Frontiers in Endocrinology最新文献

{"title":"Associated factors and principal pathophysiological mechanisms of type 2 diabetes mellitus.","authors":"Luyao Wang, Lianxin Li, Jiaxin Liu, Changting Sheng, Maoyi Yang, Zhipeng Hu, Rensong Yue","doi":"10.3389/fendo.2025.1499565","DOIUrl":"10.3389/fendo.2025.1499565","url":null,"abstract":"<p><p>Type 2 diabetes mellitus(T2DM) as a common chronic disease with an increasing prevalence worldwide that poses a great threat to individual health, and is characterized by chronic hyperglycemia resulting from insulin resistance (IR) coupled with β-cell dysfunction. Mitochondrial dysfunction, obesity, gut microbiota, oxidative stress and inflammation have emerged as a significant contributor to the etiology of T2DM, affecting various metabolic processes critical for glucose homeostasis. This short review underscores their role in enhancing T2DM-related molecular mechanisms and explores recent advancements in diabetic management, further highlights the importance of personalized care plans to address the complexities of the T2DM and aims to improve patient quality of life and long-term health outcome.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1499565"},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical diagnosis and treatment of a patient with hypertension, hypokalemia, and bilateral adrenal adenomas.","authors":"Tingting Zhang, Tao Chen, Wenjie Zhang, Lu Tan, Li Li, Yuchun Zhu, Yan Ren","doi":"10.3389/fendo.2025.1558841","DOIUrl":"10.3389/fendo.2025.1558841","url":null,"abstract":"<p><p>Aldosterone-producing adenoma (APA) is one of the main types of primary aldosteronism (PA). APAs are predominantly unilateral, whereas bilateral APAs are rare. Currently, clinical experience in the diagnosis and treatment of bilateral APAs is limited, posing significant challenges. This article reports the case of a PA patient with bilateral adrenal nodules. Adrenal venous sampling (AVS) revealed no dominant lateral secretion, but ⁶⁸Ga-Pentixafor PET/MR imaging, which targets CXCR4, revealed bilateral positive lesions. The patient achieved biochemical and clinical remission after undergoing bilateral partial adrenalectomy, and CYP11B2 immunohistochemical staining confirmed that both nodules were APAs. This case report suggests that ⁶⁸Ga-Pentixafor nuclear imaging, which targets CXCR4, is a noninvasive and reliable method for PA subtyping and may be the optimal method for the definitive diagnosis of bilateral APA. Bilateral partial adrenalectomy may be an effective and safe surgical procedure for the treatment of bilateral APAs. This study provides new insights and considerations for clinicians in the diagnosis and treatment of bilateral APAs.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1558841"},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of acupuncture as an adjuvant therapy for osteoporosis: a systematic review and meta-analysis of randomized controlled trials.","authors":"Zixin Teng, Jingwei Zhu, Kuiwu Li, Tingting Tong, Wei Li, Haoran Chu, Peiyang Sun","doi":"10.3389/fendo.2025.1561344","DOIUrl":"10.3389/fendo.2025.1561344","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the efficacy and safety of acupuncture as an adjuvant therapy for osteoporosis (OP) through a comprehensive synthesis of recent randomized controlled trial (RCT) evidence.</p><p><strong>Methods: </strong>A systematic literature search was conducted across PubMed, Web of Science, CNKI, and Wanfang databases (2014 - 2024) to identify RCTs investigating acupuncture combined with conventional therapy for OP. Study quality was appraised using the Cochrane Risk of Bias tool, and meta-analyses were performed using RevMan 5.4 and Stata 15.0, with subgroup analyses stratified by intervention type, population characteristics, and treatment duration.</p><p><strong>Results: </strong>28 RCTs (n=2,758) were included. Meta-analysis revealed acupuncture significantly enhanced bone mineral density (BMD) versus controls: total (SMD = 0.47, <i>p</i> = 0.03), femoral neck (MD = 0.05, <i>p</i> = 0.01), lumbar spine (SMD = 0.40, <i>p</i> < 0.001), Ward's triangle (MD = 0.07, <i>p</i> = 0.02), and hip (SMD = 0.55, <i>p</i> < 0.001), with particularly marked improvements in the postmenopausal osteoporosis subgroup. Acupuncture demonstrated significant improvements in treatment efficacy, biochemical markers, pain scores, and symptom assessments, while reducing adverse events. Warm needle moxibustion outperformed controls in femoral neck (MD = 0.07, <i>p</i> = 0.002) and hip BMD (SMD = 0.87, <i>p</i> < 0.001), while electroacupuncture significantly elevated serum calcium (MD = 0.18, <i>p</i> = 0.02). Short-term interventions (≤ 3 months) demonstrated optimal efficacy.</p><p><strong>Conclusion: </strong>Acupuncture demonstrates efficacy and safety as an OP adjuvant therapy. Current evidence is limited by regional bias and methodological heterogeneity. Multicenter, large-sample RCTs are needed to standardize protocols and validate long-term therapeutic efficacy.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024499354.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1561344"},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.","authors":"Yaoyao Zhu, Ge Lu, Weixin Li, Chenchen Su, Pengfei Du, Shuyou Wang, Li Yang, Huanfang Xu, Yigong Fang, Xiaojing Song","doi":"10.3389/fendo.2025.1579031","DOIUrl":"10.3389/fendo.2025.1579031","url":null,"abstract":"<p><strong>Background: </strong>Age-related ovarian dysfunction, characterized by declining follicular reserve and hormonal imbalance, poses a significant challenge in reproductive endocrinology, severely compromising fertility and quality of life. Although acupuncture at conception vessel acupoints is an effective therapeutic approach for managing ovarian dysfunction, the biological underpinnings bridging peripheral stimulation to systemic endocrine regulation remain elusive. Emerging evidence has highlighted interstitial fluid (ISF) dynamics as a potential mediator of mechanotransduction. However, it remains to be elucidated whether ISF transport in the linea alba (abdominal trajectory of conception vessel) influences ovarian function, and whether acupuncture at conception vessel acupoints exerts its therapeutic effects through ISF-mediated substance transport along the linea alba.</p><p><strong>Methods: </strong>We used fluorescence imaging to observe ISF migration patterns in the linea alba of rats, where conception vessel acupoints are located. In addition, we investigated the ovarian functional changes post-ISF obstruction and evaluated the therapeutic effects of acupuncture on ovarian dysfunction in aged rats, both in unblocked and ISF-blockade conditions.</p><p><strong>Results: </strong>Fluorescence imaging revealed ISF transport along the linea alba, with tracers migrating linearly, a pattern abolished by surgical blockade. Abnormal ISF transport in the linea alba may affect the homeostasis of reproductive hormone levels. Serum follicle-stimulating and luteinizing hormones increased while E₂ decreased, accompanied by follicular depletion and hypothalamic-pituitary-ovarian axis dysregulation. Acupuncture at CV4 attenuated ovarian aging, elevating developmental follicle counts, reducing granulosa cell apoptosis, and restoring hypothalamic-pituitary-ovarian axis function. Crucially, these therapeutic benefits were nullified under ISF blockade conditions.</p><p><strong>Conclusion: </strong>Our results suggest that ISF transport in the linea alba may serve as an important mechanistic pathway bridging acupuncture stimulation to ovarian regulation. Our study not only provides a mechanistic basis for the clinical efficacy of acupuncture in treating ovarian disorders but also identifies ISF dynamics as a novel therapeutic target in age-related ovarian dysfunction.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1579031"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PDX1 in early pregnancy is associated with decreased risks of gestational diabetes mellitus and adverse pregnancy outcomes.","authors":"Qian Zhang, Qing-Qing Zhang, Shu-Qin Dong, Xia Liu, Jing Wei, Kai Li, Yu Lu","doi":"10.3389/fendo.2025.1486197","DOIUrl":"10.3389/fendo.2025.1486197","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the association of pancreatic duodenal homeobox-1 (PDX1) in early pregnancy with the risks of gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.</p><p><strong>Methods: </strong>A total of 231 pregnant women were recruited at their initial antenatal care visit during 8-12 gestational weeks in this study. The 75g OGTT was performed during 24-28 gestational weeks. Blood samples were collected to measure PDX1 levels. Participants were followed throughout their pregnancy to monitor for the development of GDM and adverse pregnancy outcomes. The odds ratio (OR) was used to assess the risks of GDM and adverse pregnancy outcomes.</p><p><strong>Results: </strong>Pregnant women in the GDM group had higher levels of HOMA-IR and TyG index, and lower PDX1 levels both in early and mid-pregnancy (P<0.05), but had lower HOMA-β levels only in mid-pregnancy (P<0.05). PDX1 in early pregnancy was negatively correlated with FPG, 2h PG, HOMA-IR, and TyG, while positively correlated with HOMA-β in mid-pregnancy (P<0.05). The adjusted analysis showed that elevated PDX1 levels in early pregnancy were associated with reduced risks of GDM (aOR 0.287, 95%CI 0.130-0.636, P=0.002), macrosomia (aOR 0.249, 95%CI 0.076-0.811, P=0.021) and composite adverse pregnancy outcomes (aOR 0.496, 95%CI 0.256-0.960, P=0.037).</p><p><strong>Conclusion: </strong>Elevated PDX1 in early pregnancy was associated with decreased risks of GDM and adverse pregnancy outcomes.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1486197"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis.","authors":"Lei Yuan, Yale Su, Jiangqi Zhao, Minkyoung Cho, Duo Wang, Long Yuan, Mixia Li, Dongdong Zheng, Hulin Piao, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Ki-Tae Ha, Wonyoung Park, Kexiang Liu","doi":"10.3389/fendo.2025.1578944","DOIUrl":"10.3389/fendo.2025.1578944","url":null,"abstract":"<p><strong>Introduction: </strong>Increasing evidence suggests that individuals with obesity are at a higher risk of developing depression, and conversely, depression can contribute to the onset of obesity, creating a detrimental cycle. This study aims to investigate the potential shared biological pathways between obesity and depression by examining genetic correlations, identifying common polymorphisms, and conducting cross-trait genetic analyses.</p><p><strong>Methods: </strong>We assessed the genetic correlation between obesity and depression using linkage disequilibrium score regression and high-density lipoprotein levels. We combined two different sources of obesity data using METAL and employed bidirectional Mendelian randomization to determine the causal relationship between obesity and depression. Additionally, we conducted multivariate trait analysis using the MTAG method to improve statistical robustness and identify novel genetic associations. Furthermore, we performed a thorough investigation of independent risk loci using GCTA-COJO, PLACO, MAGMA, POPS, and SMR, integrating different QTL information and methods to further identify risk genes and proteins.</p><p><strong>Results: </strong>Our analysis revealed genetic correlations and bidirectional positive causal relationships between obesity and depression, highlighting shared risk SNP (rs10789340). We identified RPL31P12, NEGR1, and DCC as common risk genes for obesity and depression. Using the BLISS method, we identified SCG3 and FLRT2 as potential drug targets.</p><p><strong>Limitation: </strong>Most of our data sources are from Europe, which may limit the generalization of our findings to other ethnic populations.</p><p><strong>Conclusion: </strong>This study demonstrates the genetic causal relationship and common risk SNPs, genes, proteins, and pathways between obesity and depression. These findings contribute to a deeper understanding of their pathogenesis and the identification of potential therapeutic targets.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1578944"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with diabetes and prediabetes among adults with hypertension: a cross-sectional study.","authors":"Qing Meng, Shengqiang Fan, Li Zhang, Bin Shen, Chaoping Zou, Dezhou Sun, Xianghui Liu, Jian Zhang, Shugang Xu","doi":"10.3389/fendo.2025.1523016","DOIUrl":"10.3389/fendo.2025.1523016","url":null,"abstract":"<p><strong>Background: </strong>The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is an emerging composite lipid marker. Prediabetes, characterized by an asymptomatic state with moderate hyperglycemia, is more prevalent than diabetes. This study aimed to elucidate the potential correlation between NHHR and the risk of diabetes and prediabetes among adults with hypertension.</p><p><strong>Methods: </strong>In this cross-sectional survey, we screened National Health and Nutrition Examination Survey (NHANES)-collected data during 2009-2018, identifying a qualifying population of 10,250 individuals. Weighted multivariate logistic regression and curve fitting evaluated the correlation between the NHHR and the incidence of diabetes and prediabetes. To test differences between subgroups, stratified analyses were performed. Additionally, prediction accuracy of the NHHR was assessed using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>We included 10,250 patients with hypertension (mean age, 56.31 ± 16.06 years) including 2,198 with diabetes and 4,138 with prediabetes-a combined prevalence of 61.81%. The fully adjusted model indicated each unit increase in NHHR was associated with a 21% higher risk of diabetes/prediabetes (OR 1.21; 95% CI, 1.15-1.25). Adjustment using multivariable classification models revealed that compared to the lowest NHHR quartile, the odds increased by 41% (OR 1.37; 95% CI, 1.27-1.59, p<0.001) in Q3 and (OR 1.82; 95% CI, 1.62-1.98, p<0.001) in Q4. In patients with hypertension, the NHHR was positively correlated with the prevalence of diabetes and prediabetes, with a nonlinear trend in the fitted curve (nonlinearity, P=0.007). The threshold effect analysis showed that the inflection point for NHHR and the risk of diabetes and prediabetes was 7.09. In particular, when NHHR was below 7.09, a positive correlation was found between NHHR and the risk of diabetes and prediabetes in this population (OR 1.34; 95% CI, 1.28-1.39). Subgroup analyses showed consistent associations across most groups, with a significant interaction in sex.</p><p><strong>Conclusions: </strong>NHHR is positively and non-linearly correlated with diabetes/prediabetes in patients with hypertension, particularly among women. It may serve as a valuable tool for early risk assessment and management.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1523016"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiometabolic index and bone mineral density among adolescents in the United States.","authors":"Haobiao Liu, Rongqi Xiang, Chenyue Liu, Zhuohang Chen, Yuhang Shi, Yiting Liu, Yan Liu","doi":"10.3389/fendo.2025.1535509","DOIUrl":"10.3389/fendo.2025.1535509","url":null,"abstract":"<p><strong>Objectives: </strong>The cardiometabolic index (CMI) serves as a comprehensive metric for evaluating cardiometabolic health, and is correlated with several health outcomes. However, research examining the relationship between CMI and bone mineral density (BMD), particularly in adolescent populations, remains limited and warrants further investigation.</p><p><strong>Methods: </strong>The weighted multiple linear regression analysis was conducted to elucidate the association between CMI and BMD.</p><p><strong>Results: </strong>Our study ultimately included 1,514 participants. After adjusting for pertinent covariates, we observed that per-unit increases in the CMI corresponded with reductions in BMD by 0.052 g/cm² for femoral neck (<i>β</i>=-0.052, 95% CI: -0.087 to -0.018) and 0.048 g/cm² for lumbar spine (L1-L4) (<i>β</i>=-0.048, 95% CI: -0.085 to -0.011). In quartile analyses, individuals in the highest quartile displayed significantly reduced BMD at the femoral neck (<i>β</i>=-0.036, 95% CI: -0.064 to -0.007) and lumbar spine (L1-L4) (<i>β</i>=-0.041, 95% CI: -0.070 to -0.011) compared to those in the lowest quartile (<i>P</i><0.05). No statistical significance was detected between CMI and BMD at the total femur, trochanter, and intertrochanter sites. Furthermore, stratified analyses indicated no significant interactions involving age, sex, or race in relation to CMI and BMD.</p><p><strong>Conclusions: </strong>In the adolescent population, CMI is inversely related to BMD. These findings highlight a potential link between cardiometabolic health and bone health. Future longitudinal investigations are warranted to determine causal relationships and underlying mechanisms.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1535509"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of triglycerides in predicting new-onset arthritis in the general population over 45 years old: evidence from the China health and retirement longitudinal study.","authors":"Weiwei Ma, Honggu Chen, Jing Deng, Qipeng Yuan, Huanan Li","doi":"10.3389/fendo.2025.1530874","DOIUrl":"10.3389/fendo.2025.1530874","url":null,"abstract":"<p><strong>Background: </strong>Arthritis is a common degenerative joint disease with a high prevalence especially in the elderly population. Due to its strong association with chronic pain and dysfunction, arthritis has become an important challenge in public health. Recent studies have shown that triglyceride (TG) levels, as key metabolic markers, may play an important role in the pathogenesis of arthritis, and its associated inflammatory response may accelerate joint degeneration and inflammatory process.</p><p><strong>Objective: </strong>Based on the above findings, the aim of this study was to investigate the association between baseline TG levels and the incidence of arthritis in adults aged 45 years and older, utilizing data from the China Health and Retirement Longitudinal Study(CHARLS).</p><p><strong>Methods: </strong>This study utilized the CHARLS from 2011 to 2018, which included 7,551 participants aged 45 years and older. The association between TG levels and new-onset arthritis was assessed by logistic regression modeling, adjusting for demographic and health-related variables. The potential role of HDL-C, LDL-C, and BMI in the TG-arthritis association was further assessed by mediation analysis, which decomposed the association into direct and indirect effects.</p><p><strong>Results: </strong>During the study period, 3,363 participants (44.5%) developed arthritis. Higher TG levels were significantly associated with arthritis risk, with an 8% increase in arthritis risk for each interquartile range (IQR) increase in TG (OR=1.08; 95% CI, 1.039-1.137.) Interquartile analyses of TG levels showed a significant dose-response trend (<i>P</i> trend <0.05), suggesting that the risk of arthritis tended to rise progressively with higher TG levels. Mediation analysis further revealed that HDL-C mediated approximately 43.5% of the TG-arthritis association, suggesting an important role of HDL-C in the metabolic pathway of arthritis development.</p><p><strong>Conclusion: </strong>Elevated TG levels were significantly associated with an increased risk of arthritis, and this association was partially mediated by HDL-C. The findings suggest that interventions targeting reduced TG levels and enhanced HDL function may have potential value in arthritis prevention. Future studies should focus on lipid metabolism intervention strategies to reduce arthritis risk and delay disease progression, providing a new scientific basis for arthritis management.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1530874"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index predicts ventricular aneurysm formation in acute ST-segment elevation myocardial infarction.","authors":"Xiaobin Zeng, Yanyu Zhang, Xiaoshuang Xie, Jianjun Lan, Shiyang Li","doi":"10.3389/fendo.2025.1423040","DOIUrl":"10.3389/fendo.2025.1423040","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride-glucose (TyG) index has been confirmed to be a predictor of cardiovascular diseases. The present study aimed to assess the predictive value of TyG index for left ventricular aneurysm (LVA) formation and prognosis in patients with acute ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>This prospective study included 991 patients with acute STEMI who underwent primary PCI. Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were used to assess the predictive value of TyG index for LVA formation. Prognosis analysis was performed with cox proportional hazard regression.</p><p><strong>Results: </strong>The prevalence of LVA was 14.4%. A higher TyG index was associated with a greater incidence of LVA (23.1% vs. 11.8%, P< 0.001). The TyG index was also higher in the LVA group than in the non-LVA group (9.4 ± 0.9 vs. 9.0 ± 0.8, P<0.001). Multivariable logistic regression analysis revealed that the TyG index was independently associated with the risk of LVA [odds ratio (OR)= 2.4, 95% confidence interval (CI)= 1.51-3.82, P< 0.001]. The predictive value of the TyG index remained significant even after cross-validation by dividing the study population into a training set (OR= 2.32, 95% CI= 1.24-4.35, P= 0.009) and validation set (OR= 3.19, 95% CI= 1.42-7.19, P= 0.005). Higher TyG index was correlated with increased risk of cardiac death (HR= 2.17, P= 0.04). The maximal length and width of LVA were significantly increased in patients with TyG index ≥ 9.68 compared with < 9.68 (P< 0.001). The discriminant power of TyG index for LVA was 0.742, which was superior to both triglyceride (C statistic= 0.666) and fasting blood glucose (C statistic= 0.613). The combination of TyG index, left ventricular ejection fraction, gensini score, and left anterior descending artery as the culprit vessel could significantly improve the predictive ability (C statistic= 0.908).</p><p><strong>Conclusions: </strong>A higher TyG index was an independent predictor for LVA formation and increased risk of cardiac death in patients with STEMI who underwent primary PCI.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1423040"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}