Frontiers in Endocrinology最新文献

{"title":"Triglyceride glucose index - body mass index predicts insulin resistance, metabolic syndrome and associates with impaired ovulation in Chinese women with polycystic ovary syndrome.","authors":"Muxin Guan, Jiaxing Feng, Mengyi Zhu, Yu Wang, Baichao Shi, Fengjuan Lu, Jiannan Yu, Zhuwei Gao, Hong Yu, Xiaoke Wu","doi":"10.3389/fendo.2025.1653636","DOIUrl":"https://doi.org/10.3389/fendo.2025.1653636","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) and metabolic syndrome (MetS) are highly prevalent and pathophysiologically central features of polycystic ovary syndrome (PCOS). However, their assessment is challenged by the limitations of gold-standard diagnostic methods. The clinical utility of the novel triglyceride glucose index - body mass index (TyG-BMI) for predicting IR, MetS, and its association with fertility outcomes in Chinese women with PCOS remains unexplored and warrants investigation.</p><p><strong>Objective: </strong>To evaluate the association between TyG-BMI and IR and MetS, and fertility outcomes in women with PCOS.</p><p><strong>Methods: </strong>We used data of 855 participants of the Acupuncture and Clomiphene for Chinese Women with Polycystic Ovary Syndrome (PCOSAct) trial. Linear trend tests and logistic regression evaluated relationships between TyG-BMI and anthropometric, hormonal, metabolic, and fertility outcomes. Receiver operating characteristic (ROC) curves assessed TyG-BMI's predictive value for IR and MetS. RCS analysis was used to examine threshold effects between TyG-BMI and IR, MetS, and ovulation. A likelihood ratio test was further incorporated to validate the model fit.</p><p><strong>Results: </strong>TyG-BMI was positively association with IR (OR: 2.747, 95% CI: 1.942-3.887) and MetS (OR: 4.176, 95% CI: 2.278-7.653). TyG-BMI had a strong predictive performance, with AUC_IR of 0.841 and AUC_MetS of 0.899. For fertility outcomes, after adjusting for confounders, only ovulation showed a significant negative association (OR: 0.984, 95% CI: 0.973-0.994). The study revealed significant nonlinear associations between TyG-BMI and both IR and MetS, but a linear link with ovulation status. The inflection point occurred at a TyG-BMI of 203. Below this, IR risk increased progressively with TyG-BMI, plateauing above it. Above 203, MetS prevalence continued to increase, while ovulation rates declined inversely.</p><p><strong>Conclusion: </strong>Elevated TyG-BMI is strongly associated with worsened IR and MetS in PCOS women, serving as a practical screening tool for these conditions, while also demonstrating a potential negative impact on ovulation.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1653636"},"PeriodicalIF":4.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chapter 3. Impact of estrogens on hemostasis.","authors":"Frank Z Stanczyk, Intira Sriprasert, Shinnisha Chulapongwanich, Jane L Yang, Franca Fruzzetti","doi":"10.3389/fendo.2025.1617731","DOIUrl":"https://doi.org/10.3389/fendo.2025.1617731","url":null,"abstract":"<p><p>It is well established that estrogens increase the risk of both arterial and venous thrombosis. Abnormally high levels of some coagulation factors combined with a decrease in anticoagulation factors contribute to thrombotic risk. Although estrogens are known to affect multiple hemostatic markers, the exact molecular mechanism of estrogen-induced thrombosis is unclear. However, small changes in these markers with different types, doses, and/or routes of estrogens may increase thrombotic risk. Most studies on the effect of estrogens have been carried out in premenopausal women using combined oral contraceptives (COCs); studies in postmenopausal women using hormone therapy (HT) are scarce. Short-term studies comparing hemostatic parameters in women receiving either ethinyl estradiol (EE) or estradiol (E₂), each combined with a different progestin, generally show that EE- and E₂-based COCs have minimal hemostatic effects on most markers and weaker effects on some markers with E2. The novel estrogen estetrol (E₄), emerging as a promising option for both hormonal contraception and postmenopausal HT, appears to have a neutral hemostatic effect. The increased procoagulant factors and decreased anticoagulatory mechanisms observed with estrogen use have been linked to an increased venous thromboembolism (VTE) risk and have been studied in women using hormonal contraception or HT. In contraceptive studies, it has been shown that estrogen dosage plays a role in VTE risk, as EE increases this risk in a dose-dependent manner. Although some studies suggest that the progestin type in COCs may affect VTE risk, other studies have found no difference in risk between androgenic and non-androgenic progestins. As for the E₄-based COC, it is currently being evaluated for VTE risk in post-marketing studies. Regarding postmenopausal HT, both the CEE-alone and CEE/MPA arms of the Women's Health Initiative trial showed an increased risk of VTE. However, the results are mixed regarding the impact of oral E₂ on VTE risk. Although some data suggest a lesser impact of transdermal HT on this risk, further studies are needed to confirm this finding.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1617731"},"PeriodicalIF":4.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The deletion of the arginine vasopressin 1a receptor impairs sexual and maternal behavior.","authors":"D Aspesi, E Sambor, M C Stoehr, J Taylor, Z A Grieb, K L Huhman, H E Albers","doi":"10.3389/fendo.2025.1649706","DOIUrl":"10.3389/fendo.2025.1649706","url":null,"abstract":"<p><strong>Introduction: </strong>Arginine-vasopressin (AVP) and its V1a receptor (V1aR) within the social behavior neural network are critical modulators of social behavior across species. Using CRISPR-Cas9-mediated gene editing, we previously demonstrated that Syrian hamsters of both sexes with V1aR knockout (V1aRKO) exhibit elevated social communication (i.e., odor-induced flank marking) and aggression compared to wild-type (WT) littermates. While most AVP research has focused on males, V1aRs have also been implicated in female sexual and maternal behaviors. Here, we investigated the effects of V1aRKO on reproductive and maternal behavior in adult female hamsters.</p><p><strong>Methods: </strong>To assess mating behavior, a sexually experienced male hamster was introduced into the home cage of a virgin, estrus female, and their interactions were video-recorded for 30 minutes following the male's first ejaculation or until the female displayed aggression. To evaluate maternal care, home-cage behavior was video-recorded for 5 minutes on postpartum days (PPD) 0 to 3, across four timepoints per day (two times in the dark and two in the light phase), and pup-directed and non-directed behaviors were quantified.</p><p><strong>Results: </strong>V1aRKO and heterozygous (Het) females received significantly fewer and shorter-duration mounts from males than did WT females, suggesting reduced sexual receptivity or attractiveness. Other copulatory and social behaviors, including aggression, during the observation period were unaffected. In regard to maternal behavior, V1aRKO females exhibited reduced pup-directed behaviors relative to Het and WT dams, although time spent in the nest was comparable across groups. V1aRKO females also engaged in more non-maternal behaviors (e.g., self-grooming, digging, and burying) than did Het or WT dams.</p><p><strong>Conclusions: </strong>These findings support the hypothesis that V1aRs are essential for the robust expression of female sexual receptivity and maternal caregiving in Syrian hamsters. This work underscores the importance of studying the AVP system across sexes and species to fully understand its role in regulating complex social behaviors.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1649706"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hashimoto's thyroiditis and thyroid hormone sensitivity in euthyroid individuals: their association with carotid plaque in northeast China.","authors":"Yanmeizhi Wu, Jingxue Sun, Yanan Ni, Minnan Wang, Hong Qiao","doi":"10.3389/fendo.2025.1605875","DOIUrl":"10.3389/fendo.2025.1605875","url":null,"abstract":"<p><strong>Background: </strong>Carotid plaque is a hallmark of systemic atherosclerosis, which underlies the pathology of cardiovascular and cerebrovascular events. Both thyroid hormones and Hashimoto's thyroiditis (HT) affect carotid plaque formation, but their impact on individuals with normal thyroid function remains unclear.</p><p><strong>Methods: </strong>Clinical data, including demographics and medical history, were collected. Carotid and thyroid ultrasound, thyroid function tests, thyroid autoantibody measurements, and lipid profiles were performed. A retrospective analysis was conducted to explore the correlation of Hashimoto's thyroiditis (HT) and thyroid hormone sensitivity with carotid plaque risk in euthyroid individuals, with additional subgroup analyses.</p><p><strong>Results: </strong>A total of 459 euthyroid patients were included. Thyroid hormone sensitivity indices were higher in the HT group than in the non-HT group. Significant differences in gender, age, smoking duration, diabetes mellitus (DM), coronary artery disease, ischemic stroke, and thyroid hormone sensitivity were observed between patients with and without carotid plaque. Among these factors, sex, age, coronary heart disease, and thyroid hormone sensitivity were identified as independent risk factors for carotid plaque. Differences in plaque size and thickness were noted between the HT and non-HT groups. Notably, in patients with DM, findings regarding plaque risk and characteristics diverged from those in other subgroups.</p><p><strong>Conclusion: </strong>In euthyroid individuals, HT impairs thyroid hormone sensitivity. Increased thyroid hormone sensitivity (as reflected by higher sensitivity indices) elevates carotid plaque risk. While HT may exert a modest protective effect against plaque formation, it contributes to the deterioration of plaque quality in patients with diabetes mellitus and dyslipidemia and elderly individuals with increased thyroid hormone sensitivity.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1605875"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of mean arterial pressure on reproductive endocrine characteristics in infertile patients with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial.","authors":"Baichao Shi, Yu Wang, Rong Luo, Yang Liu, Fengjuan Lu, Muxin Guan, Jiannan Yu, Zhuwei Gao, Xiaoke Wu","doi":"10.3389/fendo.2025.1594813","DOIUrl":"10.3389/fendo.2025.1594813","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to evaluate the association between mean arterial pressure (MAP) and anthropometric, metabolic, and endocrine parameters in Chinese infertile women with polycystic ovary syndrome (PCOS).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 1,000 PCOS subjects were enrolled in the clinical trial project of Acupuncture and Clomiphene in the treatment of PCOS infertility patients (PCOSAct). Of these, 998 patients were selected for this study. Linear trends and regression analyses were conducted to evaluate the association between MAP and anthropometric, metabolic, and endocrine parameters. Logistic regression was employed to estimate the association between MAP and risk of insulin resistance (IR), nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia. The receiver operating characteristics (ROC) curve was used to determine the predictive value of the MAP for IR, NAFLD and hyperlipidemia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Linear trends revealed that the MAP was positively associated with age, height, body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), systolic blood pressure (SBP) and diastolic blood pressure (DBP), hirsutism score, and acanthosis nigricans score, fasting blood glucose (FBG), fasting insulin (FINS), the homeostatic model assessment for insulin resistance (HOMA-IR), low-density lipoprotein (LDL), triglycerides (TG), total cholesterol (TC), apolipoprotein B (ApoB), ApoB/apolipoprotein A1 (ApoA1) ratio, total testosterone (TT), and free androgen index (FAI), as well as the prevalence of IR, metabolic syndrome (MetS), NAFLD, and hyperlipidemia. Conversely, MAP was negatively correlated with the quantitative insulin sensitivity check index (QUICKI), high-density lipoprotein (HDL), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), the LH/follicle stimulating hormone (FSH) ratio, and anti-Müllerian hormone (AMH). After adjusting for age and BMI, a significant linear relationship was observed between MAP and WC, WHR, hirsutism score, FBG, LDL, TG, TC, ApoB, and ApoB/ApoA1 ratio. Logistic regression analysis demonstrated that participants in the highest quartile (Q4) of MAP had no significantly higher odds ratios (OR) for IR, NAFLD and hyperlipidemia after adjusting for confounding factors. The ROC curve analysis indicated that the AUC&lt;sub&gt;IR&lt;/sub&gt; was 0.593 (95%CI: 0.557 ~ 0.629), with 85.9% sensitivity and 28.8% specificity at a cut-off value of 82.83, and the AUC&lt;sub&gt;NAFLD&lt;/sub&gt; was 0.621 (95%CI: 0.554 ~ 0.687), with 69.4% sensitivity and 53.5% specificity at a cut-off value of 87.17, and the AUC&lt;sub&gt;hyperlipidemia&lt;/sub&gt; was 0.555 (95% CI: 0.518 ~ 0.592), with 39.5% sensitivity and 70.00% specificity at a cut-off value of 90.83.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Elevated MAP is associated with dysregulation of glucose and lipid metabolism and alterations in endocrine hormone levels. It may thus serve as a promising screening a","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1594813"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between obstructive sleep apnea and male reproductive function: a cross-sectional study with stratified analysis.","authors":"Wei Zhang, Xu Wu, Yuyang Zhang, Hui Gao, Guodong Liu, Hao Geng, Ci Zou, Xiansheng Zhang","doi":"10.3389/fendo.2025.1636484","DOIUrl":"10.3389/fendo.2025.1636484","url":null,"abstract":"<p><strong>Objective: </strong>Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder known to affect systemic physiology. Emerging evidence suggests a potential relationship between OSA and male reproductive health, but this association remains insufficiently characterized. This study aims to explore the link between OSA, semen quality, and sex hormone profiles in reproductive-aged men.</p><p><strong>Method: </strong>A total of 108 newly diagnosed OSA patients aged 20-40 years, who underwent full-night polysomnography (PSG) at the Respiratory Sleep Center of the Second Affiliated Hospital of Anhui Medical University between 2022 and 2024, were included. The control group consisted of 84 healthy adult males undergoing fertility evaluations during the same period at the same hospital. All participants completed physical examinations, semen analysis, and sex hormone testing. OSA severity was classified based on the apnea-hypopnea index (AHI) obtained from PSG in the patient group.</p><p><strong>Results: </strong>Compared with controls, men with OSA had significantly higher body weight and BMI, as well as lower sperm concentration (90.0 vs. 129.3 ×10⁶ml), total motility (68.6% vs. 71.0%), progressive motility (63.8% vs. 66.6%), and testosterone levels (13.1 vs. 21.8 nmol/L) (all p < 0.01). Stratified analyses showed a stepwise decline in semen parameters and oxygen saturation with increasing OSA severity. In multivariable analysis, AHI was independently associated with reduced sperm concentration (β = -0.393), total motility (β = -0.640), and progressive motility (β = -0.623) (all p < 0.001).</p><p><strong>Conclusion: </strong>OSA is independently associated with impaired semen quality and lower testosterone levels in reproductive-aged men. These findings highlight the potential reproductive consequences of untreated OSA and underscore the importance of early screening and intervention.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1636484"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of type 2 diabetes-related diabetic kidney disease attributable to low physical activity from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021 with predictions to 2050.","authors":"Mei Wang, Ruihua Yan, Wenbo Xia, Yongcai Gao, Yonghua Liu, Li Bao, Hongyan Luo, Jing E, Hui Wang, Bo Li, Yali Zheng","doi":"10.3389/fendo.2025.1625973","DOIUrl":"10.3389/fendo.2025.1625973","url":null,"abstract":"<p><strong>Background: </strong>Low physical activity (LPA) significantly heightens the susceptibility of both type 2 diabetes mellitus (T2DM) and chronic renal disease. Nearly half of population diagnosed with T2DM globally worsen into diabetic kidney disease (DKD). Focusing on physically inactive populations, we aimed to comprehensively evaluate the trends over time and regional changes in T2DM-associated DKD attributable to LPA burden.</p><p><strong>Methods: </strong>We utilized data of the 2021 Global Burden of Disease (GBD) Study to initially assess the worldwide effects of T2DM-associated DKD attributable to LPA by computing the numbers and age-standardized rates (ASRs) of death, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs), categorized by subtypes in 2021. Linear regression model was applied to analyze the illness burden from 1990 to 2021. Furthermore, cluster analysis was performed to assess the regional differences in disease burden across GBD regions. Lastly, to forecast the illness burden for the next 25 years, we utilized the autoregressive Integrated Moving Average (ARIMA) and Excess Risk (ER) models.</p><p><strong>Results: </strong>In 2021, the fatalities attributed to T2DM-related DKD attributable to LPA amounted to 30835 (95%UI: 12346-51646) cases, with 698484 (95%UI: 275039-1158032) DALYs. The ASRs of death and DALYs were 0.38 (95%UI: 0.15-0.63) and 8.19 (95%UI: 3.21-13.6) per 100000 individuals, respectively. Between 1990 and 2021, there was a notable escalation in deaths, DALYs, YLDs, and YLLs, as well as their ASRs. The highest burden was observed among males, older adults (aged 70 years and above), and middle Socio-demographic Index (SDI). Significant differences were noted in the disease burden among various regions and countries as defined by the GBD study. Predictive analyses indicate a continued escalation of this burden by the year 2050.</p><p><strong>Conclusions: </strong>The global impact of DKD attributable to LPA remains considerable, with significant disparities noted across different genders, ages, and regions. To mitigate this burden, it is crucial to implement effective interventions aimed at addressing physical inactivity, specifically designed for targeted demographic groups.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1625973"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The strategic role of lipidomics in biomarker identification and diagnosis of gynecological diseases.","authors":"Menghui Hou, Xinying Chu, Shuxin Wang, Qingyue Zhang, Mingjie Ma, Jing Ma","doi":"10.3389/fendo.2025.1546512","DOIUrl":"10.3389/fendo.2025.1546512","url":null,"abstract":"<p><p>Lipidomics, an emerging field in medical research, has deepened our understanding of lipid metabolism, signal transduction pathways, and intercellular communication through qualitative and quantitative analyses of patient lipid profiles. It has closely linked these biological processes to the occurrence and progression of diseases, opening new avenues of research and providing new perspectives on the diagnosis, treatment, and personalized medicine of clinical diseases. Gynecological diseases have a profound impact on women's health but often face challenges due to delayed diagnosis and inadequate treatment options. Lipids play a crucial role in regulating cell proliferation, differentiation, and signal transduction, making them significant in the occurrence and development of gynecological diseases. The technological progress in lipidomics has greatly advanced our comprehension of lipid metabolism and biochemical mechanisms in these diseases, while also offering new technical pathways for identifying potential biomarkers. Thus, this review summarized the application of lipidomics in gynecological diseases, especially those with high incidence rates such as ovarian cancer, cervical cancer, and endometriosis, to assesses its application potential in the diagnosis, prognosis monitoring, and development of new treatment strategies for gynecological diseases, and discusses its future development trends.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1546512"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing post-operative hypothyroidism treatment: rat thyroid autotransplantation into a pre-vascularized, retrievable cell pouch™ device.","authors":"Arash Memarnejadian, Pardis Pakshir, Madison Tomlinson, Farideh Berjisian, Ligia Dortas Maffei, Ben Muirhead, Jonathan Mofford, Babak Ataei Mehr, Vijay Parikh, Frank R Shannon, Pericles Calias, Philip M Toleikis","doi":"10.3389/fendo.2025.1642916","DOIUrl":"10.3389/fendo.2025.1642916","url":null,"abstract":"<p><strong>Introduction: </strong>To overcome the limitations of lifelong hormone replacement therapy for post-operative hypothyroidism, we propose autologous thyroid transplantation into the Cell Pouch™ (CP), an implantable and retrievable medical device that supports vascularization and a homeostatic environment for cell grafting. The CP is currently in clinical trials for islet transplantation in type-1 diabetes, demonstrating its capacity to support long-term graft viability. Here, we apply the CP for thyroid tissue transplantation, leveraging the natural gland's regulatory capabilities to benefit patients unresponsive to hormone therapy. Building on previous research validating CP's support for human thyroid grafts in a mouse model, this study evaluates its therapeutic potential in a rat model mimicking clinical thyroidectomy and autologous transplantation.</p><p><strong>Methods: </strong>We used 24 Lewis rats to assess the CP's safety and efficacy. After a five-week post-implantation vascularization period, thyroidectomy was performed in 15 rats, and their glands were transplanted into the CP. A non-transplant group (n=4) underwent thyroidectomy only, and a control group (n=5) received no interventions. Hormone levels (total T3, free T4, TSH) were monitored weekly for 22 weeks. Histology and scintigraphy at endpoint evaluated graft function.</p><p><strong>Results and conclusion: </strong>Rats with thyroid grafts in the CP restored fT4 and T3 to baseline by weeks 4 and 7, respectively. Explantation reversed this effect. Histological analysis showed well-differentiated follicles with minimal inflammation. Scintigraphy confirmed graft viability. No adverse effects were observed in hematological, liver, or kidney parameters. These findings demonstrate that CP-enabled thyroid transplantation restores function post-thyroidectomy and is safely retrievable, with no residual thyroid tissue, marking a significant safety advancement.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1642916"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-body vibration administered during a 3-week in-hospital multidisciplinary body weight reduction program increases resting energy expenditure in obese adolescents, a randomized clinical trial.","authors":"Sofia Tamini, Gabriella Tringali, Roberta De Micheli, Mario Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Alessandro Sartorio","doi":"10.3389/fendo.2025.1642437","DOIUrl":"10.3389/fendo.2025.1642437","url":null,"abstract":"<p><strong>Background: </strong>Pediatric obesity is a growing global health concern, and interventions aimed at increasing resting energy expenditure (REE) have gained attention as complementary strategies to dietary restriction. Whole-body vibration (WBV), an innovative exercise mimetic, may offer metabolic and functional benefits, particularly in populations with limited exercise tolerance. This study was a randomized clinical trial aimed to evaluate the effects of incorporating WBV into a 3-week in-hospital multidisciplinary body weight reduction program (BWRP) in male adolescents with obesity.</p><p><strong>Methods: </strong>Twenty-three male adolescents with obesity (mean age: 15.7 ± 1.3 years; mean body mass index (BMI): 38.5 ± 5.6 kg/m²) hospitalized for a 3-week BWRP were randomly assigned to a control group receiving the standard BWRP (subgroup A, n = 12) or an experimental group receiving BWRP plus WBV sessions (subgroup B, n = 11). Anthropometric and clinical parameters, REE, and lower limb muscle power, evaluated using the stair-climbing test, were assessed before and after the intervention.</p><p><strong>Results: </strong>Both subgroups demonstrated significant reductions in body weight and BMI. REE showed a significant Time × Group interaction (p < 0.01), indicating differential responses between the two intervention groups. WBV training significantly increased REE in subgroup B, from 2470.1 ± 249.6 kcal/day at baseline to 2733.0 ± 310.8 kcal/day post-intervention (Δ = +262.9 kcal, p < 0.001). In contrast, subgroup A showed no significant change in REE, with values decreasing from 2204.0 ± 307.4 kcal/day to 2020.8 ± 442.5 kcal/day (Δ = -183.2 kcal, p = ns). REE change was supported by significant Time × Group interaction in a two-way repeated measures ANOVA (p = 0.002). Furthermore, a significant post-intervention correlation emerged between REE and anaerobic power only in subgroup B.</p><p><strong>Conclusion: </strong>The addition of WBV to a structured BWRP significantly increased REE in obese adolescents, beyond the effects of the BWRP alone. This finding supports the use of WBV as a promising adjunct strategy to conventional interventions in pediatric obesity.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1642437"},"PeriodicalIF":4.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}