Frontiers in Endocrinology最新文献

{"title":"Retraction: Erratum: High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy.","authors":"","doi":"10.3389/fendo.2025.1589509","DOIUrl":"https://doi.org/10.3389/fendo.2025.1589509","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3389/fendo.2023.1200774.].</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1589509"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of neutrophil to lymphocyte ratio with all-cause and cardiovascular mortality among individuals with kidney stone disease: result from NHANES, 2007-2018.","authors":"Qihui Chu, Bin Wu, Zhaofu Zhang","doi":"10.3389/fendo.2025.1537403","DOIUrl":"10.3389/fendo.2025.1537403","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study is to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and all-cause as well as cause-specific mortality among patients with kidney stones, and to evaluate the capability of NLR as a predictor of mortality.</p><p><strong>Methods: </strong>This study included 2,995 patients with kidney stones from the NHANES database during the period from 2007 to 2018, and subsequently linked this data with the National Death Index. The relationship between NLR and mortality was analyzed using the Cox proportional hazards model and Kaplan-Meier survival curves. Additionally, restricted cubic spline (RCS) curves were employed to explore the dose-response relationship between NLR and mortality, while time-dependent ROC curves were utilized to assess the predictive capability of NLR for mortality. Finally, the mediating effect of estimated glomerular filtration rate (eGFR) on the relationship between NLR and mortality was also analyzed.</p><p><strong>Results: </strong>This study ultimately included 2,995 patients with kidney stones, with a median follow-up period of 74 months. A total of 395 deaths were recorded, of which 87 were attributed to cardiovascular diseases. An NLR cut-off of 3.62 was identified as significantly associated with survival outcomes using the 'maxstat' package and the principle of maximum rank statistics. The restricted cubic spline plot indicates a non-linear relationship between NLR and both all-cause mortality and cardiovascular mortality. After adjusting for relevant covariates, the Cox regression analysis demonstrated that, in comparison to the lower NLR group, the higher NLR group exhibited a 1.05-fold (HR 2.05, 95% CI 1.51-2.78, <i>P</i> < 0.001) increased risk of all-cause mortality and a 1.99-fold (HR 2.99, 95% CI 1.89-4.72, <i>P</i> < 0.001) increased risk of cardiovascular mortality. Furthermore, eGFR exhibited a significant mediating effect on the relationship between NLR and mortality.</p><p><strong>Conclusion: </strong>This study found that patients with kidney stones exhibiting a high NLR have a significantly increased risk of mortality in the U.S. population. Therefore, monitoring NLR may be important for the prognosis of patients with kidney stones.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1537403"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inverse relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and testosterone in adult males in the United States: a cross-sectional study based on the NHANES database.","authors":"Yangyang Mei, Yiming Chen, Xiaogang Wang, Renfang Xu, Rui Xu, Xingliang Feng","doi":"10.3389/fendo.2025.1478124","DOIUrl":"10.3389/fendo.2025.1478124","url":null,"abstract":"<p><strong>Background: </strong>Testosterone is a crucial hormone for male health, influencing metabolism, cardiovascular function, bone density, and cognitive abilities. Elevated non-HDL cholesterol to HDL cholesterol ratio (NHHR) has been implicated in lipid metabolism disorders, which may adversely affect testosterone levels. This study investigates the association between NHHR and testosterone levels in adult males, utilizing data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 2,859 adult males from the NHANES cycles 2011-2016. Total testosterone levels were measured using isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS). NHHR was calculated and analyzed as both a continuous variable and in quartiles. Multivariable linear and logistic regression models, adjusted for demographic, biochemical, lifestyle factors, and medical comorbidities, were used to assess the relationship between NHHR and total testosterone levels and the risk of testosterone deficiency (TD).</p><p><strong>Results: </strong>Higher NHHR was significantly associated with lower total testosterone levels and increased risk of TD. In fully adjusted models, each unit increase in NHHR was associated with a decrease in total testosterone levels (β = -16.31, 95% CI: -26.58 to -6.04, P = 0.003) and an increased risk of TD (OR = 1.24, 95% CI: 1.07 to 1.44, P = 0.01). When NHHR was analyzed in quartiles, participants in the highest quartile (Q4) had significantly lower testosterone levels (β = -54.98, 95% CI: -86.21 to -23.74, P = 0.001) and a higher risk of TD (OR = 2.04, 95% CI: 1.20 to 3.49, P = 0.01) compared to those in the lowest quartile (Q1). Subgroup analyses confirmed these findings across different age groups, BMI categories, smoking status, and presence of comorbidities. Smooth curve fitting demonstrated a linear relationship among them.</p><p><strong>Conclusion: </strong>Our study is the first to identify a significant association between elevated NHHR and both reduced total testosterone levels and increased risk of TD in a large, representative sample of adult American males. These findings suggest that NHHR could serve as a valuable marker for early identification of individuals at risk for testosterone decline and TD, enabling timely and targeted clinical interventions.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1478124"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the association between visceral adiposity index and diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus in China.","authors":"Xin Zhao, Jianbin Sun, Sixu Xin, Xiaomei Zhang","doi":"10.3389/fendo.2025.1549954","DOIUrl":"10.3389/fendo.2025.1549954","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the correlation between visceral adiposity index (VAI) and diabetes kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM), so as to provide a clinical basis for the prevention and treatment of DKD.</p><p><strong>Methods: </strong>This study retrospectively analyzed 1817 patients with T2DM hospitalized in the department of Endocrinology, Peking University International Hospital from January 2017 to August 2021, including 1053 males and 764 females. According the level of VAI, subjects were divided into three groups.</p><p><strong>Results: </strong>(1) The results showed that with the increase of VAI level, the proportion of DKD gradually increased, and there was a statistical difference (p < 0.05). With the increase of VAI levels, there is an increasing trend in males, age, WC, BMI, WHtR, WHR, VAI, LAP, ABSI, C-Index, CUN-BAE, SBP, DBP, HbA1c, FBG, PBG, UACR, TG, while HDL-C levels show a decreasing trend (p all <0.05). (2)Logistic regression showed that after adjusting age, sex, diabetic duration, smoking, drinking, BP, blood glucose and blood lipids, high level of VAI was an independent risk factor for DKD (HR=1.38, 95% CI 1.18, 1.63). (3)The model to predict the risk of DKD using anthropometric indicators, showed that the AUC of the models ranked VAI>ABSI>C-index>WHR>AVI=BRI>BMI>CUN-BAE>LAP>WHtR.(4)The predictive ability for DKD of Model 1 with VAI was higher than that of Model 2 with BMI.</p><p><strong>Conclusion: </strong>The increase of VAI is an independent predictor of DKD occurrence in patients with T2DM, which provides a certain clinical basis for preventing the development of DKD in patients with T2DM.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1549954"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel target genes in exaggerated cardiac remodeling following myocardial infarction in diabetes.","authors":"Yanru Duan, Shihan Zhang, Yihua Xia, Huili Li, Demin Liu, Yunhui Du","doi":"10.3389/fendo.2025.1536639","DOIUrl":"10.3389/fendo.2025.1536639","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus is a major risk factor for myocardial infarction (MI), yet its molecular mechanisms exacerbating post-MI cardiac remodeling remain unclear.</p><p><strong>Methods: </strong>Type 2 diabetes mellitus mouse model was developed through a high-sugar and high-fat diet (HFD), followed by MI surgery. Four weeks post-surgery, cardiac function was evaluated via echocardiography, and cardiac pathology was examined using Masson's trichrome and wheat germ agglutinin staining. High-throughput sequencing identified differentially expressed mRNAs and long non-coding RNAs (LncRNAs) in diabetic mice with MI. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, along with LncRNA-target-gene analysis, were performed. Validation in human samples of diabetic patients with STEMI confirmed the influence of HFD on the expression of specific genes.</p><p><strong>Results: </strong>The results demonstrate that diabetes significantly impairs cardiac function, exacerbates cardiac fibrosis and hypertrophy. In addition, our extensive examination of human samples has conclusively demonstrated that diabetes significantly modulates the expression of genes (Rapgef5 and Ing1) within the cardiac tissue of individuals afflicted with STEMI, underscoring the intricate interplay between these conditions. In addition, we have found that Rapgef5 and Ing1 are involved in diabetes-mediated cardiomyocyte apoptosis and proliferation following myocardial infarction.</p><p><strong>Discussion: </strong>Diabetes aggravates post-MI remodeling via Rapgef5/Ing1-mediated apoptosis and proliferation, these findings highlight novel therapeutic targets for diabetic cardiovascular complications.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1536639"},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimising OHSS in women with PCOS.","authors":"Sebastian Leathersich, Caitlin Roche, Roger Hart","doi":"10.3389/fendo.2025.1507857","DOIUrl":"10.3389/fendo.2025.1507857","url":null,"abstract":"<p><p>Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication of ovarian stimulation during <i>in vitro</i> fertilisation (IVF) treatment and is associated with significant morbidity and a small risk of mortality. Women with polycystic ovary syndrome (PCOS) are at a substantially increased risk of developing OHSS compared to those without. This paper reviews the current evidence for strategies to mitigate the risk of OHSS in this patient population. In order to minimise the risk of OHSS, clinicians should identify patients at high risk prior to commencing treatment and provide adequate pre-treatment counselling regarding the risks and benefits of IVF treatment, as well as alternative treatment options. Strategies that can reduce the risk of OHSS include co-treatment with metformin in gonadotropin releasing hormone (GnRH) agonist cycles, use of GnRH antagonist or PPOS protocols, appropriate gonadotropin dosing, the use of a GnRH agonist trigger for oocyte maturation in antagonist or PPOS protocols, cryopreservation of all embryos with deferred frozen embryo transfer, and treatment with dopamine-agonists after oocyte collection. <i>In vitro</i> maturation (IVM) offers an alternative with no risk of OHSS, however currently has a lower cumulative live birth rate than conventional IVF. These strategies can prevent significant early and late OHSS in women with PCOS and should be used to optimise the safety of IVF for this high-risk population, striving for OHSS-free treatment for all patients undergoing IVF.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1507857"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACSL4 predicts rapid kidney function decline in patients with diabetic kidney disease.","authors":"Rui Shen, Xin Yu, Caifeng Shi, Yi Fang, Chunsun Dai, Yang Zhou","doi":"10.3389/fendo.2025.1499555","DOIUrl":"10.3389/fendo.2025.1499555","url":null,"abstract":"<p><strong>Background: </strong>Ferroptosis of kidney tubular epithelial cells contributes to the pathogenesis of diabetic kidney disease (DKD). An increase in the enzyme long-chain fatty acid CoA ligase 4 (ACSL4) favors ferroptosis. However, the association between ACSL4 in renal tubules and kidney outcomes of patients with DKD is unknown.</p><p><strong>Methods: </strong>To investigate the predictive property of ACSL4 in rapid kidney function decline in patients with DKD, a retrospective cohort of 72 biopsy-proven DKD patients were enrolled and followed up for a median of 23 months. Tubular expression levels of ACSL4 in the renal biopsy specimens from 72 DKD patients and 12 control subjects were measured using immunohistochemistry staining. The associations between the ACSL4 level and clinical characteristics as well as rapid kidney function decline defined as an estimated glomerular filtration rate (eGFR) slope ≤ -5 ml/min/1.73m²/year were analyzed.</p><p><strong>Results: </strong>ACSL4 was mainly expressed in tubular epithelial cells. The tubular ACSL4 expression levels in the DKD patients were significantly higher than those in the control subjects. ACSL4 was positively correlated with proteinuria and negatively correlated with albumin and hemoglobin at the time of the renal biopsy. During the follow-up time period, the median eGFR slope of these DKD patients was -2.30 ml/min/1.73m²/year. ACSL4 was negatively correlated with the eGFR slope. The top tertile of baseline ACSL4 was found to identify the subjects with DKD who were at high risk for rapid kidney function decline and a similar significant relationship was found using ACSL4 levels as a continuous variable.</p><p><strong>Conclusions: </strong>ACSL4 was associated with a rapid progression of DKD and may serve as a novel pathological biomarker.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1499555"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Is choline kinase alpha a drug target for obesity?","authors":"Juan Carlos Lacal, Salam A Ibrahim, Tahl Zimmerman","doi":"10.3389/fendo.2025.1580595","DOIUrl":"https://doi.org/10.3389/fendo.2025.1580595","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fendo.2024.1492753.].</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1580595"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-high density lipoprotein cholesterol/high density lipoprotein cholesterol is L-shaped associated with all-cause mortality and U-shaped with cardiovascular mortality in hypertensive patients.","authors":"Meiqian Chen, Li Zhang, Qian Liu, Qingxin Gu, Shuhui Yu, Guanzhen Lu","doi":"10.3389/fendo.2025.1490229","DOIUrl":"10.3389/fendo.2025.1490229","url":null,"abstract":"<p><strong>Background: </strong>Patients with hypertension may have better survival rates when their lipid metabolism is in balance. The relationship between the novel composite lipid metric, NHHR, and all-cause and cardiovascular mortality in hypertensive patients remains unknown and warrants further investigation.</p><p><strong>Methods: </strong>We analyzed data from 5,561 hypertensive participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. To determine the optimal NHHR cutoff point, we employed a maximum selection statistics approach. Participants were subsequently divided into groups for multivariate weighted Cox regression analysis. The association between NHHR and mortality risk was examined using restricted cubic splines (RCS). To investigate possible variations among different populations, subgroup analysis and interaction tests were carried out. The predictive capability of NHHR for survival outcomes was evaluated using time-dependent receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Over a median follow-up period of 93 months, patients with hypertension exhibited an all-cause mortality rate of 21.78% and a cardiovascular mortality rate of 7.32%. A markedly elevated risk of cardiovascular death was associated with NHHR levels below 1.66 (HR 1.76; 95% CI 1.31-2.38; P < 0.001), as well as an increased risk of all-cause mortality (HR 1.58; 95% CI 1.31-1.91; P < 0.001). The RCS analysis revealed a U-shaped relationship with cardiovascular mortality (P = 0.0083) and an L-shaped correlation with all-cause mortality (P < 0.0001). Areas under the curve (AUC) for cardiovascular mortality were 0.97, 0.76, and 0.87, and for all-cause mortality were 0.76, 0.84, and 0.80 for the 3-year, 5-year, and 10-year survival periods.</p><p><strong>Conclusions: </strong>The findings indicate that lower NHHR is associated with an increased risk of both cardiovascular and all-cause mortality, highlighting the critical need for comprehensive lipid management in the clinical management of hypertension. These results suggest that NHHR could serve as a valuable tool for identifying high-risk individuals for mortality, and should be incorporated into routine risk stratification assessments for hypertensive patients. This could more effectively improve patient prognosis and guide personalized treatment strategies.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1490229"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIMP2 rs2277698 polymorphism associated with adverse IVF outcomes in Han Chinese women.","authors":"Chun-I Lee, Yu-Jen Lee, Tsung-Hsien Lee, Chi-Ying Lee, Hui-Mei Tsao, En-Hui Cheng, Chun-Chia Huang, Shun-Fa Yang, Maw-Sheng Lee","doi":"10.3389/fendo.2025.1542534","DOIUrl":"10.3389/fendo.2025.1542534","url":null,"abstract":"<p><strong>Background: </strong>Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are critical regulators of extracellular matrix (ECM) proteolysis and play a pivotal role in trophoblast invasion during embryo implantation. This study aimed to investigate the effects of single-nucleotide polymorphisms (SNPs) in MMP and TIMP genes on clinical outcomes in women undergoing <i>in vitro</i> fertilization (IVF).</p><p><strong>Methods: </strong>This retroprospective study included 1014 women undergoing their first fresh IVF cycle without donor eggs at Lee Women's Hospital between January 2014 and December 2015. Peripheral blood samples were collected from all participants for DNA extraction and SNP genotyping using real-time polymerase chain reaction. The study focused on three SNPs: TIMP1 (rs4898 C/T), TIMP2 (rs2277698 C/T), and MMP2 (rs243865 C/T). Associations between these SNPs and IVF outcomes, including clinical pregnancy, embryo implantation, abortion, and live birth rates, were analyzed.</p><p><strong>Results: </strong>Among 560 patients analyzed, no significant differences were observed in baseline characteristics between the live birth and non-live birth groups. However, the minor alleles (CT+TT) of MMP2 (rs243865) and TIMP2 (rs2277698) were significantly more frequent in the non-live birth group (MMP2: 24.4% vs. 17.7%, p = 0.044; TIMP2: 48.1% vs. 34.4%, <i>p</i> = 0.001). In contrast, no significant differences in the genotype distribution of TIMP1 (rs4898) were noted between the groups. Logistic regression analysis identified the minor T allele of TIMP2 as a significant predictor of non-live birth (adjusted odds ratio: 1.725; 95% CI: 1.217-2.445; <i>p</i> = 0.002). Combined genotypes of MMP2/TIMP2, such as CC/CT+TT and CT+TT/CT+TT, were associated with an increased risk of non-live birth, even after adjusting for covariates.</p><p><strong>Conclusions: </strong>The study demonstrates that the minor T allele of TIMP2 (rs2277698 C/T) is associated with poor IVF outcomes, particularly non-live birth. This finding highlights the potential role of genetic variations in TIMP2 in influencing clinical outcomes of IVF. Further research is warranted to elucidate the underlying mechanisms in larger and more diverse populations.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1542534"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}