Frontiers in Endocrinology最新文献

{"title":"Atherogenic Index of Plasma mediates the association between Life's Crucial 9 with overactive bladder: a secondary data analysis from NHANES.","authors":"Hongyang Gong, Xiaomei Lin, Shaoqun Huang","doi":"10.3389/fendo.2025.1505712","DOIUrl":"https://doi.org/10.3389/fendo.2025.1505712","url":null,"abstract":"<p><strong>Background: </strong>Some studies suggest a potential link between cardiovascular health, lipid, and overactive bladder (OAB). Life's Crucial 9 (LC9) is a recently developed method for assessing cardiovascular health, while the Atherogenic Index of Plasma (AIP) represents a novel marker of atherosclerotic lipid profiles. However, the relationship between Life's Crucial 9 and overactive bladder and the role of Atherogenic Index of Plasma in the relationship between Life's Crucial 9 and overactive bladder is unclear. This study investigates the relationship between Life's Crucial 9 and overactive bladder and evaluates whether Atherogenic Index of Plasma influences this association.</p><p><strong>Methods: </strong>This study conducted a cross-sectional analysis of 25,628 U.S. participants in the NHANES database from 2005-2018. Firstly, we used multivariate logistic regression to investigate the relationship between Life's Crucial 9 and overactive bladder. Subsequently, subgroup analysis and restricted cubic splines (RCS) were further used to verify their relationship. Additionally, mediation analysis was conducted to explore the potential role of Atherogenic Index of Plasma levels in the association between Life's Crucial 9 and overactive bladder.</p><p><strong>Results: </strong>A total of 25,628 participants were included in this study, among whom 5,150 reported overactive bladder events. After using multivariate logistic regression to adjust for age, sex, race, marital status, education level, poverty-to-income ratio (PIR), smoking, alcohol consumption, hypertension, diabetes, and hypercholesterolemia, a 10-unit increase in Life's Crucial 9 was associated with a 28% reduction in overactive bladder incidence (OR = 0.72, 95% CI: 0.69-0.76), while a 1-unit increase in Atherogenic Index of Plasma was associated with a 7% increase in overactive bladder incidence (OR = 1.07, 95% CI: 1.01-1.14). Similar results were obtained when Life's Crucial 9 and Atherogenic Index of Plasma were categorized into tertiles, with a significant trend (P for trend < 0.05). Restricted cubic spline analysis revealed a linear negative correlation between Life's Crucial 9 and overactive bladder incidence. Mediation analysis further indicated that 6.49% of the relationship between Life's Crucial 9 and overactive bladder was mediated by Atherogenic Index of Plasma (P = 0.014).</p><p><strong>Conclusion: </strong>This study found a significant negative correlation between Life's Crucial 9 and overactive bladder, with Atherogenic Index of Plasma partially mediating this relationship. These findings highlight the potential link between cardiovascular health and overactive bladder, underscoring the role of Life's Crucial 9 in reducing overactive bladder incidence, possibly through its effects on lowering lipid levels.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1505712"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unyielding challenge for refractory hyponatremia in neuroendocrine cervix carcinoma: a case report.","authors":"Minzhen Li, Rutie Yin, Lan Zhong, Liang Song","doi":"10.3389/fendo.2025.1451157","DOIUrl":"https://doi.org/10.3389/fendo.2025.1451157","url":null,"abstract":"<p><p>Neuroendocrine neoplasms (NENs) originate from peptidergic neurons and neuroendocrine cells, possessing endocrine functions, and are commonly found in the gastrointestinal tract, pancreas, and lungs. Neuroendocrine cervix carcinoma (NECC) is infrequent, prone to early dissemination and distant metastasis, and generally has a poor prognosis. The presence of electrolyte imbalance in such cases is even rarer. Here, we present a case of advanced NECC patient who developed refractory hyponatremia, accompanied by severe clinical symptoms such as palpitations, chest tightness, hematemesis, and delirium. Despite extensive investigations, all efforts to elucidate the underlying causes of hyponatremia were negative, suggesting a multifactorial etiology. Next-generation sequencing was also employed to explore the underlying mechanisms at the genetic level. Managing this case posed significant challenges for gynecologic oncologists, as the patient showed minimal response to various treatments, including sodium supplementation, fluid restriction or replenishment, chemotherapy modification, and the use of vasopressin-2 receptor antagonist. This case underscores the importance of monitoring and managing electrolytes in patients with gynecologic NENs, even though the exact mechanisms of such imbalances may remain elusive.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1451157"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the island area also need to insist on salt iodization to prevent iodine deficiency disorders? a cross-sectional survey in Hainan Province, China.","authors":"Hongying Wu, Shizhu Meng, Dingwei Sun, Yuting Hu, Tingou Wu, Xiaohuan Wang, Xingren Wang, Ying Liu, Chuyan Peng, Bin He, Fangang Meng","doi":"10.3389/fendo.2025.1536506","DOIUrl":"https://doi.org/10.3389/fendo.2025.1536506","url":null,"abstract":"<p><strong>Background: </strong>To investigate the epidemiology and related factors of iodine deficiency disorders (IDD) in Hainan Province, to know the iodine nutrition status and thyroid disease status of residents, and to explore whether salt iodization should be adopted to prevent and control IDD in island areas. To provide a basis for the effective implementation of scientific iodine supplement prevention and control strategy.</p><p><strong>Methods: </strong>All 21 cities, counties (districts) in the province were investigated. Superficial soil, residential drinking water, common food, urine samples of children, adults and pregnant women, household salt samples, thyroid B-ultrasound of adults and pregnant women, adult blood samples were collected. Soil iodine, water iodine, food iodine, urine iodine, daily salt intake, salt iodine, thyroid volume, nodules and thyroid function were measured.</p><p><strong>Results: </strong>The median iodine content in soil was 4.37mg/kg, the median iodine content in drinking water was 6.0μg/L, the iodized salt coverage rate was 98.6%, and the consumption rate of qualified iodized salt was 97.9%. The median urinary iodine concentration (MUIC) in children and adults was 180.3μg/L and 151.6μg/L, respectively, which was the adequate level of iodine. The median urinary iodine in pregnant women was 144.6μg/L, which was slightly lower than the adequate level. The main source of iodine intake was salt iodine, which contributed 59.8% to total dietary iodine. Kelp, milk and seaweed, whose contribution rates were 8.2%, 7.3% and 6.6%, respectively. The total iodine contribution rate of other foods was 18.1%, among which the contribution rate of fish, shrimp and crabs was only 2.4%. The overall prevalence of thyroid diseases was 27.01%. The detection rates of subclinical hypothyroidism and subclinical hyperthyroidism in males were significantly higher than those in females, and the detection rates of thyroid nodules and goiter were significantly lower than those in females. The detection rates of thyroid nodules in central mountainous areas were significantly higher than those in eastern and western coastal areas.</p><p><strong>Conclusions: </strong>At present, the iodine nutrition level in Hainan Province is generally in a suitable state, and the iodine intake of residents mainly comes from iodized salt. The strategy of salt iodization prevention and control of IDD should be adhered to in island area.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1536506"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between ghrelin and thyroid disease: a meta-analysis.","authors":"Caihong Xin, Jiayi Yao, Huijuan Li, Xin Sun, Huijuan Wang","doi":"10.3389/fendo.2025.1505085","DOIUrl":"https://doi.org/10.3389/fendo.2025.1505085","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have identified a close relationship between ghrelin levels and thyroid disease. Ghrelin levels were lower in patients with hyperthyroidism compared with healthy individuals, and increased after treatment. However, other studies have reported inconsistent results. As such, the association between ghrelin and thyroid disease remains controversial.</p><p><strong>Methods: </strong>A literature search of the Web of Science, Wiley Online Library, Embase, and PubMed databases was performed. The title or abstract search term \"thyroid\" was used in combination with \"ghrelin\". Meta-analysis results are reported as standardized mean difference with corresponding 95% confidence interval (CI).</p><p><strong>Results: </strong>Twenty-three studies were included in this meta-analysis. Ghrelin levels in patients with hyperthyroidism were significantly lower than those in healthy individuals (SMD: -1.03, 95% CI [-1.75, 0.32]), but significantly higher after effective treatment (SMD: 0.77, 95% CI [0.03, 1.51]). Ghrelin levels were higher, but not significantly, in patients with hypothyroidism compared with healthy controls (SMD: 0.48, 95% CI [-0.13, 1.08]).</p><p><strong>Conclusions: </strong>This systematic review is the first to evaluate the relationship between ghrelin and thyroid disease. Determining the role of ghrelin in thyroid disease will significantly contribute to understand of symptom or pathomechanism.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42024591501.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1505085"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between life's crucial 9 and severe abdominal aortic calcification in U.S. Adults: the mediating role of the systemic inflammatory response index.","authors":"Kaifeng Tang, Linping Wang, Jinming Ye, Feng Yuan","doi":"10.3389/fendo.2025.1526114","DOIUrl":"https://doi.org/10.3389/fendo.2025.1526114","url":null,"abstract":"<p><strong>Background: </strong>Life's Crucial 9 (LC9) is an emerging cardiovascular health scoring system that incorporates Life's Essential 8 (LE8) alongside mental health factors. However, its relationship with severe abdominal aortic calcification (SAAC) remains poorly understood.</p><p><strong>Objectives: </strong>The objective of this study is to investigate the relationship between LC9 scores and the incidence of SAAC in the US population.</p><p><strong>Methods: </strong>Data from 2,323 participants were analyzed, originating from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) cycle. In exploring the dynamics of LC9, its constituents, and their relationship with SAAC, we employed advanced statistical methodologies, specifically multivariable logistic regression and weighted quantile sum regression. Subgroup interaction analyses were conducted to reinforce the conclusions, and mediation analysis was employed to investigate how the systemic inflammatory response index (SIRI) influences the connection between LC9 and SAAC.</p><p><strong>Results: </strong>In fully adjusted models, an increase of 10 points in LC9 scores was associated with a 26% reduction in the prevalence of SAAC, achieving statistical significance (<i>P</i> < 0.001). As LC9 scores increased, a significant decline in SAAC prevalence was noted (<i>P</i> < 0.05). The WQS analysis pinpointed strong links between the occurrence of SAAC and variables including exposure to tobacco, blood pressure levels, blood glucose concentrations, and mental health status, the odds ratio stood at 0.244, with the 95% CI extending from 0.119 to 0.495. SIRI was positively correlated with SAAC (<i>P</i> < 0.05) and decreased with rising LC9 scores (β = -0.09, <i>P</i> < 0.001). Mediation analysis revealed that the SIRI significantly influenced the linkage between LC9 and SAAC, accounting for 5.8% of the mediation effect, with a statistically significant p-value (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>This research highlights a robust inverse relationship between elevated LC9 scores and reduced SAAC incidence, suggesting the significant role of LC9 as a key factor in diminishing the frequency of SAAC. Furthermore, SIRI mediates this relationship.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1526114"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The crucial role of hypertension in determining latent classes of metabolic syndrome in northern Iran and predictive power of these classes in non-alcoholic fatty liver: a gender-based insight.","authors":"Bahareh Amirkalali, Parvin Hassanzadeh, Fatemeh Sheikholmolooki, Esmaeel Gholizadeh, Azam Doustmohammadian, Fahimeh Safarnezhad Tameshkel, Nima Motamed, Mansooreh Maadi, Masoudreza Sohrabi, Elham Sobhrakhshankhah, Farhad Zamani, Hossein Ajdarkosh","doi":"10.3389/fendo.2025.1405833","DOIUrl":"https://doi.org/10.3389/fendo.2025.1405833","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the subclasses of metabolic syndrome (Mets) and their relationship with non-alcoholic fatty liver (NAFLD) and the probable predictive role of serum vitamin D and CRP levels.</p><p><strong>Methods: </strong>This community-based, cross-sectional study was performed on adults in the framework of the Amol cohort prospective study (AmolCPS). Mets was defined as Adult Treatment Panel III criteria (ATP III) and ultrasound was used to diagnose NAFLD. Anthropometric and blood pressure measurements were conducted, and biochemical measurements were assessed after fasting. Data analysis included Latent class analysis, two-tailed χ2 statistics, one-way analysis of variance, and logistic regression using Mplus (version 7.4) and spss (version 26) softwares.</p><p><strong>Results: </strong>The study involved 2308 participants, with a mean age of 43.17 ± 12.30 years. Mets prevalence was 25.64%, with three identified classes: Mets with Hypertension (HTN), Mets without HTN (Non-HTN), and Low Risk. Mets with HTN had a high probability of at least four components, particularly high SBP. Non-HTN had at least three high probable components, especially high TG and low HDL but not high SBP and DBP. The low-risk class had a low probability of all components except low HDL in women. Serum vitamin D and CRP levels did not significantly predict Mets classes in men, while CRP level significantly predicted the HTN class in women (OR:1.03, CI:1.004-1.067). Both HTN, and Non-HTN Mets classes significantly increased the odds of NAFLD compared to the low risk class, especially in women (HTN class OR: 4.20 vs 2.94; non-HTN class OR: 5.60 vs 3.12 in women and men respectively).</p><p><strong>Conclusion: </strong>The latent class analysis in northern Iran identified three Mets classes: HTN, Non-HTN, and low-risk, with hypertension playing a crucial role in determining these classes. These classes were stronger predictors of NAFLD in women. Serum CRP and vitamin D levels did not emerge as significant predictors of the classes, except for serum CRP in the HTN class among women.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1405833"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular disease mortality in patients with type 2 diabetes mellitus and diabetic kidney disease.","authors":"Zhiyu Li, Hongyang Xu","doi":"10.3389/fendo.2025.1509752","DOIUrl":"https://doi.org/10.3389/fendo.2025.1509752","url":null,"abstract":"<p><strong>Purpose: </strong>Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) represents an essential lipid index and is closely related to the occurrence and development of diabetes and cardiovascular diseases (CVDs). Therefore, this study is intended to further investigate the association between the NHHR index and the mortality rate of CVDs in patients with type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD).</p><p><strong>Methods: </strong>The research sample was selected from the NHANES (National Health and Nutrition Examination Survey) database, and 5136 individuals were categorized based on quartiles of the NHHR index. Restricted cubic plots and COX regression models were utilized to examine the thresholds and patterns of the NHHR index in relation to the risk of CVDs mortality among T2DM patients as well as those with DKD. Subgroup analyses and p-values were used to evaluate interactions between different variables.</p><p><strong>Results: </strong>The NHHR index shows a nonlinear association with cardiovascular mortality in two patient groups, following an L-shaped pattern. In individuals with T2DM, a lower NHHR index (<1.68) correlates with an increased risk of death, demonstrating a 72.8% reduction in mortality risk for each unit increase in NHHR below this threshold. Similarly, among patients with DKD, a lower NHHR index (<1.82) is associated with heightened cardiovascular mortality risk, indicating a 48.2% reduction in death risk for each unit increase in NHHR beneath the specified threshold. In patients diagnosed with T2DM, the third quartile of the NHHR index was significantly linked to reduced mortality risk; the association remained consistent even when additional variables were considered [Hazard Ratio (HR), 0.82; 95% Confidence Interval (CI) (0.69-0.97); P=0.019]. Among patients with DKD, cardiovascular mortality was notably higher in the third and fourth quartiles of the NHHR index [Quartile3 HR, 1.57; 95% CI (1.10-2.24), P=0.013; Quartile4 HR, 2.04; 95% CI (1.28-3.26), P=0.003].</p><p><strong>Conclusions: </strong>The NHHR is below 1.68, and an increase in the NHHR index is associated with a reduced risk of CVD mortality in patients with T2DM. Similarly, when the NHHR falls below 1.82, an elevation in the NHHR index correlates with a decreased risk of CVD mortality in patients with DKD.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1509752"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography provides a \"one-stop-shop\" targeted analysis for coronary artery calcification and osteoporosis: a review.","authors":"Jing Luo, Qian Wang, Wenhong Liu, Huazhi Liao, Weipeng Qing, Minyi Zhang, Deqiu Tang, Guanghua Luo, Heng Zhao","doi":"10.3389/fendo.2025.1356831","DOIUrl":"https://doi.org/10.3389/fendo.2025.1356831","url":null,"abstract":"<p><p>The global trend towards longer lifespans has led to an aging population and a rise in the prevalence of diseases that predominantly affect elderly people. Coronary artery calcification (CAC) and osteoporosis (OP) are common in elderly populations. CT scans provide a reliable method to assess and monitor the progression of these diseases. In this review, the relationship between OP and CAC in terms of pathophysiological mechanism, comorbidity risk factors and clinical manifestations is reviewed, with a focus on the advancements in CT imaging, clinical applications and the possibility for \"one-stop-shop\" for examination.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1356831"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Xiangshao granules on clinical symptoms and serum hormone levels of menopausal syndrome: a systematic review and meta-analysis of randomized controlled trials.","authors":"Xing Tang, Chengcheng Wang, Yang Liu, Yisha Xu, Shoujin Dong, Min Dai, Chunmei Li, Yan Zhai, Shoujen Lan, Yeayin Yen, Chao Wang, Congcong Yu","doi":"10.3389/fendo.2025.1546200","DOIUrl":"https://doi.org/10.3389/fendo.2025.1546200","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the efficacy and safety of Xiangshao granules in improving clinical symptoms and regulating serum hormone levels in patients with menopausal syndrome (MPS).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study was developed according to the PRISMA 2020 guidelines. Eight databases including PubMed, Web of Science, The Cochrane Library, Embase, CNKI, CBM, Wanfang Database, and VIP database were searched for randomized controlled trials (RCTs) of Xiangshao Granules in the treatment of MPS. The search time was from the listing of Xiangshao Granules (2005) to September 1, 2024. Xiangshao granule was used in experimental group. The control group was treated with placebo, other Chinese patent medicine, or conventional western medicine. The treatment period should be at least 4 weeks. RevMan5.4 was used for bias risk assessment and meta-analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 13 randomized controlled trials with 1637 participants were included. The meta-analysis showed that there was statistical significance between Xiangshao granules and control group in improving clinical symptoms (P&lt;0.05). Xiangshao granules could improve the total response rate (OR= 2.78, 95%CI[1.65, 4,68], P&lt;0.05) and reduce Kupperman score (MD=-1.23, 95%CI[-2.10,-0.36], P&lt;0.05). In addition, Xiangshao granules also decreased HAMD score (MD= -2.80, 95%CI[-3.54, -2.07], P&lt;0.05) and HAMA score (MD=-2.52, 95%CI[-3.00,-2.04], P&lt;0.05). In terms of serum hormone levels, there was no significant difference in serum FSH levels between Xiangshao granule group and control group(SMD=-0.81, 95%CI[-2.03, 0.41], P= 0.19). However, the regulating effect of Xiangshao granules on serum LH and E2 levels was statistically significant compared with the control group (P&lt;0.05). The results of subgroup analysis showed that Xiangshao granules were better than other Chinese patent medicines in reducing serum LH levels (SMD=-1.20, 95%C[-1.66,-0.73]I, P&lt;0.05). Xiangshao granules were superior to other Chinese patent medicines or placebo in increasing serum E2 levels (SMD=5.28, 95%CI[4.90, 5.66], P&lt;0.05) (SMD=2.00, 95%CI[1.10, 2.90], P&lt;0.05). Furthermore, the combined use of western medicine and Xiangshao granules was better than HRT or SSRIs alone in reducing serum LH level and increasing serum E2 level (P&lt;0.05). In terms of safety, there was no significant difference in the incidence of adverse reactions among all groups (OR= 1.28, 95%CI[0.80, 2.05], P = 0.31).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Xiangshao Granules can effectively relieve the clinical symptoms of MPS patients, improve the scores of anxiety and depression and regulate the level of serum estrogen, with good safety, and is an ideal treatment plan. In the future, multi-center and large sample randomized controlled trials can be conducted for more key clinical indicators to comprehensively analyze the clinical efficacy and applicability of Xiangshao granules in the treatment of MPS.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Syste","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1546200"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound radiomics and genomics improve the diagnosis of cytologically indeterminate thyroid nodules.","authors":"Lu Chen, Mingbo Zhang, Yukun Luo","doi":"10.3389/fendo.2025.1529948","DOIUrl":"https://doi.org/10.3389/fendo.2025.1529948","url":null,"abstract":"<p><strong>Background: </strong>Increasing numbers of cytologically indeterminate thyroid nodules (ITNs) present challenges for preoperative diagnosis, often leading to unnecessary diagnostic surgical procedures for nodules that prove benign. Research in ultrasound radiomics and genomic testing leverages high-throughput data and image or sequence algorithms to establish assisted models or testing panels for ITN diagnosis. Many radiomics models now demonstrate diagnostic accuracy above 80% and sensitivity over 90%, surpassing the performance of less experienced radiologists and, in some cases, matching the accuracy of experienced radiologists. Molecular testing panels have helped clinicians achieve accurate diagnoses of ITNs, preventing unnecessary diagnostic surgical procedures in 42%-61% of patients with benign nodules.</p><p><strong>Objective: </strong>In this review, we examined studies on ultrasound radiomics and genomic molecular testing for cytological ITNs conducted over the past 5 years, aiming to provide insights for researchers focused on improving ITN diagnosis.</p><p><strong>Conclusion: </strong>Radiomics models and molecular testing have enhanced diagnostic accuracy before surgery and reduced unnecessary diagnostic surgical procedures for ITN patients.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1529948"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}