Frontiers in Endocrinology最新文献

{"title":"Response: Commentary: Azathioprine as an adjuvant therapy in severe Graves' disease: a randomized controlled open-label clinical trial.","authors":"Magdy Mohamed Allam, Ramy Mohamed Ghazy, Hanaa Tarek Hussein Elzawawy","doi":"10.3389/fendo.2024.1473224","DOIUrl":"https://doi.org/10.3389/fendo.2024.1473224","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1473224"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram model to predict the high risk of lower live birth probability in young women undergoing the first IVF-ET cycle: a retrospective study.","authors":"Chang Liu, Peipei Pan, Beihai Li, Yili Teng","doi":"10.3389/fendo.2024.1401385","DOIUrl":"10.3389/fendo.2024.1401385","url":null,"abstract":"<p><strong>Objective: </strong>To build a prediction nomogram for early prediction of live birth probabilities according to number of oocytes retrieved in women ≤ 35 years of age.</p><p><strong>Methods: </strong>A prediction model was built including 9265 infertile women ≤ 35 years of age accepting their first ovum pick-up cycle from January 2018 to December 2022. Least absolute shrinkage and selection operator (LASSO) regression was performed to identify independent predictors and establish a nomogram to predict reproductive outcomes. Both discrimination and calibration were assessed by bootstrapping with 1000 resamples.</p><p><strong>Results: </strong>The critical threshold for the number of retrieved oocytes associated with cumulative live birth was determined as 10.5 (AUC: 0.824). Consequently, a nomogram was constructed to predict the likelihood of obtaining fewer than 10 oocytes at one oocyte retrieval cycle. There were five indicators significantly related to the risk of obtaining less than 10 oocytes at one oocyte retrieval cycle, including age, antral follicle count (AFC), anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), and FSH to luteinizing hormone ratio. These factors were subsequently used to develop a nomogram prediction model. The model's performance was evaluated using the area under the curve (AUC), concordance index (C-index), and calibration curves, which indicated fair predictive ability and good calibration.</p><p><strong>Conclusion: </strong>We developed and validated a nomogram based on five ovarian reserve indicators to predict the risk of retrieving fewer than 10 oocytes at one oocyte retrieval cycle in women ≤ 35 years of age. The model demonstrated good discrimination and calibration, indicating its reliability for clinical application. This nomogram offers a practical and accurate tool for early identification of young women with potentially decreased ovarian reserve, enabling timely intervention and personalized management strategies.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1401385"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the MDM-score system for screening mitochondrial diabetes mellitus in newly diagnosed diabetes patients: a multi-center cohort study in China.","authors":"Fuhui Ma, Jing Zhao, Yan Chen, Yunzhi Luo, Yuxuan Du, Xia Li, Tao Xu, Zhiguang Zhou, Kaixin Zhou, Yanying Guo","doi":"10.3389/fendo.2024.1511101","DOIUrl":"10.3389/fendo.2024.1511101","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance of MDM-score system in screening for mitochondrial diabetes mellitus (MDM) with m.3243A>G mutation in newly diagnosed diabetes.</p><p><strong>Methods: </strong>From 2015 to 2017, we recruited 5130 newly diagnosed diabetes patients distributed in 46 hospitals in China. Their DNA samples were subjected to targeted sequencing of 37 genes, including the mitochondrial m.3243A>G mutation. Based on this cohort, we analyzed the clinical characteristics of MDM and type 2 diabetes (T2DM), and evaluated the overall efficacy of the MDM-score through ROC curve analysis.</p><p><strong>Results: </strong>MDM patients were diagnosed at a younger age (<i>P</i> =0.002) than T2DM patients. They also had a higher proportion of females, lower body mass index, lower height, lower weight, lower systolic blood pressure, and lower fasting C-peptide (<i>P</i> < 0.05). Among 48 MDM patients, the m.3243A>G heteroplasmy level was higher in MDM score ≥ 3 than in MDM score < 3 (<i>P</i> = 0.0281). There were 23 cases with MDM-score ≥ 3 in clinical T2DM, with an AUC of 0.612 (95% CI: 0.540-0.683, <i>P <</i>0.001) on ROC curve analysis, yielding sensitivity of 47.9%, specificity of 74.4%, positive predictive value of 1.9%, and negative predictive value of 99.3%. This suggests that almost half of MDM patients can be identified by the MDM score system.</p><p><strong>Conclusions: </strong>The MDM-score is effective for screening MDM in newly diagnosed clinical T2DM, and some metrics may help to improve its performance in the future, thereby assisting clinicians in identifying suitable patients for genetic testing, and preventing misdiagnosis and mismanagement of MDM patients.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1511101"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between vitamin D deficiency and gestational diabetes: a narrative review.","authors":"Caiqiong Lin, Haiwei Liu","doi":"10.3389/fendo.2024.1504930","DOIUrl":"10.3389/fendo.2024.1504930","url":null,"abstract":"<p><p>Vitamin D, often referred to as the \"sunshine vitamin,\" is an essential fat-soluble vitamin that plays a critical role in bone health and has been shown to improve insulin sensitivity and glucose tolerance. Vitamin D deficiency is prevalent among pregnant and pre-pregnancy women, which increases the risk of developing gestational diabetes mellitus (GDM), a common complication during pregnancy. Recent studies have explored various aspects of the relationship between vitamin D deficiency and GDM, including the mechanisms by which vitamin D affects glucose metabolism, the role of the vitamin D receptor gene, and the impact of routine vitamin D supplementation before and during pregnancy. This paper will review the current research progress in these areas.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1504930"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional characterization of novel compound heterozygous missense <i>SLC5A5</i> gene variants causing congenital dyshormonogenic hypothyroidism.","authors":"Gerardo Hernán Carro, Mariano Martín, Sofía Savy, Victoria Peyret, Romina Celeste Geysels, Francisco Andrés Montes, Carlos Eduardo Bernal Barquero, Valentina Ricci, María Eugenia Masnata, Ana María Masini-Repiso, Patricia Papendieck, Mariana Lorena Tellechea, Ana Elena Chiesa, Juan Pablo Nicola","doi":"10.3389/fendo.2024.1465176","DOIUrl":"10.3389/fendo.2024.1465176","url":null,"abstract":"<p><strong>Introduction: </strong>The sodium/iodide symporter (NIS) mediates active iodide accumulation in the thyroid follicular cell. Biallelic loss-of-function variants in the NIS-coding <i>SLC5A5</i> gene cause congenital dyshormonogenic hypothyroidism due to a defect in the accumulation of iodide, which is required for thyroid hormonogenesis.</p><p><strong>Objective: </strong>We aimed to identify, and if so to functionally characterize, novel pathogenic <i>SLC5A5</i> gene variants in a patient diagnosed with severe congenital dyshormonogenic hypothyroidism characterized by undetectable radioiodide accumulation in a eutopic thyroid gland, as well as in the salivary glands.</p><p><strong>Methods: </strong>The coding region of the <i>SLC5A5</i> gene was sequenced using whole-exome sequencing. In silico analysis and in vitro functional characterization of missense <i>SLC5A5</i> gene variants were performed.</p><p><strong>Results: </strong>Proposita's whole-exome sequencing revealed a novel pair of compound heterozygous missense variants in the <i>SLC5A5</i> gene, c.1,627G>A (p.G543R) and c.1,684T>A (p.L562M). The parents were heterozygous carriers of the variants as determined by Sanger sequencing of the <i>SLC5A5</i> gene. The p.G543R variant in the homozygous state has previously been associated with congenital hypothyroidism. The novel p.L562M variant was not reported in the Genome Aggregation Consortium dataset. In silico analysis of the pathogenic impact of the p.L562M variant yielded inconclusive results. Functional in vitro studies showed that the p.L562M variant reduces iodide accumulation due to defective expression of the mutant NIS protein at the plasma membrane. Notably, the aliphatic residue Leu at position 562 in the carboxy terminus of the protein, which is highly conserved in NIS orthologues, is required for NIS plasma membrane expression.</p><p><strong>Conclusions: </strong>We report novel compound heterozygous missense <i>SLC5A5</i> gene variants causing defective iodide accumulation, thus leading to congenital dyshormonogenic hypothyroidism.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1465176"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Mendelian randomization in thyroid diseases: a review.","authors":"Zhonghui Li, Ruohan Wang, Lili Liu, Zonghang Jia, Peng Zhou, Qingqing He","doi":"10.3389/fendo.2024.1472009","DOIUrl":"10.3389/fendo.2024.1472009","url":null,"abstract":"<p><p>Thyroid diseases are increasingly prevalent, posing significant challenges to patients' quality of life and placing substantial financial burdens on families and society. Despite these impacts, the underlying pathophysiology of many thyroid conditions remains poorly understood, complicating efforts in treatment, management, and prevention. Observational studies can identify associations between exposure variables and disease; however, they often struggle to account for confounding factors and reverse causation. Understanding disease occurrence, epidemiological trends, and clinical diagnosis, prevention, and treatment relies heavily on robust etiological research. Mendelian randomization, a method grounded in genetics and epidemiology, has been widely employed in studying the etiology of thyroid diseases, offering a solution to some of these challenges. This paper categorizes thyroid diseases into thyroid dysfunction and thyroid cancer, reviewing related Mendelian randomization studies. It further provides novel perspectives and approaches for investigating the mechanisms underlying thyroid diseases and designing intervention strategies.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1472009"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental cell models of insulin resistance: overview and appraisal.","authors":"Ying Yang, Ting-Ting Wang, Hu-Ai Xie, Ping Ping Hu, Pan Li","doi":"10.3389/fendo.2024.1469565","DOIUrl":"10.3389/fendo.2024.1469565","url":null,"abstract":"<p><p>Insulin resistance, a key factor in the development of type 2 diabetes mellitus (T2DM), is defined as a defect in insulin-mediated control of glucose metabolism in tissues such as liver, fat and muscle. Insulin resistance is a driving force behind various metabolic diseases, such as T2DM, hyperlipidemia, hypertension, coronary heart disease and fatty liver. Therefore, improving insulin sensitivity can be considered as an effective strategy for the prevention and treatment of these complex metabolic diseases. Cell-based models are extensively employed for the study of pathological mechanisms and drug screening, particularly in relation to insulin resistance in T2DM. Currently, numerous methods are available for the establishment of <i>in vitro</i> insulin resistance models, a comprehensive review of these models is required and can serve as an excellent introduction or understanding for researchers undertaking studies in this filed. This review examines and discusses the primary methods for establishing and evaluating insulin resistance cell models. Furthermore, it highlights key issues and suggestions on cell selection, establishment, evaluation and drug screening of insulin resistance, thereby providing valuable references for the future research efforts.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1469565"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for hormonal readiness and gut microbiota in obese polycystic ovary syndrome: an open-label, randomized controlled trial.","authors":"Tianyu Wu, Guixing Xu, Xiaojuan Hong, Huaying Fan, Jiuzhi Zeng, Yu Liu, Jinqun Hu, Fanrong Liang, Jie Yang, Jiao Chen","doi":"10.3389/fendo.2024.1509152","DOIUrl":"10.3389/fendo.2024.1509152","url":null,"abstract":"<p><strong>Objective: </strong>To explore whether acupuncture combined with clomiphene can reduce the luteinizing hormone-to follicle-stimulating hormone ratio and impact the gut microbiota in patients with obese polycystic ovary syndrome.</p><p><strong>Methods: </strong>This open-label, randomized, parallel-group controlled trial included 86 women aged 20-40 years with obese polycystic ovary syndrome and 19 healthy controls. Participants were randomly assigned to either an acupuncture combined with clomiphene group or a clomiphene-only group, with a healthy control group for comparison. The treatment lasted three menstrual cycles, with acupuncture administered three times weekly and clomiphene given daily from day five of menstruation for five consecutive days per cycle. The primary outcome was the change in the luteinizing hormone-to-follicle-stimulating hormone (LH/FSH) ratio. Secondary outcomes included levels of other sex hormones, glucose and lipid metabolism parameters, self-rating anxiety and depression scale scores, and gut microbiota composition.</p><p><strong>Results: </strong>Intention-to-treat analysis showed that the adjusted mean luteinizing hormone-to follicle-stimulating hormone ratio decrease was -0.8 (95% CI: -1.14 to -0.46) in the acupuncture combined with clomiphene group and -0.22 (95% CI: -0.47 to 0.01) in the clomiphene group. The adjusted between-group difference was 0.53 (95% CI: 0.24 to 0.82, <i>p</i> < 0.001). The levels of Agathobacter faecis increased, and those of <i>Erysipelatoclostridium spiroforme</i>, <i>Streptococcus lutetiensis</i>, and <i>Lactococcus lactis</i> decreased after acupuncture combined with clomiphene treatment (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Acupuncture combined with clomiphene may be safe and effective, reduce the luteinizing hormone-to follicle-stimulating hormone ratio, and improve insulin resistance in obese polycystic ovary syndrome, and these outcomes may be related to the gut microbiota.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1509152"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: The role of oxidized lipid species in insulin resistance and NASH in children.","authors":"Nicola Santoro, Ariel E Feldstein","doi":"10.3389/fendo.2024.1461564","DOIUrl":"https://doi.org/10.3389/fendo.2024.1461564","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fendo.2022.1019204.].</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1461564"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the risk of death and its associated risk factors in Chinese patients with young-onset type 2 diabetes.","authors":"Dan Wu, Yang Yu, Haoran Zheng, Ling Xiang, Xiaoqing Wang, Yong Zhang, Zhongming Sun, Dandan Miao, Jinyi Zhou, Enchun Pan, Wen Hu","doi":"10.3389/fendo.2024.1451364","DOIUrl":"10.3389/fendo.2024.1451364","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the association between the age at onset of diabetes and the risk of all-cause mortality in a population of individuals diagnosed with type 2 diabetes mellitus (T2DM) and to identify risk factors associated with all-cause mortality in young-onset T2DM (YOD) patients in China.</p><p><strong>Methods: </strong>This study utilized a cohort of 9759 patients who were diagnosed with T2DM and who were registered and enrolled in the National Basic Public Health Service Management Program in Qinghe District (now Qingjiangpu District) and Huai'an District, Huai'an City, Jiangsu Province, China. The patients were observed from November 2013 to July 2014, and all-cause mortality data were obtained by comprehensive matching with the Huai'an City Resident Mortality Database as of December 31, 2019. A Cox proportional hazards model was used to compute the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) for all-cause mortality risk during the follow-up period among patients with varying disease onset ages. Additionally, subgroup analyses were conducted based on sex, age, lifestyle factors, and baseline clinical parameters.</p><p><strong>Results: </strong>A total of 7572 patients with T2DM, including 2874 men and 4698 women aged 57.9 ± 8.0 years, were ultimately included in the study. 1) At baseline, a greater proportion of YOD patients were engaged in high-intensity activities, had a longer sleep duration, had a longer duration of T2DM, had a family history of T2DM, had microvascular complications (kidney disease, retinopathy, neuropathy, diabetic foot, etc.), and received glucose-lowering treatment. Moreover, patients in the YOD group also had significantly greater baseline HbA1c, FBG, and estimated glomerular filtration rate (eGFR) than did those in the onset at 41-60 years (MD) group and the onset at 61-75 years (SD) group. 2) During the six-year follow-up period, a total of 1057 deaths were documented. After adjusting for confounding factors and utilizing SD as the reference group, the HRs for deaths occurring in the YOD and MD groups were 1.383 (95% CI: 0.717-2.667) and 1.006 (95% CI: 0.763-1.326), respectively. Moreover, the risk of death in the YOD group remained highest in the sensitivity analysis that excluded patients with coronary heart disease at baseline, stroke patients, and patients who died within the first three years of follow-up. 3) Sleep duration was identified as an independent risk factor for mortality in the YOD group, with a notable increase in the risk of all-cause mortality when sleep duration exceeded 9 hours per day.</p><p><strong>Conclusion: </strong>The risk of all-cause mortality in YOD patients was 1.38 times greater than that in MD and SD patients, and the longer the sleep duration was, the greater the risk of death, especially when sleep duration exceeded 9 hours per day.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1451364"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}