{"title":"Fatigue in acromegaly patients: a scoping review.","authors":"Wei Wang, Xiaoxu Han, QingHua Huang","doi":"10.3389/fendo.2025.1601661","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This scoping review systematically examines current evidence on fatigue in acromegaly patients, with a particular focus on incidence, risk factors, hazards, assessment tools and therapeutic interventions, to inform evidence-based interventions aimed at improving rehabilitation outcomes.</p><p><strong>Methods: </strong>A scoping review was conducted following the PRISMA-ScR guidelines. We systematically searched five international databases (PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library) and three Chinese databases (CNKI [China National Knowledge Infrastructure], WanFang, and Sinomed) from their inception through June 21, 2025. The inclusion criteria included original studies investigating fatigue manifestations in patients with acromegaly, including epidemiological studies, psychometric validation reports, and intervention trials. The exclusion criterion was articles focused exclusively on pharmacological or surgical interventions without fatigue assessment. Two independent researchers performed literature screening, data extraction, and quality appraisal via standardized protocols.</p><p><strong>Results: </strong>A total of 20 studies were included (all English-language publications). The prevalence of fatigue in acromegaly patients is high, ranging from 49% to 92%. Objective fatigue assessment tools primarily involve electromyography (EMG) and isokinetic dynamometry of the knee joint. Subjective fatigue was evaluated with patient self-reports. Factors that influence fatigue in these patients include demographic characteristics, sociological factors, sleep disturbances, comorbidities, and disease-specific factors. Interventions included aerobic exercise, rehabilitation therapist-guided home rehabilitation programs, and cognitive behavioral therapy.</p><p><strong>Conclusion: </strong>This scoping review underscores the need for future large-scale longitudinal studies on fatigue in acromegaly. Priority areas include identifying predictive markers, understanding pathophysiological mechanisms, evaluating targeted interventions, and developing standardized assessment tools to improve early recognition and management.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1601661"},"PeriodicalIF":4.6000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301152/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fendo.2025.1601661","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: This scoping review systematically examines current evidence on fatigue in acromegaly patients, with a particular focus on incidence, risk factors, hazards, assessment tools and therapeutic interventions, to inform evidence-based interventions aimed at improving rehabilitation outcomes.
Methods: A scoping review was conducted following the PRISMA-ScR guidelines. We systematically searched five international databases (PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library) and three Chinese databases (CNKI [China National Knowledge Infrastructure], WanFang, and Sinomed) from their inception through June 21, 2025. The inclusion criteria included original studies investigating fatigue manifestations in patients with acromegaly, including epidemiological studies, psychometric validation reports, and intervention trials. The exclusion criterion was articles focused exclusively on pharmacological or surgical interventions without fatigue assessment. Two independent researchers performed literature screening, data extraction, and quality appraisal via standardized protocols.
Results: A total of 20 studies were included (all English-language publications). The prevalence of fatigue in acromegaly patients is high, ranging from 49% to 92%. Objective fatigue assessment tools primarily involve electromyography (EMG) and isokinetic dynamometry of the knee joint. Subjective fatigue was evaluated with patient self-reports. Factors that influence fatigue in these patients include demographic characteristics, sociological factors, sleep disturbances, comorbidities, and disease-specific factors. Interventions included aerobic exercise, rehabilitation therapist-guided home rehabilitation programs, and cognitive behavioral therapy.
Conclusion: This scoping review underscores the need for future large-scale longitudinal studies on fatigue in acromegaly. Priority areas include identifying predictive markers, understanding pathophysiological mechanisms, evaluating targeted interventions, and developing standardized assessment tools to improve early recognition and management.
目的：本综述系统地检查了肢端肥大症患者疲劳的现有证据，特别关注发病率、危险因素、危害、评估工具和治疗干预，为旨在改善康复结果的循证干预提供信息。方法：根据PRISMA-ScR指南进行范围审查。我们系统地检索了5个国际数据库（PubMed、Embase、CINAHL、Web of Science和Cochrane Library）和3个中国数据库（CNKI[中国国家知识基础设施]、万方和中国医学信息网），从它们成立到2025年6月21日。纳入标准包括调查肢端肥大症患者疲劳表现的原始研究，包括流行病学研究、心理测量验证报告和干预试验。排除标准是只关注药物或手术干预而不进行疲劳评估的文章。两名独立研究人员通过标准化方案进行文献筛选、数据提取和质量评估。结果：共纳入20篇研究（均为英文出版物）。肢端肥大症患者的疲劳患病率很高，从49%到92%不等。客观疲劳评估工具主要包括肌电图（EMG）和膝关节等速动力学测量。主观疲劳用患者自我报告进行评估。影响这些患者疲劳的因素包括人口统计学特征、社会因素、睡眠障碍、合并症和疾病特异性因素。干预措施包括有氧运动、康复治疗师指导的家庭康复计划和认知行为疗法。结论：这一范围综述强调了未来对肢端肥大症患者疲劳进行大规模纵向研究的必要性。优先领域包括确定预测标记物，了解病理生理机制，评估有针对性的干预措施，以及开发标准化评估工具以改善早期识别和管理。
期刊介绍：
Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series.
In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology.
Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.
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