Frontiers in Endocrinology最新文献

{"title":"Myokines as potential mediators of changes in glucose homeostasis and muscle mass after bariatric surgery.","authors":"Laura Orioli, Jean-Paul Thissen","doi":"10.3389/fendo.2025.1554617","DOIUrl":"https://doi.org/10.3389/fendo.2025.1554617","url":null,"abstract":"<p><p>Myokines are bioactive peptides released by skeletal muscle. Myokines exert auto-, para-, or endocrine effects, enabling them to regulate many aspects of metabolism in various tissues. However, the contribution of myokines to the dramatic changes in glucose homeostasis and muscle mass induced by bariatric surgery has not been established. Our review highlights that myokines such as brain-derived neurotrophic factor (BDNF), meteorin-like protein (Metrnl), secreted protein acidic and rich in cysteine (SPARC), apelin (APLN) and myostatin (MSTN) may mediate changes in glucose homeostasis and muscle mass after bariatric surgery. Our review also identifies myonectin as an interesting candidate for future studies, as this myokine may regulate lipid metabolism and muscle mass after bariatric surgery. These myokines may provide novel therapeutic targets and biomarkers for obesity, type 2 diabetes and sarcopenia.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1554617"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Diagnosis, prevention and treatment in diabetic nephropathy, volume III.","authors":"Maria Margherita Rando, Federico Biscetti, Andrea Flex","doi":"10.3389/fendo.2025.1586022","DOIUrl":"https://doi.org/10.3389/fendo.2025.1586022","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1586022"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning.","authors":"Qiao Tang, Yanwei Ji, Zhongyuan Xia, Yuxi Zhang, Chong Dong, Qian Sun, Shaoqing Lei","doi":"10.3389/fendo.2025.1478139","DOIUrl":"https://doi.org/10.3389/fendo.2025.1478139","url":null,"abstract":"<p><strong>Background: </strong>Diabetic cardiomyopathy (DC) is a serious complication in patients with type 1 diabetes mellitus and has become a growing public health problem worldwide. There is evidence that endoplasmic reticulum stress (ERS) is involved in the pathogenesis of DC, and related diagnostic markers have not been well-studied. Therefore, this study aimed to screen ERS-related genes (ERGs) with potential diagnostic value in DC.</p><p><strong>Methods: </strong>Gene expression data on DC were downloaded from the GEO database, and ERGs were obtained from The Gene Ontology knowledgebase. Limma package analyzed differentially expressed genes (DEGs) in the DC and control groups, and then integrated with ERGs to identify ERS-related DEGs (ERDEGs). The ERDEGs diagnostic model was developed based on a combination of LASSO and Random Forest approaches, and the diagnostic performance was evaluated by the area under the receiver operating characteristic curve (ROC-AUC) and validated against external datasets. In addition, the association of the signature genes with immune infiltration was analyzed using the CIBERSORT algorithm and the Spearman correlation test.</p><p><strong>Results: </strong>Gene expression data on DC were downloaded from the GEO database and ERGs were obtained from the Gene Ontology Knowledgebase. Limma package analysis identified 3100 DEGs between DC and control groups and then integrated with ERGs to identify 65 ERDEGs. Four diagnostic markers, Npm1, Jkamp, Get4, and Lpcat3, were obtained based on the combination of LASSO and random forest approach, and their ROC-AUCs were 0.9112, 0.9349, 0.8994, and 0.8639, respectively, which proved their diagnostic potential in DC. Meanwhile, Npm1, Jkamp, Get4, and Lpcat3 were validated by external datasets and a mouse model of type 1 DC. In addition, Npm1 was significantly negatively correlated with plasma cells, activated natural killer cells, or quiescent mast cells, whereas Get4 was significantly positively correlated with quiescent natural killer cells and significantly negatively correlated with activated natural killer cells (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>This study provides novel diagnostic biomarkers (Npm1, Jkamp, Get4, and Lpcat3) for DC from the perspective of ERS, which provides new insights into the development of new targets for individualized treatment of type 1 diabetic cardiomyopathy.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1478139"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncocytic pituicytoma in a patient with Cushing's disease: a case report and narrative literature review.","authors":"Jing Li, Shuaiming Chen, Huiwen Tan, Yerong Yu, Ying Tang, Bowen Cai, Jianwei Li","doi":"10.3389/fendo.2025.1487120","DOIUrl":"https://doi.org/10.3389/fendo.2025.1487120","url":null,"abstract":"<p><strong>Background: </strong>Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the World Health Organization (WHO) classified four types of tumors originating from the posterior pituitary: traditional pituicytoma, oncocytic pituicytoma, granular pituicytoma, and ependymal pituicytoma. To our knowledge, only one subject with coexistence of Cushing's disease and oncocytic pituicytoma (spindle cell oncocytoma) has been reported, but the clinical features of this patient were not described in detail.</p><p><strong>Case presentation: </strong>We presented a case of a patient with Cushing's syndrome and a pituitary mass. Transsphenoidal surgery was performed, and pathologic examination revealed two distinct tumors: a corticotroph adenoma with a diameter of less than 2 mm and a larger oncocytic pituicytoma. Post-surgery serum cortisol was 51 nmol/L, indicating complete remission. Corticotroph adenoma or corticotroph hyperplasia was identified after surgery in less than half of the subjects with Cushing's disease and PPT.</p><p><strong>Conclusions: </strong>Our study indicates that Cushing's disease in patients with PPT may be caused by the existence of collision lesions, with corticotroph adenoma or hyperplasia being difficult to detect due to their small dimensions.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1487120"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infertility management in resistant ovary syndrome: a review.","authors":"Hong Yi, Lin Chen, Jinglei Zhang, Yangxing Wen, Xi Zheng, Xiaoyan Chen","doi":"10.3389/fendo.2025.1560981","DOIUrl":"https://doi.org/10.3389/fendo.2025.1560981","url":null,"abstract":"<p><p>Resistant ovary syndrome is a rare endocrinological disorder characterized by elevated serum gonadotropins and normal ovarian reserves. The leading causes of this condition include <i>FSHR</i> mutations, and autoimmune disorders. Due to follicle maturation defects and anovulation, these patients have menstrual disturbances and infertility. Endocrinological disorders can be treated by regular hormone replacement therapy. However, there is no consensus regarding the infertility issues and current treatment remains experimental with controlled ovarian stimulation (COS) and <i>in vitro</i> maturation. Herein, we conducted a review of the current literature, which concludes that: 1) patients with <i>FSHR</i> mutations had very poor COS outcomes; 2) follicle-stimulating hormone and luteinizing hormone levels poorly predict COS outcomes; 3) both recombinant and urinary gonadotropins may be effective in COS; 4) the dosage of exogenous gonadotropins is not the key to successful COS; 5) <i>in vitro</i> maturation is a feasible option for patients carrying <i>FSHR</i> mutations or unsuccessful COS cycles.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1560981"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical skin conductance: a tool for risk stratification and early anticipation of diabetic foot ulcers.","authors":"Jean-François Gautier, Jean-Pierre Riveline, Louis Potier, Olivier Bourron, Lyse Bordier, Benjamin Vittrant, Ronan Roussel, Bernard Bauduceau","doi":"10.3389/fendo.2025.1437858","DOIUrl":"10.3389/fendo.2025.1437858","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic foot ulcers (DFUs) are a major complication of diabetes, leading to high morbidity, mortality, and healthcare costs. Current DFU risk stratification relies on clinical examination, which can be subjective. Electrochemical Skin Conductance (ESC), measured via Sudoscan, offers an objective assessment of small fiber dysfunction. This study evaluates the association between ESC and DFU risk stratification.</p><p><strong>Methods: </strong>A retrospective analysis of 2,157 diabetic patients from four tertiary centers in France was conducted. DFU risk was classified using the 2016 International Working Group on Diabetic Foot (IWGDF) grading system. ESC measurements were analyzed alongside age, sex, diabetes type, and monofilament test results. Regression and ROC analyses assessed predictive performance.</p><p><strong>Results: </strong>ESC values correlated with DFU grades (p<0.001), with lower foot ESC (FESC) in higher-risk patients. ROC analysis showed strong predictive value for severe DFUs (AUC = 0.82 for grade 3) but limited performance for early stages. Notably, ESC identified at-risk patients within grade 0, undetected by standard classification.</p><p><strong>Discussion: </strong>ESC provides a reproducible, operator-independent tool for DFU risk assessment, improving early detection beyond monofilament testing. These findings support its potential role in DFU prevention, reducing amputations and enhancing patient outcomes. Further studies are needed to validate its prognostic value and integration into clinical care.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1437858"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GBDKVA score: a scoring system for preoperative risk assessment of adrenal tumors ≤6cm.","authors":"Siwei Yang, Xianrui Yang, Zhili Yao, Qi Guo, Zekai Hou, Chenyu Wang, Ronghao Cui, Zhun Wang, Gang Li, Changyi Quan, Yuanjie Niu, Yan Zhao, Shaosan Kang, Qiliang Cai","doi":"10.3389/fendo.2025.1418535","DOIUrl":"10.3389/fendo.2025.1418535","url":null,"abstract":"<p><strong>Objectives: </strong>To propose a comprehensive scoring system for adrenal tumors ≤ 6cm and evaluate its rationality and validity.</p><p><strong>Materials and methods: </strong>This study retrospectively analyzed 268 patients with primary adrenal tumors who underwent laparoscopic surgery from January 2018 to December 2022 and all of them met the inclusion criteria. Evaluation scores were calculated for gender (G), body mass index (BMI) (B), tumor diameter (D), the relative position of the tumor to the kidney (K), the relative position of the tumor and the blood vessels (V) and the tumor location in the adrenal gland (A). Then, the total scores were correlated with the operation results, so as to verify the feasibility of GBDKVA in evaluating the surgical risk.</p><p><strong>Results: </strong>The GBDKVA score showed a consistent and statistically significant correlation with operation time (OT) and blood loss (BL), as well as a correlation with postoperative complications in patients (p < 0.01), but no significant correlation was found with recovery time of gastrointestinal function, bed rest days, indwelling drainage tube days and postoperative hospitalization time were opposite.</p><p><strong>Conclusions: </strong>GBDKVA score is reliable for preoperative risk assessment of patients with adrenal tumors ≤6cm.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1418535"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: NAFLD treatment in diabetes: from current dietary interventions to novel treatment.","authors":"Riccardo Nevola, Giuseppina Costabile, Giuseppe Della Pepa","doi":"10.3389/fendo.2025.1572770","DOIUrl":"https://doi.org/10.3389/fendo.2025.1572770","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1572770"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of GIPR in food intake control.","authors":"Paula-Peace James-Okoro, Jo Edward Lewis, Fiona Mary Gribble, Frank Reimann","doi":"10.3389/fendo.2025.1532076","DOIUrl":"10.3389/fendo.2025.1532076","url":null,"abstract":"<p><p>Glucose-dependent insulinotropic polypeptide (GIP) is one of two incretin hormones playing key roles in the control of food intake, nutrient assimilation, insulin secretion and whole-body metabolism. Recent pharmacological advances and clinical trials show that unimolecular co-agonists that target the receptors for the incretins - GIP and glucagon-like peptide 1 (GLP-1) - offer more effective treatment strategies for obesity and type 2 diabetes mellitus (T2D) compared with GLP-1 receptor (GLP1R) agonists alone, suggesting previously underappreciated roles of GIP in regulating food intake and body weight. The mechanisms by which GIP regulates energy balance remain controversial as both agonism and antagonism of the GIP receptor (GIPR) produce weight loss and improve metabolic outcomes in preclinical models. Recent studies have shown that GIPR signalling in the central nervous system (CNS), especially in regions of the brain that regulate energy balance, is essential for its action on appetite regulation. This finding has sparked interest in understanding the mechanisms by which GIP engages brain circuits to reduce food intake and body weight. In this review, we present key knowledge around the actions of GIP on food intake regulation and the potential mechanisms by which GIPR and GIPR/GLP1R agonists may regulate energy balance.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1532076"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMI trajectories among children diagnosed with type 1 diabetes mellitus at a tertiary diabetes center.","authors":"Reem Abdullah Al Khalifah, Noor Salem Bawahab, Raghad Wadea, Hala Gasim, Alhanouf Alrashed, Muneera Al-Jelaify, Bayan Alnassir, Eman Ragab Saleh, Iman Al-Gadi","doi":"10.3389/fendo.2025.1537860","DOIUrl":"10.3389/fendo.2025.1537860","url":null,"abstract":"<p><strong>Objective: </strong>The incidence of type 1 diabetes mellitus (T1DM) has increased worldwide, raising concerns about the intersection between T1DM and the rising prevalence of childhood obesity. This study investigates secular trends in body mass index (BMI) at T1DM diagnosis and its trajectory post-diagnosis, focusing on predictors of obesity persistence.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at a tertiary diabetes center in Riyadh, Saudi Arabia, between January 2015 and December 2023. Children under 14 years diagnosed with T1DM at the center were included, while those diagnosed elsewhere or with other diabetes types were excluded. Data included demographics, BMI z-scores based on Saudi and CDC growth charts, HbA1c levels, and clinical presentations like diabetic ketoacidosis (DKA). Linear regression assessed secular trends and predictors of baseline BMI z-scores.</p><p><strong>Results: </strong>Among 1160 screened children's charts, 408(35.17%) children met inclusion criteria. At diagnosis, mean age was 7.87 ± 3.53 years, with 161 (39.5%) presenting with DKA. The mean baseline BMI was 16.06 ± 3.62 kg/m², and BMI z-scores were -0.22 ± 1.65 (Saudi growth references) and -0.87 ± 1.92 (CDC growth references). No significant secular trends in BMI z-scores, gender, or DKA presentation were observed. Of 59(14.46%) children with baseline overweight/obesity, 46 (77.97%) remained overweight/obese at follow-up (p<0.001). The mean BMI z-score increased to 1.14± 1.64 at follow-up, with 113(27.70%) meeting overweight/obesity criteria.</p><p><strong>Conclusion: </strong>Overweight/obesity at diagnosis with T1DM persists at follow-up. Addressing obesity at T1DM diagnosis is crucial for mitigating its long-term metabolic impact. Future research should target interventions addressing lifestyle factors contributing to obesity in children with T1DM.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1537860"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}