Frontiers in Endocrinology最新文献

{"title":"Efficacy and safety of thermal ablation for Bethesda III/IV thyroid nodules: a retrospective study.","authors":"Song Li, Ying Wei, Zhen-Long Zhao, Li-Li Peng, Yan Li, Ming-An Yu","doi":"10.3389/fendo.2025.1572535","DOIUrl":"10.3389/fendo.2025.1572535","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the efficacy and safety of thermal ablation (TA) for the treatment of Bethesda III and IV thyroid nodules.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on 154 patients with Bethesda III (n = 82) and IV (n = 72) thyroid nodules treated with microwave or radiofrequency ablation between December 2016 and October 2023. Patients were followed for a median of 19 months. Outcomes assessed included nodule volume reduction rate (VRR), complications, and disease progression.</p><p><strong>Results: </strong>The median VRR at 12 months was 97% (Bethesda III) and 88% (Bethesda IV), increasing to 100% and 96% by 36 months, respectively, with no significant differences between groups. No major complications were encountered, minor complications occurred in 4 patients (4/154, 2.6%), including 3 cases of transient hoarseness and 1 case of neck pain, resolving spontaneously. Disease progression (3/154, 1.9%) occurred in both groups, with new tumor in each group, no other disease progression occurred.</p><p><strong>Conclusion: </strong>Thermal ablation could be a safe, effective, and minimally invasive alternative to surgery for Bethesda III/IV thyroid nodules, achieving substantial volume reduction with minimal complications.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1572535"},"PeriodicalIF":3.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of overnight culture after thawing of D3 cleavage-stage embryos on clinical pregnancy outcomes: focus on embryo development to day 4.","authors":"Liuping Lan, Xiang Li, Bowen Luo, Weiwu Liu, Lingling Zhu, Juguang Zhang, Jian Wen, Keng Feng, Derong Li, Feifei Lei, Guosheng Deng, Yudi Luo, Zengyu Yang","doi":"10.3389/fendo.2025.1530112","DOIUrl":"https://doi.org/10.3389/fendo.2025.1530112","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the impact of day-3 (D3) cleavage-stage embryo thawing with immediate transfer versus thawing and overnight culture before transfer on clinical outcomes. It also examines the relationship between cleavage-stage embryo developmental speed after overnight culture and clinical pregnancy outcomes, as well as factors influencing clinical pregnancy in frozen embryo transfer (FET).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 1,040 patients who underwent D3 cleavage-stage frozen embryo transfer at Yulin City Maternal and Child Health Hospital between July 2022 and December 2023. Patients were divided into two groups based on embryo culture time after thawing: control (same-day transfer, 2-3 hours) and experimental (overnight culture, 18-20 hours). Clinical pregnancy rates, embryo implantation rates, early miscarriage rates, and multiple pregnancy rates were compared between groups. The experimental group was further subdivided based on the number of cleavage blastomeres increased after culture: A1 (≥4 blastomeres), A2 (1-3 blastomeres), and A3 (no increase). A binary logistic regression analysis identified independent factors affecting clinical pregnancy outcomes in FET.</p><p><strong>Results: </strong>No significant differences were found between the control and experimental groups in clinical pregnancy rate (37.2% vs. 40.2%), embryo implantation rate (24.9% vs. 26.4%), early miscarriage rate (13.1% vs. 18.8%), or multiple pregnancy rate (9.2% vs. 10.2%) (<i>P</i> > 0.05). In the experimental group, clinical pregnancy rates for A1, A2, and A3 subgroups were 44.2%, 29.8%, and 25.5%, respectively. Early miscarriage rates were 18.6%, 10.7%, and 38.5%, showing statistically significant differences (<i>P</i> < 0.05). Female age, endometrial thickness, embryo morphology, and the number of cleavage blastomeres were identified as independent factors influencing clinical pregnancy rate.</p><p><strong>Conclusion: </strong>This study indicates that D3 embryos with an increase in the number of blastomeres to more than four or entering the compaction stage after overnight culture have better pregnancy outcomes. Female age and endometrial thickness are important factors influencing clinical pregnancy rates. Optimizing culture conditions and ensuring optimal endometrial thickness may help improve the success rate of frozen-thawed embryo transfer.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1530112"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid-lowering effect of combined therapy with high-intensity statins and CETP inhibitors: a Systematic Review and meta-analysis.","authors":"Liubo Xiang, Huan Wu, Zhihao Zhao, Tingchun Wu, Dawei Lv, Ping Wu, Yuhua Zheng, Qianqian Huang, Tao Xu","doi":"10.3389/fendo.2025.1512670","DOIUrl":"https://doi.org/10.3389/fendo.2025.1512670","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the impact of combining high-intensity statins with CETP inhibitors on lipid levels, as well as to explore their potential clinical significance.</p><p><strong>Methods: </strong>We conducted a comprehensive search of relevant studies in the PubMed, Embase, Cochrane Library, and Web of Science databases. The Cochrane Risk of Bias Tool RoB 2.0 was employed to evaluate the quality of the included studies. Statistical analyses were carried out using STATA 15 software, with primary outcomes being high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).</p><p><strong>Results: </strong>Out of 2,552 records, 7 studies were included in the final analysis. The findings revealed that the combination of high-intensity statins with CETP inhibitors significantly raised HDL-C levels (SMD 2.47 [1.77, 3.18], p < 0.001) and lowered LDL-C levels (SMD -1.75 [-2.19, -1.31], p < 0.001).</p><p><strong>Conclusion: </strong>Compared to statin monotherapy, the combination of high-intensity statins and CETP inhibitors resulted in a more pronounced increase in HDL-C and ApoAI, while reducing LDL-C, triglycerides (TG), and ApoB levels, without increasing the incidence of adverse events.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1512670"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma.","authors":"Run Ting Chin, Jolene Jiayu Kiew, Khek Yu Ho, Doddabele S Deepak","doi":"10.3389/fendo.2025.1524288","DOIUrl":"https://doi.org/10.3389/fendo.2025.1524288","url":null,"abstract":"<p><p>Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the use of diazoxide can be complicated by diabetic ketoacidosis (DKA). This case report describes a frail elderly patient with high surgical risk diagnosed with pancreatic head insulinoma whose initial treatment with diazoxide was complicated by a hyperglycemic crisis. Her insulinoma was eventually managed with endoscopic ultrasound-guided-radiofrequency ablation (EUS-RFA) with complete resolution of hypoglycemic episodes. This case highlights the importance of monitoring for side effects of diazoxide, especially in the elderly, and the role of EUS-RFA as an emerging non-surgical treatment modality for insulinoma.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1524288"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood biochemical landscape and new insights into clinical decision-making for polycystic ovary syndrome in Chinese women: a prospective cohort study.","authors":"Yutong Li, Xiufeng Lin, Ke Zou, Jing Du, Qingni Li, Linkun Zhong, Shan Jiang","doi":"10.3389/fendo.2025.1534733","DOIUrl":"10.3389/fendo.2025.1534733","url":null,"abstract":"<p><strong>Introduction: </strong>The Polycystic ovary syndrome (PCOS), a prevalent endocrine disorder affecting women's reproductive and metabolic health, faces diagnostic challenges due to heterogeneous clinical presentations and the absence of reliable biomarkers. This study investigates the role of Glucosaminyl (N-acetyl) transferase 2 (GCNT2) in modulating sex hormone-binding globulin (SHBG) and its potential as a therapeutic target in PCOS pathophysiology.</p><p><strong>Methods: </strong>A prospective cohort of 103 PCOS patients treated with oral contraceptives (2021-2024) was established. Bidirectional Mendelian randomization (MR) was employed to assess genetic associations and causal relationships between PCOS and SHBG. Molecular docking studies evaluated cryptotanshinone's binding affinity to key proteins (COL1A1, COL4A2, COL6A2) in the PI3K/Akt pathway. GCNT2's regulatory effects on collagen synthesis and extracellular matrix pathways. Pharmacokinetic profiling validated therapeutic viability.</p><p><strong>Results: </strong>Bidirectional MR revealed significant genetic associations (<i>P</i> < 0.001) and causal links between PCOS and SHBG, implicating GCNT2 as a key modulator. Cryptotanshinone exhibited strong binding affinity to PI3K/Akt signaling pathway proteins and favorable pharmacokinetic properties. Enrichment analyses highlighted GCNT2's role in collagen biosynthesis (<i>FDR</i> < 0.05) and extracellular matrix regulation.</p><p><strong>Discussion: </strong>This study identifies GCNT2 as a critical mediator of PCOS pathophysiology through SHBG modulation and collagen remodeling. Cryptotanshinone emerges as a promising therapeutic candidate, targeting PI3K/Akt signaling pathway with high specificity. These findings advance the understanding of PCOS mechanisms and provide a foundation for biomarker-driven diagnostics and precision therapeutics. Further validation in clinical trials is warranted to translate these insights into practice.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1534733"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of pemafibrate and omega-3 fatty acid ethyl on fatty liver index in patients with dyslipidemia treated with statin: a sub-analysis from the PROUD48 study.","authors":"Yasutaka Takeda, Masato Furuhashi, Ichiro Sakuma, Shinya Hiramitsu, Mizuho Okada, Shinichiro Ueda, Naoki Kumashiro, Masaru Sakurai","doi":"10.3389/fendo.2025.1549687","DOIUrl":"https://doi.org/10.3389/fendo.2025.1549687","url":null,"abstract":"<p><strong>Background: </strong>Fatty liver index (FLI) calculated by using body mass index, waist circumference and levels of triglycerides and γ-glutamyl transpeptidase is a noninvasive biomarker for diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD), which is one of the high-risk conditions of atherosclerotic cardiovascular diseases. To compare the effects of pemafibrate and omega-3 fatty acid ethyl on FLI, we conducted a sub-analysis study of the Pemafibrate Reduction of triglyceride-rich lipoproteins compared with Omega-3 fatty acid ethyl for Unmet needs in Dyslipidemic patients on target to apoB-48 (PROUD48) study.</p><p><strong>Methods: </strong>57 participants in the pemafibrate 0.4 mg per day treatment group (PEMA, men/women: 37/20, mean 64 years) and 60 participants in the omega-3 fatty acid ethyl 4 g per day treatment group (OMEGA-3, men/women: 35/25, mean 63 years) in the PROUD48 study were included in the present study. Changes in FLI and prevalence of MASLD from baseline to week 16 in PEMA and OMEGA-3 were investigated.</p><p><strong>Results: </strong>Median FLI was significantly decreased by both PEMA (69.7 to 47.6, <i>P</i> < 0.001) and OMEGA-3 (64.8 to 59.5, <i>P</i> < 0.001). There was a significant difference in change in FLI between PEMA and OMEGA-3 (-18.3 ± 14.1 vs. -5.5 ± 9.4, <i>P</i> < 0.001). The proportions of MASLD estimated by FLI (baseline/week 16) in PEMA and OMEGA-3 were 93.0/68.4% (<i>P</i> = 0.002) and 90.0/85.0% (<i>P</i> = 0.582), respectively.</p><p><strong>Conclusions: </strong>Pemafibrate is superior to omega-3 fatty acid ethyl in lowering effects of FLI and MASLD in patients with dyslipidemia receiving statin treatment, suggesting that pemafibrate is a beneficial agent for hypertriglyceridemia and reduction of the risk for MASLD.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1549687"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine characterization into schizophrenia: norepinephrine and melatonin as promising biomarkers.","authors":"Junwei Shen, Xin Li, Yinghua Zhong, Jiechun Zhang, Hongyun Qin, Fazhan Chen, Xudong Zhao","doi":"10.3389/fendo.2025.1551172","DOIUrl":"https://doi.org/10.3389/fendo.2025.1551172","url":null,"abstract":"<p><strong>Background: </strong>Although brain-derived neurotrophic factor (BDNF)has garnered extensive attention as a neuroendocrine marker in schizophrenia (SZ), its clinical utility remains limite due to inconsistent findings.</p><p><strong>Methods: </strong>To address this gap, serum samples were collected from 24 female patients with SZ and 25 healthy controls. The metabolic profiling was performed using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) to capture abroad range of metabolites.</p><p><strong>Results: </strong>Our results revealed that BDNF is not a robust discriminatory biomarker. Marked differences in metabolic profiles were identified between patients with SZ and healthy individuals. The GC-MS analysis revealed significant differences in 79 metabolites; while the LC-MS analysis identified 419 significantly differential metabolites. Functional analysis reveals that these differential metabolites predominantly contribute to metabolic and neuro-related processes. Our findings demonstrate that norepinephrine and melatonin, two additional neuroendocrine compounds, are significantly elevated in patients with SZ compared to healthy controls. Notably, their higher areas under the curve (AUC) values compared to BDNF highlight their potential as more reliable biomarkers for SZ.</p><p><strong>Conclusion: </strong>This study offers valuable insights into the altered metabolic patterns of female patients with SZ and establishes melatonin and norepinephrine as promising neuroendocrine biomarkers, underscoring their diagnostic value and role in the neuroendocrine regulation of mental disorders.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1551172"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of gestational diabetes mellitus diagnosed at different time points in oral glucose tolerance test with adverse pregnancy outcomes: a retrospective cohort study.","authors":"Ruipeng Lin, Yulong Zhang, Yuxin Lin, Lili Yang, Jiayi Chen, Qingxiu Li, Haibo Li, Qian Zhang","doi":"10.3389/fendo.2025.1493520","DOIUrl":"https://doi.org/10.3389/fendo.2025.1493520","url":null,"abstract":"<p><strong>Background: </strong>This study aims to explore the association between gestational diabetes mellitus (GDM) diagnosed at different time points in the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes (APO).</p><p><strong>Methods: </strong>A retrospective cohort study based on the 75g OGTT conducted in Fujian Maternity and Child Health Hospital. GDM was diagnosed if plasma glucose levels exceeded the threshold at any time point (5.1 mmol/L at 0h, 10.0 mmol/L at 1h, and 8.5 mmol/L at 2h). Binary logistic regression and subgroup analysis were used to analyze the association between abnormal plasma glucose in OGTT and APO.</p><p><strong>Results: </strong>The study included 37,598 normal pregnancies and 11,302 APO. Compared to the normal group, pregnant women with GDM and abnormal plasma glucose at different time points had an increased risk of APO. Group 2 (abnormal at 0h, but normal at 1h and 2h), Group 3 (normal at 0h, but abnormal at 1h or 2h), and Group 4 (abnormal at 0h, 1h or 2h) showed an increasing trend in APO risk compared to Group 1 (normal at three time points), with adjusted OR of 1.14, 1.18, and 1.42, respectively (<i>P</i><0.001). The subgroup analysis showed no statistically interaction, and the sensitivity analysis results were stable.</p><p><strong>Conclusion: </strong>Abnormal plasma glucose at different time points is associated with the risk of APO, with the highest risk observed in those with abnormalities at all time points. Future health management for high-risk pregnant women should be strengthened by considering abnormal plasma glucose at different time points.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1493520"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of weight-adjusted-waist index and systemic immune-inflammatory index with sKlotho: evidence from the NHANES 2007-2016.","authors":"Mingming Yang, Qiong Xu, Linjuan Huang, Luqian Zhu","doi":"10.3389/fendo.2025.1544796","DOIUrl":"https://doi.org/10.3389/fendo.2025.1544796","url":null,"abstract":"<p><strong>Background: </strong>Klotho is an anti-aging protein, and obesity and inflammation have been identified as having a relationship with Klotho. This study investigated the correlation between weight-adjusted-waist index(WWI), systemic inflammation index(SII) and soluble Klotho (sKlotho) and explored the potential mediating role of SII.</p><p><strong>Methods: </strong>The association between WWI, SII, and sKlotho was investigated using weighted multivariate linear regression, subgroup analysis, and smoothed curve fitting in this cross-sectional study, which was based on NHANES data. The Bootstrap method was used to test for mediation effects. Covariate selection was validated using the variance inflation factor (VIF).</p><p><strong>Results: </strong>The study involved a total of 9,506 participants. The results showed that WWI (β=-0.03; 95%CI:-0.04,-0.01; <i>p</i><0.0001) was associated with SII (β=-0.00, 95%CI:-0.00,-0.00:<i>p</i><0.001) and Ln-sKlotho.There was a negative correlation between both WWI and SII and sKlotho. Subgroup analysis showed that gender, age, education, marital status, family income, HEI, PA, hypertension, diabetes, CKD, alcohol use, smoking, and SII did not affect the negative correlation between WWI and sKlotho (FDR-corrected <i>p</i>>0.1). The mediation analysis showed that SII played a significant mediating effect in the role of WWI on sKlotho, with SII mediating 6.78% of the relationship between WWI and sKlotho.</p><p><strong>Conclusion: </strong>There is a negative correlation between WWI and sKlotho, and SII may be an important mediator between WWI and sKlotho. Reducing inflammatory conditions in obese populations may increase sKlotho levels, which in turn may delay organismal aging in middle-aged and elderly people.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1544796"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pan-immune-inflammation value and its association with all-cause and cause-specific mortality in the general population: a nationwide cohort study.","authors":"Ye Zhang, Yong Yue, Zhengyu Sun, Pengcheng Li, Xiaoyi Wang, Gang Cheng, Hailin Huang, Zongping Li","doi":"10.3389/fendo.2025.1534018","DOIUrl":"https://doi.org/10.3389/fendo.2025.1534018","url":null,"abstract":"<p><strong>Introduction: </strong>The Pan-Immune-Inflammation Value (PIV) is a novel biomarker derived from counts of neutrophils, platelets, monocytes, and lymphocytes, providing a comprehensive measure of systemic immune and inflammatory status. While it has shown prognostic value in specific disease settings, its association with mortality in the general population remains unclear. This study aims to evaluate the predictive value of PIV for all-cause and cause-specific mortality, including cardiovascular, cancer, and diabetes-related deaths, within a general adult population.</p><p><strong>Methods: </strong>Data were obtained from the NHANES cohort, with 48,662 participants aged 20 and older. Participants were followed for an average of 117.44 months, with PIV quartiles calculated at baseline. Cox proportional hazard models were used to assess mortality risk across PIV quartiles, while restricted cubic spline models examined nonlinear dose-response relationships. Subgroup and sensitivity analyses further explored the robustness of PIV's associations.</p><p><strong>Results: </strong>Higher PIV levels were significantly associated with increased risks of all-cause, cardiovascular, cancer, and diabetes mortality. Nonlinear relationships were observed between PIV and all-cause, cardiovascular, and cancer mortality, with a risk threshold at PIV values above 254.07. Subgroup analyses supported these findings, and sensitivity analyses confirmed the consistency of PIV's prognostic value.</p><p><strong>Conclusion: </strong>Elevated PIV serves as an independent risk factor for multiple mortality outcomes in the general population. This study underscores the potential of PIV as a predictive biomarker for mortality risk, with implications for its use in clinical and epidemiological settings. Further studies are needed to confirm PIV's clinical utility across diverse populations and conditions.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1534018"},"PeriodicalIF":3.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}