Toxicity Effects of Amlodipine on the Testis Histology in Adult Wistar Rats

Abstract

Amlodipine is one of the calcium channel blocker class of antihypertensives used in the treatment of hypertension. This study was carried out to appraise the toxicity effects of Amlodipine on the testis histology in Adult Wistar rats based on the fact that amilodipine is usually consumed by the elderly who have a slow metabolic rate hence leading to accumulation of the drug in their system causing toxicity. The rats were divided into 3 groups: one group one was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively for 5 weeks. Our preliminary observations showed that administration of Amlodipine lead to an abnormal morphology of the testis in that, it had a deleterious effect on the seminiferous tubules in a dose related fashion.By these preliminary observations, alteration in the testis histology may have implication for infertility in man.