Frontiers in Endocrinology最新文献

{"title":"J-Shaped relationship between the red cell distribution width to albumin ratio and erectile dysfunction: a cross-sectional study from NHANES 2001-2004.","authors":"Yang Xu, Shuofeng Li","doi":"10.3389/fendo.2025.1545272","DOIUrl":"https://doi.org/10.3389/fendo.2025.1545272","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a prevalent condition closely associated with systemic inflammation and metabolic disorders. The red cell distribution width to albumin ratio (RAR) is an emerging inflammatory marker; however, its relationship with ED remains poorly understood.</p><p><strong>Methods: </strong>This study conducted a cross-sectional analysis of data from 3,950 participants in the National Health and Nutrition Examination Survey (NHANES) 2001-2004 cycle to evaluate the association between RAR and ED risk. A Multivariable logistic regression model was employed to assess the relationship between RAR and ED, while a generalized additive model (GAM) and dose-response analysis were utilized to explore potential nonlinear associations. Subgroup analyses were performed to investigate interactions with demographic and lifestyle factors.</p><p><strong>Results: </strong>Among the study population, 1,157 individuals reported a history of ED. The prevalence of ED was significantly higher in individuals aged 50 years and older (86.78%) and was associated with increased rates of hypertension, diabetes mellitus, and cardiovascular disease (<i>P</i> < 0.001). A J-shaped relationship was identified between RAR and ED risk. Specifically, the risk of ED significantly increased below the RAR threshold of 3.42 (OR = 3.01, 95% CI: 2.08-4.36, <i>P</i> < 0.001), while the risk plateaued at higher RAR values. Subgroup analyses revealed significant interactions with ethnicity (P = 0.018) and moderate-intensity physical activity (<i>P</i> = 0.004). Non-Hispanic whites (OR = 2.85) and individuals engaging in moderate-intensity activity (OR = 3.83) exhibited a heightened risk of ED. No significant interactions were observed for other variables, including age and BMI.</p><p><strong>Conclusion: </strong>The results demonstrated that RAR was independently associated with ED risk, exhibiting a J-shaped relationship. There was a significant increase in risk below RAR = 3.42, with saturation occurring after exceeding this threshold.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1545272"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cemiplimab and diabetic ketoacidosis: a case report of a rare endocrinopathy associated with immune checkpoint inhibitors.","authors":"Anna Arecco, Cristian Petolicchio, Alessandro Pastorino, Enrica Teresa Tanda, Lara Vera, Mara Boschetti, Francesco Cocchiara, Davide Carlo Maggi, Diego Ferone, Federico Gatto","doi":"10.3389/fendo.2025.1550702","DOIUrl":"https://doi.org/10.3389/fendo.2025.1550702","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors (ICIs) have revolutionised the cancer treatment landscape in the last decades, improving the outcome of several tumours, such as cutaneous squamous cell carcinoma (cSCC). ICIs are antibodies blocking several immune checkpoint pathways, as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) with its ligand PD-L1. However, the activation of immune response can cause a broad range of side effects, called immune-related adverse events (irAEs). Endocrine irAEs are mainly represented by thyroid dysfunctions (thyrotoxicosis or hypothyroidism) and hypophysitis, while adrenal insufficiency and diabetes mellitus (DM) are less common. Diabetic ketoacidosis (DKA) is a potential life-threatening presentation of ICI-induced insulin-dependent DM (IDDM). This report presents a rare case of DKA and IDDM secondary to anti-PD-1 antibody cemiplimab therapy, and this is the third described in the literature to date.</p><p><strong>Case presentation: </strong>We describe the case of a 62-year-old female patient with metastatic perianal squamous cell carcinoma who developed DKA and IDDM after the fifth cycle of cemiplimab. Hyperglycemia (1187 mg/dL), metabolic acidosis (pH 7.27) with bicarbonate levels of 11.9 mmol/L, arterial partial pressure of carbon dioxide of 25.7 mmHg with increased anion gap (equal to 25), and hyperketonuria were present. Adequate glycaemic control was difficult to maintain, and intravenously therapy (insulin, sodium bicarbonate, potassium, and fluids) was required for a long time. Subcutaneous basal-bolus insulin treatment was started, but glycaemic control was scarce, also due to the concomitant administration of prednisone for immune-related hepatotoxicity, until the subject's death.</p><p><strong>Conclusion: </strong>This report underlines the importance of the awareness on endocrine irAEs with ICIs, particularly life-threatening DKA. A baseline assessment of glycemia and glycated hemoglobin is mandatory, and we recommend a close monitoring of glycemic trend over time during ICIs therapy. Patients and their caregivers should be informed and counselled to recognise DKA signs and symptoms.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1550702"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interpreting machine learning models to predict amputation risk in patients with diabetic foot ulcers: a multi-center study.","authors":"Haoran Tao, Lili You, Yuhan Huang, Yunxiang Chen, Li Yan, Dan Liu, Shan Xiao, Bichai Yuan, Meng Ren","doi":"10.3389/fendo.2025.1526098","DOIUrl":"https://doi.org/10.3389/fendo.2025.1526098","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) constitute a significant complication among individuals with diabetes and serve as a primary cause of nontraumatic lower-extremity amputation (LEA) within this population. We aimed to develop machine learning (ML) models to predict the risk of LEA in DFU patients and used SHapley additive explanations (SHAPs) to interpret the model.</p><p><strong>Methods: </strong>In this retrospective study, data from 1,035 patients with DFUs at Sun Yat-sen Memorial Hospital were utilized as the training cohort to develop the ML models. Data from 297 patients across multiple tertiary centers were used for external validation. We then used least absolute shrinkage and selection operator analysis to identify predictors of amputation. We developed five ML models [logistic regression (LR), support vector machine (SVM), random forest (RF), k-nearest neighbors (KNN) and extreme gradient boosting (XGBoost)] to predict LEA in DFU patients. The performance of these models was evaluated using several metrics, including the area under the receiver operating characteristic curve (AUC), decision curve analysis (DCA), precision, recall, accuracy, and F1 score. Finally, the SHAP method was used to ascertain the significance of the features and to interpret the model.</p><p><strong>Results: </strong>In the final cohort comprising 1332 individuals, 600 patients underwent amputation. Following hyperparameter optimization, the XGBoost model achieved the best amputation prediction performance with an accuracy of 0.94, a precision of 0.96, an F1 score of 0.94 and an AUC of 0.93 for the internal validation set on the basis of the 17 features. For the external validation set, the model attained an accuracy of 0.78, a precision of 0.93, an F1 score of 0.78, and an AUC of 0.83. Through SHAP analysis, we identified white blood cell counts, lymphocyte counts, and blood urea nitrogen levels as the model's main predictors.</p><p><strong>Conclusion: </strong>The XGBoost algorithm-based prediction model can be used to dynamically estimate the risk of LEA in DFU patients, making it a valuable tool for preventing the progression of DFUs to amputation.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1526098"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of animal models with chronic kidney disease-mineral and bone disorder based on clinical characteristics and pathogenesis.","authors":"Biyu Tan, Weili Tang, Yan Zeng, Jian Liu, Xiaomei Du, Hongwei Su, Xianlun Pang, Lishang Liao, Qiongdan Hu","doi":"10.3389/fendo.2025.1549562","DOIUrl":"https://doi.org/10.3389/fendo.2025.1549562","url":null,"abstract":"<p><p>Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic complication of chronic kidney disease (CKD), resulting in high morbidity and mortality. However, effective treatment strategies are lacking. The pathogenesis of CKD-MBD is unclear but involves feedback mechanisms between calcium, phosphorus, parathyroid hormone, vitamin D and other factors, in addition to FGF23, Klotho, Wnt inhibitors, and activin A. Construction of a perfect animal model of CKD-MBD with clinical characteristics is important for in-depth study of disease development, pathological changes, targeted drug screening, and management of patients. Currently, the modeling methods of CKD-MBD include surgery, feeding and radiation. Additionally, the method of CKD-MBD modeling by surgical combined feeding is worth promoting because of short time, simplicity, and low mortality. Therefore, this review based on the pathogenesis and clinical features of CKD-MBD, combined with the current status of animal models, outlines the advantages and disadvantages of modeling methods, and provides a reference for further CKD-MBD research.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1549562"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training on physical morphology, cardiopulmonary function, and metabolic indicators in older adults: a systematic review and meta-analysis.","authors":"Jie Men, Chengrui Zhao, Chenmin Xiang, Guoyu Zhu, Zhengyang Yu, Pengbo Wang, Simin Wu, Yuxi Zhang, Yishan Li, Liuliu Wang, Xueyan Gong, Xiang Yang, Shuangling Zou, Jia Ma, Chenglong Cui, Hao Li, Xuedi Ma, Wenjie Wu, Yaoming Wang","doi":"10.3389/fendo.2025.1526991","DOIUrl":"https://doi.org/10.3389/fendo.2025.1526991","url":null,"abstract":"<p><strong>Background: </strong>Despite the growing attention towards the efficacy of high-intensity interval training (HIIT) on older adult health, a consensus regarding the pleiotropic effects of HIIT in this population is yet to be reached. Previous studies have predominantly focused on specific outcomes or particular groups, lacking comprehensive analysis.</p><p><strong>Objective: </strong>We aimed to conduct a systematic evaluation of the impact of HIIT on body composition, cardiopulmonary function, and metabolic parameters in older adults.</p><p><strong>Methods: </strong>The databases searched included PubMed, Web of Science, Cochrane Library, Scopus, WanFang, and other relevant sources from the inception of the database until July 2023. Randomized controlled trials (RCTs) on the effects of HIIT on body shape, cardiopulmonary function, and metabolic parameters in the older adult were searched.</p><p><strong>Results: </strong>A total of 87 RCTs meeting the criteria were included, involving 4,213 older adult people. Meta-analysis results showed that HIIT significantly improved body fat percentage (BF%) [MD: -1.63%, <i>p</i> = 0.005], maximal oxygen uptake (VO_2max) [MD: 2.46 mL min^-1 kg^-1, <i>p</i> < 0.00001], maximal heart rate (HR_max) [MD: 2.83 beats min^-1, <i>p</i> = 0.02], and high-density lipoprotein (HDL) levels [MD: 0.04 mmol L^-1, <i>p</i> = 0.002]. However, for systolic blood pressure (SBP) [MD: 0.49 mmHg, p = 0.60], resting heart rate (HR_rest) [MD: -0.95 BPM ^-1, p = 0.24], triglycerides (TG) [tendency for MD: -0.02 mmol L^-1, p = 0.61], low-density lipoprotein (LDL) [MD: -0.04 mmol L^-1, p = 0.27] had no significant effect. Sensitivity analysis found that HIIT significantly improved waist circumference (WC) [MD: -1.89 cm, <i>p</i> = 0.17], diastolic blood pressure (DBP) [MD: -0.63 mmHg, <i>p</i> = 0.23], respiratory exchange rate (RER) [MD: 0.01, <i>p</i> = 0.20], total cholesterol (TC) [MD: 0.10 mmol L^-1, <i>p</i> = 0.14], and fasting plasma glucose (FPG) [MD:-0.20 mmol L^-1, <i>p</i> = 0.08], but the results lacked robustness. There was no significant improvement in DBP [MD: -0.63 mmHg, <i>p</i> = 0.23] and body mass index (BMI) [MD: -0.36 kg m^-2, <i>p</i> = 0.06].</p><p><strong>Conclusions: </strong>HIIT has shown certain potential and advantages in improving the physical health of the older adult, especially in cardiopulmonary function. However, more high-quality studies are needed to confirm the effects of HIIT on the physical health of the older adult in the future. It also provides a reference for the clinical practice and family health management of HIIT in the older adult and the development of HIIT guidelines.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/myprospero, identifier CRD42023460252.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1526991"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Can I afford to live today?\" The emotional toll of navigating the healthcare system with type 1 diabetes.","authors":"Shiraz Harel, James Lukasik, Annabelle Wilcox, Kasia J Lipska, Stuart A Weinzimer, Sakinah C Suttiratana, Laura M Nally","doi":"10.3389/fendo.2025.1555265","DOIUrl":"10.3389/fendo.2025.1555265","url":null,"abstract":"<p><strong>Objectives: </strong>People with diabetes (PWD) face significant barriers to accessing insulin and diabetes supplies, including high prices, leading some to turn to social media for material support. This study explores emotions among PWD who have relied on assistance from social media networks when navigating access to diabetes medications and supplies (DMS).</p><p><strong>Methods: </strong>We conducted a mixed methods study of individuals with type 1 diabetes (T1D) and their caregivers who have used social media to obtain DMS. Participants were recruited through social media based on self-reported use of social media to obtain diabetes support. Transcripts of semi-structured, telephone interviews were analyzed and categorized, and consensus discussions resolved discrepancies and refined definitions of themes.</p><p><strong>Results: </strong>Thirty individuals (mean age 31+/- 8 years, 29 female, 5 caregivers) were interviewed. The analysis revealed four categories of emotions: anxiety and stress, fear of health problems and financial consequences, frustration with the healthcare system, and feelings of powerlessness and vulnerability. Nearly all interviewees reported anxiety or stress due to the financial burden of managing diabetes and fear for their or their child's health and safety. Diabetic ketoacidosis, unnecessary bodily harm or sickness, or fear of dying due to running out of insulin worried participants. Most participants described the process of obtaining DMS to be more stressful than their daily diabetes management.</p><p><strong>Conclusions: </strong>PWD described strong negative emotions related to navigating the healthcare system and acquiring DMS. Policy changes are urgently needed to support to individuals with type 1 diabetes in order to enhance their quality of life, guarantee equitable access to care, and cultivate a more compassionate and inclusive healthcare system. The reported magnitude of stress is notable, especially given the attention typically focused on the stress of diabetes management.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1555265"},"PeriodicalIF":3.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative correlation between carotid or lower limb atherosclerosis and coronary heart disease: a retrospective observational study.","authors":"Zeyu Jiang, Shimiao Ruan, Kun Zhao, Shuhan Pan, Wenzhong Zhang","doi":"10.3389/fendo.2025.1570942","DOIUrl":"10.3389/fendo.2025.1570942","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis and intervention are key for the treatment of coronary heart disease (CHD). Ultrasound is used to assess risk stratification in patients with coronary artery disease. However, few studies quantify the relationship between carotid or lower limb atherosclerosis and coronary revascularization. The purpose of this study is to demonstrate that the semi-quantitative degree of atherosclerosis in the neck or lower extremity vessels can predict the need for coronary revascularization, thereby establishing a predictive model for coronary revascularization based on peripheral vascular disease.</p><p><strong>Methods: </strong>Patients who underwent coronary angiography and peripheral vascular ultrasound were randomly selected for semi-quantitative analysis of the degree of coronary artery and peripheral vascular stenosis. Data from 306 patients were collected.</p><p><strong>Results: </strong>The semiquantitative score, grade score and lower limb score from vascular ultrasound were positively correlated with the Gensini score of coronary artery lesions. The semi-quantitative score (score = 2) predicted the sensitivity and specificity for coronary revascularization at 83.74% and 61.72%, respectively. The graded score (score = 2) predicted the sensitivity and specificity for coronary revascularization at 77.24% and 72.13%, respectively. The lower extremity score (score = 3) predicted the sensitivity and specificity for coronary revascularization at 90.24% and 54.55%, respectively.</p><p><strong>Conclusions: </strong>Carotid semiquantitative scores, grade scores, and lower limb scores are predictive factors for the need for coronary revascularization and can serve as auxiliary examinations for the early diagnosis of coronary artery disease.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1570942"},"PeriodicalIF":3.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic survival outcomes of the tall-cell variant of papillary thyroid carcinoma patients after surgery.","authors":"Yuxiang Xue, Yizhen Zhuang, Shengxiang Chen","doi":"10.3389/fendo.2025.1517907","DOIUrl":"10.3389/fendo.2025.1517907","url":null,"abstract":"<p><strong>Background: </strong>Tall cell variant (TCV) represents the predominant aggressive subtype of papillary thyroid carcinoma (PTC). This study aimed to precisely characterize the evolving survival prognosis of these patients using extensive long-term follow-up data from a large cohort.</p><p><strong>Methods: </strong>Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, a cohort of 1004 eligible TCV patients diagnosed from 2004 to 2016 were included in this investigation. Conditional survival (CS) analysis was used to describe the evolving nature of survival changes for long-term TCV survivors. Following this, the cohort was divided into training and validation sets using a 7:3 ratio. The least absolute shrinkage and selection operator (LASSO) model was utilized to identify prognostically significant factors, which were subsequently integrated to construct a CS-nomogram model. Multiple evaluation methods, including calibration curves, the area under the receiver operating characteristic (ROC) curve, C-index, and decision curve analysis (DCA), were employed to assess the performance of this model.</p><p><strong>Results: </strong>Among included patients, the Kaplan-Meier method estimated a 10-year OS rate at diagnosis of 85%. In contrast, the CS analysis revealed annual increases, with survival rates improving from 85% at the initial diagnosis to 88%, 90%, 91%, 92%, 94%, 95%, 97%, 99%, and 99% for patients surviving 1 to 9 years after diagnosis, respectively. Through LASSO regression analysis, this study identified age, sex, N status, M status, AJCC stage, tumor size, surgery and radioactive iodine as key predictors for developing the CS-based nomogram. Calibration curves, ROC curves, C-index values, and DCA further determined nomogram model's effectiveness and reliability. Moreover, based on this CS-nomogram, we calculated risk scores for each patient and used risk scores to categorized patients into high- and low-risk groups in both training and validation cohorts. The Kaplan-Meier analysis with log-rank tests further validated the prognostic discriminative power of our risk stratification.</p><p><strong>Conclusions: </strong>The findings of our study comprehensively outlined the 10-year CS outcomes for TCV patients, revealing a steady increase in 10-year OS corresponding to each additional year of survival in TCV survivors. We also developed a CS-nomogram model, an individualized tool integrating time-varying covariates and patient-specific characteristics delivers real-time prognostic information tailored to each TCV patient.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1517907"},"PeriodicalIF":3.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Endocrine and metabolic consequences of childhood obesity, volume III.","authors":"Elpis Vlachopapadopoulou, Artur Mazur, Aneta Monika Gawlik, Grzegorz Telega, Malgorzata Wojcik, Dénes Molnár","doi":"10.3389/fendo.2025.1546470","DOIUrl":"10.3389/fendo.2025.1546470","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1546470"},"PeriodicalIF":3.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-shaped correlation between serum alpha-1-acid glycoprotein concentration and urinary albumin creatinine ratio in females: a cross-sectional survey.","authors":"Junjie Wang, Li Xiao, Yuxuan Zhang, Zhou Li","doi":"10.3389/fendo.2025.1438695","DOIUrl":"10.3389/fendo.2025.1438695","url":null,"abstract":"<p><strong>Background: </strong>Alpha-1-acid glycoprotein (AGP) is a vital acute phase reactant that increases when glomerular filtration is impaired, making it a potential biomarker of kidney disease. The urine albumin-to-creatinine ratio (UACR) is a sensitive indicator of proteinuria and is frequently used to screen for kidney disease in its early stage. The aim of this study was to explore their correlation in order to advance our understanding of the mechanisms underlying kidney damage.</p><p><strong>Methods: </strong>This study included 2579 female participants with serum AGP and UACR from the National Health and Nutrition Examination Survey (2015-2018). We divided all participants equally into three groups based on their serum AGP concentration. The univariate and multivariate regression models were for assessing the correlation between AGP and UACR. Subgroup analyses were then performed to explore the effect of each covariate on the correlation. Smoothing splines was utilized to explore their nonlinear correlation and identify thresholds within it.</p><p><strong>Results: </strong>After adjusting for multivariate models, AGP was significantly and positively associated with UACR (p<0.0001). The study identified a specific cohort of non-Hispanic Black individuals under 20 years of age, characterized by a BMI below 25 kg/m² and a waist circumference of 80 cm or more. Within this cohort, those with hypertension and sleep disorders but without hypercholesterolemia or diabetes exhibited significantly higher UACR (p < 0.001). Furthermore, we discovered an L-shaped correlation between serum AGP concentration and UACR. Specifically, when the serum AGP concentration was less than 140 mg/dL, the UACR plateaued.</p><p><strong>Conclusions: </strong>This study is the first to address the correlation between serum AGP and UACR and found an L-shaped correlation with a threshold of 140 mg/dl. This could be a target for intervention to reduce the risk of kidney disease.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1438695"},"PeriodicalIF":3.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}