Frontiers in Endocrinology最新文献

{"title":"Cardiometabolic risk assessment by anthropometric and biochemical indices in mexican population.","authors":"Luz Quirino-Vela, Miguel Mayoral-Chavez, Yobana Pérez-Cervera, Osiris Ildefonso-García, Elizabeth Cruz-Altamirano, Monserrat Ruiz-García, Juan Alpuche","doi":"10.3389/fendo.2025.1588469","DOIUrl":"10.3389/fendo.2025.1588469","url":null,"abstract":"<p><strong>Background: </strong>Cardiometabolic risk (CMR) factors, including obesity, hypertension, hyperglycemia, and dyslipidemia, are major contributors to global morbidity and mortality. Although gold-standard diagnostic methods for obesity and insulin resistance exist, they are costly and inaccessible in resource-limited settings. Conventional anthropometric measures underestimate parameters that enhance risk prediction and fail explaining the complex relationship between adipose tissue distribution and metabolic dysfunction. This study evaluated and compared the diagnostic accuracy of 15 conventional and non-conventional anthropometric and biochemical indices for identifying CMR factors in Mexican adults. We hypothesized that non-conventional indices would demonstrate superior diagnostic performance compared with traditional measures.</p><p><strong>Methods: </strong>We analyzed data from 1,876 participants aged 20-80 years from the 2022 National Health and Nutrition Survey (ENSANUT). Anthropometric indices, including body mass index (BMI), waist-to-height ratio (WHtR), body roundness index (BRI), deep abdominal adipose tissue index (DAAT), and weight-adjusted waist index (WWI), were calculated alongside biochemical indices such as HOMA-IR, triglyceride-glucose index (TG), and combined indices like TG*BMI and TG*WC. Receiver operating characteristic (ROC) curve analysis evaluates diagnostic performance, with sex-stratified analyses conducted to determine optimal cut-off values.</p><p><strong>Results: </strong>Non-conventional indices demonstrated superior diagnostic performance across all outcomes. For obesity detection, TG*BMI achieved the highest area under the curve (AUC=0.972), followed by WHtR and BRI (AUC=0.934). For CMR assessment, BRI showed perfect discrimination (AUC=1.000), whereas TG*WC (AUC=0.976) and LAP (AUC=0.963) demonstrated exceptional performance. Sex-based analyses revealed that optimal cut-off values varied, with most indices maintaining a consistent discriminatory capacity across sexes.</p><p><strong>Conclusions: </strong>Non-conventional anthropometric indices, particularly those incorporating metabolic and anthropometric parameters, outperform traditional BMI-based assessments for CMR stratification in Mexican adults. These accessible, cost-effective tools offer superior diagnostic accuracy and enhance early identification of high-risk individuals in resource-limited healthcare settings. Future studies are required to validate these findings and establish population-specific reference values.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1588469"},"PeriodicalIF":4.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional imaging techniques plus ¹⁸F-Fluorocholine PET/CT: a comparative study of diagnostic accuracy in localizing parathyroid adenomas in primary hyperparathyroidism.","authors":"Wei-Yih Chiu, Kuen-Yuan Chen, Chia-Tung Shun, Ming-Hsun Wu, Keh-Sung Tsai, Ching-Hung Chiu, Wei-Shiung Yang, Ruoh-Fang Yen","doi":"10.3389/fendo.2025.1595461","DOIUrl":"10.3389/fendo.2025.1595461","url":null,"abstract":"<p><strong>Background: </strong>Currently ¹⁸F-Fluorocholine (FCH)-PET/CT is a choice beyond widely used techniques like ultrasound (US) and technetium-99m sestamibi (MIBI) for primary hyperparathyroidism (pHPT). It remains uncertain how FCH-PET/CT collaborates with those two traditional modalities. This study aims to prospectively evaluate the effectiveness of individual, complementary, and combined utilization of FCH-PET/CT for preoperative localization.</p><p><strong>Methods: </strong>All participants underwent US, MIBI, and FCH-PET/CT examinations, and eligible patients underwent parathyroid surgery based on surgical indications and patient preferences. McNemar's test compared diagnostic performance between imaging techniques and Spearman's rank correlation correlated FCH-PET/CT parameters with lesion volume, laboratory, and histological features.</p><p><strong>Results: </strong>63 out of 83 recruited patients underwent parathyroidectomy. Histologically confirmed parathyroid lesions were found in 69 glands among 63 patients. FCH-PET/CT exhibited higher sensitivity than US, MIBI, and US/MIBI combination (87.0% vs. 49.3%, <i>P <</i>0.001; vs. 49.3%, <i>P <</i>0.001; vs. 66.7%, <i>P</i>=0.006). As a second-line modality after US, MIBI, and US/MIBI combination, FCH-PET/CT achieved sensitivities of 88.6%, 77.1%, and 80.9% in detecting US-negative lesions, MIBI-negative lesions, and lesions with negative or conflicting US/MIBI results, respectively. Among various imaging combinations, the combined use of US and FCH-PET/CT showed significantly higher sensitivity than FCH-PET/CT alone (94.2% vs. 87.0%, <i>P</i>=0.025) and similar sensitivity with higher specificity than the combination of all three modalities (sensitivity: 94.2% vs. 95.7%, <i>P</i>=0.317; specificity: 98.9% vs. 95.1%, <i>P</i>=0.008).</p><p><strong>Conclusions: </strong>FCH-PET/CT is effective as a first-line or complementary technique, irrespective of prior US, MIBI or US/MIBI combination. US combined with FCH-PET/CT appears to be the most effective localization strategy among the modalities evaluated in this study. Our findings support an ultrasound-first approach for localizing primary hyperparathyroidism, with FCH-PET/CT referral in uncertain cases to enhance success rates.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1595461"},"PeriodicalIF":4.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-disordered breathing and metabolic syndrome across gender, age, and sleep subtypes in East Asians.","authors":"Tong Feng, Qiong Ou, Guangliang Shan, Yaoda Hu, Huijing He","doi":"10.3389/fendo.2025.1519638","DOIUrl":"10.3389/fendo.2025.1519638","url":null,"abstract":"<p><strong>Background: </strong>Previous research has classified sleep-disordered breathing (SDB) into various symptom phenotypes. The cardiovascular risks associated with SDB differ by gender, age, and subtype, with uncertainty about the mediating role of metabolic syndrome in these risks. This study has three primary objectives: (1) to analyze the correlation between SDB and MetS risk across gender-age groups and symptom subtypes, (2) to identify the nocturnal hypoxia parameter most indicative of this relationship, and (3) to evaluate the link between sleep parameters (insomnia, daytime sleepiness, snoring, and sleep duration) and MetS. Combining these parameters into a sleep quality score may improve predictions of health outcomes.</p><p><strong>Methods: </strong>Participants underwent type IV sleep monitoring and completed structured questionnaires. MetS was defined according to the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 Edition). We conducted a latent class analysis to categorize patients based on SDB symptoms and characteristics.</p><p><strong>Results: </strong>The severity of SDB was independently associated with an increased risk of metabolic syndrome, particularly in males under 60 and females aged 60 and above. A total of 1,483 SDB patients were categorized into four distinct clusters: Cluster 1 included the pure insomnia group with fewer daytime symptoms; Cluster 2 consisted of the minimally symptomatic group; Cluster 3 comprised the insomnia group with multiple daytime symptoms; and Cluster 4 encompassed the group with upper airway symptoms and sleepiness. Among the SDB subtypes, there was no significant difference in the prevalence of metabolic syndrome. However, the pure insomnia group had the highest prevalence of hypertension.</p><p><strong>Conclusion: </strong>These findings highlight the importance of considering gender, age differences, and sleep symptom subtypes when evaluating and managing metabolic syndrome. Tailored strategies, early identification, and consideration of different subtypes are necessary to optimize treatment.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1519638"},"PeriodicalIF":4.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of the prognostic implications of glycemic variability on all-cause mortality in critically ill patients with mitral valve disease.","authors":"Jie Peng, Xingzhan Zhang, Yunjing Mai, Hongzhi Chen, Dakai Liang, Shaobo Li, Huanhuan Wu, Chao Li, YuanShuo Ge, Guangdong Wang, Ling Zhao","doi":"10.3389/fendo.2025.1620762","DOIUrl":"10.3389/fendo.2025.1620762","url":null,"abstract":"<p><strong>Background: </strong>Mitral valve disease is associated with higher cardiovascular morbidity and mortality. Glycemic variability (GV), reflecting blood glucose fluctuations, acts as an independent indicator for results in critically ill patients. However, it's effect on patients in the ICU with mitral valve disease is unclear.</p><p><strong>Methods: </strong>All blood glucose measurements of patients with mitral valve disease were extracted from MIMIC-IV database. GV was assessed using the coefficient of variation of glucose levels. Cox hazard regression models and restrictive cubic spline (RCS) were applied to examine the link between GV and outcomes. A threshold effect analysis was also conducted to explore potential inflection points. Subgroup analyses were performed to assess consistency across demographics and clinical subgroups.</p><p><strong>Results: </strong>The study of 3,378 adults with mitral valve disease found that higher GV was significantly associated with increased 28-day and 90-day mortality, as shown by Cox regression analysis. Subgroup analyses confirmed these findings.</p><p><strong>Conclusions: </strong>For ICU patients with mitral valve disease, elevated GV was an independent predictor of short-term mortality. GV was recommended for consideration in risk stratification and glucose management strategies, particularly in non-diabetic critically ill populations. Monitoring and targeting GV were proposed to new avenues for improving clinical outcomes in this high-risk group.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1620762"},"PeriodicalIF":4.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population.","authors":"Yu Gong, Guojuan Wang, Qianqian Zhang, Xu Jiang, Zhangxiang Zhu, Ying Li","doi":"10.3389/fendo.2025.1616907","DOIUrl":"10.3389/fendo.2025.1616907","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the correlation between central thyroid hormone sensitivity and Hypertriglyceridemia (HTG) in euthyroid population.</p><p><strong>Methods: </strong>A total of 833 individuals who underwent physical examinations were randomly selected. Biochemical parameters including thyroid hormones (THs), liver and kidney functions, blood glucose, and blood lipids were measured. Central TH sensitivity was evaluated using the thyroid feedback quantile-based index (TFQI), thyroid-stimulating hormone index (TSHI) and thyrotropin thyroxine resistance index (TT4RI). ​​ We analyzed the relationship between central TH sensitivity and triglyceride (TG) level using smooth curve fitting and threshold effect analysis and trend tests in multiple regression equations.​.</p><p><strong>Results: </strong>TSHI (β=0.158, <i>P</i>=0.0443) was positively correlated with TG, while TT4RI (β=0.018, <i>P</i>=0.0112, inflection point: 25.809) and TFQI (β=0.798, <i>P</i>=0.0066, inflection point: -0.194) were both positively correlated with TG before the inflection points. Subgroup analyses revealed these relationships were particularly pronounced in females (TT4RI β=0.026, <i>P</i>=0.0205, inflection point: 22.487; TFQI β=0.780, <i>P</i>=0.0133, inflection point: -0.142), males (TFQI β=1.954, <i>P</i>=0.0100, inflection point: -0.395), individuals with age <65 years (TT4RI β=0.019, <i>P</i>=0.0119, inflection point: 25.809; TFQI β=0.878, <i>P</i>=0.0060, inflection point: -0.206), and individuals with BMI<28kg/m² (TT4RI β=0.026, <i>P</i>=0.0090, inflection point: 21.515; TFQI β=0.735, <i>P</i>=0.0132, inflection point: -0.173), all showing positive correlations before the point correlations. Tests for trend in multiple regression equations showed that with the increased quartiles of TT4RI (OR=1.321, <i>P</i>=0.00118) and TSHI (OR=1.253, <i>P</i>=0.00784), the risk of HTG increased correspondingly. For per SD increase in TT4RI, the odds of HTG increased by 36.5% (OR=1.365, <i>P</i>=0.00703). For per SD increase in TSHI, the odds of HTG increased by 19.1% (OR=1.191, <i>P</i>=0.06648).</p><p><strong>Conclusion: </strong>Impaired central thyroid hormone sensitivity is associated with increased triglyceride in euthyroid population, this association is more pronounced in individuals with aged<65 years and BMI<28kg/m². Impaired central thyroid hormone sensitivity may be an independent risk factor for hypertriglyceridemia.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1616907"},"PeriodicalIF":4.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue in acromegaly patients: a scoping review.","authors":"Wei Wang, Xiaoxu Han, QingHua Huang","doi":"10.3389/fendo.2025.1601661","DOIUrl":"10.3389/fendo.2025.1601661","url":null,"abstract":"<p><strong>Purpose: </strong>This scoping review systematically examines current evidence on fatigue in acromegaly patients, with a particular focus on incidence, risk factors, hazards, assessment tools and therapeutic interventions, to inform evidence-based interventions aimed at improving rehabilitation outcomes.</p><p><strong>Methods: </strong>A scoping review was conducted following the PRISMA-ScR guidelines. We systematically searched five international databases (PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library) and three Chinese databases (CNKI [China National Knowledge Infrastructure], WanFang, and Sinomed) from their inception through June 21, 2025. The inclusion criteria included original studies investigating fatigue manifestations in patients with acromegaly, including epidemiological studies, psychometric validation reports, and intervention trials. The exclusion criterion was articles focused exclusively on pharmacological or surgical interventions without fatigue assessment. Two independent researchers performed literature screening, data extraction, and quality appraisal via standardized protocols.</p><p><strong>Results: </strong>A total of 20 studies were included (all English-language publications). The prevalence of fatigue in acromegaly patients is high, ranging from 49% to 92%. Objective fatigue assessment tools primarily involve electromyography (EMG) and isokinetic dynamometry of the knee joint. Subjective fatigue was evaluated with patient self-reports. Factors that influence fatigue in these patients include demographic characteristics, sociological factors, sleep disturbances, comorbidities, and disease-specific factors. Interventions included aerobic exercise, rehabilitation therapist-guided home rehabilitation programs, and cognitive behavioral therapy.</p><p><strong>Conclusion: </strong>This scoping review underscores the need for future large-scale longitudinal studies on fatigue in acromegaly. Priority areas include identifying predictive markers, understanding pathophysiological mechanisms, evaluating targeted interventions, and developing standardized assessment tools to improve early recognition and management.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1601661"},"PeriodicalIF":4.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of embryo transfer strategies on children health outcomes: a retrospective national cohort study in Taiwan.","authors":"Chih-Ting Chang, Shih-Feng Weng, Hui-Yu Chuang, Chia-Yi Hsu, Eing-Mei Tsai","doi":"10.3389/fendo.2025.1630293","DOIUrl":"10.3389/fendo.2025.1630293","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of different assisted reproductive technology (ART) embryo transfer strategies on neonatal and early childhood health outcomes, focusing on fresh versus frozen transfers and cleavage versus blastocyst stages.</p><p><strong>Design: </strong>Retrospective cohort study analyzing data from Taiwan's national assisted reproduction database (2013-2017).</p><p><strong>Methods: </strong>The study included 10,803 ART-conceived singleton births and 894,615 naturally conceived singletons. ART groups were categorized by embryo transfer type: fresh cleavage stage, fresh blastocyst, frozen cleavage stage, and frozen blastocyst. Maternal, paternal, and perinatal outcomes were adjusted using inverse probability of treatment weighting (IPTW). Outcomes included major and minor diseases in offspring, such as ADHD, developmental delays, atopic dermatitis, and respiratory diseases.</p><p><strong>Results: </strong>ART-conceived children had higher rates of major and minor health conditions compared to naturally conceived peers, particularly preterm birth, ADHD, and developmental delay. No significant differences were observed in major disease incidence between frozen and fresh transfers or cleavage and blastocyst stages. The elevated risks in ART-conceived children may reflect the influence of underlying parental infertility rather than ART procedures alone.</p><p><strong>Conclusion: </strong>While ART is linked to increased risks of certain adverse health outcomes, the choice between embryo transfer strategies has minimal impact on neonatal or early childhood health. These findings underscore the need to optimize ART protocols and perinatal care while addressing the role of parental infertility in shaping offspring health.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1630293"},"PeriodicalIF":4.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for glucocorticoid induced osteoporosis in young adults.","authors":"Helena Florez, Josep Lluis Carrasco, Martina Barberá, José Hernández-Rodríguez, Africa Muxi, Anastasia Mocritcaia, Sergio Prieto-González, Maria C Cid, Ana Monegal, Núria Guañabens, Pilar Peris","doi":"10.3389/fendo.2025.1528962","DOIUrl":"10.3389/fendo.2025.1528962","url":null,"abstract":"<p><strong>Introduction: </strong>Glucocorticoid-induced osteoporosis (GIOP) is one of the most frequent causes of secondary osteoporosis, especially in young subjects. However, current research and guidelines have scarcely addressed the therapeutic approach and risk factors for GIOP in adults less than 50 years of age. The aim of the study was to analyze if factors related to the development of glucocorticoid-induced osteoporosis (GIOP) and fragility fractures (FF) differ according to age.</p><p><strong>Methods: </strong>127 patients on chronic glucocorticoid (GC) treatment were analyzed, including GC doses and duration, disease activity, FF, anthropometric data, bone metabolism parameters (including sex steroids), bone mineral density, trabecular bone score, and radiologic vertebral fractures; defining GIOP as densitometric osteoporosis and/or FF. Young subjects (<50 years old) were compared with those ≥50 years for risk factors of GIOP and FF.</p><p><strong>Results: </strong>GIOP prevalence was similar in both age groups: <50 (n=36) 44.4% <i>vs.</i> 46.1% ≥50 years (n=91). Five subjects <50 (13.9%) and 30 ≥50 years (33%) presented FF (p=0.046). Having a higher body mass index (BMI), disease activity was a differential risk factor for FF in young subjects, whereas hypogonadism was a risk factor independent of age.</p><p><strong>Conclusions: </strong>More than 40% of young subjects on chronic GC therapy had GIOP. A higher BMI and disease activity and particularly, hypogonadism seem to be factors related to FF development in these subjects. Evaluation of these risk factors can improve the identification of young subjects at increased risk of fracture.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1528962"},"PeriodicalIF":4.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shanling Jiangzhi Tea treats hyperuricemia by inhibition of COMT/MAOA signaling pathway and p53/SERPINE1/NLRP3 signaling pathway.","authors":"Hao-Nan Chen, He-Zhen Wu, Yan-Fang Yang","doi":"10.3389/fendo.2025.1623111","DOIUrl":"10.3389/fendo.2025.1623111","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the therapeutic efficacy of Shanling Jiangzhi Tea (SLJZ) on hyperuricemia (HUA) mice and to investigate its mechanism.</p><p><strong>Methods: </strong>A HUA mouse model was established using a combination of uric acid (UA)and potassium oxonate. Following SLJZ intervention, changes in body weight were monitored. Renal lesions and renal fibrosis were assessed via H&E staining and Masson trichrome staining. Serum levels of UA, creatinine (Cr), blood urea nitrogen (BUN), and xanthine oxidase (XOD) were measured to evaluate the UA-lowering effects of SLJZ. Ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was employed to identify the bioactive components of SLJZ that entered the bloodstream. Network pharmacology, molecular docking, and transcriptomics analyses were conducted to elucidate the key targets and signaling pathways involved in SLJZ's therapeutic effects on HUA. Protein expression levels were further validated using immunohistochemistry.</p><p><strong>Results: </strong>SLJZ significantly reduces the levels of UA, Cr, BUN, and XOD in the blood of HUA mice, alleviates inflammatory cell infiltration, attenuates renal interstitial fibrosis, and demonstrates therapeutic potential for hyperuricemia. RNA-seq analysis reveals that SLJZ reverses 280 HUA-induced differentially expressed genes (DEGs) in the kidneys. Based on the findings from network pharmacology and molecular docking analyses, SERPINE1, p53, NLRP3, COMT, and MAOA are identified as potential key proteins involved in SLJZ's treatment of HUA. Kit-based assays indicate that SLJZ increases dopamine (DA) levels in the kidneys of mice while reducing the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). Immunohistochemical results confirm that SERPINE1, p53, NLRP3, COMT, and MAOA are significantly upregulated in the kidneys of HUA model mice, but their expression is normalized following SLJZ intervention.</p><p><strong>Conclusion: </strong>SLJZ exhibits a significant anti-HUA effect by inhibiting the COMT/MAOA signaling pathway and the p53/SERPINE1/NLRP3 signaling pathway. Through these mechanisms, SLJZ is involved in the DA metabolic process, modulates the inflammatory response mediated by the SERPINE1 fibrinolytic system, alleviates renal tubulointerstitial fibrosis, and mitigates oxidative stress, thereby exerting therapeutic effects on HUA.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1623111"},"PeriodicalIF":4.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of prediction models for special subtype of primary aldosteronism: patients with negative adrenal CT imaging.","authors":"Hong Zhao, Pan Hu, Min Mao, Xin Li, Ling Wang, Jing Chang","doi":"10.3389/fendo.2025.1563748","DOIUrl":"10.3389/fendo.2025.1563748","url":null,"abstract":"<p><strong>Objective: </strong>Current subtype diagnosis of primary aldosteronism relies on adrenal venous sampling and imaging, each with inherent limitations. Lesional adrenal glands with negative CT Imaging is a distinct subtype of primary aldosteronism that has been less frequently studied. The aim of this study was to develop and validate a machine learning and AI model for distinguishing adrenals with transversely negative lesions from normal adrenals Primary Aldosteronism.</p><p><strong>Materials and methods: </strong>We conducted a single-center retrospective study, assessing transverse adrenal scans of 170 PA patients. A specialized iterative method was employed for radiomic feature selection. Subsequently, six conventional machine learning methodologies were utilized to construct the radiomics models. This original data was subsequently applied in the construction of a radiomic model, which was combined with clinical data for the final model construction.</p><p><strong>Results: </strong>107 radiomic features were extracted from the adrenal scans and 10 features were selected for ML and AI modeling. In the clinical data, values for serum potassium, aldosterone excretion, uric acid, and IVSd were utilized in the model construction. The integration of clinical data further enhanced the model's performance, with an AUC reaching 0.868 in the derived cohort, and an AUC of 0.853 in the temporal validation cohort.</p><p><strong>Conclusion: </strong>The study indicates that clinical-radiomic scores can independently serve as diagnostic biomarkers for the specialized PA subtype categorization. We give the proposal for the precise categorization concept in establishing a clinical-radiomic model for PA subtype diagnosis. The model demonstrates substantial potential for both clinical and translational research.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1563748"},"PeriodicalIF":4.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}