Frontiers in Endocrinology最新文献

{"title":"Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies.","authors":"Yining Lu, Julien S Baker, Shanshan Ying, Yichen Lu","doi":"10.3389/fendo.2025.1481200","DOIUrl":"10.3389/fendo.2025.1481200","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this systematic review and meta-analysis was to investigate the effects of practical models of low-volume high-intensity interval training protocols (LV-HIIT) on glucose control and insulin resistance compared with moderate-intensity continuous training (MICT) protocols and no-exercise controls (CON).</p><p><strong>Methods: </strong>Four databases (PubMed, Web of Science, Scopus, and Cochrane Library) were searched for randomized controlled studies conducted using LV-HIIT interventions (HIIT/SIT protocols involving ≤ 15 min of intense training, within a session lasting ≤ 30 min; < 30 s all-out sprint for SIT additionally). The inclusion criteria required glucose and insulin resistance markers to be evaluated pre- and post-intervention among adults who were not trained athletes.</p><p><strong>Results: </strong>As a result, twenty studies were included, and meta-analyses were conducted using sixteen studies employing HIIT protocols. Compared with CON, LV-HIIT with reduced intensity and extended interval duration significantly improved fasting glucose (FPG) (mean difference (MD) in mg/dL=-16.63; 95% confidence interval (CI): -25.30 to -7.96; p<0.001) and HbA1c (MD=-0.70; 95% CI: -1.10 to -0.29; p<0.001). Greater improvements were found in participants who were overweight/obese or having type 2 diabetes (T2D). FPG decreased with every additional second of interval duration (β;=-0.10; 95% CI: -0.19 to -0.00; p=0.046). FPI (β;=-0.65; 95% CI: -1.27 to -0.02; p=0.042) and HOMA-IR (β;=-0.22; 95% CI: -0.36 to -0.09; p=0.001) decreased with every additional minute of interval duration per session. HOMA-IR also decreased with every additional minute of weekly interval duration (β;=-0.06; 95%CI: -0.08 to -0.04; p<0.001). Compared with MICT, LV-HIIT was more effective in improving insulin sensitivity (SMD=-0.40; 95%CI: -0.70 to -0.09; p=0.01), but there were no differences in FPG, FPI, HbA1c or HOMA-IR (p>0.05). The effect of LV-HIIT on FPI was larger compared with MICT among individuals who lost weight.</p><p><strong>Conclusion: </strong>Conclusively, a practical model of LV-HIIT with reduced intensity and extended interval was effective in improving glucose control and its effects were similar to MICT. Greater improvements were found in individuals with overweight/obesity or T2D in protocols with longer intervals or accumulated interval duration per session/week. More large-scale, randomized controlled studies with similar intervention protocols in a wide range of population are warranted to confirm these important results.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42024516594.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1481200"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The endocrine role of the musculoskeletal system.","authors":"Siyi Zhu, Giuseppina Storlino, Sandeep Kumar","doi":"10.3389/fendo.2025.1552950","DOIUrl":"10.3389/fendo.2025.1552950","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1552950"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study.","authors":"Zhuyuan Zheng, Shaojie Yang, Wanlin Dai, Yang Sun, Jingnan Wang, Xiaolin Zhang, Yiming Zheng, Jing Kong","doi":"10.3389/fendo.2024.1436827","DOIUrl":"10.3389/fendo.2024.1436827","url":null,"abstract":"<p><strong>Background: </strong>This study explored the causal connection among the plasma lipidome, nonalcoholic fatty liver disease (NAFLD), and potential metabolome mediators through Mendelian randomization (MR).</p><p><strong>Methods: </strong>We obtained summary statistics for 179 plasma lipidome traits (<i>N</i> = 7,174), 1,400 plasma metabolome traits (<i>N</i> = 8,299), and one NAFLD trait from publicly available genome-wide association studies. A two-sample MR analysis was conducted to infer causality. Additionally, multiple sensitivity analyses were conducted to assess the heterogeneity, horizontal pleiotropy, and robustness of the MR findings. MetaboAnalyst 6.0 was used for the pathway analysis of the identified lipids and metabolites. Furthermore, we used mediation analysis to assess whether the effect of plasma lipidome on NAFLD was mediated by plasma metabolome.</p><p><strong>Results: </strong>The MR analysis predicted a genetically determined causal relationship between plasma lipidomes and NAFLD. No compelling proof was found that genetically predicted NAFLD influenced the risk of the five plasma lipidomes mentioned earlier. Based on established causal relationships between lipids and metabolites, we identified that eight metabolic pathways are closely associated with NAFLD. Our mediation analysis revealed six mediation relationships, indicating the causal pathway from plasma lipids to NAFLD mediated by five specific metabolites. No potential pleiotropy was found in the sensitivity analysis.</p><p><strong>Conclusions: </strong>In summary, our study identified causal relationships between plasma lipidomes, plasma metabolomes, and NAFLD. Certainly, the impact of plasma lipidomes on NAFLD is not limited to plasma metabolomes, indicating a need to further investigate into other possible mediators. These identified factors may become new biomarkers of the NAFLD contributing to its prevention, diagnosis, and treatment.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1436827"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005-2018.","authors":"Jianming Yin, Chuanjie Zheng, Xiaoqian Lin, Chaoqiang Huang, Zhanhui Hu, Shuyuan Lin, Yiqian Qu","doi":"10.3389/fendo.2024.1499417","DOIUrl":"10.3389/fendo.2024.1499417","url":null,"abstract":"<p><p>Previous studies have indicated an association between UHR and diabetes risk, but evidence from large-scale and diverse populations remains limited. This study aims to verify UHR's independent role in diabetes risk prediction in a large sample population and assess its applicability across different populations. We drew upon data from 30,813 participants collected during the 2005-2018 NHANES cycle. The association between UHR and the risk of diabetes was explored using multivariate logistic regression models, with key predictive factors identified through LASSO regression. Model effectiveness was evaluated through receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration metrics. Additionally, restricted cubic spline (RCS) and threshold effect assessments were applied to examine the nonlinear association between UHR and diabetes risk. The results showed that UHR levels were notably elevated in individuals with diabetes when compared to those without diabetes (<i>p</i> < 0.001). The occurrence of diabetes showed a marked increase across ascending UHR quartiles (6.63%, 10.88%, 14.15%, 18.02%; <i>p</i> < 0.001). Results from multivariate logistic regression indicated that elevated UHR was strongly linked to a heightened risk of diabetes; participants in the highest UHR quartile were found to have nearly four times the risk compared to those in the lowest quartile (OR = 4.063, 95% CI: 3.536-4.669, <i>p</i> < 0.001). Subgroup analyses demonstrated that the predictive effect of UHR was more pronounced in females. Key variables selected via LASSO regression improved the model's performance. Restricted cubic spline (RCS) analysis indicated an inflection point at UHR = 10; beyond this point, diabetes risk accelerated, and when UHR exceeded 18, the risk increased significantly (OR > 1). ROC curve analysis showed the baseline model (M1) had an area under the curve (AUC) of 0.797, while the multivariable model (M4) after LASSO selection had an AUC of 0.789. Decision curve analysis and calibration curves validated the model's predictive ability and consistency. This study indicates that UHR may be an independent predictor of diabetes risk, showing a positive correlation with diabetes and a more pronounced predictive effect in females.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1499417"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Improving diagnosis and management of genetic lipodystrophy.","authors":"Milena Teles, Rinki Murphy","doi":"10.3389/fendo.2024.1543126","DOIUrl":"https://doi.org/10.3389/fendo.2024.1543126","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1543126"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.","authors":"Hui Zhang, Minghui Chen, Lijie Sun, Wenwen Zhu, Tong Niu, Huzaifa Fareeduddin Mohammmed Farooqui, Hongxiao Wang, Bing Song, Jumei Wang, Haoqiang Zhang","doi":"10.3389/fendo.2025.1501323","DOIUrl":"10.3389/fendo.2025.1501323","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to investigate the role of activated partial thrombin time (APTT) as a potential mediator in the relationship between suboptimal glycemic control and diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A total of 183 T2DM patients were enrolled in this study. Comprehensive clinical data, including coagulation parameters and nerve conduction velocity, were collected and compared between patients with and without DPN. Subsequent correlation and regression analyses were conducted to explore the associations among APTT, HbA1c levels, and nerve conduction velocities. Moreover, mediation analyses were performed to evaluate the total, direct, and indirect effects of HbA1c on specific nerve conduction velocities, with APTT serving as a mediator.</p><p><strong>Results: </strong>In comparison to 101 patients without DPN, 82 patients with DPN exhibited significantly elevated levels of HbA1c and decreased levels of APTT. Notably, levels of APTT and HbA1c were correlated with conduction velocities of Tibial nerve motor fibers, as well as sensory fibers of the Ulnar nerve, Median nerve, and Sural nerve. Furthermore, both elevated HbA1c and decreased APTT were identified as risk factors for DPN in T2DM individuals. Mediation analysis showed that APTT mediated the indirect effect of HbA1c on the conduction velocities of sensory fibers in both the ulnar nerve and sural nerve (95% CI: -0.3448, -0.0135; -0.3523, -0.0180). APTT mediated the relationship between HbA1c and the conduction velocities of sensory fibers in the ulnar nerve or sural nerve by 34.66% or 22.03%, respectively.</p><p><strong>Conclusions: </strong>In patients with T2DM, uncontrolled HbA1c and shorter APTT emerges as risk factors for DPN. Additionally, the effect of increased HbA1c upon DPN, especially for influenced conduction velocities of sensory fibers in both the ulnar nerve and sural nerve may partly medicated by decreased APTT.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1501323"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Chinese visceral adiposity index and serum uric acid levels in type 2 diabetes mellitus patients.","authors":"Swailla Amina Araújo Intchasso Adotey, Qian Zhang, Mengxue Chen, Yang Jiao, Yin Zhang, Claudette Butoyi, Dong Wang, Ling Yang, Guoyue Yuan, Jue Jia","doi":"10.3389/fendo.2025.1479662","DOIUrl":"10.3389/fendo.2025.1479662","url":null,"abstract":"<p><strong>Purpose: </strong>The Chinese Visceral Adiposity Index (CVAI), a measure of visceral adiposity dysfunction, is used to assess visceral fat (VFA) malfunction. This research was performed to evaluate the relationship between CVAI and serum uric acid levels in type 2 diabetes mellitus (T2DM) patients.</p><p><strong>Methods: </strong>A total of 2268 patients with T2DM were enrolled in this study. We collected the general clinical information of patients, measured the basic anthropometric indicators, tested glycolipid metabolism and biochemical indicators, and measured the visceral and subcutaneous fat area with bioelectrical impedance technology. According to the quartiles of the CVAI, the T2DM patients were classified into four groups: group A (CVAI ≤ 94.43), group B (94.43<CVAI ≤ 118.75), group C (118.75<CVAI ≤ 143.95), and group D (CVAI≥143.95), each group has 567 participants. Participants were divided into hyperuricemia (HUA) and non-HUA groups, and the clinical data between the two groups was compared.</p><p><strong>Results: </strong>Among quartiles of CVAI, as CVAI increased, the proportion of patients with HUA gradually increased. The correlation analysis showed that the majority of basal measures, glycolipid metabolism and biochemical indicators were positively correlated with CVAI. By comparison, the level of CVAI in the HUA group was significantly higher than non-HUA group. Meanwhile, through using the ROC curve, our study observed the more predictive value of CVAI than other obesity indicators for T2DM with HUA.</p><p><strong>Conclusion: </strong>CVAI is a simple but effective indicator, which is significantly correlated with HUA in T2DM and can reflect the incidence of HUA in T2DM patients. As CVAI increased, the risk of HUA in T2DM patients increased. Therefore, we should pay more attention to the application of CVAI in T2DM.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1479662"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in presentation of pheochromocytoma and paraganglioma.","authors":"Nora Azin Ali, Jan Calissendorff, Henrik Falhammar","doi":"10.3389/fendo.2025.1463945","DOIUrl":"10.3389/fendo.2025.1463945","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to investigate sex differences in presentation of pheochromocytomas and paragangliomas (PPGLs).</p><p><strong>Methods: </strong>This is a retrospective cohort study including 183 patients with confirmed PPGL (females n=100, pheochromocytoma n=156) between year 2005 and 2023, attending Department of Endocrinology, Karolinska University Hospital, Stockholm. The collected data included the mode of presentation, symptoms, biochemical, genetic and histopathological test results.</p><p><strong>Results: </strong>The mean age at surgery/diagnosis was 54.9 ± 17.0 years. Sweating was more common in females compared to males (44% vs 23%, p=0.003), and also takotsubo syndrome (10% vs 0% p=0.002). Males, on the other hand, were more likely to experience pallor (16% vs 4%, p=0.009), and were more often diagnosed due to investigations of a suspected PPGL (31% vs 18%, p=0.039) although no difference was found in the classic triad (sweating, palpitations and headache). Left-sided pheochromocytoma was more common among males than females (48% vs 29%, p=0.009). No differences between sexes were found in biochemical, genetical or histopathological results, or presence of metastasis at diagnosis.</p><p><strong>Conclusions: </strong>The reported symptoms by patients with PPGL were generally similar between the sexes, except for pallor and sweating. Takotsubo syndrome was more common among females. More males with PPGL were found based on suspicion than females. Further research into sex differences in various aspects of PPGL should be pursued.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1463945"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5,10-methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for premature coronary artery disease in patients with type 2 diabetes mellitus.","authors":"Nisreen O Mohammed, Ibtisam A Ali, Bahaelddin K Elamin, Bakri Osman Saeed","doi":"10.3389/fendo.2024.1502497","DOIUrl":"10.3389/fendo.2024.1502497","url":null,"abstract":"<p><strong>Background: </strong>Africa, like the rest of the world, is experiencing an increasing prevalence of diabetes mellitus. Diabetes increases the risk for coronary artery disease (CAD) by fourfold compared to people without diabetes. C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) and hyperhomocysteinemia were reported by many studies as risk factors for CAD among patients with type 2 diabetes mellitus (T2DM). Early detection of modifiable risk factors for CAD is an important aspect of management of diabetes. This is the only study in Sudan which investigates the association between MTHFR genotypes and plasma homocysteine levels, and their role in premature CAD (PCAD) among patients with T2DM.</p><p><strong>Methods: </strong>This study is a comparative study. We enrolled 226 Sudanese patients with T2DM, age range 25-60 years, recruited from Alshaab and Omdurman teaching hospitals in Khartoum State. 113 patients had CAD confirmed by angiography and electrocardiography (ECG) and 113 had no evidence of CAD. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), using Hinf1 restriction enzyme, were used to determine MTHFR genotypes. Plasma homocysteine levels were determined by enzymatic assay on the Hitachi Cobas Integra^® 400 plus. Data was analyzed using statistical package for Social Sciences (SPSS) 23, using Mann-Whtney U test, general linear model, Chi-square test and logistic regression analysis.</p><p><strong>Results: </strong>The frequencies of TT, CT, and CC genotypes were 16,40 and 44% among T2DM patients with PCAD. In T2DM patients without PCAD, the frequencies of TT, CT, and CC genotypes were 00,19 and 83%. The T allele showed strong association with PCAD among T2DM patients, <i>p <</i>0.001, odds ratio (OR) 6.2, 95% CI (3.4-11.6). Patients with PCAD showed higher plasma homocysteine levels than patients without PCAD (13.5 µmol/L versus 10 µmol/L, <i>p</i> < 0.001). The T allele had significant effect on homocysteine level, (<i>p <</i>0.001). Plasma homocysteine levels were higher in individuals with TT genotype than those with CT or CC genotypes in patients with PCAD (16.2 + 5.3, 14.3 + 5.7 and 12.9 + 5.02 µmol/L, <i>p</i>=0.017). Homocysteine levels showed a significant association with CAD, <i>p</i><0.001, OR 3.2, 95% CI (1.9-5.5).</p><p><strong>Conclusions: </strong>Our study suggests that C677T polymorphism of MTHFR gene and hyperhomocysteinemia are risk factors for PCAD in Sudanese population with T2DM.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1502497"},"PeriodicalIF":3.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirtuins in kidney homeostasis and disease: where are we now?","authors":"Zhongyu Fan, Xuejiao Wei, Xiaoyu Zhu, Yujun Du","doi":"10.3389/fendo.2024.1524674","DOIUrl":"10.3389/fendo.2024.1524674","url":null,"abstract":"<p><p>Sirtuins, identified as (NAD⁺)- dependent class III histone deacetylases, engage in a spectrum of biological functions, encompassing DNA damage repair, oxidative stress, immune modulation, mitochondrial homeostasis, apoptosis and autophagy. Sirtuins play an apoptosis role in regulating cellular operations and overall organism health. Mounting data indicate that dysregulated sirtuin expression is linked to the onset of renal diseases. Effective modulation of sirtuins expression and activity has been shown to improve renal function and attenuate the advancement of kidney diseases. In this review, we present a comprehensive overview of the biological impacts of sirtuins and their molecular targets in regulating renal diseases. Additionally, we detail advancements in elucidating sirtuin roles in the pathophysiology of both chronic and acute renal disorders. We review compounds that modulate sirtuin activity through activation or inhibition, potentially improving outcomes in renal disease. In summary, strategic manipulation of sirtuin activity represents a prospective therapeutic approach for renal diseases.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"15 ","pages":"1524674"},"PeriodicalIF":3.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}