Frontiers in Endocrinology最新文献

{"title":"Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular disease mortality in patients with type 2 diabetes mellitus and diabetic kidney disease.","authors":"Zhiyu Li, Hongyang Xu","doi":"10.3389/fendo.2025.1509752","DOIUrl":"https://doi.org/10.3389/fendo.2025.1509752","url":null,"abstract":"<p><strong>Purpose: </strong>Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) represents an essential lipid index and is closely related to the occurrence and development of diabetes and cardiovascular diseases (CVDs). Therefore, this study is intended to further investigate the association between the NHHR index and the mortality rate of CVDs in patients with type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD).</p><p><strong>Methods: </strong>The research sample was selected from the NHANES (National Health and Nutrition Examination Survey) database, and 5136 individuals were categorized based on quartiles of the NHHR index. Restricted cubic plots and COX regression models were utilized to examine the thresholds and patterns of the NHHR index in relation to the risk of CVDs mortality among T2DM patients as well as those with DKD. Subgroup analyses and p-values were used to evaluate interactions between different variables.</p><p><strong>Results: </strong>The NHHR index shows a nonlinear association with cardiovascular mortality in two patient groups, following an L-shaped pattern. In individuals with T2DM, a lower NHHR index (<1.68) correlates with an increased risk of death, demonstrating a 72.8% reduction in mortality risk for each unit increase in NHHR below this threshold. Similarly, among patients with DKD, a lower NHHR index (<1.82) is associated with heightened cardiovascular mortality risk, indicating a 48.2% reduction in death risk for each unit increase in NHHR beneath the specified threshold. In patients diagnosed with T2DM, the third quartile of the NHHR index was significantly linked to reduced mortality risk; the association remained consistent even when additional variables were considered [Hazard Ratio (HR), 0.82; 95% Confidence Interval (CI) (0.69-0.97); P=0.019]. Among patients with DKD, cardiovascular mortality was notably higher in the third and fourth quartiles of the NHHR index [Quartile3 HR, 1.57; 95% CI (1.10-2.24), P=0.013; Quartile4 HR, 2.04; 95% CI (1.28-3.26), P=0.003].</p><p><strong>Conclusions: </strong>The NHHR is below 1.68, and an increase in the NHHR index is associated with a reduced risk of CVD mortality in patients with T2DM. Similarly, when the NHHR falls below 1.82, an elevation in the NHHR index correlates with a decreased risk of CVD mortality in patients with DKD.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1509752"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography provides a \"one-stop-shop\" targeted analysis for coronary artery calcification and osteoporosis: a review.","authors":"Jing Luo, Qian Wang, Wenhong Liu, Huazhi Liao, Weipeng Qing, Minyi Zhang, Deqiu Tang, Guanghua Luo, Heng Zhao","doi":"10.3389/fendo.2025.1356831","DOIUrl":"https://doi.org/10.3389/fendo.2025.1356831","url":null,"abstract":"<p><p>The global trend towards longer lifespans has led to an aging population and a rise in the prevalence of diseases that predominantly affect elderly people. Coronary artery calcification (CAC) and osteoporosis (OP) are common in elderly populations. CT scans provide a reliable method to assess and monitor the progression of these diseases. In this review, the relationship between OP and CAC in terms of pathophysiological mechanism, comorbidity risk factors and clinical manifestations is reviewed, with a focus on the advancements in CT imaging, clinical applications and the possibility for \"one-stop-shop\" for examination.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1356831"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Xiangshao granules on clinical symptoms and serum hormone levels of menopausal syndrome: a systematic review and meta-analysis of randomized controlled trials.","authors":"Xing Tang, Chengcheng Wang, Yang Liu, Yisha Xu, Shoujin Dong, Min Dai, Chunmei Li, Yan Zhai, Shoujen Lan, Yeayin Yen, Chao Wang, Congcong Yu","doi":"10.3389/fendo.2025.1546200","DOIUrl":"https://doi.org/10.3389/fendo.2025.1546200","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the efficacy and safety of Xiangshao granules in improving clinical symptoms and regulating serum hormone levels in patients with menopausal syndrome (MPS).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study was developed according to the PRISMA 2020 guidelines. Eight databases including PubMed, Web of Science, The Cochrane Library, Embase, CNKI, CBM, Wanfang Database, and VIP database were searched for randomized controlled trials (RCTs) of Xiangshao Granules in the treatment of MPS. The search time was from the listing of Xiangshao Granules (2005) to September 1, 2024. Xiangshao granule was used in experimental group. The control group was treated with placebo, other Chinese patent medicine, or conventional western medicine. The treatment period should be at least 4 weeks. RevMan5.4 was used for bias risk assessment and meta-analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 13 randomized controlled trials with 1637 participants were included. The meta-analysis showed that there was statistical significance between Xiangshao granules and control group in improving clinical symptoms (P&lt;0.05). Xiangshao granules could improve the total response rate (OR= 2.78, 95%CI[1.65, 4,68], P&lt;0.05) and reduce Kupperman score (MD=-1.23, 95%CI[-2.10,-0.36], P&lt;0.05). In addition, Xiangshao granules also decreased HAMD score (MD= -2.80, 95%CI[-3.54, -2.07], P&lt;0.05) and HAMA score (MD=-2.52, 95%CI[-3.00,-2.04], P&lt;0.05). In terms of serum hormone levels, there was no significant difference in serum FSH levels between Xiangshao granule group and control group(SMD=-0.81, 95%CI[-2.03, 0.41], P= 0.19). However, the regulating effect of Xiangshao granules on serum LH and E2 levels was statistically significant compared with the control group (P&lt;0.05). The results of subgroup analysis showed that Xiangshao granules were better than other Chinese patent medicines in reducing serum LH levels (SMD=-1.20, 95%C[-1.66,-0.73]I, P&lt;0.05). Xiangshao granules were superior to other Chinese patent medicines or placebo in increasing serum E2 levels (SMD=5.28, 95%CI[4.90, 5.66], P&lt;0.05) (SMD=2.00, 95%CI[1.10, 2.90], P&lt;0.05). Furthermore, the combined use of western medicine and Xiangshao granules was better than HRT or SSRIs alone in reducing serum LH level and increasing serum E2 level (P&lt;0.05). In terms of safety, there was no significant difference in the incidence of adverse reactions among all groups (OR= 1.28, 95%CI[0.80, 2.05], P = 0.31).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Xiangshao Granules can effectively relieve the clinical symptoms of MPS patients, improve the scores of anxiety and depression and regulate the level of serum estrogen, with good safety, and is an ideal treatment plan. In the future, multi-center and large sample randomized controlled trials can be conducted for more key clinical indicators to comprehensively analyze the clinical efficacy and applicability of Xiangshao granules in the treatment of MPS.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Syste","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1546200"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound radiomics and genomics improve the diagnosis of cytologically indeterminate thyroid nodules.","authors":"Lu Chen, Mingbo Zhang, Yukun Luo","doi":"10.3389/fendo.2025.1529948","DOIUrl":"https://doi.org/10.3389/fendo.2025.1529948","url":null,"abstract":"<p><strong>Background: </strong>Increasing numbers of cytologically indeterminate thyroid nodules (ITNs) present challenges for preoperative diagnosis, often leading to unnecessary diagnostic surgical procedures for nodules that prove benign. Research in ultrasound radiomics and genomic testing leverages high-throughput data and image or sequence algorithms to establish assisted models or testing panels for ITN diagnosis. Many radiomics models now demonstrate diagnostic accuracy above 80% and sensitivity over 90%, surpassing the performance of less experienced radiologists and, in some cases, matching the accuracy of experienced radiologists. Molecular testing panels have helped clinicians achieve accurate diagnoses of ITNs, preventing unnecessary diagnostic surgical procedures in 42%-61% of patients with benign nodules.</p><p><strong>Objective: </strong>In this review, we examined studies on ultrasound radiomics and genomic molecular testing for cytological ITNs conducted over the past 5 years, aiming to provide insights for researchers focused on improving ITN diagnosis.</p><p><strong>Conclusion: </strong>Radiomics models and molecular testing have enhanced diagnostic accuracy before surgery and reduced unnecessary diagnostic surgical procedures for ITN patients.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1529948"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a risk prediction model for 30-day readmission in elderly type 2 diabetes patients complicated with heart failure: a multicenter, retrospective study.","authors":"Yuxin He, Yuan Yuan, Qingzhu Tan, Xiao Zhang, Yunyu Liu, Minglun Xiao","doi":"10.3389/fendo.2025.1534516","DOIUrl":"10.3389/fendo.2025.1534516","url":null,"abstract":"<p><strong>Background: </strong>Elderly type 2 diabetes mellitus (T2DM) patients complicated with heart failure (HF) exhibit a high rate of 30-day readmission. Predictive models have been suggested as tools for identifying high-risk patients. Thus, we aimed to develop and validate a predictive model using multicenter electronic medical records (EMRs) data to estimate the risk of 30-day readmission in elderly T2DM patients complicated with HF.</p><p><strong>Methods: </strong>EMRs data of elderly T2DM patients complicated with HF from five tertiary hospitals, spanning 2012 to 2023, were utilized to develop and validate the 30-day readmission model. The model were evaluated using holdout data with the area under the receiver operating characteristic curve (AUROC), calibration curves, decision curve analysis (DCA), and clinical impact curves (CIC).</p><p><strong>Results: </strong>A total of 1899 patients were included, with 955, 409, and 535 in the derivation, internal validation, and external validation cohorts, respectively. Pulmonary infections (odds ratio [OR]: 3.816, 95% confidence interval [CI]: 2.377-6.128, <i>P</i> < 0.001), anti-hypertensive drug use (OR: 5.536, 95% CI: 1.658-18.486, <i>P</i> = 0.005), and neutrophil percentage-to-albumin ratio (NPAR) (OR: 1.144, 95% CI: 1.093-1.197, <i>P</i> < 0.001) were independent predictors of 30-day readmission risk. AUROC in the derivation, internal validation, and external validation cohorts were 0.782 (95% CI: 0.737-0.826), 0.746 (95% CI: 0.654-0.838), and 0.753 (95% CI: 0.684-0.813), respectively. The calibration curve, DCA results, and CIC results indicated that the model also possessed good predictive power. Additionally, an operation interface on a web page (https://cqykdxtjt.shinyapps.io/readmission/) was created for clinical practitioners to apply.</p><p><strong>Conclusion: </strong>A 30-day readmission risk prediction model was developed and externally validated. This model facilitates the targeting of interventions for elderly T2DM patients complicated with HF who are at high risk of an early readmission.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1534516"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Novel insights into the pathophysiology of diabetes-related complications: implications for improved therapeutic strategies, volume II.","authors":"Jian Ma, Yinghao Guo, Chunjie Jiang, Xuebin Fu","doi":"10.3389/fendo.2025.1570628","DOIUrl":"10.3389/fendo.2025.1570628","url":null,"abstract":"","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1570628"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-driven ultrasound radiomics for assessing axillary lymph node burden in breast cancer.","authors":"Si-Rui Wang, Feng Tian, Tong Zhu, Chun-Li Cao, Jin-Li Wang, Wen-Xiao Li, Jun Li, Ji-Xue Hou","doi":"10.3389/fendo.2025.1548888","DOIUrl":"10.3389/fendo.2025.1548888","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the value of combining intratumoral and peritumoral radiomics features from ultrasound imaging with clinical characteristics to assess axillary lymph node burden in breast cancer patients.</p><p><strong>Methods: </strong>A total of 131 breast cancer patients with axillary lymph node metastasis (ALNM) were enrolled between June 2019 and September 2024. Patients were divided into low (n=79) and high (n=52) axillary lymph node burden (ALNB) groups. They were further split into training (n=92) and validation (n=39) cohorts. Intratumoral and peritumoral features were analyzed using the maximum relevance minimum redundancy (MRMR) and least absolute shrinkage and selection operator (LASSO) methods. Six machine learning models were evaluated, and a combined clinical-radiomics model was built.</p><p><strong>Results: </strong>The combined logistic regression model exhibited superior diagnostic performance for high axillary lymph node burden, with areas under the ROC curve (AUC) of 0.857 in the training cohort and 0.820 in the validation cohort, outperforming individual models. The model balanced sensitivity and specificity well at a 52% cutoff value. A nomogram provided a practical risk assessment tool for clinicians.</p><p><strong>Conclusion: </strong>The combined clinical-radiomics model showed excellent predictive ability and may aid in optimizing management and treatment decisions for breast cancer patients.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1548888"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in thyroid function after thermal ablation of thyroid nodules.","authors":"Song Li, Ming-An Yu, Zhen-Long Zhao, Ying Wei, Li-Li Peng, Yan Li","doi":"10.3389/fendo.2025.1557725","DOIUrl":"10.3389/fendo.2025.1557725","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate changes in thyroid function post-thermal ablation (TA) of thyroid nodules and to identify risk factors associated with post-ablation thyroid function abnormalities.</p><p><strong>Materials and methods: </strong>A retrospective analysis of 2,264 cases treated with TA between June 2015 and July 2024 was conducted, including 1,169 benign thyroid nodules (BTNs) and 1,095 papillary thyroid carcinoma (PTC) cases. Thyrotropin (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured before treatment and at 1, 3, 6, 9, and 12 months post-ablation.</p><p><strong>Result: </strong>FT3 levels remained significantly reduced at 12 months post-ablation (3.04 ± 0.42 vs. 3.15 ± 0.36 pg/mL; <i>p</i> < 0.001). In contrast, FT4 levels showed a persistent increase at 12 months (1.36 ± 0.69 vs. 1.27 ± 0.15 ng/dL; <i>p</i> < 0.001). Although TSH levels decreased slightly over time, they remained elevated at 12 months compared to baseline (1.80 ± 1.17 vs. 1.73 ± 0.84 μIU/mL; <i>p</i> = 0.029). At the end of the follow-up period, the incidence of thyroid function abnormalities was 5.07% (18/355), with only one patient requiring Thiamazole for antithyroid therapy. The cumulative incidence of thyroid function abnormalities was notably higher in the PTC group compared to the BTN group (17.80% vs. 10.94%; <i>p</i> < 0.001). Pre-ablation TSH levels (OR= 2.06; 95% CI, 1.77-2.39; <i>p</i> < 0.001), Hashimoto's thyroiditis (OR = 2.66; 95% CI, 1.88-3.77; <i>p</i> < 0.001), and multiple nodules were positively correlated with the occurrence of thyroid function abnormalities. The cutoff value of TSH was 2.015 μIU/mL with a sensitivity of 0.527 and a specificity of 0.246 (AUC = 0.625).</p><p><strong>Conclusion: </strong>Thermal ablation had a minimal impact on thyroid function. Pre-ablation TSH levels, Hashimoto's thyroiditis, and multiple nodules were risk factors for post-ablation thyroid function abnormalities.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1557725"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum inflammatory markers in early-pregnancy with the risk for gestational diabetes mellitus: a prospective cohort in Shenzhen, China.","authors":"Yijin Wang, Qinqin Ren, Hui Yuan, Yang Wang, Yao Liu, Yuanhuan Wei, Ruifang Sun, Hongguang Yang, Ping Tian, Jianjun Yang, Guifang Deng","doi":"10.3389/fendo.2025.1486848","DOIUrl":"10.3389/fendo.2025.1486848","url":null,"abstract":"<p><strong>Introduction: </strong>The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) have recently been reported as novel inflammatory markers of diabetes. However, the associations of SII and SIRI with the risk of gestational diabetes mellitus (GDM) are unclear. In our study, we explored the association between the SII and SIRI in early pregnancy and the risk of GDM in pregnant women.</p><p><strong>Methods: </strong>A prospective cohort of 1,505 pregnant women were recruited at 6-13 weeks of gestation in 2019 and 2020 in Shenzhen, China. SII and SIRI were determined by calculating the composite inflammation indicators from routine blood test results at 6-13 weeks of gestation, and an oral glucose tolerance test was conducted at 24-28 weeks of gestation to diagnose GDM. Logistic regression was used to analyse the correlations between the incidence of GDM and SII and SIRI. Using a restriction cubic spline with baseline SII and SIRI as continuous variables, the dose-response associations between the incidence of GDM and SII and SIRI were explored.</p><p><strong>Results: </strong>Following Ln-transformation of the SII and SIRI, multivariate models showed that Ln (SII) (odds ratio [OR] = 1.759; 95% confidence interval [CI]: 1.272-2.432) and Ln (SIRI) (OR = 1.556; 95% CI: 1.187-2.042) were positively associated with the risk of GDM in a dose-dependent manner. The OR for the highest quartile of SII compared with the lowest quartile for the risk of GDM was 2.080 (95% CI: 1.447-2.990), and the OR for the highest quartile of SIRI compared with the lowest quartile was 1.694 (95% CI: 1.170-2.452). The restricted cubic spline model confirmed a linear association between Ln (SII) and Ln (SIRI) with the risk of GDM (p-nonlinear > 0.05).</p><p><strong>Discussion: </strong>Higher SII and SIRI in early pregnancy are associated with an increased risk of GDM. As novel, valuable, and convenient indicators of inflammation, SII and SIRI could be used to a potential predictor for GDM in early pregnancy.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1486848"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of targeted CXCR4 ¹⁸F-AlF-NOTA-pentixafor PET/CT for subtyping primary aldosteronism.","authors":"Yushi Peng, Fangansheng Chen, Rui Yao, Junping Lan, Yinuo Fu, Kaifeng Ye, Zhiqiang Wang, Qianxiu Zhao, Xiaowei Ji, Kang Xia, Guoqing Zhu, Kewen Zheng, Xuemei Gu, Kun Tang","doi":"10.3389/fendo.2025.1533295","DOIUrl":"10.3389/fendo.2025.1533295","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to investigate the diagnostic value of ¹⁸F-AlF-NOTA-Pentixafor PET/CT in subtyping primary aldosteronism (PA).</p><p><strong>Methods: </strong>This study enrolled 88 patients with PA or nonfunctional adenoma (NFA) for ¹⁸F-Pentixafor PET/CT scan. Of these, 20 patients underwent adrenal venous sampling (AVS), and 65 underwent adrenalectomy and postoperative follow-up.</p><p><strong>Results: </strong>In 88 patients, 76 were diagnosed with unilateral PA (UPA), 4 were diagnosed with bilateral PA (BPA), and 8 were diagnosed with NFA, resulting in a total of 95 lesions. To identify UPA, visual analysis received a specificity of 94.12% and a sensitivity of 89.74%. The optimal cutoff values for SUV_max at 5.45, the lesion-to-normal adrenal ratio (LAR) at 1.43, and lesion-to-liver ratio (LLR) all yielded a specificity of 100% and a sensitivity of 79.49%, 83.33%, and 80.77%, respectively. In 15 adrenal lesions with similar uptake to contralateral and adjacent normal adrenal tissue (defined as warm lesions), 7 were confirmed as UPA, 4 were confirmed as BPA, and 4 were confirmed as NFA. Furthermore, among the 20 patients who underwent AVS, the concordance rate of AVS and PET/CT visual analysis for PA subtyping was 65.00%.</p><p><strong>Conclusions: </strong>The CXCR4-targeted ¹⁸F-AlF-NOTA-pentixafor PET/CT is a valuable noninvasive tool for diagnosing UPA, demonstrating high sensitivity and specificity. More attention should be paid to warm adrenal lesions for their high diagnostic ambiguity probability.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1533295"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}