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. We aimed to test the role of aqueous olive leaf extract (AOLE) in modulating metabolic disorders occurring in hepatic malignancy induced by trichloroacetic acid (TCA). Design: Eight groups of rats were assigned as follows: First, untreated normal control. Second, treated with 5-fluorouracil (5-FU), (75mg/kg), intraperitoneally (IP) once weekly for 3 weeks. Third, treated with oral AOLE (500mg/kg) once daily for 28 days. The 4 th group co-treated with AOLE and 5-FU as mentioned above. The 5 th group treated with oral daily doses of TCA (500mg/kg) for five days. The 6 th group treated with TCA for 5 days, from the sixth day with 5-FU for 3 weeks. Group 7 given TCA then, with AOLE. Group 8 received TCA, 5-FU and AOLE. Blood samples were withdrawn after 28 days from carotid vein. Liver tissues were histologically studied. Results: TCA showed neoplastic tissue features, greatly improved by treatment with AOLE and 5-FU combination. TCA significantly increased blood ALT, AST, alkaline phosphatase (ALP) and acetyl CoA synthase (fatty acid synthase , FAS) activities, total bilirubin (T Bil) , triglycerides (TG), total glycosaminoglycans (TGAGs), alpha-fetoprotein (AFP), reduced serum total lipoprotein lipase (TLPL) activity. AOLE, combined with 5-FU produced a pronounced improvement in most of studied parameters. Conclusion: AOLE showed promising hepatoprotective and adjuvant anticancer properties if combined with 5-FU.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125601868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The Impact of Incubators on Noise Transmission Produced by High-Frequency Oscillatory Ventilator Inside the Neonatal Intensive Care Unit 新生儿重症监护病房内保温箱对高频振荡呼吸机噪声传播的影响

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20110101.04

H. Salama, A. Azzam, S. A. Omar, K. Abdulhadi

{"title":"The Impact of Incubators on Noise Transmission Produced by High-Frequency Oscillatory Ventilator Inside the Neonatal Intensive Care Unit","authors":"H. Salama, A. Azzam, S. A. Omar, K. Abdulhadi","doi":"10.5923/J.AJMMS.20110101.04","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20110101.04","url":null,"abstract":"Background: Use of the high-frequency oscillatory ventilator (HFOV) is a common practice inside the neonatal intensive care unit (NICU). There is a concern regarding the level of noise produced by HFOV inside the NICU. Objective: To evaluate and define the noise intensity produced by the HFOV and the impact of the incubator on the transmission of noise in different places inside the NICU. Methods: Using a noise analyzer, the noise produced by the HFOV was measured in two setups: inside a quiet room, and inside the NICU during working hours. Measurements were repeated three times: first, inside and outside the tested incubator, and secondly, inside and outside the neighboring incubator. Each measurement was recorded against different HFOV amplitude and frequency settings. Each measurement lasted five minutes, where the highest and lowest readings were recorded every minute, and the mean values of noise intensity were calculated. Results: Noise level was increased by more than 40% after using HFOV (50 dB vs. 84 dB and 45 vs. 78) both inside and outside the incubator during the test. The mean noise levels recorded inside the NICU and the quiet room were 86(±5) dB and 78 (±2) dB respectively. The noise records progressively reduced as HFOV ▲P decreased to 20 cmH2O no matter the frequency used. Conclusions: The HFOV produces significant noise which is of concern. The noise was augmented within the tested incubator while reduced inside the neighboring incubator. Given the data presented, it is recommended that noise protective tools should be used for infants receiving respiratory support using this machine as well as neighboring infants who are near a HFOV.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130309826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Surgical Decompression of Pudendal Nerve by Transperineal Approach Using a Balloon Probe 球囊探头经会阴入路阴部神经减压术

American Journal of Medicine and Medical Sciences Pub Date : 2012-08-31 DOI: 10.5923/J.AJMMS.20120204.05

E. Bisschop, R. Nundlall

{"title":"Surgical Decompression of Pudendal Nerve by Transperineal Approach Using a Balloon Probe","authors":"E. Bisschop, R. Nundlall","doi":"10.5923/J.AJMMS.20120204.05","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120204.05","url":null,"abstract":"Since 2009 may to 31 january 2012, 512 patients (371 females, 141 males) have benefited fro m a pudendal nerve (PN) deco mpression by transperineal approach using a ballon probe. These patients had clinical sympto ms of pudendal neuralgia. Neurophysiological tests based on the staged sacral reflexes, on ultrasound investigations of pudendal vessels and on a pelvic floor u ltrasounds evoked a zone of compressive hyperpressure at the level of the axis infrapirifo rmis area-ischiorectal fossa. All of these 512 patients, in jection block at the level of the infrapirifo rmis area appeared positive between 1 to 9 months. Patients were known for this pathology since many years. Among these 512 patients, 66 had already PN decomp ression, 27 by t ransgluteal approach, 36 by transvaginal (♀)/transischiorectal (♂) approach and 3 by transperineal approach (Shakik extended) but without clinical efficiency. All of these 512 patients, surgical decompression was done by transperineal approach using a balloon probe. Surgical methodology, post-op follow up and results are reported hereby, which appear quite successful with few risks to make worse the pathology and no risk on pelvic static.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114928847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Alleviating Effect of Phyllanthus niruri on Sensorimotor and Cognitive Changes Induced by Subacute Chlorpyrifos Exposure in Wistar Rats 甘油三酯对亚急性毒死蜱致Wistar大鼠感觉运动和认知变化的缓解作用

American Journal of Medicine and Medical Sciences Pub Date : 2012-05-09 DOI: 10.5923/J.AJMMS.20120203.05

S. Ambali, A. Makinde, M. Shittu, S. A. Adeniyi, Favour O. Mowuogwu

{"title":"Alleviating Effect of Phyllanthus niruri on Sensorimotor and Cognitive Changes Induced by Subacute Chlorpyrifos Exposure in Wistar Rats","authors":"S. Ambali, A. Makinde, M. Shittu, S. A. Adeniyi, Favour O. Mowuogwu","doi":"10.5923/J.AJMMS.20120203.05","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120203.05","url":null,"abstract":"Objective: Studies in animal models and humans have shown that chlorpyrifos (CPF) causes sensorimotor and cognitive changes. Apart from inhibiting acetylcholinesterase (AChE), the induction of oxidative stress is one of the other molecular mechanisms implicated in OP-evoked toxicity. The present study evaluated the alleviating effect of Phyllanthus niruri, a flavonoid rich plant, on subacute CPF-evoked sensorimotor and cognitive changes in Wistar rats. Design: Thirty five adult male Wistar rats divided into five groups of seven rats were used for the study. Groups 1 and II were given soya oil (2 ml/kg) and CPF (10.6 mg/kg~1/8 th of LD50), respectively. Group III was administered methanol extract of Phyllanthus niruri (MEP) at 500 mg/kg only. Group IV was administered MEP (250 mg/kg) and CPF (10.6 mg/kg), 30 min later while group V was administered with MEP (500 mg/kg) and CPF (10.6 mg/kg), 30 min later. The regimens were administered by gavage once daily for 28 days during which periodic evaluation of sensorimotor and cognitive performances were carried out. Thereafter, the brain was evaluated for AChE activity and malonaldehyde (MDA) concentration. Results: CPF caused defi- cits in sensorimotor reflexes and cognition, increased brain MDA concentration and decreased AChE activity, which were all mitigated by MEPN. Conclusion: The study concludes that mitigation of sensorimotor and cognitive deficits elicited by CPF was mitigated by MEP partly due to the antilipoperoxidative and acetylcholinesterase restoration properties of its flavonoid constituent.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124989520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Co-Morbid Factors Related to Surgical Complications in Kidney Transplant Patients 肾移植患者手术并发症相关的共病因素

American Journal of Medicine and Medical Sciences Pub Date : 2012-05-09 DOI: 10.5923/J.AJMMS.20120203.01

M. Abou-Jaoude, H. Nasser, A. Khalaf, W. Abou-Jaoude, Z. Daoud

{"title":"Co-Morbid Factors Related to Surgical Complications in Kidney Transplant Patients","authors":"M. Abou-Jaoude, H. Nasser, A. Khalaf, W. Abou-Jaoude, Z. Daoud","doi":"10.5923/J.AJMMS.20120203.01","DOIUrl":"https://doi.org/10.5923/J.AJMMS.20120203.01","url":null,"abstract":"We have studied retrospectively the demographics and different post transplantation morbidities associated with surgical complications in 200 kidney transplant recipients between May 1997 and January 2008. Patients were divided into 2 groups: Group I including 177 patients without surgical complications and Group II including 23 patients who had surgical complications. Baseline demographics and later co-morbidities were analyzed. The baseline characteristics be- tween the 2 groups did not differ significantly, including donor and recipient age and sex, recipient's body mass index, cause of original renal disease, transplantation date, dialysis duration, recipient's degree of sensitization and pre-transplantation diabetes. However significant difference between the 2 groups included: pre and post-transplant hemo- globin blood level differences (2.6 ± 1.8 mg/dl in Group I versus 4.1 ± 2.0 mg/dl in Group II), number of post-transplant transfusions (0.4 ± 0.8 in Group I versus 2.2 ± 3.7 in Group II), duration of hospital stay (10.9 ± 4.3 days in Group I, versus 17.5 ± 9.2 days in Group II), mean serum creatinine upon discharge (1.47 ± 0.84 mg/dl in Group I versus 2.7 ± 2.87 mg/dl in Group II), death and graft failure at 6 months post-transplant (2 in Group I versus 2 in Group II and 3 in Group I versus 5 in Group II respectively). We conclude that surgical complications were associated with significant short and long term co-morbidities, including duration of hospital stay, serum creatinine upon discharge, and death and graft failures at 6 months post-transplantation.","PeriodicalId":124628,"journal":{"name":"American Journal of Medicine and Medical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117076986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Toxicity Effects of Amlodipine on the Testis Histology in Adult Wistar Rats 氨氯地平对成年Wistar大鼠睾丸组织的毒性作用

American Journal of Medicine and Medical Sciences Pub Date : 2012-05-09 DOI: 10.5923/J.AJMMS.20120203.02

A. Adebayo, A. Olamide, A. Helen, H. Oluwaseun, Soyebo Olusegun, Huthman Adebukola Selimot

引用次数: 6

Dextrocardia With Situs Inversus Totalis in an Adult Nigerian: a Case Report 尼日利亚1例成人右心逆位1例

American Journal of Medicine and Medical Sciences Pub Date : 2012-05-09 DOI: 10.5923/J.AJMMS.20120203.06

D. Uchenna, J. De, Anyalechi Ji

引用次数: 12