Frontiers in Endocrinology最新文献

{"title":"The impact of different ovarian stimulation protocols on the expression levels of GDF-9 and BMP-15 in cumulus cells of follicles.","authors":"Lili Cheng, Jie Zhang, Dongxiu Li, Pengyu Xu, Shan Liu, Ruijuan Guo, Xue Wang, Li Zhang","doi":"10.3389/fendo.2025.1572388","DOIUrl":"10.3389/fendo.2025.1572388","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the expression levels of the oocyte-secreted factors growth differentiation factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15) in cumulus cells (CCs) under different controlled ovarian stimulation (COS) protocols and their association with oocyte maturity and embryo developmental potential.</p><p><strong>Methods: </strong>This study included 76 patients requiring intracytoplasmic sperm injection (ICSI) due to severe oligoasthenoteratozoospermia or previous ICSI treatment, resulting in the collection of 749 CC samples. Patients were divided into four groups based on COS protocols: short-acting luteal phase (14 patients, 168 CCs), long-acting follicular phase (21 patients, 189 CCs), micro-stimulation (12 patients, 86 CCs) and antagonist (29 patients, 306 CCs). The mRNA was extracted from cumulus granulosa cells, and the relative levels of GDF-9 and BMP-15 were measured using real-time quantitative PCR (Q-PCR). The expression levels of GDF-9 and BMP-15 were compared across different ovarian stimulation protocols, while oocyte maturation, fertilization, cleavage, and blastocyst formation were assessed. The expression levels of GDF-9 and BMP-15 were compared across protocols, and oocyte maturation, fertilization, cleavage and blastocyst formation were assessed.</p><p><strong>Results: </strong>GDF-9 and BMP-15 levels were substantially higher in MII oocytes than in MI and GV oocytes and were also elevated in the normal fertilization group, high-quality cleavage embryos and high-quality blastocysts. Growth differentiation factor-9 expression was higher in the short-acting luteal phase protocol than in the antagonist protocol, whereas BMP-15 expression was higher in both the short-acting luteal phase and long-acting follicular phase protocols compared with the micro-stimulation and antagonist groups.</p><p><strong>Conclusion: </strong>GDF-9 and BMP-15 are reliable indicators of oocyte developmental potential. The long-acting follicular phase and short-acting luteal phase protocols enhance oocyte maturity and embryo development, whereas the micro-stimulation and antagonist protocols appear less favorable.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1572388"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral adiposity loss is associated with improvement in cardiometabolic markers: findings from a dietary intervention study.","authors":"Shazana Rifham Abdullah, Ahmad Kamil Nur Zati Iwani, Liyana Ahmad Zamri, Ruziana Mona Wan Mohd Zin, Norhashimah Abu Seman, Nur Azlin Zainal Abidin, Siti Sarah Hamzah, Nur Hayati Azizul, Azahadi Omar, Zamtira Seman, Abqariyah Yahya, Mohd Fairulnizal Md Noh","doi":"10.3389/fendo.2025.1576599","DOIUrl":"10.3389/fendo.2025.1576599","url":null,"abstract":"<p><strong>Background: </strong>Visceral adiposity is closely linked with cardiometabolic disorders, but evidence on the extent of visceral fat loss required for significant improvement in cardiometabolic markers remains limited. This study aims to investigate the association between visceral fat area (VFA) reductions and improvements in cardiometabolic markers following a 3-month dietary intervention.</p><p><strong>Methods: </strong>A total of 175 adults with overweight and obesity were involved in this non-randomized controlled trial. Data on sociodemographic, anthropometric, body composition and biochemistry were collected at baseline and after 3 months of intervention. The multiple logistic regression analysis was conducted to determine the association between VFA loss (no loss, < 5% loss, and ≥ 5% loss) and improvement in cardiometabolic markers. For each cardiometabolic marker, an improvement surpassing the minimum threshold of the third tertile was classified as a good improvement.</p><p><strong>Results: </strong>Compared to those with no VFA loss, participants with VFA loss of ≥ 5% were significantly associated with a higher improvement in waist circumference (OR 2.97, 95% CI 1.16-7.64), high-density lipoprotein cholesterol (HDL-C) (OR 4.19, 95% CI 1.58-11.14), triglycerides (OR 3.01, 95% CI 1.14-7.92), and glycated hemoglobin (HbA1C) (OR 2.95, 95% CI 1.12-7.79). Other than that, those with < 5% VFA loss were 3.6 times more likely to have a higher improvement in HDL-C compared to those with no VFA loss (OR 4.08, 95% CI 1.36-12.22).</p><p><strong>Conclusion: </strong>This study found that the magnitude of VFA loss is an independent determinant of improvements in cardiometabolic markers and should be set as a clear target when designing obesity prevention programs.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1576599"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in reproductive biology and disorders: a comprehensive review.","authors":"Jinguang Wang, Dan Wang, Yuemin Zhang, Pingping Sun, Lankai Yi, Ailing Han, Wenjie Zhao, Yuhua Zhang, Huagang Ma","doi":"10.3389/fendo.2025.1550068","DOIUrl":"10.3389/fendo.2025.1550068","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) facilitate intercellular communication and the conveyance of bioactive substances, including proteins, lipids, and nucleic acids. They play a significant role in various reproductive biological processes, including gametogenesis, fertilization, early embryo development, and implantation. Dysfunctional EV activity is associated with various reproductive diseases, such as polycystic ovary syndrome (PCOS), endometriosis, male infertility, and recurrent pregnancy loss (RPL). This review systematically examines and categorizes current knowledge on EV functions in reproductive biology and disorders, and their potential as diagnostic and therapeutic tools. A systematic literature search from 2000 to 2024 identified studies showing EVs' influence on gamete maturation, fertilization, embryonic development, and implantation. They also play a role in reproductive disorders by affecting insulin resistance, androgen production, inflammation, angiogenesis, sperm quality, and maternal-fetal immune tolerance. The review concludes that EVs are integral to reproductive health, with further research needed to understand their mechanisms and clinical potential.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1550068"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Horner syndrome as a complication of ultrasound-guided ablation therapy for thyroid nodules: a scoping review.","authors":"Tianhao Xie, Yan Fu, Xiaoshi Jin, Xiangxiang Ren, Jing Zhang, Qian Sun","doi":"10.3389/fendo.2025.1607214","DOIUrl":"10.3389/fendo.2025.1607214","url":null,"abstract":"<p><strong>Objective: </strong>To synthesize evidence on Horner syndrome (HS) as a complication of ultrasound-guided ablation therapy for thyroid nodules, including its incidence, mechanisms, risk factors, and prevention strategies, to enhance ablation safety and guide future research.</p><p><strong>Data sources: </strong>Web of Science, PubMed, Cochrane Library, and Embase.</p><p><strong>Review methods: </strong>Based on the framework of the PRISMA-ScR, a search was conducted in databases up to December 31, 2024.</p><p><strong>Results: </strong>Twelve articles were included, covering Microwave Ablation (MWA), Radiofrequency Ablation (RFA), High-Intensity Focused Ultrasound (HIFU), and Percutaneous Ethanol Injection (PEI). HS incidence rates varied: MWA 0.4%-4.2%, RFA 0.1%-1.5%, HIFU 1.5%-6.7%, with PEI incidence unspecified due to insufficient data. HS mechanisms included thermal injury to the cervical sympathetic chain, nerve damage from ethanol extravasation, and mechanical compression. Risk factors included ablation zones adjacent to the middle cervical ganglion (MCG), improper ablation parameter settings (such as excessively high power or prolonged duration), and nodule locations near the inferior thyroid artery. Prevention strategies emphasized precise preoperative ultrasound localization of the CSC and MCG, optimization of the isolation belt technique, timely adjustment of ablation parameters, real-time monitoring of symptoms, and avoiding the ablation probe tip from extending beyond the nodule edge.</p><p><strong>Conclusion: </strong>HS is a rare but serious complication with varying incidence rates by technique. Risk can be reduced through precise assessment, meticulous techniques, and technological innovations. Future prospective studies are needed to clarify incidence rates, long-term prognosis, and refine clinical practice guidelines.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1607214"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of foot self-care practice among diabetic patients in Africa: systematic review and meta-analysis.","authors":"Yibeltal Assefa Atalay, Bersufekad Wubie Alemie, Kelemu Abebe Gelaw","doi":"10.3389/fendo.2025.1527402","DOIUrl":"10.3389/fendo.2025.1527402","url":null,"abstract":"<p><strong>Introduction: </strong>Nowadays, diabetes mellitus is a major global health issue with serious social, economic, and developmental impacts. One of its most severe complications is foot problems. Research shows that poor self-care practices in managing diabetic feet are a key factor in ulcer development.</p><p><strong>Objective: </strong>This study aimed to determine the pooled prevalence of foot self-care practice and associated factors among diabetic patients in Africa.</p><p><strong>Methods: </strong>We found articles using electronic databases, including PubMed, Cochrane Library, Google Scholar, Web of Science, African Journals Online, and Science Direct. Accordingly, we identified 143 published articles. A total of 31 eligible studies were included in the systematic review. Data extraction used a standardized checklist, and analysis was conducted with STATA 14 statistical software. Various methods were used to assess the presence of publication bias, including funnel plots and the Begg and Egger regression test. A significance level of P ≤0.05 was used to indicate potential publication bias. Heterogeneity between included studies was assessed using the I2 statistics. The random effect model was used to estimate the pooled estimates.</p><p><strong>Results: </strong>The pooled prevalence of foot self-care practices among diabetic patients in Africa was 46.93% (95%CI (39.44-54.41)). Diabetic foot self-care practices were significantly associated with rural residence (AOR: 2.50, 95% CI (1.65-3.80)), educational level (AOR: 3.00, 95%CI (2.07-4.34)), and knowledge level of diabetes patients (AOR: 3.41, 95%CI (2.22-5.23)).</p><p><strong>Conclusions: </strong>In conclusion, more than half of diabetic patients had poor diabetes foot self-care practices. Diabetic foot self-care practice was associated with a level of education, rural residence, and the knowledge level of diabetic foot care. Therefore, intervention programs ought to prioritize enhancing the knowledge base of individuals with diabetes to promote better self-care practices for their feet.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1527402"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride-glucose related indices and at-risk NASH in U.S. adults with NAFLD: results from NHANES 2017-2020.","authors":"Hanchen Ma, Wenjie Zhang, Zheng Zhao, Shuaichen Jin, Linchuan Li, Ruizhao Zong, Wuyang Li, Ziwei Zhang, Shichang Cui, Yunmiao Pan, Jiankang Zhu, Guangyong Zhang","doi":"10.3389/fendo.2025.1604991","DOIUrl":"10.3389/fendo.2025.1604991","url":null,"abstract":"<p><strong>Introduction: </strong>Nonalcoholic fatty liver disease (NAFLD), intricately linked to insulin resistance (IR), obesity, and metabolic syndrome (MetS), affects nearly one-third of the global population. The triglyceride-glucose (TyG) index and its derivative metrics, which integrate anthropometric measures, have emerged as cost-effective tools for assessing IR severity and their associations with NAFLD severity. However, evidence on their association with at-risk nonalcoholic steatohepatitis (NASH), a progressive phenotype characterized by hepatic fibrosis and inflammation, remains limited. This study aimed to evaluate the relationship between TyG related indices and at-risk NASH in a nationally representative NAFLD cohort.</p><p><strong>Methods: </strong>Using data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES), adults with NAFLD diagnosed via vibration-controlled transient elastography (VCTE) were analyzed. At-risk NASH was defined using the FibroScan-AST (FAST) score. Five TyG related indices (TyG, TyG-WC, TyG-WHR, TyG-WtHR, TyG-BMI) were calculated and analyzed through weighted logistic regression, stratified analyses, restricted cubic spline (RCS), and receiver operating characteristic (ROC) analyses. Adjustments included demographics and clinical confounders.</p><p><strong>Results: </strong>Among participants, 10% exhibited at-risk NASH. Composite indices (TyG-WC, TyG-WHR, TyG-WtHR, TyG-BMI) each showed higher ORs than TyG alone in Model 3. TyG-WtHR exhibited the strongest association both as a continuous variable and across tertiles in Model 3, demonstrating a near-linear dose-response relationship. RCS analysis revealed no significant nonlinear relationships in composite indices, whereas the TyG index demonstrated a significant nonlinear association. Stratified analyses revealed elevated risks in males, middle-aged adults, and Non-Hispanic Black individuals. ROC analysis showed the discriminative performance of TyG-WC, while TyG-WtHR balanced sensitivity and specificity.</p><p><strong>Conclusion: </strong>This study demonstrated significant associations between TyG-related indices and at-risk NASH in NAFLD patients. These non-invasive, cost-effective biomarkers may facilitate for early risk stratification, guiding precision interventions, and optimizing clinical trial design to improve patient outcomes.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1604991"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The serum uric acid to apolipoprotein A1 ratio is independently correlated with metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus: findings from a single national metabolic management center cohort.","authors":"Xiu Li Guo, Mei Tu, Xiu Ping Qiu, Wei Wang","doi":"10.3389/fendo.2025.1619003","DOIUrl":"10.3389/fendo.2025.1619003","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence suggests that the serum uric acid to apolipoprotein A1 ratio (UAR) may be a novel biomarker for metabolic dysfunction-associated steatotic liver disease (MASLD). This study aims to investigate the relationship between UAR and MASLD, and compare the diagnostic ability of UAR with other insulin resistance-related markers for MASLD in individuals with type 2 diabetes mellitus (T2DM).</p><p><strong>Method: </strong>A cohort of 1,019 individuals with T2DM was recruited from the National Metabolic Management Center of our hospital. Unenhanced abdominal CT scans were performed to evaluate liver steatosis for diagnosing MASLD. The association between UAR and the risk of MASLD was analyzed using weighted binomial logistic regression, restricted cubic splines (RCS), and subgroup analysis. Receiver operating characteristic (ROC) curve analysis was conducted to compare the diagnostic performance of UAR with other insulin resistance-related markers, including the serum uric acid to high-density lipoprotein cholesterol ratio (UHR), triglyceride to high-density lipoprotein cholesterol ratio (THR), and triglyceride to apolipoprotein A1 ratio (TAR).</p><p><strong>Results: </strong>Participants in the MASLD group exhibited elevated UAR levels. After full adjustments for potential confounders, UAR remained independently associated with MASLD (<i>OR:</i> 1.65, 95% CI: 1.45-1.89, <i>P</i> < 0.001). Subgroup analyses revealed that this association was consistent across various subgroups, including sex, drinking status, hypertension, lipid-lowering therapy, and body mass index (<i>P</i> < 0.05). RCS analysis demonstrated a linear increase in the risk of MASLD with higher UAR levels (<i>P</i> for nonlinear = 0.319). ROC curve analysis indicated that UAR provided good diagnostic performance for MASLD (AUC:0.777, 95% CI: 0.749- 0.805), comparable to TAR (AUC difference: -0.003, 95% CI: -0.033-0.026, <i>P</i> = 0.818) and superior to UHR (AUC difference: 0.043, 95% CI: 0.019-0.067, <i>P</i> < 0.001) and THR (AUC difference: 0.035, 95% CI: 0.019-0.067, <i>P</i> = 0.047).</p><p><strong>Conclusion: </strong>UAR was independently associated with MASLD and demonstrated significant diagnostic value, indicating that UAR could be a cost-effective biomarker to help identify high-risk individuals for MASLD.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1619003"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous ethanol and calcitriol injection therapy for hyperparathyroidism - a single-centre experience.","authors":"Eugene Kwong Fei Leong, Ray Meng See, Zhimin Lin, Meredeth Choon Siang Chin, Joshua Wei Yang Chew, Kee Yuan Ngiam, James Wai Kit Lee","doi":"10.3389/fendo.2025.1562493","DOIUrl":"10.3389/fendo.2025.1562493","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study is to evaluate the use of percutaneous ethanol and calcitriol injection therapy for hyperparathyroidism (HPT), while taking into account the efficacy, safety and feasibility as an ambulatory procedure alternative to surgical parathyroidectomy.</p><p><strong>Methods: </strong>We included nine patients who underwent percutaneous injection therapy for HPT from January 2018 to December 2021 in our institution. They were followed up from date of first percutaneous injection until death or October 2022 (mean duration of 9.0 months).</p><p><strong>Results: </strong>Four patients underwent percutaneous ethanol injection therapy (PEIT) (mean age 61.0 [31-89] years old), while the remaining five underwent percutaneous calcitriol therapy (PCIT) (mean age 62.6 [35-91] years old). The analyzed parameters are age, BMI, serum turn over markers as iPTH, Ca, alkaline phosphatase and vitamin D. Two out of the four patients undergoing PEIT had a successful outcome, although one needed to continue cinacalcet due to persistent serum calcium levels. Three out of five PCIT patients in our series had successful procedure, although one subsequently developed refractory disease.</p><p><strong>Conclusion: </strong>PEIT and PCIT are feasible and safe therapeutic alternatives to surgical parathyroidectomy in HPT refractory to medical treatment, with postulated benefits of decreased costs and being an outpatient procedure. However, further studies are necessary to evaluate the efficacy and cost-effectiveness with these techniques prior to widespread adoption.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1562493"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index and overactive bladder syndrome: evidence from the NHANES 2005-2018.","authors":"Baitong Chen, Jiongming Wang, Yueting Huang, Nanhui Chen","doi":"10.3389/fendo.2025.1610140","DOIUrl":"10.3389/fendo.2025.1610140","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between the triglyceride-glucose index (TyG) and overactive bladder (OAB) is unclear. The aim of this study was to investigate the possible association between the TyG index and OAB.</p><p><strong>Methods: </strong>National Health and Nutrition Examination Survey (NHANES) data from 2005-2018 were used. The association between TyG index and OAB was assessed using univariate and multivariate logistic regression models. In addition, restricted cubic spline curves were used to examine the dose-response relationship between TyG index and OAB risk. Subgroup analyses and interaction analyses were then performed to assess differences in associations between subgroups.</p><p><strong>Results: </strong>A total of 14,059 participants with 3325 patients with OAB were included. In the fully adjusted model, each unit increase in the TyG index was associated with a 1.18-fold increased risk of OAB (OR = 1.18; 95% CI: 1.11-1.26; p < 0.001) and a 1.32-fold increased risk of OAB for Q4 compared to Q1 at the quartile level (OR = 1.32, 95% CI: 1.17- 1.50, p < 0.001), RCS analysis showed a positive linear association between TyG index and OAB, and subgroup analysis showed that the association between TyG and OAB was more pronounced in individuals younger than 60 years and in women (p for interaction < 0.05).</p><p><strong>Conclusion: </strong>The results of this study suggest that TyG index is positively associated with OAB, and this association was more pronounced in younger age groups and in females.TyG index, as a simple and cost-effective metabolic marker, may provide a potential tool for early screening of OAB, especially in individuals with metabolic abnormalities that have not progressed to significant metabolic diseases.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1610140"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Describing the initial results of a pragmatic, cluster randomized clinical trial to examine the impact of a multifaceted digital intervention for the prevention of type 2 diabetes mellitus in the primary care setting: intervention design, recruitment strategy and participants' baseline characteristics of the PREDIABETEXT trial.","authors":"Sofía Mira-Martínez, Rocío Zamanillo-Campos, Narges Malih, Maria Antonia Fiol-deRoque, Escarlata Angullo-Martínez, Rafael Jimenez, Maria Jesús Serrano-Ripoll, José Iván Oña, Aina M Galmes-Panades, Rocío Gómez-Juanes, Jadwiga Konieczna, Jerónima Miralles, Dora Romaguera, María Clara Vidal-Thomas, Joan Llobera-Canaves, Mauro García-Toro, Elena Gervilla-García, Catalina Vicens, Oana Bulilete, Juan José Montaño, Margalida Gili, Miquel Roca, Antoni Colom, Ignacio Ricci-Cabello","doi":"10.3389/fendo.2025.1604990","DOIUrl":"https://doi.org/10.3389/fendo.2025.1604990","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fendo.2025.1524336.].</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1604990"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}