Frontiers in Endocrinology最新文献

{"title":"Associations between cardiometabolic index with kidney stones: evidence from NHANES 2007-2018.","authors":"Suquan Zhong, Guoliang Li, Chao Tian, Maolin Jiang, Dong Chen, Hangtao Wang, Pengfei Diao","doi":"10.3389/fendo.2025.1485477","DOIUrl":"10.3389/fendo.2025.1485477","url":null,"abstract":"<p><strong>Background: </strong>Kidney stones are a prevalent disorder that is linked to a range of metabolic variables. The cardiometabolic index (CMI) is a newly developed combined measure used to evaluate the state of cardiometabolic health. Nevertheless, the association between CMI and kidney stone remains little investigated.</p><p><strong>Methods: </strong>In this study, cross-sectional analysis was done on NHANES data from 2007 to 2018. The association between the prevalence of kidney stones and the CMI was investigated using a logistic regression analysis. To look into the nonlinear link between them, we used restricted cubic spline (RCS) analysis. The study was made more reliable and accurate by using sensitivity analysis and subgroup analysis to look for factors that may have contributed to the different results.</p><p><strong>Results: </strong>A significant association was seen between increased CMI and the prevalence of kidney stones (OR = 1.19, 95% CI: 1.06-1.32). The RCS analysis revealed crucial CMI values that exhibited a robust association within a certain range. Subgroup studies revealed that this link was particularly prominent among those below the age of 50, females, obese, CKD and diabetes patients. The dependability of the study's conclusions was further established using sensitivity analysis.</p><p><strong>Conclusion: </strong>This study established a notable association between CMI and a higher prevalence of kidney stones, emphasizing the significance of CMI as a comprehensive measure for evaluating metabolic risk. Furthermore, it suggests that monitoring CMI levels could be beneficial in identifying populations with a high prevalence of kidney stones.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1485477"},"PeriodicalIF":3.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothalamic GABAergic neurons: their roles in health and metabolic diseases.","authors":"Bingwei Wang, Yang Yu, Juan Li, Yu Xiong, Xin Zhang, Ying Wan, Ruimao Zheng, Chunxiang Zhang","doi":"10.3389/fendo.2025.1551741","DOIUrl":"10.3389/fendo.2025.1551741","url":null,"abstract":"<p><p>Hypothalamic GABAergic neurons are important in regulating metabolic homeostasis and energy balance. Serving as critical integrators of catabolic and anabolic processes, these neurons orchestrate a broad spectrum of metabolic functions, including feeding, nutrient metabolism, fluid homeostasis, basal metabolism, thermoregulation, and circadian rhythms. Recent advances in neuroscience have facilitated a deeper exploration of the role of hypothalamic GABAergic neurons in metabolic regulation. Emerging research has uncovered key mechanisms through which these neurons modulate energy balance and maintain metabolic balance. These findings not only enhance our understanding of obesity and related metabolic disorders but also underscore the link between hypothalamic dysfunction and prevalent metabolic diseases such as obesity and type 2 diabetes. This review summarizes the latest advancements in our understanding of the role of hypothalamic GABAergic neurons in metabolic regulation. It aims to elucidate the neural and molecular mechanisms underlying hypothalamic control of metabolism, offering new perspectives for the diagnosis and treatment of metabolic disorders.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1551741"},"PeriodicalIF":3.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dual residual risk of cholesterol and inflammation on adult male sex hormones: a cross-sectional study from NHANES.","authors":"Yang Zhou, Guofeng Wang, Li Liu, Jie Yu, Shiying Ju","doi":"10.3389/fendo.2025.1526056","DOIUrl":"10.3389/fendo.2025.1526056","url":null,"abstract":"<p><strong>Purpose: </strong>Sex hormones are closely linked to inflammation and lipid metabolism. This study explores the correlation of residual cholesterol risk and residual inflammation risk with sex hormones.</p><p><strong>Materials and methods: </strong>Logistic regression and dose-response curve analyses were conducted to examine the associations of total testosterone (TT), Sex Hormone Binding Protein (SHBG), Estradiol (E2), and Free testosterone (FT) with low density lipoprotein cholesterol (LDL-C) and high sensitive c-reactive protein (hs-CRP). Testosterone deficiency, defined as TT below 300 ng/dL, was analyzed across various subgroups based on LDL-C and hs-CRP levels. Grouped by LDL-C and hs-CRP: normal, LDL-C < 2.6 mmol/L, hs-CRP < 3mg/L, residual cholesterol risk only (RCR): LDL-C ≥ 2.6 mmol/L, hs-CRP < 3mg/L, residual inflammation risk only (RIR): LDL-C < 2.6 mmol/L. hs-CRP ≥ 3mg/L, both risk (BR): LDL-C ≥ 2.6 mmol/L, hs-CRP ≥ 3mg/L.</p><p><strong>Results: </strong>The results indicated a negative association between hs-CRP and TT (β = -1.98, 95% CI [-3.54, -0.42], p = 0.013), as well as FT (β = -0.04, 95% CI [-0.07, -0.02], p = 0.0002). Similar trends were observed for the relationship between hs-CRP and SHBG (β = -3.61, 95% CI [-5.33, -1.90], p = 0.0003). In the presence of both risk factors (BR), TT decreased most significantly (β = -79.37, 95% CI [-112.74, -46.00], p < 0.0001), as did FT in the same subgroup (β = -1.00, 95% CI [-1.61, -0.40], p = 0.0012). Notably, hs-CRP exhibited a non-linear correlation with TT, SHBG, and FT, with distinct inflection points. Furthermore, in diabetic patients, hs-CRP was positively linked to E2 (β = 0.39, 95% CI [0.03, 0.74], p = 0.0328).</p><p><strong>Conclusions: </strong>LDL-C was independently correlated with SHBG, hs-CRP with TT and FT, and the BR population had a higher risk of testosterone deficiency. Special populations with diabetes and hypertension need to be concerned about residual cholesterol risk and inflammatory risk.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1526056"},"PeriodicalIF":3.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the pathogenesis of endometriosis-related infertility based on contemporary evidence.","authors":"Qing Qi, Yaonan Li, Ziqin Chen, Zhihui Luo, Ting Zhou, Jing Zhou, Yanlin Zhang, Song Chen, Ling Wang","doi":"10.3389/fendo.2025.1558271","DOIUrl":"10.3389/fendo.2025.1558271","url":null,"abstract":"<p><p>Endometriosis, the most prevalent cause of infertility, is associated with anatomical distortion leading to adhesions and fibrosis, as well as endocrine abnormalities and immune disorders. This review discusses the mechanisms underlying endometriosis-related infertility. Firstly, alterations in the hypothalamic-pituitary-ovarian axis lead to the secretion of gonadotropins and steroid hormones, with adverse effects on ovulation and implantation, leading to fertility decline. Secondly, dysregulation of the hypothalamic-pituitary-adrenal axis induces elevated serum cortisol and prolactin levels in patients with endometriosis, accounting for its regulation of stress, depression, and anxiety. Abnormal interactions between endometrial cells and the immune system change the local microenvironment, resulting in epithelial-mesenchymal transition and inflammation. Activated epithelial cells, stromal cells, and immunocytes produce various chemokines, cytokines, or autoantibodies, creating an unfavorable environment for embryo implantation. These findings suggest that alterations in the immune spectrum play a crucial role in endometriosis-related infertility. Thirdly, oxidative stress has adverse effects on the ovarian reserve and subsequent embryonic development, predicting another promising strategy for endometriosis-related infertility. An unbalanced redox state, including impaired mitochondrial function, dysregulated lipid metabolism, and iron-induced oxidative stress, generates a pro-oxidative microenvironment, which negatively impacts oocyte quality and sperm and embryo viability. Thus, an updated understanding of the mechanisms involved in this disease will help to develop effective strategies to manage endometriosis-related infertility.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1558271"},"PeriodicalIF":3.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complexity of skeletal dysplasias in the national health system.","authors":"Dorra Najjar, Aleš Maver, Ana Peterlin, Helena Jaklič, Borut Peterlin","doi":"10.3389/fendo.2025.1523737","DOIUrl":"10.3389/fendo.2025.1523737","url":null,"abstract":"<p><strong>Introduction: </strong>Skeletal dysplasia (SD) is a large and heterogeneous group of rare genetic disorders that affects bone and cartilage growth. These disorders are diagnosed based on radiographic, clinical, and molecular criteria. However, the diagnostics is challenging due to clinical and genetic heterogeneity. We present the experience of systematic use of comprehensive genetic testing in the national health system and the molecular epidemiology of SD in Slovenia.</p><p><strong>Methods: </strong>We retrospectively reviewed 470 patients with clinical features of SD, including prenatal, childhood, and adult patients referred for diagnostic genetic evaluation to the national genetic reference center over ten years. In 262 patients, whole exome or whole genome sequencing was performed, while direct gene sequencing was performed in 208 patients with a specific clinical diagnosis.</p><p><strong>Results: </strong>A definitive genetic diagnosis using NGS was achieved in 50% (n=131) of patients. Among the positive cases, 49.61% initially presented with a nonspecific diagnosis of SD, and genetic testing contributed to establishing the diagnosis. Moreover, we demonstrated high genetic heterogeneity in our SD cohort with 66 distinct causative genes, resulting in different types of SD. In detail, we detected 132 causative variants, of which 29 were novel, which expanded the mutational spectrum of SD. Furthermore, pathogenic copy number variants (CNVs) were identified in 4.55% of the total number of variants, highlighting the importance of CNV analysis in expanding the yield of molecular diagnosis of SD.</p><p><strong>Conclusion: </strong>With the systematic use of WES and WGS, we have significantly improved the diagnostic yield of SD in the national health system and access to genetic testing. Moreover, we found significant genetic heterogeneity, and we report the genetic epidemiology of SD in the Slovenian population.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1523737"},"PeriodicalIF":3.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and prognostic analysis of patients with type 2 diabetic kidney disease and non-diabetic kidney disease.","authors":"Can Yu, Wen Shi, Enhui Chen, Yang Qiu, Li Gao, Hansheng Fang, Jun Ni, Dongrong Yu, De Jin","doi":"10.3389/fendo.2025.1493521","DOIUrl":"10.3389/fendo.2025.1493521","url":null,"abstract":"<p><strong>Background: </strong>In diabetic patients, non-diabetic kidney disease (NDKD) may occur independently or alongside diabetic kidney disease (DKD). This study explored the utility of kidney biopsy in type 2 diabetes mellitus (T2DM) patients and the predictability of diagnosing DKD combined with NDKD using clinical and laboratory data.</p><p><strong>Methods: </strong>This retrospective study examines medical records of T2DM patients who underwent percutaneous renal biopsy at Hangzhou TCM Hospital, Zhejiang Chinese Medical University, from 2012 to 2023. The patient's demographic, clinical, blood test and pathological examination data were retrieved from their medical records. Multivariate regression analysis evaluated predictive factors for NDKD superimposed on DKD (DKD+NDKD).</p><p><strong>Results: </strong>A total of 285 patients were analyzed. The average age at the time of renal biopsy was 53.26 ± 10.55 years. The duration of diabetes was 93.19 ± 70.78 months. Of the patient population, 35.44% (101/285) were diagnosed with DKD alone, while 64.56% (184/285) had DKD+NDKD. Immunoglobulin A nephropathy was the most common pathological type in the DKD+NDKD group, accounting for 37.30% of the patients. Cystatin C [HR=2.688, 95% CI 1.035-6.879, P < 0.05] independently predicted the prognosis of patients with DKD+NDKD.</p><p><strong>Conclusions: </strong>These findings suggest that cystatin C plays a role in influencing the prognosis of patients with DKD + NDKD, indicating that NDKD patients might require distinct treatment strategies compared to those with DKD alone. However, further prospective clinical trials are needed to provide more clarity on the prognosis and outcomes of diabetic patients.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1493521"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Parameters of 29994 sperm in a fertile male population-based on Papanicolaou staining and SSA-II Plus.","authors":"Longlong Fu, Fang Zhou, Guoping Chen, Renpei Yuan, Wenjie Li, Shi Qiu, Liang Tang, Wenshu Liu, Yiqun Gu, Wenhong Lu","doi":"10.3389/fendo.2025.1546290","DOIUrl":"10.3389/fendo.2025.1546290","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to provide reference data for sperm morphology in a healthy, fertile male population providing a foundation for future studies on male infertility assessment and sperm selection in assisted reproductive technologies.</p><p><strong>Methods: </strong>The study included 21 healthy male participants, all of whom had partners who conceived within the past 12 months. Sperm samples were collected according to WHO guidelines and stained using the Papanicolaou method. Sperm morphology parameters, including head length, width, area, perimeter, ellipticity, and acrosome area, were measured using the Suiplus SSA-II Computer-Assisted Sperm Analysis (CASA) system. Statistical comparisons were made between CASA and traditional manual methods.</p><p><strong>Results: </strong>The percentage of sperm with normal head morphology was 9.98%. Detailed sperm head measurements, including length, width, and area, were provided as reference values for the healthy male population. The CASA system demonstrated the ability to reduce subjective errors and showed no significant differences in sperm count and motility compared to traditional methods.</p><p><strong>Conclusion: </strong>This study provides precise sperm morphology reference values that enhance male infertility diagnostics and treatment, particularly in sperm selection for assisted reproductive technologies like ICSI.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1546290"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between advanced glycation end products, metabolic metrics, HbA_1c, and diabetic nephropathy.","authors":"Liping Xue, Yi Zhang, Qiu Zhang","doi":"10.3389/fendo.2025.1468737","DOIUrl":"10.3389/fendo.2025.1468737","url":null,"abstract":"<p><strong>Background: </strong>In this cross-sectional study, we aim to investigate the value of non-invasive advanced glycation end products (AGEs) detection in the early screening of diabetic nephropathy(DN) among individuals with type 2 diabetes mellitus and assess whether metabolic parameters and glycated hemoglobin A_1c (HbA_1c) can moderate this relationship.</p><p><strong>Methods: </strong>A total of 912 T2DM patients were enrolled. The urinary albumin-to-creatinine ratio (UACR) was measured in morning urine samples to assess DN. AGEs were non-invasively measured through skin autofluorescence. Recognizing the role of age in both AGEs and DN, AGE_age was calculated as AGEs × age/100 for related analyses.</p><p><strong>Results: </strong>The overall prevalence of DN in the present study was 37.2%. Elevated AGE_age(χ² = 61.06) was associated with a higher prevalence of DN. Multivariable linear regression demonstrated that AGE_age was positively associated with UACR levels(β = 0.154, 95% CI: 0.126, 0.306, P<0.001). In the moderation analysis, glycated hemoglobin A_1c (HbA_1c) affected the correlation between AGE_age and UACR. Body mass index (BMI) and triglyceride glucose-body mass index (TyG-BMI) also affect the correlation between AGE_age and UACR, there were significant interactions between AGE_age, HbA_1c, BMI, TyG-BMI, and UACR.</p><p><strong>Conclusions: </strong>Complex associations and interactions were observed between AGEs, metabolic metrics, HbA_1c, and DN. Implementing comprehensive interventions can potentially benefit the prevention of DN in T2DM patients.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1468737"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hs-CRP/HDL with type 2 diabetes mellitus in middle-aged and elderly people: a cross-sectional study from CHARLS.","authors":"Yan Jiang, Jiali Yu","doi":"10.3389/fendo.2025.1471292","DOIUrl":"10.3389/fendo.2025.1471292","url":null,"abstract":"<p><strong>Background: </strong>Research into the relationship between the ratio of high-sensitivity C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol (HDL-C) concerning type 2 diabetes mellitus (T2DM) is still scarce. The hs-CRP/HDL ratio could be an important biomarker for evaluating the risk of developing diabetes. This study primarily aims to investigate the association between hs-CRP/HDL ratios and the incidence of T2DM within a defined population.</p><p><strong>Methods: </strong>This analysis was conducted using data from 9,381 participants aged 45 and older, obtained during the 2011 wave of the China Health and Retirement Longitudinal Study (CHARLS). The study evaluated the association between the hs-CRP/HDL ratio and the risk of developing type 2 diabetes mellitus (T2DM) employing multivariate logistic regression, subgroup analyses, smooth curve fitting, and threshold effect analysis.</p><p><strong>Results: </strong>The overall prevalence of T2DM within the study population was found to be 16.3%, with 46.1% of cases occurring in men and 53.9% in women. Participants diagnosed with T2DM demonstrated a mean hs-CRP/HDL ratio that was 1.2 times higher than that of individuals without diabetes. The adjusted odds ratio (OR) for T2DM associated with hs-CRP/HDL levels was determined to be 0.75 (95% CI: 0.64-0.87). Additionally, a significant interaction was identified between hs-CRP/HDL ratios and variables such as sex and smoking in relation to T2DM risk (P < 0.05). Further subgroup analyses examining factors like age, education, marital status, hukou status, and drinking habits did not reveal any significant interactions (all P values for interaction were >0.05).</p><p><strong>Conclusions: </strong>The results highlight a robust association between the hs-CRP/HDL ratio and the likelihood of developing T2DM, indicating its potential as a predictive biomarker for the condition. Additional research is required to clarify the relationship between hs-CRP/HDL ratios and the incidence of T2DM.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1471292"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of novel nomograms based on the log odds of positive lymph nodes to predict the prognosis of papillary thyroid cancer: a retrospective cohort study.","authors":"Saisai Jing, Jiazhao Song, Yupeng Di, Jiajia Xiao, Jianke Ma, Zimiao Wu","doi":"10.3389/fendo.2025.1411426","DOIUrl":"10.3389/fendo.2025.1411426","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the long-term prognostic significance of the log odds of positive lymph nodes (LODDS) in patients diagnosed with papillary thyroid cancer (PTC) and to develop a novel nomogram for predicting long-term overall survival (OS).</p><p><strong>Methods: </strong>The cohort was randomly divided at a ratio of 7:3 from the Surveillance, Epidemiology, and End Results (SEER) database. Additionally, patient data from a medical center in China served as an external validation cohort. Nomograms were constructed using data from the training cohort and subsequently validated using both internal and external validation cohorts to predict 120- and 180-month OS in PTC patients. The predictive performance and clinical utility of the nomogram were assessed using various metrics, including the concordance index (C-index), time-dependent receiver operating characteristic (ROC) curves, calibration curves, decision curve analysis (DCA), Integrated Discriminant Improvement Index (IDI), and Net Reclassification Improvement Index (NRI).</p><p><strong>Results: </strong>LODDS is an independent prognostic factor for PTC, a nomogram demonstrating high accuracy in predicting long-term OS. The C-index values, and time-dependent area under the curve (AUC) indicated well discriminatory ability of the nomogram. Calibration plots exhibited high concordance, while DCA, NRI, and IDI analyses revealed superior performance of the nomogram compared to AJCC staging system.</p><p><strong>Conclusion: </strong>The clinical prediction model incorporating LODDS exhibits robust predictive performance, aiding in the assessment of long-term prognosis post-surgery in PTC patients. It serves as a valuable adjunct to the AJCC system, offering a scientific basis for guiding interventions and rehabilitation strategies for PTC patients following surgery.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1411426"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}